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https://www.readbyqxmd.com/read/29333801/efficacy-of-the-regent-suit-based-rehabilitation-on-gait-emg-patterns-in-hemiparetic-subjects-a-pilot-study
#1
Luigi Iuppariello, Giovanni D'Addio, Maria Romano, Paolo Bifulco, Nicola Pappone, Bernardo Lanzillo, Mario Cesarelli
BACKGROUND: The recovery of the functional limb mobility of patients with cerebral damages can take great benefit of the role offered by proprioceptive rehabilitation. Recently have been developed a special Regent Suit (RS) for rehabilitative applications. Actually, there are preliminary studies which describes the effects of RS on gait recovery of stroke patients in acute stage, but none in chronic stage. Moreover, it is known that motor recovery does not always reflect improvements of the muscle activity and coactivity...
January 11, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29332762/the-effect-of-foot-orthoses-on-joint-moment-asymmetry-in-male-children-with-flexible-flat-feet
#2
AmirAli Jafarnezhadgero, Morteza Madadi Shad, Reed Ferber
INTRODUCTION: It has been widely postulated that structural and functional misalignments of the foot, such as flat foot, may cause mechanical deviations of the lower limb during walking. The aim of this study was to investigate the effect of foot orthoses on lower extremity joint moment asymmetry during the stance phase of walking in children with asymptomatic flexible flat feet. METHODS: Fourteen volunteer male children, clinically diagnosed with flexible flat feet, participated in this study...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29330073/the-association-of-clinic-based-mobility-tasks-and-measures-of-community-performance-and-risk
#3
M L Callisaya, J Verghese
INTRODUCTION: Gait speed is recognized as an important predictor of adverse outcomes in older people. However, it is unknown if other more complex mobility tasks are better predictors of such outcomes. OBJECTIVE: To examine a range of clinic-based mobility tests and determine which were most strongly associated with measures of community performance and risk (CP&R). DESIGN: Cross-sectional study SETTING: Central Control Mobility and Aging Study, Westchester County, New York PARTICIPANTS: Aged ≥ 65 years (n=424) METHODS: Clinic-based mobility measures included gait speed measured during normal and dual-task conditions, the Floor Maze Immediate and Delay tasks, and stair ascending and descending...
January 9, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29329344/maintenance-of-muscle-strength-retains-a-normal-metabolic-cost-in-simulated-walking-after-transtibial-limb-loss
#4
Elizabeth Russell Esposito, Ross H Miller
Recent studies on relatively young and fit individuals with limb loss suggest that maintaining muscle strength after limb loss may mitigate the high metabolic cost of walking typically seen in the larger general limb loss population. However, these data are cross-sectional and the muscle strength prior to limb loss is unknown, and it is therefore difficult to draw causal inferences on changes in strength and gait energetics. Here we used musculoskeletal modeling and optimal control simulations to perform a longitudinal study (25 virtual "subjects") of the metabolic cost of walking pre- and post-limb loss (unilateral transtibial)...
2018: PloS One
https://www.readbyqxmd.com/read/29326087/a-multicomponent-exercise-program-improves-physical-function-in-long-term-nursing-home-residents-a-randomized-controlled-trial
#5
Haritz Arrieta, Chloe Rezola, Idoia Zarrazquin, Iñaki Echeverria, Jose Javier Yanguas, Miren Iturburu, Susana Maria Gil, Ana Rodriguez-Larrad, Jon Irazusta
To investigate the impact of a multicomponent exercise program on anthropometry, physical function, and physical activity on older adults living in long-term nursing homes (LTNH), we conducted a randomized controlled trial involving 112 participants aged 84.9 ± 6.9 years. Participants were randomly assigned to an intervention (IG) or control group (CG). The IG participated in a 3-month multicomponent exercise intervention focused on strength, balance, stretching exercises, and walking recommendations...
January 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29325626/fragile-x-syndrome-and-fragile-x-associated-tremor-ataxia-syndrome
#6
Deborah A Hall, Elizabeth Berry-Kravis
Fragile X-associated disorders encompass several conditions, which are caused by expansion mutations in the fragile X mental retardation 1 (FMR1) gene. Fragile X syndrome is the most common inherited etiology of intellectual disability and results from a full mutation or >200 CGG repeats in FMR1. It is associated with developmental delay, autism spectrum disorder, and seizures. Fragile X-associated tremor/ataxia syndrome is a progressive neurodegenerative disease that occurs in premutation carriers of 55-200 CGG repeats in FMR1 and is characterized by kinetic tremor, gait ataxia, parkinsonism, executive dysfunction, and neuropathy...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29325195/common-calcaneal-tenorrhaphy-revision-using-a-central-gastrocnemius-turnover-aponeurotic-flap-technique-in-a-cat
#7
Fabio Sangion, Filippo Cinti, Guido Pisani
A 5-year-old, male castrated, domestic short hair cat was referred to the authors' clinic because of wound dehiscence and exposure of tendon stumps after tenorrhaphy of the Achilles tendon. Surgical revision was done using an aponeurotic flap taken from the proximal stump of the Achilles tendon and sutured over the two tendon portions. This technique has been described in humans, but, to the authors' knowledge, this has not been reported in cats. Modified type II external fixation was used to maintain the tarsocrural joint in extension until tendon healing was confirmed ultrasonographically 35 days postoperatively...
January 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29324510/reliability-and-validity-of-computerized-force-platform-measures-of-balance-function-in-healthy-older-adults
#8
Cathy C Harro, Chelsea Garascia
BACKGROUND AND PURPOSE: Postural control declines with aging and is an independent risk factor for falls in older adults. Objective examination of balance function is warranted to direct fall prevention strategies. Force platform (FP) systems provide quantitative measures of postural control and analysis of different aspects of balance. The purpose of this study was to examine the reliability and validity of FP measures in healthy older adults. METHODS: This study enrolled 46 healthy elderly adults, mean age 67...
January 10, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29324509/investigating-the-relationship-of-the-functional-gait-assessment-to-spatiotemporal-parameters-of-gait-and-quality-of-life-of-individuals-with-stroke
#9
Richard Price, Nancy Low Choy
BACKGROUND AND PURPOSE: Walking in the community is an important aspect of independence and quality of life (QOL) that poses challenges for individuals with stroke. This study investigated whether performance on the Functional Gait Assessment (FGA) differentiated spatiotemporal gait parameters, QOL, and fall history of community-ambulating individuals with stroke. We hypothesized that those scoring higher on the FGA would present with better gait speed and cadence, stride width and length, and improved load time on the paretic limb, report a higher QOL, and be less likely to have a fall history than those who scored lower on the FGA...
January 10, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29324456/targeted-knockdown-of-bone-morphogenetic-protein-signaling-within-neural-progenitors-protects-the-brain-and-improves-motor-function-following-postnatal-hypoxia-ischemia
#10
Robert W Dettman, Derin Birch, Augusta Fernando, John A Kessler, Maria L V Dizon
Hypoxic-ischemic injury (HI) to the neonatal human brain results in myelin loss that, in some children, can manifest as cerebral palsy. Previously, we had found that neuronal overexpression of the bone morphogenic protein (BMP) inhibitor noggin during development increased oligodendroglia and improved motor function in an experimental model of HI utilizing unilateral common carotid artery ligation followed by hypoxia. As BMPs are known to negatively regulate oligodendroglial fate specification of neural stem cells and alter differentiation of committed oligodendroglia, BMP signaling is likely an important mechanism leading to myelin loss...
January 12, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29323400/-amimia-in-parkinson-s-disease-significance-and-correlation-with-the-clinical-features
#11
P J Garcia-Ruiz, C E Feliz-Feliz, T Maycas-Cepeda, J Del Val-Fernandez
INTRODUCTION: Reduced facial expression or amimia is one of the most typical characteristics of Parkinson's disease (PD). Despite being described in classic texts, its significance, physiopathology and correlation with motor and non-motor symptoms is largely unknown. PATIENTS AND METHODS: We have studied facial bradykinesia in a group of 84 de novo PD patients prospectively evaluated for five years. We also studied the relationship of facial bradykinesia with depression in a subgroup of 30 patients...
January 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29322318/total-knee-arthroplasty-with-unexplained-pain-new-insights-from-kinematics
#12
Célia Planckaert, Gabriel Larose, Pierre Ranger, Marc Lacelle, Alexandre Fuentes, Nicola Hagemeister
INTRODUCTION: Up to 20% of total knee arthroplasty patients remain unsatisfied post-surgery, and a large proportion of them report anterior knee pain. This study aims to verify whether patients who experience anterior knee pain after total knee arthroplasty (TKA) will exhibit kinematic characteristics similar to those associated with patellofemoral syndrome, including in the frontal and transverse planes. MATERIALS AND METHODS: Using four different assessment methods [radiological, patient-reported outcome, musculoskeletal assessment with functional performance testing, and a 3D kinematic assessment during gait], the clinical and 3D knee kinematic profiles of three groups were compared: a painful and an asymptomatic TKA group and a healthy control group...
January 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29318933/comparing-auditory-visual-and-vibrotactile-cues-in-individuals-with-parkinson-s-disease-for-reducing-risk-of-falling-over-different-types-of-soil
#13
Johannes C Ayena, Louis E Tremblay, Martin J-D Otis, Bob-Antoine J Ménélas
INTRODUCTION: Several researchers have demonstrated the positive benefits of auditory and visual cueing in the gait improvements among individuals with Parkinson's disease (PD). However, few studies have evaluated the role of vibrotactile cueing when compared to auditory and visual cueing. This paper compares how these stimuli affect the risk of falling while walking on six types of soil (concrete, sand, parquet, broken stone, two types of carpet). METHODS: An instrumented Timed Up and Go (iTUG) test served to evaluate how audio, visual and vibrotactile cueing can affect the risk of falling of elderly...
January 10, 2018: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29318592/falls-in-cognitively-impaired-older-adults-implications-for-risk-assessment-and-prevention
#14
Manuel Montero-Odasso, Mark Speechley
OBJECTIVES: To provide an overview of the role of cognition in falls, with potential implications for managing and preventing falls in older adults. DESIGN: Review. SETTING: Observational and interventional studies addressing the role of cognition on falls. PARTICIPANTS: Community-dwelling older adults (65 years and older). MEASUREMENTS: The relationship between gait and cognition in aging and neurodegeneration was reviewed in the medical literature to highlight the role of brain motor control deficits in fall risk...
January 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29317501/most-mutations-that-cause-spinocerebellar-ataxia-autosomal-recessive-type-16-scar16-destabilize-the-protein-quality-control-e3-ligase-chip
#15
Adam J Kanack, Oliver J Newsom, Kenneth Matthew Scaglione
The accumulation of misfolded proteins promotes protein aggregation and neuronal death in many neurodegenerative diseases. To counteract misfolded protein accumulation, neurons have pathways that recognize and refold or degrade aggregation-prone proteins. One U-box containing E3 ligase, C terminus of Hsc70-interacting protein (CHIP) plays a key role in this process, targeting misfolded proteins for proteasomal degradation. CHIP plays a protective role in mouse models of neurodegenerative disease, and in humans, mutations in CHIP cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16), a fatal neurodegenerative disease characterized by truncal and limb ataxia that result in gait instability...
January 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29316888/the-preventive-effect-of-sensorimotor-and-vibration-exercises-on-the-onset-of-oxaliplatin-or-vinca-alkaloid-induced-peripheral-neuropathies-stop
#16
Fiona Streckmann, Maryam Balke, Helmar C Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T Baumann, Wilhelm Bloch
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated with significant disability and poor recovery. Common symptoms include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29316645/technology-based-feedback-and-its-efficacy-in-improving-gait-parameters-in-patients-with-abnormal-gait-a-systematic-review
#17
REVIEW
Gema Chamorro-Moriana, Antonio José Moreno, José Luis Sevillano
This systematic review synthesized and analyzed clinical findings related to the effectiveness of innovative technological feedback for tackling functional gait recovery. An electronic search of PUBMED, PEDro, WOS, CINAHL, and DIALNET was conducted from January 2011 to December 2016. The main inclusion criteria were: patients with modified or abnormal gait; application of technology-based feedback to deal with functional recovery of gait; any comparison between different kinds of feedback applied by means of technology, or any comparison between technological and non-technological feedback; and randomized controlled trials...
January 6, 2018: Sensors
https://www.readbyqxmd.com/read/29316334/geriatric-assessment-of-physical-and-cognitive-functioning-in-a-diverse-cohort-of-systemic-lupus-erythematosus-patients-a-pilot-study
#18
Laura Plantinga, Benjamin D Tift, Charmayne Dunlop-Thomas, S Sam Lim, C Barrett Bowling, Cristina Drenkard
OBJECTIVE: To use multi-domain functional assessment, commonly performed in geriatric patients but novel among SLE patients, to better understand functional impairment in SLE. METHODS: We recruited 60 adult participants [aged 20-39 (26.7%), 40-59 (50.0%), and ≥60 (23.3%); 80.0% black; 90.0% female] from an existing cohort of SLE patients. During in-person visits (10/16-4/17), we evaluated physical performance (range 0-4; higher scores = better performance); cognitive performance (five fluid cognition domains; adjusted t-scores); and self-reported measures including physical functioning (t-scores), activities of daily living (ADLs), falls, and life-space mobility...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29310504/the-effect-of-electromagnetic-fields-on-postoperative-pain-and-locomotor-recovery-in-dogs-with-acute-severe-thoracolumbar-intervertebral-disc-extrusion-a-randomized-placebo-controlled-prospective-clinical-trial
#19
Natalia Zidan, Joe Fenn, Emily Griffith, Peter J Early, Chris L Mariani, Karen R Munana, Julien Guevar, Natasha Olby
Spinal cord injury (SCI) due to acute intervertebral disc extrusions (IVDE) is common in dogs and is treated by surgical decompression. Dogs with sensorimotor complete injuries have an incomplete recovery. Pulsed electromagnetic fields (PEMF) reduce postoperative pain through anti-inflammatory effects and there is growing evidence for neuroprotective effects. This randomized, controlled clinical trial evaluated the effect of PEMF on post-operative pain and neurologic recovery in dogs with surgically treated sensorimotor complete SCI due to acute IVDE...
January 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29305858/identification-of-a-candidate-enhancer-for-dmrt3-involved-in-spastic-cerebral-palsy-pathogenesis
#20
Naoto Kubota, Toshifumi Yokoyama, Nobuhiko Hoshi, Mikita Suyama
Cerebral palsy (CP) is a major neuronal disease and the most common movement disorder in children. Although environmental factors leading to CP have been greatly investigated, the genetic mechanism underlying CP is not well understood. Here we focused on two clinical reports that characterized a deletion involving the KANK1 gene locus in the 9p24.3 region. One report shows spastic CP and the other shows no spastic CP phenotype. Based on the epigenetic status and evolutionary conservation, we first found a functional genomic element at the noncoding region that was deleted only in patients with spastic CP...
January 3, 2018: Biochemical and Biophysical Research Communications
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