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https://www.readbyqxmd.com/read/28526935/diabetes-induced-abnormalities-of-mitochondrial-function-in-rat-brain-cortex-the-effect-of-n-3-fatty-acid-diet
#1
Maria Chomova, Maria Balazova, Jana Muchova
Diabetic encephalopathy, a proven complication of diabetes is associated with gradually developing end-organ damage in the CNS increasing the risk of stroke, cognitive dysfunction or Alzheimer's disease. This study investigated the response of rat cortical mitochondria to streptozotocin-induced diabetes and the potential for fish oil emulsion (FOE) to modulate mitochondrial function. Diabetes-induced deregulation of the respiratory chain function as a result of diminished complex I activity (CI) and cytochrome c oxidase hyperactivity was associated with attenuation of antioxidant defense of isolated cortical mitochondria, monitored by SOD activity, the thiol content, the dityrosine and protein-lipid peroxidation adduct formation...
May 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28526765/factors-associated-with-ischemic-stroke-survival-and-recovery-in-older-adults
#2
Divya Thekkethala Winovich, William T Longstreth, Alice M Arnold, Ravi Varadhan, Adina Zeki Al Hazzouri, Mary Cushman, Anne B Newman, Michelle C Odden
BACKGROUND AND PURPOSE: Little is known about factors that predispose older adults to poor recovery after a stroke. In this study, we sought to evaluate prestroke measures of frailty and related factors as markers of vulnerability to poor outcomes after ischemic stroke. METHODS: In participants aged 65 to 99 years with incident ischemic strokes from the Cardiovascular Health Study, we evaluated the association of several risk factors (frailty, frailty components, C-reactive protein, interleukin-6, and cystatin C) assessed before stroke with stroke outcomes of survival, cognitive decline (≥5 points on Modified Mini-Mental State Examination), and activities of daily living decline (increase in limitations)...
May 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28522230/cortical-microinfarcts-in-patients-with-middle-cerebral-artery-stenosis
#3
Xinyi Leng, Hui Fang, Yuehua Pu, Xinying Zou, Yuesong Pan, Yannie O Y Soo, Yuming Xu, Chunxue Wang, Xingquan Zhao, Yilong Wang, Yongjun Wang, David S Liebeskind, Lawrence K S Wong, Thomas W Leung, Liping Liu
BACKGROUND: Cortical microinfarcts (CMIs) have been correlated to cognitive decline and dementia. It was previously considered only visible on microscope, but was recently reported to be visible on 3.0 Tesla magnetic resonance imaging (MRI) and linked to presence of intracranial stenosis. We aimed to investigate CMIs on 3.0 Tesla MRI in patients with M1 middle cerebral artery (MCA-M1) stenosis. METHODS: Patients with a recent non-cardioembolic ischemic stroke or transient ischemic attack and an atherosclerotic MCA-M1 stenosis were recruited...
May 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28521701/unexpected-effects-of-acetylcholine-precursors-on-pilocarpine-seizure-induced-neuronal-death
#4
Minwoo Lee, Bo Young Choi, Sang Won Suh
Choline alfoscerate (α-GPC) and Cytidine 5'-diphosphocholine (CDP-Choline) are both acetylcholine precursors and are considered to act as pro-cholinergic nootropic agents. Acetylcholine precursors have also recently found frequent use in the neurology clinic. Stroke and many types of dementia have been shown to respond favorably after treatment with these agents, not only in terms of cognitive dysfunction but also behavioral and psychological symptoms. The primary mechanisms of Acetylcholine precursors are the following: 1) Acetylcholine precursors themselves are used in the biosynthesis of acetylcholine and 2) byproducts like glycerophosphate have protective functions for neuronal phospholipids...
May 18, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28521579/cognitive-behavioural-therapy-for-post-stroke-fatigue-and-sleep-disturbance-a-pilot-randomised-controlled-trial-with-blind-assessment
#5
Sylvia Nguyen, Dana Wong, Adam McKay, Shantha M W Rajaratnam, Gershon Spitz, Gavin Williams, Darren Mansfield, Jennie L Ponsford
The objective of this study was to evaluate the effectiveness of individual cognitive behavioural therapy (CBT) for post-stroke fatigue and sleep disturbance compared to treatment as usual (TAU). In a parallel two-group pilot randomised controlled trial of 15 participants, nine were allocated to eight weekly sessions of adapted CBT and six continued usual care rehabilitation. The primary outcome was the Fatigue Severity Scale (FSS-7) at two and four months from baseline. Secondary outcomes included measures of sleep, mood and quality of life...
May 19, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28520751/-do-it-yourself-home-blood-pressure-as-a-predictor-of-traditional-and-everyday-cognition-in-older-adults
#6
Sophie E Yeung, Wendy Loken Thornton
BACKGROUND: Hypertension guidelines recommend home blood pressure (HBP) monitoring in adjunct to office blood pressure (OBP) for its greater reproducibility and prognostic utility in the prevention of cardiovascular outcomes, especially stroke. To date, the relationship between HBP and cognitive function remains unexplored. METHODS: We examined HBP as a cognitive predictor in a multi-ethnic group of community-dwelling adults aged 60 and over (N = 133) using neuropsychological measures and analyzed the data using multiple regression analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28516810/the-role-of-meaning-in-life-mediating-the-effects-of-perceived-knowledge-of-stroke-on-depression-and-life-satisfaction-among-stroke-survivors
#7
Esther Ow Chow
OBJECTIVE: Meaning-making is a way of coping when facing adverse events. A paucity of literature suggests other possible factors (e.g. delivery of knowledge) can influence how chronic illness survivors (i.e. stroke survivors in rehabilitation) cope with illness. This article explores the importance and significance of meaning in life as a mediator between perceived stroke knowledge and psychological wellbeing among stroke survivors and how such processes can be applied in practice to promote their psychological wellbeing...
May 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28515342/clinical-presentations-and-epidemiology-of-vascular-dementia
#8
REVIEW
Eric E Smith
Cerebrovascular and cardiovascular diseases cause vascular brain injury that can lead to vascular cognitive impairment (VCI). VCI is the second most common neuropathology of dementia and mild cognitive impairment (MCI), accounting for up to one-third of the population risk. It is frequently present along with other age-related pathologies such as Alzheimer's disease (AD). Multiple etiology dementia with both VCI and AD is the single most common cause of later life dementia. There are two main clinical syndromes of VCI: post-stroke VCI in which cognitive impairment is the immediate consequence of a recent stroke and VCI without recent stroke in which cognitive impairment is the result of covert vascular brain injury detected only on neuroimaging or neuropathology...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28511786/corrigendum-to-the-neuroprotective-compound-p7c3-a20-promotes-neurogenesis-and-improves-cognitive-function-after-stroke-exp-neurol-290-2017-63-73
#9
Zachary B Loris, Andrew A Pieper, W Dalton Dietrich
No abstract text is available yet for this article.
May 13, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28510578/neurofeedback-as-a-form-of-cognitive-rehabilitation-therapy-following-stroke-a-systematic-review
#10
Tian Renton, Alana Tibbles, Jane Topolovec-Vranic
Neurofeedback therapy (NFT) has been used within a number of populations however it has not been applied or thoroughly examined as a form of cognitive rehabilitation within a stroke population. Objectives for this systematic review included: i) identifying how NFT is utilized to treat cognitive deficits following stroke, ii) examining the strength and quality of evidence to support the use of NFT as a form of cognitive rehabilitation therapy (CRT) and iii) providing recommendations for future investigations...
2017: PloS One
https://www.readbyqxmd.com/read/28506697/inflammation-and-hemostasis-in-older-octogenarians-implication-in-5-year-survival
#11
Judit Cubedo, Teresa Padró, Francesc Formiga, Assumpta Ferrer, Glòria Padrós, Esther Peña, Lina Badimon
Social changes and medical advances have increased longevity, but the conditions governing healthy vs unhealthy cardiovascular (CV) aging are not fully known. Factors beyond classical CV risk factors may have an important unrecognized value. We sought to identify proteins differentially expressed in healthy octogenarians (HOs) without a history of cardiovascular disease (CVD) and preserved functional and cognitive state compared with octogenarians with a history of CVD and cognitive decline (UHOs) using a systems biology approach, and investigated how these proteins relate to CV mortality at 5-year follow-up...
April 26, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28506018/return-to-work-predictors-of-stroke-survivors-and-their-spousal-caregivers
#12
Celia H Schulz, Kyler M Godwin, Gayle I Hersch, Leslie K Hyde, Jocelyn J Irabor, Sharon K Ostwald
BACKGROUND: Return to work is an issue of concern for stroke survivors and their spouses. Ramifications may include loss of income and self-efficacy. OBJECTIVE: This study describes the return to work patterns of stroke survivors and their spousal caregivers post stroke. METHODS: One hundred fifty-nine dyads were examined for their return to work patterns at baseline (post hospital discharge) and then at 3 month intervals for one year. Relationships were determined between work and gender, age, ethnicity, education, type of insurance, type of stroke, location of stroke, motor and cognitive functional status, depression, mutuality, and life satisfaction...
May 6, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28505995/prediction-of-post-stroke-functional-mobility%C3%A2-from-the-initial-assessment-of%C3%A2-cognitive-function
#13
Se Hee Jung, Shi-Uk Lee, Jihong Park
BACKGROUND: Cognitive impairment is frequently seen in patients with stroke. The possible correlation between cognitive function and functional mobility has been proposed; however, the prognostic importance of early cognitive function in recovery of mobility has not been investigated in patients with stroke. OBJECTIVE: The objective of this study is to investigate whether the cognitive function in the acute phase can independently predict the recovery of mobility after stroke, and to determine the cut-off value of each cognitive evaluation test for community ambulation at six months...
May 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28504943/towards-multimodal-human-robot-interaction-to-enhance-active-participation-of-users-in-gait-rehabilitation
#14
Kai Gui, Honghai Liu, Dingguo Zhang
Robotic exoskeletons for physical rehabilitation have been utilized for retraining patients suffering from paraplegia and enhancing motor recovery in recent years. However, users are not voluntarily involved in most systems. This work aims to develop a locomotion trainer with multiple gait patterns, which can be controlled by the active motion intention of users. A multimodal human-robot interaction (HRI) system is established to enhance subject's active participation during gait rehabilitation, which includes cognitive human-robot interaction (cHRI) and physical human-robot interaction (pHRI)...
May 11, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28500860/interventions-for-preventing-silent-cerebral-infarcts-in-people-with-sickle-cell-disease
#15
REVIEW
Lise J Estcourt, Patricia M Fortin, Sally Hopewell, Marialena Trivella, Carolyn Doree, Miguel R Abboud
BACKGROUND: Sickle cell disease (SCD) is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Silent cerebral infarcts are the commonest neurological complication in children and probably adults with SCD. Silent cerebral infarcts also affect academic performance, increase cognitive deficits and may lower intelligence quotient...
May 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28499951/effects-of-task-specific-rehabilitation-training-on-tau-modification-in-rat-with-photothrombotic-cortical-ischemic-damage
#16
Kyung-Lim Joa, Sohee Moon, Ji-Hye Kim, Dong Wun Shin, Kyoung-Hee Lee, Seon Jung, Myeong-Ok Kim, Chang-Hwan Kim, Han-Young Jung, Ju-Hee Kang
Although stroke elicits progressive cognitive decline and is a leading cause of dementia, molecular interplay between stroke and Alzheimer's disease (AD) pathology has not been fully elucidated. Furthermore, studies on the effects of post-stroke rehabilitation on AD pathology are limited. We evaluated the acute effect of stroke on tau modification, and the molecular effects of task-specific training (TST) on tau modification using a model of photochemically-induced thrombosis (PIT)-induced cortical infarction...
May 9, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28499387/evolution-of-the-fourth-stage-of-epidemiologic-transition-in-people-aged-80%C3%A2-years-and-over-population-based-cohort-study-using-electronic-health-records
#17
Nisha C Hazra, Martin Gulliford
BACKGROUND: In the "fourth stage" of epidemiological transition, the distribution of non-communicable diseases is expected to shift to more advanced ages, but age-specific changes beyond 80 years of age have not been reported. METHODS: This study aimed to evaluate demographic and health transitions in a population aged 80 years and over in the United Kingdom from 1990 to 2014, using primary care electronic health records. Epidemiological analysis of chronic morbidities and age-related impairments included a cohort of 299,495 participants, with stratified sampling by five-year age group up to 100 years and over...
May 12, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28498008/spatial-orientation-and-navigation-in-children-with-perinatal-stroke
#18
Kara Murias, Adam Kirton, Sana Tariq, Adrian Gil Castillejo, Andrea Moir, Giuseppe Iaria
As a focal injury in an otherwise healthy child, perinatal stroke provides a clinical model of developmental brain plasticity. In this study, we report evidence that children with perinatal periventricular venous infarcts perform as well as control children on a video game that tests navigation abilities. In addition, children with a history of perinatal arterial strokes overcame initial deficits in navigation performance after additional practice. These findings lend support to the hypothesis that a complex cognitive skill dependent on a distributed neural network with prolonged maturation, such as navigation, may demonstrate resilience after early brain injury...
May 12, 2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/28497797/suppression-of-cognitive-function-in-hyperthermia-from-the-viewpoint-of-executive-and-inhibitive-cognitive-processing
#19
Manabu Shibasaki, Mari Namba, Misaki Oshiro, Ryusuke Kakigi, Hiroki Nakata
Climate change has had a widespread impact on humans and natural systems. Heat stroke is a life-threatening condition in severe environments. The execution or inhibition of decision making is critical for survival in a hot environment. We hypothesized that, even with mild heat stress, not only executive processing, but also inhibitory processing may be impaired, and investigated the effectiveness of body cooling approaches on these processes using the Go/No-go task with electroencephalographic event-related potentials...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495601/structural-connectivity-subserving-verbal-fluency-revealed-by-lesion-behavior-mapping-in-stroke-patients
#20
Mingyang Li, Yumei Zhang, Luping Song, Ruiwang Huang, Junhua Ding, Yuxing Fang, Yangwen Xu, Zaizhu Han
Tests of verbal fluency have been widely used to assess the cognitive functioning of persons, and are typically classified into two categories (semantic and phonological fluency). While widely-distributed divergent and convergent brain regions have been found to be involved in semantic and phonological fluency, the anatomical connectivity underlying the fluency is not well understood. The present study aims to construct a comprehensive white-matter network associated with semantic and phonological fluency by investigating the relationship between the integrity of 22 major tracts in the whole brain and semantic fluency (measured by 3 cues) and phonological fluency (measured by 2 cues) in a group of 51 stroke patients...
May 8, 2017: Neuropsychologia
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