keyword
MENU ▼
Read by QxMD icon Read
search

GDF

keyword
https://www.readbyqxmd.com/read/28440431/gdf-15-gene-expression-alterations-in-human-lymphoblastoid-cells-and-peripheral-blood-lymphocytes-following-exposure-to-ionizing-radiation
#1
Shuang Li, Qing-Zhao Zhang, De-Qin Zhang, Jiang-Bin Feng, Qun Luo, Xue Lu, Xin-Ru Wang, Kun-Peng Li, De-Qing Chen, Xiao-Feng Mu, Ling Gao, Qing-Jie Liu
The identification of rapid, sensitive and high‑throughput biomarkers is imperative in order to identify individuals harmed by radiation accidents, and accurately evaluate the absorbed doses of radiation. DNA microarrays have previously been used to evaluate the alterations in growth/differentiation factor 15 (GDF15) gene expression in AHH‑1 human lymphoblastoid cells, following exposure to γ‑rays. The present study aimed to characterize the relationship between the dose of ionizing radiation and the produced effects in GDF‑15 gene expression in AHH‑1 cells and human peripheral blood lymphocytes (HPBLs)...
April 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28430124/association-between-serum-selenium-concentrations-and-levels-of-proinflammatory-and-profibrotic-cytokines-interleukin-6-and-growth-differentiation-factor-15-in-patients-with-alcoholic-liver-cirrhosis
#2
Andrzej Prystupa, Paweł Kiciński, Dorota Luchowska-Kocot, Anna Błażewicz, Jarosław Niedziałek, Grzegorz Mizerski, Mariusz Jojczuk, Andrzej Ochal, Jarosław J Sak, Wojciech Załuska
According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines-interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria...
April 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28426571/growth-differentiation-factor-5-accelerates-wound-closure-and-improves-skin-quality-during-repair-of-full-thickness-skin-defects
#3
Jennifer L Schiefer, Manuel Held, Paul C Fuchs, Erhan Demir, Frank Plöger, Hans-Eberhard Schaller, Afshin Rahmanian-Schwarz
BACKGROUND: A fast and stable wound closure is important, especially for extended and unstable wounds found after burn injuries. Growth can regulate a variety of cellular processes, including those involved in wound healing. Growth differentiation factor 5 (GDF-5) can accelerate fibroblast cell migration, cell proliferation, and collagen synthesis, which are essential for wound healing. Nevertheless, no standardized evaluation of the effect of GDF-5 on the healing of full-thickness wounds has been published to date...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28411246/growth-differentiation-factor-15-at-1%C3%A2-month-after-an-acute-coronary-syndrome-is-associated-with-increased-risk-of-major-bleeding
#4
Daniel Lindholm, Emil Hagström, Stefan K James, Richard C Becker, Christopher P Cannon, Anders Himmelmann, Hugo A Katus, Gerald Maurer, José Luis López-Sendón, Philippe Gabriel Steg, Robert F Storey, Agneta Siegbahn, Lars Wallentin
BACKGROUND: Growth differentiation factor-15 (GDF-15) is related to major bleeding when measured at initial presentation in patients with acute coronary syndromes (ACSs) treated with dual antiplatelet therapy. It is unknown whether follow-up measurements provide additional information. The objective of this study was to investigate whether GDF-15 measured 1 month after an ACS provides additional information beyond the baseline levels with regard to the risk of major bleeding. METHODS AND RESULTS: GDF-15 was measured at baseline and at 1 month after an ACS in 4049 patients included in the PLATelet inhibition and patient Outcomes (PLATO) trial...
April 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28389123/circulating-gdf-15-levels-predict-future-secondary-manifestations-of-cardiovascular-disease-explicitly-in-women-but-not-men-with-atherosclerosis
#5
Aisha Gohar, Isabel Gonçalves, Joyce Vrijenhoek, Saskia Haitjema, Ian van Koeverden, Jan Nilsson, Gert J de Borst, Jean-Paul de Vries, Gerard Pasterkamp, Hester M den Ruijter, Harry Björkbacka, Saskia C A de Jager
BACKGROUND: Elevated serum levels of growth differentiation factor-15 (GDF-15), is an established risk factor for a range of cardiovascular diseases. We aimed to evaluate the predictive value of plasma GDF-15 as a biomarker for secondary cardiovascular events (CVE) in patients with atherosclerosis undergoing carotid endarterectomy (CEA). Secondly, we determined whether plasma GDF-15 was associated with carotid plaque characteristics. METHODS: Circulating GDF-15 levels were determined by Luminex assay in a cohort of 1056 patients from the Athero-Express biobank...
March 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28385068/transforming-growth-factor-15-increased-in-severe-aplastic-anemia-patients
#6
Yuanyuan Shao, Honglei Wang, Chunyan Liu, Qiuying Cao, Rong Fu, Huaquan Wang, Ting Wang, Weiwei Qi, Zonghong Shao
OBJECTIVES: The patients with severe aplastic anemia (SAA) usually rely on red cell transfusion which lead to secondary iron overload. Transforming growth differentiation factor-15 (GDF-15) plays an important role in erythropoiesis and iron regulation. In this study, we investigated the level of GDF-15 and other indexes of iron metabolism in SAA patients to explore the correlation with GDF-15 and iron overload in SAA. METHODS: The levels of serum GDF-15, hepcidin (Hepc), and erythropoietin (EPO) were determined by ELISA...
April 6, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28367413/expression-of-folliculogenesis-related-genes-in-vitrified-human-ovarian-tissue-after-two-weeks-in-vitro-culture
#7
Zahra Shams Mofarahe, Mojdeh Salehnia, Marefat Ghaffari Novin, Nassim Ghorbanmehr, Mohammad Gholami Fesharaki
OBJECTIVE: This study was designed to evaluate the effects of vitrification and in vitro culture of human ovarian tissue on the expression of oocytic and follicular cell-related genes. MATERIALS AND METHODS: In this experimental study, ovarian tissue samples were obtained from eight transsexual women. Samples were cut into small fragments and were then assigned to vitrified and non-vitrified groups. In each group, some tissue fragments were divided into un-cultured and cultured (in α-MEM medium for 2 weeks) subgroups...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28359091/bmp15-mutations-associated-with-primary-ovarian-insufficiency-reduce-expression-activity-or-synergy-with-gdf9
#8
Liliana C Patiño, Kelly L Walton, Thomas D Mueller, Katharine E Johnson, William Stocker, Dulama Richani, David Agapiou, Robert B Gilchrist, Paul Laissue, Craig A Harrison
Context: Bone morphogenetic protein (BMP)15 is an oocyte-specific growth factor, which, together with growth differentiation factor (GDF) 9, regulates folliculogenesis and ovulation rate. Multiple mutations in BMP15 have been identified in women with primary ovarian insufficiency (POI), supporting a pathogenic role; however, the underlying biological mechanism of many of these mutants remains unresolved. Objectives: To determine how mutations associated with ovarian dysfunction alter the biological activity of human BMP15...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28346732/asiaticoside-hinders-the-invasive-growth-of-keloid-fibroblasts-through-inhibition-of-the-gdf-9-mapk-smad-pathway
#9
Xin Wu, Difei Bian, Yannong Dou, Zhunan Gong, Qian Tan, Yufeng Xia, Yue Dai
Higher expression of growth differentiation factor-9 (GDF-9) in keloids compared with hypertrophic scars and normal skin tissues has been reported recently. The present study was performed to investigate the role of GDF-9 in keloid pathogenesis, and to elucidate its implication for asiaticoside in the keloid management. The data showed that GDF-9 could enhance the proliferation, migration, and invasion of keloid fibroblasts (KFs), while it only slightly elevated collagen expression, indicating that the effect of GDF-9 was opposite to that of TGF-β1...
March 27, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28341782/predictive-properties-of-biomarkers-gdf-15-ntprobnp-and-hs-tnt-on-morbidity-and-mortality-in-type-2-diabetes-patients-with-nephropathy
#10
Arash Bidadkosh, Sebastiaan P H Lambooy, Hiddo J Heerspink, Michelle J Pena, Robert H Henning, Hendrik Buikema, Leo E Deelman
OBJECTIVE: Although type 2 diabetes (T2D) patients with nephropathy are at high risk for renal and cardiovascular complications, relevant biomarkers have been poorly identified. Because renal impairment may increase biomarker levels, this potentially confounds associations between biomarker levels and risk. To investigate the predictive value of a biomarker in such a setting, we examined baseline levels of growth differentiation factor-15 (GDF-15), N-terminal prohormone of B-type natriuretic peptide (NTproBNP), and high-sensitivity troponin-T (hs-TnT) in relation to renal and cardiovascular risk in T2D patients with nephropathy...
March 24, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28315120/prognostic-biomarkers-in-acute-coronary-syndromes-risk-stratification-beyond-cardiac-troponins
#11
REVIEW
K M Eggers, B Lindahl
PURPOSE OF REVIEW: Cardiac troponin (cTn) plays an essential role for assessment of outcome in acute coronary syndrome (ACS). However, the prognostic value of cTn is not absolute. In this mini-review, we summarize the evidence on the utility of established biomarkers of left-ventricular dysfunction, hemodynamic stress, inflammation, and renal dysfunction for risk prediction beyond cTn in ACS. RECENT FINDINGS: Only few biomarkers consistently demonstrate additive prognostic value to cTn levels...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28301573/panel-of-three-novel-serum-markers-predicts-liver-stiffness-and-fibrosis-stages-in-patients-with-chronic-liver-disease
#12
Marcin Krawczyk, Simone Zimmermann, Georg Hess, Robert Holz, Marc Dauer, Jochen Raedle, Frank Lammert, Frank Grünhage
Latest data suggest that placental growth factor (PLGF), growth differentiation factor-15 (GDF-15) and hepatic growth factor (HGF) are involved in hepatic fibrogenesis. Diagnostic performance of these markers for non-invasive liver fibrosis prediction was evaluated based on liver histology and stiffness. In total 834 patients were recruited. Receiver-operating-characteristics were used to define cut-offs for markers correlating to fibrosis stages. Odds-ratios were calculated for the presence/absence of fibrosis/cirrhosis and confirmed in the sub-group of patients phenotyped by elastography only...
2017: PloS One
https://www.readbyqxmd.com/read/28287848/immunomodulating-and-immunoresistance-properties-of-cancer-initiating-cells-implications-for-the-clinical-success-of-immunotherapy
#13
REVIEW
Cristina Maccalli, Giorgio Parmiani, Soldano Ferrone
Cancer-initiating cells (CICs) represent a relatively rare subpopulation of cells endowed with self-renewal, stemness properties, tumorigenicity in immunodeficient mice, and resistance to standard therapies as well as to immunotherapy. Here, we review the biological and immunological characteristics of CICs with special focus on the immunomodulating mechanisms they utilize to escape from immunosurveillance. The recently developed immunotherapeutic strategies have yielded remarkable clinical results in many types of tumors, indicating that indeed a patient's immune system can mount an immune response, which is effective in controlling tumor growth...
April 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28283847/increased-plasma-concentrations-of-soluble-st2-independently-predict-mortality-but-not-cardiovascular-events-in-stable-coronary-heart-disease-patients-13-year-follow-up-of-the-karola-study
#14
Vanessa Pfetsch, Veronika Sanin, Andrea Jaensch, Dhayana Dallmeier, Ute Mons, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
PURPOSE: sST2 (soluble suppression of tumorigenicity 2), a member of the interleukin-1 family, has been suggested to play a role in cardiac remodeling and inflammatory signaling. We assessed the association between sST2 in patients with stable coronary heart disease (CHD) with multiple cardiovascular outcomes and total mortality, simultaneously controlling for a large number of potential confounders. METHODS: Plasma concentrations of sST2 (ELISA, Critical Diagnostics) were measured at baseline in a cohort of 1081 patients...
March 10, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28270449/supraphysiological-levels-of-gdf11-induce-striated-muscle-atrophy
#15
David W Hammers, Melissa Merscham-Banda, Jennifer Ying Hsiao, Stefan Engst, James J Hartman, H Lee Sweeney
Growth and differentiation factor (GDF) 11 is a member of the transforming growth factor β superfamily recently identified as a potential therapeutic for age-related cardiac and skeletal muscle decrements, despite high homology to myostatin (Mstn), a potent negative regulator of muscle mass. Though several reports have refuted these data, the in vivo effects of GDF11 on skeletal muscle mass have not been addressed. Using in vitro myoblast culture assays, we first demonstrate that GDF11 and Mstn have similar activities/potencies on activating p-SMAD2/3 and induce comparable levels of differentiated myotube atrophy...
April 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28245821/gdf-15-plasma-levels-in-chronic-obstructive-pulmonary-disease-are-associated-with-subclinical-coronary-artery-disease
#16
Carlos H Martinez, Christine M Freeman, Joshua D Nelson, Susan Murray, Xin Wang, Matthew J Budoff, Mark T Dransfield, John E Hokanson, Ella A Kazerooni, Gregory L Kinney, Elizabeth A Regan, J Michael Wells, Fernando J Martinez, MeiLan K Han, Jeffrey L Curtis
BACKGROUND: Growth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unknown. We tested associations between GDF-15 and subclinical coronary atherosclerosis, assessed by coronary artery calcium (CAC) score, in COPD subjects free of clinical cardiovascular disease (CVD). METHODS: Cross-sectional analysis of COPD participants (GOLD stages 2-4) in the COPDGene cohort without CVD at enrollment, using baseline CAC (from non-EKG-gated chest computed tomography) and plasma GDF-15 (by custom ELISA)...
February 28, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28223232/the-versatility-and-paradox-of-gdf-11
#17
REVIEW
A Jamaiyar, W Wan, D M Janota, M K Enrick, W M Chilian, L Yin
In addition to its roles in embryonic development, Growth and Differentiation Factor 11 (GDF 11) has recently drawn much interest about its roles in other processes, such as aging. GDF 11 has been shown to play pivotal roles in the rescue of the proliferative and regenerative capabilities of skeletal muscle, neural stem cells and cardiomyocytes. We would be remiss not to point that some controversy exists regarding the role of GDF 11 in biological processes and whether it will serve as a therapeutic agent. The latest studies have shown that the level of circulating GDF 11 correlates with the outcomes of patients with cardiovascular diseases, cancer and uremia...
February 14, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28217814/-effects-of-growth-differentiation-factor-15-gdf-15-on-neurological-systems-cardiovascular-diseases-and-cancer-progression
#18
Dong-Dong Liu, Yan-Ai Mei
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. It has been suggested that GDF-15 has neurotropic effects in the nervous system. Our studies showed that GDF-15 modulated the expression of neuronal K(+) and Ca(2+) ion channels and increased the release of excitatory transmitter in the medial prefrontal cortex of mice...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28212715/novel-biomarkers-of-heart-failure
#19
A Savic-Radojevic, M Pljesa-Ercegovac, M Matic, D Simic, S Radovanovic, T Simic
Although substantial improvements have been made in majority of cardiac disorders, heart failure (HF) remains a major health problem, with both increasing incidence and prevalence over the past decades. For that reason, the number of potential biomarkers that could contribute to diagnosis and treatment of HF patients is, almost exponentially, increasing over the recent years. The biomarkers that are, at the moment, more or less ready for use in everyday clinical practice, reflect different pathophysiological processes present in HF...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28206960/an-autocrine-paracrine-circuit-of-growth-differentiation-factor-gdf-15-has-a-role-for-maintenance-of-breast-cancer-stem-like-cells
#20
Asako Sasahara, Kana Tominaga, Tatsunori Nishimura, Masao Yano, Etsuko Kiyokawa, Miki Noguchi, Masakuni Noguchi, Hajime Kanauchi, Toshihisa Ogawa, Hiroshi Minato, Keiichiro Tada, Yasuyuki Seto, Arinobu Tojo, Noriko Gotoh
Cancer stem cells are thought to be responsible for tumor growth, recurrence, and resistance to conventional cancer therapy. However, it is still unclear how they are maintained in tumor tissues. Here, we show that the growth differentiation factor 15 (GDF15), a member of the TGFβ family, may maintain cancer stem-like cells in breast cancer tissues by inducing its own expression in an autocrine/paracrine manner. We found that GDF15, but not TGFβ, increased tumor sphere formation in several breast cancer cell lines and patient-derived primary breast cancer cells...
April 11, 2017: Oncotarget
keyword
keyword
98879
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"