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https://www.readbyqxmd.com/read/29791474/growth-differentiation-factor-15-levels-and-the-risk-of-contrast-induced-nephropathy-in-patients-with-acute-myocardial-infarction-undergoing-percutaneous-coronary-intervention-a-retrospective-observation-study
#1
Ling Sun, Xuejun Zhou, Jianguang Jiang, Xuan Zang, Xin Chen, Haiyan Li, Haitao Cao, Qingjie Wang
AIMS: To investigate the association between growth differentiation factor-15 (GDF-15) and contrast-induced nephropathy (CIN) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). METHODS: A total of 311 patients with AMI were studied retrospectively. All patients were divided into two groups according to the occurrence of CIN after PCI. Baseline clinical data were compared between two groups. Multivariate logistic regression analysis was used to identify the risk factors for CIN...
2018: PloS One
https://www.readbyqxmd.com/read/29779014/current-insights-on-use-of-growth-factors-as-therapy-for-intervertebral-disc-degeneration
#2
Justin C Kennon, Mohamed E Awad, Norman Chutkan, John DeVine, Sadanand Fulzele
Chronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential methods for inhibiting or reversing IVD degeneration, which have previously been impossible. The use of growth factors is under serious consideration as a potential therapy to enhance IVD tissue regeneration. We reviewed the role of chosen prototypical growth factors and growth factor combinations that have the capacity to improve IVD restoration...
May 19, 2018: Biomolecular Concepts
https://www.readbyqxmd.com/read/29771963/predictive-value-of-long-term-changes-of-growth-differentiation-factor-15-over-a-27-year-period-for-heart-failure-and-death-due-to-coronary-heart-disease
#3
Nina Fluschnik, Francisco Ojeda, Tanja Zeller, Torben Jørgensen, Kari Kuulasmaa, Peter Moritz Becher, Christoph Sinning, Stefan Blankenberg, Dirk Westermann
BACKGROUND: Growth differentiation factor-15 (GDF-15), Cystatin C and C-reactive protein (CRP) have been discussed as biomarkers for prediction of cardiac diseases. The aim of this study was to investigate the predictive value of single and repeated measurements of GDF-15 compared to Cystatin C and CRP for incidence of heart failure (HF) and death due to coronary heart disease (CHD) in the general population. METHODS AND RESULTS: Levels of GDF-15, CRP and Cystatin C were determined in three repeated measurements collected 5 years apart in the DAN-MONICA (Danish-Multinational MONitoring of trends and determinants in Cardiovascular disease) cohort (participants at baseline n = 3785)...
2018: PloS One
https://www.readbyqxmd.com/read/29737871/circulating-biomarkers-of-hypertrophy-and-fibrosis-in-patients-with-hypertrophic-cardiomyopathy-assessed-by-cardiac-magnetic-resonance
#4
Monika Gawor, Mateusz Śpiewak, Agata Kubik, Aleksandra Wróbel, Anna Lutyńska, Magdalena Marczak, Jacek Grzybowski
PURPOSE: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. METHODS: Levels of biomarkers: soluble ST2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15), NT-proBNP, and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29723864/enrichment-of-female-germline-stem-cells-from-mouse-ovaries-using-the-differential-adhesion-method
#5
Meng Wu, Jiaqiang Xiong, Lingwei Ma, Zhiyong Lu, Xian Qin, Aiyue Luo, Jinjin Zhang, Huan Xie, Wei Shen, Shixuan Wang
BACKGROUND/AIMS: The isolation and establishment of female germline stem cells (FGSCs) is controversial because of questions regarding the reliability and stability of the isolation method using antibody targeting mouse vasa homologue (MVH), and the molecular mechanism of FGSCs self-renewal remains unclear. Thus, there needs to be a simple and reliable method for sorting FGSCs to study them. METHODS: We applied the differential adhesion method to enrich FGSCs (DA-FGSCs) from mouse ovaries...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29714603/growth-differentiation-factor-15-in-a-community-based-sample-age-dependent-reference-limits-and-prognostic-impact
#6
Steven Doerstling, Pär Hedberg, John Öhrvik, Jerzy Leppert, Egil Henriksen
BACKGROUND: Despite the growing body of evidence on growth differentiation factor 15 (GDF-15) reference values for patients with existing cardiovascular disease, limited investigation has been dedicated to characterizing the distribution and prognostic impact of GDF-15 in predominantly healthy populations. Furthermore, current cutoff values for GDF-15 fail to account for the well-documented age-dependence of circulating GDF-15. METHODS: From 810 community-dwelling older adults, we selected a group of apparently healthy participants (n = 268)...
May 1, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29698460/growth-differentiation-factor-15-and-fibroblast-growth-factor-23-are-associated-with-mortality-in-type-2-diabetes-an-observational-follow-up-study
#7
Marie Frimodt-Møller, Bernt Johan von Scholten, Henrik Reinhard, Peter Karl Jacobsen, Tine Willum Hansen, Frederik Ivar Persson, Hans-Henrik Parving, Peter Rossing
OBJECTIVES: Two biomarkers, growth differentiation factor 15 (GDF-15) and fibroblast growth factor 23 (FGF-23)), reflecting different aspects of renal pathophysiology, were evaluated as determinants of decline in estimated glomerular filtration rate (eGFR), incident cardiovascular disease (CVD) and all-cause mortality in patients with type 2 diabetes (T2D) and microalbuminuria, but without clinical cardiac disease. MATERIALS AND METHODS: Prospective study including 200 T2D patients...
2018: PloS One
https://www.readbyqxmd.com/read/29695834/contribution-of-three-dimensional-architecture-and-tumor-associated-fibroblasts-to-hepcidin-regulation-in-breast-cancer
#8
Nicole Blanchette-Farra, Daniel Kita, Anna Konstorum, Lia Tesfay, David Lemler, Poornima Hegde, Kevin P Claffey, Frank M Torti, Suzy V Torti
Hepcidin is a peptide hormone that negatively regulates iron efflux and plays an important role in controlling the growth of breast tumors. In patients with breast cancer, the combined expression of hepcidin and its membrane target, ferroportin, predict disease outcome. However, mechanisms that control hepcidin expression in breast cancer cells remain largely unknown. Here, we use three-dimensional breast cancer spheroids derived from cell lines and breast cancer patients to probe mechanisms of hepcidin regulation in breast cancer...
April 26, 2018: Oncogene
https://www.readbyqxmd.com/read/29682806/biomarkers-for-heart-failure-small-molecules-with-high-clinical-relevance
#9
REVIEW
C Magnussen, S Blankenberg
Heart failure (HF) is a rising epidemic due to the ageing population and progress in all areas of medicine. Thus, research efforts are made to ensure a timely diagnosis, to improve prognosis and treatment of the disease and to facilitate risk prediction at the population level. Because of their noninvasive determination with mostly high sensitivity and accuracy, circulating blood biomarkers are becoming increasingly important for daily clinical practice. Natriuretic peptides, especially B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and midregional pro-atrial natriuretic peptide (MR-proANP) and cardiac troponins are established blood biomarkers in HF diagnosis and prognosis of HF-related outcomes...
April 22, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29682097/growth-differentiation-factor-15-as-a-predictor-of-idiopathic-membranous-nephropathy-progression-a-retrospective-study
#10
Young Rok Ham, Chang Hun Song, Hong Jin Bae, Jin Young Jeong, Min-Kyung Yeo, Dae Eun Choi, Ki-Ryang Na, Kang Wook Lee
Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic syndrome. No biomarker to predict the long-term prognosis of IMN is currently available. Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor- β superfamily and has been associated with chronic inflammatory disease. It has the potential to be a useful prognostic marker in patients with renal diseases, such as diabetic nephropathy and IgA nephropathy. This study examined whether GDF-15 is associated with the clinical parameters in IMN and showed that GDF-15 can predict IMN disease progression...
2018: Disease Markers
https://www.readbyqxmd.com/read/29663841/novel-heart-failure-biomarkers-why-do-we-fail-to-exploit-their-potential
#11
Arnold Piek, Weijie Du, Rudolf A de Boer, Herman H W Silljé
Plasma biomarkers are useful tools in the diagnosis and prognosis of heart failure (HF). In the last decade, numerous studies have aimed to identify novel HF biomarkers that would provide superior and/or additional diagnostic, prognostic, or stratification utility. Although numerous biomarkers have been identified, their implementation in clinical practice has so far remained largely unsuccessful. Whereas cardiac-specific biomarkers, including natriuretic peptides (ANP and BNP) and high sensitivity troponins (hsTn), are widely used in clinical practice, other biomarkers have not yet proven their utility...
April 17, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29652651/prediction-of-organ-involvement-in-systemic-sclerosis-by-serum-biomarkers-and-peripheral-endothelial-function
#12
Shin-Ya Kawashiri, Ayako Nishino, Takashi Igawa, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Akitomo Okada, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Munetoshi Nakashima, Akinari Mizokami, Naoki Matsuoka, Kiyoshi Migita, Fumihide Ogawa, Satoshi Ikeda, Koji Maemura, Hideki Nakamura, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami
OBJECTIVES: To identify prognostic factors among serum biomarkers and endothelial vasodilator function findings in patients with systemic sclerosis (SSc). METHODS: This is a clinical observational study. We assessed 60 consecutive SSc patients (44 limited cutaneous-type, 16 diffuse cutaneous-type). Circulating growth differentiation factor-15 (GDF-15), placenta growth factor (PlGF), endostatin, vascular endothelial growth factor (VEGF), and pentraxin 3 (PTX3) were measured by ELISA...
April 12, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29652038/analysis-of-novel-cardiovascular-biomarkers-in-patients-with-peripheral-artery-disease-pad
#13
Peter Jirak, Moritz Mirna, Bernhard Wernly, Vera Paar, Marcus Thieme, Stefan Betge, Marcus Franz, Uta Hoppe, Alexander Lauten, Jürgen Kammler, Paul C Schulze, Michael Lichtenauer, Daniel Kretzschmar
BACKGROUND: Peripheral artery disease (PAD) is a common form of manifestation of atherosclerosis. PAD has a considerable impact on morbidity, hospitalisation rates and health- care costs. Biomarkers have been introduced in many cardiovascular disease entities over the last years. However, an analysis on the correlation of biomarker levels and PAD is still lacking. METHODS: A total of 106 patients were enrolled in this current study, 51 that were diagnosed with PAD and 55 with excluded coronary and peripheral artery disease as controls...
April 12, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29628937/a-meta-analysis-of-genome-wide-association-studies-of-growth-differentiation-factor-15-concentration-in-blood
#14
Jiyang Jiang, Anbupalam Thalamuthu, Jennifer E Ho, Anubha Mahajan, Weronica E Ek, David A Brown, Samuel N Breit, Thomas J Wang, Ulf Gyllensten, Ming-Huei Chen, Stefan Enroth, James L Januzzi, Lars Lind, Nicola J Armstrong, John B Kwok, Peter R Schofield, Wei Wen, Julian N Trollor, Åsa Johansson, Andrew P Morris, Ramachandran S Vasan, Perminder S Sachdev, Karen A Mather
Blood levels of growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), have been associated with various pathological processes and diseases, including cardiovascular disease and cancer. Prior studies suggest genetic factors play a role in regulating blood MIC-1/GDF-15 concentration. In the current study, we conducted the largest genome-wide association study (GWAS) to date using a sample of ∼5,400 community-based Caucasian participants, to determine the genetic variants associated with MIC-1/GDF-15 blood concentration...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29620815/a-descriptive-study-of-patients-receiving-foundational-financial-assistance-through-local-specialty-pharmacies
#15
Julia Zhu, Randall Odebralski, Safia Boghani, Clorinda Walley, Frank Koen, Chad Conley, Heather S Kirkham
OBJECTIVES: To describe the population of patients who received financial assistance from the Good Days Foundation (GDF) as facilitated by Walgreens local specialty pharmacies (LSPs). STUDY DESIGN: This was a retrospective descriptive study. METHODS: This study used a joint foundational and pharmacy claim database between January 1, 2014, and December 31, 2016. RESULTS: Among 1572 eligible patients who received GDF financial assistance as facilitated by Walgreens LSPs, 1524 had disease state information and 14 of these patients receveived financial assistance for 2 disease states (patient count denominator, 1538)...
March 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29615435/association-of-biomarker-clusters-with-cardiac-phenotypes-and-mortality-in-patients-with-hiv-infection
#16
Rebecca Scherzer, Sanjiv J Shah, Eric Secemsky, Javed Butler, Carl Grunfeld, Michael G Shlipak, Priscilla Y Hsue
BACKGROUND: Although individual cardiac biomarkers are associated with heart failure risk and all-cause mortality in HIV-infected individuals, their combined use for prediction has not been well studied. METHODS AND RESULTS: Unsupervised k-means cluster analysis was performed blinded to the study outcomes in 332 HIV-infected participants on 8 biomarkers: ST2, NT-proBNP (N-terminal pro-B-type natriuretic peptide), hsCRP (high-sensitivity C-reactive protein), GDF-15 (growth differentiation factor 15), cystatin C, IL-6 (interleukin-6), D-dimer, and troponin...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29607212/further-evidence-of-accelerated-aging-in-bipolar-disorder-focus-on-gdf-15
#17
Fang Yang, Izabela G Barbosa, Erica L Vieira, Moises E Bauer, Natalia P Rocha, Antonio L Teixeira
Background: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. Methods: Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study...
2018: Translational Neuroscience
https://www.readbyqxmd.com/read/29545889/overexpression-of-growth-and-differentiation-factor-5-inhibits-inflammatory-factors-released-by-intervertebral-disc-cells
#18
Lin Shen, Yinghua Wu, Liang Han, Haiying Zhang
Low back pain (LBP) is one of the most common musculoskeletal diseases in the world. The incidence is ~70% in adults and many of them suffer from disability. Recently, intervertebral disc degeneration (IDD) has been deemed as a main cause of LBP. The present study aimed to investigate the potentials of growth and differentiation factor-5 (GDF-5) in IDD. The protein levels of prostaglandin-E2 (PGE2), tumor necrosis factor (TNF)-α and interleukin (IL)-1β in culture medium were evaluated by ELISA. mRNA and protein expression levels in nucleus pulposus (NP) cells were evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting, respectively...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29535644/differing-effects-of-younger-and-older-human-plasma-on-c2c12-myocytes-in-vitro
#19
Ifigeneia Kalampouka, Angel van Bekhoven, Bradley T Elliott
Ageing is associated with a general reduction of physiological function and a reduction of muscle mass and strength. Endocrine factors such as myostatin, activin A, growth and differentiation factor 11 (GDF-11) and their inhibitory peptides influence muscle mass in health and disease. We hypothesised that myocytes cultured in plasma from older and younger individuals would show an ageing effect, with reduced proliferation and differentiation in older environments. C2C12 myoblasts were grown as standard and stimulated with media conditioned with 5% plasma from healthy male participants that were either younger ( n = 6, 18-35 years of age) or older ( n = 6, >57 years of age)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29534827/effects-of-immunization-against-bone-morphogenetic-protein-15-and-growth-differentiation-factor-9-on-ovarian-function-in-mares
#20
Kelli A Davis, Kristin M Klohonatz, Darcy S O Mora, Hannah M Twenter, Peter E Graham, Pablo Pinedo, Douglas C Eckery, Jason E Bruemmer
Currently there is no contraceptive vaccine that can cause permanent sterility in mares. This study investigates the effect of vaccination against oocyte-specific growth factors, Bone Morphogenetic Protein 15 (BMP-15) and Growth Differentiation Factor 9 (GDF-9), on ovarian function of mares. It was hypothesized that immunization against these growth factors would prevent ovulation and/or accelerate depletion of the oocyte reserve. For this study, 30 mares were randomly assigned to three groups (n = 10/group) and vaccinated with BMP-15 or GDF-9 peptides conjugated to KLH and adjuvant, or a control of phosphate buffered saline and adjuvant...
May 2018: Animal Reproduction Science
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