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https://www.readbyqxmd.com/read/28315120/prognostic-biomarkers-in-acute-coronary-syndromes-risk-stratification-beyond-cardiac-troponins
#1
REVIEW
K M Eggers, B Lindahl
PURPOSE OF REVIEW: Cardiac troponin (cTn) plays an essential role for assessment of outcome in acute coronary syndrome (ACS). However, the prognostic value of cTn is not absolute. In this mini-review, we summarize the evidence on the utility of established biomarkers of left-ventricular dysfunction, hemodynamic stress, inflammation, and renal dysfunction for risk prediction beyond cTn in ACS. RECENT FINDINGS: Only few biomarkers consistently demonstrate additive prognostic value to cTn levels...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28301573/panel-of-three-novel-serum-markers-predicts-liver-stiffness-and-fibrosis-stages-in-patients-with-chronic-liver-disease
#2
Marcin Krawczyk, Simone Zimmermann, Georg Hess, Robert Holz, Marc Dauer, Jochen Raedle, Frank Lammert, Frank Grünhage
Latest data suggest that placental growth factor (PLGF), growth differentiation factor-15 (GDF-15) and hepatic growth factor (HGF) are involved in hepatic fibrogenesis. Diagnostic performance of these markers for non-invasive liver fibrosis prediction was evaluated based on liver histology and stiffness. In total 834 patients were recruited. Receiver-operating-characteristics were used to define cut-offs for markers correlating to fibrosis stages. Odds-ratios were calculated for the presence/absence of fibrosis/cirrhosis and confirmed in the sub-group of patients phenotyped by elastography only...
2017: PloS One
https://www.readbyqxmd.com/read/28287848/immunomodulating-and-immunoresistance-properties-of-cancer-initiating-cells-implications-for-the-clinical-success-of-immunotherapy
#3
Cristina Maccalli, Giorgio Parmiani, Soldano Ferrone
Cancer-initiating cells (CICs) represent a relatively rare subpopulation of cells endowed with self-renewal, stemness properties, tumorigenicity in immunodeficient mice, and resistance to standard therapies as well as to immunotherapy. Here, we review the biological and immunological characteristics of CICs with special focus on the immunomodulating mechanisms they utilize to escape from immunosurveillance. The recently developed immunotherapeutic strategies have yielded remarkable clinical results in many types of tumors, indicating that indeed a patient's immune system can mount an immune response, which is effective in controlling tumor growth...
March 13, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28283847/increased-plasma-concentrations-of-soluble-st2-independently-predict-mortality-but-not-cardiovascular-events-in-stable-coronary-heart-disease-patients-13-year-follow-up-of-the-karola-study
#4
Vanessa Pfetsch, Veronika Sanin, Andrea Jaensch, Dhayana Dallmeier, Ute Mons, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
PURPOSE: sST2 (soluble suppression of tumorigenicity 2), a member of the interleukin-1 family, has been suggested to play a role in cardiac remodeling and inflammatory signaling. We assessed the association between sST2 in patients with stable coronary heart disease (CHD) with multiple cardiovascular outcomes and total mortality, simultaneously controlling for a large number of potential confounders. METHODS: Plasma concentrations of sST2 (ELISA, Critical Diagnostics) were measured at baseline in a cohort of 1081 patients...
March 10, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28270449/supraphysiological-levels-of-gdf11-induce-striated-muscle-atrophy
#5
David W Hammers, Melissa Merscham-Banda, Jennifer Ying Hsiao, Stefan Engst, James J Hartman, H Lee Sweeney
Growth and differentiation factor (GDF) 11 is a member of the transforming growth factor β superfamily recently identified as a potential therapeutic for age-related cardiac and skeletal muscle decrements, despite high homology to myostatin (Mstn), a potent negative regulator of muscle mass. Though several reports have refuted these data, the in vivo effects of GDF11 on skeletal muscle mass have not been addressed. Using in vitro myoblast culture assays, we first demonstrate that GDF11 and Mstn have similar activities/potencies on activating p-SMAD2/3 and induce comparable levels of differentiated myotube atrophy...
March 7, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28245821/gdf-15-plasma-levels-in-chronic-obstructive-pulmonary-disease-are-associated-with-subclinical-coronary-artery-disease
#6
Carlos H Martinez, Christine M Freeman, Joshua D Nelson, Susan Murray, Xin Wang, Matthew J Budoff, Mark T Dransfield, John E Hokanson, Ella A Kazerooni, Gregory L Kinney, Elizabeth A Regan, J Michael Wells, Fernando J Martinez, MeiLan K Han, Jeffrey L Curtis
BACKGROUND: Growth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unknown. We tested associations between GDF-15 and subclinical coronary atherosclerosis, assessed by coronary artery calcium (CAC) score, in COPD subjects free of clinical cardiovascular disease (CVD). METHODS: Cross-sectional analysis of COPD participants (GOLD stages 2-4) in the COPDGene cohort without CVD at enrollment, using baseline CAC (from non-EKG-gated chest computed tomography) and plasma GDF-15 (by custom ELISA)...
February 28, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28223232/the-versatility-and-paradox-of-gdf-11
#7
REVIEW
A Jamaiyar, W Wan, D M Janota, M K Enrick, W M Chilian, L Yin
In addition to its roles in embryonic development, Growth and Differentiation Factor 11 (GDF 11) has recently drawn much interest about its roles in other processes, such as aging. GDF 11 has been shown to play pivotal roles in the rescue of the proliferative and regenerative capabilities of skeletal muscle, neural stem cells and cardiomyocytes. We would be remiss not to point that some controversy exists regarding the role of GDF 11 in biological processes and whether it will serve as a therapeutic agent. The latest studies have shown that the level of circulating GDF 11 correlates with the outcomes of patients with cardiovascular diseases, cancer and uremia...
February 14, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28217814/-effects-of-growth-differentiation-factor-15-gdf-15-on-neurological-systems-cardiovascular-diseases-and-cancer-progression
#8
Dong-Dong Liu, Yan-Ai Mei
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. It has been suggested that GDF-15 has neurotropic effects in the nervous system. Our studies showed that GDF-15 modulated the expression of neuronal K(+) and Ca(2+) ion channels and increased the release of excitatory transmitter in the medial prefrontal cortex of mice...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28212715/novel-biomarkers-of-heart-failure
#9
A Savic-Radojevic, M Pljesa-Ercegovac, M Matic, D Simic, S Radovanovic, T Simic
Although substantial improvements have been made in majority of cardiac disorders, heart failure (HF) remains a major health problem, with both increasing incidence and prevalence over the past decades. For that reason, the number of potential biomarkers that could contribute to diagnosis and treatment of HF patients is, almost exponentially, increasing over the recent years. The biomarkers that are, at the moment, more or less ready for use in everyday clinical practice, reflect different pathophysiological processes present in HF...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28206960/an-autocrine-paracrine-circuit-of-growth-differentiation-factor-gdf-15-has-a-role-for-maintenance-of-breast-cancer-stem-like-cells
#10
Asako Sasahara, Kana Tominaga, Tatsunori Nishimura, Masao Yano, Etsuko Kiyokawa, Miki Noguchi, Masakuni Noguchi, Hajime Kanauchi, Toshihisa Ogawa, Hiroshi Minato, Keiichiro Tada, Yasuyuki Seto, Arinobu Tojo, Noriko Gotoh
Cancer stem cells are thought to be responsible for tumor growth, recurrence, and resistance to conventional cancer therapy. However, it is still unclear how they are maintained in tumor tissues. Here, we show that the growth differentiation factor 15 (GDF15), a member of the TGFβ family, may maintain cancer stem-like cells in breast cancer tissues by inducing its own expression in an autocrine/paracrine manner. We found that GDF15, but not TGFβ, increased tumor sphere formation in several breast cancer cell lines and patient-derived primary breast cancer cells...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28202998/-comparative-study-of-proliferative-and-periodontal-differentiation-propensity-of-induced-pluripotent-stem-cells-at-different-passages
#11
J W Li, X H Yin, Q X Luan
OBJECTIVE: To compare the proliferative and periodontal specific differentiation abilities of induced pluripotent stem cells (iPSCs) at different passages, and to investigate whether long term culturing would have a negative influence on their proliferation and specific differentiation capacity, thus providing a theoretical basis for further in-depth research on periodontal regeneration and the possible clinical applications of iPSCs. METHODS: IPSCs derived from human gingival fibroblasts at passages 5, 10, 15 and 20 were recovered and cultured in vitro...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28185024/disturbed-iron-metabolism-in-erythropoietic-protoporphyria-and-association-of-gdf15-and-gender-with-disease-severity
#12
Jasmin Barman-Aksoezen, Domenico Girelli, Caterina Aurizi, Xiaoye Schneider-Yin, Natascia Campostrini, Luca Barbieri, Elisabeth I Minder, Gianfranco Biolcati
Patients with erythropoietic protoporphyria (EPP) have reduced activity of the enzyme ferrochelatase that catalyzes the insertion of iron into protoporphyrin IX (PPIX) to form heme. As the result of ferrochelatase deficiency, PPIX accumulates and causes severe photosensitivity. Among different patients, the concentration of PPIX varies considerably. In addition to photosensitivity, patients frequently exhibit low serum iron and a microcytic hypochromic anemia. The aims of this study were to (1) search for factors related to PPIX concentration in EPP, and (2) characterize anemia in EPP, i...
February 9, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28178959/il-8-predicts-early-mortality-in-patients-with-acute-hypercapnic-respiratory-failure-treated-with-noninvasive-positive-pressure-ventilation
#13
Brynja Jónsdóttir, Åsa Jaworowski, Carmen San Miguel, Olle Melander
BACKGROUND: Patients with Acute Hypercapnic Respiratory Failure (AHRF) who are unresponsive to appropriate medical treatment, are often treated with Noninvasive Positive Pressure Ventilation (NPPV). Clinical predictors of the outcome of this treatment are scarce. Therefore, we evaluated the role of the biomarkers IL-8 and GDF-15 in predicting 28-day mortality in patients with AHRF who receive treatment with NPPV. METHODS: The study population were 46 patients treated with NPPV for AHRF...
February 8, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28159780/growth-differentiation-factor-15-and-risk-of-ckd-progression
#14
Viji Nair, Cassianne Robinson-Cohen, Michelle R Smith, Keith A Bellovich, Zeenat Yousuf Bhat, Maria Bobadilla, Frank Brosius, Ian H de Boer, Laurent Essioux, Ivan Formentini, Crystal A Gadegbeku, Debbie Gipson, Jennifer Hawkins, Jonathan Himmelfarb, Bryan Kestenbaum, Matthias Kretzler, Maria Chiara Magnone, Kalyani Perumal, Susan Steigerwalt, Wenjun Ju, Nisha Bansal
Growth differentiation factor-15 (GDF-15) is a member of the TGF-β cytokine superfamily that is widely expressed and may be induced in response to tissue injury. Elevations in GDF-15 may identify a novel pathway involved in loss of kidney function among patients with CKD. Among participants in the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS), we tested whether kidney tissue expression of GDF15 mRNA correlates with circulating levels of GDF-15 and whether elevations in circulating GDF-15 are associated with decline in kidney function...
February 3, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28145442/elevated-gdf-15-contributes-to-pulmonary-inflammation-upon-cigarette-smoke-exposure
#15
F M Verhamme, L J M Seys, E G De Smet, S Provoost, W Janssens, D Elewaut, G F Joos, G G Brusselle, K R Bracke
The molecular mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD) are still unclear, however signaling pathways associated with lung development, such as the transforming growth factor (TGF)-β superfamily, could be implicated in COPD. Growth differentiation factor (GDF)-15, a member of the TGF-β superfamily, is involved in inflammation, mucus secretion, and cachexia. We analyzed the pulmonary expression of GDF-15 in smokers and patients with COPD, in cigarette smoke (CS)-exposed cultures of primary human bronchial epithelial cells (pHBECs), and in CS-exposed mice...
February 1, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28133908/a-multimarker-multi-time-point-based-risk-stratification-strategy-in-acute-heart-failure-results-from-the-relax-ahf-trial
#16
Biniyam G Demissei, Gad Cotter, Margaret F Prescott, G Michael Felker, Gerasimos Filippatos, Barry H Greenberg, Peter S Pang, Piotr Ponikowski, Thomas M Severin, Yi Wang, Min Qian, John R Teerlink, Marco Metra, Beth A Davison, Adriaan A Voors
AIMS: We evaluated the added prognostic value of a multi-time point-based multimarker panel of biomarkers in patients with acute heart failure (AHF). METHODS AND RESULTS: Seven circulating biomarkers [NT-proBNP, high sensitivity cardiac troponin T (hs-cTnT), soluble ST2 (sST2), growth differentiation factor 15 (GDF-15), cystatin-C, galectin-3, and high sensitivity C-reactive protein (hs-CRP)] were measured at baseline and on days 2, 5, 14, and 60 in 1161 patients enrolled in the RELAX-AHF trial...
January 30, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28124978/surface-modification-of-titanium-with-bmp-2-gdf-5-by-a-heparin-linker-and-its-efficacy-as-a-dental-implant
#17
Dae Hyeok Yang, Sang Woong Moon, Deok-Won Lee
In this study, we prepared human bone morphogenetic protein-2 (hBMP-2)/human growth and differentiation factor-5 (hGDF-5)-coated titanium (Ti) disc and screw types for controlled release of the growth factors (GFs). The two growth factors were coated onto Ti with a smooth surface using their specific interaction with heparin, because they have heparin binding sites in their molecular structures. Efficacy of the two growth factor-coated Ti for enhancement of bone formation and osseointegration was compared to pristine Ti, and hBMP-2- and hGDF-5-coated Ti in vivo...
January 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28110258/il1rl1-single-nucleotide-polymorphism-predicts-sst2-level-and-mortality-in-coronary-and-peripheral-artery-disease
#18
Jeng-Feng Lin, Semon Wu, Jyh-Ming Jimmy Juang, Fu-Tien Chiang, Lung-An Hsu, Ming-Sheng Teng, Shih-Tsung Cheng, Hsuan-Li Huang, Yu-Chen Sun, Pei-Yu Liu, Yu-Lin Ko
BACKGROUND AND AIMS: There are many IL1RL1 single nucleotide polymorphisms (SNP) significantly associated with circulating sST2 concentration. Little is known about the effects of IL1RL1 SNP on the outcome of cardiovascular disease. The aim of this study is to investigate whether IL1RL1 SNP can predict mortality. METHODS: We enrolled 601 individuals receiving health examination, 532 patients with coronary artery disease (CAD), and 86 patients with peripheral artery disease (PAD)...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28062617/growth-differentiation-factor-15-as-a-biomarker-in-cardiovascular-disease
#19
REVIEW
Kai C Wollert, Tibor Kempf, Lars Wallentin
BACKGROUND: Growth differentiation factor 15 (GDF-15) is expressed and secreted in response to inflammation, oxidative stress, hypoxia, telomere erosion, and oncogene activation. Cardiovascular (CV) disease is a major driver of GDF-15 production. GDF-15 has favorable preanalytic characteristics and can be measured in serum and plasma by immunoassay. CONTENT: In community-dwelling individuals higher concentrations of GDF-15 are associated with increased risks of developing CV disease, chronic kidney disease, and cancer, independent of traditional CV risk factors, renal function, and other biomarkers (C-reactive protein, B-type natriuretic peptide, cardiac troponin)...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28004184/midregional-proadrenomedullin-and-growth-differentiation-factor-15-are-not-influenced-by-obesity-in-heart-failure-patients
#20
Christoph Sinning, Francisco Ojeda, Philipp S Wild, Renate B Schnabel, Michael Schwarzl, Sevenai Ohdah, Karl J Lackner, Norbert Pfeiffer, Matthias Michal, Maria Blettner, Thomas Munzel, Tibor Kempf, Kai C Wollert, Kari Kuulasmaa, Stefan Blankenberg, Veikko Salomaa, Dirk Westermann, Tanja Zeller
BACKGROUND: Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. METHODS: Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/m(2)) and 107 individuals with HF...
December 21, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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