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https://www.readbyqxmd.com/read/28550241/acute-effects-of-moderate-altitude-on-biomarkers-of-cardiovascular-inflammation-and-endothelial-function-and-their-differential-modulation-by-dual-endothelin-receptor-blockade
#1
Michael Lichtenauer, Bjoern Goebel, Vera Paar, Bernhard Wernly, Thomas Gecks, Ilonka Rohm, Martin Förster, Stefan Betge, Hans R Figulla, Uta C Hoppe, Malte Kelm, Marcus Franz, Christian Jung
BACKGROUND: Endothelial dysfunction is accompanied by the release of microparticles (MP). OBJECTIVE: We sought to investigate the effect of moderate hypoxia on circulatory levels of microparticles, biomarkers of cardiovascular function and inflammation and on echocardiographic parameters in healthy volunteers staying at an altitude of 2978 m. METHODS: Eighteen healthy volunteers were subjected to moderate hypoxia by staying at 2978 m above sea level for three days...
May 24, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28548630/tenogenic-differentiation-of-human-embryonic-stem-cells
#2
Tina P Dale, Shazia Mazher, William R Webb, Jing Zhou, Nicola Maffulli, G-Q Chen, Alicia J El Haj, Nicholas R Forsyth
Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide alternative healing strategies. We sought to determine whether human embryonic stem cells (hESC) could be induced to differentiate into tendon-like cells by the addition of exogenous bone morphogenetic protein (BMP)12 (growth differentiation factor(GDF)7) and BMP13 (GDF6). hESC (SHEF-1) were maintained with or without BMP12/13 supplementation, or supplemented with BMP12/13 and the SMAD signalling cascade blocking agent, dorsomorphin...
May 26, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28526273/the-association-of-growth-differentiation-factor-15-gene-polymorphisms-with-growth-differentiation-factor-15-serum-levels-and-risk-of-ischemic-stroke
#3
Yang Xiang, Ting Zhang, Jing Guo, You-Fan Peng, Ye-Sheng Wei
BACKGROUND: Current evidence shows that growth differentiation factor-15 (GDF-15) plays an important role in the progression of ischemic stroke (IS). The aim of this study was to investigate the association between 3 single-nucleotide polymorphisms of the GDF-15 gene and IS susceptibility in the Chinese population. MATERIALS AND METHODS: The study subjects comprised 601 Chinese individuals, including 298 stroke patients and 303 age- and gender-matched healthy controls...
May 16, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28508818/biosignals-standards-and-fhir-the-way-to-go
#4
Stefan Sauermann, Veronika David, Alois Schlögl, Reinhard Egelkraut, Matthias Frohner, Birgit Pohn, Philipp Urbauer, Alexander Mense
BACKGROUND: Standards have become available to share semantically encoded vital parameters from medical devices, as required for example by personal healthcare records. Standardised sharing of biosignal data largely remains open. OBJECTIVES: The goal of this work is to explore available biosignal file format and data exchange standards and profiles, and to conceptualise end-to-end solutions. METHODS: The authors reviewed and discussed available biosignal file format standards with other members of international standards development organisations (SDOs)...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28506172/the-effect-of-myostatin-gdf-8-on-proliferation-and-tenocyte-differentiation-of-rat-bone-marrow-derived-mesenchymal-stem-cells
#5
Wei Le, Jeffrey Yao
BACKGROUND: The future in flexor tendon surgery involves tissue engineering approaches directed toward increasing early repair strength to accelerate tendon healing and to allow for earlier onset of rehabilitation. Previous work has shown that pluripotential mesenchymal stem cells may be successfully delivered to a tendon repair site using a suture carrier. The current work describes the use of Myostatin (GDF-8) to help guide these delivered pluripotential stem cells to differentiate down a tenocyte lineage to potentially maximize the reparative effects of these cells at the tendon repair site...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28494447/stromal-growth-differentiation-factor-15-and-its-association-with-ovarian-cancer
#6
Cid A Lima, Millena P Jammal, Agrimaldo Martins-Filho, Thales Parenti Silveira, Douglas C Micheli, Beatriz M Tavares-Murta, Eddie F C Murta, Rosekeila Simões Nomelini
BACKGROUND/AIMS: Growth differentiation factor 15 (GDF-15) is induced by pro-inflammatory cytokines. Higher levels of GDF-15 have been associated with malignancy. The aim of the study was to evaluate both tissue and serum levels of GDF-15 in ovarian neoplasms. METHODS: A cohort study evaluated 31 patients with benign ovarian tumors and 34 patients with ovarian cancer were evaluated in 2 years. The inclusion criterion was histopathological diagnosis of ovarian epithelial neoplasia...
May 12, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28486916/are-markers-of-cardiac-dysfunction-useful-in-the-assessment-of-cardiovascular-risk-in-dialysis-patients
#7
Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Maciej Banach, Jacek Rysz
Cardiovascular morbidity and mortality of dialysis patients is a major problem in this group. The purpose of this study was also to evaluate whether any of studied markers are better than troponin in early detection of the occurrence of ventricular arrhythmias and prolongation of QT interval. This study included 45 patients undergoing haemodialysis. ECG Holter and echocardiographic examination were performed before and after dialysis. The concentration of markers: copeptin, GDF-15, HFABP and troponin were measured with the use of ELISA tests...
May 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28486664/microrna-21-plays-a-pivotal-role-in-the-oocyte-secreted-factor-induced-suppression-of-cumulus-cell-apoptosis%C3%A2
#8
Xiao Han, Rui Xue, Hong-Jie Yuan, Tian-Yang Wang, Juan Lin, Jie Zhang, Bo Liang, Jing-He Tan
It is known that oocytes and cumulus cells (CCs) are more resistant to apoptosis than other compartments of the antral follicle. However, although oocyte-secreted factors (OSFs) have been found to be involved in suppressing bovine CC apoptosis, little is known about the intra-cellular mechanisms by which OSFs render CCs resistant to apoptosis. Here we show that coculture with mouse or pig cumulus-denuded oocytes, culture with recombinant mouse growth differentiation factor-9 (GDF-9) or culture in pig oocyte-conditioned medium (POCM) significantly inhibited CC apoptosis of mouse oocytectomized cumulus oophorus complexes (OOXs)...
May 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28458020/signaling-by-growth-differentiation-factor-5-through-the-bone-morphogenetic-protein-receptor-type-ib-protects-neurons-against-kainic-acid-induced-neurodegeneration
#9
Yuanzheng Zhao, Min Zhang, Hengfang Liu, Jianping Wang
Growth/differentiation factor-5 (GDF-5), a member of the transforming growth factor-beta (TGF-β) superfamily, has been shown to protect rat dopaminergic neurons against insult both in embryonic neuronal culture and in Parkinson's disease models. However, whether GDF-5 exerts neuroprotective effects in hippocampal neurons is unclear. Here, we show that both mRNA levels and protein levels of GDF-5 are decreased in the mouse hippocampus upon kainic acid (KA) treatment. KA induced dramatic neuronal loss specifically in the cornu ammonis 1 (CA1) and CA3 areas of the mouse hippocampus, while intracerebral infusion of GDF-5 prevented this neuronal loss...
April 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28453865/saliva-and-plasma-levels-of-cardiac-related-biomarkers-in-post-myocardial-infarction-patients
#10
N Rathnayake, K Buhlin, B Kjellström, B Klinge, C Löwbeer, A Norhammar, L Rydén, T Sorsa, T Tervahartiala, A Gustafsson
AIM: To relate cardiac biomarkers, such as Cystatin C and Growth differentiation factor-15 (GDF-15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. MATERIALS AND METHODS: 200 patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28440431/gdf-15-gene-expression-alterations-in-human-lymphoblastoid-cells-and-peripheral-blood-lymphocytes-following-exposure-to-ionizing-radiation
#11
Shuang Li, Qing-Zhao Zhang, De-Qin Zhang, Jiang-Bin Feng, Qun Luo, Xue Lu, Xin-Ru Wang, Kun-Peng Li, De-Qing Chen, Xiao-Feng Mu, Ling Gao, Qing-Jie Liu
The identification of rapid, sensitive and high‑throughput biomarkers is imperative in order to identify individuals harmed by radiation accidents, and accurately evaluate the absorbed doses of radiation. DNA microarrays have previously been used to evaluate the alterations in growth/differentiation factor 15 (GDF15) gene expression in AHH‑1 human lymphoblastoid cells, following exposure to γ‑rays. The present study aimed to characterize the relationship between the dose of ionizing radiation and the produced effects in GDF‑15 gene expression in AHH‑1 cells and human peripheral blood lymphocytes (HPBLs)...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28430124/association-between-serum-selenium-concentrations-and-levels-of-proinflammatory-and-profibrotic-cytokines-interleukin-6-and-growth-differentiation-factor-15-in-patients-with-alcoholic-liver-cirrhosis
#12
Andrzej Prystupa, Paweł Kiciński, Dorota Luchowska-Kocot, Anna Błażewicz, Jarosław Niedziałek, Grzegorz Mizerski, Mariusz Jojczuk, Andrzej Ochal, Jarosław J Sak, Wojciech Załuska
According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines-interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria...
April 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28426571/growth-differentiation-factor-5-accelerates-wound-closure-and-improves-skin-quality-during-repair-of-full-thickness-skin-defects
#13
Jennifer L Schiefer, Manuel Held, Paul C Fuchs, Erhan Demir, Frank Plöger, Hans-Eberhard Schaller, Afshin Rahmanian-Schwarz
BACKGROUND: A fast and stable wound closure is important, especially for extended and unstable wounds found after burn injuries. Growth can regulate a variety of cellular processes, including those involved in wound healing. Growth differentiation factor 5 (GDF-5) can accelerate fibroblast cell migration, cell proliferation, and collagen synthesis, which are essential for wound healing. Nevertheless, no standardized evaluation of the effect of GDF-5 on the healing of full-thickness wounds has been published to date...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28411246/growth-differentiation-factor-15-at-1%C3%A2-month-after-an-acute-coronary-syndrome-is-associated-with-increased-risk-of-major-bleeding
#14
Daniel Lindholm, Emil Hagström, Stefan K James, Richard C Becker, Christopher P Cannon, Anders Himmelmann, Hugo A Katus, Gerald Maurer, José Luis López-Sendón, Philippe Gabriel Steg, Robert F Storey, Agneta Siegbahn, Lars Wallentin
BACKGROUND: Growth differentiation factor-15 (GDF-15) is related to major bleeding when measured at initial presentation in patients with acute coronary syndromes (ACSs) treated with dual antiplatelet therapy. It is unknown whether follow-up measurements provide additional information. The objective of this study was to investigate whether GDF-15 measured 1 month after an ACS provides additional information beyond the baseline levels with regard to the risk of major bleeding. METHODS AND RESULTS: GDF-15 was measured at baseline and at 1 month after an ACS in 4049 patients included in the PLATelet inhibition and patient Outcomes (PLATO) trial...
April 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28389123/circulating-gdf-15-levels-predict-future-secondary-manifestations-of-cardiovascular-disease-explicitly-in-women-but-not-men-with-atherosclerosis
#15
Aisha Gohar, Isabel Gonçalves, Joyce Vrijenhoek, Saskia Haitjema, Ian van Koeverden, Jan Nilsson, Gert J de Borst, Jean-Paul de Vries, Gerard Pasterkamp, Hester M den Ruijter, Harry Björkbacka, Saskia C A de Jager
BACKGROUND: Elevated serum levels of growth differentiation factor-15 (GDF-15), is an established risk factor for a range of cardiovascular diseases. We aimed to evaluate the predictive value of plasma GDF-15 as a biomarker for secondary cardiovascular events (CVE) in patients with atherosclerosis undergoing carotid endarterectomy (CEA). Secondly, we determined whether plasma GDF-15 was associated with carotid plaque characteristics. METHODS: Circulating GDF-15 levels were determined by Luminex assay in a cohort of 1056 patients from the Athero-Express biobank...
March 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28385068/transforming-growth-factor-15-increased-in-severe-aplastic-anemia-patients
#16
Yuanyuan Shao, Honglei Wang, Chunyan Liu, Qiuying Cao, Rong Fu, Huaquan Wang, Ting Wang, Weiwei Qi, Zonghong Shao
OBJECTIVES: The patients with severe aplastic anemia (SAA) usually rely on red cell transfusion which lead to secondary iron overload. Transforming growth differentiation factor-15 (GDF-15) plays an important role in erythropoiesis and iron regulation. In this study, we investigated the level of GDF-15 and other indexes of iron metabolism in SAA patients to explore the correlation with GDF-15 and iron overload in SAA. METHODS: The levels of serum GDF-15, hepcidin (Hepc), and erythropoietin (EPO) were determined by ELISA...
April 6, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28367413/expression-of-folliculogenesis-related-genes-in-vitrified-human-ovarian-tissue-after-two-weeks-in-vitro-culture
#17
Zahra Shams Mofarahe, Mojdeh Salehnia, Marefat Ghaffari Novin, Nassim Ghorbanmehr, Mohammad Gholami Fesharaki
OBJECTIVE: This study was designed to evaluate the effects of vitrification and in vitro culture of human ovarian tissue on the expression of oocytic and follicular cell-related genes. MATERIALS AND METHODS: In this experimental study, ovarian tissue samples were obtained from eight transsexual women. Samples were cut into small fragments and were then assigned to vitrified and non-vitrified groups. In each group, some tissue fragments were divided into un-cultured and cultured (in α-MEM medium for 2 weeks) subgroups...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28359091/bmp15-mutations-associated-with-primary-ovarian-insufficiency-reduce-expression-activity-or-synergy-with-gdf9
#18
Liliana C Patiño, Kelly L Walton, Thomas D Mueller, Katharine E Johnson, William Stocker, Dulama Richani, David Agapiou, Robert B Gilchrist, Paul Laissue, Craig A Harrison
Context: Bone morphogenetic protein (BMP)15 is an oocyte-specific growth factor, which, together with growth differentiation factor (GDF) 9, regulates folliculogenesis and ovulation rate. Multiple mutations in BMP15 have been identified in women with primary ovarian insufficiency (POI), supporting a pathogenic role; however, the underlying biological mechanism of many of these mutants remains unresolved. Objectives: To determine how mutations associated with ovarian dysfunction alter the biological activity of human BMP15...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28346732/asiaticoside-hinders-the-invasive-growth-of-keloid-fibroblasts-through-inhibition-of-the-gdf-9-mapk-smad-pathway
#19
Xin Wu, Difei Bian, Yannong Dou, Zhunan Gong, Qian Tan, Yufeng Xia, Yue Dai
Higher expression of growth differentiation factor-9 (GDF-9) in keloids compared with hypertrophic scars and normal skin tissues has been reported recently. The present study was performed to investigate the role of GDF-9 in keloid pathogenesis, and to elucidate its implication for asiaticoside in the keloid management. The data showed that GDF-9 could enhance the proliferation, migration, and invasion of keloid fibroblasts (KFs), while it only slightly elevated collagen expression, indicating that the effect of GDF-9 was opposite to that of TGF-β1...
March 27, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28341782/predictive-properties-of-biomarkers-gdf-15-ntprobnp-and-hs-tnt-on-morbidity-and-mortality-in-type-2-diabetes-patients-with-nephropathy
#20
Arash Bidadkosh, Sebastiaan P H Lambooy, Hiddo J Heerspink, Michelle J Pena, Robert H Henning, Hendrik Buikema, Leo E Deelman
OBJECTIVE: Although type 2 diabetes (T2D) patients with nephropathy are at high risk for renal and cardiovascular complications, relevant biomarkers have been poorly identified. Because renal impairment may increase biomarker levels, this potentially confounds associations between biomarker levels and risk. To investigate the predictive value of a biomarker in such a setting, we examined baseline levels of growth differentiation factor-15 (GDF-15), N-terminal prohormone of B-type natriuretic peptide (NTproBNP), and high-sensitivity troponin-T (hs-TnT) in relation to renal and cardiovascular risk in T2D patients with nephropathy...
March 24, 2017: Diabetes Care
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