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Immunocompromised surgery

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https://www.readbyqxmd.com/read/29319040/refractory-bronchovascular-pleuropulmonary-mucormycosis-case-report-and-difficulties-in-management
#1
M Manjunath, Deepak Prajapat, Rahul Kumar Sharma, Deepak Talwar
Pulmonary mucormycosis is a life-threatening opportunistic fungal infection. It is considered as a disease of immunocompromised state and is rarely seen in immunocompetent patients. We here report a case of refractory bronchovascular pleuropulmonary mucormycosis, who despite early detection, optimal management with liposomal amphotericin B, and posaconazole therapy followed by surgery, progressed further and led to a fatal outcome. Dual antifungal therapy combined with surgery is the only definitive treatment option available in the literature...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29299899/clinical-guidelines-for-the-antibiotic-treatment-for-community-acquired-skin-and-soft-tissue-infection
#2
Yee Gyung Kwak, Seong Ho Choi, Tark Kim, Seong Yeon Park, Soo Hong Seo, Min Bom Kim, Sang Ho Choi
Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. This clinical guideline provides recommendations for the diagnosis and management of SSTI, including impetigo/ecthyma, purulent skin and soft tissue infection, erysipelas and cellulitis, necrotizing fasciitis, pyomyositis, clostridial myonecrosis, and human/animal bite. This guideline targets community-acquired skin and soft tissue infection occurring among adult patients aged 16 years and older...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29285995/the-challenges-of-treating-aspergillus-abdominal-aneurysm-after-hematopoietic-cell-transplant-rapid-voriconazole-metabolizer
#3
Justin A Wasko, Celalettin Ustun, Mark Birkenbach, Rumi Faizer, Jaime S Green
Mycotic aneurysms are a fatal manifestation of disseminated fungal infections in immunocompromised hosts. We present a patient with an Aspergillus mycotic aneurysm after hematopoietic cell transplant. Due to CYP2C19 rapid metabolizer phenotype (*1/*17), therapeutic levels of voriconazole were unobtainable. Successful therapy was achieved with posaconazole salvage therapy and early, aggressive surgery. This case demonstrates the consequences of voriconazole rapid metabolism and the potential impact of genetic variants...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29283878/occupational-cns-aspergillosis-in-an-immunocompetent-individual-a-diagnostic-challange
#4
Parul Punia, Nidhi Goel, Ishwar Singh, Uma Chaudhary
INTRODUCTION: Immunocompetent individuals are rarely affected by Aspergillus species and its prime importance lies in immunocompromised patients where it can cause disease, ranging from primarily pulmonary infections to dissemination anywhere in the body. Invasive aspergillosis (IA) occurs in patients with risk factors including prolonged neutropenia, neutrophil dysfunction, patient on cytotoxic drugs, steroid therapy, hematological malignancy, AIDS or in patients with bone marrow transplantation...
December 28, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/29274090/case-of-femoral-pseudarthrosis-due-to-scedosporium-apiospermum-in-an-immunocompetent-patient-with-successful-conservative-treatment-and-review-of-literature
#5
Aurélien Dinh, Olivier Demay, Martin Rottman, Fabrice Gaudot, Marie-Elisabeth Bougnoux, Frédérique Bouchand, Hélène Coignard, Claire Rouzaud, Benjamin Davido, Clara Duran, Christophe Nich
Scedosporium apiospermum is a ubiquitous filamentous fungus, commonly found in soil, sewage, and polluted waters. It is rarely pathogenic but can cause a broad spectrum of clinical diseases, which can be localized or disseminate to distant organs. The disseminated form of the disease is mostly seen among immunocompromised patients. However, some rare cases of disseminated disease have been reported in immunocompetent individuals. Treatment of these infections is challenging because of their natural resistance to many antifungal agents...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29236649/deadly-sphenoid-fungus-isolated-sphenoid-invasive-fungal-rhinosinusitis-a-case-report
#6
Jason E Gilde, Christopher C Xiao, Victoria A Epstein, Jonathan Liang
INTRODUCTION: Acute invasive fungal rhinosinusitis (AIFRS) is a potentially fatal infection, usually affecting immunocompromised patients. Isolated sphenoid sinus involvement is rare and has been reported in only a few cases. We discuss the clinical characteristics, histopathologic features, and differential diagnosis of AIFRS of the sphenoid sinus. CASE PRESENTATION: A 57-year-old man with a history of refractory non-Hodgkin lymphoma and neutropenia presented with a 1-week duration of left-sided headache and ipsilateral cheek paresthesia...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29223631/nontuberculous-mycobacterial-infections-of-the-upper-extremity-15-year-experience-at-a-tertiary-care-medical-center
#7
David Sotello, Hillary W Garner, Michael G Heckman, Nancy N Diehl, Peter M Murray, Salvador Alvarez
PURPOSE: To present our experience with culture-positive, nontuberculous mycobacterial infections (NTMI) of the upper extremity and to compare the clinical features and outcomes of treatment among immunocompetent and immunocompromised patients. METHODS: All patients at our medical center diagnosed with NTMI of the upper extremity from December 1, 2000, through December 31, 2015, were included. We performed a retrospective analysis of patient demographic characteristics, delay to diagnosis, risk factors, clinical presentation, specific location, diagnostic testing, treatment regimens, and outcomes...
December 6, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29204303/maxillary-sinus-kaposi-sarcoma-case-report-in-an-hiv-negative-patient-with-thymoma
#8
Bernardo Carvalho Araújo, Sara Viana Baptista, Luís Mascarenhas, Ezequiel Barros
Introduction: Kaposi sarcoma is an angioproliferative disorder that requires infection with human herpesvirus 8 (HHV-8) for its development. The majority of cases are associated with HIV infection or other immunocompromising conditions. Thymomas are occasionally associated to cytopenia, which may alter the patients' immune responses. Methods: Case report using clinical records. Results: Case report of a 46-year-old male patient diagnosed with thymoma and myasthenia gravis...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29132552/intravenous-drug-abuse-is-a-risk-factor-in-the-failure-of-two-stage-treatment-for-infected-total-hip-arthroplasty
#9
Yu-Jie Su, Sung-Yen Lin, Hsuan-Ti Huang, Je-Ken Chang, Chung-Hwan Chen
Reinfection after two-stage revision hip arthroplasty (RHA) is still a complex issue. Only few studies revealed the factors affecting the success rate in the treatment of periprosthetic hip infection (PHI), especially risk factors. A retrospective study was conducted using records of 30 patients underwent two-stage RHA for infected total hip arthroplasty (THA). Treatment was defined as successful if a patient did not need any reoperation or invasive procedure such as image-guided drainage during the two years after reimplantation...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29125666/tenosynovitis-caused-by-mycobacterium-malmoense-in-two-kidney-transplant-recipients-and-review-of-the-literature
#10
Rebecca van Grootveld, Hans U Scherer, Elke E M Peters, André Gaasbeek, Sandra M Arend, Herman F Wunderink
We report two unrelated cases of tenosynovitis caused by Mycobacterium malmoense in kidney transplant recipients. Both patients received immunosuppression and were referred to our tertiary hospital because of persisting complaints lasting >6 months not responding to corticosteroids or surgery. The mycobacterial cultures were positive for the slow-growing M. malmoense after several weeks of incubation. The patient in Case 1 was treated with a combination of surgical debridement and antibiotics, whereas the patient in Case 2 was only treated surgically...
November 10, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29095293/-message-from-a-turtle-otitis-with-salmonella-arizonae-in-children-case-report
#11
Cristina Gavrilovici, Carmen-Valentina Pânzaru, Sebastian Cozma, Cristian Mârţu, Vasile Valeriu Lupu, Ancuta Ignat, Ingrith Miron, Magdalena Stârcea
RATIONALE: Salmonella enterica subsp arizonae is a common gut inhabitant of reptiles (snakes are the most common reservoir, but it also occurs in turtles). Alhough human cases owing to this organism are exceedingly rare, it may occasionally infect young infants and immunocompromised individuals with a history of intimate associations with reptiles. Our case is the 20th one among the infections with S arizonae in children, but the 2nd one of otitis and the first of mastoiditis. The other cases had different anatomical locations, such as gastroenteritis, osteomyelitis, meningitis, ankle infection, wound infection, and sinusitis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29068969/positive-effect-of-incubated-adipose-derived-mesenchymal-stem-cells-on-microfat-graft-survival
#12
Jong Woo Choi, Sung-Chan Kim, Eun-Jung Park, Ju-A Lee, Woo Shik Jeong
Autologous fat grafting is commonly used for soft tissue augmentation, but its unpredictably high resorption rate remains a major limitation. Although adipose-derived mesenchymal stem cells (ASCs) are an attractive candidate for enhancing graft retention, their poor posttransplantation viability limits their application. The authors aimed to evaluate the effect of incubated ASCs on microfat graft survival in an immunocompromised mouse model. Lipoaspirates for microfat injection were collected from the wasted lower abdominal adipose tissues of 5 patients who had undergone breast reconstructive surgery with an abdominal flap...
October 24, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29044057/clinicodemographic-profile-and-treatment-outcome-in-patients-of-ocular-surface-squamous-neoplasia
#13
Rachna Meel, Rebika Dhiman, Murugesan Vanathi, Neelam Pushker, Radhika Tandon, Saranya Devi
PURPOSE: The aim is to study the clinicodemographic profile and treatment outcome of ocular surface squamous neoplasia (OSSN). METHODS: This was a retrospective observational study of 57 eyes (56 cases) with clinically diagnosed OSSN, presenting in our center over the past year. RESULTS: The median age of presentation was 55 years with male:female ratio being 4.5:1. Systemic predisposing conditions were xeroderma pigmentosa (1) postkidney transplant immunosuppression (1), and human immunodeficiency virus infection (1)...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29016292/risk-factors-for-methicillin-resistant-staphylococcus-aureus-carriage-among-patients-at-admission-to-the-surgical-ward-in-a-resource-limited-hospital-in-indonesia
#14
Dewi Santosaningsih, Sanarto Santoso, Henri A Verbrugh, Juliëtte A Severin
This study aimed to identify risk factors for methicillin-resistant Staphylococcus aureus (MRSA) carriage among patients at admission to the surgery ward in a resource-limited hospital in Indonesia. A case-control study was performed including 65 MRSA carriage patients and 132 non-MRSA carriage patients screened at admission to surgery wards in a hospital in Malang, East Java. For MRSA screening, swabs were obtained from nares and throat, cultured in an enrichment broth followed by subculturing onto CHROMagar(™) MRSA; suspected colonies were confirmed by polymerase chain reaction...
September 18, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28990897/chronic-necrotizing-pulmonary-aspergillosis-in-an-immunocompetent-patient-after-the-surgery-of-hydatid-cyst
#15
Nagehan Emiralioğlu, Hatice Nursun Özcan, Diclehan Orhan, Mithat Haliloğlu, Ali Bülent Cengiz, Elmas Ebru Yalçın, Deniz Doğru Ersöz, Nural Kiper, Hayriye Uğur Özçelik
Chronic necrotizing pulmonary aspergillosis (CNPA) is a condition caused by the ubiquitous fungus Aspergillus fumigatus in non-immunocompromised individuals. Numerous underlying conditions have been associated with CNPA. Tuberculosis, non-tuberculous mycobacterial infection and allergic bronchopulmonary aspergillosis (ABPA) remain the predominant risk factors for development of CNPA. Development of CNPA in echinococcal cyst cavities is very rare and the optimal therapeutic regimen and treatment duration have not been established...
June 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28975983/hiv-patient-with-pseudomyxoma-peritonei-of-extra-appendiceal-origin-is-disease-free-and-alive-9-years-after-complete-cytoreductive-surgery
#16
A Tampakis, E C Tampaki, P Alexandrou, K Kontzoglou, G Kouraklis
OBJECTIVE: Pseudomyxoma peritonei (PMP) is a clinical syndrome that is mainly characterized by the presence of mucinous ascites that results from the rupture of a mucin-producing neoplasm. No reports exist so far regarding the management of this syndrome in HIV patients. CASE REPORT: A 54-year old male patient with a diagnosed atypical colitis developed additionally over time a complicated diverticulitis which was initially treated conservatively with antibiotics...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28930791/polydactylous-bowen-s-disease-in-an-immunocompromised-patient-resolution-of-all-lesions-after-mohs-surgery-on-a-single-lesion
#17
Nikita S Goel, Rajat Varma, Daniel C Zedek, Puneet S Jolly
No abstract text is available yet for this article.
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28924368/the-effects-of-perioperative-anesthesia-and-analgesia-on-immune-function-in-patients-undergoing-breast-cancer-resection-a-prospective-randomized-study
#18
Jin Sun Cho, Mi-Hyang Lee, Seung Il Kim, Seho Park, Hyung Seok Park, Ein Oh, Jong Ho Lee, Bon-Nyeo Koo
Introduction: Perioperative anesthesia and analgesia exacerbate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. We compared the effects of two different anesthesia and analgesia methods on the NK cell cytotoxicity (NKCC) in patients undergoing breast cancer surgery. Methods: Fifty patients undergoing breast cancer resection were randomly assigned to receive propofol-remifentanil anesthesia with postoperative ketorolac analgesia (Propofol-ketorolac groups) or sevoflurane-remifentanil anesthesia with postoperative fentanyl analgesia (Sevoflurane-fentanyl group)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28922488/isolation-of-rhodotorula-mucilaginosa-from-blood-cultures-in-a-tertiary-care-hospital
#19
Iker Falces-Romero, Emilio Cendejas-Bueno, María Pilar Romero-Gómez, Julio García-Rodríguez
Rhodotorula species have traditionally been considered as one of common non-virulent environmental inhabitant. They have emerged as an opportunistic pathogen, particularly in immunocompromised hosts and most infections have been associated with intravenous catheters in these patients. We review the isolates in blood cultures of Rhodotorula mucilaginosa in our Hospital. We describe the demographic and clinical features of the cases and the antifungal susceptibility profiles of the isolates. Selected patients had an isolation of R...
September 18, 2017: Mycoses
https://www.readbyqxmd.com/read/28831383/infective-endocarditis-caused-by-pseudomonas-stutzeri-in-a-patient-with-marfan-syndrome-case-report-and-brief-literature-review
#20
Ahmad Shalabi, Tristan Ehrlich, Hans-Joachim Schäfers, Sören L Becker
Invasive infections due to Pseudomonas stutzeri have rarely been described and mainly occur in immunocompromised individuals. We report a case of infective endocarditis caused by P. stutzeri after previous cardiac surgery in a Lebanese patient with Marfan syndrome. We review the literature and conclude that this pathogen may be of particular medical relevance in the Mediterranean Basin.
2017: IDCases
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