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https://www.readbyqxmd.com/read/29162668/huai-qi-huang-corrects-the-balance-of-th1-th2-and-treg-th17-in-an-ovalbumin-induced-asthma-mouse-model
#1
Peng Liang, Shao Peng, Man Zhang, Yingying Ma, Xinggang Zhen, Huijuan Li
This study is designed to determine whether Huai Qi Huang has immuno-regulatory effects on the Th1/Th2 and Treg/Th17 balance in ovalbumin (OVA)-induced asthma model mice. Asthma model mice were constructed by OVA treatment and Huai Qi Huang was administrated. The amount of migrated inflammatory cells in the bronchoalveolar lavage fluid (BALF) from the OVA mice was counted. The total immunoglobulin E (IgE) in the sera was detected by the IgE ELISA kit. Cell suspensions from the lung were stained with antibodies specific for CD4 and the master transcription factors for Th1 (T-bet), Th2 (Gata-3), Th17 (RORγt), and Treg (Foxp3)...
November 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29137548/exploring-organisational-competences-in-human-factors-and-ux-project-work-managing-careers-project-tactics-and-organisational-strategy
#2
Dominic Furniss, Paul Curzon, Ann Blandford
Organisational competence in Human Factors and UX (user experience) has not been looked at before despite its relevance to project success. We define organisational competence as the collective competence of the individuals, bringing together their complementary abilities to deliver an outcome that is typically more than the sum of its parts. Twenty-two UX and Human Factors practitioners were interviewed about their project work in two contrasting domains: web design and safety-critical systems to explore organisational competences...
November 15, 2017: Ergonomics
https://www.readbyqxmd.com/read/28955308/ar-13-a-celecoxib-derivative-directly-kills-francisella-in-vitro-and-aids-clearance-and-mouse-survival-in-vivo
#3
Ky V Hoang, Haley E Adcox, James R Fitch, David M Gordon, Heather M Curry, Larry S Schlesinger, Peter White, John S Gunn
Francisella tularensis (F. tularensis) is the causative agent of tularemia and is classified as a Tier 1 select agent. No licensed vaccine is currently available in the United States and treatment of tularemia is confined to few antibiotics. In this study, we demonstrate that AR-13, a derivative of the cyclooxygenase-2 inhibitor celecoxib, exhibits direct in vitro bactericidal killing activity against Francisella including a type A strain of F. tularensis (SchuS4) and the live vaccine strain (LVS), as well as toward the intracellular proliferation of LVS in macrophages, without causing significant host cell toxicity...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28931540/review-on-the-secret-life-of-ion-channels-kv1-3-potassium-channels-and-cell-proliferation
#4
M Teresa Perez Garcia, Pilar Cidad, Jose R Lopez-Lopez
Kv1.3 channels are involved in the switch to proliferation of normally quiescent cells, being implicated in the control of cell cycle in many different cell types and in many different ways. They modulate membrane potential controlling K(+) fluxes, sense changes in potential and interact with many signaling molecules through their intracellular domains. From a mechanistic point of view, we can describe the role of Kv1.3 channels in proliferation with at least three different models. In the "membrane potential model", membrane hyperpolarization resulting from Kv1...
September 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28883160/user-experience-evaluations-in-rehabilitation-video-games-for-children-a-systematic-mapping-of-the-literature
#5
Carolina Rico-Olarte, Diego M López, Bernd Blobel, Sara Kepplinger
BACKGROUND: In recent years, the interest in user experience (UX) evaluation methods for assessing technology solutions, especially in health systems for children with special needs like cognitive disabilities, has increased. OBJECTIVE: Conduct a systematic mapping study to provide an overview in the field of UX evaluations in rehabilitation video games for children. METHODS: The definition of research questions, the search for primary studies and the extraction of those studies by inclusion and exclusion criteria lead to the mapping of primary papers according to a classification scheme...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28881037/comparison-of-vessel-enhancement-algorithms-applied-to-time-of-flight-mra-images-for-cerebrovascular-segmentation
#6
Renzo Phellan, Nils D Forkert
PURPOSE: Vessel enhancement algorithms are often used as a preprocessing step for vessel segmentation in medical images to improve the overall segmentation accuracy. Each algorithm uses different characteristics to enhance vessels, such that the most suitable algorithm may vary for different applications. This paper presents a comparative analysis of the accuracy gains in vessel segmentation generated by the use of nine vessel enhancement algorithms: Multiscale vesselness using the formulas described by Erdt (MSE), Frangi (MSF), and Sato (MSS), optimally oriented flux (OOF), ranking orientations responses path operator (RORPO), the regularized Perona-Malik approach (RPM), vessel enhanced diffusion (VED), hybrid diffusion with continuous switch (HDCS), and the white top hat algorithm (WTH)...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28873798/inclusive-smartphone-interface-design-in-context-co-re-designing-the-pis
#7
Paul Magee, Gillian Ward, Louise Moody, Annette Roebuck
User-context optimises smartphone interface-design. Neglect of user-context during development, delays or prevents marginalised-consumer benefit. Working with People with Learning Disability (PWLD) to develop interfaces refined by communication-need will improve User-Experience (UX). In research, a Participant Information Sheet (PIS) discloses planned study-activity. This paper explains co-creation of a PIS based on communication-need of PWLD.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28816077/in-vitro-evaluation-of-the-occlusive-properties-of-the-artventive-endoluminal-occlusion-system-occlusion-device-for-transrenal-ureteral-occlusion
#8
Daniel Kuetting, Carsten Meyer, Hans Heinz Schild, Claus Christian Pieper
PURPOSE: Current techniques for percutaneous ureteral occlusion are either technically difficult or not satisfactory because of frequent ureteral recanalization. The purpose of this in vitro study was to evaluate the occlusive properties of an "off the shelf" solution (Endoluminal Occlusion System [EOS™]; ArtVentive Medical Group, Inc., Carlsbad, CA) for transrenal ureteral occlusion. MATERIALS AND METHODS: Both 8 and 11 mm expanded polytetrafluoroethylene-covered ArtVentive EOS devices were used in 10 porcine models...
October 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28802449/living-with-an-autonomous-spatiotemporal-home-heating-system-exploration-of-the-user-experiences-ux-through-a-longitudinal-technology-intervention-based-mixed-methods-approach
#9
Martin Kruusimagi, Sarah Sharples, Darren Robinson
Rising energy demands place pressure on domestic energy consumption, but savings can be delivered through home automation and engaging users with their heating and energy behaviours. The aim of this paper is to explore user experiences (UX) of living with an automated heating system regarding experiences of control, understanding of the system, emerging thermal behaviours, and interactions with the system as this area is not sufficiently researched in the existing homes setting through extended deployment. We present a longitudinal deployment of a quasi-autonomous spatiotemporal home heating system in three homes...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28649906/a-test-for-a-difference-in-the-associability-of-blocked-and-uninformative-cues-in-human-predictive-learning
#10
Metin Uengoer, Dominic M Dwyer, Stephan Koenig, John M Pearce
In human predictive learning, blocking, A+AB+, and a simple discrimination, UX+ VX-, result in a stronger response to the blocked, B, than the uninformative cue, X (where letters represent cues, and + and - represent different outcomes). In order to assess if these different treatments result in more attention being paid to blocked than uninformative cues, Stage 1 in each of three experiments generated two blocked cues, B and E, and two uninformative cues, X and Y. In Stage 2, participants received two simple discriminations: either BX+ EX- and BY+ EY-, or BX+ BY- and EX+ EY-...
June 25, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28535196/characterization-of-antixenosis-in-soybean-genotypes-to-bemisia-tabaci-hemiptera-aleyrodidae-biotype-b
#11
E L L Baldin, P L Cruz, R Morando, I F Silva, J P F Bentivenha, L R S Tozin, T M Rodrigues
Bemisia tabaci biotype B (Gennadius) is one of the most important soybean pest worldwide. Herein, 15 soybean genotypes were evaluated, to characterize the occurrence of antixenosis to B. tabaci biotype B. Initially, a multiple-choice test with all genotypes was carried out, evaluating the settling and oviposition preference at 3 d after infestation, and the colonization by nymphs after 48 d of infestation. Subsequently, a no-choice test, using 14 genotypes, was conducted with infested plants individually, and the number of eggs was counted after 72 h...
August 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28526667/patient-centered-decision-support-formative-usability-evaluation-of-integrated-clinical-decision-support-with-a-patient-decision-aid-for-minor-head-injury-in-the-emergency-department
#12
Edward R Melnick, Erik P Hess, George Guo, Maggie Breslin, Kevin Lopez, Anthony J Pavlo, Fuad Abujarad, Seth M Powsner, Lori A Post
BACKGROUND: The Canadian Computed Tomography (CT) Head Rule, a clinical decision rule designed to safely reduce imaging in minor head injury, has been rigorously validated and implemented, and yet expected decreases in CT were unsuccessful. Recent work has identified empathic care as a key component in decreasing CT overuse. Health information technology can hinder the clinician-patient relationship. Patient-centered decision tools to support the clinician-patient relationship are needed to promote evidence-based decisions...
May 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28490701/-adeabc-efflux-pump-and-resistance-of-acinetobacter-baumannii-against-carbapenem
#13
Qingya Dou, Mingxiang Zou, Jun Li, Haichen Wang, Yongmei Hu, Wen'en Liu
To investigate relationship between AdeABC efflux pump and resistance of Acinetobacter baumannii against carbapenem.
 Methods: Carbapenem-resistant strains were acquired from multistep selection resistance test by meropenem in vitro. The quantitation test for sensitivities of strains before and after induction was determined by the E-test, and carbonylcyanide-m-chlorophenylhydrazone (CCCP) inhibition test was used to screen efflux pump. PCR, sequencing analysis, or real-time PCR was used to analyze the changes of regulatory genes adeR and adeS of the AdeABC efflux pump system, or expressions of adeA, adeB, adeR, and adeS in the strains before and after induction, respectively...
April 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28464263/urised-3-and-ux-2000-automated-urine-sediment-analyzers-vs-manual-microscopic-method-a-comparative-performance-analysis
#14
Sathima Laiwejpithaya, Preechaya Wongkrajang, Kanit Reesukumal, Chonticha Bucha, Suriya Meepanya, Chanutchaya Pattanavin, Varanya Khejonnit, Achara Chuntarut
BACKGROUND: Fully automated urine analyzers now play an important role in routine urinalysis in most laboratories. The recently introduced UriSed 3 has a new automated digital imaging urine sediment analyzer with a phase contrast feature. The aim of this study was to compare the performance of the UriSed 3 and UX-2000 automated urine sediment analyzers with each other and with the results of the manual microscopic method. METHODS: Two hundred seventy-seven (277) samples of leftover fresh urine from our hospital's central laboratory were evaluated by two automated urine sediment analyzers-UriSed 3 and UX-2000...
May 2, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28440786/magnetic-and-transport-properties-of-a-layered-compound-ce2te5
#15
D Chen, S Zhang, H X Yang, J Q Li, G F Chen
Ce2Te5 single crystals were successfully grown using RbCl/LiCl flux method. The structure of Ce2Te5 can be viewed as a combination of CeTe2 and CeTe3. The experimental results of magnetic susceptibility [Formula: see text], isothermal magnetization M(H), electrical resistivity [Formula: see text], and heat capacity C(T) show two clear anomalies at 5.1 and 2.3 K, which correspond to a ferrimagnetic and a possible antiferromagnetic transition, respectively. Both of [Formula: see text] and C(T) confirm a third transition at 0...
July 5, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28296319/validation-of-the-calypso-surface-beacon-transponder
#16
Maxwell Belanger, Ziad Saleh, Tom Volpe, Rich Margiasso, Xiang Li, Maria Chan, Xiaofeng Zhu, Xiaoli Tang
Calypso L-shaped Surface Beacon transponder has recently become available for clinical applications. We herein conduct studies to validate the Surface Beacon transponder in terms of stability, reproducibility, orientation sensitivity, cycle rate dependence, and respiratory waveform tracking accuracy. The Surface Beacon was placed on a Quasar respiratory phantom and positioned at the isocenter with its two arms aligned with the lasers. Breathing waveforms were simulated, and the motion of the transponder was tracked...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28269687/stayfit-a-wearable-application-for-gym-based-power-training
#17
Maram Maheedhar, Aman Gaurav, Vivek Jilla, Vijay N Tiwari, Rangavittal Narayanan
Comprehensive fitness training involves both cardiorespiratory and power components. Often power/muscle strength training is confused with cardiorespiratory endurance training. However, each of them target different physiological aspects of fitness. Although, wearable based fitness trackers designed towards cardiorespiratory endurance training are available in the market, a dedicated wearable based fitness application designed for power training/tracking is still not readily available to fitness enthusiasts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28239338/differential-neural-responses-underlying-the-inhibition-of-the-startle-response-by-pre-pulses-or-gaps-in-mice
#18
Rocio Moreno-Paublete, Barbara Canlon, Christopher R Cederroth
Gap pre-pulse inhibition of the acoustic startle (GPIAS) is a behavioral paradigm used for inferring the presence of tinnitus in animal models as well as humans. In contrast to pre-pulse inhibition (PPI), the neural circuitry controlling GPIAS is poorly understood. To increase our knowledge on GPIAS, a comparative study with PPI was performed in mice combining these behavioral tests and c-Fos activity mapping in brain areas involved in the inhibition of the acoustic startle reflex (ASR). Both pre-pulses and gaps efficiently inhibited the ASR and abolished the induction of c-Fos in the pontine reticular nucleus...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28227948/stayfit-a-wearable-application-for-gym-based-power-training
#19
Maram Maheedhar, Aman Gaurav, Vivek Jilla, Vijay N Tiwari, Rangavittal Narayanan, Maram Maheedhar, Aman Gaurav, Vivek Jilla, Vijay N Tiwari, Rangavittal Narayanan, Rangavittal Narayanan, Vijay N Tiwari, Vivek Jilla, Aman Gaurav, Maram Maheedhar
Comprehensive fitness training involves both cardiorespiratory and power components. Often power/muscle strength training is confused with cardiorespiratory endurance training. However, each of them target different physiological aspects of fitness. Although, wearable based fitness trackers designed towards cardiorespiratory endurance training are available in the market, a dedicated wearable based fitness application designed for power training/tracking is still not readily available to fitness enthusiasts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28188739/comparison-of-automated-devices-ux-2000-and-sedimax-autionmax-for-urine-samples-screening-a-multicenter-spanish-study
#20
MULTICENTER STUDY
Catalina Sánchez-Mora, Delia Acevedo, Maria Amelia Porres, Ana María Chaqués, Javier Zapardiel, Aurelia Gallego-Cabrera, Jose María López, Jose María Maesa
OBJECTIVES: In this study we aim to compare UX2000 (Sysmex Corp, Japan) and SediMAX/AutionMax (Arkray Factory Inc., Japan), totally automatized analyzers, against Fuchs-Rosenthal counting chamber, the gold standard technique for sediment analysis. DESIGN AND METHODS: Urine samples of 1454 patients from three Spanish hospitals were assessed for red and white blood cells (RBC; WBC) using three different techniques: flow cytometry, image-based method and Fuchs-Rosenthal counting chamber...
August 2017: Clinical Biochemistry
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