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https://www.readbyqxmd.com/read/29222868/synthesis-of-a-new-microporous-zincosilicate-with-cha-zeolite-topology-as-efficient-platforms-for-ion-exchange-of-divalent-cations
#1
Natsume Koike, Kenta Iyoki, Sye Hoe Keoh, Watcharop Chaikittisilp, Tatsuya Okubo
There is growing interest to develop zeolite materials capable of stabilizing divalent cations such as Cu(II), Fe(II), and Ni(II) for catalytic applications. Herein, we describe for the first time the synthesis of a new microporous zincosilicate with CHA zeolite topology by particularly focusing on the mixing procedures of the raw materials to prevent the precipitation of zinc oxides/hydroxides and the formation of impure phases. The obtained zincosilicate CHA products possess remarkably higher ion-exchange ability for catalytically useful, divalent cations, demonstrated here using Ni(II) as an example, compared to that of aluminosilicate and zincoaluminosilicate analogs...
December 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29222690/risk-factor-of-contralateral-radiculopathy-following-microendoscopy-assisted-minimally-invasive-transforaminal-lumbar-interbody-fusion
#2
Yang Yang, Zhong-Yu Liu, Liang-Ming Zhang, Jian-Wen Dong, Pei-Gen Xie, Rui-Qiang Chen, Bu Yang, Chang Liu, Bin Liu, Li-Min Rong
PURPOSE: Microendoscopy-assisted minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is an advantageous method for treating lumbar degenerative disease; however, some patients show contralateral radiculopathy postoperatively. This study aims to investigate its risk factor. METHODS: A total of 130 cases who underwent microendoscopy-assisted MIS-TLIF at L4-5 level were divided into symptomatic and asymptomatic groups according to the presence of postoperative contralateral radiculopathy...
December 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29222131/low-dose-anthracycline-and-risk-of-heart-failure-in-a-pharmacokinetic-model-of-human-myocardium-exposure-analog-specificity-and-role-of-secondary-alcohol-metabolites
#3
Emanuela Salvatorelli, Pierantonio Menna, Massimo Chello, Elvio Covino, Giorgio Minotti
Cumulative doses of doxorubicin and other antitumor anthracyclines may cause heart failure (HF). Cardiotoxicity is determined by cardiac exposure to anthracyclines and to more toxic secondary alcohol metabolites that are formed inside cardiomyocytes or diffuse from the bloodstream. Concerns exist that HF might be caused by cumulative anthracycline doses that were thought to be safe. Patients with gain-of-function polymorphism of carbonyl reductase 3 (CBR3), which converts anthracyclines to secondary alcohol metabolites, would be at a higher risk of HF...
December 8, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29221844/gabapentin-as-an-adjuvant-therapy-for-prevention-of-acute-phantom-limb-pain-in-pediatric-patients-undergoing-amputation-for-malignant-bone-tumors-a-prospective-double-blind-randomized-controlled-trial
#4
Xiandi Wang, Ying Yi, Dingbo Tang, Yi Chen, Yanhua Jiang, Jun Peng, Jiwei Xiao
CONTEXT: Gabapentin is reported to have an analgesic effect of reducing phantom-limb pain(PLP) in adult patients. There's no study on preoperative use of gabapentin in pediatric population in term of PLP prevention. OBJECTIVE: To determine whether gabapentin could be used as an adjuvant agent of opioid-based pain control to lower the rate of phantom-limb pain in pediatric patients undergoing amputation for malignant bone tumors in observation period of 60 days post-operatively...
December 5, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29221837/a-single-center-retrospective-analysis-of-the-efficacy-of-a-new-balloon-catheter-in-autogenous-arteriovenous-fistula-dysfunction-resistant-to-conventional-balloon-angioplasty
#5
Xiaolei Sun, Yanzheng He, Yarong Ma, Huqiang He, Lei Zhang, Ivo Ricardo de Seabra Rodrigues Dias, Yong Liu
PURPOSE: To present a new alternative balloon catheter option for autogenous arteriovenous fistula (AVF) dysfunction with stiff constriction resistant to conventional balloon angioplasty. METHODS: Our first series of 51 patients with autogenous AVF dysfunction who were simultaneously treated with VascutrakTM balloon catheter, following failed conventional balloon therapy (failure was defined as residual stenosis of >30%), were retrospectively observed and analyzed...
December 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29221575/clinical-outcomes-of-suprascapular-nerve-decompression-a-systematic-review
#6
REVIEW
Amit M Momaya, Adam Kwapisz, W Stephen Choate, Michael J Kissenberth, Stefan J Tolan, Keith T Lonergan, Richard J Hawkins, John M Tokish
BACKGROUND: Suprascapular neuropathy is an uncommon clinical diagnosis. Although there have been a number of case series reporting on this pathologic process, to date there has been no systematic review of these studies. This study aimed to synthesize the literature on suprascapular neuropathy with regard to clinical outcomes. The secondary objective was to detail the diagnosis and treatment of suprascapular neuropathy and any associated complications. METHODS: A systematic review was performed to identify studies that reported the results or clinical outcomes of suprascapular nerve decompression...
January 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29221441/time-varying-serum-gradient-of-hepatitis-b-surface-antigen-predicts-risk-of-relapses-after-off-na-therapy
#7
Nai-Hsuan Chien, Yen-Tsung Huang, Chun-Ying Wu, Chi-Yang Chang, Ming-Shiang Wu, Jia-Horng Kao, Lein-Ray Mo, Chi-Ming Tai, Chih-Wen Lin, Tzeng-Huey Yang, Jaw-Town Lin, Yao-Chun Hsu
BACKGROUND: The serum gradient of hepatitis B surface antigen (HBsAg) varies over time after cessation of nucleos(t)ide analog (NA) treatment in patients with chronic hepatitis B (CHB). The association between the time-varying HBsAg serum gradient and risk of relapse has not been elucidated. METHODS: This multicenter cohort study prospectively enrolled CHB patients who discontinued 3 year-NA treatment. Eligible patients were serologically negative for HBeAg and viral DNA at NA cessation...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29221298/the-redax%C3%A2-coaxial-drain-in-pulmonary-lobectomy-a-study-of-efficacy
#8
Ottavio Rena, Sara Parini, Esther Papalia, Fabio Massera, Davide Turello, Guido Baietto, Caterina Casadio
Background: Pleural drainage is required after pulmonary lobectomy to evacuate air-leak and fluid. We compared the performance of the new Redax® Coaxial Drain (CD) (Redax, Mirandola, Italy) with a standard chest tube (CT) in terms of fluid and air-leak evacuation. Methods: Fifty-two patients receiving a 24-F CD under water-seal after pulmonary lobectomy through open surgery or video-assisted thoracic surgery (VATS) were matched according to demographic, clinical and pathological variables with 104 patients receiving a 24-F CT...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221267/the-acceptance-of-illness-the-intensity-of-pain-and-the-quality-of-life-in-patients-with-lung-cancer
#9
Mariusz Chabowski, Jacek Polański, Beata Jankowska-Polanska, Katarzyna Lomper, Dariusz Janczak, Joanna Rosinczuk
Background: Lung cancer is the major cause of cancer related deaths worldwide. The overall 5-year survival rate is very low and accounts for only 15%. Poor quality of life is considered a prognostic factor for shorter survival in lung cancer patients. The aim of the study was to examine the relationships between pain, the acceptance of illness and quality of life in patients with lung cancer. Methods: The study included 155 patients with lung cancer with mean age of 62...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220863/a-small-dose-of-apomorphine-counteracts-the-deleterious-effects-of-middle-cerebral-artery-occlusion-in-different-models
#10
F Mastroiacovo, A Gaglione, C L Busceti, L Ryskalin, G Bozza, F Nicoletti, F Orzi, F Fornai
The present manuscript investigates in two animal species by using two different experimental models of middle cerebral artery occlusion (permanent and transient), the neuroprotective effects of the dopamine receptor agonist apomorphine. These effects were evaluated by measuring the infarct volume and by counting muscle strength at different time points following the ischemic insult. Apomorphine at the dose of 3 mg/Kg when adminsitered at two hours following the occlusion of the middle cerebral artery was able to reduce significantly the infarct volume in the cortex of mice and the ischemic volume of the basal ganglia perfused by the perforant branches of the middle cerebral artery in the rat...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29220796/purine-analogs-targeting-the-guanine-riboswitch-as-potential-antibiotics-against-clostridioides-difficile
#11
Lok-Hang Yan, Antoine Le Roux, Kumaraswamy Boyapelly, Anne-Marie Lamontagne, Marie-Ann Archambault, Frédéric Picard-Jean, David Lalonde-Seguin, Emilie St-Pierre, Rafael J Najmanovich, Louis-Charles Fortier, Daniel Lafontaine, Éric Marsault
Riboswitches recently emerged as possible targets for the development of alternative antimicrobial approaches. Guanine-sensing riboswitches in the bacterial pathogen Clostridioides difficile (formerly known as Clostridium difficile) constitute potential targets based on their involvement in the regulation of basal metabolic control of purine compounds. In this study, we deciphered the structure-activity relationship of several guanine derivatives on the guanine riboswitch and determined their antimicrobial activity...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220567/the-structural-basis-of-the-histone-demethylase-kdm6b-histone-3-lysine-27-specificity
#12
Sarah Elizabeth Jones, Lars Olsen, Michael Gajhede
KDM subfamily 6 enzymes KDM6A and KDM6B specifically catalyse demethylation of di-/tri-methylated lysine on Histone 3 lysine 27 (H3K27me3/2) and play an important role in repression of developmental genes. Despite identical amino acid sequence in the immediate surroundings of H3K9me3/2 (ARKS) the enzymes do not catalyse demethylation of this general marker of repression. In order to address this question for KDM6B we used computational methods to identify H3(17-33) derived peptides with improved binding affinity, that would enable co-crystallization with the catalytic core of human KDM6B (ccKDM6B)...
December 8, 2017: Biochemistry
https://www.readbyqxmd.com/read/29220542/safety-and-efficacy-of-apremilast-through-104-weeks-in-patients-with-moderate-to-severe-psoriasis-who-continued-on-apremilast-or-switched-from-etanercept-treatment-findings-from-the-liberate-study
#13
K Reich, M Gooderham, A Bewley, L Green, J Soung, R Petric, J Marcsisin, J Cirulli, R Chen, V Piguet
BACKGROUND: Apremilast, an oral phosphodiesterase 4 inhibitor, has demonstrated efficacy in patients with moderate to severe psoriasis. OBJECTIVE: To evaluate long-term efficacy and safety of apremilast in biologic-naive patients with moderate to severe plaque psoriasis and safety of switching from etanercept to apremilast in the phase 3b LIBERATE trial. METHODS: Two hundred fifty patients were randomized to placebo, apremilast 30 mg BID, or etanercept 50 mg QW through Week 16; thereafter, all patients continued or switched to apremilast through Week 104 (extension phase)...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29220534/effects-of-acupuncture-treatment-on-fibromyalgia-symptoms-serotonin-and-substance-p-levels-a-randomized-sham-and-placebo-controlled-clinical-trial
#14
Saliha Karatay, Sibel Caglar Okur, Hulya Uzkeser, Kadir Yildirim, Fatih Akcay
Objective: The aim of this study was to evaluate the effects of acupuncture treatment on serum levels of serotonin and substance P (SP) as well as on clinical parameters in patients with fibromyalgia (FM). Methods: This is a randomized controlled clinical trial. Seventy-five women with FM were randomized into one of three kinds of acupuncture treatment: real acupuncture group (AcG), sham acupuncture group (ShG), and simulated acupuncture group (SiG). Treatments were applied semiweekly for four weeks...
December 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29220359/synthesis-of-novel-purpurealidin-analogs-and-evaluation-of-their-effect-on-the-cancer-relevant-potassium-channel-kv10-1
#15
Lien Moreels, Chinmay Bhat, Manuela Voráčová, Steve Peigneur, Hannah Goovaerts, Eero Mäki-Lohiluoma, Farrah Zahed, Luis A Pardo, Jari Yli-Kauhaluoma, Paula Kiuru, Jan Tytgat
In the search for novel anticancer drugs, the potassium channel KV10.1 has emerged as an interesting cancer target. Here, we report a new group of KV10.1 inhibitors, namely the purpurealidin analogs. These alkaloids are produced by the Verongida sponges and are known for their wide variety of bioactivities. In this study, we describe the synthesis and characterization of 27 purpurealidin analogs. Structurally, bromine substituents at the central phenyl ring and a methoxy group at the distal phenyl ring seem to enhance the activity on KV10...
2017: PloS One
https://www.readbyqxmd.com/read/29220306/improving-spiking-dynamical-networks-accurate-delays-higher-order-synapses-and-time-cells
#16
Aaron R Voelker, Chris Eliasmith
Researchers building spiking neural networks face the challenge of improving the biological plausibility of their model networks while maintaining the ability to quantitatively characterize network behavior. In this work, we extend the theory behind the neural engineering framework (NEF), a method of building spiking dynamical networks, to permit the use of a broad class of synapse models while maintaining prescribed dynamics up to a given order. This theory improves our understanding of how low-level synaptic properties alter the accuracy of high-level computations in spiking dynamical networks...
December 8, 2017: Neural Computation
https://www.readbyqxmd.com/read/29220305/spiking-neural-classifier-with-lumped-dendritic-nonlinearity-and-binary-synapses-a-current-mode-vlsi-implementation-and-analysis
#17
Aritra Bhaduri, Amitava Banerjee, Subhrajit Roy, Sougata Kar, Arindam Basu
We present a neuromorphic current mode implementation of a spiking neural classifier with lumped square law dendritic nonlinearity. It has been shown previously in software simulations that such a system with binary synapses can be trained with structural plasticity algorithms to achieve comparable classification accuracy with fewer synaptic resources than conventional algorithms. We show that even in real analog systems with manufacturing imperfections (CV of 23.5% and 14.4% for dendritic branch gains and leaks respectively), this network is able to produce comparable results with fewer synaptic resources...
December 8, 2017: Neural Computation
https://www.readbyqxmd.com/read/29220178/equilibrium-between-a-droplet-and-surrounding-vapor-a-discussion-of-finite-size-effects
#18
Andreas Troester, Fabian Schmitz, Peter Virnau, Kurt Binder
In a theoretical description of homogeneous nucleation one frequently assumes an ``equilibrium'' coexistence of a liquid droplet with surrounding vapor of a density exceeding that of a saturated vapor at bulk vapor-liquid two-phase coexistence. Thereby one ignores the caveat that in the thermodynamic limit, for which the vapor would be called supersaturated, such states will at best be metastable with finite lifetime, and thus not be well-defined within equilibrium statistical mechanics. In contrast, in a system of finite volume stable equilibrium coexistence of droplet and supersaturated vapor at constant total density is perfectly possible, and numerical analysis of equilibrium free energies of finite systems allows to obtain physically relevant results...
December 8, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29219940/factors-influencing-postpartum-fatigue-in-vaginal-birth-women-testing-a-path-model
#19
Ching-Hsing Hsieh, Chien-Lan Chen, Tan-Ju Han, Pei-Ju Lin, Hui-Chun Chiu
BACKGROUND: Postpartum fatigue is a very common complaint among postpartum women. Although current evidence indicates that several factors (e.g., parity, epidural analgesia, perineal trauma, perineal pain, and longer second stage of labor) are associated with postpartum, not enough is known about the relationships among these physical factors simultaneously and how they contribute to the development of postpartum fatigue. Increased awareness of the complex relationships among these factors will help nurses assess, prevent, and alleviate postpartum fatigue...
December 6, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29219939/psychometric-evaluation-of-the-chinese-respiratory-distress-observation-scale-on-critically-ill-patients-with-cardiopulmonary-diseases
#20
Ya-Hsiang Chan, Hua-Shan Wu, Chih-Ching Yen, Margaret L Campbell
BACKGROUND: Respiratory distress is a common and distressing experience that strikes most critically ill patients with cardiopulmonary diseases. Now, most dyspnea assessment tools rely on patient's self-report. Only one instrument, the Respiratory Distress Observation Scale (RDOS), is valid for assessing respiratory distress when the patient cannot provide a dyspnea self-report. PURPOSE: The aims of this study were to develop the Chinese version of RDOS through two-way translation and examine its reliability and validity...
December 6, 2017: Journal of Nursing Research: JNR
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