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https://www.readbyqxmd.com/read/28319852/pterostilbene-a-dimethylated-analog-of-resveratrol-promotes-energy-metabolism-in-obese-rats
#1
Koji Nagao, Tomoyuki Jinnouchi, Shunichi Kai, Teruyoshi Yanagita
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a dimethylated analog of resveratrol and has been reported to exert various pharmacological effects. In this study, we evaluated the effect of pterostilbene on the pathogenesis of obesity and energy metabolism in obese rats. Pterostilbene significantly activates silent mating type information regulation 2 homolog-1 and peroxisome proliferator-activated receptor-alpha in vitro. At 4 weeks a 0.5% pterostilbene diet markedly suppressed the abdominal white adipose tissue (WAT) accumulation in obese rats...
March 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28319665/synthesis-of-four-disulfide-insulin-analogs-via-sequential-disulfide-bond-formation
#2
Fangzhou Wu, John P Mayer, Vasily G Gelfanov, Fa Liu, Richard D DiMarchi
Naturally-occurring, multiple cysteine-containing peptides are a structurally unique class of compounds with a wide range of therapeutic and diagnostic applications. The development of reliable, and precise chemical methods for their preparation is of paramount importance to facilitate exploration of their utility. We report an efficient approach based on stepwise, sequentially directed disulfide bond formation, exemplified here by the synthesis of four-disulfide bond containing insulin analogs. The cysteine protections consisted of tert-butylthiol (StBu), thiol-trimethoxyphenyl (STmp), trityl (Trt), 4-methoxytrityl (Mmt), S-acetamidomethyl (Acm) and tert-butyl (tBu)...
March 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28319468/the-impact-of-cage-dimensions-positioning-and-side-of-approach-in-extreme-lateral-interbody-fusion
#3
Marjan Alimi, Gernot Lang, Rodrigo Navarro-Ramirez, Moritz Perrech, Connor Berlin, Christoph P Hofstetter, Yu Moriguchi, Eric Elowitz, Roger Härtl
STUDY DESIGN: This is a retrospective single-center study. OBJECTIVE: The aim of the study was to evaluate the impact of cage characteristics and position toward clinical and radiographic outcome measures in patients undergoing extreme lateral interbody fusion (ELIF). SUMMARY OF BACKGROUND DATA: ELIF is utilized for indirect decompression and minimally invasive surgical treatment for various degenerative spinal disorders. However, evidence regarding the influence of cage characteristics in patient outcome is minimal...
March 17, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28319431/evaluation-of-the-risk-factors-for-a-rotator-cuff-retear-after-repair-surgery
#4
Yeong Seok Lee, Jeung Yeol Jeong, Chan-Deok Park, Seung Gyoon Kang, Jae Chul Yoo
BACKGROUND: A retear is a significant clinical problem after rotator cuff repair. However, no study has evaluated the retear rate with regard to the extent of footprint coverage. PURPOSE: To evaluate the preoperative and intraoperative factors for a retear after rotator cuff repair, and to confirm the relationship with the extent of footprint coverage. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Data were retrospectively collected from 693 patients who underwent arthroscopic rotator cuff repair between January 2006 and December 2014...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28319426/high-satisfaction-and-return-to-sports-after-total-shoulder-arthroplasty-in-patients-aged-55-years-and-younger
#5
Grant H Garcia, Joseph N Liu, Alec Sinatro, Hao-Hua Wu, Joshua S Dines, Russell F Warren, David M Dines, Lawrence V Gulotta
BACKGROUND: Young, active candidates for total shoulder arthroplasty (TSA) are a unique group of patients. Not only do they demand longevity and improved function, but they also desire a return to physical activities. PURPOSE: To determine the rate of return to sports in patients aged ≤55 years undergoing TSA. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This was a retrospective review of consecutive patients who underwent anatomic TSA at a single institution...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28319176/insight-into-the-mechanism-of-action-of-temporin-sha-a-new-broad-spectrum-antiparasitic-and-antibacterial-agent
#6
Zahid Raja, Sonia André, Feten Abbassi, Vincent Humblot, Olivier Lequin, Tahar Bouceba, Isabelle Correia, Sandra Casale, Thierry Foulon, Denis Sereno, Bruno Oury, Ali Ladram
Antimicrobial peptides (AMPs) are promising drugs to kill resistant pathogens. In contrast to bacteria, protozoan parasites, such as Leishmania, were little studied. Therefore, the antiparasitic mechanism of AMPs is still unclear. In this study, we sought to get further insight into this mechanism by focusing our attention on temporin-SHa (SHa), a small broad-spectrum AMP previously shown to be active against Leishmania infantum. To improve activity, we designed analogs of SHa and compared the antibacterial and antiparasitic mechanisms...
2017: PloS One
https://www.readbyqxmd.com/read/28318969/auditory-perceptual-evaluation-of-voice-quality-of-cochlear-implanted-and-normal-hearing-individuals-a-reliability-study
#7
Ana Cristina Coelho, Alcione Ghedini Brasolotto, Ana Carolina Nascimento Fernandes, Daniela Malta de Souza Medved, Eduardo Magalhães da Silva, Fayez Bahmad Júnior
OBJECTIVE: This study aimed to present an experience in rating voices of adults with normal hearing and adults with cochlear implants and critically examine the outcomes, discussing pros and cons of the methodology used. STUDY DESIGN: This is a cross-sectional, prospective study. METHODS: One hundred and fifty voice samples, consisting of 50 sustained vowels, 50 samples of connected speech, and 50 samples of conversational speech, belonging to 25 adults with hearing impairment with cochlear implants and 25 adults with normal hearing, were perceptually analyzed for inter-rater agreement and intra-rater reliability...
March 16, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28318942/cyclic-mu-opioid-receptor-ligands-containing-multiple-n-methylated-amino-acid-residues
#8
Anna Adamska-Bartłomiejczyk, Anna Janecka, Márton Richárd Szabó, Maria Camilla Cerlesi, Girolamo Calo, Alicja Kluczyk, Csaba Tömböly, Attila Borics
In this study we report the in vitro activities of four cyclic opioid peptides with various sequence length/macrocycle size and N-methylamino acid residue content. N-Methylated amino acids were incorporated and cyclization was employed to enhance conformational rigidity to various extent. The effect of such modifications on ligand structure and binding properties were studied. The pentapeptide containing one endocyclic and one exocyclic N-methylated amino acid displayed the highest affinity to the mu-opioid receptor...
March 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28318925/retrospective-evaluation-of-three-different-joint-surgeries-for-internal-derangements-of-the-temporomandibular-joint
#9
Celal Candirli, Mehmet Demirkol, Onur Yilmaz, Sadi Memis
PURPOSE: To compare the outcomes achieved with eminectomy, discectomy alone, and discectomy with an abdominal dermis fat graft (D + ADFG) in the treatment of internal derangements (IDs) of the temporomandibular joint (TMJ), and to briefly discuss the failed cases in which a second operation was needed. PATIENTS AND METHODS: This was a retrospective study of 31 patients (27 females, 4 males) who were unresponsive to conservative therapy and therefore underwent eminectomy (group A, n = 6), discectomy alone (group B, n = 8), or D + ADFG (group C, n = 17)...
February 13, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28318860/a-prospective-randomized-trial-comparing-liposomal-bupivacaine-vs-fascia-iliaca-compartment-block-for-postoperative-pain-control-in-total-hip-arthroplasty
#10
Molly A McGraw-Tatum, Michael T Groover, Nicole E George, John S Urse, Victor Heh
BACKGROUND: Increasing demand for total hip arthroplasty (THA) in a climate of increasing focus on clinical outcomes, patient satisfaction, and cost has created a need for better acute postoperative pain control for patients. An ideal pain control method would have few side effects, decreased opioid consumption, improved pain control, early ambulation, and decreased hospital length of stay (LOS). METHODS: We performed a prospective randomized, controlled study involving 79 patients undergoing elective THA between June 2015 and February 2016...
February 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28318850/safety-and-efficacy-of-hyperosmolar-irrigation-solution-in-shoulder-arthroscopy
#11
Nicholas M Capito, James L Cook, Bernardo Yahuaca, Marie D Capito, Seth L Sherman, Matthew J Smith
BACKGROUND: A hyperosmolar irrigation solution has been reported to be safe and have potential benefits for use during shoulder arthroscopy in an animal model study. In this study, the clinical effects of a hyperosmolar solution were compared with a standard isotonic solution when used for shoulder arthroscopy. METHODS: A prospective, double-blind, randomized controlled trial was performed to compare isotonic (273 mOsm/L) and hyperosmolar (593 mOsm/L) irrigation solutions used for arthroscopic rotator cuff repair...
March 15, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28318848/randomized-controlled-trial-of-supervised-physiotherapy-versus-a-home-exercise-program-after-hydrodilatation-for-the-management-of-primary-frozen-shoulder
#12
Paul M Robinson, Jennie Norris, Christopher P Roberts
HYPOTHESIS AND BACKGROUND: Hydrodilatation and physiotherapy are commonly used treatments for primary frozen shoulder. Little is known about the optimal form of physiotherapy. This study reports a randomized controlled trial comparing 2 forms of physiotherapy after hydrodilatation. The null hypothesis was that there would be no difference between the 2 groups at 1 year as measured by the Oxford Shoulder Score (OSS). METHODS: We randomized 41 patients undergoing hydrodilatation for primary frozen shoulder into 2 treatment groups: group 1 (n = 20) underwent supervised physiotherapy in addition to a home exercise program, and group 2 (n = 21) followed a self-directed home exercise program in isolation...
March 15, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28318814/integrated-yoga-and-naturopathy-module-in-management-of-metabolic-syndrome-a-case-report
#13
Swathi Gowda, Sriloy Mohanty, Apar Saoji, Raghuram Nagarathna
A 50-year-old male participant with sedentary lifestyle, diagnosed with Metabolic Syndrome (MetS) [obesity, Type-2 diabetes mellitus, hypertension] and hypothyroidism since 2013, was administered integrated Yoga and Naturopathy (IYN) for 6 weeks as a tailor made individualized protocol at the residential integrative medical facility in Bangalore between October and November 2015. The results showed reduction in weight (97.9 kg to 74.6 kg), Body Mass Index (BMI) (35.1 kg/m(2) to 27.86 kg/m(2)), total cholesterol (192 mg% to 145 mg%), triglycerides (153 mg% to 90 mg%), Low Density Lipoprotein (LDL) (124 mg% to 81 mg%), High Density Lipoprotein (HDL) (40 mg% to 46 mg%), fasting blood glucose (110 mg/dl to 75 mg/dl), postprandial glucose (267 mg/dl to 100 mg/dl), glycated hemoglobin (HbA1c) (7...
March 16, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28318582/purulent-vaginal-discharge-in-grazing-dairy-cows-risk-factors-reproductive-performance-and-prostaglandin-f2%C3%AE-treatment
#14
M J Giuliodori, M Magnasco, R P Magnasco, I M Lacau-Mengido, R L de la Sota
The objectives of this study were to assess the association of a 4-point scale of vaginal discharge score (VDS) with time to pregnancy to define criteria for a practical case of purulent vaginal discharge (PVD) in dairy cows, to test the risk factors for PVD, and, finally, the effect of a dose of PGF2α on cure and reproductive performance. In experiment 1, grazing Holstein cows (n = 2,414) had their vaginal discharge scored at ∼32 d in milk (DIM) on a 4-point scale, the effect of VDS on the hazard of pregnancy by 300 DIM was then assessed to derive a case definition of PVD...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28318455/airway-management-in-disaster-response-a-manikin-study-comparing-direct-and-video-laryngoscopy-for-endotracheal-intubation-by-prehospital-providers-in-level-c-personal-protective-equipment
#15
Sami Yousif, Jason T Machan, Yasser Alaska, Selim Suner
Introduction Airway management is one of many challenges that medical providers face in disaster response operations. The use of personal protective equipment (PPE), in particular, was found to be associated with higher failure rates and a prolonged time to achieve airway control. Hypothesis/Problem The objective of this study was to determine whether video laryngoscopy could facilitate the performance of endotracheal intubation by disaster responders wearing Level C PPE. METHODS: In this prospective, randomized, crossover study, a convenience sample of practicing prehospital providers were recruited...
March 20, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28318302/isolated-subscapularis-repair-in-irreparable-posterosuperior-massive-rotator-cuff-tears-involving-the-subscapularis-tendon
#16
Sung-Jae Kim, Yun-Rak Choi, Min Jung, Won-Yong Lee, Yong-Min Chun
BACKGROUND: No previous study has examined whether isolated subscapularis tendon repair in irreparable posterosuperior massive rotator tears involving the subscapularis tendon in relatively young patients without arthritis can yield satisfactory outcomes. HYPOTHESIS: We hypothesized that this procedure would produce favorable outcomes in patients who might otherwise be candidates for reverse arthroplasty. STUDY DESIGN: Case series; Level of evidence, 4...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28318229/tracing-effects-of-fluorine-substitutions-on-g-quadruplex-conformational-changes
#17
Jonathan Dickerhoff, Linn Haase, Walter Langel, Klaus Weisz
A human telomere sequence that folds into an intramolecular (3+1)-hybrid G-quadruplex was modified by the incorporation of 2'-fluoro-2'-deoxyriboguanosines ((F)G) into syn positions of its outer tetrad. A circular dichroism and NMR spectral analysis reveals a nearly quantitative switch of the G-tetrad polarity with concerted syn↔anti transitions of all four G residues. These observations follow findings on a (F)G-substituted (3+1)-hybrid quadruplex with a different fold, suggesting a more general propensity of hybrid-type quadruplexes to undergo a tetrad polarity reversal...
March 20, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28317899/minocycline-treatment-suppresses-juvenile-development-and-growth-by-attenuating-insulin-tor-signaling-in-drosophila-animal-model
#18
Hyun Myoung Yun, Sujin Noh, Seogang Hyun
Minocycline is a broad spectrum, semi-synthetic tetracycline analog that is used to treat bacterial infection. Recently, this drug has been receiving increasing attention for its non-antibiotic properties, including anti-inflammatory, tumor suppressive, and neuroprotective effects. Drosophila is a useful model organism for studying human metabolism and disease. In this study, we investigated the effects of minocycline on juvenile development and growth in Drosophila. Feeding minocycline to Drosophila larvae suppresses larval body growth and delays the timing of pupation in a dose-dependent manner...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317807/tetrahydro-2-furanyl-2-4-1h-3h-pyrimidinedione-derivatives-as-novel-antibacterial-compounds-against-mycobacterium
#19
Yuji Koseki, Hironori Kanetaka, Joji Tsunosaki, Héléne Munier-Lehmann, Shunsuke Aoki
OBJECTIVE/BACKGROUND: Mycobacterium tuberculosis thymidine monophosphate kinase (mtTMPK) is a potential enzymatic target for the treatment of tuberculosis (TB). MATERIALS AND METHODS: In this study, we performed pharmacophore-based in silico screening, targeting mtTMPK with a compound library of 461,383 chemicals. We evaluated the candidate compounds for inhibitory effects on the growth of the model mycobacteria, Mycobacterium smegmatis. RESULTS: The compound KTP3 completely inhibited the growth of M...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317772/ultrasensitive-detection-of-clenbuterol-by-a-covalent-imprinted-polymer-as-a-biomimetic-antibody
#20
Yiwei Tang, Jingwen Gao, Xiuying Liu, Xue Gao, Tao Ma, Xiaonan Lu, Jianrong Li
As an ideal biomimetic antibody, molecularly imprinted polymer (MIP) has shown great promise in immunoassays. Here, we developed a covalent imprinting method to prepare MIP artificial antibody towards clenbuterol on the well surface of a microtiter plate. Template molecule (clenbuterol) was splited by hydrolysis with functional monomer and removed by methanol/acetic acid solution, and then three-dimensional cavities were fabricated in the MIP, which can rebind template molecule via hydrogen bond interaction...
August 1, 2017: Food Chemistry
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