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https://www.readbyqxmd.com/read/28822774/effects-of-neuropeptides-and-sex-steroids-on-the-pituitary-gonadal-axis-of-pre-pubertal-f1-wreckfish-h%C3%A4-puku-polyprion-oxygeneios-in-vivo-evidence-of-inhibitory-effects-of-androgens
#1
Matthew J Wylie, Alvin N Setiawan, Glen W Irvine, Jane E Symonds, Abigail Elizur, P Mark Lokman
The ability to advance puberty in broodstock that have a long generation interval and mature at large size is a highly valuable tool in contemporary aquaculture enterprise. Juvenile male and female wreckfish 'hāpuku' (Polyprion oxygeneios), a candidate for commercialization in aquaculture, were subjected to treatment for 8 weeks with two implants, one containing steroid (blank; estradiol-17β, E2; 11-ketotestosterone, KT; 17 α -methyltestosterone, MT), the other peptide (blank; gonadotropin-releasing hormone analog, GnRHa; kisspeptin, Kiss2-12)...
August 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28822772/differentiation-of-candida-albicans-candida-glabrata-and-candida-krusei-by-ft-ir-and-chemometrics-by-chromagar%C3%A2-candida
#2
Denise Wohlmeister, Débora Renz Barreto Vianna, Virginia Etges Helfer, Luciane Noal Calil, Andréia Buffon, Alexandre Meneghello Fuentefria, Valeriano Antonio Corbellini, Diogo André Pilger
Pathogenic Candida species are detected in clinical infections. CHROMagar™ is a phenotypical method used to identify Candida species, although it has limitations, which indicates the need for more sensitive and specific techniques. Infrared Spectroscopy (FT-IR) is an analytical vibrational technique used to identify patterns of metabolic fingerprint of biological matrixes, particularly whole microbial cell systems as Candida sp. in association of classificatory chemometrics algorithms. On the other hand, Soft Independent Modeling by Class Analogy (SIMCA) is one of the typical algorithms still little employed in microbiological classification...
August 16, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28822641/clinical-and-radiographic-outcomes-with-assessment-of-the-learning-curve-in-arthroscopically-assisted-latissimus-dorsi-tendon-transfer-for-irreparable-posterosuperior-rotator-cuff-tears
#3
Kotaro Yamakado
PURPOSE: To evaluate the clinical results of an arthroscopy-assisted latissimus dorsi tendon transfer (aLD) for irreparable posterosuperior cuff tears as a primary surgery. The secondary aim of this study was to quantify the learning curve using the log-linear model. We hypothesized that aLD significantly improved shoulder function and that there was consistent reduction of the operative time in support of a learning-curve effect. METHODS: After the arthroscopic partial repair was completed, the latissimus dorsi tendon was harvested via axillary mini-open incision and fixed with a knotless anchor arthroscopically...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822640/comparison-of-outcomes-1%C3%A2-year-after-rotator-cuff-repair-with-and-without-concomitant-biceps-surgery
#4
Scott T Watson, Christopher B Robbins, Asheesh Bedi, James E Carpenter, Joel J Gagnier, Bruce S Miller
PURPOSE: To compare the outcomes of patients who undergo a long head of the biceps (LHB) procedure (tenotomy or tenodesis) concomitant with rotator cuff repair (RCR) to those of patients who undergo isolated RCR. METHODS: Prospectively collected data were retrospectively reviewed on 80 patients, >18 years old, who underwent repair of a full-thickness rotator cuff tear and with 1-year patient-reported outcome scores collected June 2012 to March 2015. The exclusion criteria were concomitant procedures other than LHB tenotomy, tenodesis, or subacromial decompression; prior shoulder surgery; or other shoulder pathology...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822091/effect-of-ap102-a-subtype-2-and-5-specific-somatostatin-analog-on-glucose-metabolism-in-rats
#5
Erika Tarasco, Petra Seebeck, Svende Pfundstein, Adrian F Daly, Philippe J Eugster, Alan G Harris, Eric Grouzmann, Thomas A Lutz, Christina N Boyle
PURPOSE: Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies...
August 18, 2017: Endocrine
https://www.readbyqxmd.com/read/28821929/magnetic-resonance-cinematography-of-the-fingers-a-3-0-tesla-feasibility-study-with-comparison-of-incremental-and-continuous-dynamic-protocols
#6
Thomas Bayer, Werner Adler, Rolf Janka, Michael Uder, Frank Roemer
OBJECTIVE: To study the feasibility of magnetic resonance cinematography of the fingers (MRCF) with comparison of image quality of different protocols for depicting the finger anatomy during motion. MATERIALS AND METHODS: MRCF was performed during a full flexion and extension movement in 14 healthy volunteers using a finger-gating device. Three real-time sequences (frame rates 17-59 images/min) and one proton density (PD) sequence (3 images/min) were acquired during incremental and continuous motion...
August 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28821906/comparing-pain-reduction-following-kyphoplasty-and-vertebroplasty-a-meta-analysis-of-randomized-and-non-randomized-controlled-trials
#7
Chen Chen, Xiaofeng Shen, Jiangping Wang, Zhigang Zhang, Yuwei Li, Hua Chen
PURPOSE: The aim of the study was to compare the extent of pain reduction with kyphoplasty (KP) and vertebroplasty (VP) in the treatment of osteoporotic vertebral compression fractures (OVCF) using a visual analog scale (VAS). METHODS: A computerized database search was performed to compare pain relief from VP and KP in OVCF. The available literature was analysed to quantify the amount of pain reduction using VAS as the primary outcome. RESULTS: A total of 10 studies encompassing 902 patients met the inclusion criteria...
August 18, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28821844/n-glycosylation-triggers-a-dual-selection-pressure-in-eukaryotic-secretory-proteins
#8
Máximo Lopez Medus, Gabriela E Gomez, Lucía F Zacchi, Paula M Couto, Carlos A Labriola, María S Labanda, Rodrigo Corti Bielsa, Eugenia M Clérico, Benjamin L Schulz, Julio J Caramelo
Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum. N-glycans fulfill multiple structural and biological functions, and are crucial for productive folding of many glycoproteins. N-glycosylation involves the attachment of an oligosaccharide to selected asparagine residues in the sequence N-X-S/T (X ≠ P), a motif known as an N-glycosylation'sequon'. Mutations that create novel sequons can cause disease due to the destabilizing effect of a bulky N-glycan...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821776/mineralization-and-preservation-of-an-extremotolerant-bacterium-isolated-from-an-early-mars-analog-environment
#9
F Gaboyer, C Le Milbeau, M Bohmeier, P Schwendner, P Vannier, K Beblo-Vranesevic, E Rabbow, F Foucher, P Gautret, R Guégan, A Richard, A Sauldubois, P Richmann, A K Perras, C Moissl-Eichinger, C S Cockell, P Rettberg, Marteinsson, E Monaghan, P Ehrenfreund, L Garcia-Descalzo, F Gomez, M Malki, R Amils, P Cabezas, N Walter, F Westall
The artificial mineralization of a polyresistant bacterial strain isolated from an acidic, oligotrophic lake was carried out to better understand microbial (i) early mineralization and (ii) potential for further fossilisation. Mineralization was conducted in mineral matrixes commonly found on Mars and Early-Earth, silica and gypsum, for 6 months. Samples were analyzed using microbiological (survival rates), morphological (electron microscopy), biochemical (GC-MS, Microarray immunoassay, Rock-Eval) and spectroscopic (EDX, FTIR, RAMAN spectroscopy) methods...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821717/promysalin-is-a-salicylate-containing-antimicrobial-with-a-cell-membrane-disrupting-mechanism-of-action-on-gram-positive-bacteria
#10
Rahul D Kaduskar, Giulia Della Scala, Zaaima J H Al Jabri, Stefania Arioli, Loana Musso, Marco R Oggioni, Sabrina Dallavalle, Diego Mora
Promysalin was previously described as a narrow spectrum molecule with a unique species-specific activity against Pseudomonas aeruginosa. Here we demonstrate that promysalin is active against Gram-positive and Gram-negative bacteria using a microdilution assay. Promysalin acts on Gram-positive bacteria with a mechanism of action involving cell membrane damage with leakage of intracellular components. The evaluation of MICs and MBCs on 11 promysalin analogs, synthesized utilizing diverted total synthesis, allowed the identification of the structural moieties potentially involved in cell membrane interaction and damage...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821607/two-plant-derived-aporphinoid-alkaloids-exert-their-antifungal-activity-by-disrupting-mitochondrial-iron-sulfur-cluster-biosynthesis
#11
Siddharth K Tripathi, Tao Xu, Qin Feng, Bharathi Avula, Xiaomin Shi, Xuewen Pan, Melanie M Mask, Scott R Baerson, Melissa R Jacob, Ranga Rao Ravu, Shabana I Khan, Xing-Cong Li, Ikhlas A Khan, Alice M Clark, Ameeta K Agarwal
Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans However, the molecular mechanism of this antifungal activity is unknown. In this study, we show that eupolauridine 9591 (E9591), a synthetic analog of eupolauridine, and liriodenine methiodide (LMT), a methiodide salt of liriodenine, mediate their antifungal activities by disrupting mitochondrial iron-sulfur (Fe-S) cluster synthesis...
August 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28821542/human-hepatocyte-metabolism-of-novel-synthetic-cannabinoids-mn-18-and-its-5-fluoro-analog-5f-mn-18
#12
Xingxing Diao, Jeremy Carlier, Mingshe Zhu, Marilyn A Huestis
BACKGROUND: In 2014, 2 novel synthetic cannabinoids, MN-18 and its 5-fluoro analog, 5F-MN-18, were first identified in an ongoing survey of novel psychoactive substances in Japan. In vitro pharmacological assays revealed that MN-18 and 5F-MN-18 displayed high binding affinities to human CB1 and CB2 receptors, with Ki being 1.65-3.86 nmol/L. MN-18 and 5F-MN-18 were scheduled in Japan and some other countries in 2014. Despite increasing prevalence, no human metabolism data are currently available, making it challenging for forensic laboratories to confirm intake of MN-18 or 5F-MN-18...
August 18, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28821458/dipeptidyl-peptidase-iv-and-quorum-sensing-signaling-in-biofilm-related-virulence-of-prevotella-aurantiaca
#13
Dareen Fteita, Ahmed Ali Musrati, Eija Könönen, Xiaochu Ma, Mervi Gürsoy, Markus Peurla, Eva Söderling, Herman O Sintim, Ulvi Kahraman Gürsoy
Biofilm formation and dipeptidyl peptidase IV (DPPIV) enzyme activity contribute to the virulence of oral bacteria, and these virulence factors are partly regulated by quorum sensing signaling system. We recently demonstrated that estradiol regulates growth properties and DPPIV activity of Prevotella intermedia, Prevotella nigrescens, and Prevotella pallens. Here, we examined the DPPIV dependency of biofilm formation of Prevotella aurantiaca. Three strains (two clinical strains AHN 37505 and 37552 and the type strain CCUG 57723) were incubated in three estradiol concentrations (30, 90, and 120 nmol/L)...
August 15, 2017: Anaerobe
https://www.readbyqxmd.com/read/28821320/reduced-neural-responses-to-food-cues-might-contribute-to-the-anorexigenic-effect-of-acute-exercise-observed-in-obese-but-not-lean-adolescents
#14
S N Fearnbach, L Silvert, B Pereira, Y Boirie, M Duclos, K L Keller, D Thivel
Acute exercise has been found to reduce subsequent energy intake in obese adolescents. Although it has been suggested that some neural pathways are involved in this post-exercise energy intake regulation, it remains unknown whether the post-exercise attentional response to food cues differs as a function of weight status. We hypothesize that there will be a reduction in the neural response to food cues as a result of exercise in obese adolescents, but not in their lean counterparts. Fourteen obese and 14 lean adolescent boys (12-15 years) were randomized (within-subjects design) to remain seated (CON) or to exercise 45 minutes at 65% of their maximal capacities (EX)...
August 2017: Nutrition Research
https://www.readbyqxmd.com/read/28820972/fluorescent-pseudorotaxanes-of-a-quinodicarbocyanine-dye-with-gamma-cyclodextrin
#15
Olivia M Bernstein, Tiffany E McGee, Lisa E Silzel, John W Silzel
Spectrophotometric titration of buffered solutions of gamma cyclodextrin (γCD) and 1,1'-diethyl,2,2'-dicarbocyanine (DDI) demonstrates extension of the known 1:2 host:guest complex to form a previously unreported 2:2 complex near the γCD solubility limit. Though DDI is predominantly hosted as a non-fluorescent H-aggregate, both complexes exist in respective equilibria with two secondary complexes hosting unaggregated DDI as 1:1 and 2:1 complexes. The 2:1 complex exhibits significant fluorescence emission, with a quantum yield six times that of DDI in organic solvents, but ten times lower than that of an analogous indodicarbocyanine...
August 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28820949/association-between-patient-factors-and-outcome-of-synthetic-cartilage-implant-hemiarthroplasty-vs-first-metatarsophalangeal-joint-arthrodesis-in-advanced-hallux-rigidus
#16
Andy Goldberg, Dishan Singh, Mark Glazebrook, Chris M Blundell, Gwyneth De Vries, Ian L D Le, Dominic Nielsen, M Elizabeth Pedersen, Anthony Sakellariou, Matthew Solan, Alastair S E Younger, Timothy R Daniels, Judith F Baumhauer
BACKGROUND: We evaluated data from a clinical trial of first metatarsophalangeal joint (MTPJ1) implant hemiarthroplasty and arthrodesis to determine the association between patient factors and clinical outcomes. METHODS: Patients ≥18 years with hallux rigidus grade 2, 3, or 4 were treated with synthetic cartilage implant MTPJ1 hemiarthroplasty or arthrodesis. Pain visual analog scale (VAS), Foot and Ankle Ability Measure (FAAM) sports and activities of daily living (ADL) scores, and Short Form-36 Physical Function (SF-36 PF) subscore were obtained preoperatively, and at 2, 6, 12, 24, 52, and 104 weeks postoperatively...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28820912/impact-of-novel-palmitoylated-prolactin-releasing-peptide-analogs-on-metabolic-changes-in-mice-with-diet-induced-obesity
#17
Veronika Pražienková, Martina Holubová, Helena Pelantová, Martina Bugáňová, Zdenko Pirník, Barbora Mikulášková, Andrea Popelová, Miroslava Blechová, Martin Haluzík, Blanka Železná, Marek Kuzma, Jaroslav Kuneš, Lenka Maletínská
Analogs of anorexigenic neuropeptides, such as prolactin-releasing peptide (PrRP), have a potential as new anti-obesity drugs. In our previous study, palmitic acid attached to the N-terminus of PrRP enabled its central anorexigenic effects after peripheral administration. In this study, two linkers, γ-glutamic acid at Lys11 and a short, modified polyethylene glycol at the N-terminal Ser and/or Lys11, were applied for the palmitoylation of PrRP31 to improve its bioavailability. These analogs had a high affinity and activation ability to the PrRP receptor GPR10 and the neuropeptide FF2 receptor, as well as short-term anorexigenic effect similar to PrRP palmitoylated at the N-terminus...
2017: PloS One
https://www.readbyqxmd.com/read/28820793/codeine-plus-acetaminophen-for-pain-after-photorefractive-keratectomy-a-randomized-double-blind-placebo-controlled-add-on-trial
#18
Vinicius B P Pereira, Renato Garcia, Andre A M Torricelli, Adriana Mukai, Samir J Bechara
BACKGROUND: Pain after photorefractive keratectomy (PRK) is significant, and the analgesic efficacy and safety of oral opioids in combination with acetaminophen has not been fully investigated in PRK trials. PURPOSE: To assess the efficacy and safety of the combination of codeine plus acetaminophen (paracetamol) versus placebo as an add-on therapy for pain control after PRK. STUDY DESIGN: Randomized, double-blind, placebo-controlled trial...
August 17, 2017: Cornea
https://www.readbyqxmd.com/read/28820742/spatial-valley-separation-in-strained-graphene-pn-junction
#19
HongYu Tian, Jun Wang
Valleytronics in analogy to spintronics aims to use the electron valley degree of freedom to carry and manipulate information, and one of urgent tasks in this field is to generate valley-polarized electrons. In this work, we propose using the electron focusing effect in a strained graphene pn junction to separate valleys spatially through a beam of valley-unpolarized electrons, since the strain-induced pseudo-gauge potentials are opposite for K and [Formula: see text] valleys and severely affect the trajectories of K and [Formula: see text] electron propagation...
August 18, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28820533/actinomycetes-still-a-source-of-novel-antibiotics
#20
REVIEW
Olga Genilloud
Covering: 2006 to 2017Actinomycetes have been, for decades, one of the most important sources for the discovery of new antibiotics with an important number of drugs and analogs successfully introduced in the market and still used today in clinical practice. The intensive antibacterial discovery effort that generated the large number of highly potent broad-spectrum antibiotics, has seen a dramatic decline in the large pharma industry in the last two decades resulting in a lack of new classes of antibiotics with novel mechanisms of action reaching the clinic...
August 18, 2017: Natural Product Reports
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