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https://www.readbyqxmd.com/read/28934798/clinical-course-of-cervical-percutaneous-epidural-neuroplasty-in-single-level-cervical-disc-disease-with-12-month-follow-up
#1
Chang Hyun Oh, Gyu Yeul Ji, Dong Ah Shin, Pyung Goo Cho, Seung Hwan Yoon
BACKGROUND: Cervical disc disease is a common and occasionally disabling condition, occurring as a natural consequence of aging in the vast majority of the adult population. Percutaneous epidural neuroplasty (PEN) has been used to deliver highly concentrated drugs for chronic neck pain and to prevent scarring in cases refractory to conventional epidural blocks. However, the clinical course after PEN in cervical disc disease is not well-documented. OBJECTIVE: The purpose of this study was to evaluate the efficacy of cervical PEN for single-level cervical disc disease...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934796/decompressive-l5-transverse-processectomy-for-bertolotti-s-syndrome-a-preliminary-study
#2
Chang Il Ju, Seok Won Kim, Jong Gyue Kim, Seung Myung Lee, Ho Shin, Hyeun Young Lee
BACKGROUND: Bertolotti's syndrome is a spinal disorder characterized by abnormal enlargement of the transverse process of the most caudal lumbar vertebra. The L5 transverse process may be enlarged either unilaterally or bilaterally and may articulate or fuse with the sacrum or ilium. Pseudoarticulation between the transverse process of the L5 and the alar of the sacrum can cause buttock pain and leg pain. In addition, the L4 exiting nerve root could be compressed by an enlarged L5 transverse process...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934785/1-year-results-of-a-randomized-controlled-trial-of-conservative-management-vs-minimally-invasive-surgical-treatment-for-sacroiliac-joint-pain
#3
Julius Dengler Dengler, Djaya Kools, Robert Pflugmacher, Alessandro Gasbarrini, Domenico Prestamburgo, Paolo Gaetani, Eddie van Eeckhoven, Daniel Cher, Bengt Sturesson
BACKGROUND: Low back pain (LBP) emanating from the sacroiliac joint (SIJ) is a common finding. Devices to fuse the SIJ are now commercially available, but high-quality evidence supporting their effectiveness is limited. OBJECTIVES: To compare the safety and effectiveness of conservative management (CM) to minimally invasive sacroiliac joint fusion (SIJF) in patients with chronic LBP originating from the SIJ. STUDY DESIGN: Prospective, multicenter randomized controlled trial...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934778/the-effect-of-early-use-of-supplemental-therapy-on-preventing-postherpetic-neuralgia-a-systematic-review-and-meta-analysis
#4
Xiu-Fang Xing, Zhen-Feng Zhou, Feng-Jiang Zhang, Min Yan
BACKGROUND: Postherpetic neuralgia (PHN) is the most common and refractory complication of herpes zoster (HZ). Aggressive treatment of acute pain in HZ has the potential to prevent the development of PHN, but the preventive efficacy of supplemental therapy commonly used in clinical practice is controversial. OBJECTIVES: Our aim is to examine the efficacy of supplemental therapy in preventing PHN. STUDY DESIGN: A meta-analysis. SETTING: All of the selected studies are randomized controlled trials (RCTs)...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934696/synthesis-and-application-of-a-plastic-antibody-in-electrochemical-microfluidic-platform-for-oxytocin-determination
#5
Piyush Sindhu Sharma, Zofia Iskierko, Krzysztof Noworyta, Maciej Cieplak, Pawel Borowicz, Wojciech Lisowski, Francis D'Souza, Wlodzimierz Kutner
By means of molecular imprinting of a conducting polymer, molecular cavities selective for oxytocin nonapeptide, an autism biomarker, were designed. Embedding of the oxytocin template, and then its extracting from the molecularly imprinted polymer (MIP) was confirmed by the XPS analysis. AFM imaging of the MIP film surface indicated changes in mechanical properties of the film after template extraction. The MIP synthetic receptor was deposited by potentiodynamic electropolymerization as a thin film on an Au film electrode in an electrochemical miniaturized microfluidic cell...
September 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28934650/influence-of-human-activities-and-organic-matters-on-occurrence-of-polybrominated-diphenyl-ethers-in-marine-sediment-core-a-case-study-in-the-southern-yellow-sea-china
#6
Guoguang Wang, Lijuan Feng, Jingshuai Qi, Xianguo Li
The Southern Yellow Sea (SYS) is an important reservoir of anthropogenic organic contaminants, such as polybrominated diphenyl ethers (PBDEs). To reconstruct the historical records of PBDEs and examine their relationships with the human activities and organic matters, a(210)Pb-dated sediment core was collected from the central mud area in the SYS. The concentrations of tri-to hepta-BDEs (∑7PBDEs) and BDE-209 ranged from 9.8 to 99.8 pg g(-1) d.w. and from 12.1 to 855.4 pg g(-1) d.w., respectively, both displaying the increasing trends from the bottom to the surface...
September 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28934495/a-germline-limited-piggybac-transposase-gene-is-required-for-precise-excision-in-tetrahymena-genome-rearrangement
#7
Lifang Feng, Guangying Wang, Eileen P Hamilton, Jie Xiong, Guanxiong Yan, Kai Chen, Xiao Chen, Wen Dui, Amber Plemens, Lara Khadr, Arjune Dhanekula, Mina Juma, Hung Quang Dang, Geoffrey M Kapler, Eduardo Orias, Wei Miao, Yifan Liu
Developmentally programmed genome rearrangement accompanies differentiation of the silent germline micronucleus into the transcriptionally active somatic macronucleus in the ciliated protozoan Tetrahymena thermophila. Internal eliminated sequences (IES) are excised, followed by rejoining of MAC-destined sequences, while fragmentation occurs at conserved chromosome breakage sequences, generating macronuclear chromosomes. Some macronuclear chromosomes, referred to as non-maintained chromosomes (NMC), are lost soon after differentiation...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934379/autotrophic-biorefinery-dawn-of-the-gaseous-carbon-feedstock
#8
Sai Kishore Butti, S Venkata Mohan
CO2 is a resource yet to be effectively utilized in the autotrophic biotechnology, not only to mitigate and moderate the anthropogenic influence on our climate, but also to steer CO2 sequestration for sustainable development and carbon neutral status. The atmospheric CO2 concentration has seen an exponential increase with the turn of the new millennia causing numerous environmental issues and also in a way feedstock crisis. To progressively regulate the growing CO2 concentrations and to incorporate the integration strategies to our existing CO2 capturing tools, all the influencing factors need to be collectively considered...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28934369/in-vivo-activation-of-latent-hiv-with-a-synthetic-bryostatin-analog-effects-both-latent-cell-kick-and-kill-in-strategy-for-virus-eradication
#9
Matthew D Marsden, Brian A Loy, Xiaomeng Wu, Christina M Ramirez, Adam J Schrier, Danielle Murray, Akira Shimizu, Steven M Ryckbosch, Katherine E Near, Tae-Wook Chun, Paul A Wender, Jerome A Zack
The ability of HIV to establish a long-lived latent infection within resting CD4+ T cells leads to persistence and episodic resupply of the virus in patients treated with antiretroviral therapy (ART), thereby preventing eradication of the disease. Protein kinase C (PKC) modulators such as bryostatin 1 can activate these latently infected cells, potentially leading to their elimination by virus-mediated cytopathic effects, the host's immune response and/or therapeutic strategies targeting cells actively expressing virus...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28934186/opioid-overdose-outbreak-west-virginia-august-2016
#10
Joel Massey, Michael Kilkenny, Samantha Batdorf, Sarah K Sanders, Debra Ellison, John Halpin, R Matthew Gladden, Danae Bixler, Loretta Haddy, Rahul Gupta
On August 15, 2016, the Mayor's Office of Drug Control Policy in Huntington, West Virginia, notified the Cabell-Huntington Health Department (CHHD) of multiple calls regarding opioid overdose received by the emergency medical system (EMS) during 3 p.m.-8 p.m. that day. A public health investigation and response conducted by the West Virginia Bureau for Public Health (BPH) and CHHD identified 20 opioid overdose cases within a 53-hour period in Cabell County; all cases included emergency department (ED) encounters...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934083/outpatient-vaginal-hysterectomy-comparison-of-conventional-suture-ligature-versus-electrosurgical-bipolar-vessel-sealing
#11
G Giraudet, J P Lucot, F Sanz, C Rubod, P Collinet, M Cosson
OBJECTIVE: The aim of our study was to evaluate the feasibility of vaginal hysterectomy in an ambulatory care system and the best way to perform it between conventional and bipolar vessel sealing system ligatures. PATIENTS AND METHODS: This was a prospective study of 32 patients with vaginal hysterectomy at Lille University Hospital between December 2013 and May 2015. Two surgical techniques were compared: conventional suture ligature (CSL) and electrosurgical bipolar vessel sealing (BVS)...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28934025/tamec-a-new-analogue-of-cyclomyrsinol-diterpenes-decreases-anxiety-and-depression-like-behaviors-in-a-mouse-model-of-multiple-sclerosis
#12
Abdul Majid Ayatollahi, Mostafa Haji Molla Hoseini, Syed Mustafa Ghanadian, Morteza Kosari-Nasab, Fatemeh Mami, Zeinab Yazdiniapoure, Behzad Zolfaghari, Ali-Akbar Salari
Objectives There is a significant prevalence of affective disorders including depression and anxiety in people with multiple sclerosis (MS), resulting in reduced quality of life. Since the current treatments are not generally effective, further studies are needed to find appropriate drugs to alleviate anxiety and depression symptoms in these patients. Methods The effects of a new analog of cyclomyrsinol diterpenes (TAMEC) isolated from Euphorbia sogdiana on the anxiety (open field and elevated plus maze test) and depressive-like behaviors (sucrose preference test and forced swim test) in EAE-induced C57BL/6 mice (EAE; a mouse model of MS) were investigated...
September 21, 2017: Neurological Research
https://www.readbyqxmd.com/read/28933865/organocopper-iii-spiro-complexes-synthesis-structural-characterization-and-redox-transformation
#13
Liang Liu, Miaomiao Zhu, Hai-Tao Yu, Wen-Xiong Zhang, Zhenfeng Xi
Reductive elimination of Cu(III) intermediates is often proposed as a key step in many copper-catalyzed or -mediated formation of C‒C or C‒heteroatom bonds. However, there still lacks concrete evidence on this key step, mainly because Cu(III) complexes are usually too unstable to be isolated and structurally characterized. In this work, novel organocopper(III) spiro complexes and their analogous organocopper(I) spiro complexes were synthesized and structurally characterized. Single-crystal X-ray structural analysis revealed that the spiro Cu(III) atom adopted a distorted square-planar geometry while its corresponding spiro Cu(I) atom was tetrahedrally coordinated...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28933861/differential-effect-of-bilayer-thickness-on-sticholysin-activity
#14
Juan Palacios Ortega, Sara Garcia-Linares, Esperanza Rivera-de-Torre, Jose G Gavilanes, Alvaro Martinez-Del-Pozo, J Peter Slotte
In this study, we examined the influence of bilayer thickness on the activity of the actinoporin toxins sticholysin I and II (StnI and StnII) at 25 °C. Bilayer thickness was varied using di-monounsaturated phosphatidylcholine (PC) analogs (with 14:1, 16:1, 18:1, 20:1, and 22:1 acyl chains). In addition, N-14:0-sphingomyelin (SM) was always included because StnI and StnII are SM specific. Cholesterol was also incorporated as indicated. In cholesterol-free large unilamellar vesicles (LUV) the PC:SM molar ratio was 4:1, and when cholesterol was included, the complete molar ratio was 4:1:0...
September 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28933851/design-and-structure-guided-development-of-novel-inhibitors-of-the-xeroderma-pigmentosum-group-a-xpa-protein-dna-interaction
#15
Navnath S Gavande, Pamela VanderVere-Carozza, Akaash K Mishra, Tyler L Vernon, Katherine S Pawelczak, John J Turchi
XPA is a unique and essential protein required for the nucleotide excision DNA repair pathway and represents a therapeutic target in oncology. Herein, we are the first to develop novel inhibitors of the XPA-DNA interaction through structure-guided drug design efforts. Ester derivatives of the compounds 1 (X80), 22, and 24 displayed excellent inhibitory activity (IC50 of 0.82 ± 0.18 μM and 1.3 ± 0.22 μM, respectively) but poor solubility. We have synthesized novel amide derivatives that retain potency and have much improved solubility...
September 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28933850/an-efficient-strategy-for-the-calculation-of-solvation-free-energies-in-water-and-chloroform-at-the-quantum-mechanical-molecular-mechanical-level
#16
Meiting Wang, Pengfei Li, Xiangyu Jia, Wei Liu, Yihan Shao, Wenxin Hu, Jun Zheng, Bernard R Brooks, Ye Mei
The partitioning of solute molecules between immiscible solvents with significantly different polarities is of great importance. The polarization between the solute and solvent molecules plays an essential role in determining the solubility of the solute, which makes computational studies utilizing molecular mechanics (MM) rather difficult. In contrast, quantum mechanics (QM) can provide more reliable predictions. In this work, the partition coefficients of the side chain analogs of some amino acids between water and chloroform were computed...
September 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28933848/transfer-reagent-for-bonding-isomers-of-iron-complexes
#17
Monika Schmidt, Andreas Seitz, Maria Eckhardt, Gabor Balazs, Eugenia V Peresypkina, Alexander Virovets, Felix Riedlberger, Michael Bodensteiner, Eva M Zolnhofer, Karsten Meyer, Manfred Scheer
The co-thermolysis of As4 and [Cp''2Zr(CO)2] (Cp'' = η5-C5H3tBu2) results in the formation of [Cp''2Zr(η1:1-As4)] (1) in high yields and the arsenic-rich complex [(Cp''2Zr)(Cp''Zr)(µ,η2:2:1-As5)] (2) as a minor product. In contrast to yellow arsenic, 1 is a light-stable, weighable and storable arsenic source for subsequent reactions. This is demonstrated by the transfer reaction of the As42- unit under mild conditions. The reaction of 1 with [Cp'''Fe(µ-Br)]2 (Cp''' = η5-C5H2tBu3) yields the unprecedented bond isomeric complexes [(Cp'''Fe)2(μ,η4:4-As4)] (3a) and [(Cp'''Fe)2(μ,η4:4-cyclo-As4)] (3b)...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28933846/inhibition-of-calcium-dependent-protein-kinase-1-cdpk1-by-pyrazolopyrimidine-analogs-decreases-establishment-and-reoccurrence-of-central-nervous-system-disease-by-toxoplasma-gondii
#18
Florentine U Rutaganira, Jennifer Barks, Mary Savari Dhason, Qiuling Wang, Michael Steven Lopez, Shaojun Long, Joshua B Radke, Nathaniel G Jones, Amarendar R Maddirala, James W Janetka, Majida El Bakkouri, Raymond Hui, Kevan M Shokat, L David Sibley
Calcium dependent protein kinase 1 (CDPK1) is an essential enzyme in the opportunistic pathogen Toxoplasma gondii. CDPK1 controls multiple processes that are essential to the intracellular replicative cycle of T. gondii including secretion of adhesins, motility, invasion, and egress. Remarkably, CDPK1 contains a small glycine gatekeeper residue in the ATP binding pocket making it sensitive to ATP-competitive inhibitors with bulky substituents that complement this expanded binding pocket. Here we explored structure-activity relationships of a series of pyrazolopyrimidine inhibitors of CDPK1 with the goals of increasing selectivity over host enzymes, improving anti-parasite potency, and improving metabolic stability...
September 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28933840/divergent-synthesis-of-revised-apratoxin-e-30-epi-apratoxin-e-and-30s-30r-oxoapratoxin-e
#19
Zhuo-Ya Mao, Chang-Mei Si, Yi-Wen Liu, Han-Qing Dong, Bang-Guo Wei, Guo-Qiang Lin
In this report, originally proposed apratoxin E (30S-7), revised apratoxin E (30R-7), and (30S)/(30R)-oxoapratoxin E (30S)-38/(30R)-38 were efficiently prepared by two synthetic methods. The chiral lactone 10, recycled from the degradation of saponin glycosides, was utilized to prepare the key non-peptide fragment 9. Our alternative convergent assembly strategy was applied to the divergent synthesis of revised apratoxin E and its three analogs. Moreover, ring-closing metathesis (RCM) was first time found to be an efficient strategy for the macrocyclization of apratoxins...
September 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28933832/detoxification-of-atrazine-by-low-molecular-weight-thiols-in-alfalfa-medicago-sativa
#20
Jing Jing Zhang, Jiang-Yan Xu, Feng Fan Lu, She Feng Jin, Hong Yang
Low molecular weight (LMW) thiols in higher plants are a group of sulfur-rich non-protein compounds and play primary and multiple roles in cellular redox homeostasis, enzyme activities, and xenobiotics detoxification. This study focused on identifying thiols-related protein genes from the legume alfalfa exposed to the herbicide atrazine (ATZ) residues in environment. Using high-throughput RNA-sequencing, a set of ATZ-responsive thiols-related protein genes highly up-regulated and differentially expressed in alfalfa were identified...
September 21, 2017: Chemical Research in Toxicology
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