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https://www.readbyqxmd.com/read/28651305/effects-of-entecavir-and-tenofovir-on-renal-function-in-patients-with-hepatitis-b-virus-related-compensated-and-decompensated-cirrhosis
#1
Jihye Park, Kyu Sik Jung, Hye Won Lee, Beom Kyung Kim, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jun Yong Park
Background/Aims: The renal effects of nucleos(t)ide analogs in patients with chronic hepatitis B are controversial. We aimed to compare the impact of entecavir (ETV) and tenofovir (TDF) on renal function in patients with hepatitis B virus (HBV)-related cirrhosis. Methods: We performed a retrospective cohort study of 235 consecutive treatment-naïve patients with HBV-related cirrhosis who were treated with ETV or TDF between December 2012 and November 2013 at Severance Hospital, Seoul, Korea...
June 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28651257/angles-traction-and-time-after-delivery-of-fetal-head-interobserver-variation-of-novel-visual-analogs
#2
Nana-Ama E Ankumah, Vidya B Chauhan, Claudia Pedroza, Rodney M McLaren, Sean C Blackwell, Suneet P Chauhan
No abstract text is available yet for this article.
June 26, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28651091/loggerhead-sea-turtles-caretta-caretta-a-target-species-for-monitoring-litter-ingested-by-marine-organisms-in-the-mediterranean-sea
#3
Marco Matiddi, Sandra Hochsheid, Andrea Camedda, Matteo Baini, Cristiano Cocumelli, Fabrizio Serena, Paolo Tomassetti, Andrea Travaglini, Stefano Marra, Tommaso Campani, Francesco Scholl, Cecilia Mancusi, Ezio Amato, Paolo Briguglio, Fulvio Maffucci, Maria Cristina Fossi, Flegra Bentivegna, Giuseppe Andrea de Lucia
Marine litter is any persistent, manufactured or processed solid material discarded, disposed of or abandoned in the marine and coastal environment. Ingestion of marine litter can have lethal and sub-lethal effects on wildlife that accidentally ingests it, and sea turtles are particularly susceptible to this threat. The European Commission drafted the 2008/56/EC Marine Strategy Framework Directive with the aim to achieve a Good Environmental Status (GES), and the loggerhead sea turtle (Caretta caretta, Linnaeus 1758) was selected for monitoring the amount and composition of litter ingested by marine animals...
June 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28650956/in-vitro-and-in-vivo-effects-of-kisspeptin-antagonists-p234-p271-p354-and-p356-on-gpr54-activation
#4
C H J Albers-Wolthers, J de Gier, M Walen, P J S van Kooten, C B Lambalk, P A J Leegwater, B A J Roelen, A C Schaefers-Okkens, V P M G Rutten, R P M Millar, H S Kooistra
Kisspeptins (KPs) and their receptor (GPR54 or KiSS1R) play a key-role in regulation of the hypothalamic-pituitary-gonadal axis and are therefore interesting targets for therapeutic interventions in the field of reproductive endocrinology. As dogs show a rapid and robust LH response after the administration of KP10, they can serve as a good animal model for research concerning KP signaling. The aims of the present study were to test the antagonistic properties of KP analogs p234, p271, p354, and p356 in vitro, by determining the intracellular Ca2+ response of CHEM1 cells that stably express human GPR54, and to study the in vivo effects of these peptides on basal plasma LH concentration and the KP10-induced LH response in female dogs...
2017: PloS One
https://www.readbyqxmd.com/read/28650880/downward-laminotomy-technique-for-hidden-zone-foraminal-disk-herniations-technical-notes-and-preliminary-results
#5
Sait Naderi, Mehmet R Onen
INTRODUCTION: Hidden zone foraminal herniations are among the more rare forms of herniations. As exploration is difficult, and there is a close relationship between the nerve root and pedicle, many surgical approaches have been proposed. The aim of this study was to describe downward laminotomy as a new approach to these herniations. MATERIALS AND METHODS: A downward laminotomy technique was used in 5 cases with hidden zone foraminal disk herniation with no extension to the intervertebral disk space...
June 23, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28650749/comparative-effectiveness-of-radial-extracorporeal-shockwave-therapy-and-ultrasound-guided-local-corticosteroid-injection-treatment-for-plantar-fasciitis
#6
Sehriban Hocaoglu, Umit Erkan Vurdem, Mehtap Aykac Cebicci, Serap Tomruk Sutbeyaz, Zuhal Guldeste, Serap Gurek Yunsuroglu
BACKGROUND: We compared the long-term clinical and ultrasonographic effects of radial extracorporeal shockwave therapy (rESWT) versus ultrasound-guided corticosteroid injection treatment in patients with plantar fasciitis unresponsive to conservative therapy. METHODS: Seventy-two patients with unilateral plantar fasciitis were randomized to receive either rESWT (three times once per week) (n = 36) or corticosteroid treatment (a single 1-mL dose of betamethasone sodium plus 0...
May 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28650628/synthesis-and-evaluation-of-new-fluorine-18-labeled-verapamil-analogs-to-investigate-the-function-of-p-glycoprotein-in-the-blood-brain-barrier
#7
Renske Maria Raaphorst, Gert Luurtsema, Robert C Schuit, Esther J M Kooijman, Philip H Elsinga, Adriaan A Lammertsma, Albert D Windhorst
P-glycoprotein is an efflux transporter located in the blood-brain barrier. (R)-[(11)C]verapamil is widely used as a PET tracer to investigate its function in patients with epilepsy, Alzheimer's disease and other neurodegenerative diseases. Currently it is not possible to use this successful tracer in clinics without a cyclotron, because of the short half-life of carbon-11. We developed two new fluorine-18 labeled (R)-verapamil analogs, with the benefit of a longer half-life. The synthesis of (R)-N-[(18)F]fluoroethylverapamil ([(18)F]1) and (R)-O-[(18)F]fluoroethylnorverapamil ([(18)F]2), has been described...
June 26, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28650559/the-antibacterial-activity-and-modes-of-li-f-type-antimicrobial-peptides-against-bacillus-cereus-in-vitro
#8
Jinzhi Han, Shengming Zhao, Zhi Ma, Ling Gao, Hongxia Liu, Umair Muhammad, Zhaoxin Lu, Fengxia Lv, Xiaomei Bie
AIMS: LI-Fs are a family of highly potent cyclic lipodepsipeptide antibiotics with a broad antimicrobial spectrum (Gram-positive bacteria and fungi). In this study, LI-F type antimicrobial peptides (AMP-jsa9) composing of LI-F03a, LI-F03b, LI-F04a, LI-F04b, and LI-F05b were isolated from Paenibacillus polymyxa JSA-9. To better understand the antimicrobial mechanism of AMP-jsa9, the potency and action(s) of AMP-jsa9 against B. cereus were examined. METHODS AND RESULTS: Flow cytometry, confocal laser microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM) observation, as well as determination of peptidoglycan and cell wall associated protein, and other methods were used...
June 26, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28650176/the-role-of-through-space-interactions-in-modulating-constructive-and-destructive-interference-effects-in-benzene
#9
Anders Borges, Jianlong Xia, Sheng-Hua Liu, Latha Venkataraman, Gemma C Solomon
Quantum interference effects, be they constructive or destructive, are key to predicting and understanding the electrical conductance of single molecules. Here, through theory and experiment, we investigate a family of benzene-like molecules that exhibit both constructive and destructive interference effects arising due to more than one contact between the molecule and each electrode. In particular, we demonstrate that the π-system of meta-coupled benzene can exhibit constructive interference and its para-coupled analog can exhibit destructive interference - and vice versa - depending on the specific through-space interactions...
June 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28650175/bioactive-peptide-natural-products-as-lead-structures-for-medicinal-use
#10
Tam Dang, Roderich D Süssmuth
The need for new drugs for the treatment of various diseases is enormous. From the previous century until the present, numerous peptide and peptide-derived natural products have been isolated from bacteria and fungi. Hence, microorganisms play a pivotal role as sources for novel drugs with an emphasis on anti-infective agents. Various disciplines from biology, chemistry, and medicine are involved in early stages of the search for peptide natural products including taxonomy, microbiology, bioanalytics, bioinformatics, and medicinal chemistry...
June 26, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28649853/cationic-liposome-co-encapsulation-of-smac-mimetic-and-zvad-using-a-novel-lipid-bilayer-fusion-loaded-with-mlkl-pdna-for-tumor-inhibition-in-vivo
#11
Dan Sun, Linshu Zhao, Junzhong Lin, Yun Zhao, Yu Zheng
The increase in multidrug resistance among colon cancer cells presents a challenge for the development of effective therapies. Small-molecule analogs of second mitochondria-derived activator of caspase (SMAC) mimetic in association with mixed lineage kinase domain-like protein (MLKL)-pDNA and z-VAD-fmk have shown ideal antitumor effects in colon cancer cells in vitro via induction of RIP3-dependent necroptosis. To achieve synergistic antitumor effects in vivo, liposomes loaded with SMAC mimetic, MLKL-pDNA and z-VAD-fmk have been developed using novel lipid fusion methods to co-localize the molecules of interest within the tumor cells...
June 26, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28649789/beyond-mitf-multiple-transcription-factors-directly-regulate-the-cellular-phenotype-in-melanocytes-and-melanoma
#12
REVIEW
Hannah E Seberg, Eric Van Otterloo, Robert A Cornell
MITF governs multiple steps in the development of melanocytes, including specification from neural crest, growth, survival, and terminal differentiation. In addition, the level of MITF activity determines the phenotype adopted by melanoma cells, whether invasive, proliferative, or differentiated. However, MITF does not act alone. Here we review literature on the transcription factors that co-regulate MITF-dependent genes. ChIP-seq studies have indicated that the transcription factors SOX10, YY1, and TFAP2A co-occupy subsets of regulatory elements bound by MITF in melanocytes...
June 26, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28649754/characterization-and-differentiation-of-geometric-isomers-of-3-methylfentanyl-analogs-by-gas-chromatography-mass-spectrometry-liquid-chromatography-mass-spectrometry-and-nuclear-magnetic-resonance-spectroscopy
#13
Tatsuyuki Kanamori, Yuko T Iwata, Hiroki Segawa, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Hiroyuki Inoue
The cis and trans isomers of 3-methylfentanyl and its three analogs were chemically synthesized, and these compounds were characterized and differentiated by gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), and nuclear magnetic resonance (NMR) spectroscopy. The cis and trans isomers of the 3-methylfentanyl analogs were completely separated by GC/MS. Although the high temperature of the GC injection port caused thermal degradation of β-hydroxy-3-methylfentanyl, the degradation was completely suppressed by trimethylsilyl derivatization...
June 26, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28649696/amaryllidaceae-alkaloids-absolute-configuration-and-biological-activity
#14
REVIEW
Alessio Cimmino, Marco Masi, Marco Evidente, Stefano Superchi, Antonio Evidente
Plants belonging to the Amaryllidaceae family are well known for their ornamental and medicinal use. Plant members of this group are distributed through both tropical and subtropical regions of the world and are dominant in Andean South America, the Mediterranean basin, and southern Africa. Amaryllidaceae plants have been demonstrated to be a good source of alkaloids with a large spectrum of biological activities, the latter being strictly related to the absolute stereochemistry of the alkaloid scaffold. Among them, great importance for practical applications in medicine has galanthamine, which has already spawned an Alzheimer's prescription drug as a potent and selective inhibitor of the enzyme acetylcholinesterase...
June 26, 2017: Chirality
https://www.readbyqxmd.com/read/28649650/vitamin-d-ointment-for-prevention-of-radiation-dermatitis-in-breast-cancer-patients
#15
Nicola J Nasser, Shlomit Fenig, Amiram Ravid, Ariella Nouriel, Naama Ozery, Sara Gardyn, Ruth Koren, Eyal Fenig
Radiation dermatitis occurs frequently during adjuvant radiation therapy for breast cancer. Prevention of radiation dermatitis by applying various creams and ointments has a limited success, and Aqua cream which has urea as one of its active ingredients is used in many institutions as a preventive treatment. The primary goal of this study is to assess the effect of vitamin D (calcipotriol) ointment in prevention of radiodermatitis in breast cancer patients compared to Aqua cream. Twenty-three women with localized breast cancer who underwent breast-conserving surgery and opted to receive adjuvant radiotherapy to breast only were enrolled in this study...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28649636/interplay-of-space-radiation-and-microgravity-in-dna-damage-and-dna-damage-response
#16
María Moreno-Villanueva, Michael Wong, Tao Lu, Ye Zhang, Honglu Wu
In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms. Specifically, space radiation can cause damage to DNA directly, through the interaction of charged particles with the DNA molecules themselves, or indirectly through the production of free radicals. Although organisms have evolved strategies on Earth to confront such damage, space environmental conditions, especially microgravity, can impact DNA repair resulting in accumulation of severe DNA lesions...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649630/towards-human-exploration-of-space-the-theseus-review-series-on-muscle-and-bone-research-priorities
#17
Thomas Lang, Jack J W A Van Loon, Susan Bloomfield, Laurence Vico, Angele Chopard, Joern Rittweger, Antonios Kyparos, Dieter Blottner, Ilkka Vuori, Rupert Gerzer, Peter R Cavanagh
Without effective countermeasures, the musculoskeletal system is altered by the microgravity environment of long-duration spaceflight, resulting in atrophy of bone and muscle tissue, as well as in deficits in the function of cartilage, tendons, and vertebral disks. While inflight countermeasures implemented on the International Space Station have evidenced reduction of bone and muscle loss on low-Earth orbit missions of several months in length, important knowledge gaps must be addressed in order to develop effective strategies for managing human musculoskeletal health on exploration class missions well beyond Earth orbit...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649626/investigation-of-simulated-microgravity-effects-on-streptococcus-mutans-physiology-and-global-gene-expression
#18
Silvia S Orsini, April M Lewis, Kelly C Rice
Astronauts have been previously shown to exhibit decreased salivary lysozyme and increased dental calculus and gingival inflammation in response to space flight, host factors that could contribute to oral diseases such as caries and periodontitis. However, the specific physiological response of caries-causing bacteria such as Streptococcus mutans to space flight and/or ground-based simulated microgravity has not been extensively investigated. In this study, high aspect ratio vessel S. mutans simulated microgravity and normal gravity cultures were assessed for changes in metabolite and transcriptome profiles, H2O2 resistance, and competence in sucrose-containing biofilm media...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649078/3-4-chlorophenyl-1-2-3-oxadiazol-3-ium-5-olate-and-its-4-formyl-analog-ultrasound-assisted-synthesis-and-in-vitro-anticancer-evaluation-against-human-tumor-cell-lines
#19
Sachin K Bhosale, Shreenivas R Deshpande, Rajendra D Wagh
The title compound, 3-(4-chlorophenyl)-4-formyl-[1, 2, 3] oxadiazol-3-ium-5-olate 5 was synthesized under ultrasonication by formylation of 3-(4-chlorophenyl)-[1, 2, 3] oxadiazol-3-ium-5-olate 4 and characterized by spectral studies. The ultrasonic method of synthesis was found to be simple, ecofriendly, economical, reduces reaction time and gave good yield when compared with traditional methods of synthesis. Anticancer activity of the compounds were tested against 60 human tumor cell lines and compared with standard drug vincristine sulphate...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28648934/molecular-alterations-in-lesions-of-anogenital-mammary-like-glands-and-their-mammary-counterparts-including-hidradenoma-papilliferum-intraductal-papilloma-fibroadenoma-and-phyllodes-tumor
#20
Anastasia M Konstantinova, Tomas Vanecek, Petr Martinek, Liubov Kyrpychova, Dominic V Spagnolo, Colin J R Stewart, Francesca Portelli, Michal Michal, Dmitry V Kazakov
Lesions affecting anogenital mammary-like glands (AGMLG) are histopathologically very similar to those seen in the breast but whether this morphological similarity is also reflected at the genetic level is unknown. To compare the underlying molecular mechanisms in lesions of AGMLG and their mammary counterparts, we analyzed the mutational profile of 16 anogenital neoplasms including 5 hidradenomas papilliferum (HP), 1 lesion with features of HP and fibroadenoma (FA), 7 FA, 3 phyllodes tumors (PhT)) and 18 analogous breast lesions (6 intraductal papillomas (IDP), 9 FA, and 3 PhT) by high-coverage next generation sequencing (NGS) using a panel comprising 50 cancer-related genes...
June 2017: Annals of Diagnostic Pathology
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