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https://www.readbyqxmd.com/read/29771234/an-observational-clinical-case-of-zika-virus-associated-neurological-disease-is-associated-with-primary-igg-response-and-enhanced-tnf-levels
#1
Edson Delatorre, Milene Miranda, Diogo A Tschoeke, Patrícia Carvalho de Sequeira, Simone Alves Sampaio, Giselle Barbosa-Lima, Yasmine Rangel Vieira, Luciana Leomil, Fernando A Bozza, José Cerbino-Neto, Patricia T Bozza, Rita Maria Ribeiro Nogueira, Patrícia Brasil, Fabiano L Thompson, Ana M B de Filippis, Thiago Moreno L Souza
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine)...
May 17, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29763445/pyrethroid-insecticides-maintain-repellent-effect-on-knock-down-resistant-populations-of-aedes-aegypti-mosquitoes
#2
Natalie M Bowman, Kristin Akialis, Grayson Cave, Roberto Barrera, Charles S Apperson, Steven R Meshnick
Pyrethroid-treated clothing is commonly worn for protection against mosquitoes; pyrethroids are both insecticides and repellents. Pyrethroid resistance has become increasingly common in Aedes aegypti, the vector of dengue, Zika, and other arboviruses, but it is not clear whether resistance is associated with reductions in repellency. In order to determine whether long-lasting permethrin impregnated (LLPI) clothing is protective, we used Aedes aegypti from New Orleans, LA (pyrethroid-sensitive) and San Juan, PR (resistant) to measure both lethality and repellency...
2018: PloS One
https://www.readbyqxmd.com/read/29746833/rational-engineering-and-characterization-of-an-mab-that-neutralizes-zika-virus-by-targeting-a-mutationally-constrained-quaternary-epitope
#3
Kannan Tharakaraman, Satoru Watanabe, Kuan Rong Chan, Jia Huan, Vidya Subramanian, Yok Hian Chionh, Aditya Raguram, Devin Quinlan, Megan McBee, Eugenia Z Ong, Esther S Gan, Hwee Cheng Tan, Anu Tyagi, Shashi Bhushan, Julien Lescar, Subhash G Vasudevan, Eng Eong Ooi, Ram Sasisekharan
Following the recent emergence of Zika virus (ZIKV), many murine and human neutralizing anti-ZIKV antibodies have been reported. Given the risk of virus escape mutants, engineering antibodies that target mutationally constrained epitopes with therapeutically relevant potencies can be valuable for combating future outbreaks. Here, we applied computational methods to engineer an antibody, ZAb_FLEP, that targets a highly networked and therefore mutationally constrained surface formed by the envelope protein dimer...
May 9, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29745863/generation-and-comparative-genomics-of-synthetic-dengue-viruses
#4
Eli Goz, Yael Tsalenchuck, Rony Oren Benaroya, Zohar Zafrir, Shimshi Atar, Tahel Altman, Justin Julander, Tamir Tuller
BACKGROUND: Synthetic virology is an important multidisciplinary scientific field, with emerging applications in biotechnology and medicine, aiming at developing methods to generate and engineer synthetic viruses. In particular, many of the RNA viruses, including among others the Dengue and Zika, are widespread pathogens of significant importance to human health. The ability to design and synthesize such viruses may contribute to exploring novel approaches for developing vaccines and virus based therapies...
May 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29728911/nanoparticle-vaccines-against-viral-infections
#5
REVIEW
Fernando B Sulczewski, Raquel B Liszbinski, Pedro R T Romão, Luiz Carlos Rodrigues Junior
Despite numerous efforts, we still do not have prophylactic vaccines for many clinically relevant viruses, such as HIV, hepatitis C virus, Zika virus, and respiratory syncytial virus. Several factors have contributed to the current lack of effective vaccines, including the high rate of viral mutation, low immunogenicity of recombinant viral antigens, instability of viral antigenic proteins administered in vivo, sophisticated mechanisms of viral immune evasion, and inefficient induction of mucosal immunity by vaccine models studied to date...
May 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29712956/parallel-evolution-of-vgsc-mutations-at-domains-is6-iis6-and-iiis6-in-pyrethroid-resistant-aedes-aegypti-from-mexico
#6
Karla Saavedra-Rodriguez, Farah Vera Maloof, Corey L Campbell, Julian Garcia-Rejon, Audrey Lenhart, Patricia Penilla, Americo Rodriguez, Arturo Acero Sandoval, Adriana E Flores, Gustavo Ponce, Saul Lozano, William C Black
Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers -for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid space-sprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc)...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691387/fetal-demise-and-failed-antibody-therapy-during-zika-virus-infection-of-pregnant-macaques
#7
Diogo M Magnani, Thomas F Rogers, Nicholas J Maness, Nathan D Grubaugh, Nathan Beutler, Varian K Bailey, Lucas Gonzalez-Nieto, Martin J Gutman, Núria Pedreño-Lopez, Jaclyn M Kwal, Michael J Ricciardi, Tereance A Myers, Justin G Julander, Rudolf P Bohm, Margaret H Gilbert, Faith Schiro, Pyone P Aye, Robert V Blair, Mauricio A Martins, Kathrine P Falkenstein, Amitinder Kaur, Christine L Curry, Esper G Kallas, Ronald C Desrosiers, Pascal J Goldschmidt-Clermont, Stephen S Whitehead, Kristian G Andersen, Myrna C Bonaldo, Andrew A Lackner, Antonito T Panganiban, Dennis R Burton, David I Watkins
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29601580/pyrethroid-resistance-persists-after-ten-years-without-usage-against-aedes-aegypti-in-governmental-campaigns-lessons-from-s%C3%A3-o-paulo-state-brazil
#8
Maria de Lourdes Macoris, Ademir Jesus Martins, Maria Teresa Macoris Andrighetti, José Bento Pereira Lima, Denise Valle
BACKGROUND: Aedes aegypti, vector of dengue, chikungunya and Zika viruses, is found at high densities in tropical urban areas. The dissemination of this vector is partially the consequence of failures in current vector control methods, still mainly relying upon insecticides. In the State of São Paulo (SP), Brazil, public health managers employed pyrethroids against Ae. aegypti adults from 1989 to 2000, when a robust insecticide resistance monitoring system detected resistance to pyrethroids in several Ae...
March 30, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29575404/frequency-and-intensity-of-pyrethroid-resistance-through-the-cdc-bottle-bioassay-and-their-association-with-the-frequency-of-kdr-mutations-in-aedes-aegypti-diptera-culicidae-from-mexico
#9
Beatriz Lopez-Monroy, Selene M Gutierrez-Rodriguez, O Karina Villanueva-Segura, Gustavo Ponce-Garcia, Franco Morales-Forcada, Leslie C Alvarez, Adriana E Flores
BACKGROUND: The control of Aedes aegypti (L.), the main urban vector that causes arboviral diseases such as dengue, Chikungunya, and Zika, has proved to be a challenge due to a rapid increase in insecticide resistance. Therefore, the adequate monitoring of insecticide resistance is an essential element for the control of Ae. aegypti and the diseases it transmits. We estimated the frequency and intensity (F-RDT and I-RDT) of pyrethroid resistance in populations of Ae. aegypti from Mexico using the bottle bioassay and results were related to the frequencies of kdr mutations V1016I and F1534C...
March 25, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29449508/multiplexed-and-portable-nucleic-acid-detection-platform-with-cas13-cas12a-and-csm6
#10
Jonathan S Gootenberg, Omar O Abudayyeh, Max J Kellner, Julia Joung, James J Collins, Feng Zhang
Rapid detection of nucleic acids is integral for clinical diagnostics and biotechnological applications. We recently developed a platform termed SHERLOCK (specific high-sensitivity enzymatic reporter unlocking) that combines isothermal preamplification with Cas13 to detect single molecules of RNA or DNA. Through characterization of CRISPR enzymology and application development, we report here four advances integrated into SHERLOCK version 2 (SHERLOCKv2) (i) four-channel single-reaction multiplexing with orthogonal CRISPR enzymes; (ii) quantitative measurement of input as low as 2 attomolar; (iii) 3...
April 27, 2018: Science
https://www.readbyqxmd.com/read/29428601/codon-usage-variation-of-zika-virus-the-potential-roles-of-ns2b-and-ns4a-in-its-global-pandemic
#11
Dechun Lin, Liqiang Li, Tian Xie, Qingqing Yin, Nitin Saksena, Rangke Wu, Wanyu Li, Geyang Dai, Jinmin Ma, Xiaohong Zhou, Xiaoguang Chen
A comprehensive demonstration of Zika virus (ZIKV) molecular evolution is essential for understanding its adaptation and expansion in its recent pandemics. Despite several studies on mutations and codon usage in ZIKVs, the variations in codon usage patterns across individual genes and their biological implication remains unclear. Here, we performed a gene-by-gene comparison of the codon usage variation in ZIKVs of the African and Asian lineages. We found that besides the evidence of positive selection (Ka/Ks >1) in the Asian lineage of the ZIKV genome, codon usage patterns were gene-specific and codon usage variation of ZIKV genes, was possibly constrained by their individual functional features, such as transmembrane domains, or antigenicity...
March 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29427798/evidence-for-multiple-sylvatic-transmission-cycles-during-the-2016-2017-yellow-fever-virus-outbreak-brazil
#12
A Moreira-Soto, M C Torres, M C Lima de Mendonça, M A Mares-Guia, C D Dos Santos Rodrigues, A A Fabri, C C Dos Santos, E S Machado Araújo, C Fischer, R M Ribeiro Nogueira, C Drosten, P Carvalho Sequeira, J F Drexler, A M Bispo de Filippis
OBJECTIVES: Since December 2016, Brazil has experienced an unusually large outbreak of yellow fever (YF). Whether urban transmission may contribute to the extent of the outbreak is unclear. The objective of this study was to characterize YF virus (YFV) genomes and to identify spatial patterns to determine the distribution and origin of YF cases in Minas Gerais, Espírito Santo and Rio de Janeiro, the most affected Brazilian states during the current YFV outbreak. METHODS: We characterized near-complete YFV genomes from 14 human cases and two nonhuman primates (NHP), sampled from February to April 2017, retrieved epidemiologic data of cases and used a geographic information system to investigate the geospatial spread of YFV...
February 7, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29379028/an-evolutionary-ns1-mutation-enhances-zika-virus-evasion-of-host-interferon-induction
#13
Hongjie Xia, Huanle Luo, Chao Shan, Antonio E Muruato, Bruno T D Nunes, Daniele B A Medeiros, Jing Zou, Xuping Xie, Maria Isabel Giraldo, Pedro F C Vasconcelos, Scott C Weaver, Tian Wang, Ricardo Rajsbaum, Pei-Yong Shi
Virus-host interactions determine an infection outcome. The Asian lineage of Zika virus (ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after 2012 that enhances mosquito infection. Here we report that the same mutation confers NS1 to inhibit interferon-β induction. This mutation enables NS1 binding to TBK1 and reduces TBK1 phosphorylation. Engineering the mutation into a pre-epidemic ZIKV strain debilitates the virus for interferon-β induction; reversing the mutation in an epidemic ZIKV strain invigorates the virus for interferon-β induction; these mutational effects are lost in IRF3-knockout cells...
January 29, 2018: Nature Communications
https://www.readbyqxmd.com/read/29355007/potential-mechanisms-for-enhanced-zika-epidemic-and-disease
#14
Hongjie Xia, Xuping Xie, Chao Shan, Pei-Yong Shi
A number of mechanisms have driven the explosive epidemics and severe diseases of Zika virus since 2007. Here, we comment on how herd immunity, heterologous flavivirus preimmunity, and viral mutations could enhance the epidemic potential and disease severity of Zika virus in humans.
January 22, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29329394/analysis-of-the-aedes-albopictus-c6-36-genome-provides-insight-into-cell-line-utility-for-viral-propagation
#15
Jason R Miller, Sergey Koren, Kari A Dilley, Vinita Puri, David M Brown, Derek M Harkins, Françoise Thibaud-Nissen, Benjamin Rosen, Xiao-Guang Chen, Zhijian Tu, Igor V Sharakhov, Maria V Sharakhova, Robert Sebra, Timothy B Stockwell, Nicholas H Bergman, Granger G Sutton, Adam M Phillippy, Peter M Piermarini, Reed S Shabman
Background: The 50-year-old Aedes albopictus C6/36 cell line is a resource for the detection, amplification, and analysis of mosquito-borne viruses including Zika, dengue, and chikungunya. The cell line is derived from an unknown number of larvae from an unspecified strain of Aedes albopictus mosquitoes. Toward improved utility of the cell line for research in virus transmission, we present an annotated assembly of the C6/36 genome. Results: The C6/36 genome assembly has the largest contig N50 (3...
March 1, 2018: GigaScience
https://www.readbyqxmd.com/read/29298700/evidence-for-multiple-insecticide-resistance-in-urban-aedes-albopictus-populations-in-southern-china
#16
Yiji Li, Jiabao Xu, Daibin Zhong, Hong Zhang, Wenqiang Yang, Guofa Zhou, Xinghua Su, Yang Wu, Kun Wu, Songwu Cai, Guiyun Yan, Xiao-Guang Chen
BACKGROUND: Aedes albopictus (Skuse) is an invasive mosquito that has become an important vector of chikungunya, dengue and Zika viruses. In the absence of specific antiviral therapy or a vaccine, vector management is the sole method available for reducing Aedes-induced disease morbidity. Determining the resistance status of Ae. albopictus to insecticides and exploring the resistance mechanisms is essential for future vector control planning. METHODS: Aedes albopictus larvae and pupae were sampled from six sites (two sites each from urban, suburban and rural) in Guangzhou...
January 3, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29297281/suggested-mechanisms-for-zika-virus-causing-microcephaly-what-do-the-genomes-tell-us
#17
Se-Ran Jun, Trudy M Wassenaar, Visanu Wanchai, Preecha Patumcharoenpol, Intawat Nookaew, David W Ussery
BACKGROUND: Zika virus (ZIKV) is an emerging human pathogen. Since its arrival in the Western hemisphere, from Africa via Asia, it has become a serious threat to pregnant women, causing microcephaly and other neuropathies in developing fetuses. The mechanisms behind these teratogenic effects are unknown, although epidemiological evidence suggests that microcephaly is not associated with the original, African lineage of ZIKV. The sequences of 196 published ZIKV genomes were used to assess whether recently proposed mechanistic explanations for microcephaly are supported by molecular level changes that may have increased its virulence since the virus left Africa...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29279447/isolation-and-complete-genome-sequencing-of-zika-virus-imported-from-the-dominican-republic-to-japan
#18
Hiroki Ozawa, Shigeru Tajima, Eri Nakayama, Kengo Kato, Akifumi Yamashita, Tsuyoshi Sekizuka, Makoto Kuroda, Shuzo Usuku
Zika virus (ZIKV) infection has been documented within Central and South America, Asia, and Africa. Here we report the isolation of virus from a patient infected with ZIKV returning to Japan from the Dominican Republic. The ZIKV strain was imaged by electron microscopy and its complete genome sequence was analyzed. Phylogenetic analysis and molecular characterization revealed that the strain was of Asian lineage, and carried 2 unique mutations in its NS5 region. These mutations are characteristic of strains that originated in the Dominican Republic and the USA in 2016...
January 23, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29226326/retreg1-fam134b-a-new-player-in-human-diseases-15-years-after-the-discovery-in-cancer
#19
REVIEW
Farhadul Islam, Vinod Gopalan, Alfred King-Yin Lam
FAM134B (family with sequence similarity 134, member B)/RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional expression of FAM134B protein impairs ER-turnover and thereby is involved in the pathogenesis of some human diseases...
June 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29212937/experimental-adaptive-evolution-of-simian-immunodeficiency-virus-sivcpz-to-pandemic-human-immunodeficiency-virus-type-1-by-using-a-humanized-mouse-model
#20
Kei Sato, Naoko Misawa, Junko S Takeuchi, Tomoko Kobayashi, Taisuke Izumi, Hirofumi Aso, Shumpei Nagaoka, Keisuke Yamamoto, Izumi Kimura, Yoriyuki Konno, Yusuke Nakano, Yoshio Koyanagi
Human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, originated from simian immunodeficiency virus from chimpanzees (SIVcpz), the precursor of the human virus, approximately 100 years ago. This indicates that HIV-1 has emerged through the cross-species transmission of SIVcpz from chimpanzees to humans. However, it remains unclear how SIVcpz has evolved into pandemic HIV-1 in humans. To address this question, we inoculated three SIVcpz strains (MB897, EK505, and MT145), four pandemic HIV-1 strains (NL4-3, NLCSFV3, JRCSF, and AD8), and two nonpandemic HIV-1 strains (YBF30 and DJO0131)...
February 15, 2018: Journal of Virology
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