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https://www.readbyqxmd.com/read/29142521/fatal-infections-in-older-patients-with-inflammatory-bowel-disease-on-anti-tumor-necrosis-factor-therapy
#1
Way-Seah Lee, Najib Azmi, Ruey-Terng Ng, Sik-Yong Ong, Sasheela Sri La Ponnampalavanar, Sanjiv Mahadeva, Ida Hilmi
Anti-tumor necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD); however, it is associated with an increased risk of infections, particularly in older adults. We reviewed 349 patients with IBD, who were observed over a 12-month period, 74 of whom had received anti-TNF therapy (71 patients were aged <60 years and 3 were aged ≥60 years). All the 3 older patients developed serious infectious complications after receiving anti-TNFs, although all of them were also on concomitant immunosuppressive therapy...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29142435/characterization-of-the-phenolic-compound-gallic-acid-from-sansevieria-roxburghiana-schult-and-schult-f-rhizomes-and-antioxidant-and-cytotoxic-activities-evaluation
#2
Rajalekshmi Maheshwari, Chandrashekara Shastry Shreedhara, Picheswara Rao Polu, Renuka Suresh Managuli, Seena Kanniparambil Xavier, Richard Lobo, Manjunath Setty, Srinivas Mutalik
Background: Sansevieria roxburghiana Schult. and Schult. f. (Asparagaceae) grows in India, Indonesia, Sri Lanka, and tropical Africa. Even though the plant has been traditionally used for the treatment of many ailments, the antioxidant and antiproliferative activities of S. roxburghiana methanol extract and its fractions have not yet been explored. Materials and Methods: Quantitative estimation of phenols and different antioxidant assays were performed using standard methods...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142404/chalepin-a-compound-from-ruta-angustifolia-l-pers-exhibits-cell-cycle-arrest-at-s-phase-suppresses-nuclear-factor-kappa-b-nf-%C3%AE%C2%BAb-pathway-signal-transducer-and-activation-of-transcription-3-stat3-phosphorylation-and-extrinsic-apoptotic-pathway-in-non-small-cell
#3
Jaime Stella Moses Richardson, Norhaniza Aminudin, Sri Nurestri Abd Malek
Background: Plants have been a major source of inspiration in developing novel drug compounds in the treatment of various diseases that afflict human beings worldwide. Ruta angustifolia L. Pers known locally as Garuda has been conventionally used for various medicinal purposes such as in the treatment of cancer. Objective: A dihydrofuranocoumarin named chalepin, which was isolated from the chloroform extract of the plant, was tested on its ability to inhibit molecular pathways of human lung carcinoma (A549) cells...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141750/use-of-a-novel-portable-three-dimensional-scanner-to-measure-limb-volume-and-circumference-in-patients-with-filarial-lymphedema
#4
Channa Yahathugoda, Michael J Weiler, Ramakrishna Rao, Lalindi De Silva, J Brandon Dixon, Mirani V Weerasooriya, Gary J Weil, Philip J Budge
The World Health Organization's Global Program to Eliminate Lymphatic Filariasis (LF) has reduced LF transmission worldwide, but millions remain affected by filarial lymphedema. Tools for clinically monitoring lymphedema in developing nations are limited. We tested a novel, portable, infrared three-dimensional (3D) scanner against water displacement (WD) and tape measurement of limb circumference (TMLC) among patients with filarial leg lymphedema in Galle, Sri Lanka. Outcomes were accuracy and reproducibility of scanner measurements...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29139581/breast-radiology-malpractice-suits-characteristics-of-frequency-and-outcomes-national-and-statewide-distinctions
#5
Stephen R Baker, Sri Ram Pentakota, Basil Hubbi
The purpose of this study was to determine the frequency and outcomes of breast malpractice suits among all enrollees in One Call Medical Inc.'s panel of interpreting radiologists nationally and to evaluate state-by-state variations. The 8401 radiologists enrolled had 4764 suits, of which 826 were related to breast disease. In New York and New Jersey, the ratio of breast suits to One Call Radiologists was 0.28 and 0.27, twice as much as in any other state. Breast suits in radiology have a wide variation in frequency across the country with New York and New Jersey far exceeding all others in relative frequency and number of radiologists with multiple breast suits...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29138632/the-e-generation-the-technological-usage-and-experiences-of-medical-students-from-a-developing-country
#6
Priyasdarshani Galappatthy, Wasundara S Wathurapatha, Priyanga Ranasinghe, Maheshi D M S Wijayabandara, Dinuka S Warapitiya, Krishantha Weerasuriya
Background: The medical community is increasingly using Portable Electronic Devices (PEDs). We evaluated usage of PEDs and medical apps among medical students from Sri Lanka. Methods: This descriptive cross-sectional study was conducted at Faculty of Medicine, University of Colombo. Medical students from 2nd to 5th year were invited for the study. A self-administered questionnaire was used to collect details of PEDs availability, accessibility, and usage, perceived advantages/barriers of PEDs, and availability, accessibility, and usage of medical apps...
2017: International Journal of Telemedicine and Applications
https://www.readbyqxmd.com/read/29138302/disruption-of-the-opal-stop-codon-attenuates-chikungunya-virus-induced-arthritis-and-pathology
#7
Jennifer E Jones, Kristin M Long, Alan C Whitmore, Wes Sanders, Lance R Thurlow, Julia A Brown, Clayton R Morrison, Heather Vincent, Kayla M Peck, Christian Browning, Nathaniel Moorman, Jean K Lim, Mark T Heise
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean islands and the Americas that caused more than 1 million cases of viral arthralgia. Despite the major impact of CHIKV on global health, viral determinants that promote CHIKV-induced disease are incompletely understood. Most CHIKV strains contain a conserved opal stop codon at the end of the viral nsP3 gene...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29137662/peer-assisted-learning-among-sri-lankan-medical-undergraduates-a-cross-sectional-study
#8
Nipun Lakshitha de Silva, Balasundaram Parththipan, Chaturaka Rodrigo, Godwin Constantine, Sumadhya Deepika Fernando, Senaka Rajapakse
OBJECTIVE: The objectives of this study were to; (a) evaluate the current practices of peer assisted learning among second year and final year medical students of Faculty of Medicine, University of Colombo, Sri Lanka; (b) identify reasons for engaging in peer assisted learning; (c) identify perceived weaknesses in current learning activities; and (d) determine student characteristics associated with engaging in peer assisted learning. RESULTS: This cross sectional study interviewed two hundred and eighty-four eligible students...
November 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29135995/efficacy-of-a-new-rapid-diagnostic-test-kit-to-diagnose-sri-lankan-cutaneous-leishmaniasis-caused-by-leishmania-donovani
#9
Gayani De Silva, Vijani Somaratne, Sujai Senaratne, Manuja Vipuladasa, Rajitha Wickremasinghe, Renu Wickremasinghe, Shalindra Ranasinghe
BACKGROUND: Cutaneous leishmaniasis (CL) in Sri Lanka is caused by Leishmania donovani. This study assessed the diagnostic value of a new rapid diagnostic immunochromatographic strip (CL-Detect™ IC-RDT), that captures the peroxidoxin antigen of Leishmania amastigotes. METHODOLOGY/PRINCIPAL FINDINGS: We sampled 74 clinically suspected CL lesions, of which 59 (79.7%) were positive by PCR, 43 (58.1%) by Giemsa stained slit skin smear (SSS) and 21 (28.4%) by the new IC-RDT...
2017: PloS One
https://www.readbyqxmd.com/read/29134467/diterpenoid-natural-compound-c4-crassin-exerts-cytostatic-effects-on-triple-negative-breast-cancer-cells-via-a-pathway-involving-reactive-oxygen-species
#10
Cathy E Richards, Sri H Vellanki, Yvonne E Smith, Ann M Hopkins
PURPOSE: Triple-negative breast cancers (TNBC) lack expression of three common cell surface receptors, i.e., estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). Accordingly, TNBCs are associated with fewer treatment options and a relatively poor prognosis. Having screened a National Cancer Institute natural compound library, the purpose of this study was to investigate the bioactivity of compound C4 (Crassin) in TNBC cells. METHODS: Cell viability assays were performed in two TNBC cell lines, MDA-MB-231 and 4T1, following C4 treatment in the presence or absence of the antioxidant N-acetyl-L-cysteine (NAC)...
November 13, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29129451/cost-effectiveness-of-maternal-gbs-immunization-in-low-income-sub-saharan-africa
#11
Louise B Russell, Sun-Young Kim, Ben Cosgriff, Sri Ram Pentakota, Stephanie J Schrag, Ajoke Sobanjo-Ter Meulen, Jennifer R Verani, Anushua Sinha
BACKGROUND: A maternal group B streptococcal (GBS) vaccine could prevent neonatal sepsis and meningitis. Its cost-effectiveness in low-income sub-Saharan Africa, a high burden region, is unknown. METHODS: We used a decision tree model, with Markov nodes to project infants' lifetimes, to compare maternal immunization delivered through routine antenatal care with no immunization. 37 countries were clustered on the basis of economic and health resources and past public health performance...
November 9, 2017: Vaccine
https://www.readbyqxmd.com/read/29127001/long-term-intraocular-pressure-reduction-with-intracameral-polycaprolactone-glaucoma-devices-that-deliver-a-novel-anti-glaucoma-agent
#12
Jean Kim, Max Kudisch, Nina Rosa Konichi da Silva, Hiroyuki Asada, Eri Aya-Shibuya, Michele M Bloomer, Sri Mudumba, Robert B Bhisitkul, Tejal A Desai
Long-term treatment of glaucoma, a major leading cause of blindness, is challenging due to poor patient compliance. Therefore, a drug delivery device that can achieve drug release over several months can be highly beneficial for glaucoma management. Here, we evaluate the long-term pharmacokinetics and therapeutic efficacy of polycaprolactone intracameral drug delivery devices in rabbit eyes. Our study showed that a single drug delivery device loaded with a proprietary hypotensive agent, DE-117, reduced intraocular pressure in normotensive rabbits significantly for 23weeks...
November 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29124241/us-preventive-services-task-force-prostate-specific-antigen-screening-guidelines-result-in-higher-gleason-score-diagnoses
#13
Glen Gejerman, Patrick Ciccone, Martin Goldstein, Vincent Lanteri, Burton Schlecker, John Sanzone, Michael Esposito, Sergey Rome, Michael Ciccone, Eric Margolis, Robert Simon, Yijun Guo, Sri-Ram Pentakota, Hossein Sadhegi-Nejad
Purpose: To evaluate the impact that the 2012 US Preventive Services Task Force (USPSTF) prostate-specific antigen (PSA) screening guidelines have had on the diagnosis of prostate cancer, we compared the incidence and distribution of new cases diagnosed in 2011-before the USPSTF PSA screening recommendations versus 2014 at which time the guidelines were widely adopted. Materials and Methods: We identified all prostate biopsies performed by a large urology group practice utilizing a centralized pathology lab...
November 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29121980/a-complicated-prosthetic-valve-endocarditis-due-to-methicillin-resistant-staphylococci-treated-with-linezolid-and-ciprofloxacin-a-case-report
#14
C G K Amiyangoda, H Wimalaratna, S Bowatte
BACKGROUND: Prosthetic valve endocarditis (PVE) due to methicillin resistant Staphylococcus aureus (MRSA) is a rare disease with significant mortality and morbidity. With the emerging resistance and adverse effect profile of vancomycin which is the standard treatment, there is a compelling necessity of an effective alternative for vancomycin. Linezolid is proved as such an agent for infections caused by MRSA in other sites. However to-date the evidence for successful use of linezolid for MRSA prosthetic valve endocarditis is limited only for few case studies...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29116565/malaria-free-india-possibility-or-enigma
#15
REVIEW
B D Gupta, Rajkishore Maheshwari
Malaria, despite being treatable as well as preventable, is still quite prevalent in our country and is responsible for a large number of deaths. Though Govt. of India (GOI) has launched anti-malaria program since 1953 but is yet to achieve a zero malaria status. In SE Asia, two small countries, Maldives and Sri Lanka, have been declared Malaria free by WHO. Hence, we need to think why we cannot achieve this status? For this we need to study how these two countries were successful and what are our limitations/pitfalls...
November 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29115266/hiv-and-antenatal-care-in-sri-lanka-a-global-health-success
#16
Sophie Cousins
No abstract text is available yet for this article.
November 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29114735/residency-evaluations-where-is-the-patient-voice
#17
Sri Lekha Tummalapalli
No abstract text is available yet for this article.
November 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29113700/high-performance-dental-resin-composites-with-hydrolytically-stable-monomers
#18
Xiaohong Wang, George Huyang, Sri Vikram Palagummi, Xiaohui Liu, Drago Skrtic, Carlos Beauchamp, Rafael Bowen, Jirun Sun
OBJECTIVE: The objectives of this project were to: 1) develop strong and durable dental resin composites by employing new monomers that are hydrolytically stable, and 2) demonstrate that resin composites based on these monomers perform superiorly to the traditional bisphenol A glycidyl dimethacrylate/triethylene glycol dimethacrylate (Bis-GMA/TEGDMA) composites under testing conditions relevant to clinical applications. METHODS: New resins comprising hydrolytically stable, ether-based monomer, i...
November 4, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29113609/dermotropic-leishmania-donovani-in-sri-lanka-visceralizing-potential-in-clinical-and-preclinical-studies
#19
K K G D U L Kariyawasam, A Selvapandiyan, H V Y D Siriwardana, A Dube, P Karunanayake, S A S C Senanayake, R Dey, S Gannavaram, H L Nakhasi, N D Karunaweera
The visceralizing potential of apparently dermotropic Leishmania donovani in Sri Lanka (L. donovani-SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) patients and in vivo and in vitro experimental infection models. CL patients (n = 250) treated effectively with intra-lesional antimony therapy were followed-up six monthly for 4 years. There was no clinical evidence of visceralization of infection (VL) during this period. Infection of BALB/c mice with L. donovani-SL (test) through intra-dermal route led to the development of cutaneous lesions at the site of inoculation with no signs of systemic dissemination, in contrast to the observations made in animals similarly infected with a visceralizing strain of L...
November 8, 2017: Parasitology
https://www.readbyqxmd.com/read/29109892/topography-and-higher-order-corneal-aberrations-of-the-fellow-eye-in-unilateral-keratoconus
#20
Sibel Aksoy, Sezen Akkaya, Yelda Özkurt, Sevda Kurna, Banu Açıkalın, Tomris Şengör
Objectives: Comparison of topography and corneal higher order aberrations (HOA) data of fellow normal eyes of unilateral keratoconus patients with keratoconus eyes and control group. Materials and Methods: The records of 196 patients with keratoconus were reviewed. Twenty patients were identified as unilateral keratoconus. The best corrected visual acuity (BCVA), topography and aberration data of the unilateral keratoconus patients' normal eyes were compared with their contralateral keratoconus eyes and with control group eyes...
October 2017: Turkish Journal of Ophthalmology
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