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https://www.readbyqxmd.com/read/29352230/histology-immunohistochemistry-and-in-situ-hybridization-reveal-overlooked-ebola-virus-target-tissues-in-the-ebola-virus-disease-guinea-pig-model
#1
Timothy K Cooper, Louis Huzella, Joshua C Johnson, Oscar Rojas, Sri Yellayi, Mei G Sun, Sina Bavari, Amanda Bonilla, Randy Hart, Peter B Jahrling, Jens H Kuhn, Xiankun Zeng
Survivors of Ebola virus infection may become subclinically infected, but whether animal models recapitulate this complication is unclear. Using histology in combination with immunohistochemistry and in situ hybridization in a retrospective review of a guinea pig confirmation-of-virulence study, we demonstrate for the first time Ebola virus infection in hepatic oval cells, the endocardium and stroma of the atrioventricular valves and chordae tendinae, satellite cells of peripheral ganglia, neurofibroblasts and Schwann cells of peripheral nerves and ganglia, smooth muscle cells of the uterine myometrium and vaginal wall, acini of the parotid salivary glands, thyroid follicular cells, adrenal medullary cells, pancreatic islet cells, endometrial glandular and surface epithelium, and the epithelium of the vagina, penis and, prepuce...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351806/isolated-septic-arthritis-of-hip-joint-a-rare-presentation-of-melioidosis-a-case-report
#2
N P Weerasinghe, H M M Herath, T M U Liyanage
BACKGROUND: Despite, Sri Lanka lies in the melioidosis endemic belt between 5°N and 10°N surrounded by countries known to have endemic melioidosis for many years, comparatively fewer cases of melioidosis infection have been reported in Sri Lanka. Melioidosis has a wide spectrum of clinical presentation, ranging from severe pneumonia to abscess formation in various organs. Isolated septic arthritis, which is a rare but well-recognized manifestation of melioidosis, could be the sole presenting problem in some patients with melioidosis...
January 19, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29349928/problem-behaviours-and-psychotropic-medication-use-in-intellectual-disability-a-multinational-cross-sectional-survey
#3
B I Perry, H F Kwok, J Mendis, K Purandare, A Wijeratne, S Manjubhashini, M Dasari, F Esan, I Gunaratna, R A Naseem, S Hoare, V Chester, A Roy, J Devapriam, R Alexander, S E Cooray
BACKGROUND: Problem behaviours (PBs) are a common cause for clinician contact in people with disorders of intellectual development and may be a common cause for the prescription of psychotropic medication. We aimed to use a large, multinational sample to define the prevalence of PBs, the associations with psychotropic medication use, and to assess for any potential 'diagnostic overshadowing' by the label of PBs in a population of people with disorders of intellectual development. METHOD: A multinational, multi-setting, cross-sectional service evaluation and baseline audit was completed...
February 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29346115/mitochondrial-dysfunction-a-key-player-in-the-pathogenesis-of-cardiovascular-diseases-linked-to-air-pollution
#4
REVIEW
Sri Rahavi Boovarahan, Gino A Kurian
Air pollution has become an environmental burden with regard to non-communicable diseases, particularly heart disease. It has been reported that air pollution can accelerate the development of heart failure and atrial fibrillation. Air pollutants encompass various particulate matters (PMs), which change the blood composition and heart rate and eventually leads to cardiac failure by triggering atherosclerotic plaque ruptures or by developing irreversible ischemia. A series of major epidemiological and observational studies have established the noxious effect of air pollutants on cardiovascular diseases (CVD), but the underlying molecular mechanisms of its susceptibility and the pathological disease events remain largely elusive and are predicted to be initiated in the cell organelle...
January 18, 2018: Reviews on Environmental Health
https://www.readbyqxmd.com/read/29345220/tissue-impression-smears-as-a-supplementary-diagnostic-method-for-histopathology-in-cutaneous-leishmaniasis-in-sri-lanka
#5
Nuwani H Manamperi, M Vipula C de Silva, Nishantha Pathirana, Wimal Abeyewickreme, Nadira D Karunaweera
Cutaneous leishmaniasis (CL) is diagnosed mainly by light microscopy of smears made using lesion material. Histopathology is usually done in atypical presentations or when lesion smears are negative. Tissue impression smears (TIS) made from skin biopsy specimens were compared with histopathology for the diagnosis of CL. Out of the 111 patients included, 83 (74.8%) were positive by either methods. The TIS was positive in 70.3% whereas histopathology was positive in 56.8% of patients. Tissue impression smears can be used as a supplementary diagnostic test that gives sensitive and rapid results when tissue biopsies are used as the source of lesion material for diagnosis of CL...
January 15, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29343229/the-colombo-twin-and-singleton-follow-up-study-a-population-based-twin-study-of-psychiatric-disorders-and-metabolic-syndrome-in-sri-lanka
#6
Kaushalya Jayaweera, Lisa Aschan, Gayani Pannala, Anushka Adikari, Nicholas Glozier, Khalida Ismail, Carmine M Pariante, Fruhling Rijsdijk, Sisira Siribaddana, Helena M S Zavos, Patricia A Zunszain, Athula Sumathipala, Matthew Hotopf
BACKGROUND: The disease burden related to mental disorders and metabolic syndrome is growing in low-and middle-income countries (LMIC). The Colombo Twin and Singleton Study (COTASS) is a population-based sample of twins and singletons in Colombo, Sri Lanka. Here we present prevalence estimates for metabolic syndrome (metS) and mental disorders from a follow-up (COTASS-2) of the original study (COTASS-1), which was a mental health survey. METHODS: In COTASS-2, participants completed structured interviews, anthropometric measures and provided fasting blood and urine samples...
January 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29342263/sri-lanka-s-post-tsunami-health-system-recovery-a-qualitative-analysis-of-physician-perspectives
#7
William Collin Schenk, Thuy Bui
Background: The 2004 Indian Ocean tsunami caused significant damage to the health system in Sri Lanka. Rebuilding infrastructure and improving the mental health system were targets of recovery policies. Retrospective analyses of the post-tsunami health system recovery in Sri Lanka lack the perspectives of local stakeholders, including health care providers. Methods: In 2014 we interviewed 23 Sri Lankan physicians from the Eastern and Southern regions. Participants were recruited with snowball sampling...
January 12, 2018: International Health
https://www.readbyqxmd.com/read/29338492/genetic-variation-of-gria3-gene-is-associated-with-vulnerability-to-methamphetamine-dependence-and-its-associated-psychosis
#8
Sri-Arun Iamjan, Samur Thanoi, Paritat Watiktinkorn, Gavin P Reynolds, Sutisa Nudmamud-Thanoi
Methamphetamine (METH) is an addictive psychostimulant drug commonly leading to schizophrenia-like psychotic symptoms. Disturbances in glutamatergic neurotransmission have been proposed as neurobiological mechanisms and the α-amino-3 hydroxy-5 methyl-4 isoxazole propionic acid (AMPA) glutamate receptor has been implicated in these processes. Moreover, genetic variants in GRIAs, genes encoding AMPA receptor subunits, have been observed in association with both drug dependence and psychosis. We hypothesized that variation of GRIA genes may be associated with METH dependence and METH-induced psychosis...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29336953/effective-use-of-iron-aluminum-rich-laterite-based-soil-mixture-for-treatment-of-landfill-leachate
#9
I V K Nayanthika, D T Jayawardana, N J G J Bandara, P M Manage, R M T D Madushanka
Landfill leachate poses environmental threats worldwide and causes severe issues on adjacent water bodies and soil by direct discharge. The primary objective of this study is to analyze the efficient use of compost and laterite mixtures (0, 10, 20, 30 and 40 wt% compost/laterite) on leachate treatment and to investigate the associated removal efficiencies under different sorption processes. Therefore, in the experimental design, laterite is used for providing adsorption characteristics, and compost for activating biological properties of the filter...
January 11, 2018: Waste Management
https://www.readbyqxmd.com/read/29334827/left-ventricular-pseudoaneurysms-in-children-a-case-series
#10
Prasad Sreevathsa, Duvuru Ram, Hemachandren Munuswamy, Davulury Sri Satyavathi, Bathal Vedagiri Sai Chandran
Left ventricular pseudoaneurysms are very rare in children. In children, left ventricular pseudoaneurysms can occur following infection, trauma, ischemia, or cardiac surgery. The authors report a series of three cases treated at our hospital with two of the cases having a history of extrapulmonary tuberculosis and one patient with a history of varicella zoster infection.
January 1, 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29333051/therapeutic-significance-of-loligo-vulgaris-lamarck-1798-ink-extract-a-biomedical-approach
#11
Sri Kumaran Nadarajah, Radha Vijayaraj, Jayaprakashvel Mani
Background: The squid ink extract is well known for its biomedical properties. Objective: In this study, squid Loligo vulgaris was collected from Tuticorin costal water, Bay of Bengal, India. Materials and Methods: Proximate composition of the crude squid ink was studied and found to have protein as the major component over lipid and carbohydrates. Further, bioactive fractions of squid ink were extracted with ethanol, and therapeutic applications such as hemolytic, antioxidant, antimicrobial, and in vitro anti-inflammatory properties were analyzed using standard methods...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29333035/the-activity-of-immunoglobulin-y-anti-mycobacterium-tuberculosis-on-proliferation-and-cytokine-expression-of-rat-peripheral-blood-mononuclear-cells
#12
Sri Agus Sudjarwo, Koerniasari Eraiko, Giftania Wardani Sudjarwo, Koerniasari
Objective: It has long been known that chickens, like mammals, are capable of producing antigen-specific immunoglobulin Y (IgY), which functions similar to IgG. The present study was performed to investigate the activity of IgY anti-Mycobacterium tuberculosis on proliferation, interleukin (IL)-2, and interferon (IFN)-γ expression of rat peripheral blood mononuclear cells (PBMCs). Materials and Methods: The activity of IgY anti-M. tuberculosis in different doses (25, 50, and 100 μg/ml) on rat PBMCs proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332508/battered-wives-or-dependent-mothers-negotiating-familial-ideology-in-law
#13
Chulani Kodikara
More than a decade after its passing, Sri Lanka's Prevention of Domestic Violence Act (PDVA) remains a remedy of last resort for female survivors of intimate partner violence, as there is little support to take on a rights-defined identity as a battered woman both inside and outside the courtroom. However, large numbers of women are accessing the Maintenance Act of 1999 to exit violent relationships without the censure and stigma that attaches to the PDVA. The key to understanding this phenomenon is to consider how familial ideology works in unpredictable ways within the Sri Lankan judicial system...
September 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29329051/non-genetic-engineering-of-cytotoxic-t-cells-to-target-il-4-receptor-enhances-tumor-homing-and-therapeutic-efficacy-against-melanoma
#14
Gowri Rangaswamy Gunassekaran, Chae-Moon Hong, Sri Murugan Poongkavithai Vadevoo, Lianhua Chi, Padmanaban Guruprasath, Byung-Cheol Ahn, Ha-Jeong Kim, Tae Heung Kang, Byungheon Lee
Adoptive transfer of cytotoxic T lymphocytes (CTLs) has been used as an immunotherapy in melanoma. However, the tumor homing and therapeutic efficacy of transferred CTLs against melanoma remain unsatisfactory. Interleukin-4 receptor (IL-4R) is commonly up-regulated in tumors including melanoma. Here, we studied whether IL-4R-targeted CTLs exhibit enhanced tumor homing and therapeutic efficacy against melanoma. CTLs isolated from mice bearing melanomas were non-genetically engineered with IL4RPep-1, an IL-4R-binding peptide, using a membrane anchor composed of dioleylphosphatidylethanolamine...
January 8, 2018: Biomaterials
https://www.readbyqxmd.com/read/29326973/a-rare-case-of-endometrial-cancer-metastatic-to-the-uveal-choroid
#15
Stephanie H Smith, Sri Krishna C Arudra, Mary M Mullen, Marguerite Palisoul, Sonika Dahiya, P Kumar Rao, Premal H Thaker
•Choroid metastases are extremely rare in endometrial cancer.•Choroid metastases can present as many different eye complaints.•Comprehensive eye exams are important in patients with visual complaints.
February 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29326088/age-effects-of-distinct-immune-checkpoint-blockade-treatments-in-a-mouse-melanoma-model
#16
Álvaro Padrón, Vincent Hurez, Harshita B Gupta, Curtis A Clark, Sri Lakshmi Pandeswara, Bin Yuan, Robert S Svatek, Mary Jo Turk, Justin M Drerup, Rong Li, Tyler J Curiel
Cancer immunotherapy has shown remarkable recent progress. Immune checkpoint blocking antibodies have become the most successful anti-cancer agent class ever developed, with six distinct agents approved since 2011 for a wide variety of cancers. Although age is the biggest risk factor for cancer (aside from selected early-onset pediatric cancers), these agents were tested pre-clinically in young hosts, and there is remarkably little published on the effects of host age on treatment outcomes in pre-clinical studies or human clinical trials...
January 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29325544/prevalence-and-associated-factors-of-wheezing-illnesses-of-children-aged-three-to-five-years-living-in-under-served-settlements-of-the-colombo-municipal-council-in-sri-lanka-a-cross-sectional-study
#17
Ruwanika Seneviratne, Nalika S Gunawardena
BACKGROUND: A rising trend in Sri Lanka for asthma and wheezing illness is observed with higher morbidity in younger children and a paucity of related research. 'Under-served settlements' (USS) of Colombo Municipal Council (CMC) have poor living environments conducive to childhood wheezing. The objective was to describe the prevalence and associated factors of wheezing illnesses of three to five year old children living in low-income settlements in CMC. METHODS: A cross-sectional study was conducted on 460 three to five year old children and their caregivers using cluster sampling among residents of two randomly selected USSs of CMC...
January 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29322863/transcultural-factors-related-to-depressive-psychopathology-in-sri-lankan-migrants-living-in-australia
#18
Miyuru Chandradasa, Layani Champika
No abstract text is available yet for this article.
January 1, 2018: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29322622/ten-years-of-clinical-trial-registration-in-a-resource-limited-setting-experience-of-the-sri-lanka-clinical-trials-registry
#19
Udaya K Ranawaka, Ashwini de Abrew, Manu Wimalachandra, Nithushi Samaranayake, Colvin Goonaratna
AIM: We describe our experience of the first 10 years at the Sri Lanka Clinical Trials Registry (SLCTR). METHODS: We analyzed all trial records of the SLCTR over the study period. We collected information regarding trial characteristics and completeness of data entry in the SLCTR data set. RESULTS: During the study period, 210 trials (63% of all applications) were registered with the SLCTR. The number of registered trials showed an increasing trend over the years...
January 11, 2018: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/29322315/effects-of-a-casein-hydrolysate-versus-intact-casein-on-gastric-emptying-and-amino-acid-responses
#20
Katy Horner, Elaine Drummond, Victoria O'Sullivan, Pedapati S C Sri Harsha, Lorraine Brennan
PURPOSE: Milk proteins and/or their hydrolysates have been reported to have beneficial effects for improving postprandial glycaemia. Gastric emptying is a major determinant of postprandial glycaemia, yet limited studies have examined the effects of intact milk proteins compared to hydrolysates on gastric emptying. We investigated gastric emptying of a casein hydrolysate compared to intact casein. METHODS: Nine overweight and obese adults (mean ± SD age: 59...
January 10, 2018: European Journal of Nutrition
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