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leukoaraiosis

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https://www.readbyqxmd.com/read/29329733/association-between-leukoaraiosis-and-cerebral-blood-flow-territory-alteration-in-asymptomatic-internal-carotid-artery-stenosis
#1
Y-F Chen, Y-S Kuo, W-C Wu, S-C Tang, S-F Jiang
AIM: To test the hypothesis that leukoaraiosis (also known as white matter lesion) is associated with cerebral blood flow territory change as revealed by territorial arterial spin-labeling (TASL) magnetic resonance imaging (MRI) in patients with asymptomatic internal carotid artery stenosis (aICAS). MATERIALS AND METHODS: The institutional review board approved this study. Thirty-three patients with aICAS were included prospectively and divided into high-grade (ultrasonographic stenosis ≥70%, n=17) and low-grade (n=16) groups; 16 healthy subjects were also included...
January 9, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29288062/the-degree-of-leukoaraiosis-predicts-clinical-outcomes-and-prognosis-in-patients-with-middle-cerebral-artery-occlusion-after-intravenous-thrombolysis
#2
Yanyan Liu, Min Zhang, Yuan Chen, Ping Gao, Wenwei Yun, Xianju Zhou
Leukoaraiosis (LA) is common in elderly patients with ischemic stroke on magnetic resonance imaging. In this study, we investigate whether the degree of LA is associated with clinical outcomes and prognosis of patients with middle cerebral artery occlusion following intravenous thrombolytic. Ninety-seven patients were recruited and divided into three groups based on the degree of LA (no, mild and moderate to severe LA) by the Fazekas scale. Clinical outcomes, recurrent stroke, Fugl-Meyer rating scale (FMS) and complications of intravenous thrombolysis were assessed...
December 26, 2017: Brain Research
https://www.readbyqxmd.com/read/29275589/-characteristics-of-cognitive-impairment-and-the-resting-state-functional-mri-in-patients-with-leukoaraiosis
#3
Q Li, L Q Zhao, F Y Hu
Objective: To investigate the features of cognitive impairment and potential physiopathologic mechanism using neuropsychological assessment and resting state functional magnetic resonance imaging (rs-fMRI) in patients with leukoaraiosis (LA). Methods: A total of 13 patients with LA (LA group) and 13 healthy controls (NC group) from Shanxi Provincial People's Hospital between January and June 2016 were recruited. The two groups were matched for age, sex, education, and vascular risk factors. All the subjects underwent neuropsychological assessment and the scan of rs-fMRI...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29210074/white-matter-degeneration-in-vascular-and-other-ageing-related-dementias
#4
REVIEW
Yoshika Hase, Karen Horsburgh, Masafumi Ihara, Raj N Kalaria
Advances in neuroimaging have enabled greater understanding of the progression of cerebral degenerative processes associated with ageing-related dementias. Leukoaraiosis or rarefied white matter (WM) originally described on computed tomography is one of the most prominent changes which occurs in older age. White matter hyperintensities (WMH) evident on magnetic resonance imaging have become commonplace to describe WM changes in relation to cognitive dysfunction, types of stroke injury, cerebral small vessel disease and neurodegenerative disorders including Alzheimer's disease...
December 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29207392/distinct-roles-of-endothelial-dysfunction-and-inflammation-in-intracranial-atherosclerotic-stroke
#5
Jong-Won Chung, Mi Jeong Oh, Yeon Hee Cho, Gyeong Joon Moon, Gyeong-Moon Kim, Chin-Sang Chung, Kwang Ho Lee, Oh Young Bang
BACKGROUND/AIMS: The aim of the study was to evaluate the differential roles of endothelial dysfunction and inflammation in intracranial atherosclerotic stroke (ICAS). METHODS: We prospectively recruited 262 patients with acute cerebral infarcts caused by ICAS and 75 individuals with no history of stroke as controls. Markers of endothelial dysfunction (asymmetric dimethylarginine, ADMA) and inflammation (lipoprotein-associated phospholipase A2, Lp-PLA2) were measured...
2017: European Neurology
https://www.readbyqxmd.com/read/29170268/leukoaraiosis-attenuates-diagnostic-accuracy-of-large-vessel-occlusion-scales
#6
Y Mayasi, R P Goddeau, M Moonis, B Silver, A H Jun-O'Connell, A S Puri, N Henninger
BACKGROUND AND PURPOSE: Prehospital stroke scales may help identify patients likely to have large-vessel occlusion to facilitate rapid triage to thrombectomy-capable stroke centers. Scale misclassification may result in inaccurate decisions and possible harm. Pre-existing leukoaraiosis has been shown to attenuate the association between deficit type and stroke severity. We sought to determine whether leukoaraiosis affects the predictive ability of 5 commonly used large-vessel occlusion scales...
November 23, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29099708/neuroimaging-characteristics-and-post-stroke-fatigue-within-the-first-6-months-after-ischemic-strokes
#7
M Delva, I Delva
Aim - identify neuroimaging characteristics associated with different post-stroke fatigue (PSF) domains within first 6 months after ischemic strokes. There were enrolled in the study 107 patients with acute ischemic strokes. General PSF and certain PSF domains (global, physical, mental, motivational, activity-related) were measured by multidimensional fatigue inventory-20 (MFI-20) scale at hospital stay, in 1, 3 and 6 months after stroke occurrence. Brain MRI studies included cerebral infarct localization, planimetric measurements of infarct volumes, measurement of brain atrophy indexes (bifrontal, bicaudate, cortical atrophy indexes, width of third ventricle) and evaluation of leukoaraiosis severity, according to Fazekas scale...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29058014/quantitative-rapid-assessment-of-leukoaraiosis-in-ct-comparison-to-gold-standard-mri
#8
Uta Hanning, Peter Bernhard Sporns, Rene Schmidt, Thomas Niederstadt, Jens Minnerup, Georg Bier, Stefan Knecht, André Kemmling
PURPOSE: The severity of white matter lesions (WML) is a risk factor of hemorrhage and predictor of clinical outcome after ischemic stroke; however, in contrast to magnetic resonance imaging (MRI) reliable quantification for this surrogate marker is limited for computed tomography (CT), the leading stroke imaging technique. We aimed to present and evaluate a CT-based automated rater-independent method for quantification of microangiopathic white matter changes. METHODS: Patients with suspected minor stroke (National Institutes of Health Stroke scale, NIHSS < 4) were screened for the analysis of non-contrast computerized tomography (NCCT) at admission and compared to follow-up MRI...
October 20, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28980613/-cognitive-impairment-and-compliance-in-chronic-heart-failure
#9
M V Shestakova, A F Vasilenko, M I Karpova, E A Grigoricheva, N V Epaneshnikova, I V Kochetkov
AIM: To determine the factors of cognitive impairment and non-compliance in patients with chronic heart failure (CHF). MATERIAL AND METHODS: One hundred and fifty-seven patients with CHF and 32 patients without chronic heart failure (controls) were examined. Neuropsychological assessment using a 30-minutes protocol recommended by NINDS-Canadian Stroke Standards (NINDS CSS), magnetic resonance imaging, cognitive ERP and a test of compliance were used. RESULTS AND CONCLUSION: Approximately 62% of patients did not perform medical prescriptions...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28980608/-neuroimaging-and-molecular-biomarkers-of-dementia
#10
T A Polyakova, A V Arablinsky
Development of laboratory diagnosis and neuroimaging revealed a number of biomarkers for in vivo diagnosis of the most common forms of dementia (Alzheimer's disease, Lewy body dementia and vascular dementia). Currently, the highest diagnostic sensitivity and specificity of molecular biomarkers in the cerebrospinal fluid are detected for Alzheimer's disease. At the same time, the changes according to the magnetic resonance imaging are more prognostically significant for future cognitive decline than cerebrospinal fluid biomarkers...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28953609/incidence-and-risk-factors-of-leukoaraiosis-from-4683-hospitalized-patients-a-cross-sectional-study
#11
Qing Lin, Wen-Qing Huang, Qi-Lin Ma, Cong-Xia Lu, Sui-Jun Tong, Jin-Hu Ye, Hui-Nuan Lin, Long Gu, Ke-Hui Yi, Liang-Liang Cai, Chi-Meng Tzeng
Leukoaraiosis (LA) refers to white matter hyperintensities or white matter lesions (WMLs) on magnetic resonance imaging (MRI) scans of the brain; this disease is associated with an increased risk of stroke, dementia, and cognitive decline. The aims of the study are to assess the incidence of LA and its associated risk factors in a Chinese population.A hospital-based cross-sectional study was conducted that included 4683 patients who were 40 years or older. Data collected included age, sex, hypertension, diabetes, smoking, drinking, homocysteine (HCY), and low-density lipoprotein cholesterol (LDL-C) levels in the blood in addition to brain MRI information...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28872448/blood-pressure-variability-and-leukoaraiosis-in-acute-ischemic-stroke
#12
David A Dickie, Benjamin Aribisala, Grant Mair, Eivind Berge, Richard I Lindley, Peter Sandercock, Rudiger von Kummer, Anders von Heijne, Andre Peeters, Lesley Cala, Andrew Farrall, Zoe Morris, Nick Bradey, Gillian Potter, Alessandro Adami, Joanna M Wardlaw
Higher blood pressure, blood pressure variability, and leukoaraiosis are risk factors for early adverse events and poor functional outcome after ischemic stroke, but prior studies differed on whether leukoaraiosis was associated with blood pressure variability, including in ischemic stroke. In the Third International Stroke Trial, blood pressure was measured in the acute phase of ischemic stroke immediately prior to randomization, and at 0.5, 1, and 24 h after randomization. Masked neuroradiologists rated index infarct, leukoaraiosis, and atrophy on CT using validated methods...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28829216/leukoaraiosis-as-an-outcome-predictor-in-the-acute-and-subacute-phases-of-stroke
#13
Fabio Fierini, Anna Poggesi, Leonardo Pantoni
Leukoaraiosis (LA) is one of the neuroimaging features of cerebral small vessel disease and is associated with poor long-term prognosis. Areas covered: This narrative review focuses on the predictive role of LA on the evolution of the ischemic brain damage and on the clinical outcome in the subacute phase of stroke and in the short-term period afterwards. Expert commentary: LA predicts poorer tissue outcome and clinical prognosis also in acute and subacute stroke. In acute stroke, LA is associated with a less favorable fate of brain infarct and is a marker of increased risk of thrombolysis-related hemorrhagic transformation...
September 4, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28790269/-brain-protection-for-shaggy-aorta-during-aortic-arch-surgery
#14
Kenji Okada
Although short and long-term outcomes of aortic surgeries have been improving over the past decade, the procedure is likely to be asscociated with life-threatening complications such as neurological deficits caused by suboptimal brain protection or heavily diseased aorta. Contemporary strategies for brain protection are deep hypothermic arrest with or without retrograde cerebral perfusion retrograde cerebral perfusion or selective antegrade cerebral perfusion. At the moment, majority of evidences failed to show the superiority of selective antegrade cerebral perfusion to retrograde one...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28752500/negative-impact-of-leukoaraiosis-on-the-incidence-of-brain-metastases-in-patients-with-lung-cancer
#15
Nakamasa Hayashi, Koichi Mitsuya, Yoko Nakasu, Tateaki Naito, Fumiharu Ohka, Toshiaki Takahashi
The embolization of cancer cells to cerebral vessels occurs early in the multi-step metastatic process. We aimed to determine whether the presence of leukoaraiosis (LA) before treatment would predict the development of brain metastases (BM) in patients with lung cancer. Between January 2014 and June 2015, 1007 patients underwent initial (i.e., prior to any chemotherapy) or routine magnetic resonance (MR) imaging of the brain and exhibited no evidence of BM. Of these, 189 underwent repeat MR imaging; 34 of 189 patients (18%) developed new BM, whereas 155 patients did not...
November 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28688715/multiple-silent-brain-infarcts-are-associated-with-severer-stroke-in-patients-with-first-ever-ischemic-stroke-without-advanced-leukoaraiosis
#16
Da-Wei Chen, Yu-Xi Wang, Jin Shi, Wei-Qing Zhang, Fen Yang, Yan-Wei Yin, Lu-Na Ma
BACKGROUND: Silent brain infarct (SBI) is associated with symptomatic stroke, but the association between SBI and acute ischemic stroke severity is uncertain. We aimed at investigating the association between SBI number and stroke severity in patients with first-ever ischemic stroke without advanced leukoaraiosis. METHODS: This study included 115 patients with first-ever ischemic stroke without advanced leukoaraiosis. National Institutes of Health Stroke Scale (NIHSS) scores were measured...
September 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28678575/ischemic-white-matter-lesions-associated-with-medullary-arteries-classification-of-mri-findings-based-on-the-anatomic-arterial-distributions
#17
REVIEW
Toshiaki Akashi, Shoki Takahashi, Shunji Mugikura, Shiho Sato, Takaki Murata, Atsushi Umetsu, Kei Takase
OBJECTIVE: The purposes of this article are to describe the important role of the medullary arteries in the pathogenesis of cerebral vascular disease and to present a classification of MRI findings of ischemic white matter lesions for use in elucidating pathogenesis. CONCLUSION: From the viewpoint of the anatomy of the medullary arteries, the pattern of medullary artery-related ischemic changes and infarcts can be classified into four types: 1, ischemic leukoaraiosis; 2, infarcts involving individual medullary arteries; 3, watershed infarcts; and 4, territorial infarcts...
September 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28677780/spectrum-construction-of-differentially-expressed-circular-rnas-in-patients-with-leukoaraiosis-and-function-analysis-of-differentially-expressed-genes
#18
Te Mi, Changjiang Luo, Yawei Hu, Chuanqiang Qu, Xiang Wang, Shougang Guo, Yifeng Du
Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA cases and 6 samples from control cases. Differentially expressed (DE) circRNAs between two samples were identified through fold‑change (>1.5‑fold) screening. Afterwards, based on DE circRNAs, the gene ontology (GO) analysis of upregulated DE genes identified from DE circRNAs demonstrated that DE genes were primarily associated with cellular metabolic processes, membrane‑bound organelles and binding...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28663254/blood-pressure-and-heart-rate-measures-associated-with-increased-risk-of-covert-brain-infarction-and-worsening-leukoaraiosis-in-older-adults
#19
Lester Y Leung, Traci M Bartz, Kenneth Rice, James Floyd, Bruce Psaty, Jose Gutierrez, W T Longstreth, Kenneth J Mukamal
OBJECTIVE: In people without previous stroke, covert findings on serial magnetic resonance imaging (MRI) of incident brain infarcts and worsening leukoaraiosis are associated with increased risk for ischemic stroke and dementia. We evaluated whether various measures of blood pressure (BP) and heart rate are associated with these MRI findings. APPROACH AND RESULTS: In the CHS (Cardiovascular Health Study), a longitudinal cohort study of older adults, we used relative risk regression to assess the associations of mean, variability, and trend in systolic BP, diastolic BP, and heart rate measured at 4 annual clinic visits between 2 brain MRIs with incident covert brain infarction and worsening white matter grade (using a 10-point scale to characterize leukoaraiosis)...
August 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28659787/better-correlation-of-cognitive-function-to-white-matter-integrity-than-to-blood-supply-in-subjects-with-leukoaraiosis
#20
Genlong Zhong, Ruiting Zhang, Yerfan Jiaerken, Xinfeng Yu, Ying Zhou, Chang Liu, Longting Lin, Lusha Tong, Min Lou
Leukoaraiosis is associated with increased risk of cognitive impairment, but its pathophysiological pathway is unclear. The aim of the present study was to determine whether brain structural damage or cerebral blood supply better correlated with the global cognitive outcome in subjects with leukoaraiosis. Seventy-five subjects with leukoaraiosis were included in present study, with age ranged from 43 to 85 years, with mean white matter hyperintensities (WMH) volume 30.69 ± 24.35 mL. Among them, 19(25.33%) subjects presented with cerebral microbleeds (CMB) and 40 (53...
2017: Frontiers in Aging Neuroscience
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