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https://www.readbyqxmd.com/read/29045670/impact-of-age-related-mitochondrial-dysfunction-and-exercise-on-intestinal-microbiota-composition
#1
David Houghton, Christopher J Stewart, Craig Stamp, Andrew Nelson, Nadim J Ajami, Joseph F Petrosino, Anil Wipat, Michael I Trenell, Douglass M Turnbull, Laura C Greaves
Mitochondrial dysfunction is prevalent in the ageing gastrointestinal tract. We investigated whether mitochondrial function in ageing colonic crypts and exercise influence microbial gut communities in mice. Twelve PolgAmut/mut mice were randomly divided into a sedentary and exercise group at 4 months. Seven aged matched PolgA+/+ mice remained sedentary throughout. Stool samples were collected at 4, 7 and 11 months, and bacterial profiling was achieved through 16S rDNA sequencing profiling. Mitochondrial enzyme activity was assessed in colonic epithelial crypts at 11 months for PolgAmut/mut and PolgA+/+ mice...
October 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29045388/inflammatory-memory-sensitizes-skin-epithelial-stem-cells-to-tissue-damage
#2
Shruti Naik, Samantha B Larsen, Nicholas C Gomez, Kirill Alaverdyan, Ataman Sendoel, Shaopeng Yuan, Lisa Polak, Anita Kulukian, Sophia Chai, Elaine Fuchs
The skin barrier is the body's first line of defence against environmental assaults, and is maintained by epithelial stem cells (EpSCs). Despite the vulnerability of EpSCs to inflammatory pressures, neither the primary response to inflammation nor its enduring consequences are well understood. Here we report a prolonged memory to acute inflammation that enables mouse EpSCs to hasten barrier restoration after subsequent tissue damage. This functional adaptation does not require skin-resident macrophages or T cells...
October 18, 2017: Nature
https://www.readbyqxmd.com/read/29045314/repeated-sprint-ability-in-division-i-collegiate-male-soccer-players-positional-differences-and-relationships-with-performance-tests
#3
Robert G Lockie, Matthew R Moreno, Ashley J Orjalo, Alyssa A Stage, Tricia M Liu, Samantha A Birmingham-Babauta, Jillian M Hurley, Ibett A Torne, Megan D Beiley, Fabrice G Risso, DeShaun L Davis, Adrina Lazar, John J Stokes, Dominic V Giuliano
Repeated-sprint ability (RSA) in essential for soccer. Important considerations when assessing RSA is whether there are differences between positions (defenders, midfielders, forwards), and what physiological characteristics may contribute to RSA. This has not been assessed in collegiate male players. Eighteen Division I male field players from one school performed several performance tests. The RSA test involved 7 x 30-m sprints completed on 20-s cycles. Measurements included total time (TT), and performance decrement (percent change in time from the first to last sprint; PD)...
October 16, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29045302/neurosteroid-levels-in-patients-with-bipolar-disorder-and-a-history-of-cannabis-use-disorders
#4
Brittany L Mason, Erin Van Enkevort, Francesca Filbey, Christine E Marx, John Park, Alyson Nakamura, Prabha Sunderajan, E Sherwood Brown
PURPOSE/BACKGROUND: In animal models, levels of the neurosteroid pregnenolone increase after tetrahydrocannabinol (THC) administration and pregnenolone appears to attenuate the brain effects of THC. Given these interactions between pregnenolone and THC, we evaluated baseline neurosteroid levels in participants with a history of a cannabis use disorders (CUDs). METHODS/PROCEDURES: Bipolar depressed participants were enrolled in a randomized placebo-controlled clinical trial to evaluate the efficacy of add-on pregnenolone for depression and before receiving pregnenolone or placebo...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29043249/interactions-between-bacteria-and-bile-salts-in-the-gastrointestinal-and-hepatobiliary-tracts
#5
REVIEW
Verónica Urdaneta, Josep Casadesús
Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal homeostasis by controlling the size and the composition of the intestinal microbiota. As a consequence, alteration of the microbiome-bile salt homeostasis can play a role in hepatic and gastrointestinal pathological conditions. Intestinal bacteria use bile salts as environmental signals and in certain cases as nutrients and electron acceptors...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29043082/effect-of-sex-and-age-on-traumatic-brain-injury-a-geographical-comparative-study
#6
Raaj Kishore Biswas, Enamul Kabir, Rachel King
BACKGROUND: Traumatic brain injury (TBI) is a much researched topic in medical health, which requires additional studies to understand various effects of demographic and geographic factors that can assist in developing the most effective treatments. Thousands of people of different ages are suffering from lifelong disabilities, either mild or severe, from TBI and the number is increasing. This study aims to increase our understanding of the effect of sex and age by applying five different statistical methods to evaluate the effect of these covariates on two independent TBI data sets representing patients from different geographical cohorts...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29042172/effect-of-upper-limb-rehabilitation-compared-to-no-upper-limb-rehabilitation-in-lung-transplant-recipients-a-randomized-controlled-trial
#7
L M Fuller, D El-Ansary, B M Button, M Corbett, G Snell, S Marasco, A E Holland
OBJECTIVE: to investigate effects of a supervised UL exercise program (SULP) versus no supervised UL exercise program (NULP) after lung transplantation (LTX). DESIGN: Randomized controlled trial SETTING: Physiotherapy gym PARTICIPANTS: Post LTX>18years, N=80 INTERVENTION: All participants underwent lower limb strength thrice weekly and endurance training. Participants randomised to supervised upper limb program (SULP) completed progressive UL strength training program using hand weights & adjustable pulley equipment...
October 14, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29041955/pluripotent-nontumorigenic-multilineage-differentiating-stress-enduring-cells-muse-cells-a-seven-year-retrospective
#8
REVIEW
Samantha C Fisch, María L Gimeno, Julia D Phan, Ariel A Simerman, Daniel A Dumesic, Marcelo J Perone, Gregorio D Chazenbalk
Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers...
October 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29041800/an-exploration-of-the-knowledge-attitudes-and-beliefs-of-xhosa-men-concerning-traditional-circumcision
#9
Salome Froneman, Paul A Kapp
BACKGROUND: The practice of traditional circumcision is associated with considerable morbidity and mortality, yet there is a paucity of literature that provides an understanding of the cultural values that influence men to choose traditional rather than medical circumcision.The aim of this study was to better understand the culture surrounding traditional circumcision, with a view to addressing morbidity and mortality rates associated with the Xhosa male initiation rituals.We explored Xhosa men's perceptions regarding the need for the risks and the social pressure to undergo traditional circumcision, the impact of non-initiation or failed initiation and the perceived barriers to obtaining medical help for the complications of traditional circumcisions...
October 13, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29041799/the-value-of-the-wirhe-scholarship-programme-in-training-health-professionals-for-rural-areas-views-of-participants
#10
Nontsikelelo O Mapukata, Ian Couper, Jocelyn Smith
INTRODUCTION: Rural hospitals in South Africa, as elsewhere, face enduring shortages of, and challenges in attracting and retaining, suitably qualified staff. The Wits Initiative for Rural Health Education (WIRHE), based at the University of the Witwatersrand but covering three universities, is a rural scholarship programme established to find local solutions to these challenges in the North West and Mpumalanga provinces. The purpose of this evaluation was to ascertain whether the WIRHE project was achieving its objectives...
October 13, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29040405/the-balcony-technique-of-breast-augmentation-and-inverted-t-mastopexy-with-an-inferior-dermoglandular-flap
#11
Roy de Vita, Giovanni Zoccali, Ernesto Maria Buccheri
Background: Optimal breast augmentation-mastopexy involves a reliable technique, fast recovery, minimal complications, and aesthetic results that are excellent and enduring. Objectives: The authors sought to determine whether the balcony technique of augmentation-mastopexy was safe and yielded satisfactory long-term outcomes in patients with breast ptosis and hypoplasia. Methods: The authors conducted a retrospective review of 207 patients who underwent subglandular augmentation and inverted-T mastopexy with a customized Wise keyhole resection pattern and an inferior flap...
October 4, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040219/effect-of-2-years-of-endurance-and-high-impact-training-on-preventing-osteoporosis-in-postmenopausal-women-randomized-clinical-trial
#12
Carmen García-Gomáriz, José M Blasco, Cecili Macián-Romero, Elías Guillem-Hernández, Celedonia Igual-Camacho
OBJECTIVE: The aim of the study was to analyze the effects of endurance and high-impact training oriented toward preventing osteoporosis in postmenopausal women with calcium and vitamin D supplementation. METHODS: This study was a randomized clinical trial. Thirty-six postmenopausal women were randomized to the control and experimental groups. Thirty-four women completed the 2-year interventions. The control group training involved walking at an intense pace. The experimental group conducted high-impact training specifically oriented to prevent osteoporosis...
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29039808/a-diagnosis-of-denial-how-mental-health-classification-systems-have-struggled-to-recognise-family-violence-as-a-serious-risk-factor-in-the-development-of-mental-health-issues-for-infants-children-adolescents-and-adults
#13
Wendy Bunston, Candice Franich-Ray, Sara Tatlow
Child and adolescent mental health services (CAMHS) routinely overlook assessing for, and providing treatment to, infants and children living with family violence, despite family violence being declared endemic across the globe. As contemporary neuro-developmental research recognises the harm of being exposed to early relational trauma, key international diagnostic texts such as the DSM-5 and ICD-10 struggle to acknowledge or appreciate the relational complexities inherent in addressing family violence and its impacts during childhood...
October 17, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29039261/one-year-follow-up-of-the-capo-kids-trial-are-physical-benefits-maintained
#14
Rossana C Nogueira, Benjamin K Weeks, Belinda Beck
PURPOSE: To determine the 12-month maintenance of a 9-month, thrice-weekly, 10-minute high-intensity exercise program, delivered in schools, on bone and other health-related performance variables in prepubertal children. METHODS: All participants (N = 311) of the CAPO kids trial (testing times T1-T2) were contacted to undergo retesting (T3) of all original measures-including weight, standing and sitting height, calcaneal broadband ultrasound attenuation (Achilles, GE), and stiffness index (Achilles, GE)-waist circumference, resting heart rate, blood pressure, vertical jump, and aerobic capacity...
October 17, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/29038420/effects-of-different-training-loads-on-emotional-state-and-mrna-and-protein-expressions-of-n-methyl-d-aspartate-receptor-subunits-postsynaptic-density-95-and-kinesin-family-member-17-in-hippocampus-of-rats
#15
Hefei Ren, Xinyi Yu, Liren Yu, Yinguo Zhang, Hong Xie, Na Shi, Lijun Chen
BACKGROUND Emotional state can be affected by different training loads. The aim of this study was to explore the changes of rat emotional state, as well as the mRNA and protein expressions of N-methyl-D-aspartate receptors (NMDARs), postsynaptic density 95 (PSD-95), and kinesin family member 17 (KIF-17) in the hippocampus, by long-term moderate-intensity and high-intensity training models in rats. MATERIAL AND METHODS The exercise model of SD rats was set up by treadmill running of moderate and high intensities for 4 weeks...
October 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29038351/differences-in-oxidative-metabolism-modulation-induced-by-ischemia-reperfusion-between-trained-and-untrained-individuals-assessed-by-nirs
#16
Rogério N Soares, Kaitlin M McLay, Mitchell A George, Juan M Murias
Endurance training is associated with skeletal muscle adaptations that regulate the oxidative metabolism during ischemia/reperfusion. The aim of this study was to noninvasively assess in vivo differences in the oxidative metabolism activity during ischemia/reperfusion between trained and untrained individuals, using near infrared spectroscopy (NIRS) combined with a vascular occlusion test (VOT) technique (NIRS-VOT). Sixteen untrained (26.3 ± 5.1 year) and seventeen trained (29.4 ± 4.9 year) healthy young adult men were submitted to a VOT (2 min baseline, 5 min occlusion, and 8 min reperfusion)...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29037629/electromyographic-activities-of-the-abdominal-muscles-during-30-and-75-of-maximum-expiratory-pressure
#17
Hiroshi Ishida, Mai Fujisawa, Ryo Yokoyama, Tadanobu Suehiro, Susumu Watanabe
The aim of this study was to quantify the activities of the rectus abdominis (RA), external oblique (EO), and internal oblique (IO) muscles during 30% and 75% of maximum expiratory pressure (PE max). Fifteen healthy male university students participated in this study. Electromyographic (EMG) activities of the RA, EO, and IO muscles were measured during 30% and 75% of PE max and then normalized relative to maximum voluntary contractions (%MVC). All muscles during 75% of PE max showed significantly higher %MVC compared to that during 30% of PE max (P < 0...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037403/analytical-expressions-for-estimating-endurance-time-and-glove-thermal-resistance-related-to-human-finger-in-cold-conditions
#18
Amir Fallahi, Mohammad Reza Salimpour, Ebrahim Shirani
Frostbite is considered the severest form of cold injury and can lead to necrosis and loss of peripheral appendages. Therefore, prediction of endurance time of limb's tissue in cold condition is not only necessary but also crucial to estimate cold injury intensity and to choose appropriate clothing. According to the previous work which applied a 3-D thermal model for human finger to analyze cold stress, in this study, an expression is presented for endurance time in cold conditions to prevent cold injury. A formula is also recommended to select a proper glove with specific thermal resistance based on the ambient situation and cold exposure time...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29036848/concentration-endurance-test-d2-normative-data-for-spanish-speaking-pediatric-population
#19
D Rivera, C Salinas, D Ramos-Usuga, I D Delgado-Mejía, Y Vasallo Key, G P Hernández Agurcia, J Valencia Vásquez, C E García-Guerrero, C García de la Cadena, B V Rabago Barajas, I Romero-García, A I Campos Varillas, M Sánchez-SanSegundo, A Galvao-Carmona, L Lara, E J Granja Gilbert, P Martín-Lobo, J Velázquez-Cardoso, A Caracuel, J C Arango-Lasprilla
OBJECTIVE: To generate normative data for the Concentration Endurance Test (d2) test in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the d2 test as part of a larger neuropsychological battery. The Total number of items processed (TN), Total number of correct responses (CR), Total performance (TP), and Concentration performance (CP) scores were normed using multiple linear regressions and standard deviations of residual values...
October 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036763/effect-of-treadmill-exercise-on-skeletal-muscle-autophagy-in-rats-with-obesity-induced-by-a-high-fat-diet
#20
Do Keun Cho, Dong Hun Choi, Joon Yong Cho
PURPOSE: This study aimed to investigate the effects of treadmill exercise on body weight, blood biochemistry, and autophagy. METHODS: Triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin, and glucose levels were measured, the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score was calculated, and the soleus muscle was analyzed for autophagy-related factors (Beclin-1, p62, LC3, Lamp-2) in rats with obesity induced by a high-fat diet...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
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