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https://www.readbyqxmd.com/read/29228079/effect-of-high-intensity-treadmill-exercise-on-motor-symptoms-in-patients-with-de-novo-parkinson-disease-a-phase-2-randomized-clinical-trial
#1
Margaret Schenkman, Charity G Moore, Wendy M Kohrt, Deborah A Hall, Anthony Delitto, Cynthia L Comella, Deborah A Josbeno, Cory L Christiansen, Brian D Berman, Benzi M Kluger, Edward L Melanson, Samay Jain, Julie A Robichaud, Cynthia Poon, Daniel M Corcos
Importance: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. Objectives: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on motor symptoms warrants a phase 3 trial. Design, Setting, and Participants: The Study in Parkinson Disease of Exercise (SPARX) was a phase 2, multicenter randomized clinical trial with 3 groups and masked assessors...
December 11, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29226572/nitroglycerin-and-the-enduring-principles-of-coronary-procedures
#2
EDITORIAL
On Topaz
The benefits of nitroglycerin are numerous, from ensuring accurate interpretation of diagnostic angiograms to treatment of coronary spasm and support of PCIs in simple or complex lesion types. The founders of the field were convinced that no coronary arteriography should be considered complete unless a vasodilator is used at some point during the study. This recommendation is valid. The guidelines should change to include administration of intracoronary nitroglycerin.
December 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29226053/compression-stockings-and-pressure-ulcers-case-series-of-a-neglected-issue
#3
Farooq A Rathore, Faria Ahmad, Omer J Khan
Pressure ulcers develop in patients who endure long periods of immobilization, often caused by conditions such as musculoskeletal and neurological diseases. Pressure ulcers adversely affect the patient and increase caregiver burden and healthcare costs. Typical sites for these ulcers include the sacrum, trochanters, and heels; they also occur on the nape of the neck, penis, nostrils, helix of the ear, and upper back. Compression stockings are commonly used to prevent and stop the progression of venous disorders, including deep vein thrombosis, but their role in the development of pressure ulcers is not well known...
October 10, 2017: Curēus
https://www.readbyqxmd.com/read/29225933/changing-views-on-child-mortality-and-economic-sanctions-in-iraq-a-history-of-lies-damned-lies-and-statistics
#4
REVIEW
Tim Dyson, Valeria Cetorelli
In August 1990, Saddam Hussein's army invaded Kuwait and consequently the United Nations imposed economic sanctions on Iraq. In 1991, an international military alliance expelled the Iraqi army from Kuwait during a short war. Nevertheless, the economic sanctions remained in place-their removal required that Iraq should destroy its weapons of mass destruction. Subsequent years saw reports of acute suffering in Iraq. The sanctions undoubtedly greatly reduced the country's ability to import supplies of food and medicine...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225820/iron-therapy-in-heart-failure-patients-without-anaemia-possible-implications-for-chronic-kidney-disease-patients
#5
REVIEW
Jolanta Malyszko, Stefan D Anker
Iron deficiency anaemia is a global health problem that manifests as fatigue and poor physical endurance. Anaemia can be caused by dietary iron deficiency, blood loss or a combination of poor iron absorption and ineffective iron mobilization in patients with chronic disease. Nephrologists caring for patients with impaired renal function understand that iron treatment is necessary to provide adequate iron for erythropoiesis during the treatment of overt anaemia. However, a less well-understood health problem is iron deficiency, which creates symptoms that overlap with those of anaemia and often occurs in concert with chronic disease...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225469/pelvic-vein-incompetence-clinical-perspectives
#6
REVIEW
David M Riding, Vivak Hansrani, Charles McCollum
Chronic pelvic pain (CPP) affects 24% of premenopausal women, accounts for 20%-30% of UK gynecology outpatient appointments, and has an annual pan-European economic cost of €3.8 billion. Despite extensive investigation, often including laparoscopy, up to 55% of women do not receive a diagnosis and endure persistent symptoms. In these patients, clinical management focuses on symptom control rather than treatment. It is possible that pelvic vein incompetence (PVI) is a cause of CPP, although the quality of studies investigating an association is generally low...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29225371/breaking-the-prejudice-habit-mechanisms-timecourse-and-longevity
#7
Patrick S Forscher, Chelsea Mitamura, Emily L Dix, William T L Cox, Patricia G Devine
The prejudice habit-breaking intervention (Devine et al., 2012) and its offshoots (e.g., Carnes et al., 2012) have shown promise in effecting long-term change in key outcomes related to intergroup bias, including increases in awareness, concern about discrimination, and, in one study, long-term decreases in implicit bias. This intervention is based on the premise that unintentional bias is like a habit that can be broken with sufficient motivation, awareness, and effort. We conducted replication of the original habit-breaking intervention experiment in a sample more than three times the size of the original (N = 292)...
September 2017: Journal of Experimental Social Psychology
https://www.readbyqxmd.com/read/29225311/inhibition-of-oxidative-stress-by-antioxidant-supplementation-does-not-limit-muscle-mitochondrial-biogenesis-or-endurance-capacity-in-rats
#8
Jae Cheol Kim, Gi Duck Park, Sang Hyun Kim
The objective of the present study was to analyze the activation and expression patterns of upstream and downstream factors of PGC-1α to determine whether antioxidant (AO) supplementation inhibits mitochondrial biogenesis in skeletal muscles as an adaptation to endurance training, as well as to analyze changes in endurance capacity based on such findings. For this objective, 24 male Sprague-Dawley (SD) rats were allocated into 4 groups (vehicle-sedentary, V-Sed; vehicle-exercise, V-EX; antioxidant-sedentary, AO-Sed; antioxidant-exercise, AO-EX) of 6 rats each...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29224960/persons-with-secondary-progressive-and-relapsing-remitting-multiple-sclerosis-reveal-different-responses-of-tryptophan-metabolism-to-acute-endurance-exercise-and-training
#9
Jens Bansi, Christina Koliamitra, Wilhelm Bloch, Niklas Joisten, Alexander Schenk, Matthew Watson, Jan Kool, Dawn Langdon, Ulrik Dalgas, Jürg Kesselring, Philipp Zimmer
Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((RRMS) n=33) and secondary progressive ((SPMS) n=24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with RRMS...
December 6, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29224501/experimental-validation-of-a-subject-specific-maximum-endurance-time-model
#10
Bin Liu, Liang Ma, Chi Chen, Zhanwu Zhang
This study aimed at experimentally validating a subject-specific maximum endurance time (MET) model. Thirty health participants (15 males and 15 females; Age: mean = 21.5 years, SD = 1.6 years) volunteered to conduct an isometric elbow flexion task until exhaustion. The endurance times of each participant were measured under relative exertion levels ranging from 30%MVC (Maximum Voluntary Contraction) to 70%MVC at 10% intervals. Assessment of the model showed that the intensity-endurance time relationship for each studied individual could be well fitted by the subject-specific MET model (R2 > 0...
December 9, 2017: Ergonomics
https://www.readbyqxmd.com/read/29224235/long-term-cardiovascular-re-programming-by-short-term-perinatal-exposure-to-nicotine-s-main-metabolite-cotinine
#11
Stefano Bastianini, Viviana Lo Martire, Alessandro Silvani, Giovanna Zoccoli, Chiara Berteotti, Hugo Lagercrantz, Anders Arner, Gary Cohen
AIM: Gather "proof-of-concept" evidence of the adverse developmental potential of cotinine (a seemingly benign biomarker of recent nicotine / tobacco smoke exposure). METHODS: Pregnant C57 mice drank nicotine or cotinine-laced water for 6wks from conception (NPRE = 2% saccharin+100μg nicotine/ml; CPRE = 2% saccharin + 10μg cotinine/ml) or 3wks after birth (CPOST = 2% saccharin + 30μg cotinine/ml). Controls drank 2% saccharin (CTRL). At 17±1weeks (male pups; CTRL n=6; CPOST n=6; CPRE n=8; NPRE n=9) we assessed (i) cardiovascular control during sleep; (ii) arterial reactivity ex vivo; (iii) expression of genes involved in arterial constriction / dilation...
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29223353/late-open-surgical-conversion-after-endovascular-abdominal-aortic-aneurysm-repair
#12
Vinay Kansal, Sudhir Nagpal, Prasad Jetty
INTRODUCTION: Late open surgical conversion following endovascular aneurysm repair (EVAR) may occur more frequently after performing EVAR in anatomy outside the instructions for use (IFU). This study reviews predictors and outcomes of late open surgical conversion for failed EVAR. METHODS: This retrospective cohort study reviewed all EVARs performed at the Ottawa Hospital between January 1999 and May 2015. Open surgical conversions >1 month post EVAR were identified...
December 6, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29222470/remote-control-of-resistive-switching-in-tio2-based-resistive-random-access-memory-device
#13
Dwipak Prasad Sahu, S Narayana Jammalamadaka
We report on the magnetic field control of a bipolar resistive switching in Ag/TiO2/FTO based resistive random access memory device through I-V characteristics. Essentially, in the presence of magnetic field and in the low resistance state, an abrupt change in the resistance of the device demands higher voltage, hinting that residual Lorentz force plays a significant role in controlling the resistance state. Endurance characteristics of the device infer that there is no degradation of the device even after repeated cycling, which ensures that the switching of resistance between 'off' and 'on' states is reproducible, reversible and controllable...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221898/exercise-merging-physical-and-cognitive-stimulation-improves-physical-fitness-and-cognitive-functioning-in-older-nursing-home-residents-a-pilot-study
#14
José Marmeleira, Luís Galhardas, Armando Raimundo
The main purpose of this pilot study was to examine the feasibility and the effects of a multimodal exercise intervention on the physical and cognitive functioning of institutionalized older people. Twenty-one older adults (83.5 ± 4.9 years) living in two nursing home residences, were tested on two occasions 4 weeks apart to establish a baseline measure, and then engage in the exercise program twice weekly for 8 weeks. Participants were tested again after the exercise program. Almost all physical fitness and cognitive tests were unchanged at baseline measures, but after the exercise program, significant improvements (p < 0...
December 5, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29221655/impact-of-interleukin-6-and-interleukin-10-serum-levels-and-mrna-expression-level-on-polytrauma-patients
#15
Heber B Sapan, Idrus Paturusi, Andi Asadul Islam, Irawan Yusuf, Ilhamjaya Patellongi, Muhammmad Nasrum Massi, Aryono D Pusponegoro, Syafrie K Arief, Ibrahim Labeda, Leo Rendy, Mochammad Hatta
INTRODUCTION: Host response to polytrauma occasionally has unpredictable outcomes. Immune response is a major factor influencing patient's outcome. This study evaluated the interaction of two main cytokines in immune response after major trauma, specifically interleukin-6 (IL-6) and interleukin-10 (IL-10) in which their serum level comes from the mRNA expression of these cytokine genes and outcome of polytrauma patients. METHODS: This prospective multicenter trial held at four trauma centers enrolled 54 polytrauma patients [Injury Severity Score (ISS) ≥ 16]...
November 4, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29220541/yoga-for-stroke-rehabilitation
#16
REVIEW
Maggie Lawrence, Francisco T Celestino Junior, Hemilianna Hs Matozinho, Lindsay Govan, Jo Booth, Jane Beecher
BACKGROUND: Stroke is a major health issue and cause of long-term disability and has a major emotional and socioeconomic impact. There is a need to explore options for long-term sustainable interventions that support stroke survivors to engage in meaningful activities to address life challenges after stroke. Rehabilitation focuses on recovery of function and cognition to the maximum level achievable, and may include a wide range of complementary strategies including yoga.Yoga is a mind-body practice that originated in India, and which has become increasingly widespread in the Western world...
December 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29219843/negative-differential-resistance-effect-induced-by-metal-ion-implantation-in-sio-sub-2-sub-film-for-multilevel-rram-application
#17
Facai Wu, Shuyao Si, Tuo Shi, Xiaolong Zhao, Qi Liu, Lei Liao, Hangbing Lv, Shibing Long, Ming Liu
Pt/SiO<sub>2</sub>:metal nanoparticles (MNPs)/Pt sandwich structure is fabricated with the method of metal ion (Ag) implantation. The device exhibits multilevel storage with appropriate R<sub>off</sub>/R<sub>on</sub> ratio, good endurance and retention properties. Based on transmission electron microscopy (TEM) and energy dispersive spectrometer (EDS) analysis, we confirm that Pt nanoparticles are spurted into SiO<sub>2 </sub>film from Pt bottom electrode by Ag implantation; during electroforming, the local electric field can be enhanced by these Pt nanoparticles, meanwhile the Ag nanoparticles constantly migrate toward the Pt nanoparticles...
December 8, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29217682/overexpression-of-the-histone-dimethyltransferase-g9a-in-nucleus-accumbens-shell-increases-cocaine-self-administration-stress-induced-reinstatement-and-anxiety
#18
Ethan M Anderson, Erin B Larson, Daniel Guzman, Anne Marie Wissman, Rachael L Neve, Eric J Nestler, David W Self
Repeated exposure to cocaine induces lasting epigenetic changes in neurons that promote the development and persistence of addiction. One epigenetic alteration involves reductions in levels of the histone dimethyltransferase, G9a, in nucleus accumbens (NAc) after chronic cocaine administration. This reduction in G9a may enhance cocaine reward since overexpressing G9a in the NAc decreases cocaine-conditioned place preference. Thus, we hypothesized that HSV-mediated G9a overexpression in the NAc shell (NAcSh) would attenuate cocaine self-administration and cocaine-seeking behavior...
December 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29217665/critical-determinants-of-combined-sprint-and-endurance-performance-an-integrative-analysis-from-muscle-fiber-to-the-human-body
#19
Stephan van der Zwaard, Willem J van der Laarse, Guido Weide, Frank W Bloemers, Mathijs J Hofmijster, Koen Levels, Dionne A Noordhof, Jos J de Koning, Cornelis J de Ruiter, Richard T Jaspers
Optimizing physical performance is a major goal in current physiology. However, basic understanding of combining high sprint and endurance performance is currently lacking. This study identifies critical determinants of combined sprint and endurance performance using multiple regression analyses of physiologic determinants at different biologic levels. Cyclists, including 6 international sprint, 8 team pursuit, and 14 road cyclists, completed a Wingate test and 15-km time trial to obtain sprint and endurance performance results, respectively...
December 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29215602/proteomic-contributions-to-medicinal-plant-research-from-plant-metabolism-to-pharmacological-action
#20
REVIEW
Akiko Hashiguchi, Jingkui Tian, Setsuko Komatsu
Herbal medicine is a clinical practice of utilizing medicinal plant derivatives for therapeutic purposes. It has an enduring history worldwide and plays a significant role in the fight against various diseases. Herbal drug combinations often exhibit synergistic therapeutic action compared with single-constituent dosage, and can also enhance the cytotoxicity induced by chemotherapeutic drugs. To explore the mechanism underlying the pharmacological action of herbs, proteomic approaches have been applied to the physiology of medicinal plants and its effects on animals...
December 7, 2017: Proteomes
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