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https://www.readbyqxmd.com/read/29351687/intraoperative-transpedicular-onyx-injection-to-reduce-vascularity-of-a-thoracic-hemangiopericytoma-after-unsuccessful-preoperative-endovascular-embolization-a-technical-report
#1
Hazem Mashaly, Zoe Zhang, Andrew Shaw, Patrick Youssef, Ehud Mendel
BACKGROUND AND IMPORTANCE: Hemangiopericytoma is a rare vascular tumor with central nervous system involvement representing only 1% of central nervous system tumors. They rarely affect the vertebral column. Complete surgical resection is the treatment of choice for hemangiopericytoma given their high rates of local recurrence. However, the high vascularity of such tumors with the risk of massive bleeding during surgery represents a significant challenge to surgeons. Therefore, preoperative endovascular embolization via the transarterial route has been advocated...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351637/prospective-multicenter-assessment-of-all-cause-mortality-following-surgery-for-adult-cervical-deformity
#2
Justin S Smith, Christopher I Shaffrey, Han Jo Kim, Peter Passias, Themistocles Protopsaltis, Renaud Lafage, Gregory M Mundis, Eric Klineberg, Virginie Lafage, Frank J Schwab, Justin K Scheer, Emily Miller, Michael Kelly, D Kojo Hamilton, Munish Gupta, Vedat Deviren, Richard Hostin, Todd Albert, K Daniel Riew, Robert Hart, Doug Burton, Shay Bess, Christopher P Ames
BACKGROUND: Surgical treatments for adult cervical spinal deformity (ACSD) are often complex and have high complication rates. OBJECTIVE: To assess all-cause mortality following ACSD surgery. METHODS: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Clinical and surgical parameters and all-cause mortality were assessed. RESULTS: Of 123 ACSD patients, 120 (98%) had complete baseline data (mean age, 60...
January 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29351247/b-type-and-complex-a-b-type-epicatechin-trimers-isolated-from-litchi-pericarp-aqueous-extract-show-high-antioxidant-and-anticancer-activity
#3
Yihui Gong, Fang Fang, Xin Zhang, Bin Liu, Honghui Luo, Zhen Li, Xuelian Zhang, Zhaoqi Zhang, Xuequn Pang
Litchi (Litchi chinensis Sonn.) fruit is known for its rich source of phenolics. Litchi pericarp contains high levels of epicatechin that may form oligomers of various lengths. Except for several A or B type epicatechin dimers, other soluble oligomers have rarely been identified in the pericarp. Here, bioassay-guided column fractionation was applied to isolate bioactive phenolics from aqueous pericarp extract. A fraction (S3) was obtained by two rounds of Sephadex LH-20 column chromatography, and showed higher antioxidant activity and inhibition on the proliferation of human lung cancer cells (A549) than Litchi anthocyanins...
January 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29351200/comparing-nutrient-removal-from-membrane-filtered-and-unfiltered-domestic-wastewater-using-chlorella-vulgaris
#4
Elyssia Mayhead, Alla Silkina, Carole A Llewellyn, Claudio Fuentes-Grünewald
The nutrient removal efficiency of Chlorella vulgaris cultivated in domestic wastewater was investigated, along with the potential to use membrane filtration as a pre-treatment tool during the wastewater treatment process. Chlorella vulgaris was batch cultivated for 12 days in a bubble column system with two different wastewater treatments. Maximum uptake of 94.18% ammonium (NH₄-N) and 97.69% ortho-phosphate (PO₄-P) occurred in 0.2 μm membrane filtered primary wastewater. Membrane filtration enhanced the nutrient uptake performance of C...
January 19, 2018: Biology
https://www.readbyqxmd.com/read/29351174/the-evolving-science-of-patient-and-family-engagement-an-interview-with-dr-karen-drenkard
#5
Patricia Reid-Ponte
Patient- and family-centered care is a central tenet of nursing practice. This concept has evolved to include patient partnerships, patient engagement, and patient activation. This column differentiates these concepts and describes the core principles embedded in the overriding intention of ensuring that patients (and their families or significant others) are orchestrators of their health and their care plans. In this interview, Karen Drenkard, PhD, RN, FAAN, NEA-BC, CNO, of the GetWellNetwork, discusses work by the O'Neil Center as a leader in this area...
February 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29350685/re-orchestration-of-blood-flow-by-micro-circulations
#6
P A R Meyer
Haemoglobin Video Imaging (HVI) demonstrates conjunctival and episcleral blood flow in man with the resolution of a single erythrocyte. A new method for establishing vessel hierarchy in micro-circulations is described, which recognises either delivery or drainage vessels and references vessel order to the capillary. These tools have been used to characterise blood flow.Anterior ciliary arteries show pulsatile variation in diameter. The episcleral arterial circle that they supply has functional apices with pulsatile flow reversal...
January 19, 2018: Eye
https://www.readbyqxmd.com/read/29350594/determinants-of-perioperative-transfusion-risk-in-patients-with-adult-spinal-deformity
#7
Varun Puvanesarajah, Sandesh S Rao, Hamid Hassanzadeh, Khaled M Kebaish
OBJECTIVE To determine predictors of perioperative allogeneic packed red blood cell (pRBC) transfusion requirement (total units transfused) in patients with adult spinal deformity (ASD). METHODS The authors retrospectively analyzed records of patients aged 18 years or older who underwent surgical correction of ASD that involved 4 or more spinal levels by the same spine surgeon between 2010 and 2016. Data regarding patient characteristics, comorbidities, surgical factors, and perioperative transfusions (up to 10 days after surgery) were analyzed using a linear regression model...
January 19, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29350313/immobilization-of-methylosinus-trichosporium-ob3b-for-methanol-production
#8
Anne Taylor, Paige Molzahn, Tanner Bushnell, Clint Cheney, Monique LaJeunesse, Mohamad Azizian, Lewis Semprini
Due to the natural gas boom in North America, there is renewed interest in the production of other chemical products from methane. We investigated the feasibility of immobilizing the obligate methanotrophic bacterium Methylosinus trichosporium OB3b in alginate beads, and selectively inactivating methanol dehydrogenase (MDH) with cyclopropane to produce methanol. In batch cultures and in semi-continuous flow columns, the exposure of alginate-immobilized cells to cyclopropane or cyclopropanol resulted in the loss of the majority of MDH activity (> 80%), allowing methanol to accumulate to significant concentrations while retaining all of M...
January 19, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29350256/analysis-of-phenolic-compounds-in-different-parts-of-pomegranate-punica-granatum-fruit-by-hplc-pda-esi-ms-and-evaluation-of-their-antioxidant-activity-application-to-different-italian-varieties
#9
Marina Russo, Chiara Fanali, Giusy Tripodo, Paola Dugo, Rosario Muleo, Laura Dugo, Laura De Gara, Luigi Mondello
The analysis of pomegranate phenolic compounds belonging to different classes in different fruit parts was performed by high-performance liquid chromatography coupled with photodiode array and mass spectrometry detection. Two different separation methods were optimized for the analysis of anthocyanins and hydrolyzable tannins along with phenolic acids and flavonoids. Two C18 columns, core-shell and fully porous particle stationary phases, were used. The parameters for separation of phenolic compounds were optimized considering chromatographic resolution and analysis time...
January 19, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29349799/simultaneous-lc-ms-ms-bioanalysis-of-etoposide-and-paclitaxel-in-mouse-tissues-and-plasma-after-oral-administration-of-self-microemulsifying-drug-delivery-systems
#10
Dan Li, Gang Zhao, Weipeng Ai, Gao Li, Luqin Si, Jiangeng Huang, Yunzhou Chen, Sanlan Wu
In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determine the anticancer drugs etoposide and paclitaxel in mouse plasma and tissues including liver, kidney, lung, heart, spleen and brain. The analytes were extracted from the matrices of interest by liquid-liquid extraction using DCM: MTBE (1:1, v/v). Chromatographic separation was achieved on an Ultimate XB-C18 column (100 mm × 2.1 mm, 3 μm) at 40 °C and the total run time was 4 min under a gradient elution...
January 19, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29349790/identification-of-the-absorbed-components-and-metabolites-of-modified-huo-luo-xiao-ling-dan-in-rat-plasma-by-uhplc-q-tof-ms-ms
#11
Nannan Wang, Xiaoning Zhao, Yiran Li, Congcong Cheng, Jiaxin Huai, Kaishun Bi, Ronghua Dai
To reveal the material basis of Huo Luo Xiao Ling Dan, a sensitive and selective ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) method was developed to identify the absorbed components and metabolites in rat plasma after oral administration of HLXLD. The plasma samples were pretreated by liquid-liquid extraction and separated on a Shim-pack XR-ODS C18 column (75 mm × 3.0 mm, 2.2 μm) using a gradient elution program. With the optimized conditions and single sample injection of each positive or negative ion mode, a total of 109 compounds, including 78 prototype compounds and 31 metabolites were identified or tentatively characterized...
January 19, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29349685/solute-transport-in-the-bone-lacunar-canalicular-system-lcs
#12
REVIEW
Liyun Wang
PURPOSE OF REVIEW: Solute transport in the lacunar-canalicular system (LCS) plays important roles in osteocyte metabolism and cell-cell signaling. This review will summarize recent studies that establish pericellular matrix (PCM), discovered inside the LCS, as a crucial regulator of solute transport in bone. RECENT FINDINGS: Utilizing confocal imaging and mathematical modeling, recent studies successfully quantified molecular diffusion and convection in the LCS as well as the size-dependent sieving effects of the PCM, leading to the quantification of the effective PCM fiber spacing (10 to 17 nm) in murine adult bones...
January 18, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29349621/adsorption-and-leaching-of-novel-fungicide-pyraoxystrobin-on-soils-by-14c-tracing-method
#13
Xunyue Liu, Huiming Wu, Tingting Hu, Xia Chen, Xingcheng Ding
Pyraoxystrobin, (E)-2-(2-((3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-yloxy)methyl)phenyl)-3-methoxyacrylate, is a newly developed strobilurin fungicide with high antifungal efficiency. It has high potential to enter soil environments that might subsequently impact surface and groundwater. Therefore, 14C-labeled pyraoxystrobin was used as a tracer to study the adsorption/desorption and migration behavior of this compound under laboratory conditions in three typical agricultural soils. The adsorption isotherms conformed with the Freundlich equation...
January 19, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29349097/universal-method-for-the-purification-of-recombinant-aav-vectors-of-differing-serotypes
#14
Shelley A Nass, Maryellen A Mattingly, Denise A Woodcock, Brenda L Burnham, Jeffrey A Ardinger, Shayla E Osmond, Amy M Frederick, Abraham Scaria, Seng H Cheng, Catherine R O'Riordan
The generation of clinical good manufacturing practices (GMP)-grade adeno-associated virus (AAV) vectors requires purification strategies that support the generation of vectors of high purity, and that exhibit a good safety and efficacy profile. To date, most reported purification schemas are serotype dependent, requiring method development for each AAV gene therapy product. Here, we describe a platform purification process that is compatible with the purification of multiple AAV serotypes. The method generates vector preparations of high purity that are enriched for capsids with full vector genomes, and that minimizes the fractional content of empty capsids...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29348363/atomic-resolution-transmission-electron-microscopy-of-electron-beam-sensitive-crystalline-materials
#15
Daliang Zhang, Yihan Zhu, Lingmei Liu, Xiangrong Ying, Chia-En Hsiung, Rachid Sougrat, Kun Li, Yu Han
High-resolution imaging of electron beam-sensitive materials is one of the most difficult applications of transmission electron microscopy (TEM). The challenges are manifold, including the acquisition of images with extremely low beam doses, the time-constrained search for crystal zone axes, the precise image alignment, and the accurate determination of the defocus value. We develop a suite of methods to fulfill these requirements and acquire atomic-resolution TEM images of several metal organic frameworks that are generally recognized as highly sensitive to electron beams...
January 18, 2018: Science
https://www.readbyqxmd.com/read/29348108/report-fast-chromatographic-screening-method-for-7-drugs-of-potential-threat-in-drug-facilitated-crimes
#16
Beril Anılanmert, Ibrahim Narın, Ibrahim Aydın, Munevver Acıkkol
In cases where pharmaceuticals and pharmaceutical candidates are involved in drug facilitated crimes (DFC), like organ theft, robbery, rape and suicides, the analysis of drug powders or solution residues found in crime scenes may give idea on what the victims have ingested. An easy and fast simultaneous determination of 7 drugs; GHB (γ-hydroxybutyrate), GBL (γ-butyrolactone), norketamine, ketamine, fenobarbital, fenitoin and thiopental which have the potential to be used in DFC was performed. The method required no sample preparation and has 12 minutes elution time with a good chromatographic separation...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29348095/estimation-of-simvastatin-and-cetirizine-by-rp-lc-method-application-to-freeze-and-thaw-ft-stability-studies
#17
Safila Naveed, Khan Usmanghani, Aisha Sana, Huma Ali, Farya Zafar, Fatima Qamar, Ghulam Sarwer, Sarah Abbas, M Tanweer Alam, Muhammad Ibrar Shinwari
Sensitive, simple, reliable and rapid HPLC technique for the estimation of simvastatin (SMV) and cetirizine has been designed in this study. The chromatographic conditions were set using Shimadzu LC-10 AT VP pump, with UV detector (SPD-10 AV-VP). System integration was performed with CBM-102 (Bus Module). Partitioning of components was attained with pre-packed C-18 column of Purospher Star (5 μm, 250 x 4.6 mm) at ambient conditions. Injected volume of sample was 10 μl. Mobile phase was composed of 50:50 v/v ratio of Acetonitrile/water (pH 3...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29347910/getting-messier-with-tidier-embracing-context-and-complexity-in-intervention-reporting
#18
Sarah Cotterill, Sarah Knowles, Anne-Marie Martindale, Rebecca Elvey, Susan Howard, Nia Coupe, Paul Wilson, Michael Spence
BACKGROUND: The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is now widely used in health research. The aim of this paper is to describe the experience of using TIDieR outside of trials, in a range of applied health research contexts, and make recommendations on its usefulness in such settings. MAIN BODY: We used the TIDieR template for intervention description in six applied health research projects...
January 18, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29347623/origin-of-the-inertial-deviation-from-darcy-s-law-an-investigation-from-a-microscopic-flow-analysis-on-two-dimensional-model-structures
#19
Mehrez Agnaou, Didier Lasseux, Azita Ahmadi
Inertial flow in porous media occurs in many situations of practical relevance among which one can cite flows in column reactors, in filters, in aquifers, or near wells for hydrocarbon recovery. It is characterized by a deviation from Darcy's law that leads to a nonlinear relationship between the pressure drop and the filtration velocity. In this work, this deviation, also known as the nonlinear, inertial, correction to Darcy's law, which is subject to controversy upon its origin and dependence on the filtration velocity, is studied through numerical simulations...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347599/energy-decay-in-a-tapped-granular-column-can-a-one-dimensional-toy-model-provide-insight-into-fully-three-dimensional-systems
#20
C R K Windows-Yule, D L Blackmore, A D Rosato
The decay of energy within particulate media subjected to an impulse is an issue of significant scientific interest, but also one with numerous important practical applications. In this paper, we study the dynamics of a granular system exposed to energetic impulses in the form of discrete taps from a solid surface. By considering a one-dimensional toy system, we develop a simple theory, which successfully describes the energy decay within the system following exposure to an impulse. We then extend this theory so as to make it applicable also to more realistic, three-dimensional granular systems, assessing the validity of the model through direct comparison with discrete particle method simulations...
October 2017: Physical Review. E
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