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https://www.readbyqxmd.com/read/28743076/lc-ms-ms-esi-method-for-simultaneous-quantification-of-darolutamide-and-its-active-metabolite-orm-15341-in-mice-plasma-and-its-application-to-a-pharmacokinetic-study
#1
Sreekanth Dittakavi, Pavan Kumar V S P Nagasuri, Suresh P Sulochana, Syed Mohd Saim, Sadanand R Mallurwar, Mohd Zainuddin, Purushottam Dewang, Sriram Rajagopal, Ramesh Mullangi
A sensitive and rapid LC-MS/MS method was developed and validated for the simultaneous quantitation of darolutamide and its active metabolite i.e. ORM-15341 in 50μL mice plasma using bicalutamide as an internal standard (I.S.) as per regulatory guidelines. Sample processing was accomplished through liquid-liquid extraction. Chromatographic separation was achieved using an Atlantis C18 column with an isocratic mobile phase comprising 0.2% formic acid:acetonitrile (35:65, v/v) at a flow rate of 0.8mL/min within 2...
July 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28743065/enantiomerization-and-stereoselectivity-in-bioaccumulation-of-furalaxyl-in-tenebrio-molitor-larvae
#2
Jing Yin, Yongxin Gao, Feilong Zhu, Weiyu Hao, Qi Xu, Huili Wang, Baoyuan Guo
Furalaxyl is a chiral pesticide and widely used in modern agriculture as racemate mixture. The enantiomerization and enantioselecive bioaccumulation by a single dose of furalaxyl to Tenebrio molitor larvae under laboratory conditions were studied using a high-performance liquid chromatography tandem mass spectroscopy method based on a ChiralPAK IC column. Our results showed that a significant enantiomerization (interconversion between R-enantiomer and S-enantiomer) was observed in Tenebrio molitor larvae under R- or S-furalaxyl exposure...
July 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28743003/patterned-disordered-cell-motion-ensures-vertebral-column-symmetry
#3
Dipjyoti Das, Veena Chatti, Thierry Emonet, Scott A Holley
The biomechanics of posterior embryonic growth must be dynamically regulated to ensure bilateral symmetry of the spinal column. Throughout vertebrate trunk elongation, motile mesodermal progenitors undergo an order-to-disorder transition via an epithelial-to-mesenchymal transition and sort symmetrically into the left and right paraxial mesoderm. We combine theoretical modeling of cell migration in a tail-bud-like geometry with experimental data analysis to assess the importance of ordered and disordered cell motion...
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28742650/reliable-and-easy-to-use-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-analysis-of-fluconazole-isavuconazole-itraconazole-hydroxy-itraconazole-posaconazole-and-voriconazole-in-human-plasma-and-serum
#4
Carsten Müller, David Gehlen, Cornelia Blaich, Domenik Prozeller, Blasius Liss, Thomas Streichert, Martin H J Wiesen
BACKGROUND: A fast and easy-to-use liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination and quantification of six triazoles (fluconazole (FLZ), isavuconazole (ISZ), itraconazole (ITZ), hydroxy-itraconazole (OH-ITZ), posaconazole (PSZ), voriconazole (VRZ)) in human plasma and serum was developed and validated for therapeutic drug monitoring (TDM). METHODS: Sample preparation was based on protein precipitation with acetonitrile and subsequent centrifugation...
July 24, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28742288/supporting-and-empowering-direct-care-nurses-to-promote-ebp-an-example-of-evidence-based-policy-development-education-and-practice-change
#5
Amy Hagedorn Wonder, Emily K Martin, Kathryn Jackson
This column shares the best evidence-based strategies and innovative ideas on how to facilitate the learning and implementation of EBP principles and processes by clinicians as well as nursing and interprofessional students. Guidelines for submission are available at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1741-6787.
August 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28742059/spanning-the-scales-of-mechanical-metamaterials-using-time-domain-simulations-in-transformed-crystals-graphene-flakes-and-structured-soils
#6
Ronald Aznavourian, Tania Michelle Guenneau-Puvirajesinghe, Stephane Brule, Stefan Enoch, Sebastien Roger Guenneau
We begin with a brief historical survey of discoveries of quasi-crystals and graphene, and then introduce the concept of transformation crystallography, which consists of the application of geometric transforms to periodic structures. We consider motifs with three-fold, four-fold and six-fold symmetries according to the crystallographic restriction theorem. Furthermore, we define motifs with five-fold symmetry such as quasi-crystals generated by a cut-and-projection method from periodic structures in higher-dimensional space...
July 25, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28742038/understanding-symmetric-smoothing-filters-a-gaussian-mixture-model-perspective
#7
Stanley H Chan, Todd Zickler, Yue M Lu
Many patch-based image denoising algorithms can be formulated as applying a smoothing filter to the noisy image. Expressed as matrices, the smoothing filters must be row normalized so that each row sums to unity. Surprisingly, if we apply a column normalization before the row normalization, the performance of the smoothing filter can often be significantly improved. Prior works showed that such performance gain is related to the Sinkhorn-Knopp balancing algorithm, an iterative procedure that symmetrizes a row-stochastic matrix to a doublystochastic matrix...
July 24, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28741148/simultaneous-navigated-cervico-thoracic-and-thoraco-lumbar-fixation
#8
Krunal Patel, Tamara Tajsic, Karol P Budohoski, Mathew R Guilfoyle, Rikin A Trivedi
STUDY DESIGN: Case report. OBJECTIVE: To investigate the feasibility of using two independent image guidance systems to simultaneously fix multiple segment spine fractures. Image guidance is increasingly used to aid spinal fixation. We describe the first use of multiple navigation systems during a single procedure allowing for multi-segment spinal fixations to be performed simultaneously and capitalizing the advantages of navigation. METHOD: Two Medtronic Stealth Station S7™ systems with O-arm image capture were used to guide fixation of C6 and T12, unstable, AO A4, three-column fractures, in a patient with ankylosing spondylitis...
July 24, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28741108/automated-clean-up-separation-and-detection-of-polycyclic-aromatic-hydrocarbons-in-particulate-matter-extracts-using-a-2d-lc-2d-gc-system-a-method-translation-from-two-fids-to-two-ms-detectors
#9
Hwanmi Lim, Trifa M Ahmed, Christoffer Bergvall, Roger Westerholm
An online two-dimensional (2D) liquid chromatography/2D gas chromatography system with two mass-selective detectors has been developed on the basis of a previous system with two flame ionization detectors. The method translation involved the change of carrier gas from hydrogen to helium, column dimension and detectors. The 2D system with two mass-selective detectors was validated with use of polycyclic aromatic hydrocarbon (PAH) standards and two standard reference materials from air and diesel exhaust. Furthermore, the system was applied to a real sample, wood smoke particulates...
July 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28739527/deconstructing-the-cortical-column-in-the-barrel-cortex
#10
Kevin Fox
The question of what function is served by the cortical column has occupied neuroscientists since its original description some 60 years ago. The answer seems tractable in the somatosensory cortex when considering the inputs to the cortical column and the early stages of information processing, but quickly breaks down once the multiplicity of output streams and their sub-circuits are brought into consideration. This article describes the early stages of information processing in the barrel cortex, through generation of the centre and surround receptive field components of neurones that subserve integration of multi whisker information, before going on to consider the diversity of properties exhibited by the layer 5 output neurones...
July 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28739273/analysis-of-packing-microstructure-and-wall-effects-in-a-narrow-bore-ultrahigh-pressure-liquid-chromatography-column-using-focused-ion-beam-scanning-electron-microscopy
#11
Arved E Reising, Sabine Schlabach, Vasili Baranau, Daniela Stoeckel, Ulrich Tallarek
Column wall effects are well recognized as major limiting factor in achieving high separation efficiency in HPLC. This is especially important for modern analytical columns packed with small particles, where wall effects dominate the band broadening. Detailed knowledge about the packing microstructure of packed analytical columns has so far not been acquired. Here, we present the first three-dimensional reconstruction protocol for these columns utilizing focused ion-beam scanning electron microscopy (FIB-SEM) on a commercial 2...
July 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28739249/intraperitoneal-pressure-in-peritoneal-dialysis
#12
Vicente Pérez Díaz, Sandra Sanz Ballesteros, Esther Hernández García, Elena Descalzo Casado, Irene Herguedas Callejo, Cristina Ferrer Perales
The measure of intraperitoneal pressure in peritoneal dialysis is easy and provides clear therapeutic benefits. However it is measured only rarely in adult peritoneal dialysis units. This review aims to disseminate the usefulness of measuring intraperitoneal pressure. This measurement is performed in supine before initiating the drain of a manual exchange with "Y" system, by raising the drain bag and measuring from the mid-axillary line the height of the liquid column that rises from the patient. With typical values of 10-16 cmH2O, intraperitoneal pressure should never exceed 18 cmH2O...
July 21, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28738852/tertiary-syphilis-in-the-lumbar-spine-a-case-report
#13
Yang Bai, Feng Niu, Lidi Liu, Hui Sha, Yimei Wang, Song Zhao
BACKGROUND: The incidence of tertiary syphilis involvement in the spinal column with destructive bone lesions is very rare. It is difficult to establish the correct diagnosis from radiographs and histological examination alone. Limited data are available on surgical treatment to tertiary syphilitic spinal lesions. In this article, we report a case of tertiary syphilis in the lumbar spine with osteolytic lesions causing cauda equina compression. CASE PRESENTATION: A 44-year-old man who suffered with low back pain for 6 months and progressive radiating pain at lower extremity for 1 week...
July 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28738662/highly-efficient-enrichment-of-low-abundance-intact-proteins-by-core-shell-structured-fe3o4-chitosan-graphene-composites
#14
Peng Zhang, Xiaoni Fang, Guoquan Yan, Mingxia Gao, Xiangmin Zhang
In proteomics research, the screening and monitoring of disease biomarkers is still a major challenge, mainly due to their low concentration in biological samples. However, the universal enrichment of intact proteins has not been further studied. In this work, we developed a Fe3O4-chitosan@graphene (Fe3O4-CS@G) core-shell composite to enrich low-abundance proteins from biological samples. Fe3O4-CS@G composite holds chitosan layer decorated Fe3O4 core, which improves the hydrophilicity of materials greatly. Meanwhile, the graphene nanosheets shell formed via electrostatic assembly endows the composite with huge surface area (178m(2)/g)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738654/development-of-a-sensitive-and-quantitative-uhplc-ms-ms-method-to-study-the-whole-body-uptake-of-pharmaceuticals-in-zebrafish
#15
Stanislav Kislyuk, Jerome Kroonen, Erwin Adams, Patrick Augustijns, Peter de Witte, Deirdre Cabooter
An analytical procedure to measure the whole-body uptake of pharmaceuticals in zebrafish has been developed using state-of-the-art methodologies. A sample preparation procedure for 9 pharmaceuticals displaying a variety in physicochemical properties was developed using 10-day old zebrafish (TG898). For an efficient homogenization of the samples and subsequent recovery of the compounds of interest, different amounts of organic solvents in combination with acidic modifiers were added to zebrafish samples. Samples were subsequently processed using a powerful bath sonicator and centrifuged...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738646/synthesis-characterization-and-application-of-a-novel-multifunctional-stationary-phase-for-hydrophilic-interaction-reversed-phase-mixed-mode-chromatography
#16
Hayriye Aral, K Serdar Çelik, Ramazan Altındağ, Tarık Aral
A novel multifunctional stationary phase based on silica gel was synthesised starting from L- isoleucine and 4-phenylbutylamine and evaluated as a hydrophilic interaction/reversed-phase mixed-mode stationary phase for high-performance liquid chromatography (HPLC). The prepared stationary phase was characterized by elemental analysis, infrared spectroscopy (IR), scanning electron microscopy (SEM), Brunauer, Emmett and Teller (BET) and solid-state (13)C nuclear magnetic resonance (NMR). The mechanisms involved in the chromatographic separation are multi-interaction, including hydrophobic, π-π, hydrogen-bonding, dipole-dipole and ion-dipole interactions...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738623/analysis-of-illegal-peptide-drugs-via-hilic-dad-ms
#17
Steven Janvier, Evelien De Sutter, Evelien Wynendaele, Bart De Spiegeleer, Celine Vanhee, Eric Deconinck
Biopharmaceuticals have established themselves as highly efficient medicines, and are still one of the fastest growing parts of the health-product industry. Unfortunately, the introduction of these promising new drugs went hand in hand with the creation of a black market for illegal and counterfeit biotechnology drugs. Particularly popular are the lyophilised peptides with a molecular weight of less than 5kDa. Most of them are meant for subcutaneous injection and are easily accessible via the internet. In recent years, different methods based on reversed phase liquid chromatography have been developed to detect and quantify these peptides...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738603/vortex-assisted-liquid-liquid-liquid-microextraction-followed-by-high-performance-liquid-chromatography-for-the-simultaneous-determination-of-fourteen-phenolic-acids-in-honey-iced-tea-and-canned-coffee-drinks
#18
Marwan Shalash, Ahmad Makahleh, Salizawati Muhamad Salhimi, Bahruddin Saad
A vortex-assisted liquid-liquid-liquid microextraction method followed by high performance liquid chromatography-diode array detection for the determination of fourteen phenolic acids (cinnamic, m-coumaric, chlorogenic, syringic, ferulic, o-coumaric, p-coumaric, vanillic, p-hydroxybenzoic, caffeic, 2, 4-dihydroxybenzoic, sinapic, gentisic and gallic acids) in honey, iced tea and canned coffee drink samples has been developed. The separation was achieved using a Poroshell 120-EC-C18 column under a gradient elution at a flow rate of 0...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738596/chromatographic-separation-of-racemic-praziquantel-and-its-residual-determination-in-perch-by-lc-ms-ms
#19
Limin He, Fuming Gao, Erfen Li, Jauh Tzuoh Lee, Liangqiao Bian, Daniel W Armstrong
An enantioselective depletion study of praziquantel (PZQ) in perch muscle was done using a simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Two cyclic polypeptides and two cyclic saccharide chromatographic columns were evaluated. The new hydroxypropyl β-cyclodextrin (HP-RSP) superficially porous particle (SPP) column produced the optimum separation and was selected for the study. Deuterium labeled PZQ-d11 was used as the internal standard. The method was linear over concentration ranges of 5...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738591/procedures-for-precise-measurements-of-135-cs-137-cs-atom-ratios-in-environmental-samples-at-extreme-dynamic-ranges-and-ultra-trace-levels-by-thermal-ionization-mass-spectrometry
#20
James A Dunne, David A Richards, Hsin-Wei Chen
Determination of (135)Cs/(137)Cs atom ratios has the potential to be a powerful tool for nuclear forensics and monitoring environmental processes. We present optimized chemical separation techniques and thermal ionization mass spectrometry (TIMS) protocols to obtain precise (135)Cs/(137)Cs atom ratios for a range of environmental sample types. We use a combination of double AMP-PAN separation and Sr-spec resin column purification to yield excellent separation from the alkali metals (Rb separation factor > 600), which normally suppress ionization of Cs...
November 1, 2017: Talanta
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