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https://www.readbyqxmd.com/read/28341115/fewer-out-of-sequence-vaccinations-and-reduction-of-child-mortality-in-northern-ghana
#1
Paul Welaga, Abraham Oduro, Cornelius Debpuur, Peter Aaby, Henrik Ravn, Andreas Andersen, Fred Binka, Abraham Hodgson
BACKGROUND: Studies suggest that diphtheria-tetanus-pertussis (DTP) vaccine administered simultaneously with measles vaccine (MV) or DTP administered after MV are associated with higher child mortality than having MV-after-DTP3 as most recent vaccination. We tested this in Northern Ghana where the prevalence of such out-of-sequence vaccinations has declined. METHODS: Using annual cohort data of children aged 12-23months from 1996 to 2012 and Cox proportional hazards models, we assessed survival in relation to the most recent vaccination status within the next 12months and until five years of age...
March 21, 2017: Vaccine
https://www.readbyqxmd.com/read/28339574/arm-paralysis-after-routine-childhood-vaccinations-application-of-advanced-molecular-methods-to-the-causality-assessment-of-an-adverse-event-after-immunization
#2
Jana Shaw, Neal A Halsey, Adriana Weinberg, D Scott Schmid, Kirsten St George, William C Weldon, Michael Jordan, Patrick W Bryant, Philip S LaRussa, Deborah Y Bradshaw, Theresa Harrington, Anne Gershon
Post-licensure surveillance for adverse events following immunizations (AEFI) can identify rare complications of vaccinations and rigorous vaccine adverse event causality assessments can help to identify possible causal relationships. We report the development of arm paralysis after varicella vaccination in a 1-year-old child. Paralysis was initially presumed to be due to vOka because of the temporal relationship between vaccination and onset of arm weakness; however, molecular studies identified wild-type varicella zoster virus VZV (WT-VZV) in the CSF, leading the authors to conclude that WT-VZV was the probable cause...
January 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28339568/varicella-in-a-previously-immune-patient-with-leukemia
#3
Michelle Sewnarine, Sujatha Rajan, Arlene Redner, Lorry G Rubin
Infection with varicella-zoster virus (VZV) in oncology patients can result in severe disease with an increased risk of morbidity and mortality [1, 2]. Among patients on cancer chemotherapy, only nonimmune persons are considered to be susceptible to varicella [1]. We present a case of varicella in a child with leukemia that occurred despite immunity as defined by 2 doses of varicella vaccine and documentation of positive VZV immunoglobulin G titer before initiation of chemotherapy.
January 19, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28337738/does-birth-under-registration-reduce-childhood-immunization-evidence-from-the-dominican-republic
#4
Steve Brito, Ana Corbacho, Rene Osorio
The consequences of lacking birth certificates remain largely unexplored in the economic literature. We intend to fill this knowledge gap studying the effect of lacking birth certificates on immunization of children in the Dominican Republic. This is an interesting country because a significant number of children of Haitian descent face the consequences of lacking proper documentation. We use the distance to the civil registry office and the mother's document of identification as instrumental variables of the child's birth certificate...
December 2017: Health Economics Review
https://www.readbyqxmd.com/read/28328809/infectious-diseases-prevalence-vaccination-coverage-and-diagnostic-challenges-in-a-population-of-internationally-adopted-children-referred-to-a-tertiary-care-children-s-hospital-from-2009-to-2015
#5
Sara Sollai, Francesca Ghetti, Leila Bianchi, Maurizio de Martino, Luisa Galli, Elena Chiappini
Infectious diseases are common in internationally adopted children (IAC).With the objective to evaluate infectious diseases prevalence in a large cohort of IAC and to explore possible risk factors for tuberculosis (TB) and parasitic infections, clinical and laboratory data at first screening visit of all IAC (<18 years) consecutively referred to our Center in 2009 to 2015 were collected and analyzed.In total, 1612 children (median age: 5.40 years; interquartile range: 3.00-7.90) were enrolled, 123/1612 (7...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28326845/the-use-of-biologics-in-pregnant-patients-with-rheumatic-disease
#6
Monika Østensen
An increasing number of female patients with autoimmune diseases are treated with biologic drugs. Concerns in regard to safety of biologics during pregnancy arise in patients who have not completed their families. Areas covered: A review of the literature dealing with child outcomes of pregnancies exposed to biologics shows that TNF inhibitors (TNFi) are the best studied in regard to human pregnancy. In studies comparing exposed pregnancies to disease-matched controls no increased risk of spontaneous abortion, low birth weight, prematurity or congenital malformations has been observed...
March 22, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28322704/transmission-of-hepatitis-a-virus-through-combined-liver-small-intestine-pancreas-transplantation
#7
Monique A Foster, Lauren M Weil, Sherry Jin, Thomas Johnson, Tonya R Hayden-Mixson, Yury Khudyakov, Pallavi D Annambhotla, Sridhar V Basavaraju, Saleem Kamili, Jana M Ritter, Noele Nelson, George Mazariegos, Michael Green, Ryan W Himes, David T Kuhar, Matthew J Kuehnert, Jeffrey A Miller, Rachel Wiseman, Anne C Moorman
Although transmission of hepatitis A virus (HAV) through blood transfusion has been documented, transmission through organ transplantation has not been reported. In August 2015, state health officials in Texas, USA, were notified of 2 home health nurses with HAV infection whose only common exposure was a child who had undergone multi-visceral organ transplantation 9 months earlier. Specimens from the nurses, organ donor, and all organ recipients were tested and medical records reviewed to determine a possible infection source...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28321649/adolescent-participation-in-hpv-vaccine-clinical-trials-are-parents-willing
#8
Jennifer Cunningham Erves, Tilicia L Mayo-Gamble, Pamela C Hull, Lauren Duke, Stephania T Miller
Approximately one-quarter of human papillomavirus (HPV) infections are acquired by adolescents, with a higher burden among racial/ethnic minorities. However, racial/ethnic minorities have been underrepresented in previous HPV vaccine trials. Ongoing and future HPV vaccine optimization trials would benefit from racially- and ethnically-diverse sample of adolescent trial participants. This study examined factors influencing parental willingness to consent to their adolescents' participation in HPV vaccine clinical trials and tested for possible racial differences...
March 21, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28320387/case-report-atypical-hemolytic-uremic-syndrome-triggered-by-influenza-b
#9
Robin Kobbe, Raphael Schild, Martin Christner, Jun Oh, Sebastian Loos, Markus J Kemper
BACKGROUND: Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS. CASE PRESENTATION: A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission...
March 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28319453/prenatal-vaccination-education-intervention-improves-both-the-mothers-knowledge-and-children-s-vaccination-coverage-evidence-from-randomized-controlled-trial-from-eastern-china
#10
Yu Hu, Yaping Chen, Ying Wang, Quanwei Song, Qian Li
OBJECTIVES: To verify the effectiveness of prenatal vaccination education intervention on improving mother's vaccination knowledge and child's vaccination status in Zhejiang province, eastern China. METHODS: Pregnant women with ≥ 12 gestational weeks were recruited and randomly assigned into the intervention group and the control group. The intervention group were given a vaccination education session while the control group were not. Two round surveys were performed before and 3 months after the intervention...
February 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28318766/bacille-calmette-gu%C3%A3-rin-bcg-vaccination-at-birth-and-antibody-responses-to-childhood-vaccines-a-randomised-clinical-trial
#11
Thomas Nørrelykke Nissen, Nina Marie Birk, Gaby Smits, Dorthe Lisbeth Jeppesen, Lone Graff Stensballe, Mihai G Netea, Fiona van der Klis, Christine Stabell Benn, Ole Pryds
INTRODUCTION: BCG vaccination has been associated with beneficial non-specific effects on child health. Some immunological studies have reported heterologous effects of vaccines on antibody responses to heterologous vaccines. Within a randomised clinical trial of Bacille Calmette-Guérin (BCG) vaccination at birth, The Danish Calmette Study, we investigated the effect of BCG at birth on the antibody response to the three routine vaccines against DiTeKiPol/Act-Hib and Prevenar 13 in a subgroup of participants...
March 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28317146/immunization-of-looked-after-children-and-young-people-a-review-of-the-literature
#12
REVIEW
S Walton, H Bedford
BACKGROUND: Numbers of looked-after children and young people (LACYP) in the UK have risen over the last seven years. Looked-after children and young people should receive regular health assessments, including establishing immunization status and, if needed, developing a health plan to achieve full immunization. The Department for Education publish data on immunizations among LACYP to monitor both how well they are immunized and service performance. METHODS: A literature review was conducted using four databases (PubMed, Embase, Scopus and Web of Science) on immunization status of LACYP, factors affecting uptake and challenges to immunization, and interventions to improve immunization rates...
March 19, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28304316/perspectives-and-attitudes-of-pediatricians-concerning-post-discharge-care-practice-of-premature-infants
#13
A Gad, E Parkinson, N Khawar, A Elmeki, P Narula, D Hoang
OBJECTIVE: Survival rates of premature infants are at a historical high and increasingly more pediatricians are caring for former premature infants. The goal of this study was to describe the perspectives and attitudes of pediatricians, as well as, the challenges of rendering post-neonatal intensive care unit (NICU) discharge care for premature infants. METHODS: An anonymous 22-question web-based survey was emailed to pediatricians who are current members of the American Academy of Pediatrics (AAP) and practicing in Kings County, New York...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28301539/identifying-inequities-in-maternal-and-child-health-through-risk-stratification-to-inform-health-systems-strengthening-in-northern-togo
#14
Katharine J McCarthy, Sandra Braganza, Kevin Fiori, Christophe Gbeleou, Vivien Kpakpo, Andrew Lopez, Jennifer Schechter, Alicia Singham Goodwin, Heidi E Jones
OBJECTIVE: In Togo, substantial progress in maternal and child health is needed to reach global development goals. To better inform clinic and community-based health services, this study identifies factors associated with maternal and child health care utilization in the Kara region of Northern Togo. METHODS: We conducted a population-representative household survey of four health clinic catchment areas of 1,075 women of reproductive age in 2015. Multivariable logistic regression was used to model individual and structural factors associated with utilization of four maternal and child health services...
2017: PloS One
https://www.readbyqxmd.com/read/28300971/culture-versus-the-law-in-the-decision-not-to-vaccinate-children-meanings-assigned-by-middle-class-couples-in-s%C3%A3-o-paulo-brazil
#15
Carolina Luisa Alves Barbieri, Márcia Thereza Couto, Fernando Mussa Abujamra Aith
This study aimed to learn how middle-class parents in the city of São Paulo, Brazil, interpreted the country's prevailing vaccination requirements, based on their experiences with vaccinating, selectively vaccinating, or not vaccinating their children. A qualitative approach was used with in-depth interviews. The analytical process was guided by content analysis and the theoretical framework of the anthropology of the law and morality. For parents that vaccinated, Brazil's culture of immunization outweighed the feeling of compliance with the law; for selective parents, selection of vaccines was not perceived as deviating from the law...
March 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28300047/knowledge-attitude-and-experience-of-cervical-cancer-and-screening-among-sub-saharan-african-female-students-in-a-uk-university
#16
Faith Sopuruchukwu Ogbonna
BACKGROUND: Cervical cancer is one of the major diseases that affect women of child bearing age. Its main cause is the human papilloma virus; although, other associated factors have been evidenced to increase its risk. Pap-smear screening and vaccination which has been shown to be successful in reducing the incidence and prevalence of the disease in developed countries, has been neglected in developing countries due to lack of knowledge, misconceptions, and cultural beliefs. MATERIALS AND METHODS: A cross-sectional study involving only female Sub-Saharan Africa (SSA) students in a UK university setting...
January 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28299785/should-obese-women-s-access-to-assisted-fertility-treatment-be-limited-a-scientific-and-ethical-analysis
#17
Kelton Tremellen, Dominic Wilkinson, Julian Savulescu
Obesity is associated with a reduction in fertility treatment success and increased risks to mother and child. Therefore guidelines of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) suggest that a body mass index exceeding 35 kg/m(2) should be an absolute contraindication to assisted fertility treatment such as in vitro fertilisation IVF. In this paper we challenge the ethical and scientific basis for such a ban. Livebirth rates for severely obese women are reduced by up to 30%, but this result is still far better than that observed for many older women who are allowed access to IVF...
March 16, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28299162/sero-prevalence-of-hepatitis-b-surface-antigen-amongst-pregnant-women-attending-an-antenatal-clinic-volta-region-ghana
#18
Arnold Luuse, Sylvester Dassah, Sylvester Lokpo, Louise Ameke, Mark Noagbe, Peter Adatara, Oheneba Hagan, Fred Binka
Hepatitis B virus (HBV) infection remains a global challenge, although there is currently a safe and effective vaccine available. HBV prevalence in Ghana is not well documented, but vary regionally from 4.8% to 12.3% in the general population, 10.8% to 12.7% in blood donors and about 10.6% in pregnant women. This puts Ghana among the high endemic countries in Africa. The study objective was to determine the sero-prevalence of HBs antigen (Ag) and HBeAg among pregnant women in the Ho municipality. Two hundred and eigh participants (pregnant women), attending Ho Municipal antenatal clinic were enrolled into the study...
December 31, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28298206/burden-and-spectrum-of-bacterial-infections-among-sickle-cell-disease-children-living-in-cameroon
#19
Anastasie Nicole Alima Yanda, Jobert Richie N Nansseu, Hubert Désiré Mbassi Awa, Sandra A Tatah, Judith Seungue, Charlotte Eposse, Paul Olivier N Koki
BACKGROUND: Although sickle cell disease (SCD) children are highly susceptible to bacterial infections (BIs), there is a dreadful lack of data related to the burden and spectrum of BIs in sub-Saharan Africa (SSA), the highest affected region with SCD. This study aimed to determine the burden and spectrum of BIs among SCD children hospitalized in a pediatric reference hospital in Cameroon, a SSA country. METHODS: We conducted a retrospective analysis of records of children hospitalized from November 2012 to August 2015 in the SCD unit of the Mother and Child Centre of the Chantal Biya Foundation, Cameroon...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28293422/regional-disparities-in-immunization-services-in-ghana-through-a-bottleneck-analysis-approach-implications-for-sustaining-national-gains-in-immunization
#20
A E Yawson, G Bonsu, L K Senaya, A O Yawson, J B Eleeza, J K Awoonor-Williams, H K Banskota, E E A Agongo
BACKGROUND: Immunization is considered one of the most cost effective public health interventions for reducing child morbidity, mortality and disability. The aim of this work is to describe the application of the Bottleneck analysis (BNA) process to assess gaps in immunization services in Ghana and implications for sustaining the gains in Immunization coverage. METHODS: A national assessment was conducted in May 2015, through use of desk reviews, field visits and key informant interviews...
2017: Archives of Public Health, Archives Belges de Santé Publique
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