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https://www.readbyqxmd.com/read/28743129/fibroblast-growth-factor-23-predicts-mortality-and-end-stage-renal-disease-in-a-canadian-asian-population-with-chronic-kidney-disease
#1
Ishwarlal Jialal, Fernando Camacho, Bharat Nathoo, Paul Tam, Roma Pahwa, George G Wu
BACKGROUND: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Biomarkers that predict end-stage renal disease (ESRD) and/or mortality could usher in new therapeutics to halt this onslaught. While fibroblast growth factor (FGF)23 can predict both ESRD and mortality, it has not been studied in North American CKD patients of Asian ethnicity. METHOD: This is a prospective investigation about the role of FGF23 in 998 Canadian patients of Asian descent with CKD defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/m2 and followed up for 3 years...
July 26, 2017: Nephron
https://www.readbyqxmd.com/read/28743125/surfactant-protein-b-suppresses-lung-cancer-progression-by-inhibiting-secretory-phospholipase-a2-activity-and-arachidonic-acid-production
#2
Sungmin Lee, Daehoon Kim, JiHoon Kang, EunGi Kim, Wanyeon Kim, HyeSook Youn, BuHyun Youn
BACKGROUND/AIMS: Radiotherapy is applied to patients with inoperable cancer types including advanced stage non-small cell lung cancer (NSCLC) and radioresistance functions as a critical obstacle in radiotherapy. This study was aimed to investigate the mechanism of radioresistance regulated by surfactant protein B (SP-B). METHODS: To investigate the role of SP-B in radioresistance, ΔSFTPB A549 cell line was established and SP-B expression was analyzed. In response to ionizing radiation (IR), the change of SP-B expression was analyzed in A549 and NCI-H441 cell lines...
July 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28742826/macromolecular-biosynthetic-parameters-and-metabolic-profile-in-different-life-stages-of-leishmania-braziliensis-amastigotes-as-a-functionally-less-active-stage
#3
Marlene Jara, Maya Berg, Guy Caljon, Geraldine de Muylder, Bart Cuypers, Denis Castillo, Ilse Maes, María Del Carmen Orozco, Manu Vanaerschot, Jean-Claude Dujardin, Jorge Arevalo
It was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana and Leishmania (Leishmania) major models might explain numerous clinical and sub-clinical features of Leishmania (Viannia) braziliensis infections, like reactivation of the disease, non-response to chemotherapy or asymptomatic infections. We compared here in vitro the proliferative capability of L...
2017: PloS One
https://www.readbyqxmd.com/read/28742823/genome-wide-identification-and-analysis-of-the-mads-box-gene-family-in-bread-wheat-triticum-aestivum-l
#4
Jian Ma, Yujie Yang, Wei Luo, Congcong Yang, Puyang Ding, Yaxi Liu, Linyi Qiao, Zhijian Chang, Hongwei Geng, Penghao Wang, Qiantao Jiang, Jirui Wang, Guoyue Chen, Yuming Wei, Youliang Zheng, Xiujin Lan
The MADS-box genes encode transcription factors with key roles in plant growth and development. A comprehensive analysis of the MADS-box gene family in bread wheat (Triticum aestivum) has not yet been conducted, and our understanding of their roles in stress is rather limited. Here, we report the identification and characterization of the MADS-box gene family in wheat. A total of 180 MADS-box genes classified as 32 Mα, 5 Mγ, 5 Mδ, and 138 MIKC types were identified. Evolutionary analysis of the orthologs among T...
2017: PloS One
https://www.readbyqxmd.com/read/28742813/taste-preference-changes-throughout-different-life-stages-in-male-rats
#5
Chizuko Inui-Yamamoto, Takashi Yamamoto, Katsura Ueda, Michiko Nakatsuka, Shunji Kumabe, Tadashi Inui, Yasutomo Iwai
Taste preference, a key component of food choice, changes with aging. However, it remains unclear how this occurs. To determine differences in taste preference between rats in different life stages, we examined the consumption of taste solutions and water using a two-bottle test. Male Sprague-Dawley rats of different ages were used: juvenile (3-6 weeks), young adult (8-11 weeks), adult (17-20 weeks), middle-aged (34-37 weeks), and old-aged (69-72 weeks). The intakes of the high and low concentration solutions presented simultaneously were measured...
2017: PloS One
https://www.readbyqxmd.com/read/28742406/the-efficacy-of-low-dose-tadalafil-in-patients-undergoing-hemodialysis-with-end-stage-renal-disease
#6
Mustafa Suat Bolat, İsmail Özer, Onder Cinar, Ekrem Akdeniz, Ramazan Aşcı
BACKGROUND: Erectile dysfunction (ED) is a disorder that is frequently observed in people with chronic kidney disease who undergo hemodialysis (HD). In the context of evidence-based medicine, we aimed to investigate the effect of low-dose tadalafil on sexual function in patients undergoing HD. METHODS: The medical records of 30 males (aged 29-65 years) with end-stage renal disease (ESRD) on a HD program, and who had received 5 mg tadalafil twice weekly, were retrospectively evaluated...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28742385/sequential-therapy-of-breast-cancer-cell-lines-with-vitamin-c-and-quercetin-improves-the-efficacy-of-chemotherapeutic-drugs
#7
Fatemeh Ramezani, Nasser Samadi, Zohreh Mostafavi-Pour
OBJECTIVE: Prevention by antioxidant agents including vitamin C (VC) and quercetin (QU), which are nontoxic, cost effective, and physiologically bioavailable, is a promising approach in breast cancer handling. The aim of this work is to investigate the influence of VC+QU on cytotoxicity profile of doxorubicin (DOX) plus paclitaxel (PAC) in breast cancer cells. METHODS: The effect of each drug on its own or in combination was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
July 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28742145/survival-analysis-of-conservative-vs-dialysis-treatment-of-elderly-patients-with-ckd-stage-5
#8
Roman Reindl-Schwaighofer, Alexander Kainz, Michael Kammer, Alexandra Dumfarth, Rainer Oberbauer
Elderly patients represent a growing population among people suffering from ESRD. So far only limited data on actual survival benefits of elderly adults initiating dialysis have been published. Besides the high burden of preexisting comorbidities, dialysis treatment itself may be associated with a further deterioration in functional status in this population. We retrospectively analyzed the Austrian Dialysis and Transplant Registry and identified 8,622 patients who started maintenance hemodialysis after the age of 65 years between 2002 and 2009...
2017: PloS One
https://www.readbyqxmd.com/read/28742088/genome-wide-identification-of-hami-melon-mirnas-with-putative-roles-during-fruit-development
#9
Hong Zhang, Lan Yin, Huaisong Wang, Guangzhi Wang, Xinli Ma, Meihua Li, Haibo Wu, Qiushi Fu, Yi Zhang, Hongping Yi
MicroRNAs represent a family of small endogenous, non-coding RNAs that play critical regulatory roles in plant growth, development, and environmental stress responses. Hami melon is famous for its attractive flavor and excellent nutritional value, however, the mechanisms underlying the fruit development and ripening remains largely unknown. Here, we performed small RNA sequencing to investigate the roles of miRNAs during Hami melon fruit development. Two batches of flesh samples were collected at four fruit development stages...
2017: PloS One
https://www.readbyqxmd.com/read/28741996/transcriptome-changes-associated-with-tomato-spotted-wilt-virus-infection-in-various-life-stages-of-its-thrips-vector-frankliniella-fusca-hinds
#10
Anita Shrestha, Donald E Champagne, Albert K Culbreath, Dorith Rotenberg, Anna E Whitfield, Rajagopalbabu Srinivasan
Persistent propagative viruses maintain intricate interactions with their arthropod vectors. In this study, we investigated the transcriptome-level responses associated with a persistent propagative phytovirus infection in various life stages of its vector using an Illumina HiSeq sequencing platform. The pathosystem components included a Tospovirus, Tomato spotted wilt virus (TSWV), its insect vector, Frankliniella fusca (Hinds), and a plant host, Arachis hypogaea (L.). We assembled (de novo) reads from three developmental stage groups of virus-exposed and non-virus-exposed F...
July 26, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28741985/the-influence-of-fasudil-on-renal-proximal-tubular-cell-epithelial-mesenchymal-transition-induced-by-parathormone
#11
Ziqing Gao, Weiping Zhu, Hua Zhang, Zhonghe Li, Tongxia Cui
BACKGROUND: Renal fibrosis is a common pathway through which a variety of chronic kidney diseases progress to end-stage renal disease. Epithelial-mesenchymal transition (EMT) of renal proximal tubular cells is one of the most important factors in renal fibrosis. This study investigates if fasudil could influence EMT of renal proximal tubular cells. METHODS: HK-2 cells in passage 3-4 were used for all experiments. The cells were divided into five groups and treated with different concentrations of PTH and then observe cellular morphological changes at 0, 24 and 48 h using an inverted microscope and investigate the expression of the epithelial cell marker E-cadherin and the renal fibroblast marker α-smooth muscle actin (α-SMA)...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28741900/the-avidity-of-tumor-specific-t-cells-amplified-by-a-pdc-based-assay-can-predict-the-clinical-evolution-of-melanoma-patients
#12
Julie Charles, Laurence Chaperot, Bruno Revol, Marine Baudin, Stephane Mouret, Agnes Hamon, Marie-Therese Leccia, Joel Plumas, Caroline Aspord
The advent of immune-checkpoint blockers and targeted therapies has changed the outcome of melanoma. However, many patients experience relapses, emphasizing the need for predictive and prognostic biomarkers. We developed a strategy based on plasmacytoid dendritic cells (pDCs) loaded with melanoma-tumor antigens that allows eliciting highly efficient antitumor T-cell responses. We used it to investigate antitumor T-cell functionality in peripheral blood mononuclear cells and tumor-infiltrating lymphocytes from melanoma patients...
July 25, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28741732/lung-cancer-short-term-reproducibility-of-intravoxel-incoherent-motion-parameters-and-apparent-diffusion-coefficient-at-3t
#13
Jianqin Jiang, Jianbin Yin, Lei Cui, Xiaowen Gu, Rongfang Cai, Shenchu Gong, Yiming Xu, Hang Ma, Jian Mao
PURPOSE: To prospectively evaluate the short-term reproducibility of intravoxel incoherent motion (IVIM) parameters and apparent diffusion coefficient (ADC) in lung cancer patients. MATERIALS AND METHODS: In all, 50 patients (50 lesions) underwent free-breathing diffusion-weighted imaging (DWI) (b = 0, 300, 800 s/mm(2) ) and IVIM (10 b-values, 0-1000 s/mm(2) ) scans twice (0.5-1-hour interval) at 3T. Regions of interests (ROIs) were drawn on ADC maps and IVIM images to derive the mean ADC value and IVIM parameters D, D*, and f...
July 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28741696/age-dependent-regulation-of-erf-vii-transcription-factor-activity-in-arabidopsis-thaliana
#14
Beatrice Giuntoli, Vinay Shukla, Federica Maggiorelli, Federico M Giorgi, Lara Lombardi, Pierdomenico Perata, Francesco Licausi
The group VII Ethylene Responsive Factors (ERF-VII) RAP2.2 and RAP2.12 have been mainly characterized with regards to their contribution as activators of fermentation in plants. However, transcriptional changes measured in conditions that stabilise these transcription factors exceed the mere activation of this biochemical pathway, implying additional roles performed by the ERF-VIIs in other processes. We evaluated gene expression in transgenic Arabidopsis lines expressing a stabilised form of RAP2.12, or hampered in ERF-VII activity, and identified genes affected by this transcriptional regulator and its homologs, including some involved in oxidative stress response, which are not universally induced under anaerobic conditions...
July 25, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28741443/stabilizing-family-life-after-gastric-bypass-surgery
#15
Ami Bylund, Eva Benzein, Anna Sandgren
Weight-loss surgery requires lifelong lifestyle modifications for the maintenance of weight loss and health effects, and can affect both the individual and family. Earlier research indicates that the quality of social relationships has positive and negative influences on wellbeing and health. There is little research on family-life after a member has undergone gastric bypass (GBP) against obesity. Thus, this study aimed to develop a classic grounded theory about families with a member treated with GBP against obesity...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28741416/american-joint-committee-on-cancer-eighth-edition-changes-in-staging-criteria-implications-for-data-collection
#16
Anirudh Saraswathula, Michelle Chen, Serban Negoita, Vasu Divi
The American Joint Committee on Cancer, in the eighth edition of its cancer staging manual, makes a number of changes to improve survival predictions in human malignancy. In this commentary, we examine the national collection of data for head and neck cancer. We outline and review the major changes made in head and neck cancer staging, identify the key data elements that will need to be collected with the new edition's criteria, and discuss the institutional adjustments currently being made to data collection under the new guidelines to improve the quality of data in our national cancer databases...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28741200/short-and-long-term-outcomes-in-malnourished-patients-after-laparoscopic-or-open-radical-gastrectomy
#17
Hua-Long Zheng, Jun Lu, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
OBJECTIVE: The aim of this study was to compare the short- and long-term outcomes of malnourished gastric cancer patients who underwent laparoscopic or open radical gastrectomy. BACKGROUND: Preoperative malnutrition is an independent risk factor for postoperative mortality and morbidity in major gastrointestinal surgery. However, whether laparoscopic surgery can improve the short- and long-term outcomes of malnourished gastric cancer patients has not been determined...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28741080/transcriptomic-analyses-reveal-clathrin-mediated-endocytosis-involved-in-symbiotic-seed-germination-of-gastrodia-elata
#18
Xu Zeng, Yuanyuan Li, Hong Ling, Sisi Liu, Mengmeng Liu, Juan Chen, Shunxing Guo
BACKGROUND: Gastrodia elata is a well-known medicinal orchid. In nature, the germination rate of G. elata is extremely poor, because there is no endosperm within the mature seed. It is crucial for G. elata to obtain nutrition from mycorrhizal fungi (Mycena) at the early-stage of germination. After germination, the seed gives rise to a protocorm. However, there are no "omic" studies on understanding the interaction between Gastrodia and Mycena. Here, we used transcriptomic approaches to explore changes in seed germination of G...
December 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28740675/feasibility-of-four-arm-robotic-lobectomy-as-solo-surgery-in-patients-with-clinical-stage-i-lung-cancer
#19
Seong Yong Park, Jee Won Suh, Kyoung Sik Narm, Chang Young Lee, Jin Gu Lee, Hyo Chae Paik, Kyoung Young Chung, Dae Joon Kim
BACKGROUND: This study was performed to investigate the feasibility of four-arm robotic lobectomy (FARL) as a solo surgical technique in patients with non-small cell lung cancer (NSCLC). Early outcome and long-term survival of FARL were compared with those of video-assisted thoracoscopic lobectomy (VATL). METHODS: Prospective enrollment of patients with clinical stage I NSCLC undergoing FARL or VATL (20 patients in each group) was planned. Interim analysis for early postoperative outcome was performed after the initial 10 cases in each group...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740584/cardiovascular-disease-in-acromegaly
#20
Morali D Sharma, Anh V Nguyen, Spandana Brown, Richard J Robbins
In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications...
April 2017: Methodist DeBakey Cardiovascular Journal
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