keyword
MENU ▼
Read by QxMD icon Read
search

mixed malaria

keyword
https://www.readbyqxmd.com/read/28095916/insecticide-treated-net-effectiveness-at-preventing-plasmodium-falciparum-infection-varies-by-age-and-season
#1
Andrea G Buchwald, Jenna E Coalson, Lauren M Cohee, Jenny A Walldorf, Nelson Chimbiya, Andy Bauleni, Kondwani Nkanaunena, Andrew Ngwira, John D Sorkin, Don P Mathanga, Terrie E Taylor, Miriam K Laufer
BACKGROUND: After increasing coverage of malaria interventions, malaria prevalence remains high in Malawi. Previous studies focus on the impact of malaria interventions among children under 5 years old. However, in Malawi, the prevalence of infection is highest in school-aged children (SAC), ages 5 to 15 years. This study examined the interaction between age group and insecticide-treated net (ITN) use for preventing individual and community-level infection in Malawi. METHODS: Six cross-sectional surveys were conducted in the rainy and dry seasons in southern Malawi from 2012 to 2014...
January 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28077587/malaria-parasitemia-and-parasite-density-in-antiretroviral-treated-hiv-infected-adults-following-discontinuation-of-cotrimoxazole-prophylaxis
#2
Ronald K Ottichilo, Christina S Polyak, Bernard Guyah, Benson Singa, Josphat Nyataya, Krista Yuhas, Grace John-Stewart, John N Waitumbi
BACKGROUND:  Cotrimoxazole (CTX) discontinuation increases malaria incidence in human immunodeficiency virus (HIV)-infected individuals. Rates, quantity, and timing of parasitemia rebound following CTX remain undefined. METHODS:  Serial specimens from a trial of HIV-infected individuals receiving antiretroviral treatment (ART) randomized to continue (the CTX arm) or discontinue (the STOP-CTX arm) were examined for malaria parasites by quantitative reverse transcription polymerase chain reaction (PCR)...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28072872/population-pharmacokinetic-properties-of-piperaquine-in-falciparum-malaria-an-individual-participant-data-meta-analysis
#3
Richard M Hoglund, Lesley Workman, Michael D Edstein, Nguyen Xuan Thanh, Nguyen Ngoc Quang, Issaka Zongo, Jean Bosco Ouedraogo, Steffen Borrmann, Leah Mwai, Christian Nsanzabana, Ric N Price, Prabin Dahal, Nancy C Sambol, Sunil Parikh, Francois Nosten, Elizabeth A Ashley, Aung Pyae Phyo, Khin Maung Lwin, Rose McGready, Nicholas P J Day, Philippe J Guerin, Nicholas J White, Karen I Barnes, Joel Tarning
BACKGROUND: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated Plasmodium falciparum malaria, but ACT resistance is spreading across Southeast Asia. Dihydroartemisinin-piperaquine is one of the five ACTs currently recommended by the World Health Organization. Previous studies suggest that young children (<5 y) with malaria are under-dosed. This study utilised a population-based pharmacokinetic approach to optimise the antimalarial treatment regimen for piperaquine...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28031267/assessment-of-the-plasmodium-falciparum-pre-erythrocytic-antigen-uis3-as-a-potential-candidate-for-a-malaria-vaccine
#4
Rhea J Longley, Benedict R Halbroth, Ahmed M Salman, Katie J Ewer, Susanne H Hodgson, Chris J Janse, Shahid M Khan, Adrian V S Hill, Alexandra J Spencer
Efforts are currently underway to improve the efficacy of sub-unit malaria vaccines through assessment of new adjuvants, vaccination platforms and antigens. In this study, we further assess the antigen P. falciparum (Pf) upregulated in infective sporozoites 3 (PfUIS3) as a vaccine candidate. PfUIS3 was expressed in the viral vectors chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) and used to immunize mice in a prime-boost regimen. We previously demonstrated that this regimen could provide partial protection against challenge with chimeric P...
December 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27994102/intermittent-preventive-treatment-with-sulfadoxine-pyrimethamine-more-than-just-an-antimalarial
#5
EDITORIAL
Julie Gutman, Laurence Slutsker
Malaria in pregnancy is associated with increased risk for both maternal and neonatal adverse outcomes, notably low birthweight and neonatal mortality.(1) Since 2004, following studies that showed that intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) reduced the risk of these adverse events,(2) the World Health Organization (WHO) recommended IPTp-SP for all areas in Africa with moderate-to-high malaria transmission.(3) IPTp-SP is associated with significant reductions in low birthweight, with a protective efficacy of approximately 26% in an analysis of national survey data from 32 countries...
December 19, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27989273/beyond-test-and-treat-malaria-diagnosis-for-improved-pediatric-fever-management-in-sub-saharan-africa
#6
Emily White Johansson
BACKGROUND: Malaria rapid diagnostic tests (RDTs) have great potential to improve quality care and rational drug use in malaria-endemic settings although studies have shown common RDT non-compliance. Yet, evidence has largely been derived from limited hospital settings in few countries. This article reviews a PhD thesis that analyzed national surveys from multiple sub-Saharan African countries to generate large-scale evidence of malaria diagnosis practices and its determinants across different contexts...
2016: Global Health Action
https://www.readbyqxmd.com/read/27982119/declining-prevalence-of-disease-vectors-under-climate-change
#7
Luis E Escobar, Daniel Romero-Alvarez, Renato Leon, Manuel A Lepe-Lopez, Meggan E Craft, Mercy J Borbor-Cordova, Jens-Christian Svenning
More than half of the world population is at risk of vector-borne diseases including dengue fever, chikungunya, zika, yellow fever, leishmaniasis, chagas disease, and malaria, with highest incidences in tropical regions. In Ecuador, vector-borne diseases are present from coastal and Amazonian regions to the Andes Mountains; however, a detailed characterization of the distribution of their vectors has never been carried out. We estimate the distribution of 14 vectors of the above vector-borne diseases under present-day and future climates...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27966198/contribution-of-real-time-pcr-to-plasmodium-species-identification-and-to-clinical-decisions-a-nationwide-study-in-a-non-endemic-setting
#8
T Grossman, E Schwartz, J Vainer, V Agmon, Y Glazer, D Goldmann, E Marva
Treatment choice for patients with malaria in Israeli hospitals is based on microscopy and rapid diagnostic tests (RDTs). Here, we demonstrate the cumulative value of real-time polymerase chain reaction (PCR) in optimizing the treatment of malaria. Between January 2009 and December 2015, 451 samples from 357 patients were tested in our laboratory using a real-time PCR assay. Hospital laboratory results (without real-time PCR) were compared to those obtained in our laboratory. A total of 307 patients had a malaria-positive laboratory finding in the hospital...
December 13, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27965266/indoor-residual-spraying-delivery-models-to-prevent-malaria-comparison-of-community-and-district-based-approaches-in-ethiopia
#9
Benjamin Johns, Yemane Yeebiyo Yihdego, Lena Kolyada, Dereje Dengela, Sheleme Chibsa, Gunawardena Dissanayake, Kristen George, Hiwot Solomon Taffese, Bradford Lucas
BACKGROUND: Indoor residual spraying (IRS) for malaria prevention has traditionally been implemented in Ethiopia by the district health office with technical and operational inputs from regional, zonal, and central health offices. The United States President's Malaria Initiative (PMI) in collaboration with the Government of Ethiopia tested the effectiveness and efficiency of integrating IRS into the government-funded community-based rural health services program. METHODS: Between 2012 and 2014, PMI conducted a mixed-methods study in 11 districts of Oromia region to compare district-based IRS (DB IRS) and community-based IRS (CB IRS) models...
December 23, 2016: Global Health, Science and Practice
https://www.readbyqxmd.com/read/27941968/reactive-case-detection-for-plasmodium-vivax-malaria-elimination-in-rural-amazonia
#10
Pablo S Fontoura, Bruna F Finco, Nathália F Lima, Jaques F de Carvalho, Joseph M Vinetz, Márcia C Castro, Marcelo U Ferreira
BACKGROUND: Malaria burden in Brazil has reached its lowest levels in 35 years and Plasmodium vivax now accounts for 84% of cases countrywide. Targeting residual malaria transmission entrenched in the Amazon is the next major challenge for ongoing elimination efforts. Better strategies are urgently needed to address the vast reservoir of asymptomatic P. vivax carriers in this and other areas approaching malaria elimination. METHODS: We evaluated a reactive case detection (RCD) strategy tailored for P...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27933559/-contribution-of-nested-pcr-in-the-diagnosis-of-imported-malaria-in-southern-algeria
#11
L Bouiba, B Gassen, M Gasmi, D Hammadi, Z Harrat
The nested PCR was used to estimate its inputs in malaria diagnosis and in the performance of the microscope operators involved in the surveillance of malaria in remote areas of South Algeria. For the period 2010 to 2015, 112 patients (93 febrile and 19 asymptomatic) coming from sub-Saharan Africa were tested for malaria in the hospital of Tamanrasset. One part of the blood taken from fingertip was used for blood smears and the second part was absorbed in filter paper for molecular diagnosis. Overall, the infection was detected by nested PCR in 63 samples versus 53 by direct examination...
December 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27932882/sustained-release-liquisolid-compact-tablets-containing-artemether-lumefantrine-as-alternate-day-regimen-for-malaria-treatment-to-improve-patient-compliance
#12
Petra Obioma Nnamani, Agatha Adaora Ugwu, Emmanuel Chinedu Ibezim, Franklin Chimaobi Kenechukwu, Paul Achile Akpa, John-Dike Nwabueze Ogbonna, Nicholas Chinedu Obitte, Amelia Ngozi Odo, Maike Windbergs, Claus-Michael Lehr, Anthony Amaechi Attama
The present study aimed to develop low-dose liquisolid tablets of two antimalarial drugs artemether-lumefantrine (AL) from a nanostructured lipid carrier (NLC) of lumefantrine (LUM) and estimate the potential of AL as an oral delivery system in malariogenic Wistar mice. LUM-NLCs were prepared by hot homogenization using Precirol(®) ATO 5/Transcutol(®) HP and tallow fat/Transcutol(®) HP optimized systems containing 3:1 ratios of the lipids, respectively, as the matrices. LUM-NLC characteristics, including morphology, particle size, zeta potential, encapsulation efficiency, yield, pH-dependent stability, and interaction studies, were investigated...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27932615/anopheles-salivary-biomarker-to-assess-malaria-transmission-risk-along-the-thailand-myanmar-border
#13
Phubeth Ya-Umphan, Dominique Cerqueira, Daniel M Parker, Gilles Cottrell, Anne Poinsignon, Franck Remoue, Cecile Brengues, Theeraphap Chareonviriyaphap, Francois Nosten, Vincent Corbel
BACKGROUND: The modalities of malaria transmission along the Thailand-Myanmar border are poorly understood. Here we address the relevance of using a specific Anopheles salivary biomarker to measure the risk of human exposure to anopheles bites. METHODS: Serologic surveys were conducted from May 2013 to December 2014 in 4 sentinel villages. Dried blood spots (n>9,400) were collected in filter papers among all inhabitants at baseline and then every three months up to 18 months...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27905280/diagnosis-and-species-discrimination-of-positive-malaria-samples-by-real-time-polymerase-chain-reaction
#14
Esra Atalay Şahar, Muhammet Karakavuk, Hüseyin Can, Şebnem Nergiz, Kadri Gül, Aysu Değirmenci Döşkaya, Yüksel Gürüz, Mert Döşkaya
OBJECTIVE: Malaria is an important tropical disease that is detected in 198 million people and causes 367-755 thousand deaths annually. Recently, the real-time Polymerase Chain Reaction (PCR) technique has enabled quick determination of Plasmodium spp. and species identification in the same assay with a low contamination risk. In the present study, we aimed to use real-time PCR targeting the 18S rRNA gene to diagnose Plasmodium spp. and perform species identification. METHODS: DNA samples of 15 patients with malaria (14 caused by P...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27899111/plasmodium-malariae-in-the-colombian-amazon-region-you-don-t-diagnose-what-you-don-t-suspect
#15
Carlos Hernando Niño, Juan Ricardo Cubides, Paola Andrea Camargo-Ayala, Carlos Arturo Rodríguez-Celis, Teódulo Quiñones, Moisés Tomás Cortés-Castillo, Lizeth Sánchez-Suárez, Ricardo Sánchez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
BACKGROUND: Malaria is a worldwide public health problem; parasites from the genus Plasmodium spp. are the aetiological agent of this disease. The parasite is mainly diagnosed by microscope-based techniques. However, these have limited sensitivity. Many asymptomatic infections are sub-microscopic and can only be detected by molecular methods. This study was aimed at comparing nested PCR results to those obtained by microscope for diagnosing malaria and to present epidemiological data regarding malaria in Colombia's Amazon department...
November 29, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27895268/credit-with-health-education-in-benin-a-cluster-randomized-trial-examining-impacts-on-knowledge-and-behavior
#16
Dean Karlan, Bram Thuysbaert, Bobbi Gray
We evaluate whether health education integrated into microcredit lending groups reduces health risks by improving health knowledge and self-reported behaviors among urban and rural borrowers in eastern Benin. In 2007, we randomly assigned 138 villages in the Plateau region of Benin to one of four variations of a group liability credit product, varying lending groups' gender composition and/or inclusion of health education using a 2 × 2 design. Women in villages receiving health education, regardless of gender composition of the groups, showed improved knowledge of malaria and of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), but not of childhood illness danger signs...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27893838/performance-evaluation-of-malaria-microscopists-at-defense-health-facilities-in-addis-ababa-and-its-surrounding-areas-ethiopia
#17
Tigist Yitbarek, Desalegn Nega, Geremew Tasew, Bineyam Taye, Kassu Desta
BACKGROUND: Blood film microscopy is the gold standard approach for malaria diagnosis, and preferred method for routine patient diagnosis in health facilities. However, the inability of laboratory professionals to correctly detect and identify malaria parasites microscopically leads to an inappropriate administration of anti-malarial drugs to the patients and incorrect findings in research areas. This study was carried out to evaluate the performance of laboratory professionals in malaria diagnosis in health facilities under the Defense Health Main Department in Addis Ababa and its surroundings, Ethiopia...
2016: PloS One
https://www.readbyqxmd.com/read/27885872/improvement-of-solubility-dissolution-and-stability-profile-of-artemether-solid-dispersions-and-self-emulsified-solid-dispersions-by-solvent-evaporation-method
#18
Muhammad Tayyab Ansari, Muhammad Sohail Arshad, Altaf Hussain, Zeeshan Ahmad
The purpose of this study was to investigate changes in the water solubility of artemether; a poorly soluble drug used for the treatment of malaria. Different solid dispersions (SDs) of artemether were prepared using artemether and polyethylene glycol 6000 at ratio 12:88 (Group 1), self-emulsified solid dispersions (SESDs) containing artemether, polyethylene glycol 6000, cremophor-A-25, olive oil, hydroxypropylmethylcellulose and transcutol in the ratio 12:75:5:4:2:2, respectively (Group 2). SESDs were also prepared by substituting cremophor-A-25 in Group 2 with poloxamer 188 (noted as Group 3)...
December 8, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27884146/demographic-and-clinical-profiles-of-plasmodium-falciparum-and-plasmodium-vivax-patients-at-a-tertiary-care-centre-in-southwestern-india
#19
Laura Chery, Jennifer N Maki, Anjali Mascarenhas, Jayashri T Walke, Pooja Gawas, Anvily Almeida, Mezia Fernandes, Marina Vaz, Rakesh Ramanan, Diksha Shirodkar, Maria Bernabeu, Suresh Kumar Manoharan, Ligia Pereira, Rashmi Dash, Ambika Sharma, Riaz Basha Shaik, Rimi Chakrabarti, Prasad Babar, John White, Devaraja G Mudeppa, Shiva Kumar, Wenyun Zuo, Kristen M Skillman, Usheer Kanjee, Caeul Lim, Kathryn Shaw-Saliba, Ashwani Kumar, Neena Valecha, V N Jindal, Anar Khandeparkar, Pradeep Naik, Sunanda Amonkar, Manoj T Duraisingh, Shripad Tuljapurkar, Joseph D Smith, Nagesh Dubhashi, Roque G W Pinto, Maria Silveria, Edwin Gomes, Pradipsinh K Rathod
BACKGROUND: Malaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out in Africa and Southeast Asia to characterize and examine determinants of Plasmodium falciparum and Plasmodium vivax malaria pathogenesis, fewer have been conducted in India. METHODS: A prospective study of malaria-positive individuals was conducted at Goa Medical College and Hospital (GMC) from 2012 to 2015 to identify demographic, diagnostic and clinical indicators associated with P...
November 25, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27882866/the-performance-of-community-health-workers-in-the-management-of-multiple-childhood-infectious-diseases-in-lira-northern-uganda-a-mixed-methods-cross-sectional-study
#20
Phillip Wanduru, Moses Tetui, Doreen Tuhebwe, Michael Ediau, Monica Okuga, Christine Nalwadda, Elizabeth Ekirapa-Kiracho, Peter Waiswa, Elizeus Rutebemberwa
BACKGROUND: Community health workers (CHWs) have the potential to reduce child mortality by improving access to care, especially in remote areas. Uganda has one of the highest child mortality rates globally. Moreover, rural areas bear the highest proportion of this burden. The optimal performance of CHWs is critical. In this study, we assess the performance of CHWs in managing malaria, pneumonia, and diarrhea in the rural district of Lira, in northern Uganda. DESIGNS: A cross-sectional mixed methods study was undertaken to investigate the performance of 393 eligible CHWs in the Lira district of Uganda...
2016: Global Health Action
keyword
keyword
98834
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"