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https://www.readbyqxmd.com/read/29347985/seasonal-and-inter-annual-variation-of-malaria-parasite-detection-in-wild-chimpanzees
#1
Doris F Wu, Therese Löhrich, Andreas Sachse, Roger Mundry, Roman M Wittig, Sébastien Calvignac-Spencer, Tobias Deschner, Fabian H Leendertz
BACKGROUND: Cross-sectional surveys of chimpanzee (Pan troglodytes) communities across sub-Saharan Africa show large geographical variation in malaria parasite (Plasmodium spp.) prevalence. The drivers leading to this apparent spatial heterogeneity may also be temporally dynamic but data on prevalence variation over time are missing for wild great apes. This study aims to fill this fundamental gap. METHODS: Some 681 faecal samples were collected from 48 individuals of a group of habituated chimpanzees (Taï National Park, Côte d'Ivoire) across four non-consecutive sampling periods between 2005 and 2015...
January 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29343279/spatial-distribution-and-habitat-characterization-of-mosquito-species-during-the-dry-season-along-the-mara-river-and-its-tributaries-in-kenya-and-tanzania
#2
Gabriel O Dida, Douglas N Anyona, Paul O Abuom, Daniel Akoko, Samson O Adoka, Ally-Said Matano, Philip O Owuor, Collins Ouma
BACKGROUND: Vector-borne diseases are increasingly becoming a major health problem among communities living along the major rivers of Africa. Although larger water bodies such as lakes and dams have been extensively researched, rivers and their tributaries have largely been ignored. This study sought to establish the spatial distribution of mosquito species during the dry season and further characterize their habitats along the Mara River and its tributaries. METHODS: In this cross-sectional survey, mosquito larvae were sampled along the Mara River, its two perennial tributaries (Amala and Nyangores), drying streams, and adjacent aquatic habitats (e...
January 18, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29338786/a-systematic-review-of-transfusion-transmitted-malaria-in-non-endemic-areas
#3
Federica Verra, Andrea Angheben, Elisa Martello, Giovanni Giorli, Francesca Perandin, Zeno Bisoffi
BACKGROUND: Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient's bloodstream triggering the development of high risk complications, and potentially leading to a fatal outcome especially in individuals with no previous exposure to malaria or in immuno-compromised patients. A systematic review was conducted on TTM case reports in non-endemic areas to describe the epidemiological characteristics of blood donors and recipients...
January 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29334956/identification-and-characterization-of-areas-of-high-and-low-risk-for-asymptomatic-malaria-infections-at-sub-village-level-in-ratanakiri-cambodia
#4
Lies Durnez, Myrthe Pareyn, Vanna Mean, Saorin Kim, Nimol Khim, Didier Menard, Marc Coosemans, Tho Sochantha, Vincent Sluydts
BACKGROUND: Malaria elimination needs a concentration of activities towards identification of residual transmission foci and intensification of efforts to eliminate the last few infections, located in so-called 'malaria hotspots'. Previous work on characterizing malaria transmission hotspots has mainly focused on falciparum malaria and especially on symptomatic cases, while the malaria reservoir is expected to be mainly concentrated in the asymptomatic human population when transmission is low...
January 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29311086/artemether-lumefantrine-for-the-treatment-of-plasmodium-malariae-plasmodium-ovale-and-mixed-plasmodium-malaria-a-prospective-clinical-trial-assessing-species-specific-efficacy-in-gabon
#5
Mirjam Groger, Luzia Veletzky, Albert Lalremruata, Chiara Cattaneo, Johannes Mischlinger, Rella Zoleko-Manego, Lilian Endamne, Anna Klicpera, Johanna Kim, The Nguyen, Lena Flohr, Jonathan Remppis, Pierre-Blaise Matsiegui, Ayôla A Adegnika, Selidji T Agnandji, Peter G Kremsner, Benjamin Mordmüller, Ghyslain Mombo-Ngoma, Michael Ramharter
ObjectivesTreatment recommendations for Plasmodium malariae and Plasmodium ovale malaria are largely based on anecdotal evidence. The aim of this study was to systematically assess the efficacy and safety of artemether-lumefantrine for the treatment of patients with uncomplicated P.malariae or P.ovale mono-infections, or mixed Plasmodium infections.Patients and methodsThis prospective study was conducted in Gabon. Patients with microscopically confirmed P.malariae, P.ovale, or mixed species malaria with at least one of these two Plasmodium species were treated with an oral, fixed dose combination of artemether-lumefantrine for three consecutive days...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310704/mapping-insecticide-resistance-in-anopheles-gambiae-s-l-from-c%C3%A3-te-d-ivoire
#6
Soromane Camara, Alphonsine A Koffi, Ludovic P Ahoua Alou, Kouakou Koffi, Jean-Paul K Kabran, Aboubacar Koné, Mathieu F Koffi, Raphaël N'Guessan, Cédric Pennetier
BACKGROUND: Insecticide resistance in malaria vectors is an increasing threat to vector control tools currently deployed in endemic countries. Resistance management must be an integral part of National Malaria Control Programmes' (NMCPs) next strategic plans to alleviate the risk of control failure. This obviously will require a clear database on insecticide resistance to support the development of such a plan. The present work gathers original data on insecticide resistance between 2009 and 2015 across Côte d'Ivoire in West Africa...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29301534/submicroscopic-malaria-cases-play-role-in-local-transmission-in-trenggalek-district-east-java-province-indonesia
#7
Heny Arwati, Subagyo Yotopranoto, Etik Ainun Rohmah, Din Syafruddin
BACKGROUND: Trenggalek district is a hypoendemic malaria area with mainly imported cases brought by migrant workers from islands outside Java. During malaria surveillance in 2015, no malaria cases were found microscopically, but some cases were positive by PCR. Therefore, a study was conducted to prove that local malaria transmission still occur. METHODS: The adult villagers were invited to the house of the head of this village to be screened for malaria using aseptic venipuncture of 1 mL blood upon informed consent...
January 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29291234/a-clinical-report-on-mixed-infection-of-malaria-dengue-and-chikungunya-from-new-delhi-india
#8
Mohd Abdullah, Ayesha Tazeen, Malik Hisamuddin, Irshad H Naqvi, Hirday N Verma, Anwar Ahmed, Shama Parveen
Arthropod-borne infections like malaria, dengue and chikungunya fever are transmitted by mosquitoes. The present report describes an unusual case of mixed infection with malaria, dengue and chikungunya viruses in a 21 year old male patient from New Delhi, India during monsoon season of 2016. The malarial fever was diagnosed by thin slide microscopy and antigen test. Chikungunya virus IgM was detected in the sample by the card test. Dengue and chikungunya viruses were further confirmed by RT-PCR for CprM and E1 gene respectively...
December 2017: Virusdisease
https://www.readbyqxmd.com/read/29261647/the-detection-of-cryptic-plasmodium-infection-among-villagers-in-attapeu-province-lao-pdr
#9
Moritoshi Iwagami, Sengdeuane Keomalaphet, Phonepadith Khattignavong, Pheovaly Soundala, Lavy Lorphachan, Emilie Matsumoto-Takahashi, Michel Strobel, Daniel Reinharz, Manisack Phommasansack, Bouasy Hongvanthong, Paul T Brey, Shigeyuki Kano
BACKGROUND: Although the malaria burden in the Lao PDR has gradually decreased, the elimination of malaria by 2030 presents many challenges. Microscopy and malaria rapid diagnostic tests (RDTs) are used to diagnose malaria in the Lao PDR; however, some studies have reported the prevalence of sub-microscopic Plasmodium infections or asymptomatic Plasmodium carriers in endemic areas. Thus, highly sensitive detection methods are needed to understand the precise malaria situation in these areas...
December 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29259824/health-system-effects-of-implementing-integrated-community-case-management-iccm-intervention-in-private-retail-drug-shops-in-south-western-uganda-a-qualitative-study
#10
Freddy Eric Kitutu, Chrispus Mayora, Emily White Johansson, Stefan Peterson, Henry Wamani, Maryam Bigdeli, Zubin Cyrus Shroff
Background: Intervening in private drug shops to improve quality of care and enhance regulatory oversight may have health system effects that need to be understood before scaling up any such interventions. We examine the processes through which a drug shop intervention culminated in positive unintended effects and other dynamic interactions within the underlying health system. Methods: A multifaceted intervention consisting of drug seller training, supply of diagnostics and subsidised medicines, use of treatment algorithms, monthly supervision and community sensitisation was implemented in drug shops in South Western Uganda, to improve paediatric fever management...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29233139/demand-related-factors-influencing-caregivers-awareness-of-malaria-tests-and-health-workers-testing-practices-in-makarfi-nigeria
#11
Olufemi Ajumobi, Kabir Sabitu, IkeOluwapo Ajayi, Patrick Nguku, Joy Ufere, Peter Wasswa, Chinwoke Isiguzo, Jennifer Anyanti, Jenny Liu
BACKGROUND: Despite the World Health Organization's recommendation of malaria test-treat strategy, which is the treatment of parasitological confirmed malaria cases with anti-malarials, presumptive diagnosis of malaria remains fairly common in Nigeria. The reasons for this have not been established in Makarfi, Nigeria, despite the high burden of malaria in the area. A study was conducted among caregivers of febrile children less than 5 years presenting for treatment to understand their awareness of malaria diagnostic testing and being offered testing by clinicians, the determinants of these outcomes, and caregivers' perspectives of health workers' testing practices...
December 12, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29209209/nonribosomal-peptides-from-marine-microbes-and-their-antimicrobial-and-anticancer-potential
#12
REVIEW
Shivankar Agrawal, Debabrata Acharya, Alok Adholeya, Colin J Barrow, Sunil K Deshmukh
Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29207762/guillain-barre-syndrome-with-falciparum-malaria-and-scrub-typhus-mixed-infection-an-unusual-combination
#13
Rahul Sai Gangula, Weena Stanley, Arunsheshu Vandanapu, M Mukhyaprana Prabhu
Guillain-Barre Syndrome is very rare in parasitic and rickettsial infection. Here we report a case of Plasmodium falciparum and scrub typhus mixed infection, presented with quadriparesis. Clinical, Serological, CSF analysis and Nerve Conduction Studies were consistent with Acute Inflammatory Demyelinating Polyneuropathy (variant of GBS). After administration of antimalarials and antibiotics for the mixed infection, patient gradually improved.
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29203789/prevalence-of-malaria-in-two-highly-endemic-community-health-centers-in-the-bastar-district-chhattisgarh-showing-mixed-infections-with-plasmodium-species
#14
Sri Krishna, Ajay Yadav, Sneha Bhandari, Anup K Vishwakarma, Praveen K Bharti, Prem L Mandavi, Pradeep Bahgel, Sanjay Basak, Ravendra K Sharma, Neeru Singh
Malaria is a major public health problem in India and in the Chhattisgarh state. The diagnosis of malaria presents a major challenge in remote areas The prevalence of malaria in Darbha and Kilepal Community Health Centers (CHCs) of the Jagdalpur district, Chhattisgarh affected by conflict was determined using microscopy and polymerase chain reaction (PCR). In the year 2015, 29.4% and 21.5% cases were found to be positive for malaria at the Darbha and Kilepal CHCs, respectively, by microscopy, and 7.4% and 1...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29186137/evaluation-of-the-implementation-fidelity-of-the-seasonal-malaria-chemoprevention-intervention-in-kaya-health-district-burkina-faso
#15
Rachidatou Compaoré, Maurice Wambi Evariste Yameogo, Tieba Millogo, Halima Tougri, Seni Kouanda
BACKGROUND: Burkina Faso implemented the seasonal malaria chemoprevention (SMC) in 2014 in seven pilot health districts, following the new recommendation by the WHO in 2012 for the prevention of the disease in children under five years old, for areas of highly seasonal malaria transmission.The objective of this study was to assess the implementation fidelity of the seasonal malaria chemoprevention strategy in one of the districts, Kaya Health District. METHODOLOGY: We conducted a case study, with a quantitative and qualitative mixed methods...
2017: PloS One
https://www.readbyqxmd.com/read/29163934/determinants-of-integrated-management-of-childhood-illness-imci-non-severe-pneumonia-classification-and-care-in-malawi-health-facilities-analysis-of-a-national-facility-census
#16
Emily White Johansson, Humphreys Nsona, Liliana Carvajal-Aguirre, Agbessi Amouzou, Helena Hildenwall
Background: Research shows inadequate Integrated Management of Childhood Illness (IMCI)-pneumonia care in various low-income settings but evidence is largely from small-scale studies with limited evidence of patient-, provider- and facility-levels determinants of IMCI non-severe pneumonia classification and its management. Methods: The Malawi Service Provision Assessment 2013-2014 included 3149 outpatients aged 2-59 months with completed observations, interviews and re-examinations...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29162120/a-village-level-cluster-randomized-entomological-evaluation-of-combination-long-lasting-insecticidal-nets-containing-pyrethroid-plus-pbo-synergist-in-southern-mali
#17
Moussa B M Cisse, Djibril Sangare, Richard M Oxborough, Abdourhamane Dicko, Dereje Dengela, Aboubacar Sadou, Jules Mihigo, Kristen George, Laura Norris, Christen Fornadel
BACKGROUND: There is growing concern that malaria vector resistance to pyrethroid insecticides may reduce the effectiveness of long-lasting insecticidal nets (LLINs). Combination LLINs are designed to control susceptible and pyrethroid-resistant mosquito populations through a mixture of pyrethroid with piperonyl butoxide (PBO) synergist. A cluster randomized trial with entomology outcome measures was conducted in Mali to determine the added benefit over mono-treated pyrethroid predecessors...
November 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29162113/determination-of-the-residual-efficacy-of-carbamate-and-organophosphate-insecticides-used-for-indoor-residual-spraying-for-malaria-control-in-ethiopia
#18
Delenasaw Yewhalaw, Meshesha Balkew, Josephat Shililu, Sultan Suleman, Alemayehu Getachew, Gedeon Ashenbo, Sheleme Chibsa, Gunawardena Dissanayake, Kristen George, Dereje Dengela, Yemane Ye-Ebiyo, Seth R Irish
BACKGROUND: Indoor residual spraying is one of the key vector control interventions for malaria control in Ethiopia. As malaria transmission is seasonal in most parts of Ethiopia, a single round of spraying can usually provide effective protection against malaria, provided the insecticide remains effective over the entire malaria transmission season. This experiment was designed to evaluate the residual efficacy of bendiocarb, pirimiphos-methyl, and two doses of propoxur on four different wall surfaces (rough mud, smooth mud, dung, and paint)...
November 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29162101/ivermectin-susceptibility-sporontocidal-effect-and-inhibition-of-time-to-re-feed-in-the-amazonian-malaria-vector-anopheles-darlingi
#19
Kevin C Kobylinski, Karín S Escobedo-Vargas, Victor M López-Sifuentes, Salomón Durand, Edward S Smith, G Christian Baldeviano, Robert V Gerbasi, Sara-Blythe Ballard, Craig A Stoops, Gissella M Vásquez
BACKGROUND: Outdoor malaria transmission hinders malaria elimination efforts in the Amazon region and novel vector control tools are needed. Ivermectin mass drug administration (MDA) to humans kills wild Anopheles, targets outdoor-feeding vectors, and can suppress malaria parasite transmission. Laboratory investigations were performed to determine ivermectin susceptibility, sporontocidal effect and inhibition of time to re-feed for the primary Amazonian malaria vector, Anopheles darlingi...
November 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29158512/wild-bonobos-host-geographically-restricted-malaria-parasites-including-a-putative-new-laverania-species
#20
Weimin Liu, Scott Sherrill-Mix, Gerald H Learn, Erik J Scully, Yingying Li, Alexa N Avitto, Dorothy E Loy, Abigail P Lauder, Sesh A Sundararaman, Lindsey J Plenderleith, Jean-Bosco N Ndjango, Alexander V Georgiev, Steve Ahuka-Mundeke, Martine Peeters, Paco Bertolani, Jef Dupain, Cintia Garai, John A Hart, Terese B Hart, George M Shaw, Paul M Sharp, Beatrice H Hahn
Malaria parasites, though widespread among wild chimpanzees and gorillas, have not been detected in bonobos. Here, we show that wild-living bonobos are endemically Plasmodium infected in the eastern-most part of their range. Testing 1556 faecal samples from 11 field sites, we identify high prevalence Laverania infections in the Tshuapa-Lomami-Lualaba (TL2) area, but not at other locations across the Congo. TL2 bonobos harbour P. gaboni, formerly only found in chimpanzees, as well as a potential new species, Plasmodium lomamiensis sp...
November 21, 2017: Nature Communications
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