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https://www.readbyqxmd.com/read/29888452/the-esophagiome-integrated-anatomical-mechanical-and-physiological-analysis-of-the-esophago-gastric-segment
#1
Jingbo Zhao, Barry McMahon, Mark Fox, Hans Gregersen
Esophageal diseases are highly prevalent and carry significant socioeconomic burden. Despite the apparently simple function of the esophagus, we still struggle to better understand its physiology and pathophysiology. The assessment of large data sets and application of multiscale mathematical organ models have gained attention as part of the Physiome Project. This has long been recognized in cardiology but has only recently gained attention for the gastrointestinal(GI) tract. The term "esophagiome" implies a holistic assessment of esophageal function, from cellular and muscle physiology to the mechanical responses that transport and mix fluid contents...
June 10, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29850166/uniportal-thoracoscopy-combined-with-laparoscopy-as-minimally-invasive-treatment-of-esophageal-cancer
#2
Francesco Paolo Caronia, Ettore Arrigo, Andrea Valentino Failla, Francesco Sgalambro, Giorgio Giannone, Attilio Ignazio Lo Monte, Massimo Cajozzo, Mario Santini, Alfonso Fiorelli
A 67-year-old man was referred to our attention for management of esophageal adenocarcinoma, localized at the level of the esophagogastric junction and obstructed the 1/3 of the esophageal lumen. Due to the extension of the disease (T3N1M0-Stage IIIA), the patient underwent neo-adjuvant chemo-radiation therapy and he was then scheduled for a minimally invasive surgical procedure including laparoscopic gastroplasty, uniportal thoracoscopic esophageal dissection and intrathoracic end-to-end esophago-gastric anastomosis...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29790061/acute-bleeding-obstruction-pancreatitis-after-roux-en-y-anastomosis-in-total-gastrectomy-a-single-center-experience
#3
J Weindelmayer, S Laiti, R La Mendola, M Bencivenga, L Scorsone, V Mengardo, S Giacopuzzi
Anastomotic intraluminal bleeding is a well-known complication after total gastrectomy. Nevertheless, few data are published on acute bleeding obstruction pancreatitis (BOP) due to a bleeding from the jejunojejunostomy (JJ). In this paper we describe our experience. A total of 140 gastrectomies for EGJ cancer were performed in our Institute from January 2012 to January 2017. All reconstructions were performed with a Roux-en-Y anastomosis: a mechanical end-to-side esophago-jejunostomy and a mechanical end-to-side JJ...
May 22, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29756656/pathophysiology-and-treatment-of-achalasia-in-a-muscle-mechanical-perspective
#4
REVIEW
Hans Gregersen, Kar Man Lo
This review provides a biomechanical perspective on the pathophysiology and treatment of achalasia. The esophagus is efficient in transporting ingested material to the stomach in healthy subjects. A fine balance exists between the peristaltic forces generated in the esophageal body (which herein is defined as the preload) and the resistance in the outlet, the esophago-gastric junction (which is defined as the afterload). Achalasia is a rare esophageal disease that progressively over many years challenges esophageal efficacy...
May 14, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29696519/esophago-pericardial-fistula-with-development-of-hydro-pneumo-pericardium-resulting-in-hemodynamic-instability-an-unusual-complication-of-esophageal-cancer
#5
Toseef Javaid, Zubair Khan, Syed Hasan, Nauman Siddiqui, Ali Nawras
No abstract text is available yet for this article.
April 25, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29681019/high-percentage-pathological-findings-in-obese-patients-suggest-that-esophago-gastro-duodenoscopy-should-be-made-mandatory-prior-to-bariatric-surgery
#6
Mizelle D'Silva, Aparna Govil Bhasker, Nimisha S Kantharia, Muffazal Lakdawala
ᅟ: Obesity is a global epidemic and will soon become the number one priority in healthcare management. Bariatric surgery causes a significant improvement in obesity and its related complications. Pre-operative esophago-gastro-duodenoscopy (EGD) is done by several bariatric surgical teams across the world but is still not mandatory. AIM: To study the percentage of symptomatic and asymptomatic pathological EGD findings in obese patients undergoing bariatric surgery and to analyze whether these findings influence the eventual choice of bariatric surgery...
April 21, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29679342/fundoplication-with-180-degree-wrap-during-esophagogastrostomy-after-robotic-proximal-gastrectomy-for-early-gastric-cancer
#7
Toshiyasu Ojima, Mikihito Nakamori, Masaki Nakamura, Keiji Hayata, Shimpei Maruoka, Hiroki Yamaue
BACKGROUND: Compared with total gastrectomy, proximal gastrectomy (PG) has potential advantages from a nutritional perspective, such as anemia and postoperative loss of body weight. However, PG is associated with some postoperative functional disorders, such as reflux esophagus (13-31%) and anastomotic stenosis (3-29%).1 We therefore developed a new procedure for fundoplication during esophago-gastrostomy after robotic PG (RPG). METHODS: We performed RPG for early gastric cancer localized in the upper third of the stomach using the da Vinci Surgical System (Intuitive, Sunnyvale, CA)...
April 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29629892/does-digestive-symptoms-require-esophago-gastroscopy-prior-to-bariatric-procedure-assessment-of-6-years-experience
#8
Serdar Yormaz, Kafali Yilmaz, Husnu Alptekin, Ilhan Ece, Fahrettin Acar, Bayram Colak, Mehmet Ertugrul Kafali, Enes Sahin, Mustafa Sahin
AIM: Performance of routine preoperative esophagogastroduodenal endoscopy (EGE) in patients undergoing bariatric surgery is still a controversial subject. The purpose of our study was to evaluate the benefits of performing preoperative EGE in a cohort of bariatric patients. MATERIAL AND METHODS: The present retrospective study was performed between March 2010 and June 2016. We divided the study participants into two groups: group A comprised subjects without disturbing upper digestive signs, while group B comprised patients with disturbing upper digestive signs...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29607389/the-diagnostic-yield-of-open-access-endoscopy-of-the-upper-gastrointestinal-tract-in-the-netherlands
#9
Femke Crouwel, M M Meurs-Szojda, M Klemt-Kropp, P Fockens, M E Grasman
Background and study aims : Since the introduction of open-access esophago-gastroduodenoscopy (OAE) there is an increase in the total number of performed OAEs whilst the frequency of clinical relevant findings has decreased. The aim of this study was to assess the appropriate use and the diagnostic yield of OAE in the Netherlands and to determine which patient variables are able to predict a malignant finding. Patients and methods : A retrospective chart review of all referrals for diagnostic OAE between October 2012 and October 2016 at the Northwest Clinics was performed...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29605981/axial-movements-and-length-changes-of-the-human-lower-esophageal-sphincter-during-respiration-and-distension-induced-secondary-peristalsis-using-functional-luminal-imaging-probe
#10
Donghua Liao, Christian Lottrup, Lotte Fynne, Barry P McMahon, Klaus Krogh, Asbjørn M Drewes, Jingbo Zhao, Hans Gregersen
Background/Aims: Efficient transport through the esophago-gastric junction (EGJ) requires synchronized circular and longitudinal muscle contraction of the esophagus including relaxation of the lower esophageal sphincter (LES). However, there is a scarcity of technology for measuring esophagus movements in the longitudinal (axial) direction. The aim of this study is to develop new analytical tools for dynamic evaluation of the length change and axial movement of the human LES based on the functional luminal imaging probe (FLIP) technology and to present normal signatures for the selected parameters...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29603510/esophageal-provocation-tests-are-they-useful-to-improve-diagnostic-yield-of-high-resolution-manometry
#11
REVIEW
D A Carlson, S Roman
High resolution manometry (HRM) is the gold standard to diagnose esophageal motility disorders but has some limitations. The inclusion of provocative tests might enhance the diagnostic yield of HRM. These tests are easy to perform and to add to the regular manometry protocol. Multiple rapid swallows (MRS; 5 2-mL swallows) is useful to assess the contractile reserve and deglutitive inhibition. The optimal number of MRS to perform might be 3 as suggested by Mauro et al. in this issue of Neurogastroenterology & Motility...
April 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29562417/-experiences-of-esophageal-replacement-with-ileocolon-graft-a-series-of-34-cases
#12
X F Guo, R Hua, Y F Sun, Y Yang, B Ye, B Li, H Y Gu, X B Zhang, T Mao, Z G Li
Objective: To evaluate the safety and effectiveness of esophageal replacement with ileocolon graft. Methods: Totally 34 cases of esophageal replacement with ileocolon graft from July 2015 to November 2017 at Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University were analyzed retrospectively, including 24 male and 10 female, aging from 7 to 72 years old. Esophageal replacement with ileocolon graft by right and/or middle colic artery as a blood supply using retrosternal route except one subcutaneous route...
April 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29544370/predictive-biomarkers-for-the-treatment-of-resectable-esophageal-and-esophago-gastric-junction-adenocarcinoma-from-hypothesis-generation-to-clinical-validation
#13
Geny Piro, Carmine Carbone, Raffaela Santoro, Giampaolo Tortora, Davide Melisi
Esophageal and esophago-gastric junction (EGJ) adenocarcinomas remain a major health problem worldwide with a worryingly increasing incidence. Recent trials indicate survivals benefit for preoperative or perioperative chemoradiotherapy compared to surgery alone. Beside standard chemoradiotherapy regimens, new therapeutic approaches with targeted therapies have been proposed for the treatment of resectable disease. However, clinical outcomes remain extremely poor due to drug resistance phenomena. The failure of these approaches could be partially ascribed to their incorrect application in patients...
April 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29526040/esophagojejunal-anastomotic-dehiscence-successfully-repaired-by-endoluminal-suture-and-stent-positioning-report-of-a-mini-invasive-approach
#14
Antonino Granata, Michele Amata, Mario Traina
No abstract text is available yet for this article.
March 11, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29509537/endoscopic-treatment-of-benign-esophageal-fistulas-using-fully-covered-metallic-esophageal-stents
#15
Denisa Oprisanescu, Denisa Bucur, Vasile Sandru, Ioan Cristian Nedelcu, Madalina Ilie, Ruxandra Oprita, Gabriel Constantinescu
Non-malignant esophageal fistulas have a wide spectrum of clinical and pathological features and it`s important to learn to detect and treat them, due to significant morbidity, mortality and costs. The need for minimally invasive, efficient and also quick procedures is imperative. Esophageal stenting using fully-covered expandable stents has become an increasingly preferred option and addresses to fistulas which arise from 2-3 cm beyond Killian's mouth and up to the gastroesophageal junction. The long-term purpose of the procedure is closure of the fistula and thus healing...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29492088/aaa-syndrome-case-report-of-a-rare-disease
#16
S Waqar H Shah, Arshad K Butt, K Malik, Altaf Alam, Adnan Shahzad, Anwaar A Khan
Triple A (Allgrove) syndrome, an autosomal recessive disease is characterized by achalasia, alacrimia and ACTH-resistant adrenal failure with progressive neurological syndrome including central, peripheral and autonomic nervous system impairment, and mild mental retardation. The triple A syndrome gene, designated AAAS, localized on chromosome 12q 13 encodes for a 546 amino acid protein called ALADIN (Alacrimia-Achlasia-Adrenal Insufficiency and Neurologic disorder). This report relates to two sisters, aged 8 and 12 years, who had vomiting, muscle weakness, alacrimia, excessive fatigue and dysphagia...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29459017/poor-performance-in-incremental-shuttle-walk-and-cardiopulmonary-exercise-testing-predicts-poor-overall-survival-for-patients-undergoing-esophago-gastric-resection
#17
Jessica Whibley, Christopher J Peters, Laura J Halliday, Asif M Chaudry, William H Allum
INTRODUCTION: Esophageal and gastric cancer have a poor prognosis and surgical intervention is associated with considerable morbidity, highlighting the need for careful preoperative assessment. The Incremental Shuttle Walk Test (ISWT) and Cardiopulmonary exercise testing (CPET) can assess preoperative fitness. This study aims to investigate their correlation with both postoperative respiratory complications and overall survival. PATIENTS AND METHODS: Patients were identified who underwent esophageal or gastric resections for cancer between 2010 and 2014 and had ISWT and/or CPET assessments...
May 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29413875/neoadjuvant-chemotherapy-in-advanced-gastric-and-esophago-gastric-cancer-meta-analysis-of-randomized-trials
#18
REVIEW
Federico Coccolini, Matteo Nardi, Giulia Montori, Marco Ceresoli, Andrea Celotti, Stefano Cascinu, Paola Fugazzola, Matteo Tomasoni, Olivier Glehen, Fausto Catena, Yutaka Yonemura, Luca Ansaloni
INTRODUCTION: Even in after curative surgery and adequate linfoadenectomy the survival of advanced gastric cancer (AGC) remains poor. At present some data have been published on the effects of NACT and perioperative chemotherapy on AGC and Esophago-gastric cancer (EGC) but not definitive ones. The present meta-analysis aims to evaluate the effects of neoadjuvant chemotherapy (NACT) on the AGC and EGC. MATERIAL AND METHODS: A systematic review with meta-analysis of randomized controlled trials (RCTs) of NACT + surgery vs...
March 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29399174/prognoses-of-advanced-esophago-gastric-junction-cancer-may-be-modified-by-thoracotomy-and-splenectomy
#19
Kei Hosoda, Keishi Yamashita, Harukazu Tsuruta, Hiromitsu Moriya, Hiroaki Mieno, Akira Ema, Marie Washio, Masahiko Watanabe
Globally, the incidence of esophago-gastric junction (EGJ) cancer is rapidly increasing. However, the proposed strategies for the treatment of these types of cancer are so diverse that there is no established consensus on the optimal treatment. The aim of the present study was to identify independent prognostic factors to delineate the optimal strategies for the treatment of EGJ cancer. The medical records of 150 patients with EGJ cancer who underwent curative surgery at the Kitasato University were retrospectively reviewed...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29394844/-a-case-of-qol-improvement-after-intestinal-stenosis-due-to-peritoneal-dissemination-of-gastric-cancer-in-elderly-patients
#20
Katsumi Shimomura, Yuki Furuke, Yukie Tanaka, Tatsuya Kumano, Syuhei Komatsu, Kenichiro Imura, Jun Ikeda, Fumihiro Taniguchi, Yasuhiro Shioaki, Yoshikazu Nakatsugawa
Nearly 70% of gastric cancer recurrences occur as peritoneal dissemination. Most of the treatment for recurrence of gastric cancer dissemination is chemotherapy; depending on the symptoms and the site of recurrence, palliative bypass surgery may be performed. Intensive treatment is often difficult for elderly patients over 85-years-old. This case was a 91-year-old female who underwent total gastrectomy for gastric cancer(signet-ring cell carcinoma)7years prior. Two years ago, a stenosis due to recurrence was revealed in the small intestine and bypass surgery was performed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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