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https://www.readbyqxmd.com/read/28096517/the-nucleoside-analog-clitocine-is-a-potent-and-efficacious-readthrough-agent
#1
Westley J Friesen, Christopher R Trotta, Yuki Tomizawa, Jin Zhuo, Briana Johnson, Jairo Sierra, Bijoyita Roy, Marla Weetall, Jean Hedrick, Josephine Sheedy, James Takasugi, Young-Choon Moon, Suresh Babu, Ramil Baiazitov, John D Leszyk, Thomas W Davis, Stuart W Peltz, Ellen M Welch
Nonsense mutations resulting in a premature stop codon in an open reading frame occur in critical tumor suppressor genes in a large number of the most common forms of cancers and are known to cause or contribute to the progression of disease. Low molecular weight compounds that induce readthrough of nonsense mutations offer a new means of treating patients with genetic disorders or cancers resulting from nonsense mutations. We have identified the nucleoside analog clitocine as a potent and efficacious suppressor of nonsense mutations...
January 17, 2017: RNA
https://www.readbyqxmd.com/read/28053633/addition-of-digital-breast-tomosynthesis-to-full-field-digital-mammography-in-the-diagnostic-setting-additional-value-and-cancer-detectability
#2
Mirinae Seo, Jung Min Chang, Sun Ah Kim, Won Hwa Kim, Ji He Lim, Su Hyun Lee, Min Sun Bae, Hye Ryoung Koo, Nariya Cho, Woo Kyung Moon
PURPOSE: The purpose of this study was to assess the value of adding digital breast tomosynthesis (DBT) to full-field digital mammography (FFDM) in the diagnostic workup of breast cancer and to determine which lesion variables affect cancer detectability in the combined modality. METHODS: Between March and May 2012, paired FFDM and DBT images were obtained from 203 women as part of a diagnostic workup for breast cancer. Images from FFDM alone, DBT alone, and DBT combined with FFDM were reviewed in separate sessions by six blinded readers...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28038812/hopelessness-among-adults-with-congenital-heart-disease-cause-for-despair-or-hope
#3
Bahareh Eslami, Adrienne H Kovacs, Philip Moons, Kyomars Abbasi, Jamie L Jackson
BACKGROUND: Adults with congenital heart disease (CHD) face unique life courses and challenges that may negatively influence their psychological functioning. The aims of this study were to (1) examine the level of hopelessness among adults with CHD in comparison with non-CHD participants and (2) identify correlates of elevated hopelessness among adults with CHD. METHODS: We enrolled 347 patients with CHD (18-64years, 52.2% female) and 353 matched (by sex/age) non-CHD persons in this cross-sectional study...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28008358/impact-of-microvascular-obstruction-on-semiautomated-techniques-for-quantifying-acute-and-chronic-myocardial-infarction-by-cardiovascular-magnetic-resonance
#4
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Shane Weinmann, Alex Sirker, Anna S Herrey, Charlotte Manisty, James C Moon, Derek J Hausenloy
AIMS: The four most promising semiautomated techniques (5-SD, 6-SD, Otsu and the full width half maximum (FWHM)) were compared in paired acute and follow-up cardiovascular magnetic resonance (CMR), taking into account the impact of microvascular obstruction (MVO) and using automated extracellular volume fraction (ECV) maps for reference. Furthermore, their performances on the acute scan were compared against manual myocardial infarct (MI) size to predict adverse left ventricular (LV) remodelling (≥20% increase in end-diastolic volume)...
2016: Open Heart
https://www.readbyqxmd.com/read/28008162/endoscopic-approach-for-major-complications-of-bariatric-surgery
#5
Moon Kyung Joo
As lifestyle and diet patterns have become westernized in East Asia, the prevalence of obesity has rapidly increased. Bariatric surgeries, such as Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and laparoscopic adjustable gastric banding (LAGB), are considered the first-line treatment option in patients with severe obesity. However, postoperative complications have increased and the proper management of these complications, including the use of endoscopic procedures, has become important. The most serious complications, such as leaks and fistulas, can be treated with endoscopic stent placement and injection of fibrin glue, and a novel full-thickness closure over-the-scope clip (OTSC) has been used for treatment of postoperative leaks...
December 23, 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/28002650/discovery-of-short-linear-motif-mediated-interactions-through-phage-display-of-intrinsically-disordered-regions-of-the-human-proteome
#6
Norman E Davey, Moon-Hyeong Seo, Vikash Kumar Yadav, Jouhyun Jeon, Satra Nim, Izabella Krystkowiak, Cecilia Blikstad, Debbie Dong, Natalia Markova, Philip M Kim, Ylva Ivarsson
The intrinsically disordered regions of eukaryotic proteomes are enriched in short linear motifs (SLiMs), which are of crucial relevance for cellular signaling and protein regulation; many mediate interactions by providing binding sites for peptide-binding domains. The vast majority of SLiMs remain to be discovered highlighting the need for experimental methods for their large-scale identification. We present a novel proteomic peptide phage display (ProP-PD) library that displays peptides representing the disordered regions of the human proteome, allowing direct large-scale interrogation of most potential binding SLiMs in the proteome...
December 21, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27995759/hydrogel-functionalized-janus-membrane-for-skin-regeneration
#7
Young-Hyeon An, Seung Jung Yu, In Seon Kim, Su-Hwan Kim, Jeong-Mi Moon, Seunghyun L Kim, Young Hwan Choi, Joon Sig Choi, Sung Gap Im, Kyung Eun Lee, Nathaniel S Hwang
In this study, a hydrogel functionalized Janus membrane is developed and its capacity is examined as a wound dressing biomaterial. A hydrophobic fluoropolymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl methacrylate) (PHFDMA), is uniformly coated onto macroporous polyester membrane through initiated chemical vapor deposition process on both sides. PHFDMA-coated macroporous membrane exhibits antibacterial property, allows air permeation, and inhibits water penetration. Janus membrane property is obtained by exposing one side of PHFDMA coated membrane with 1 m KOH solution, which allows PHFDMA cleavage resulting in carboxylic acid residue...
December 20, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27940294/long-term-performance-and-bacterial-community-dynamics-in-biocovers-for-mitigating-methane-and-malodorous-gases
#8
Eun-Hee Lee, Kyung-Eun Moon, Kyung-Suk Cho
The long-term performance of lab-scale biocovers for the simulation of engineered landfill cover soils was evaluated. Methane (CH4), trimethylamine (TMA), and dimethyl sulfide (DMS) were introduced into the biocovers as landfill gases for 134 days and the removal performance was evaluated. The biocover systems were capable of simultaneously removing methane, TMA, and DMS. Methane was mostly eliminated in the top layer of the systems, while TMA and DMS were removed in the bottom layer. Overall, the methane removal capacity and efficiency were 224...
January 20, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/27928860/physical-activity-subjective-sleep-quality-and-time-in-bed-do-not-vary-by-moon-phase-in-german-adolescents
#9
Maia P Smith, Marie Standl, Holger Schulz, Joachim Heinrich
Lunar periodicity in human biology and behaviour, particularly sleep, has been reported. However, estimated relationships vary in direction (more or less sleep with full moon) if they exist at all, and studies tend to be so small that there is potential for confounding by weekly or monthly cycles. Lunar variation in physical activity has been posited as a driver of this relationship, but is likewise not well studied. We explore the association between lunar cycle, sleep and physical activity in a population-based sample of 1411 Germans age 14-17 years (46% male)...
December 8, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27912006/cascading-effects-of-predation-risk-determine-how-marine-predators-become-terrestrial-prey-on-an-oceanic-island
#10
Sarah K Thomsen, David J Green
Apex predators can suppress the foraging activity of mesopredators, which may then result in cascading benefits for the prey of those mesopredators. We studied the interactions between a top predator, the Barn Owl (Tyto alba), and their primary prey, an island endemic deer mouse (Peromyscus maniculatus elusus), which in turn consumes the eggs of seabirds nesting on Santa Barbara Island in California. Scripps's Murrelets (Synthliboramphus scrippsi), a threatened nocturnal seabird, arrive annually to breed on this island, and whose first egg is particularly vulnerable to predation by mice...
December 2016: Ecology
https://www.readbyqxmd.com/read/27904731/clinical-usefulness-of-long-term-application-of-fentanyl-matrix-in-chronic-non-cancer-pain-improvement-of-pain-and-physical-and-emotional-functions
#11
Jaewon Lee, Joon Shik Yoon, Jae Hyup Lee, So-Hak Chung, Kyu-Yeol Lee, Young Yul Kim, Jong Moon Kim, Min Ho Kong, Ung Gu Kang, Ye-Soo Park
BACKGROUND: Opioids are recently recommended for those who do not gain adequate pain relief from the use of acetaminophen or nonsteroidal anti-inflammatory drugs. Medical opioids are administered in various routes, and transdermal opioid products that can make up for the weaknesses of the oral or intravenous products have been developed. This study is to evaluate the clinical usefulness of fentanyl matrix in terms of the long-term improvement in pain and physical and mental functions...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27895241/secular-pattern-of-aneurismal-rupture-with-the-lunar-cycle-and-season
#12
Jillian C Banfield, Mohamed Abdolell, Jai S Shankar
BACKGROUND: The lunar cycle and seasons may be associated with rates of rupture of intracranial aneurysms, but the literature is mixed. Studies of the association between the lunar cycle and rates of aneurysm rupture used the eight qualitative moon phases. The purpose of this study was to assess any association of aneurysm rupture with the lunar cycle and with the season. MATERIALS AND METHODS: We retrospectively reviewed all cases of subarachnoid haemorrhage secondary to ruptured intracranial aneurysm treated with endovascular coiling in our institution over a 10-year period...
November 28, 2016: Interventional Neuroradiology
https://www.readbyqxmd.com/read/27889485/safety-and-effectiveness-of-anterior-fundoplication-sleeve-gastrectomy-in-patients-with-severe-reflux
#13
Rena C Moon, Andre F Teixeira, Muhammad A Jawad
BACKGROUND: Laparoscopic sleeve gastrectomy has become a popular bariatric surgery in recent years. However, it has been linked to worsening or newly developed gastroesophageal reflux disease (GERD) in the postoperative period. OBJECTIVES: The purpose of this study is to determine the safety and effectiveness of anterior fundoplication sleeve gastrectomy in patients with reflux. SETTING: Academic hospital, United States. METHODS: We prospectively collected data on 31 sleeve gastrectomy patients who concurrently underwent anterior fundoplication between July 2014 and March 2016...
October 17, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27867809/fixation-of-split-thickness-skin-graft-using-fast-clotting-fibrin-glue-containing-undiluted-high-concentration-thrombin-or-sutures-a-comparison-study
#14
Hyun Ho Han, Daiwon Jun, Suk-Ho Moon, In Sook Kang, Min Cheol Kim
OBJECTIVE: For skin defects caused by full-thickness burns, trauma, or tumor tissue excision, skin grafting is one of the most convenient and useful treatment methods. In this situation, graft fixation is important in skin grafting. This study was performed to compare the effectiveness of skin graft fixation between high-concentration fibrin sealant and sutures. There have been numerous studies using fibrin sealant for graft fixation, but they utilized slow-clotting fibrin sealant containing less than 10 IU/mL thrombin...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27867795/magnetic-reconnection-in-saturn-s-magnetotail-a-comprehensive-magnetic-field-survey
#15
A W Smith, C M Jackman, M F Thomsen
Reconnection within planetary magnetotails is responsible for locally energizing particles and changing the magnetic topology. Its role in terms of global magnetospheric dynamics can involve changing the mass and flux content of the magnetosphere. We have identified reconnection related events in spacecraft magnetometer data recorded during Cassini's exploration of Saturn's magnetotail. The events are identified from deflections in the north-south component of the magnetic field, significant above a background level...
April 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27865032/intravoxel-incoherent-motion-diffusion-weighted-mri-of-the-abdomen-the-effect-of-fitting-algorithms-on-the-accuracy-and-reliability-of-the-parameters
#16
Hyo Jung Park, Yu Sub Sung, Seung Soo Lee, Yedaun Lee, Hyunhee Cheong, Yeong Jae Kim, Moon-Gyu Lee
PURPOSE: To evaluate the influence of fitting methods on the accuracy and reliability of intravoxel incoherent motion (IVIM) parameters, with a particular emphasis on the constraint function. MATERIALS AND METHODS: Diffusion-weighted (DW) imaging data were analyzed using IVIM-based full-fitting (simultaneous fit of all parameters) and segmented-fitting (step-by-step fit of each parameter), each with and without the constraint function, to estimate the molecular diffusion coefficient (Dslow ), perfusion fraction (f), and flow-related diffusion coefficient (Dfast )...
November 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27846859/attenuation-of-the-virulence-of-a-recombinant-influenza-virus-expressing-the-naturally-truncated-ns-gene-from-an-h3n8-equine-influenza-virus-in-mice
#17
Woonsung Na, Kwang-Soo Lyoo, Sun-Woo Yoon, Minjoo Yeom, Bokyu Kang, Hyoungjoon Moon, Hye Kwon Kim, Dae Gwin Jeong, Jeong-Ki Kim, Daesub Song
Equine influenza virus (EIV) causes a highly contagious disease in horses and other equids. Recently, we isolated an H3N8 EIV (A/equine/Kyonggi/SA1/2011) from a domestic horse in South Korea that exhibited symptoms of respiratory disease, and found that the EIV strain contained a naturally mutated NS gene segment encoding a truncated NS1 protein. In order to determine whether there was an association between the NS gene truncation and viral virulence, a reverse genetics system was applied to generate various NS gene recombinant viruses using the backbone of the H1N1 A/Puerto Rico/8/1934 (PR/8) virus...
November 15, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27844482/conditions-and-calibration-to-obtain-comparable-gray-values-between-different-clinical-cone-beam-computed-tomography-scanners
#18
Gregory M England, Eun-Sang Moon, Jordan Roth, Toru Deguchi, Allen R Firestone, F Michael Beck, Do-Gyoon Kim
OBJECTIVES: The objective of the current study was to examine the gray value parameters and their magnitudes produced by cone beam computed tomography (CBCT) and whether they are influenced by different scanners with various scanning conditions. METHODS: ATOM Max dental and diagnostic artificial head was scanned by two CBCT scanners (Planmeca and iCAT). Under full field of view with a normal dose and an ultra-low dose (ULD) conditions, Planmeca examined for 3 scanning resolutions (200, 400, and 600 micron voxel sizes) and iCAT scanners tested for 4 scanning resolutions (200, 250, 300 and 400 micron voxel sizes)...
November 15, 2016: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/27828274/interference-data-correction-methods-for-lunar-observation-with-a-large-aperture-static-imaging-spectrometer
#19
Geng Zhang, Shuang Wang, Libo Li, Xiuqing Hu, Bingliang Hu
The lunar spectrum has been used in radiometric calibration and sensor stability monitoring for spaceborne optical sensors. A ground-based large-aperture static image spectrometer (LASIS) can be used to acquire the lunar spectral image for lunar radiance model improvement when the moon orbits over its viewing field. The lunar orbiting behavior is not consistent with the desired scanning speed and direction of LASIS. To correctly extract interferograms from the obtained data, a translation correction method based on image correlation is proposed...
November 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27809684/association-between-changes-in-thyroid-hormones-and-incident-type-2-diabetes-a-seven-year-longitudinal-study
#20
Ji Eun Jun, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee, Tae Hyuk Kim, Sun Wook Kim, Jae Hyeon Kim
BACKGROUND: Thyroid hormones are important regulators of glucose homeostasis. However, the association between thyroid hormones within the reference range and type 2 diabetes mellitus (T2DM) remains unclear. The aim of this study was to clarify the incidence of T2DM according to the baseline levels and changes of thyrotropin (TSH) and thyroid hormones (free thyroxine and triiodothyronine) in euthyroid subjects. METHODS: Among the participants who consecutively underwent thyroid function tests between 2006 and 2012 through a yearly health checkup program, 6235 euthyroid subjects (3619 men and 2616 women) without T2DM were enrolled in the study...
January 2017: Thyroid: Official Journal of the American Thyroid Association
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