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https://www.readbyqxmd.com/read/28945048/-glass-transition-of-chinese-medicine-extract-powder-and-its-application
#1
Xiao-Jian Luo, Hui Liu, Hong-Bo Liang, Lei Xiong, Xiao-Yong Rao, Yin Xie, Yan He
Glass transition theory is an important theory in polymer science, which is used to characterize the physical properties. It refers to the transition of amorphous polymer from the glassy state to the rubber state due to heating or the transition from rubber state to glassy state due to cooling. In this paper, the glassy state and glass transition of food and the similar relationship between the composition of Chinese medicine extract powder and food ingredients were described; the determination method for glass transition temperature (Tg) of Chinese medicine extract powder was established and its main influencing factors were analyzed...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945018/-expert-consensus-on-the-design-and-implementation-of-clinical-safety-centralized-monitoring-study-of-chinese-medical-injection
#2
Jun-Hua Zhang, Jing-Tian Ren, Jing-Qing Hu, Yan-Ming Xie, Hai-Bo Song, Ming-Jun Zhu, Rui Gao, Zhong Wang, Wen-Ke Zheng, Xue-Lin Li, Meng Jiang, Yu-Hong Huang, Fang Lu, Li-Yun He, Wei-Xiong Lian, Zhong-Qi Yang, Wei-An Yuan, Si-Yuan Hu, Bao-He Wang, Wei-Liang Wang, De-Quan Ren, Bo-Li Zhang
Along with the increase of clinical application, the safety of traditional Chinese medicine gained more and more attentions. In particular, the safety evaluation of Chinese medical injections has become a mandatory task should be completed by pharmaceutical companies under the supervision of China Food and Drug Administration(CFDA). Due to the weak foundation of previous studies, the safety issues of Chinese medical injections have not been fully understood, and lack of scientific and rational risk management programs...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944899/smilax-glabra-rhizoma-affects-the-pharmacokinetics-and-tissue-distribution-of-methotrexate-by-increasing-the-p%C3%A2-glycoprotein-mrna-expression-in-rats-after-oral-administration
#3
Yang Li, Shigui Deng, Ya Ζhao, Lijuan Liu, Ruizhi Zhao
Methotrexate (MTX) is a widely used immunosuppressant and anticancer agent with high toxicity. Smilax glabra Rhizoma (SGR) has the effect of detoxification and immunoregulation, and has been used as both food and folk medicine in many countries. Co‑administration of MTX and SGR occurs in several diseases. However, whether they work synergistically or are incompatible remains unknown. In the present study, MTX was administrated to rats alone or combined with SGR. Blood and tissue samples were collected at designated times...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28943112/update-on-food-safety-of-monosodium-l-glutamate-msg
#4
REVIEW
Helen Nonye Henry-Unaeze
OBJECTIVE: This evidence-based safety review of the flavor enhancer monosodium l-glutamate (MSG) was triggered by its global use and recent studies expressing some safety concerns. METHODOLOGY: This article obtained information through search of evidence-based scientific databases, especially the US National Library of Medicine NIH. RESULTS: (A) MSG is a water-soluble salt of glutamate, a non-essential amino acid, normally synthesized in the body and prevalent in protein foods...
September 18, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28940866/pharmacologically-controlled-drinking-in-the-treatment-of-alcohol-dependence-or-alcohol-use-disorders-a-systematic-review-with-direct-and-network-meta-analyses-on-nalmefene-naltrexone-acamprosate-baclofen-and-topiramate
#5
REVIEW
Clément Palpacuer, Renan Duprez, Alexandre Huneau, Clara Locher, Rémy Boussageon, Bruno Laviolle, Florian Naudet
BACKGROUND AND AIMS: Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders (AUDs) is an emerging concept. Our objective was to explore the comparative effectiveness of drugs used in this indication. DESIGN: Systematic review with direct and network meta-analysis of double-blind randomized controlled trials (RCTs) assessing the efficacy of nalmefene, naltrexone, acamprosate, baclofen or topiramate in non-abstinent adults diagnosed with alcohol dependence or AUDs...
September 20, 2017: Addiction
https://www.readbyqxmd.com/read/28939523/modeling-of-ultrasound-assisted-extraction-characterization-and-in-vitro-pharmacological-potential-of-polysaccharides-from-vaccinium-arctostaphylos-l
#6
Hossein Jooyandeh, Mohammad Noshad, Reza Amir Khamirian
In the study, Box-Behnken design was used to optimized the operational parameters involved in ultrasound-assisted extraction (UAE) of Vaccinium arctostaphylos polysaccharide (VAP) including ultrasound power, extraction temperature and time and water to raw material ratio. The highest extraction polysaccharide was obtained at 100W, 19.12min, 79.32C and 20 (ml water/g powdered Vaccinium arctostaphylos). Under these condition, total anthocyanin, total phenolic contents and total flavonoid were 10.16 mlg/g, 0.43 mlg/g and 0...
September 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28939508/purification-characterization-and-immunomodulatory-activity-of-water-extractable-polysaccharides-from-the-swollen-culms-of-zizania-latifolia
#7
Mingchun Wang, Shiwei Zhao, Peilei Zhu, Chenzhipeng Nie, Shuping Ma, Naifu Wang, Xianfeng Du, Yibin Zhou
The swollen culms of Zizania latifolia is a popular vegetable and traditional herbal medicine mainly consumed in some Asian countries. In our previous study, water extractable polysaccharide (ZLPs-W) and alkali extractable polysaccharide (ZLPs-A) was sequentially prepared from the swollen culms of Zizania latifolia. In vitro cell assay revealed that ZLPs-W without cytotoxicity had higher immunomodulatory activity than ZLPs-A. Therefore, in this study, ZLPs-W was further separated to three purified polysaccharides of ZLPs-W1, ZLPs-W2, and ZLPs-W3 by anion exchange chromatography and size exclusive chromatography in sequence...
September 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28938890/systematic-pathway-engineering-of-corynebacterium-glutamicum-s9114-for-l-ornithine-production
#8
Bin Zhang, Miao Yu, Ying Zhou, Yixue Li, Bang-Ce Ye
BACKGROUND: L-Ornithine is a non-protein amino acid with extensive applications in medicine and the food industry. Currently, L-ornithine production is based on microbial fermentation, and few microbes are used for producing L-ornithine owing to unsatisfactory production titer. RESULTS: In this study, Corynebacterium glutamicum S9114, a high glutamate-producing strain, was developed for L-ornithine production by pathway engineering. First, argF was deleted to block L-ornithine to citrulline conversion...
September 22, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28935287/past-present-and-future-of-pharmacotherapy-for-obesity
#9
David Benaiges, Juan Pedro-Botet, Juana A Flores-Le Roux, Elisenda Climent, Albert Goday
Conventional treatment for obesity with diet, exercise and bariatric surgery has limitations; thus, it is necessary to have pharmacological tools. In the past, different drugs were marketed that were withdrawn due to safety problems. There are currently 3 drugs approved by the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) for obesity therapy (orlistat, combination of bupropion and delayed-release naltrexone and liraglutide) and two more only authorized by FDA (lorcaserin and the combination of phentermine and extended release topiramate)...
September 18, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28935151/consumption-of-garlic-and-lemon-aqueous-extracts-combination-reduces-tumor-burden-by-angiogenesis-inhibition-apoptosis-induction-and-immune-system-modulation
#10
Wamidh H Talib
OBJECTIVES: Dietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine. The aim of the present study was to investigate the anticancer effect of the administration of garlic and lemon aqueous extracts against breast cancer implanted in mice. METHODS: We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay to determine the antiproliferative effect of both extracts and their combinations...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28934301/microwave-bio-sensor-based-on-symmetrical-split-ring-resonator-with-spurline-filters-for-therapeutic-goods-detection
#11
Rammah A Alahnomi, Z Zakaria, E Ruslan, S R Ab Rashid, Amyrul Azuan Mohd Bahar, Azizah Shaaban
A novel symmetrical split ring resonator (SSRR) based microwave sensor with spurline filters for detecting and characterizing the properties of solid materials has been developed. Due to the weak perturbation in the interaction of material under test (MUT) and planar microwave sensor, spurline filters were embedded to the SSRR microwave sensor which effectively enhanced Q-factor with suppressing the undesired harmonic frequency. The spurline filter structures force the presented sensor to resonate at a fundamental frequency of 2...
2017: PloS One
https://www.readbyqxmd.com/read/28933978/the-glycosidase-treatment-of-gentianae-scabrae-radix-converts-trifloroside-into-deglucosyltrifloroside-with-an-enhancement-of-antioxidative-effects
#12
Eun-Ju Yang, Ju-Gyeong Lee, Kyung-Sik Song
Herbal medicines were subjected to enzyme reaction by using a commercial glycosidase AMG-300L, and were evaluated for enhancement of their antioxidative activities. The methanolic extract of Gentianae Scabrae Radix (GSR) showed the most dramatic changes after enzyme reaction, as seen in the high-performance liquid chromatography profiles and an increase in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect. Trifloroside (1, TF) was identified as being significantly decreased by enzyme reaction, whereas deglucosyltrifloroside (2, DTF) increased...
September 21, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28933119/-research-on-rat-models-of-acute-liver-injury-with-syndrome-of-liver-depression-and-spleen-deficiency
#13
Na-Na Huang, Xiao-Qian Sun, Qian Yang, Xiao-Yu Li, Rong Sun
This paper aimed to establish animal models which are suitable for the activity found, efficacy evaluation of herbs resistant to acute liver injury with syndrome of liver depression and spleen deficiency and new drug research and development based on corresponding of formula and syndrome. The symptoms that are suitable for evaluating the rat models of acute liver injury with syndrome of liver depression and spleen deficiency were extracted according to the evolution rule of the etiology and pathogenesis in traditional Chinese medicine and the modern pathological mechanism...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28933101/-discussion-on-relevant-theories-of-qi-blood-shen-and-formula-implication-of-guan-xin-jing-capsule
#14
Rui-Ping Li, Guo-Hua Yu, Jun-Fang Li, Shi-Huan Tang
In the field of traditional Chinese medicine(TCM),the definition of "Shen" contains a broad concept and a narrow concept. Broad "Shen" is the dominator and administrator of human vital movement,while narrow "Shen" means spirit, consciousness, thinking and emotions of human. "Shen" originates from innate essence of parents, and survives on acquired essence of water and food as well as the nutrition of its metaplastic Qi-Blood-Body fluid. Qi-Blood,the most precious asset of human body, is a quite important section of one person and the central material basis of "Shen-Zhi"...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28932243/sensitive-wavelengths-selection-in-identification-of-ophiopogon-japonicus-based-on-near-infrared-hyperspectral-imaging-technology
#15
Zhengyan Xia, Chu Zhang, Haiyong Weng, Pengcheng Nie, Yong He
Hyperspectral imaging (HSI) technology has increasingly been applied as an analytical tool in fields of agricultural, food, and Traditional Chinese Medicine over the past few years. The HSI spectrum of a sample is typically achieved by a spectroradiometer at hundreds of wavelengths. In recent years, considerable effort has been made towards identifying wavelengths (variables) that contribute useful information. Wavelengths selection is a critical step in data analysis for Raman, NIRS, or HSI spectroscopy. In this study, the performances of 10 different wavelength selection methods for the discrimination of Ophiopogon japonicus of different origin were compared...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28930879/repeat-effort-performance-is-reduced-24-h-following-acute-dehydration-in-mixed-martial-arts-athletes
#16
Oliver R Barley, Fiona Iredale, Dale W Chapman, Amanda Hopper, Chris Abbiss
This study sought to determine the influence of acute dehydration on physical performance and physiology in Mixed Martial Arts (MMA). MMA athletes (n=14; age: 23±4 years), completed in a randomised counterbalanced order a dehydration protocol, (DHY: 3 h cycling at 60 W in 40°C to induce 5% dehydration) or thermoneutral control (25°C: CONT) exercise, followed by ad libitum fluid/food intake. Performance testing (a repeat sled push test, medicine ball chest throw and vertical jump) was completed 3 and 24 h following the intervention, while urine and blood samples were collected before, 20 min, 3 and 24 h following the intervention...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930277/biological-activities-of-three-essential-oils-of-the-lamiaceae-family
#17
REVIEW
Gema Nieto
Herbs and spices have been used since ancient times to improve the sensory characteristics of food, to act as preservatives and for their nutritional and healthy properties. Herbs and spices are generally recognized as safe (GRAS) and are excellent substitutes for chemical additives. Essential oils are mixtures of volatile compounds obtained, mainly by steam distillation, from medicinal and aromatic plants. They are an alternative to synthetic additives for the food industry, and they have gained attention as potential sources for natural food preservatives due to the growing interest in the development of safe, effective, natural food preservation...
August 23, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930244/characterization-and-antioxidant-activity-of-volatile-constituents-from-different-parts-of-aframomum-danielli-hook-k-schum
#18
Emmanuel E Essien, Paul S Thomas, Kelly Oriakhi, Mohammad I Choudhary
Background:Aframomum danielli is used in ethno-medicine for the treatment of several ailments and as a traditional food spice. Methods: The hydro-distilled leaf, stem, seed, rhizome and pod volatile oils of A. danielli were subjected to gas chromatography-mass spectrometry (GC-MS) analysis. Free radical scavenging capacity of the volatile oils was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Results: Thirty-nine (39) volatile compounds were identified in the oils of A...
May 10, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930239/eryngium-foetidum-l-essential-oils-chemical-composition-and-antioxidant-capacity
#19
Paul S Thomas, Emmanuel E Essien, Samuel J Ntuk, Mohammad I Choudhary
Background:Eryngium foetidum essential oils from Nigeria were investigated for the first time in order to ascertain their potency as natural antioxidants. E. foetidum is an aromatic and medicinal herb used in ethno-medicine and as a traditional spice for foods. Methods: The hydro-distilled oils of E. foetidum were subjected to gas chromatography-mass spectrometry (GC-MS) analysis. Free radical scavenging capacity of the volatile oils was determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays...
April 28, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930224/aromatic-medicinal-plants-of-the-lamiaceae-family-from-uzbekistan-ethnopharmacology-essential-oils-composition-and-biological-activities
#20
REVIEW
Nilufar Z Mamadalieva, Davlat Kh Akramov, Elisa Ovidi, Antonio Tiezzi, Lutfun Nahar, Shahnoz S Azimova, Satyajit D Sarker
Plants of the Lamiaceae family are important ornamental, medicinal, and aromatic plants, many of which produce essential oils that are used in traditional and modern medicine, and in the food, cosmetics, and pharmaceutical industry. Various species of the genera Hyssopus, Leonurus, Mentha, Nepeta, Origanum, Perovskia, Phlomis, Salvia, Scutellaria, and Ziziphora are widespread throughout the world, are the most popular plants in Uzbek traditional remedies, and are often used for the treatment of wounds, gastritis, infections, dermatitis, bronchitis, and inflammation...
February 10, 2017: Medicines (Basel, Switzerland)
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