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Multiple sclerosis cognition

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https://www.readbyqxmd.com/read/29438835/structural-mri-correlates-of-cognitive-function-in-multiple-sclerosis
#1
Artemios Artemiadis, Maria Anagnostouli, Ioannis Zalonis, Konstantinos Chairopoulos, Nikos Triantafyllou
BACKGROUND: Cognitive impairment (CI) has been associated with numerous magnetic resonance imaging (MRI) indices in multiple sclerosis (MS) patients. In this study we investigated the association of a large set of 2D and 3D MRI markers with cognitive function in MS. METHODS: A sample of 61 RRMS patients (mean age 41.8 ± 10.6 years old, 44 women, mean disease duration 137.9 ± 83.9 months) along with 51 age and gender matched healthy controls was used in this cross-sectional study...
February 6, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29426814/exploring-the-specific-needs-of-persons-with-multiple-sclerosis-for-mhealth-solutions-for-physical-activity-mixed-methods-study
#2
Guido Giunti, Jan Kool, Octavio Rivera Romero, Enrique Dorronzoro Zubiete
BACKGROUND: Multiple sclerosis (MS) is one of the world's most common neurologic disorders, with symptoms such as fatigue, cognitive problems, and issues with mobility. Evidence suggests that physical activity (PA) helps people with MS reduce fatigue and improve quality of life. The use of mobile technologies for health has grown in recent years with little involvement from relevant stakeholders. User-centered design (UCD) is a design philosophy with the goal of creating solutions specific to the needs and tasks of the intended users...
February 9, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29424049/astrocyte-disruption-of-neurovascular-communication-is-linked-to-cortical-damage-in-an-animal-model-of-multiple-sclerosis
#3
Raya Eilam, Menahem Segal, Rafael Malach, Michael Sela, Ruth Arnon, Rina Aharoni
To elucidate mechanisms contributing to cortical pathology in multiple sclerosis (MS), we investigated neurovascular aberrations, in particular the association of astrocytes with cortical neurons and blood vessels, in mice induced with experimental autoimmune encephalomyelitis (EAE). Blood-brain barrier (BBB) dysfunction was evident by leakage of the tracer sodium fluorescein, along with reduced expression of claudin-5 by endothelial cells and desmin by pericytes. Immunohistological and ultrastructural analyses revealed detachment of the astroglial cell bodies from the blood vessels and loss of their connections with both the blood vessels and the neuronal synapses...
February 9, 2018: Glia
https://www.readbyqxmd.com/read/29417493/depression-in-multiple-sclerosis-epidemiology-aetiology-diagnosis-and-treatment
#4
REVIEW
Claudio Solaro, Giulia Gamberini, Fabio Giuseppe Masuccio
Depressive disorders are common in patients with multiple sclerosis, influencing their quality of life and adherence to treatments, as well as becoming more frequent with the progression of the disease and in the secondary progressive form of multiple sclerosis. Patients with multiple sclerosis often experience a typical cluster of symptoms in association with depression, such as fatigue, pain and cognitive impairment. However, the pathogenesis of multiple sclerosis-related depression remains partially unclear, even though genetic, immune-inflammatory and psychosocial factors might be seen to play a role, in addition to the brain structural alterations documented by magnetic resonance imaging studies...
February 7, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29414299/predicting-falls-in-multiple-sclerosis-do-electrophysiological-measures-have-a-better-predictive-accuracy-compared-to-clinical-measures
#5
Somasundaram Aadhimoolam Chinnadurai, Divya Gandhirajan, Avathvadi Venkatesan Srinivasan, Bhanu Kesavamurthy, Lakshmi Narasimhan Ranganathan, Vijaya Pamidimukkala
BACKGROUND: The risk of falls in people with Multiple Sclerosis (MS) is much greater than that of the general population due to impaired coordination, gait, sensation, muscle tone, strength, and cognition. These MS related falls hamper the day to day living of these individuals and are one of the prime factors aggravating the disease related morbidity. The fear of falling itself may make these individuals more dependent and hinder their professional and leisurely activities. Hence, the significance of identifying individuals who are at risk of falling and instituting preventive counter-measures cannot be overemphasized...
February 2, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29414290/correlation-between-the-corpus-callosum-index-and-brain-atrophy-lesion-load-and-cognitive-dysfunction-in-multiple-sclerosis
#6
Lucas Immich Gonçalves, Giordani Rodrigues Dos Passos, Lucas Piccoli Conzatti, Jorge Luiz Palmeiro Burger, Gustavo Henrique Tomasi, Manuella Édler Zandoná, Luciana Schermann Azambuja, Irênio Gomes, Alexandre Franco, Douglas Kazutoshi Sato, Jefferson Becker
BACKGROUND: The corpus callosum index (CCI) can be easily and reliably obtained from conventional magnetic resonance imaging (MRI) and has been proposed as a possible marker of brain atrophy in MS. However, further validation of its correlation with volumetric measurements is still warranted. OBJECTIVE: To assess the correlation of the CCI with the corpus callosum volume (CCV), brain and lesion volumes, and level of disability in MS. METHODS: Cross-sectional, exploratory study including patients with relapsing-remitting MS...
January 26, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29414287/symbol-digit-modalities-test-adaptation-for-magnetic-resonance-imaging-environment-a-systematic-review-and-meta-analysis
#7
REVIEW
P H R Silva, C T Spedo, A A Barreira, R F Leoni
BACKGROUND: The Symbol Digit Modalities Test (SDMT) is widely used for cognitive evaluation of information processing speed (IPS), required in many cognitive operations. Despite being unspecific for different neurological disorders, it is sensitive to assess impaired performance related to stroke, Parkinson's disease, traumatic brain injury, and multiple sclerosis. However, in addition to evaluate the presence and severity of IPS impairment, it is of interest to determine the localization and integration of brain regions responsible for the functions assessed by the SDMT...
January 25, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29414284/relationship-between-social-cognition-and-traditional-cognitive-impairment-in-progressive-multiple-sclerosis-and-possible-implicated-neuroanatomical-regions
#8
E Ciampi, R Uribe-San-Martin, M Vásquez, A Ruiz-Tagle, T Labbe, J P Cruz, P Lillo, A Slachevsky, D Reyes, A Reyes, C Cárcamo-Rodríguez
BACKGROUND: Cognitive impairment is a relevant contributor of the medical and social burden in Progressive MS. Social Cognition, the neurocognitive processes underlying social interaction, has been explored mainly in European and North American cohorts, influencing social aspects of quality of life (QOL) of early MS patients and families. Few studies have studied Social Cognition in Progressive MS and the literature on its neuroanatomical bases or brain atrophy measurements is still scarce...
January 25, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29411360/efficacy-of-group-cognitive-rehabilitation-therapy-in-multiple-sclerosis
#9
A Mani, E Chohedri, P Ravanfar, A Mowla, A Nikseresht
OBJECTIVE: Cognitive impairment occurs in 40%-65% of patients with multiple sclerosis (MS). Several techniques for cognitive rehabilitation (CR) in these patients have been evaluated; however, the results have been controversial. In this study, we investigated the efficacy of group compensatory CR in patients with MS-related cognitive impairment. MATERIALS AND METHODS: Thirty-four female patients with diagnosed relapsing-remitting MS and evidence of impaired cognitive function were included and randomized to intervention (n = 17) and control (n = 17) groups...
February 7, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29406960/cognition-in-multiple-sclerosis-between-cognitive-reserve-and-brain-volume
#10
G Fenu, L Lorefice, M Arru, V Sechi, L Loi, F Contu, F Cabras, G Coghe, J Frau, M Fronza, G Sbrescia, V Lai, M Boi, S Mallus, S Murru, A Porcu, M A Barracciu, M G Marrosu, E Cocco
BACKGROUND: Several correlations between cognitive impairment (CI), radiologic markers and cognitive reserve (CR) have been documented in MS. OBIECTIVE: To evaluate correlation between CI and brain volume (BV) considering CR as possibile mitigating factor. METHODS: 195 relapsing MS patients underwent a neuropsychological assessment using BICAMS. BV was estimated using SIENAX to obtain normalized volume of brain (NBV), white matter (NWV), gray matter (NGV) and cortical gray matter (CGV)...
March 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29406911/anti-cholinergic-medications-for-bladder-dysfunction-worsen-cognition-in-persons-with-multiple-sclerosis
#11
Sarah A Morrow, Heather Rosehart, Alp Sener, Blayne Welk
Bladder dysfunction is common in persons with MS (PwMS), often due to detrusor muscle overactivity. Anticholinergic medications are considered the first line treatment for bladder dysfunction and are known to worsen cognition in healthy older adults and in persons with dementia. Yet, it is not known if these medications have the same effect on PwMS. Thus, the Objective of this prospective matched-cohort study was to determine if anticholinergic medications affect objective measures of cognition in PwMS. We recruited PwMS starting either oxybutynin or tolterodine (cases)...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29406017/examining-the-effectiveness-of-acetylcholinesterase-inhibitors-and-stimulant-based-medications-for-cognitive-dysfunction-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#12
REVIEW
Jack Cotter, Nils Muhlert, Anahita Talwar, Kiri Granger
We sought to examine the effectiveness of acetylcholinesterase inhibitors (AChEIs) and stimulant-based medications for improving cognitive performance in patients with multiple sclerosis (MS). An electronic database search was conducted on 25th March 2017. Eligible studies were double-blind, randomised, placebo-controlled trials that examined the efficacy of compounds that act primarily as AChEIs or stimulants (administered daily for ≥1 week) on cognitive outcome measures in patients with MS. Where suitable data was reported, we generated effect sizes and corresponding 95% confidence intervals and performed meta-analyses using random-effects models to investigate the effectiveness of these drug types across cognitive domains...
March 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29403649/a-protocol-for-a-randomised-double-blind-placebo-controlled-feasibility-study-to-determine-whether-the-daily-consumption-of-flavonoid-rich-pure-cocoa-has-the-potential-to-reduce-fatigue-in-people-with-relapsing-and-remitting-multiple-sclerosis-rrms
#13
S Coe, J Collett, H Izadi, D T Wade, M Clegg, J M Harrison, E Buckingham, A Cavey, G C DeLuca, J Palace, H Dawes
Background: Dietary interventions including consumption of flavonoids, plant compounds found in certain foods, may have the ability to improve fatigue. However, to date, no well-designed intervention studies assessing the role of flavonoid consumption for fatigue management in people with MS (pwMS) have been performed. The hypothesis is that the consumption of a flavonoid-rich pure cocoa beverage will reduce fatigue in pwMS. The aim of this study is to determine the feasibility and potential outcome of running a trial to evaluate this hypothesis...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29403354/hypothalamic-alterations-in-neurodegenerative-diseases-and-their-relation-to-abnormal-energy-metabolism
#14
REVIEW
Pauline Vercruysse, Didier Vieau, David Blum, Åsa Petersén, Luc Dupuis
Neurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington's disease (HD), or cognitive in Alzheimer's disease (AD) and fronto-temporal dementia (FTD). Besides the common existence of neuronal loss, NDDs are also associated with metabolic changes such as weight gain, weight loss, loss of fat mass, as well as with altered feeding behavior...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29400912/classic-block-design-pseudo-resting-state-fmri-changes-after-a-neurorehabilitation-program-in-patients-with-multiple-sclerosis
#15
Deborah Pareto, Jaume Sastre-Garriga, Juli Alonso, Ingrid Galán, Maria Jesus Arévalo, Marta Renom, Xavier Montalban, Àlex Rovira
BACKGROUND AND PURPOSE: The goal of this study was to assess changes in the resting-state networks (RSNs) of patients with multiple sclerosis (MS) after a cognitive rehabilitation program (CRP), by retrospectively analyzing functional magnetic resonance imaging (fMRI) studies using the classical block design. METHODS: Fifteen patients with MS (2 primary progressive, 3 relapsing-remitting, 10 secondary progressive) were scanned before and after the CRP on a 1.5T MRI scanner...
February 5, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29396679/cerebellum-and-cognition-in-multiple-sclerosis-the-fall-status-matters
#16
Alon Kalron, Gilles Allali, Anat Achiron
Cerebellar volume has been linked with cognitive performances in MS; however, the association in terms of fall status has never been compared. Therefore, the objective of the current study was to compare cognitive performance with cerebellar volume between MS fallers and non-fallers. The cross-sectional study included 140 PwMS (96 women). MRI volumetric analysis was based on the FreeSurfer image analysis suite. Volumes of the cerebellar gray and white matter were identified as the region of interest. Cognitive function included scores obtained from a computerized cognitive battery of tests...
February 2, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29384421/relation-of-serum-levels-of-homocysteine-vitamin-b12-and-folate-to-cognitive-functions-in-multiple-sclerosis-patients
#17
Ebtesam Mohamed Fahmy, Nervana Mohamed Elfayoumy, Ahmed Mohamed Abdelalim, Sahar Abdel-Aaty Sharaf, Rania Shehata Ismail, Haidy Elshebawy
BACKGROUND: Hyperhomocysteinemia, vitamin B12 and folate deficiency have been linked to cognitive dysfunction in multiple sclerosis (MS) patients. OBJECTIVE: This study aimed to investigate the relation of serum homocysteine (Hcy), vitamin B12 and folate to cognitive functions in MS patients. SUBJECTS AND METHODS: Forty-five MS patients and twenty matched healthy controls were included. Subjects were submitted to cognitive assessment using a selected psychometric battery and measurement of serum levels of homocysteine, B12 and folic acid...
January 31, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29382353/laquinimod-attenuates-inflammation-by-modulating-macrophage-functions-in-traumatic-brain-injury-mouse-model
#18
Atsuko Katsumoto, Aline S Miranda, Oleg Butovsky, Antônio L Teixeira, Richard M Ransohoff, Bruce T Lamb
BACKGROUND: Traumatic brain injury (TBI) is a critical public health and socio-economic problem worldwide. A growing body of evidence supports the involvement of inflammatory events in TBI. It has been reported that resident microglia and infiltrating monocytes promote an inflammatory reaction that leads to neuronal death and eventually behavioral and cognitive impairment. Currently, there is no effective treatment for TBI and the development of new therapeutic strategies is a scientific goal of highest priority...
January 30, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29381774/correction-cognitive-function-in-multiple-sclerosis-improves-with-telerehabilitation-results-from-a-randomized-controlled-trial
#19
Leigh E Charvet, Jie Yang, Michael T Shaw, Kathleen Sherman, Lamia Haider, Jianjin Xu, Lauren B Krupp
[This corrects the article DOI: 10.1371/journal.pone.0177177.].
2018: PloS One
https://www.readbyqxmd.com/read/29380545/diffusion-kurtosis-imaging-shows-similar-cerebral-axonal-damage-in-patients-with-hiv-infection-and-multiple-sclerosis
#20
Korhan Buyukturkoglu, Lazar Fleyser, Desiree Byrd, Susan Morgello, Matilde Inglese
BACKGROUND AND PURPOSE: In this pilot study, we sought to investigate the pathological changes in the white matter (WM) of medically complex, combination antiretroviral therapy (cART)-treated patients with human immunodeficiency virus (HIV), comparing them to patients with long-standing, secondary progressive multiple sclerosis (SPMS). METHODS: Using diffusion kurtosis imaging (DKI)-derived WM tract integrity (WMTI) metrics, 15 HIV and 15 age- and sex-matched SPMS patients with similar disease duration underwent magnetic resonance imaging analysis...
January 30, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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