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Multiple sclerosis cognition

Andrew D Smith, Charles Duffy, Andrew D Goodman
Background: Although cognitive dysfunction is a leading cause of disability and poor quality of life in patients with multiple sclerosis (MS), it is infrequently tested in routine clinical evaluation. Development of a cognitive testing paradigm that captured MS-related cognitive dysfunction and could be obtained in a routine clinical setting may increase surveillance and recognition of cognitive dysfunction. Objectives: This was a pilot study to determine if Cognivue could find cognitive performance differences between patients with MS and healthy controls (HC)...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
M León Ruiz, M Sospedra, S Arce Arce, J Tejeiro-Martínez, J Benito-León
INTRODUCTION: A growing number of studies have evaluated the effects of transcranial magnetic stimulation (TMS) for the symptomatic treatment of multiple sclerosis (MS). METHODS: We performed a PubMed search for articles, recent books, and recommendations from the most relevant clinical practice guidelines and scientific societies regarding the use of TMS as symptomatic treatment in MS. CONCLUSIONS: Excitatory electromagnetic pulses applied to the affected cerebral hemisphere allow us to optimise functional brain activity, including the transmission of nerve impulses through the demyelinated corticospinal pathway...
June 10, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Ting Shen, Yuyi You, Chitra Joseph, Mehdi Mirzaei, Alexander Klistorner, Stuart L Graham, Vivek Gupta
Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous system. A common single-nucleotide polymorphism in the pro-region of the human BDNF gene, resulting in a valine to methionine substitution (Val66Met), has been associated with the susceptibility, incidence, and clinical features of several neurodegenerative disorders. Much research has been dedicated to evaluating the effects of polymorphism in the past decade, and functional effects of this genetic variation...
June 2018: Aging and Disease
Kaitlynne Leclaire, Audrey Cecil, Allison LaRussa, Fiona Stuart, Christopher C Hemond, Brian C Healy, Tanuja Chitnis, Howard Weiner, Jeff Huffman, Bonnie I Glanz
Background: Positive psychology uses targeted activities to increase the frequency and intensity of positive emotional experiences. Positive psychology interventions that increase positive constructs may facilitate adjustment and improve well-being in patients with multiple sclerosis (MS). The primary goal of this study was to assess the feasibility and acceptability of a 5-week group positive psychology intervention for patients with MS. In addition, we examined the utility of the group intervention to increase positive psychological constructs and health-related quality of life (HRQOL)...
May 2018: International Journal of MS Care
Marcin Kacper Uszynski, Blathin Casey, Sara Hayes, Stephen Gallagher, Helen Purtill, Robert W Motl, Susan Coote
Background: There is a growing body of evidence that physical activity (PA) improves symptoms of multiple sclerosis (MS). Despite the benefits of PA, people with MS are relatively inactive compared with their healthy counterparts. This study investigated associations between social cognitive theory (SCT) constructs and energy expenditure (EE) as an objective measure of PA in a sample of inactive people with MS. Methods: Participants (n = 65) completed several questionnaires and were assessed using standardized outcome measures as part of a cross-sectional analysis of baseline data from a randomized controlled trial (Step it Up)...
May 2018: International Journal of MS Care
Ryo Ohtomo, Atsushi Iwata, Ken Arai
Even in adult brains, restorative mechanisms are still retained to maintain the microenvironment. Under the pathological conditions of central nervous system (CNS) diseases, several immature cells in the brain would be activated as a compensative response. As the concept of the neurovascular unit emphasizes, cell-cell interactions play important roles in this restorative process. White matter damage and oligodendrocyte loss are representative characteristics for many neurodegenerative diseases. In response to oligodendrocyte damage, residual oligodendrocyte precursor cells (OPCs) initiate their proliferation and differentiation for the purpose of remyelination...
June 12, 2018: International Journal of Molecular Sciences
Marta Waliszewska-Prosół, Marta Nowakowska-Kotas, Roman Kotas, Tomasz Bańkowski, Anna Pokryszko-Dragan, Ryszard Podemski
BACKGROUND: The clinical course of multiple sclerosis (MS) can vary significantly among patients and is affected by exogenous and endogenous factors. Among these, stress and personality type have been gaining more attention. OBJECTIVES: The aim of this study was to investigate the parameters of event-related potentials (ERPs) with regards to stress perception and personality type, as well as cognitive performance in MS patients. MATERIAL AND METHODS: The study group consisted of 30 MS patients and 26 healthy controls...
June 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Zafer Keser, Arash Kamali, Kyan Younes, Paul E Schulz, Flavia M Nelson, Khader M Hasan
BACKGROUND AND PURPOSE: In 1948, Paul Yakovlev described an additional limbic circuit located basolateral to James Papez's circuit (1937) and included orbitofrontal cortex, amygdala, and dorsomedial nucleus of thalamus. This circuit is shown to be an important component of subcortical cognitive abilities. We aimed to demonstrate this circuit in a multiple sclerosis (MS) cohort using diffusion tensor imaging (DTI) and evaluate its role in MS-related cognitive impairment (CI). METHODS: We enrolled cognitively intact (n = 10) and impaired (n = 36) MS patients who underwent a comprehensive cognitive assessment; the minimal assessment of cognitive function in MS (MACFIMS) and structural magnetic resonance imaging...
June 12, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Anne M Skalicky, Anne M Rentz, Zhimei Liu, Qayyim Said, Jo Anne Nakagawa, Michael D Frost, James W Wheless, David W Dunn
AIMS: Tuberous sclerosis complex (TSC) is a multi-organ autosomal-dominant, genetic disorder with incomplete penetrance. The multiple manifestations of TSC and impacts to numerous organ systems represent significant disease, health care and treatment burden. The economic and employment burden of the disease on individuals and their families is poorly understood. This study assessed the cost of illness and work and school productivity burden associated with TSC in a cross-sectional web-survey sample...
June 11, 2018: Journal of Medical Economics
Alexandra Tremblay, Céline Jobin, Mélanie Demers, Emmanuelle Dagenais, Sridar Narayanan, David Araújo, Arnold L Douglas, Elaine Roger, Laury Chamelian, Pierre Duquette, Isabelle Rouleau
OBJECTIVES: Although multiple sclerosis (MS) has long been considered to primarily affect white matter, it is now recognized that cognitive deficits in MS are also related to neocortical, thalamic and hippocampal damage. However, the association between damage to these structures and memory deficits in MS is unclear. This study examines whether MS patients with cognitive impairment have a reduction of hippocampal and/or thalamic volumes compared to cognitively intact patients, and whether these volume reductions correlate with various aspects of memory function...
June 8, 2018: Brain and Cognition
Marta Simone, Rosa Gemma Viterbo, Lucia Margari, Pietro Iaffaldano
BACKGROUND: The treatment of cognitive deficits is challenging in pediatric onset multiple sclerosis (POMS) and in patients with attention deficit hyperactivity disorder (ADHD). We performed a pilot double-blind RCT to evaluate the efficacy of a home-based computerized-program for retraining attention in two cohorts of POMS and ADHD patients. METHODS: POMS and ADHD patients failing in at least 2/4 attention tests on a neuropsychological battery were randomized to specific or nonspecific computerized training (ST, nST), performed in one-hour sessions, twice/week for 3 months...
June 8, 2018: BMC Neurology
Somasundaram Aadhimoolam Chinnadurai, Divya Gandhirajan, Vijaya Pamidimukala, Bhanu Kesavamurthy, Srinivasan Avathvadi Venkatesan
OBJECTIVES: We aimed to determine whether there was a relationship between objective measures of sleep measured by polysomnography and measures of physical and cognitive fatigue in patients with Multiple Sclerosis (MS). METHODS: People with MS of age 18-50 years of any subtype attending the OPD satisfying the revised 2010 McDonald criteria were recruited. Modified Fatigue Impact Scale (MFIS) and the Fatigue Severity Scale (FSS) were used to assess physical fatigue...
May 23, 2018: Multiple Sclerosis and related Disorders
Murray W Enns, Charles N Bernstein, Kristine Kroeker, Lesley Graff, John R Walker, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, John D Fisk, Ruth Ann Marrie
Impairment in work function is a frequent outcome in patients with chronic conditions such as immune-mediated inflammatory diseases (IMID), depression and anxiety disorders. The personal and economic costs of work impairment in these disorders are immense. Symptoms of pain, fatigue, depression and anxiety are potentially remediable forms of distress that may contribute to work impairment in chronic health conditions such as IMID. The present study evaluated the association between pain [Medical Outcomes Study Pain Effects Scale], fatigue [Daily Fatigue Impact Scale], depression and anxiety [Hospital Anxiety and Depression Scale] and work impairment [Work Productivity and Activity Impairment Scale] in four patient populations: multiple sclerosis (n = 255), inflammatory bowel disease (n = 248, rheumatoid arthritis (n = 154) and a depression and anxiety group (n = 307), using quantile regression, controlling for the effects of sociodemographic factors, physical disability, and cognitive deficits...
2018: PloS One
Bailee L Malivoire, Crystal J Hare, Tae L Hart
PURPOSE/OBJECTIVE: Perceived cognitive impairment is a common concern among individuals with multiple sclerosis (MS) and is associated with prevalent psychological symptoms, namely depression and anxiety. The mechanisms by which these psychological symptoms are associated with perceived cognitive impairment among people diagnosed with MS have been unexplored. A possible mechanism is rumination, a maladaptive form of self-reflection that is commonly associated with anxiety and depression...
May 2018: Rehabilitation Psychology
Yael Goverover, John DeLuca
BACKGROUND: Multiple sclerosis (MS) can have dramatic effects on performance of everyday life activity. However, the ability to assess everyday functional activity remains elusive. The purpose of this study was to establish validity and reliability to a performance-based assessment of everyday life activities called actual reality (AR). AR involves utilization of the Internet to perform three actual everyday life activities: purchasing (a) an airline ticket, (b) cookies, and (c) pizza...
May 2018: Rehabilitation Psychology
Barbara Willekens, Gaetano Perrotta, Patrick Cras, Nathalie Cools
Mindfulness was introduced in the Western world by Jon Kabat-Zinn in 1979. He defined it as "awareness that arises through paying attention, on purpose, in the present moment, non-judgmentally." Since then, research on mindfulness-based interventions (MBIs) has increased exponentially both in health and disease, including in patients with neurodegenerative diseases such as dementia and Parkinson's disease. Research on the effect of mindfulness and multiple sclerosis (MS) only recently gained interest...
2018: Frontiers in Behavioral Neuroscience
Tamás Biernacki, Krisztina Bencsik, Dániel Sandi, László Vécsei
Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system comprising of inflammation, demyelinisation and neurodegeneration. The natural history of MS is heterogenous. Owing to the vast range and severity of the symptoms MS can cause the effect of the disease on one's cognitive and physical status is unpredictable. According to the new, phenotype based classification two subgroups can be distinguished; relapsing-remitting (RR) and progressive MS. Relapsing-remitting MS can be further divided into active and inactive disease...
November 30, 2017: Ideggyógyászati Szemle
Juan I Rojas, Georgina Murphy, Francisco Sanchez, Liliana Patrucco, Maria C Fernandez, Jimena Miguez, Jorge Funes, Angel Golimstok, Edgardo Cristiano
Aims The objective of the study was to assess whether changes in the volume of the thalamus during the onset of multiple sclerosis predict cognitive impairment after accounting for the effects of brain volume loss. Methods A prospective study included patients with relapsing-remitting multiple sclerosis less than 3 years after disease onset (defined as the first demyelinating symptom), Expanded Disability Status Scale of 3 or less, no history of cognitive impairment and at least 2 years of follow-up. Patients were clinically followed up with annual brain magnetic resonance imaging and neuropsychological evaluations for 2 years...
January 1, 2018: Neuroradiology Journal
Jack Cotter, Nethmi Vithanage, Shuna Colville, Dawn Lyle, Denise Cranley, Francesca Cormack, Jennifer H Barnett, Katy Murray, Suvankar Pal
Cognitive dysfunction is present in up to 70% of patients with multiple sclerosis (MS) and has been reported at all stages and in all subtypes of the disease. These deficits have been reported across a variety of cognitive domains, but are generally under-recognized and incompletely evaluated in routine clinical practice. The aim of this study was to investigate the spectrum of cognitive impairment in patients with MS presenting to a specialist MS clinic using the Cambridge Neuropsychological Test Automated Battery (CANTAB), administered on a touchscreen platform...
2018: Frontiers in Neurology
Dena Sadeghi Bahmani, Leila Esmaeili, Vahid Shaygannejad, Markus Gerber, Juerg Kesselring, Undine E Lang, Edith Holsboer-Trachsler, Serge Brand
Background: Previous research of patients with multiple sclerosis (MS) focused prevalently on fatigue, depression, and cognitive dysfunction during the clinical course. By contrast, research on the longer-term characteristics of physical activity (PA), psychological functioning, and sleep problems is scarce. The aims of the present study were therefore to examine changes in PA, mental toughness (MT) as a proxy of psychological functioning, and sleep disturbances over a 2-year period of time after disease onset...
2018: Frontiers in Psychiatry
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