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Multiple sclerosis cognition

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https://www.readbyqxmd.com/read/29234305/functional-components-of-cognitive-impairment-in-multiple-sclerosis-a-cross-sectional-investigation
#1
Jordi A Matias-Guiu, Ana Cortés-Martínez, María Valles-Salgado, Celia Oreja-Guevara, Vanesa Pytel, Paloma Montero, Teresa Moreno-Ramos, Jorge Matias-Guiu
Background: Cognitive impairment is frequent and disabling in multiple sclerosis (MS). Changes in information processing speed constitute the most important cognitive deficit in MS. However, given the clinical and topographical variability of the disease, cognitive impairment may vary greatly and appear in other forms in addition to slower information processing speed. Our aim was to determine the frequency of cognitive impairment, the principal cognitive domains, and components involved in MS and to identify factors associated with presence of cognitive impairment in these patients in a large series of patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29224261/-current-situation-and-prospect-of-diagnosis-and-treatment-of-tuberous-sclerosis-related-renal-angiomyolipoma
#2
H Z Li, Y S Zhang
Tuberous sclerosis complex is an autosomal dominant disease involving multiple organs and multiple systems. The main manifestation is renal angiomyolipoma in the kidney. It is the most common cause of death in adults, because of its high incidence, rapid growth and bleeding. The incidence of this disease is low and the cognition is not enough, so the diagnosis and treatment are lack of standardization. Recently, the expert consensus of the diagnosis and treatment of tuberous sclerosis related renal angiomyolipoma has been established in China...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29223871/intensity-ratio-to-improve-black-hole-assessment-in-multiple-sclerosis
#3
Gautam Adusumilli, Kathryn Trinkaus, Peng Sun, Samantha Lancia, Jeffrey D Viox, Jie Wen, Robert T Naismith, Anne H Cross
BACKGROUND: Improved imaging methods are critical to assess neurodegeneration and remyelination in multiple sclerosis. Chronic hypointensities observed on T1-weighted brain MRI, "persistent black holes," reflect severe focal tissue damage. Present measures consist of determining persistent black holes numbers and volumes, but do not quantitate severity of individual lesions. OBJECTIVE: Develop a method to differentiate black and gray holes and estimate the severity of individual multiple sclerosis lesions using standard magnetic resonance imaging...
December 2, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29220677/a-powerful-approach-to-estimating-annotation-stratified-genetic-covariance-via-gwas-summary-statistics
#4
Qiongshi Lu, Boyang Li, Derek Ou, Margret Erlendsdottir, Ryan L Powles, Tony Jiang, Yiming Hu, David Chang, Chentian Jin, Wei Dai, Qidu He, Zefeng Liu, Shubhabrata Mukherjee, Paul K Crane, Hongyu Zhao
Despite the success of large-scale genome-wide association studies (GWASs) on complex traits, our understanding of their genetic architecture is far from complete. Jointly modeling multiple traits' genetic profiles has provided insights into the shared genetic basis of many complex traits. However, large-scale inference sets a high bar for both statistical power and biological interpretability. Here we introduce a principled framework to estimate annotation-stratified genetic covariance between traits using GWAS summary statistics...
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29212827/diet-quality-is-associated-with-disability-and-symptom-severity-in-multiple-sclerosis
#5
Kathryn C Fitzgerald, Tuula Tyry, Amber Salter, Stacey S Cofield, Gary Cutter, Robert Fox, Ruth Ann Marrie
OBJECTIVE: To assess the association between diet quality and intake of specific foods with disability and symptom severity in people with multiple sclerosis (MS). METHODS: In 2015, participants in the North American Research Committee on MS (NARCOMS) Registry completed a dietary screener questionnaire that estimates intake of fruits, vegetables and legumes, whole grains, added sugars, and red/processed meats. We constructed an overall diet quality score for each individual based on these food groups; higher scores denoted a healthier diet...
December 6, 2017: Neurology
https://www.readbyqxmd.com/read/29209169/amyloid-%C3%AE-homeostasis-bridges-inflammation-synaptic-plasticity-deficits-and-cognitive-dysfunction-in-multiple-sclerosis
#6
Mario Stampanoni Bassi, Sara Garofalo, Girolama A Marfia, Luana Gilio, Ilaria Simonelli, Annamaria Finardi, Roberto Furlan, Giulia M Sancesario, Jonny Di Giandomenico, Marianna Storto, Francesco Mori, Diego Centonze, Ennio Iezzi
Cognitive deficits are frequently observed in multiple sclerosis (MS), mainly involving processing speed and episodic memory. Both demyelination and gray matter atrophy can contribute to cognitive deficits in MS. In recent years, neuroinflammation is emerging as a new factor influencing clinical course in MS. Inflammatory cytokines induce synaptic dysfunction in MS. Synaptic plasticity occurring within hippocampal structures is considered as one of the basic physiological mechanisms of learning and memory. In experimental models of MS, hippocampal plasticity is profoundly altered by proinflammatory cytokines...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29207954/the-turkish-validation-of-the-brief-international-cognitive-assessment-for-multiple-sclerosis-bicams-battery
#7
Serkan Ozakbas, Pinar Yigit, Bilge Piri Cinar, Hatice Limoncu, Turhan Kahraman, Görkem Kösehasanoğulları
BACKGROUND: Cognitive impairment may be seen in as many as 43-70% of patients with multiple sclerosis (MS) and may be observed in all MS subtypes. The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS) battery may be used to evaluate cognition status. The purpose of the current study is to validate the BICAMS battery in Turkish. METHODS: Patients with MS attending our clinic between September 2014 and April 2015 were invited to participate. Healthy control participants were matched in terms of age, gender and years of education...
December 6, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29200085/physical-and-cognitive-functions-physical-activity-and-sedentary-behavior-in-older-adults-with-multiple-sclerosis
#8
Rachel E Bollaert, Robert W Motl
BACKGROUND AND PURPOSE: Older adults with multiple sclerosis (MS) experience age-related declines in physical and cognitive functions that may be compounded by the disease and its progression and worsened by physical inactivity and sedentary behavior. However, the extent to which impairments in physical and cognitive functions are manifestations of MS and disease progression, reflective of the general aging process, or perhaps 2 detrimental processes exacerbating the synergistic effects of the other is relatively unknown...
December 1, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29198279/neuropsychology-of-multiple-sclerosis-looking-back-and-moving-forward
#9
Ralph H B Benedict, John DeLuca, Christian Enzinger, Jeroen J G Geurts, Lauren B Krupp, Stephen M Rao
The neuropsychological aspects of multiple sclerosis (MS) have evolved over the past three decades. What was once thought to be a rare occurrence, cognitive dysfunction is now viewed as one of the most disabling symptoms of the disease, with devastating effects on patients' quality of life. This selective review will highlight major innovations and scientific discoveries in the areas of neuropathology, neuroimaging, diagnosis, and treatment that pertain to our understanding of the neuropsychological aspects of MS...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29194293/multiple-pathological-mechanisms-contribute-to-hippocampal-damage-in-the-experimental-autoimmune-encephalomyelitis-model-of-multiple-sclerosis
#10
Elizabeth L Kyran, Christine Robinson, Pece Kocovski, Zhenjiang Li, Phuc T Dang, Matthew W Hale, Jacqueline M Orian
Emotional and cognitive deficits and associated hippocampal damage observed in multiple sclerosis (MS) are now recognized as primary disease manifestations. However, the pathological substrate of these dysfunctions is unclear. In the experimental autoimmune encephalomyelitis (EAE) MS model, impaired hippocampal-dependent functions are concomitant with severe microglial reactivity and neurodegeneration, but reports vary with respect to evidence of lymphocytic infiltration, raising questions as to the nature of the underlying neurodegenerative mechanisms...
January 3, 2018: Neuroreport
https://www.readbyqxmd.com/read/29184534/pronounced-structural-and-functional-damage-in-early-adult-pediatric-onset-multiple-sclerosis-with-no-or-minimal-clinical-disability
#11
Antonio Giorgio, Jian Zhang, Maria Laura Stromillo, Francesca Rossi, Marco Battaglini, Lucia Nichelli, Marzia Mortilla, Emilio Portaccio, Bahia Hakiki, Maria Pia Amato, Nicola De Stefano
Pediatric-onset multiple sclerosis (POMS) may represent a model of vulnerability to damage occurring during a period of active maturation of the human brain. Whereas adaptive mechanisms seem to take place in the POMS brain in the short-medium term, natural history studies have shown that these patients reach irreversible disability, despite slower progression, at a significantly younger age than adult-onset MS (AOMS) patients. We tested for the first time whether significant brain alterations already occurred in POMS patients in their early adulthood and with no or minimal disability (n = 15) in comparison with age- and disability-matched AOMS patients (n = 14) and to normal controls (NC, n = 20)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29177070/evaluation-of-neurological-changes-in-secondary-progressive-multiple-sclerosis-patients-treated-with-immune-modulator-mis416-results-from-a-feasibility-study
#12
Gill A Webster, Dalice A Sim, Anne C La Flamme, Nancy E Mayo
Background: While disease progression can be readily monitored in early stage relapsing multiple sclerosis (MS), it is more challenging for secondary progressive multiple sclerosis (SPMS). This advanced stage of disease has distinct pathophysiology due to compartmentalization of neuroinflammatory activity within the central nervous system, resulting in increased incidence and severity of cognitive dysfunction. The shift in the dominant disease pathways is underscored by the failure of relapsing therapies to benefit SPMS patients, highlighting the need for novel treatment strategies and clinical trial endpoints that are well-aligned with potential benefits...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29167049/does-the-presence-of-multiple-sclerosis-impact-on-symptom-profile-in-depressed-patients
#13
Rosa E Boeschoten, Roxanne Schaakxs, Joost Dekker, Bernard M J Uitdehaag, Aartjan T F Beekman, Johannes H Smit, Brenda W J H Penninx, Patricia van Oppen
OBJECTIVE: Major depressive disorder (MDD) is common in patients with multiple sclerosis (MS) but may remain unrecognized because of overlapping symptoms and different presentation due to its specific MS-related neurobiological aetiology. We aimed to investigate the clinical profile of MDD in MS. METHODS: In a sample of MDD patients with MS (n=83) and without MS (n=782), MDD characteristics, 30 depressive symptoms, and sum scores of cognitive, somatic, atypical and melancholic symptom clusters were compared using logistic regression analyses and analysis of co-variance...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29166690/-facial-emotion-recognition-theory-of-mind-and-empathy-in-multiple-sclerosis
#14
Samar S Ayache, Moussa A Chalah, Tania Kuempfel, Frank Padberg, Jean-Pascal Lefaucheur, Ulrich Palm
Multiple sclerosis (MS), a chronic progressive inflammatory disease of the central nervous system, causes frequent disability, mood disorders, fatigue, and cognitive dysfunction. As a part of the last, social cognition is frequently disturbed in MS patients. It comprises empathy and social perception of emotions from facial, bodily and vocal cues. Social cognitive deficits worsen affect decoding, interpersonal relationship, and quality of life. Despite the impact of these deficits on global functioning, only a small number of studies have investigated its correlations and overlaps with MS symptoms...
November 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29163185/orthostatic-intolerance-in-older-persons-etiology-and-countermeasures
#15
REVIEW
Nandu Goswami, Andrew P Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162058/cognitive-rehabilitation-and-mindfulness-in-multiple-sclerosis-remind-ms-a-study-protocol-for-a-randomised-controlled-trial
#16
Ilse M Nauta, Anne E M Speckens, Roy P C Kessels, Jeroen J G Geurts, Vincent de Groot, Bernard M J Uitdehaag, Luciano Fasotti, Brigit A de Jong
BACKGROUND: Cognitive problems frequently occur in patients with multiple sclerosis (MS) and profoundly affect their quality of life. So far, the best cognitive treatment options for MS patients are a matter of debate. Therefore, this study aims to investigate the effectiveness of two promising non-pharmacological treatments: cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT). Furthermore, this study aims to gain additional knowledge about the aetiology of cognitive problems among MS patients, since this may help to develop and guide effective cognitive treatments...
November 21, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29160739/neural-correlates-of-effort-dependent-and-effort-independent-cognitive-fatigue-components-in-patients-with-multiple-sclerosis
#17
Stefan Spiteri, Thomas Hassa, Dolores Claros-Salinas, Christian Dettmers, Mircea Ariel Schoenfeld
BACKGROUND: Among patients with multiple sclerosis (MS), fatigue is the most commonly reported symptom. It can be subdivided into an effort-dependent (fatigability) and an effort-independent component (trait-fatigue). OBJECTIVE: The objective was to disentangle activity changes associated with effort-independent "trait-fatigue" from those associated with effort-dependent fatigability in MS patients. METHODS: This study employed behavioral measures and functional magnetic imaging to investigate neural changes in MS patients associated with fatigue...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29159465/changes-in-disability-in-people-with-multiple-sclerosis-a-10-year-prospective-study
#18
David Conradsson, Charlotte Ytterberg, Lena von Koch, Sverker Johansson
BACKGROUND: Little is known about the long-term course of disability in relation with disease severity in people with multiple sclerosis (PwMS). OBJECTIVE: To explore changes in a broad spectrum of disability over 10 years in relation with disease severity in PwMS. METHODS: We conducted a longitudinal study of 155 PwMS who attended the MS Centre at Karolinska University Hospital, Stockholm. Disease severity was determined by the use of the Expanded Disability Status Scale (EDSS) and classified as mild MS (EDSS score 0-3...
November 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29159057/gray-matter-atrophy-patterns-in-multiple-sclerosis-a-10-year-source-based-morphometry-study
#19
Niels Bergsland, Dana Horakova, Michael G Dwyer, Tomas Uher, Manuela Vaneckova, Michaela Tyblova, Zdenek Seidl, Jan Krasensky, Eva Havrdova, Robert Zivadinov
Objectives: To investigate spatial patterns of gray matter (GM) atrophy and their association with disability progression in patients with early relapsing-remitting multiple sclerosis (MS) in a longitudinal setting. Methods: Brain MRI and clinical neurological assessments were obtained in 152 MS patients at baseline and after 10 years of follow-up. Patients were classified into those with confirmed disability progression (CDP) (n = 85) and those without CDP (n = 67) at the end of the study...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29158119/contrasting-relationship-between-depression-quantitative-gait-characteristics-and-self-report-walking-difficulties-in-people-with-multiple-sclerosis
#20
Alon Kalron, Roy Aloni
The purpose of this study was to examine the relationship between depression and walking in the multiple sclerosis (MS) community. This study included 132 people with MS (PwMS) (80 women), mean EDSS 2.9 (S.D. = 1.7). Depression was assessed by the Hospital Anxiety and Depression Scale questionnaire. Spatio-temporal parameters of gait were studied using an electronic walkway. Participants filled out a valid self-rated measure of walking ability, the Multiple Sclerosis Walking Scale (MSWS-12) questionnaire. Computerized cognitive scores were included in the analysis in a multivariable analysis...
October 18, 2017: Multiple Sclerosis and related Disorders
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