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Multiple sclerosis cognition

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https://www.readbyqxmd.com/read/29684789/bipedal-hopping-timed-to-a-metronome-to-detect-impairments-in-anticipatory-motor-control-in-people-with-mild-multiple-sclerosis
#1
Megan C Kirkland, Alice Chen, Matthew B Downer, Brett J Holloway, Elizabeth M Wallack, Evan J Lockyer, Natasha C M Buckle, Courtney L Abbott, Michelle Ploughman
BACKGROUND: People with mild multiple sclerosis (MS) often report subtle deficits in balance and cognition but display no measurable impairment on clinical assessments. We examined whether hopping to a metronome beat had the potential to detect anticipatory motor control deficits among people with mild MS (Expanded Disability Status Scale ≤ 3.5). METHODS: Participants with MS (n = 13), matched controls (n = 9), and elderly subjects (n = 13) completed tests of cognition (Montreal Cognitive Assessment (MoCA)) and motor performance (Timed 25 Foot Walk Test (T25FWT))...
April 13, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29672097/cognitive-and-affective-mechanisms-of-pain-and-fatigue-in-multiple-sclerosis
#2
Anne Arewasikporn, Aaron P Turner, Kevin N Alschuler, Abbey J Hughes, Dawn M Ehde
OBJECTIVE: To examine the extent to which pain catastrophizing, fatigue catastrophizing, positive affect, and negative affect simultaneously mediated the associations between common symptoms of multiple sclerosis (MS; i.e., pain, fatigue) and impact on daily life, depressive symptoms, and resilience. METHOD: Participants were community-dwelling adults with MS (N = 163) reporting chronic pain, fatigue, and/or moderate depressive symptoms. Multiple mediation path analysis was used to model potential mediators of pain and fatigue separately, using baseline data from a randomized controlled trial comparing two symptom self-management interventions...
April 19, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29670565/the-efficacy-of-psychological-interventions-for-managing-fatigue-in-people-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#3
Aung Zaw Zaw Phyo, Thibaut Demaneuf, Alysha M De Livera, George A Jelinek, Chelsea R Brown, Claudia H Marck, Sandra L Neate, Keryn L Taylor, Taylor Mills, Emily O'Kearney, Amalia Karahalios, Tracey J Weiland
Background: Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system. Fatigue is commonly reported by people with MS (PwMS). MS-related fatigue severely affects daily activities, employment, socioeconomic status, and quality of life. Objective: We conducted this systematic review and meta-analysis to determine whether psychological interventions are effective in managing fatigue in PwMS. Data sources: We performed systematic searches of Medline, EMBASE, PsycINFO, and CINAHL to identify relevant articles published from database inception to April 5, 2017...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29670491/a-longitudinal-evaluation-of-cognitive-fatigue-on-a-task-of-sustained-attention-in-early-relapsing-remitting-multiple-sclerosis
#4
Jason A Berard, Andra M Smith, Lisa A S Walker
Background: Cognitive fatigue can be objectively measured on tasks of sustained attention and can be defined as decreased performance as a result of sustained cognitive effort. Individuals with multiple sclerosis (MS) early in their disease are vulnerable to cognitive fatigue, although this has yet to be evaluated longitudinally. We aimed to evaluate cognitive fatigue over a 3-year interval in individuals with early-phase relapsing-remitting MS (RRMS). The sensitivity of the Paced Auditory Serial Addition Test (PASAT) at detecting cognitive fatigue was evaluated, as was the impact of scoring method...
March 2018: International Journal of MS Care
https://www.readbyqxmd.com/read/29670407/first-episode-psychosis-as-the-initial-presentation-of-multiple-sclerosis-a-case-report
#5
Athena Enderami, Rose Fouladi, Seyed Hamzeh Hosseini
Background: Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system (CNS). MS with episode of psychosis is a rare entity, and to the best of our knowledge, no case has been reported from Iran till date. Case presentation: We report a case of MS with first-episode psychosis in a 27-year-old single man with no history of psychiatric disorder or drug abuse. The patient developed neurological symptoms after 3 months and was finally diagnosed as a case of MS...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29663869/the-effect-of-self-assessed-fatigue-and-subjective-cognitive-impairment-on-work-capacity-the-case-of-multiple-sclerosis
#6
Gisela Kobelt, Dawn Langdon, Linus Jönsson
OBJECTIVES: The impact of physical disability in multiple sclerosis on employment is well documented but the effect of neurological symptoms has been less well studied. We investigated the independent effect of self-reported fatigue and cognitive difficulties on work. METHODS: In a large European cost of illness survey, self-reported fatigue, subjective cognitive impairment (SCI), and productivity at work were assessed with visual analogue scales (VAS 0-10). The analysis controlled for country, age, age at diagnosis, gender, education, and physical disability...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29658343/older-age-higher-perceived-disability-and-depressive-symptoms-predict-the-amount-and-severity-of-work-related-difficulties-in-persons-with-multiple-sclerosis
#7
Raggi Alberto, Ambra Mara Giovannetti, Silvia Schiavolin, Laura Brambilla, Greta Brenna, Paolo Agostino Confalonieri, Francesca Cortese, Rita Frangiamore, Matilde Leonardi, Renato Emilio Mantegazza, Marco Moscatelli, Michela Ponzio, Valentina Torri Clerici, Paola Zaratin, Laura De Torres
PURPOSE: This cross-sectional study aims to identify the predictors of work-related difficulties in a sample of employed persons with multiple sclerosis as addressed with the Multiple Sclerosis Questionnaire for Job Difficulties. MATERIALS AND METHODS: Hierarchical linear regression analysis was conducted to identify predictors of work difficulties: predictors included demographic variables (age, formal education), disease duration and severity, perceived disability and psychological variables (cognitive dysfunction, depression and anxiety)...
April 16, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29656271/spanish-validation-of-a-specific-measure-to-assess-work-related-problems-in-people-with-multiple-sclerosis-the-multiple-sclerosis-work-difficulties-questionnaire-mswdq-23
#8
María L Martínez-Ginés, Jose M García-Domínguez, Lucía Forero, Neus Canal, Pablo Rebollo, Daniel Prefasi, Cynthia A Honan, Jorge Maurino
INTRODUCTION: Unemployment is a significant problem for people with multiple sclerosis (MS). The MS Work Difficulties Questionnaire (MSWDQ-23) is a self-report tool to assess work-related problems in people with MS across three domains: physical, psychological/cognitive, and external barriers. The aim of this study was to assess the psychometric properties of the Spanish version of the MSWDQ-23. METHODS: A multicentre, non-interventional, cross-sectional study in adult patients with relapsing-remitting multiple sclerosis (RRMS) or primary progressive (PPMS) multiple sclerosis (McDonald 2010 criteria) was conducted...
April 3, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29649969/magnetic-resonance-imaging-for-assessment-of-cerebrovascular-reactivity-and-its-relationship-to-cognition-a-systematic-review
#9
Sarah J Catchlove, Andrew Pipingas, Matthew E Hughes, Helen Macpherson
BACKGROUND: Cerebrovascular reactivity (CVR) refers to the responsiveness of cerebral vasculature to vasoactive stimuli. CVR is an indicator of brain health and can be assessed using vasodilatory techniques and magnetic resonance imaging (MRI). Using such approaches, some researchers have explored the relationship between CVR and cognition; here we systematically review this work. RESULTS: We extracted information pertaining to: (1) study location and design, participant characteristics, sample sizes, (2) design of vascular challenge, end-tidal CO 2 (etCO 2 ) concentrations (if applicable), (3) MRI protocol, (4) cognitive assessment, (5) CVR values, and outcomes of statistical analyses with cognitive tests...
April 12, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29649789/improving-fatigue-in-multiple-sclerosis-by-smartphone-supported-energy-management-the-ms-telecoach-feasibility-study
#10
Marie D'hooghe, Geert Van Gassen, Daphne Kos, Olivier Bouquiaux, Melissa Cambron, Danny Decoo, Andreas Lysandropoulos, Bart Van Wijmeersch, Barbara Willekens, Iris-Katharina Penner, Guy Nagels
BACKGROUND: Fatigue is a frequently occurring, often disabling symptom in MS with no single effective treatment. In current fatigue management interventions, personalized, real-time follow-up is often lacking. The objective of the study is to assess the feasibility of the MS TeleCoach, a novel intervention offering telemonitoring of fatigue and telecoaching of physical activity and energy management in persons with MS (pwMS) over a 12-week period. The goal of the MS TeleCoach, conceived as a combination of monitoring, self-management and motivational messages, is to enhance levels of physical activity thereby improving fatigue in pwMS in an accessible and interactive way, reinforcing self-management of patients...
March 27, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29649014/structural-mri-correlates-of-cognitive-event-related-potentials-in-multiple-sclerosis
#11
Artemios K Artemiadis, Maria C Anagnostouli, Ioannis G Zalonis, Konstantinos G Chairopoulos, Nikos I Triantafyllou
PURPOSE: Cognitive impairment in multiple sclerosis has been associated with cognitive event-related potentials and MRI abnormalities. This study aims to explore for the first time the association between P300 and MRI in multiple sclerosis. METHODS: Fifty-eight relapsing-remitting patients (41.5 ± 10.5 years old, 41 women, disease duration 139.7 ± 84.9 months) and 51 healthy controls were used. Visual P300 responses and a set of 2- or 3-dimensional MRI indices were obtained...
April 10, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29644797/altered-gastrointestinal-motility-involving-autoantibodies-in-the-experimental-autoimmune-encephalomyelitis-model-of-multiple-sclerosis
#12
E T Spear, E A Holt, E J Joyce, M M Haag, S M Mawe, G W Hennig, B Lavoie, A M Applebee, C Teuscher, G M Mawe
BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that, in addition to motor, sensory, and cognitive symptoms, also causes constipation, which is poorly understood. Here, we characterize gastrointestinal (GI) dysmotility in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS and evaluate whether autoantibodies target the enteric nervous system (ENS) and cause dysmotility. METHODS: EAE was induced in male SJL and B6 mice...
April 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29643001/immune-cell-bdnf-expression-in-treatment-na%C3%A3-ve-relapsing-remitting-multiple-sclerosis-patients-and-following-one-year-of-immunomodulation-therapy
#13
Alicja Kalinowska-Łyszczarz, Mikołaj A Pawlak, Aleksandra Wyciszkiewicz, Krystyna Osztynowicz, Wojciech Kozubski, Sławomir Michalak
Although neurons are the main source of neurotrophins in the healthy brain, neurotrophins can also be expressed in the immune system. We have previously shown that in relapsing-remitting multiple sclerosis (RRMS) lower immune-cell neurotrophin levels are associated with brain atrophy and cognitive impairment. The aim of the present study was to assess if immune-cell neurotrophin expression is impaired in MS as compared with the healthy controls, and to describe if these levels change in treatment-naïve RRMS patients, following one year of immunomodulation...
March 29, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29627034/comparison-of-the-abbreviated-minimal-assessment-of-cognitive-function-in-multiple-sclerosis-amacfims-and-the-brief-international-cognitive-assessment-for-multiple-sclerosis-bicams
#14
Elizabeth S Gromisch, Jeffrey G Portnoy, Frederick W Foley
BACKGROUND: Cognitive impairment is a prevalent and often intrusive problem among persons with multiple sclerosis (PwMS). Valid and reliable assessments, including quick screening measures, are crucial. The Brief International Cognitive Assessment for MS (BICAMS) was developed for this reason. While it lends itself to use in locations where formal neuropsychological resources might be limited, it does not include measures of verbal fluency or executive functioning, domains assessed as part of the Minimal Assessment of Cognitive Function in MS (MACFIMS)...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29627004/brain-connectivity-and-cognitive-processing-speed-in-multiple-sclerosis-a-systematic-review
#15
REVIEW
Riccardo Manca, Basil Sharrack, David Paling, Iain D Wilkinson, Annalena Venneri
BACKGROUND: Processing speed (PS) decline is the most commonly observed cognitive deficit in people with multiple sclerosis (MS) resulting in a significant impact on quality of life. Despite its importance, knowledge of the underlying neural substrates is lacking. OBJECTIVE: As MS is increasingly recognised as a disconnection syndrome, our aim was to carry out a systematic literature review to clarify the relationship between PS performance and MRI measures of structural and functional brain connectivity in people with MS...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29618808/fibrinogen-in-neurological-diseases-mechanisms-imaging-and-therapeutics
#16
REVIEW
Mark A Petersen, Jae Kyu Ryu, Katerina Akassoglou
The blood coagulation protein fibrinogen is deposited in the brain in a wide range of neurological diseases and traumatic injuries with blood-brain barrier (BBB) disruption. Recent research has uncovered pleiotropic roles for fibrinogen in the activation of CNS inflammation, induction of scar formation in the brain, promotion of cognitive decline and inhibition of repair. Such diverse roles are possible in part because of the unique structure of fibrinogen, which contains multiple binding sites for cellular receptors and proteins expressed in the nervous system...
April 5, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29618280/progressive-resistance-exercise-training-and-changes-in-resting-state-functional-connectivity-of-the-caudate-in-persons-with-multiple-sclerosis-and-severe-fatigue-a-proof-of-concept-study
#17
Nadine Akbar, Brian M Sandroff, Glenn R Wylie, Lauren B Strober, Angela Smith, Yael Goverover, Robert W Motl, John DeLuca, Helen Genova
Fatigue is one of the most disabling symptoms of multiple sclerosis (MS). While progressive resistance training (PRT) has been shown to reduce fatigue in persons with MS, it is not clear why these reductions occur. One hypothesis is that PRT may induce functional changes to the caudate, a region highly implicated in MS fatigue. The aim of the current study was to study the effects of PRT on overall fatigue impact and resting-state functional connectivity of the caudate in persons with MS reporting severe fatigue...
April 4, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29617157/comparing-the-open-trial-selective-reminding-test-results-with-the-california-learning-verbal-test-ii-in-multiple-sclerosis
#18
Silvana L Costa, John DeLuca, Kristen Costanza, Nancy D Chiaravalloti
We compared the California Learning Verbal Test II (CVLT II) and the Open Trial-Selective Reminding Test (OT-SRT) in assessing learning in persons with Multiple Sclerosis. One-hundred and twelve participants with multiple sclerosis performed the OT-SRT and the CVLT II on two different days. All participants completed additional cognitive tests assessing information processing speed (IPS), working memory (WM), and executive functions (EF). By definition, all participants were identified as having impaired learning on the OT-SRT (i...
April 4, 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29611255/translational-validity-of-pasat-and-the-effect-of-fatigue-and-mood-in-patients-with-relapsing-remitting-ms-a-functional-mri-study
#19
Dessislava Iancheva, Anastasiya G Trenova, Kiril Terziyski, Sevdalina Kandilarova, Stefka Mantarova
RATIONALE, AIMS, AND OBJECTIVES: Paced Auditory Serial Addition Test (PASAT) is used for assessment of information processing speed, attention, and working memory, which are the most frequently affected cognitive domains in multiple sclerosis (MS) patients, and may be significantly affected by fatigue. However, the effect of fatigue and mood on the PASAT performance in MS patients translationally validated by fMRI has not been studied yet. The aim of this study is to investigate the translational validity of the PASAT, using fMRI during a paced visual serial addition test (PVSAT) paradigm in patients with relapsing remitting MS (RRMS) and to assess the impact of fatigue and mood on test performance...
April 3, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29609859/cognitive-behavioral-therapies-and-multiple-sclerosis-fatigue-a-review-of-literature
#20
REVIEW
Moussa A Chalah, Samar S Ayache
BACKGROUND: Patients with multiple sclerosis (MS) commonly suffer from fatigue, a multidimensional symptom with physical, cognitive and psychosocial components that can drastically alter the quality of life. Despite its debilitating nature, the current treatment options are limited by their modest efficacy and numerous side effects. Cognitive behavioral therapies (CBT) have been applied in MS patients and might be of help in relieving fatigue. This constitutes the main objective of the current review...
March 30, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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