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https://www.readbyqxmd.com/read/29464459/a-diaper-pad-for-diaper-based-urine-collection-and-colorimetric-screening-of-urinary-biomarkers
#1
Haakon Karlsen, Tao Dong, Zhenhe Suo
The high prevalence of urinary tract infection in aging adults is a challenging aspect of geriatric care. Incontinence and cognitive/functional impairment make collection of urine samples difficult and often require either catheterization for sample collection, which is a risk factor for infections, or more lenient criteria for initiating antibiotic treatment. We report the development of a diaper inlay with absorbent materials, superabsorbent polymer-based valve and chemical reaction pads for rapid screening of urinary tract infection of incontinent diaper-wearing elderly receivers of home care services...
February 20, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29448938/comparative-genomic-analysis-of-ten-clinical-streptococcus-pneumoniae-collected-from-a-malaysian-hospital-reveal-31-new-unique-drug-resistant-snps-using-whole-genome-sequencing
#2
Hassan Mahmood Jindal, Babu Ramanathan, Cheng Foh Le, Ranganath Gudimella, Rozaimi Razali, Rishya Manikam, Shamala Devi Sekaran
BACKGROUND: Streptococcus pneumoniae or pneumococcus is a leading cause of morbidity and mortality worldwide, specifically in relation to community-acquired pneumonia. Due to the overuse of antibiotics, S. pneumoniae has developed a high degree of resistance to a wide range of antibacterial drugs. METHODS: In this study, whole genome sequencing (WGS) was performed for 10 clinical strains of S. pneumoniae with different levels of sensitivity to standard antibiotics...
February 15, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29432913/effects-of-fluconazole-on-the-clinical-outcome-and-immune-response-in-fungal-co-infected-tuberculosis-patients
#3
Xiaojuan Ren, Wei Liu, Yi Liu
With overuse of the broad-spectrum antibiotics, the pulmonary fungal infection increasingly becomes the most common complication associated with senile pulmonary tuberculosis (TB) and attracts intensive attentions from clinicians. Here we presented the retrospective analysis of impact of fluconazole treatment on the clinical outcome and immune response in fungal co-infected tuberculosis patients. A randomized, double-blind, placebo-controlled trial of fluconazole (100 mg per day for consecutive weeks) in fungal-positive senile tuberculosis patients was conducted in our hospital...
February 9, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29427192/community-acquired-respiratory-infections-are-common-in-patients-with-non-hodgkin-lymphoma-and-multiple-myeloma
#4
Noa Lavi, Irit Avivi, Zipora Kra-Oz, Ilana Oren, Emilia Hardak
PURPOSE: Available data suggest that respiratory infections are associated with increased morbidity and mortality in patients hospitalized due to acute leukemia and allogeneic stem cell transplantation (allo-SCT). However, the precise incidence, risk factors, and severity of respiratory infection, mainly community-acquired, in patients with lymphoma and multiple myeloma (MM) are not fully determined. The current study aimed to investigate risk factors for respiratory infections and their clinical significance in patients with B cell non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) in the first year of diagnosis...
February 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29422473/comparison-of-preoperative-and-perioperative-antibiotic-prophylaxis-regimen-in-compound-facial-fractures
#5
Veeranjaneyalu Mamthashri, Bokka Praveen Reddy
AIMS AND OBJECTIVES: Intraoperative antibiotics may be effective in elective surgery; there may be an advantage to starting antibiotics preoperatively when there is already an infective focus, such as compound facial fractures. The purpose of this study is to compare preoperative and intraoperative antibiotic prophylaxis in compound facial fractures. MATERIALS AND METHODS: This is a prospective study conducted over a period of 2 years on 50 patients, who underwent open reduction and rigid internal fixation...
February 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29421548/bacteria-responsive-intelligent-wound-dressing-simultaneous-in-situ-detection-and-inhibition-of-bacterial-infection-for-accelerated-wound-healing
#6
Jin Zhou, Danyu Yao, Zhiyong Qian, Sen Hou, Linhao Li, A Tobias A Jenkins, Yubo Fan
The evolved resistance of antibiotics exhibited by some dreaded clinical pathogens and formation of biofilms has caused life-threatening problems for patients with burns and other wounds. Here, in order to avoid antibiotic overuse, and thus decreasing the occurrence of antimicrobial-resistant bacteria, a theranostic wound dressing, composed of biocompatible UV-photocrosslinkable methacrylated gelatin (GelMA) encapsulating both antimicrobial and fluorescent vesicles, has been developed. The system can respond to the microbiological environment of the wound via a simple color change and antimicrobials release only when require and this is in essence passive as they do not respond to their local environments and benign bacteria, and only operates when pathogenic bacteria exist...
January 18, 2018: Biomaterials
https://www.readbyqxmd.com/read/29417002/antibiotic-prescribing-knowledge-attitudes-and-practice-among-physicians-in-teaching-hospitals-in-south-india
#7
Nimmy Thakolkaran, A Veena Shetty, Neevan D R D'Souza, Avinash K Shetty
Background: Antibiotic overuse is a major public health challenge worldwide. Data from India related to physician antibiotic prescribing patterns are limited. Aims: We assessed antibiotic prescribing knowledge, attitudes, and practices among physicians in Mangalore, South India. Materials and Methods: Using a cross-sectional descriptive study design, physicians at academic tertiary hospitals completed an anonymous on-site survey. The survey items incorporated Likert scales, and data were analyzed using SPSS version 15...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29412797/frequency-determination-of-carbapenem-resistant-klebsiella-pneumoniae-crkp-isolated-from-hospitals-in-isfahan-of-iran-and-evaluation-of-synergistic-effect-of-colistin-and-meropenem-on-them
#8
Leila Gheitani, Hossein Fazeli, Sharareh Moghim, Bahram Nasr Isfahani
Overuse and misuse of Carbapenems among Klebsiella pneumoniae isolates have caused Carbapenem-Resistant Klebsiella Pneumonia (CRKP) during recent years. Colistin is one of the last available options, and there are increasing concerns about the dosage and resistance to this agent in long-term monotherapies. This study was designed to identification of carbapenemase producing isolates of K. pneumoniae via phenotypic and genotypic methods as well as evaluation of colistin-meropenem combination therapy potential...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29409577/proper-antibiotic-use-in-a-home-based-primary-care-population-treated-for-urinary-tract-infections
#9
Megan E Gee, James Ford, Erin L Conway, Michael C Ott, John A Sellick, Kari A Mergenhagen
OBJECTIVE: To evaluate the trends associated with diagnosis and treatment of urinary tract infections (UTI) in a home-based primary care population of Veterans Health System patients from 2006 to 2015. DESIGN: Retrospective cohort study. SETTING: Veterans Healthcare System. PARTICIPANTS: Home-based primary care patients treated for UTI from 2006 to 2015. INTERVENTIONS: None. MAIN OUTCOME MEASURE: Appropriate therapy was determined based on the McGeer criteria...
February 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29405833/evidence-based-use-of-perioperative-antibiotics-in-otolaryngology
#10
Priyesh N Patel, Asitha D L Jayawardena, Rachel L Walden, Edward B Penn, David O Francis
Objective To identify and clarify current evidence supporting and disputing the effectiveness of perioperative antibiotic use for common otolaryngology procedures. Data Sources PubMed, Embase (OVID), and CINAHL (EBSCO). Review Methods English-language, original research (systematic reviews/meta-analyses, randomized control trials, prospective or retrospective cohort studies, case-control studies, or case series) studies that evaluated the role of perioperative antibiotic use in common otolaryngology surgeries were systematically extracted using standardized search criteria by 2 investigators independently...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29405078/non-indicated-use-of-prophylactic-antibiotics-in-gynaecological-surgery-at-an-academic-tertiary-medical-centre
#11
Kevin M Kremer, Raymond T Foster, Erma Z Drobnis, Kassie J Hyde, Lisa M Brennaman
Surgical site infections (SSI) are the most common surgical complication. Perioperative antibiotics can reduce SSI when used properly. Despite guidelines from The American College of Obstetrics and Gynecology, non-indicated antibiotic use is widespread which exposes women to unnecessary risks. This study represents a quality improvement analysis assessing surgeon compliance with established guidelines regarding antibiotic use in gynaecological surgery. This is a single centre, retrospective study examining gynaecological procedures over two years...
February 6, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29402125/management-of-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-current-evidence-and-future-prospects
#12
Chau-Chyun Sheu, Shang-Yi Lin, Ya-Ting Chang, Chun-Yuan Lee, Yen-Hsu Chen, Po-Ren Hsueh
The spread of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae has become a major public health threat worldwide. Area covered: A thorough systematic literature review describing the current evidence and future prospects of therapeutic options for infections caused by ESBL-producing Enterobacteriaceae. Expert commentary: The methods of detecting ESBLs have been evolving. The Clinical and Laboratory Standards Institute and the European Committee on Antimicrobial Susceptibility Testing lowered the MIC breakpoints of cephalosporins against ESBL-producing Enterobacteriaceae in 2010...
February 6, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29396511/reducing-antibiotic-utilization-rate-in-preterm-infants-a-quality-improvement-initiative
#13
Ramachandra Bhat, Haidee Custodio, Cathy McCurley, Richard Whitehurst, Rashmi Gulati, Om Prakash Jha, Jayalakshmi Bhat, Benjamin Estrada, Amy Hill, Fabien Eyal, Michael Zayek
BACKGROUND: Judicious use of antibiotic therapy in preterm infants is necessary as prolonged and unwarranted use of antibiotics have been associated with adverse short-term and long-term outcomes. LOCAL PROBLEM: Our baseline data review revealed overuse and unnecessary prolonged antibiotic exposure among preterm infants despite a low suspicion for sepsis. METHODS AND INTERVENTIONS: The baseline overall AUR was calculated retrospectively from our pharmacy database for a period of 4 months prior to the quality improvement (QI) initiative (pre-QI phase)...
February 2, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29391364/overuse-of-diagnostic-tools-and-medications-in-acute-rhinosinusitis-in-spain-a-population-based-study-the-prosinus-study
#14
Francesca Jaume, Llorenç Quintó, Isam Alobid, Joaquim Mullol
OBJECTIVES: Acute rhinosinusitis (ARS) has a high incidence. Diagnosis is clinical, and evolution is mostly self-limited. The aim of this study was to describe the sociodemographic characteristics and use of diagnostic tools and medications in patients with ARS. DESIGN: This is a prospective observational study in real-life clinical practice. SETTING: Patients with clinical diagnosis of ARS (n=2610) were included from ear, nose and throat clinics in Spain...
January 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29371833/effects-of-prescription-restrictive-interventions-on-antibiotic-procurement-in-primary-care-settings-a-controlled-interrupted-time-series-study-in-china
#15
Yuqing Tang, Chaojie Liu, Zinan Zhang, Xinping Zhang
Background: The overuse of antibiotics has been identified as a major challenge in regard to the rational prescription of medicines in low and middle income countries. Extensive studies on the effectiveness of persuasive interventions, such as guidelines have been undertaken. There is a dearth of research pertaining to the effects of restrictive interventions. This study aimed to evaluate the impacts of prescription restrictions in relation to types and administration routes of antibiotics on antibiotic procurement in primary care settings in China...
2018: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/29371558/strategies-to-reduce-mortality-in-adult-and-neonatal-candidemia-in-developing-countries
#16
REVIEW
Harsimran Kaur, Arunaloke Chakrabarti
Candidemia, the commonest invasive fungal infection, is associated with high morbidity and mortality in developing countries, though the exact prevalence is not known due to lack of systematic epidemiological data from those countries. The limited studies report a very high incidence of candidemia and unique epidemiology with a different spectrum of Candida species. The recent global emergence of multi-drug resistant Candida auris is looming large as an important threat in hospitalized patients of developing countries...
July 19, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29371505/gaining-insights-from-candida-biofilm-heterogeneity-one-size-does-not-fit-all
#17
REVIEW
Ryan Kean, Christopher Delaney, Ranjith Rajendran, Leighann Sherry, Rebecca Metcalfe, Rachael Thomas, William McLean, Craig Williams, Gordon Ramage
Despite their clinical significance and substantial human health burden, fungal infections remain relatively under-appreciated. The widespread overuse of antibiotics and the increasing requirement for indwelling medical devices provides an opportunistic potential for the overgrowth and colonization of pathogenic Candida species on both biological and inert substrates. Indeed, it is now widely recognized that biofilms are a highly important part of their virulence repertoire. Candida albicans is regarded as the primary fungal biofilm forming species, yet there is also increasing interest and growing body of evidence for non-Candida albicans species (NCAS) biofilms, and interkingdom biofilm interactions...
January 15, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29370366/national-patterns-of-urine-testing-during-inpatient-admission
#18
Molly J Horstman, Andrew Spiegelman, Aanand D Naik, Barbara W Trautner
Background: Overuse of urine testing is a driver of inappropriate antimicrobial use. Limiting wasteful testing is important for patient safety. We examined the national prevalence and patterns of urine testing during adult inpatient admission in the United States. Methods: We performed a retrospective cohort study using a national dataset of inpatient admissions from 263 hospitals in the United States from 2009 to 2014. We included all adult inpatient admissions, excluding those related to pregnancy, urology procedures, and with lengths of stay >30 days...
October 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29353751/metagenomic-analysis-of-antibiotic-resistance-genes-in-coastal-industrial-mariculture-systems
#19
Jian-Hua Wang, Jian Lu, Yu-Xuan Zhang, Jun Wu, Yongming Luo, Hao Liu
The overuse of antibiotics has posed a propagation of antibiotic resistance genes (ARGs) in aquaculture systems. This study firstly explored the ARGs profiles of the typical mariculture farms including conventional and recirculating systems using metagenomics approach. Fifty ARGs subtypes belonging to 21 ARGs types were identified, showing the wide-spectrum profiles of ARGs in the coastal industrial mariculture systems. ARGs with multiple antibiotics resistance have emerged in the mariculure systems. The co-occurrence pattern between ARGs and microbial taxa showed that Proteobacteria and Bacteroidetes were potential dominant hosts of ARGs in the industrial mariculture systems...
January 9, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29351876/vital-signs-analysis-algorithm-detects-inflammatory-response-in-premature-infants-with-late-onset-sepsis-and-necrotizing-enterocolitis
#20
Leena B Mithal, Ram Yogev, Hannah L Palac, Daniel Kaminsky, Ilan Gur, Karen K Mestan
BACKGROUND: Nonspecific clinical signs and suboptimal diagnostic tests limit accurate identification of late onset sepsis (LOS) and necrotizing enterocolitis (NEC) in premature infants, resulting in significant morbidity and antibiotic overuse. An infant's systemic inflammatory response may be identified earlier than clinical suspicion through analysis of multiple vital signs by a computerized algorithm (RALIS). AIM: To evaluate the revised RALIS algorithm for detection of LOS and NEC in preterm infants...
January 16, 2018: Early Human Development
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