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https://www.readbyqxmd.com/read/29735482/cd71-erythroid-suppressor-cells-promote-fetomaternal-tolerance-through-arginase-2-and-pdl-1
#1
Cole Delyea, Najmeh Bozorgmehr, Petya Koleva, Garett Dunsmore, Shima Shahbaz, Vivian Huang, Shokrollah Elahi
Survival of the allogeneic pregnancy depends on the maintenance of immune tolerance to paternal alloantigens at the fetomaternal interface. Multiple localized mechanisms contribute to the fetal evasion from the mother's immune rejection as the fetus is exposed to a wide range of stimulatory substances such as maternal alloantigens, microbes and amniotic fluids. In this article, we demonstrate that CD71+ erythroid cells are expanded at the fetomaternal interface and in the periphery during pregnancy in both humans and mice...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29660361/maternal-and-fetal-outcome-after-cardiac-surgery-during-pregnancy-a-meta-analysis
#2
REVIEW
Nivedita Jha, Ajay Kumar Jha, Ramesh Chand Chauhan, Neelima Singh Chauhan
BACKGROUND: In the past, cardiac surgery during pregnancy has been associated with high risk of adverse maternal and fetal outcomes. Therefore, this meta-analysis was done to assess the fetomaternal risk after cardiac surgery during pregnancy using cardiopulmonary bypass in more recent studies. METHODS: The Medline, Embase and Cochrane library were searched to find studies from January 1 1990 to July 31 2016 without language restriction. We selected studies that included at least four women to report fetomaternal outcomes after cardiac surgery using cardiopulmonary bypass during pregnancy...
April 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29620671/intraplacental-choriocarcinoma-coexisting-with-fetomaternal-hemorrhage-case-report-chemotherapy-management-and-literature-review
#3
Qin She, Zhi Cheng, Darine El-Chaar, Feng Luo, Xiaoyan Guo, Shi Wu Wen
RATIONALE: Near-term intraplacental choriocarcinoma (IC) coexisting with massive fetomaternal hemorrhage (FMH) is rare, and its clinical course is poorly understood. Here, we report a new case from our hospital, with detailed discussion and literature review. PATIENT CONCERNS: A 21-year-old Chinese female at 35 weeks gestation was admitted to our hospital due to reduced fetal movement. Near-term IC coexisting with massive FMH was diagnosed after delivery. INTERVENTION: The mother and infant were followed 3 months after delivery...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29577513/placental-immune-state-shifts-with-gestational-age
#4
Emma L Lewis, Luz-Jeannette Sierra, Guillermo O Barila, Amy G Brown, Paige M Porrett, Michal A Elovitz
PROBLEM: Placental immunologic functions are implicated in both the maintenance of a healthy pregnancy and the pathogenesis of obstetric complications. Immune populations at the maternal-fetal interface are hypothesized to support fetomaternal tolerance, defend the fetus from infection, and contribute to labor initiation. Despite the many potential roles of placental immune cells in normal and abnormal pregnancy, little is known about placental immune population dynamics over gestation, particularly near parturition...
March 25, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29550945/advanced-abdominal-pregnancy-a-search-for-consensus-review-of-literature-along-with-case-report
#5
REVIEW
Minakshi Rohilla, Bharti Joshi, Vanita Jain, Neetimala, Shalini Gainder
BACKGROUND: Advanced abdominal pregnancy is a highly morbid form of extrauterine gestation that demands skilled management. Despite advancement in antenatal care and imaging modalities, undiagnosed cases of advanced abdominal pregnancies are still reported. We report a case of asymptomatic abdominal pregnancy with healthy fetus advanced till 40 + 4 weeks period of gestation. Her diagnosis was not established even after obstetrical evaluation and cesarean section at primary care hospital...
March 17, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29535930/prevalence-of-hypothyroidism-in-term-pregnancies-in-north-india
#6
Bharti Kalra, Meenu Choudhary, Meenakshi Thakral, Sanjay Kalra
Background: Hypothyroidism is common in pregnancy. No study has determined the prevalence of hypothyroidism in term pregnancies in India. Aim: This study aims to determine the prevalence and correlates of hypothyroidism in women who delivered at a center in Karnal, Haryana, North India. Results: Indoor records of all women who had delivered at this centre from April 2016 to March 2017 were reviewed. The prevalence of hypothyroidism was 12...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29437897/tlr9-toll-like-receptor-9-agonist-suppresses-angiogenesis-by-differentially-regulating-vegfa-vascular-endothelial-growth-factor-a-and-sflt1-soluble-vascular-endothelial-growth-factor-receptor-1-in-preeclampsia
#7
Biwei He, Xingyu Yang, Yamei Li, Ding Huang, Xin Xu, Wenjun Yang, Yan Dai, Huijuan Zhang, Zhengjun Chen, Weiwei Cheng
Preeclampsia is a common pregnancy-specific disorder characterized by elevated blood pressure and proteinuria. Activation of the maternal immune system and impaired placental angiogenesis are thought to contribute to the pathogenesis of preeclampsia. TLR9 (Toll-like receptor 9) plays a role in innate immunity, defending the organism against infection. The purpose of this study was to determine whether TLR9 inhibits angiogenesis at the fetomaternal interface under conditions of preeclampsia. We confirmed the downregulation of VEGFA (vascular endothelial growth factor A) and upregulation of TLR9 and sFLT1 (soluble vascular endothelial growth factor receptor 1) in placentas from preeclamptic women...
April 2018: Hypertension
https://www.readbyqxmd.com/read/29405965/trinucleate-uterine-epithelial-cells-as-evidence-for-white-tail-deer-trophoblast-binucleate-cell-migration-and-as-markers-of-placental-binucleate-cell-dynamics-in-a-variety-of-wild-ruminants
#8
F B Peter Wooding, David Osborn, Gary J Killian
INTRODUCTION: The unicellular trophoblast epithelium of all ruminants so far investigated contains 15-20% binucleate cells with numerous secretory granules. Electron microscope (EM) studies of the domesticated cow, ewe, goat and deer species have established that these BNC migrate out of the trophoblast epithelium to fuse with the apposed maternal uterine epithelial cells or derivative to form fetomaternal tissue throughout pregnancy. However there is one careful EM study of the trophoblast of a wild ruminant, the White-tail deer, which found the usual number of BNC but no evidence of any migration or fusion...
February 2018: Placenta
https://www.readbyqxmd.com/read/29361555/plac8-a-new-marker-for-human-interstitial-extravillous-trophoblast-cells-promotes-their-invasion-and-migration
#9
Wen-Lin Chang, Ya-Wei Liu, Yan-Li Dang, Xiang-Xiang Jiang, Honglin Xu, Xing Huang, Yan-Ling Wang, Haibin Wang, Cheng Zhu, Li-Qun Xue, Hai-Yan Lin, Wenxiang Meng, Hongmei Wang
Proper differentiation of trophoblast cells in the human placenta is a prerequisite for a successful pregnancy, and dysregulation of this process may lead to malignant pregnancy outcomes, such as preeclampsia. Finding specific markers for different types of trophoblast cells is essential for understanding trophoblast differentiation. Here, we report that placenta-specific protein 8 (PLAC8) is specifically expressed in the interstitial extravillous trophoblast cells (iEVTs) on the fetomaternal interface. Using model systems, including placental villi-decidua co-culture, iEVTs induction by using primary trophoblast cells or explants, etc...
January 29, 2018: Development
https://www.readbyqxmd.com/read/29318985/a-randomised-controlled-trial-and-economic-evaluation-of-intraoperative-cell-salvage-during-caesarean-section-in-women-at-risk-of-haemorrhage-the-salvo-cell-salvage-in-obstetrics-trial
#10
Khalid S Khan, Philip Moore, Matthew Wilson, Richard Hooper, Shubha Allard, Ian Wrench, Tracy Roberts, Carol McLoughlin, Lee Beresford, James Geoghegan, Jane Daniels, Sue Catling, Vicki A Clark, Paul Ayuk, Stephen Robson, Fang Gao-Smith, Matthew Hogg, Louise Jackson, Doris Lanz, Julie Dodds
BACKGROUND: Caesarean section is associated with blood loss and maternal morbidity. Excessive blood loss requires transfusion of donor (allogeneic) blood, which is a finite resource. Cell salvage returns blood lost during surgery to the mother. It may avoid the need for donor blood transfusion, but reliable evidence of its effects is lacking. OBJECTIVES: To determine if routine use of cell salvage during caesarean section in mothers at risk of haemorrhage reduces the rates of blood transfusion and postpartum maternal morbidity, and is cost-effective, in comparison with standard practice without routine salvage use...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29261655/cell-salvage-and-donor-blood-transfusion-during-cesarean-section-a-pragmatic-multicentre-randomised-controlled-trial-salvo
#11
RANDOMIZED CONTROLLED TRIAL
Khalid S Khan, Philip A S Moore, Matthew J Wilson, Richard Hooper, Shubha Allard, Ian Wrench, Lee Beresford, Tracy E Roberts, Carol McLoughlin, James Geoghegan, Jane P Daniels, Sue Catling, Vicki A Clark, Paul Ayuk, Stephen Robson, Fang Gao-Smith, Matthew Hogg, Doris Lanz, Julie Dodds
BACKGROUND: Excessive haemorrhage at cesarean section requires donor (allogeneic) blood transfusion. Cell salvage may reduce this requirement. METHODS AND FINDINGS: We conducted a pragmatic randomised controlled trial (at 26 obstetric units; participants recruited from 4 June 2013 to 17 April 2016) of routine cell salvage use (intervention) versus current standard of care without routine salvage use (control) in cesarean section among women at risk of haemorrhage...
December 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29230092/fetomaternal-and-pediatric-toxoplasmosis
#12
Helieh S Oz
Toxoplasmosis is one of the most important causes of foodborne illnesses and inflammatory complications, as well as congenital disorders. Promiscuous Toxoplasma is transmitted by contaminated food and animal produce, water, vegetations, fruits and sexually through semen. Toxoplasma infects nucleated cells with a unique tropism for muscles and central nervous system and a mind bugging malicious effect. Pregnant women with acute or reactivated toxoplasmosis can transmit Toxoplasma via transplacental to the fetus...
December 2017: Journal of Pediatric Infectious Diseases
https://www.readbyqxmd.com/read/29191743/severe-neonatal-thrombocytopenia-due-to-fetomaternal-anti-a-alloimmunization-a-case-report
#13
Gerald Bertrand, Anne Leguen, Laurence Delugin, Virginie Renac
No abstract text is available yet for this article.
November 15, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29187052/mesenchymal-stem-cell-therapy-prevents-abortion-in-cba-j-%C3%A3-dba-2-mating
#14
Bizhan Sadighi-Moghaddam, Amir Salek Farrokhi, Hassan Namdar Ahmadabad, Mehdi Barati, Seyed Mohammad Moazzeni
Immunological disorders are among the main causes of recurrent spontaneous abortions (RSAs). Mesenchymal stem cells (MSCs) have been shown to modulate various aspects of immune responses. It seems that MSCs may improve the immunological conditions in immune-mediated RSA. The aim of this study is the reduction of resorption in RSA mouse model through MSCs therapy. The adipose-derived MSCs were administered intraperitoneal to pregnant CBA/J mice on day 4.5 of gestation in abortion-prone matting. On day 13.5 of pregnancy, abortion rates were calculated and transforming growth factor-β (TGF-β), interleukin 10 (IL-10), interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) gene expression in deciduas were evaluated by real-time polymerase chain reaction (PCR)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29138200/assessing-the-consequences-of-gestational-diabetes-mellitus-on-offspring-s-cardiovascular-health-mysweetheart-cohort-study-protocol-switzerland
#15
Stefano Di Bernardo, Yvan Mivelaz, Adina Mihaela Epure, Yvan Vial, Umberto Simeoni, Pascal Bovet, Sandrine Estoppey Younes, Arnaud Chiolero, Nicole Sekarski
INTRODUCTION: Gestational diabetes mellitus (GDM) is a state of glucose intolerance with onset during pregnancy. GDM carries prenatal and perinatal risks as well as long-term risks for the mother and her child. GDM may be involved in the foetal programming of long-term cardiovascular health. However, evidence is sparse and the effect of GDM on cardiovascular health is unknown. To address these issues, we will conduct MySweetHeart Cohort study. The objectives are to assess the effect of GDM on offspring's cardiovascular health early in life by using surrogate markers of cardiovascular disease and atherosclerosis...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29072803/the-presence-of-f-cells-with-a-fetal-phenotype-in-adults-with-hemoglobinopathies-limits-the-utility-of-flow-cytometry-for-quantitation-of-fetomaternal-hemorrhage
#16
Jad Othman, Daniel Orellana, Lin Selina Chen, Megan Russell, Teh-Liane Khoo
BACKGROUND: Detection and quantitation of fetomaternal hemorrhage (FMH) can be difficult in patients with pre-existing elevations of HbF, such as those with hemoglobinopathies. The aim of this study was to evaluate the utility of dual-color flow cytometry with the Fetal Cell Count Kit (FCCK) in differentiating adult and fetal HbF in this population, as compared to flow cytometry (FC) using HbF alone. METHODS: Peripheral blood was obtained from normal adults and patients with hemoglobinopathies (β-thalassemia and sickle cell disease), including a small number of pregnant females...
October 26, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29071724/risk-factors-for-fetomaternal-bleeding-after-laser-therapy-for-twin-twin-transfusion-syndrome
#17
Andrew H Chon, Lisa M Korst, Brendan H Grubbs, Eftichia V Kontopoulos, Rubén A Quintero, Ramen H Chmait
OBJECTIVE: To quantify and assess potential risk factors for transplacental passage of fetal red blood cells (RBCs) into the maternal circulation (fetomaternal bleeding, FMB) after laser surgery for twin-twin transfusion syndrome (TTTS). STUDY DESIGN: A retrospective study of Rhesus-D negative patients that underwent laser surgery for TTTS. Patients with and without postoperative detectable fetal RBCs on Kleihauer-Betke (KB) testing were compared to determine risk factors for FMB...
December 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29055961/plac1-expression-pattern-at-the-mouse-fetomaternal-interface-and-involvement-in-trophoblast-differentiation
#18
Yanli Gu, Junhui Wan, Lv Yao, Nan-Ni Peng, Wen-Lin Chang
BACKGROUND/AIMS: It is well known that Plac1 is a placenta-specific gene; however, its spatiotemporal expression pattern and exact role at t h e mouse fetomaternal interface r e m a i n s unclear. METHODS: In situ hybridization (ISH) was used to localize the Plac1 mRNA at the mouse fetomaternal interface. A trophoblast stem cell (TS) differentiation model with Plac1 shRNA-overexpressing lentivirus was employed to investigate the possible role of Plac1 in placentation...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29037175/a-ten-year-study-of-midwife-led-care-at-an-austrian-tertiary-care-center-a-retrospective-analysis-with-special-consideration-of-perineal-trauma
#19
Barbara Bodner-Adler, Oliver Kimberger, Julia Griebaum, Peter Husslein, Klaus Bodner
BACKGROUND: In contrast to other countries, Austria rarely offers alternative models to medical led-care. In an attempt to improve the facilities, a midwife-led care service was incorporated within the Department of Obstetrics and Fetomaternal Medicine. The aim of the present study was to analyze the maternal and neonatal outcomes of this approach. METHODS: Over a 10-years period, a total of 2123 low-risk women receiving midwife-led care were studied. Among these women, 148 required obstetric referral...
October 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28962689/a-lectin-histochemical-study-to-detect-variation-in-glycosylation-at-the-feto-maternal-interface-in-three-interbreeding-equine-species
#20
Carolyn J P Jones, W R Twink Allen, Sandra Wilsher
INTRODUCTION: In this study, we compare glycosylation at the fetomaternal interface in 3 equine species: horse, donkey and zebra, all of which can interbreed to produce hybrids, to assess their glycan similarities and differences. METHODS: Sections cut from 3 specimens of horse (Equus caballus) placenta (50, 200 and 280 days gestation), one donkey (Equus asinus) placenta (65 cm crown-rump length) and 5 specimens of zebra (Equus quagga) placentae (81-239 days gestation) were stained with a panel of 24 biotinylated lectins using an avidin-peroxidase revealing system...
October 2017: Placenta
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