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https://www.readbyqxmd.com/read/28761227/acute-kidney-injury-in-pregnancy-specific-disorders
#1
REVIEW
J Prakash, V C Ganiger
The incidence of acute kidney injury in pregnancy (P-AKI) has declined significantly over the last three decades in developing countries. However, it is still associated with significant fetomaternal mortality and morbidity. The diagnosis of P-AKI is based on the serum creatinine increase. The usual formulas for estimating glomerular filtration rate (GFR) are not validated in this population. The incidence of P-AKI with respect to total AKI cases has decreased in the last three decades from 25% in 1980s to 9% in 2000s at our centre...
July 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28679758/a-cell-fusion-based-screening-method-identifies-the-gpi-anchored-protein-ly6e-as-the-receptor-for-the-mouse-endogenous-retroviral-envelope-syncytin-a
#2
Agathe Bacquin, Caroline Bireau, Maxime Tanguy, Charlotte Romanet, Cécile Vernochet, Anne Dupressoir, Thierry Heidmann
Syncytins are envelope genes of retroviral origin that have been exapted for a role in placentation. They are involved in the formation of a syncytial structure (the syncytiotrophoblast) at the fetomaternal interface via their fusogenic activity. The mouse placenta is rather unique among placental mammals since the fetomaternal interface comprises two syncytiotrophoblast layers (ST-I and ST-II) instead of one, as observed in humans and all other hemochorial placentae. Each layer specifically expresses a distinct mouse syncytin, namely syncytin-A (SynA) for ST-I and syncytin-B (SynB) for ST-II, which have been shown to be essential to placentogenesis and embryo survival...
July 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28584742/antepartum-hemorrhage-a-retrospective-analysis-from-a-northern-nigerian-teaching-hospital
#3
Idris Usman Takai, Badia Maje Sayyadi, Hadiza Shehu Galadanci
BACKGROUND: Antepartum hemorrhage (APH) contributes significantly to maternal and perinatal morbidity and mortality globally, particularly in the developing world like ours. Prevention, early detection, and prompt management cannot be overemphasized to significantly reduce the morbidity and mortality associated with this condition. OBJECTIVES: The study is aimed at determining the prevalence, etiology, sociodemographic characteristics, and the fetomaternal outcome of pregnancies complicated by APH in Aminu Kano Teaching Hospital, Kano...
April 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28574640/trigeminal-neuralgia-in-pregnancy-a-management-challenge
#4
Bhanu P Swain, Sri Vidhya, Ashok Jadon, Kumar N Chandra, Sharad K Sinha
Pregnancy is known to aggravate pre-existing chronic painful conditions. Trigeminal neuralgia (TN), albeit a disease of elderly may afflict pregnant females which can further complicate its management. Teratogenic effects of the commonly used drugs on the developing fetus limit pharmacological treatment. Moreover safety of commonly performed interventional therapies is marred by their inherent fetomaternal effects and more importantly the risk of radiation effects on fetus due to the use of fluoroscopy. This rare coexistence of TN in pregnancy is never reported before...
June 2, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28509414/the-normal-fetal-pancreas
#5
Zvi Kivilevitch, Reuven Achiron, Sharon Perlman, Yinon Gilboa
OBJECTIVES: The aim of the study was to assess the sonographic feasibility of measuring the fetal pancreas and its normal development throughout pregnancy. METHODS: We conducted a cross-sectional prospective study between 19 and 36 weeks' gestation. The study included singleton pregnancies with normal pregnancy follow-up. The pancreas circumference was measured. The first 90 cases were tested to assess feasibility. RESULTS: Two hundred ninety-seven fetuses of nondiabetic mothers were recruited during a 3-year period...
May 16, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28484250/maternal-depression-attenuates-newborn-vitamin-d-concentrations-in-winter-spring-a-prospective-population-based-study
#6
Qi-Fan Zhou, Meng-Xiao Zhang, Shi-Lu Tong, Rui-Xue Tao, Jia-Hu Hao, Kun Huang, Fang-Biao Tao, Peng Zhu
We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (25(OH)D) were measured in 1491 mother-infant pairs. Data on maternal sociodemographic characteristics, health status, lifestyle and birth outcomes were prospectively collected. For infants born in winter-spring, the infants of MD mothers had significantly reduced concentrations of 25(OH) D (adjusted β = -3...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28478827/mild-anemia-during-pregnancy-upregulates-placental-vascularity-development
#7
A Stangret, M Skoda, A Wnuk, M Pyzlak, D Szukiewicz
The connection between maternal hematological status and pregnancy outcome has been shown by many independent researchers. Attention was initially focused on the adverse effects of moderate and severe anemia. Interestingly, some studies revealed that mild anemia was associated with optimal fetal development and was not affecting pregnancy outcome. The explanation for this phenomenon became a target for scientists. Hemodilution, physiologic anemia and relative decrease in hemoglobin concentration are the changes observed during pregnancy but they do not explain the reasons for the positive influence of mild anemia on a fetomaternal unit...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28458479/gestational-gigantomastia-a-systematic-review-of-case-reports
#8
Mishu Mangla, Deepak Singla
INTRODUCTION: Gestational gigantomastia (GG) is a rare disease characterized by diffuse, extreme, and incapacitating enlargement of one or both breasts during pregnancy. Although benign, it can lead to a great social, emotional, and physical disability. A good and complete knowledge regarding this rare but distressing clinical situation is a must among all practicing physicians especially obstetricians. MATERIALS AND METHODS: A systematic review of all the case reports and short case series, published in the English language in various databases in the last 40 years, i...
January 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28419453/obstetrics-and-gynecology-physician-knowledge-of-rh-immune-globulin-prophylaxis
#9
Amy Yu, Erin Morris, Richard Adams, Mark K Fung
BACKGROUND: Previous studies have shown that more than 20% of laboratories would have recommended inaccurate doses of Rh immune globulin (RhIG) in hypothetical cases. Efforts have been made in educating laboratories in correct dosing calculations; however, obstetricians are most often responsible for ordering RhIG. The objective of this study was to assess knowledge of RhIG indications and dosing among obstetrics and gynecology (OB/GYN) physicians in the United States. STUDY DESIGN AND METHODS: An anonymous 17- question online survey was distributed to all OB/GYN resident and attending physicians affiliated with US residency training programs...
April 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28408909/the-maternal-diet-gut-bacteria-and-bacterial-metabolites-during-pregnancy-influence-offspring-asthma
#10
REVIEW
Lawrence E K Gray, Martin O'Hely, Sarath Ranganathan, Peter David Sly, Peter Vuillermin
This review focuses on the current evidence that maternal dietary and gut bacterial exposures during pregnancy influence the developing fetal immune system and subsequent offspring asthma. Part 1 addresses exposure to a farm environment, antibiotics, and prebiotic and probiotic supplementation that together indicate the importance of bacterial experience in immune programming and offspring asthma. Part 2 outlines proposed mechanisms to explain these associations including bacterial exposure of the fetoplacental unit; immunoglobulin-related transplacental transport of gut bacterial components; cytokine signaling producing fetomaternal immune alignment; and immune programming via metabolites produced by gut bacteria...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28367190/labour-induction-with-gestational-hypertension-a-great-obstetric-challenge
#11
Meharun-Nissa Khaskheli, Shahla Baloch, Aneela Sheeba, Sarmad Baloch, Fahad Khan
OBJECTIVE: To observe the fetomaternal morbidity and mortality with induction of labour in pregnant women with gestational hypertension. METHODS: The subjected study population included was 138 pregnant women with gestational hypertension. These pregnant women were between 34-40 weeks of gestational period in whom labour was induced, while the pregnant women who had labour induction for other reasons were excluded. These women were registered on the predesigned proforma...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28355226/considering-medical-risk-information-and-communicating-values-a-mixed-method-study-of-women-s-choice-in-prenatal-testing
#12
An Chen, Henni Tenhunen, Paulus Torkki, Seppo Heinonen, Paul Lillrank, Vedran Stefanovic
INTRODUCTION: Nowadays, an important decision for pregnant women is whether to undergo prenatal testing for aneuploidies and which tests to uptake. We investigate the factors influencing women's choices between non-invasive prenatal testing (NIPT) and invasive prenatal tests in pregnancies with elevated a priori risk of fetal aneuploidies. METHODOLOGY: This is a mixed-method study. We used medical data (1st Jan 2015-31st Dec 2015) about women participating in further testing at Fetomaternal Medical Center at Helsinki University Hospital and employed Chi-square tests and ANOVA to compare the groups of women choosing different methods...
2017: PloS One
https://www.readbyqxmd.com/read/28343180/oxygen-saturation-trends-in-normal-healthy-term-newborns-normal-vaginal-delivery-vs-elective-cesarean-section
#13
Rashi Bhargava, Madhu Mathur, Jyoti Patodia
OBJECTIVES: To study the normal oxygen saturation trends and fetomaternal correlates in healthy term newborns within 30 min of life born by normal vaginal delivery (NVD) and elective cesarean section (CS). MATERIALS AND METHODS: A cross-sectional study was conducted on 200 healthy term newborns born by NVD and elective CS at a tertiary care centre. Routine care as per the Neonatal Resuscitation Program (NRP) 2015 (Wyckoff MH, Aziz K, Escobedo MB, Kapadia VS, Kattwinkel J, Perlman JM, et al...
March 27, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28326960/placental-pathologic-features-in-fetomaternal-hemorrhage-detected-by-flow-cytometry
#14
Natasha E Lewis, Laura Marszalek, Linda M Ernst
Background Fetomaternal hemorrhage (FMH) is a poorly understood entity that can have significant clinical effects. Flow cytometry is a reliable and relatively new method for FMH diagnosis. The objective of this study was to correlate placental pathology with FMH detected by flow cytometry. Methods All patients with available placentas and FMH flow cytometric testing performed from 2009 to 2015 were retrospectively reviewed. Cases were defined as ≥0.10% fetal red blood cells (RBCs) in the maternal circulation while controls contained <0...
March 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28321338/frequency-risk-factors-and-adverse-fetomaternal-outcomes-of-placenta-previa-in-northern-tanzania
#15
Elizabeth Eliet Senkoro, Amasha H Mwanamsangu, Fransisca Seraphin Chuwa, Sia Emmanuel Msuya, Oresta Peter Mnali, Benjamin G Brown, Michael Johnson Mahande
Background and Objective. Placenta previa (PP) is a potential risk factor for obstetric hemorrhage, which is a major cause of fetomaternal morbidity and mortality in developing countries. This study aimed to determine frequency, risk factors, and adverse fetomaternal outcomes of placenta previa in Northern Tanzania. Methodology. A retrospective cohort study was conducted using maternally-linked data from Kilimanjaro Christian Medical Centre birth registry spanning 2000 to 2015. All women who gave birth to singleton infants were studied...
2017: Journal of Pregnancy
https://www.readbyqxmd.com/read/28168818/biochemical-analysis-of-intraplacental-choriocarcinoma-and-fetomaternal-transfusion
#16
Tatsuya Ishiguro, Kazuaki Suda, Takayuki Enomoto
Intraplacental choriocarcinoma is one of the rarest forms of gestational tumors and is believed to be one of the causes of fetomaternal transfusion (FMT). A 35-year-old woman, gravida 2, para 2, with a history of two vaginal deliveries, was incidentally diagnosed as having stage I gestational intraplacental choriocarcinoma with a FIGO/World Health Organization 2000 risk score of 2 after term delivery. This disease caused neonatal anemia but did not metastasize to either the mother or infant. Short tandem repeat analysis with laser microdissection revealed that the tumor had originated from the current pregnancy...
March 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28095355/immune-regulatory-network-in-successful-pregnancy-and-reproductive-failures
#17
REVIEW
Mahnaz Ghaebi, Mohammad Nouri, Aliyeh Ghasemzadeh, Laya Farzadi, Farhad Jadidi-Niaragh, Majid Ahmadi, Mehdi Yousefi
Maternal immune system must tolerate semiallogenic fetus to establish and maintain a successful pregnancy. Despite the existence of several strategies of trophoblast to avoid recognition by maternal leukocytes, maternal immune system may react against paternal alloantigenes. Leukocytes are important components in decidua. Not only T helper (Th)1/Th2 balance, but also regulatory T (Treg) cells play an important role in pregnancy. Although the frequency of Tregs is elevated during normal pregnancies, their frequency and function are reduced in reproductive defects such as recurrent miscarriage and preeclampsia...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28043350/evaluation-of-changes-in-doppler-ultrasonography-indices-and-levels-of-maternal-serum-angiogenic-factors-throughout-pregnancy-in-ewes
#18
Özge Turna Yilmaz, Mehmet Can Gündüz, Gamze Evkuran Dal, Melih Uçmak, Zeynep Günay Uçmak, Esra Karaçam, Güven Kaşikçi, Mehmet Ragip Kiliçarslan
We evaluated the changes in the pulsatility index (PI) and resistance index (RI) of fetal and maternal vessels and maternal serum angiogenic factors throughout pregnancy in 20 Kivircik ewes. They were examined for pregnancy detection on Day 30 after mating. The PI and RI during the pregnancies were followed using Doppler ultrasonography (USG) of the uterine artery, umbilical artery, fetal aorta, and fetal vena cava. Doppler USG was performed every 15 days beginning from the 40th day after mating. Blood samples were collected every 15 days starting from the day of mating...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28040144/a-case-of-fetomaternal-transfusion-in-trichorionic-triamniotic-triplets
#19
Yuko Teraoka, Osamu Samura, Yurika Mukai, Masaru Sasaki
No abstract text is available yet for this article.
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27999241/the-expression-of-t-helper-associated-transcription-factors-and-cytokine-genes-in-pre-eclampsia
#20
Behrouz Gharesi-Fard, Fatemeh Mobasher-Nejad, Fatemeh Nasri
BACKGROUND: Pre-eclampsia (PE) is known as a main factor contributing to fetomaternal mortality, which might affect 2-8% of all pregnancies after the twentieth week of gestation. The balance of T helper subsets is essential to sustain a normal pregnancy and preventing fetomaternal complications. OBJECTIVE: To investigate differences in the levels of transcription factors and cytokine gene expression of Th1/Th2/Th17/Treg subsets within decidual and chorionic layers of placentas from 15 PE-afflicted and 15 healthy Iranian women in their third trimester of pregnancy...
December 2016: Iranian Journal of Immunology: IJI
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