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https://www.readbyqxmd.com/read/29665872/maternal-intake-of-omega-3-and-omega-6-polyunsaturated-fatty-acids-during-mid-pregnancy-is-inversely-associated-with-linear-growth
#1
M Al-Hinai, A Baylin, M M Tellez-Rojo, A Cantoral, A Ettinger, M Solano-González, K E Peterson, W Perng
This study investigates relations of maternal N-3 and N-6 polyunsaturated fatty acids (PUFA) intake during pregnancy with offspring body mass index (BMI), height z-score and metabolic risk (fasting glucose, C-peptide, leptin, lipid profile) during peripuberty (8-14 years) among 236 mother-child pairs in Mexico. We used food frequency questionnaire data to quantify trimester-specific intake of N-3 alpha-linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); N-6 linoleic acid and arachidonic acid (AA); and N-6:N-3 (AA:EPA+DHA), which accounts for the fact that the two PUFA families have opposing effects on physiology...
April 18, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29659487/cultivar-and-harvest-month-influence-the-nutrient-content-of-opuntia-spp-cactus-pear-cladode-mucilage-extracts
#2
Alba du Toit, Maryna de Wit, Arno Hugo
Mucilage extracted from cactus pear cladodes is a hydrocolloid gum. It is a novel, natural, low-kilojoule, cost-effective texture-modifying ingredient in functional food products. Yet, the cultivar with the most optimal nutrient content and the preferred harvest times are as yet unknown. For this reason, mucilage from three Opuntia ficus-indica (Algerian, Morado and Gymno-Carpo) and one Opuntia robusta (Robusta) cultivar were investigated to determine their nutrient content over six months. Nutrients that contribute energy (10...
April 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29649756/transcriptional-effects-of-phospholipid-fatty-acid-profile-on-rainbow-trout-liver-cells-exposed-to-methylmercury
#3
Aline Ferain, Chloé Bonnineau, Ineke Neefs, Krishna Das, Yvan Larondelle, Jean-François Rees, Cathy Debier, Benjamin Lemaire
Lipids, and their constitutive fatty acids, are key nutrients for fish health as they provide energy, maintain cell structure, are precursors of signalling molecules and act as nuclear receptor ligands. These specific roles may be of crucial importance in a context of exposure to pollutants. We recently showed that the fatty acid profile of rainbow trout liver cell phospholipids modulates sensitivity to an acute methylmercury challenge. In order to investigate mechanisms of effects, we herein tested whether specific polyunsaturated fatty acids (PUFAs) may protect cells from methylmercury through decreasing intracellular mercury accumulation and/or enhancing cellular defences (e...
March 22, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29573696/low-omega-6-omega-3-ratio-in-a-maternal-protein-deficient-diet-promotes-histone-3-changes-in-progeny-neural-cells-and-favors-leukemia-inhibitory-factor-gene-transcription
#4
Alinny Rosendo Isaac, Emerson Alexandre Neves da Silva, Rhowena Jane Barbosa de Matos, Ricielle Lopes Augusto, Giselle Machado Magalhães Moreno, Ingrid Prata Mendonça, Raphael Fabrício de Souza, Paulo Euzébio Cabral-Filho, Cláudio Gabriel Rodrigues, Catarina Gonçalves-Pimentel, Fabíola Lacerda, Maria Luisa Martins Alessio, Marcelo Cairrão Araujo Rodrigues, Belmira Lara da Silveira Andrade-da-Costa
Omega-3 (n-3) fatty acids modulate epigenetic changes critical to genesis and differentiation of neural cells. Conversely, maternal protein-malnutrition can negatively modify these changes. This study investigated whether a low n-6/n-3 ratio in a maternal diet could favor histone-3 (H3) modifications, gene transcription and differentiation in the offspring neural cells even under protein-deficiency. Female rats fed a control (Ct), or 3 types of multideficient diets differing in protein levels or linoleic/alpha-linolenic fatty acid ratios (RBD, RBD-C, RBD-SO) from 30 days prior to mating and during pregnancy...
February 13, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29547735/adherence-to-a-mediterranean-diet-and-its-association-with-age-related-macular-degeneration-the-coimbra-eye-study-report-4
#5
Sandrina Nunes, Dalila Alves, Patrícia Barreto, Miguel Raimundo, Maria da Luz Cachulo, Cláudia Farinha, Inês Laíns, João Rodrigues, Carlos Almeida, Luísa Ribeiro, João Figueira, Lelita Santos, Rufino Silva
OBJECTIVES: This study aimed to characterize the association of lifestyle and nutritional risk profiles with age-related macular degeneration (AMD) in two subpopulations with differing AMD prevalence. METHODS: This case-control study (n = 1992) included 768 patients with AMD and 1224 age- and sex-matched participants without AMD with a single visit at a primary health care unit. Enrolled participants completed a validated lifestyle and food frequency questionnaire...
March 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29523147/omega-6-omega-3-fatty-acid-intake-of-children-and-older-adults-in-the-u-s-dietary-intake-in-comparison-to-current-dietary-recommendations-and-the-healthy-eating-index
#6
Kelly W Sheppard, Carol L Cheatham
BACKGROUND: Omega-6 and omega-3 fatty acids (FAs) and their ratio have been shown to affect cognitive function in children and older adults. With these analyses, we aimed to describe omega-6 and omega-3 FA intake among children and older adults in light of FA intake recommendations and with consideration of overall diet. METHODS: Data were merged from two cross-sectional studies with 219 children 7 to 12 years old and one longitudinal study with 133 adults 65 to 79 years old...
March 9, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29522992/multi-block-analysis-coupled-with-gc-fid-and-atr-mir-for-the-evaluation-of-thermal-degradation-in-vegetable-oils
#7
Valéria Rampazzo, Leomara Floriano Ribeiro, Poliana Macedo Santos, Maresa Custódio Molinari Ferreira, Evandro Bona, Giselle Maria Maciel, Charles Windson Isidoro Haminiuk
The effect of heating in twenty-four different oil samples was evaluated via iodine value (IV), gas chromatography (GC) and mid-infrared (MIR) analyses. Common components and specific weights analysis (CCSWA) was applied to distribute the samples according to their most relevant characteristics, thereby revealing the influence of heating on composition. Instrumental analysis indicated a high amount of beneficial fatty acids, such as alpha-linolenic acid, in less exploited oils such as chia oil. This oil can present nutritional damage when subjected to high temperatures and is thus less recommended for frying...
February 26, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29476327/improved-oil-quality-in-transgenic-soybean-seeds-by-rnai-mediated-knockdown-of-gmfad2-1b
#8
Jing Yang, Guojie Xing, Lu Niu, Hongli He, Dongquan Guo, Qian Du, Xueyan Qian, Yao Yao, Haiyun Li, Xiaofang Zhong, Xiangdong Yang
Soybean oil contains approximately 20% oleic acid and 63% polyunsaturated fatty acids, which limits its uses in food products and industrial applications because of its poor oxidative stability. Increasing the oleic acid content in soybean seeds provides improved oxidative stability and is also beneficial to human health. Endoplasmic reticulum-associated delta-12 fatty acid desaturase 2 (FAD2) is the key enzyme responsible for converting oleic acid (18:1) precursors to linoleic acid (18:2) in the lipid biosynthetic pathway...
February 23, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29452256/modulation-of-oxidative-stress-response-by-flaxseed-oil-role-of-lipid-peroxidation-and-underlying-mechanisms
#9
REVIEW
Rajnish Kumar Yadav, Manjari Singh, Subhadeep Roy, Mohd Nazam Ansari, Abdulaziz S Saeedan, Gaurav Kaithwas
Polyunsaturated fatty acids (PUFA's) are majorly classified as ω-3 and ω-6 fatty acids. The eicosapentaenoic acid (EPA, ω-3:20-5), docosahexaenoic acid (DHA, ω-3:22-6) and alpha-linolenic acid (ALA, ω-3:18-3) are known ω-3 fatty acids, extracted from animal (e.g fish oil) and plant sources (e.g flaxseed oil). Furthermore, linoleic acid (LA, ω-6:18-2) is recognized as ω-6 fatty acid and the most prominent biological fatty acid with a pro-inflammatory response. Flaxseed oil has variety of biological roles, due to a significant amount of ω-3/ω-6 fatty acids...
February 13, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29413364/arachidonic-acid-supplementation-modulates-blood-and-skeletal-muscle-lipid-profile-with-no-effect-on-basal-inflammation-in-resistance-exercise-trained-men
#10
James F Markworth, Cameron J Mitchell, Randall F D'Souza, Kirsten M M Aasen, Brenan R Durainayagam, Sarah M Mitchell, Alex H C Chan, Andrew J Sinclair, Manohar Garg, David Cameron-Smith
Arachidonic acid (ARA), an omega-6 polyunsaturated fatty acid (PUFA), is the metabolic precursor to the eicosanoid family of lipid mediators. Eicosanoids have potent pro-inflammatory actions, but also act as important autocrine/paracrine signaling molecules in skeletal muscle growth and development. Whether dietary ARA is incorporated into skeletal muscle phospholipids and the resulting impact on intramuscular inflammatory and adaptive processes in-vivo is not known. In the current study, resistance trained men (≥1 year) received dietary supplementation with 1...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29407798/environmentally-realistic-concentration-of-cadmium-combined-with-polyunsaturated-fatty-acids-enriched-diets-modulated-non-specific-immunity-in-rainbow-trout
#11
Valérie Cornet, Abderrahim Ouaach, S N M Mandiki, Enora Flamion, Aline Ferain, Mélusine Van Larebeke, Benjamin Lemaire, Felipe E Reyes López, Lluis Tort, Yvan Larondelle, Patrick Kestemont
Nutrition is crucial to grow healthy fish particularly in a context of pollution, overcrowding and pathogen risks. Nowadays, the search for food components able to improve fish health is increasingly developing. Here, the influence of four dietary polyunsaturated fatty acids (PUFAs) that are alpha-linolenic acid (ALA, 18:3n-3), linoleic acid (LA, 18:2n-6), eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) on the sensitivity of rainbow trout (Oncorhynchus mykiss) juveniles to environmentally realistic cadmium (Cd, 0...
February 1, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29393106/circulating-polyunsaturated-fatty-acids-as-biomarkers-for-dietary-intake-across-subgroups-the-codam-and-hoorn-studies
#12
Anne J Wanders, Marjan Alssema, Sabine E M De Hoon, Edith J M Feskens, Geertruida J van Woudenbergh, Carla J van der Kallen, Peter L Zock, Helga Refsum, Christian A Drevon, Amany Elshorbagy, Casper G Schalkwijk, Coen D A Stehouwer, Jacqueline M Dekker, Marleen M J van Greevenbroek
AIMS: To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). METHODS: Cross-sectional analyses were performed in pooled data from the CODAM (n = 469) and Hoorn (n = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (µg/mL)...
January 25, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29387383/nutritional-physicochemical-and-functional-properties-of-protein-concentrate-and-isolate-of-newly-developed-bambara-groundnut-vigna-subterrenea-l-cultivars
#13
Olaposi R Adeleke, Oladipupo Q Adiamo, Olumide S Fawale
Bambara groundnut is an indigenous African vegetable grown mainly for human food and animal feed due to its high protein content. Different factors like varieties and origin can influence the chemical composition of Bambara groundnut cultivars. Therefore, the aims of this study are to produce defatted flour and protein concentrate from newly developed Bambara groundnut cultivars [Accessions No: TVSU 5 - Bambara Groundnut White (BGW) and TVSU 146 - Bambara Groundnut Brown (BGB)] and compare their nutritional, physicochemical, and functional properties with market sample [Bambara groundnut commercial (BGC)]...
January 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29331744/urinary-metabolomics-study-the-mechanism-of-taohong-siwu-decoction-intervention-in-acute-blood-stasis-model-rats-based-on-liquid-chromatography-coupled-to-quadrupole-time-of-flight-mass-spectrometry
#14
Xiaosong Zhang, Pengling Li, Yongli Hua, Peng Ji, Wanling Yao, Qi Ma, Ziwen Yuan, Yanqiao Wen, Chaoxue Yang, Yanming Wei
Taohong Siwu Decoction (TSD) is a classic prescription in traditional Chinese medicine and is widely used to promote blood circulation to remove blood stasis. However, the effect mechanisms are not yet well understood. Here, a urinary metabolomic approach based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (LC/Q-TOF-MS) was conducted to explore the changes in the endogenous metabolites and to assess the integral efficacy of TSD on acute blood stasis model rats. Then, parameters for hemorheology and coagulation functions were detected...
February 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29315663/circulating-25-hydroxyvitamin-d-nasopharyngeal-airway-metabolome-and-bronchiolitis-severity
#15
K Hasegawa, C J Stewart, J C Celedón, J M Mansbach, C Tierney, C A Camargo
Low circulating 25-hydroxyvitamin D (25OHD) levels are a risk factor for acute respiratory infection (eg, bronchiolitis) in children. However, little is known about the relation of circulating 25OHD with the many downstream functional molecules in target organs-such as the airway-and with clinical outcomes. In this prospective multicenter study of infants (age <1 year) hospitalized with bronchiolitis, we measured serum 25OHD levels and profiled the metabolome of 144 nasopharyngeal airway samples. Among 254 metabolites identified, we defined a set of 20 metabolites that are related to lower serum 25OHD and higher vitamin D-binding protein levels...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29304057/long-chain-omega-3-polyunsaturated-fatty-acid-dietary-intake-is-positively-associated-with-bone-mineral-density-in-normal-and-osteopenic-spanish-women
#16
Jesus Lavado-García, Raul Roncero-Martin, Jose M Moran, Maria Pedrera-Canal, Ignacio Aliaga, Olga Leal-Hernandez, Sergio Rico-Martin, Maria L Canal-Macias
The regular consumption of long-chain omega-3 polyunsaturated fatty acids (LCO3-PUFAs) results in general health benefits. The intake of LCO3-PUFAs has been reported to contribute to bone metabolism. We aimed to investigate the relationships between dietary intakes of LCO3-PUFAs and bone mineral density (BMD) in Spanish women aged 20-79 years old. A total of 1865 female subjects (20-79 years old) were enrolled, and lumbar (L2, L3, L3 and total spine), hip (femoral neck (FN), femoral trochanter (FT) and Ward's triangle (WT)) bone mineral density (BMD) were measured by dual energy X-ray absorptiometry (DXA)...
2018: PloS One
https://www.readbyqxmd.com/read/29288354/functional-characterization-and-substrate-specificity-analysis-of-%C3%AE-6-desaturase-from-marine-microalga-isochrysis-sp
#17
S Thiyagarajan, M Arumugam, N Senthil, S Vellaikumar, S Kathiresan
OBJECTIVES: To express a Δ6-desaturase gene and produce gamma-linolenic acid (GLA) and stearidonic acid (SDA) in prokaryotic expression system (Escherichia coli), and analyze its substrate specificity in the omega-3 fatty acid biosynthetic pathway. RESULTS: Full-length ORF (1448 bp) of Δ6Des-Iso was isolated from Isochrysis sp. and characterized using multiple sequence alignment, phylogenetic analysis, transmembrane domain, and protein tertiary structure. Δ6Des-Iso is a front-end desaturase consisting of three conserved histidine domains and a cytochrome b5 domain...
March 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/29204449/combined-transcriptomic-analysis-revealed-akr1b10-played-an-important-role-in-psoriasis-through-the-dysregulated-lipid-pathway-and-overproliferation-of-keratinocyte
#18
Yunlu Gao, Xuemei Yi, Yangfeng Ding
RNA-seq has enabled in-depth analysis of the pathogenesis of psoriasis on the transcriptomic level, and many biomarkers have been discovered to be related to the immune response, lipid metabolism, and keratinocyte proliferation. However, few studies have combined analysis from various datasets. In this study, we integrated different psoriasis RNA-seq datasets to reveal the pathogenesis of psoriasis through the analysis of differentially expressed genes (DEGs), pathway analysis, and functional annotation. The revealed biomarkers were further validated through proliferation phenotypes...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29146138/development-of-kidney-transplant-fibrosis-is-inversely-associated-with-plasma-marine-fatty-acid-level
#19
Ivar A Eide, Christina Dörje, My Svensson, Trond Jenssen, Clara Hammarstrøm, Helge Scott, Kristian S Bjerve, Jeppe H Christensen, Erik B Schmidt, Anders Hartmann, Anders Åsberg, Anna V Reisæter, Finn P Reinholt
OBJECTIVE(S): We assessed associations between plasma levels of polyunsaturated fatty acids (PUFAs) and degree of inflammation and interstitial fibrosis in transplanted kidneys. DESIGN: The design of the study was single center cohort study. SUBJECTS: A study population of 156 patients who received a kidney transplant at Oslo University Hospital during 2010. MAIN OUTCOME MEASURE: Kidney transplant biopsies were obtained at 2 months and 1 year after transplantation...
November 14, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29080057/sex-differences-in-blood-hdl-c-the-total-cholesterol-hdl-c-ratio-and-palmitoleic-acid-are-not-associated-with-variants-in-common-candidate-genes
#20
Shannon L Klingel, Kaitlin Roke, Bertha Hidalgo, Stella Aslibekyan, Robert J Straka, Ping An, Michael A Province, Paul N Hopkins, Donna K Arnett, Jose M Ordovas, Chao-Qiang Lai, David M Mutch
Blood lipids are associated with cardiovascular disease (CVD) risk. Moreover, circulating lipid and fatty acid levels vary between men and women, and evidence demonstrates these traits may be influenced by single nucleotide polymorphisms (SNP). Sex-genotype interactions related to blood lipids and fatty acids have been poorly investigated and may help elucidate sex differences in CVD risk. The goal of this study was to investigate if the influence of SNPs previously associated with blood lipids and fatty acids varies in a sex-specific manner...
December 2017: Lipids
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