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https://www.readbyqxmd.com/read/29213024/-a-refractory-case-of-ulcerative-colitis-developed-after-the-cessation-smoking-achieved-clinical-and-endoscopic-remission-after-resuming-smoking
#1
Tetsuro Hamamoto, Masashi Ohtani, Eiji Matsumoto, Tatsuaki Hori, Ichiro Tsuruhara, Kazuo Yashima, Hajime Isomoto
A 42-year-old man, who had stopped smoking almost one year ago, visited our hospital for hematochezia. He was diagnosed as having ulcerative colitis and was prescribed 5-amino salicylic acid and corticosteroids, which led to the remission of his disease. However, the disease relapsed after sufficient continuous corticosteroids administration and persisted despite 5-amino salicylic acid administration and intensive treatment with corticosteroids, immune modulators, leukocyte apheresis, and anti-TNF-α antibodies...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29210068/optimal-storage-conditions-for-apheresis-research-oscar-a-biomedical-excellence-for-safer-transfusion-best-collaborative-study
#2
Thomas J Gniadek, Henk S P Garritsen, David Stroncek, Zbigniew M Szczepiorkowski, David H McKenna
BACKGROUND: Cell therapy products are often stored and transported between sites. The aim of this study was to determine the effect of storage temperature, solution, and cell concentration on nonmobilized, peripheral blood-derived mononuclear cells (MNCs). STUDY DESIGN AND METHODS: This was a multicenter prospective study involving healthy volunteers who underwent nonmobilized MNC collection by apheresis. Products were processed at local laboratories and concentrated to either 100 × 106 or 300 × 106 nucleated cells/mL in 5% human serum albumin (HSA) or HypoThermosol FRS (HT; BioLife Solutions)...
December 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29207227/first-case-report-of-using-ofatumumab-in-kidney-transplantation-ab0-incompatible
#3
Nicoletta Mancianti, Giulio Monaci, Fabio Rollo, Paola Buracchi, Andrea Guarnieri, Marina Di Luca, Mauro Martello, Guido Garosi
Modern methods for desensitization protocol rely heavily on combined apheresis therapy and Rituximab, a chimeric (murine and human) anti-CD20 antibody used in AB0 incompatible kidney transplants. Severe infusion related reactions due to the administration of Rituximab are reported in 10% of patients. These adverse reactions may hinder the completion of the desensitization protocol. Therefore, it's useful to test alternative B cell depleting therapies. Our clinical case focuses on a 41-year-old male who developed an adverse infusion reaction following the administration of Rituximab and was given Ofatumumab as an alternative treatment...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29205889/upcoming-meetings-therapeutic-apheresis-and-dialysis-december-2017
#4
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29192644/automated-centrifugal-therapeutic-plasma-exchange-option-for-guillain-barre-syndrome-a-report-from-calabar-nigeria
#5
O E Iheanacho, C Chimeziem, B S Sachais, P A Shi
Therapeutic plasma exchange (TPE) is performed frequently and effectively in developed countries, whereas the reverse is the case in developing countries. Guillain-Barre syndrome (GBS), synonymous with acute inflammatory demyelinating polyneuropathy, is an important indication for TPE, but this is rarely administered in the treatment of such patients in Nigeria due to lack of such automated facility, limited expertise, and high cost. This report therefore presents an uncommon case of GBS in which automated TPE was utilized in the management, with the aims of highlighting the current status and challenges of therapeutic apheresis services in Nigeria...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29191663/the-impact-of-single-dose-plerixafor-as-an-adjunct-to-g-csf-based-peripheral-blood-stem-cell-mobilisation-on-the-graft-composition-and-outcome-for-t-replete-haploidentical-pbsc-transplantation-with-post-transplantation-cyclophosphamide-a-comparative-study
#6
Sarita Rani Jaiswal, Prakash Bhakuni, Aby Joy, Nisha Murli, Priyanka Bharadwaj, Shamsur Zaman, Nedunchezian Murugayan, Suparno Chakrabarti
We conducted a prospective study on T and NK cell subset composition of the graft and the transplant outcomes inT-replete haploidentical transplantationwithsingle dose of subcutaneous Plerixafor(Px)added to G-CSF based mobilisation in allogeneic donors to collect 10 x 106/kg CD34+HSC at single apheresis. 26 donors received G-CSF+Px and 25 donors received G-CSF alone for mobilisation. Despite a significantly lower peripheral blood (PB) CD34+HSC on day 4 in the G-CSF+Px group [33(6-47) cells/µl vs 81(50-168) cells/µl in G-CSF group, p=0...
November 27, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29176657/dyslipidaemia-in-nephrotic-syndrome-mechanisms-and-treatment
#7
REVIEW
Shipra Agrawal, Joshua J Zaritsky, Alessia Fornoni, William E Smoyer
Nephrotic syndrome is a highly prevalent disease that is associated with high morbidity despite notable advances in its treatment. Many of the complications of nephrotic syndrome, including the increased risk of atherosclerosis and thromboembolism, can be linked to dysregulated lipid metabolism and dyslipidaemia. These abnormalities include elevated plasma levels of cholesterol, triglycerides and the apolipoprotein B-containing lipoproteins VLDL and IDL; decreased lipoprotein lipase activity in the endothelium, muscle and adipose tissues; decreased hepatic lipase activity; and increased levels of the enzyme PCSK9...
November 27, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29174797/the-american-society-for-apheresis-asfa-disease-registry-past-present-and-future
#8
REVIEW
Edward C C Wong, Jennifer Webb, Monica B Pagano
No abstract text is available yet for this article.
November 21, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29169683/leukapheresis-in-15-patients-weighing-20kg-or-less-a-single-centre-experience
#9
Feng Zeng, HaoBo Huang, DanHui Fu, QingHua Huang, LiPing Fan, ShiJing Wei
The application of apheresis equipment to perform leukapheresis (LK) in low weight paediatric patients is logistically complex and lacking of largest clinical performing experiences, meanwhile, the benefit from LK is controversial. In this study, 15 children with acute lymphoblastic leukemia(ALL)and acute myeloid leukemia (AML) and hyperleukocytosis were treated with the COBE Spectra apheresis system in the general paediatric ward by the staff from the department of Blood Transfusion. 26 LK procedures were performed...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29168461/study-of-stem-cell-homing-self-renewal-marker-gene-profile-of-ex-vivo-expanded-human-cd34-cells-manipulated-with-a-mixture-of-cytokines-stromal-cell-derived-factor-1
#10
Jyoti Kode, Navin Khattry, Ashish Bakshi, Vasanti Amrutkar, Bhausaheb Bagal, Rohini Karandikar, Pallavi Rane, Nobutaka Fujii, Shubhada Chiplunkar
BACKGROUND & OBJECTIVES: Next generation transplantation medicine aims to develop stimulating cocktail for increased ex vivo expansion of primitive hematopoietic stem and progenitor cells (HSPC). The present study was done to evaluate the cocktail GF (Thrombopoietin + Stem Cell factor + Flt3-ligand) and homing-defining molecule Stromal cell-derived factor 1 (SDF1) for HSPC ex vivo expansion. METHODS: Peripheral blood stem cell (n=74) harvests were analysed for CD34hiCD45lo HSPC...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29162402/peripheral-blood-stem-cell-collection-for-allogeneic-hematopoietic-stem-cell-transplantation-practical-implications-after-200-consequent-transplants
#11
Deniz Goren Sahin, Mutlu Arat
BACKGROUND: Proper stem cell mobilization is one of the most important steps in hematopoietic stem cell transplantation (HSCT). The aim of this paper is to share our 6 years' experience and provide practical clinical approaches particularly for stem cell mobilization and collection within the series of more than 200 successive allogeneic HSCT at our transplant center. SUBJECTS & METHODS: Two hundred and seven consecutive patients who underwent allogeneic peripheral blood stem cell transplantation were included in this study...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162401/risk-factors-for-poor-mobilization-in-solid-tumors-how-effectively-can-we-mobilize-patients-with-solid-tumors
#12
REVIEW
Fergun Yilmaz, Nur Soyer, Ruchan Uslu, Mahmut Tobu, Burcak Karaca, Guray Saydam, Fahri Sahin, Filiz Vural
BACKGROUND: In the literature, risk factors for poor mobilization were tried to identify. However, most of the studies consisted heterogeneous group of patients including both hematologic and oncologic malignancies. In this study, we aimed to identify the risk factors for poor mobilization in adults with solid tumors. METHODS: We enrolled 49(47 men, 2 women) adult patients with solid tumor who were mobilized between September 2007 and February 2017. All the mobilization procedures were performed with G-CSF(10μg/kg/day) with chemotherapy...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162400/an-alternative-method-for-custom-prime-a-case-report-of-successful-peripheral-blood-stem-cell-harvesting-from-two-low-weight-child-donors
#13
Ashraf Malek Mohammadi, Amir Hossein Norooznezhad, Parivash Aminian, Mohsen Nikbakht, Bahram Chahardouli, Shahrbano Rostami, Farhad Heshmati, Saeed Mohammadi, Ardeshir Ghavamzadeh
Allogeneic peripheral blood stem cell (APBSCs) transplantation is an effective treatment for hematological malignancies. However low-weight donor children meet some complications. In the current report, PBSCs were harvested from a 14-month-old child (9.8Kg) for a 6years old sibling recipient suffering from pre-B type of acute lymphoblastic leukemia (ALL) and also 24 months old male child donor (12Kg) for a haploidentical recipient suffering from acute myeloid leukemia (AML-M4EO). The PBSC harvesting was performed using Spectra™ Optia(®) apheresis software with continuous mononuclear cell (CMNC) procedure...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162397/biosimilar-filgrastim-leucostim%C3%A2-have-similar-efficacy-in-steady-state-hematopoietic-progenitor-cell-mobilization-compared-to-original-filgrastim-neupogen%C3%A2-and-lenograstim-granocyte%C3%A2-a-retrospective-multicenter-study
#14
Ömür Kayıkçı, Emre Tekgündüz, Ali Hakan Kaya, Hakan Göker, Alma Aslan, Dicle İskender, Sinem Namdaroglu, Aysegul Tetik, Şerife Koçubaba, Fevzi Altuntaş
Biosimilar filgrastim (Leucostim(®)) was shown to be similar in terms of efficacy and safety in hematopoietic progenitor cell mobilization (HPCM) compared to originator filgrastim (Neupogen(®)) and lenograstim (Granocyte(®)) in healthy donors and chemomobilization settings. Here we report our retrospective experience with Leucostim(®) (n: 43) compared to Neupogen(®) (n: 71) and Granocyte(®) (n: 32) in steady-state mobilization of patients presenting with Hodgkin lymphoma, non-Hodgkin lymphoma and multiple myeloma...
November 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162396/factors-associated-with-peripheral-blood-stem-cell-yield-in-healthy-pediatric-donors
#15
REVIEW
Gülsün Karasu, Vedat Uygun, Akif Yesilipek
BACKGROUND AND OBJECTIVES: Although several studies have reported on the use of children as donors for peripheral blood stem cells (PBSC), data on the predictive factors of CD34+ stem cell yield in healthy pediatric donors are very limited. DESIGN AND METHOD: We retrospectively analyzed factors predicting the yield for a target CD34 cell dose of >3×106/kg recipient body weight in 140 apheresis in 100 healthy pediatric donors. The donors were evaluated in four groups assigned according to their ages of being 0-4 years, 5-9 years, 10-14 years and 15-18 years...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162394/what-is-the-role-of-apheresis-technology-in-stem-cell-transplantation
#16
REVIEW
Ilhami Kiki
Since the demonstration that hematopoietic cells are present in circulating blood, peripheral blood stem cell transplantation (PBSCT) has become an area of interest. The invention of growth factors such as the granulocyte colony-stimulating factor (G-CSF) and the availability of apheresis techniques allowed the wide application of peripheral blood stem cells (PBSC) in both autologous and allogeneic hematopoietic stem cell transplantation settings. It has been since 1986 that clinically introduced, peripheral blood stem cells replaced bone marrow as a stem-cell source to nearly 100% in the autologous and to approximately 75% in the allogeneic transplantation setting...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29153349/world-apheresis-association-member-society-updates
#17
EDITORIAL
Jean O'Brien-Louis
No abstract text is available yet for this article.
November 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29153306/autologous-hematopoietic-progenitor-cell-mobilization-and-collection-in-adult-patients-presenting-with-multiple-myeloma-and-lymphoma-a-position-statement-from-the-turkish-society-of-apheresis-tsa
#18
REVIEW
Emre Tekgündüz, Mutlu Arat, Hakan Göker, Hakan Özdoğu, Leylagül Kaynar, Seçkin Çağırgan, Mehmet Ali Erkurt, Filiz Vural, İlhami Kiki, Fevzi Altuntaş, Fatih Demirkan
Autologous hematopoietic cell transplantation (AHCT) is a routinely used procedure in the treatment of adult patients presenting with multiple myeloma (MM), Hodgkin lymphoma (HL) and various subtypes of non-Hodgkin lymphoma (NHL) in upfront and relapsed/refractory settings. Successful hematopoietic progenitor cell mobilization (HPCM) and collection are the rate limiting first steps for application of AHCT. In 2015, almost 1700 AHCT procedures have been performed for MM, HL and NHL in Turkey. Although there are recently published consensus guidelines addressing critical issues regarding autologous HPCM, there is a tremendous heterogeneity in terms of mobilization strategies of transplant centers across the world...
November 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29150875/treatment-of-acquired-thrombotic-thrombocytopenic-purpura-in-the-u-s-remains-heterogeneous-current-and-future-points-of-clinical-equipoise
#19
Marshall A Mazepa, Jay S Raval, Mark E Brecher, Yara A Park
BACKGROUND: The purpose of this survey was to describe current practices in the U.S. for treatment of acquired Thrombotic Thrombocytopenic Purpura (TTP), compare these with prior U.S. and current Canadian practices, and identify areas of clinical equipoise. STUDY DESIGN AND METHODS: A research team member administered the survey by telephone. Questions included an estimate of the annual patient volume treated, apheresis and medical therapy practices for acquired TTP...
November 18, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29150864/seeing-is-believing-a-review-of-apheresis-therapy-in-the-treatment-of-ophthalmologic-disease
#20
Brendan C Graham, Jose S Pulido, Jeffrey L Winters
Apheresis procedures have a role in treatment of disparate diseases involving many different organ systems. Often the disease processes where apheresis plays a role in treatment are considered "orphan diseases"-relatively rare disease processes that lack specific pharmaceutical agents or established treatment protocols. Many of these disease processes can affect the eye with devastating results for the eyesight of these patients. The unique ability of apheresis to affect disease by modifying blood plasma and modulating disease-causing agents therein renders apheresis procedures valuable tools in the treatment of certain ophthalmologic diseases...
November 18, 2017: Journal of Clinical Apheresis
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