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https://www.readbyqxmd.com/read/29668550/pediatric-chronic-myeloid-leukemia-presenting-with-extreme-thrombocytosis-simulating-essential-thrombocythemia
#1
Jessica L Boklan, Alexandra M Walsh, Michelina C de la Maza, Leon L Su, Francisco A Nizzi, Kristian T Schafernak
A 10-year-old boy presented with spontaneous bruising and was found to have extreme thrombocytosis without neutrophilia/shift to immaturity, basophilia or eosinophilia. While the peripheral blood and bone marrow findings initially suggested essential thrombocythemia, BCR-ABL1 translocation was detected and chronic myeloid leukemia, chronic phase, was diagnosed. Apheresis for platelet depletion was performed as a bridge given the delayed effects of medical therapy.
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29664170/bacterial-screening-of-apheresis-platelets-with-a-rapid-test-a-113-month-single-center-experience
#2
Kristen N Ruby, Reggie R Thomasson, Zbigniew M Szczepiorkowski, Nancy M Dunbar
BACKGROUND: The 2016 Food and Drug Administration draft guidance describes the use of a rapid test (RT) to enhance platelet transfusion safety and availability. This study reports a 113-month experience of screening of apheresis platelets (APs) by RT. STUDY DESIGN AND METHODS: From July 2008 to October 2015, all APs underwent an RT on Day 4. Day 6 and 7 units were transfused with transfusion medicine physician approval. Any units remaining on Day 8 had a second RT performed...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29657872/therapeutic-plasma-exchange-for-refractory-sle-a-comparison-of-outcomes-between-different-sub-phenotypes
#3
Aynur Soyuöz, Ömer Karadağ, Tülay Karaağaç, Levent Kılıç, Şule Apraş Bilgen, Osman İlhami Özcebe
Objective: Therapeutic plasma exchange (TPE) offers an alternative therapeutic modality for patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). However, there is conflicting evidence regarding its efficacy in different sub-phenotypes. This study aimed to investigate the main clinical characteristics and outcomes of patients with different phenotypes of SLE and APS treated with TPE at a tertiary care center. Methods: The database of the Blood and Apheresis Unit between 2001 and 2013 was screened for patients with SLE and primary APS...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29656457/late-sampling-for-automated-culture-to-extend-the-platelet-shelf-life-to-5-days-in-germany
#4
Tanja Vollmer, Mareike Dabisch-Ruthe, Melanie Weinstock, Cornelius Knabbe, Jens Dreier
BACKGROUND: Bacterial contamination of platelet concentrates (PCs) is still a major challenge in transfusion medicine. Different methodologic concepts and screening strategies have been developed and investigated concerning their usability. We evaluated the feasibility of BacT/ALERT automated culture (BacT/A, bioMérieux) with late sampling after 3 days at the earliest. STUDY DESIGN AND METHODS: Twenty-four bacterial strains isolated from PCs and six relevant strains from reference stocks were spiked into apheresis-derived PCs (10-60 colony-forming units [CFU]/bag)...
April 15, 2018: Transfusion
https://www.readbyqxmd.com/read/29645288/special-issue-abstracts-from-the-american-society-for-apheresis-39-th-annual-meeting-april-25-28-2018-chicago-illinois
#5
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29644730/in-vitro-quality-of-apheresis-platelets-divided-into-paediatric-sized-units-and-stored-in-pvc-bags-plasticised-with-totm-bthc-or-dinch
#6
S Bashir, A Meli, R Cardigan
BACKGROUND AND OBJECTIVES: Two of the predictive factors of the quality of small volumes of platelets suitable for paediatric use are bag size and material. This study evaluated the storage properties of paediatric platelet aliquots in TOTM-, BTHC- or DINCH-PVC bags. METHODS/MATERIALS: (i) Three apheresis platelet concentrates (PC) were pooled and split into three units. One was retained as an adult unit (control; polyolefin bag). The second and third units were split into four MacoPharma TOTM-PVC and BTHC-PVC paediatric bags, respectively...
April 11, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29607515/implementation-of-secondary-bacterial-culture-testing-of-platelets-to-mitigate-residual-risk-of-septic-transfusion-reactions
#7
Evan M Bloch, Christi E Marshall, Joan S Boyd, Lisa Shifflett, Aaron A R Tobian, Eric A Gehrie, Paul M Ness
BACKGROUND: Bacterial contamination of platelets remains a major transfusion-associated risk despite long-standing safety measures in the United States. We evaluated an approach using secondary bacterial culture (SBC) to contend with residual risk of bacterial contamination. STUDY DESIGN AND METHODS: Phased implementation of SBC was initiated in October 2016 for platelets (all apheresis collected) received at our institution from the blood donor center (Day 3 post collection)...
April 1, 2018: Transfusion
https://www.readbyqxmd.com/read/29604163/multicenter-in-vitro-thromboelastography-and-thromboelastometry-standardization
#8
Robert Goggs, Antonio Borrelli, Benjamin M Brainard, Daniel L Chan, Armelle de Laforcade, Isabelle Goy-Thollot, Karl E Jandrey, Annemarie T Kristensen, Annette Kutter, Clara B Marschner, Benoît Rannou, Nadja Sigrist, Catherine Wagg
OBJECTIVE: To establish and compare the repeatability and reproducibility of activated thromboelastography (TEG) and thromboelastometry (ROTEM) assays. DESIGN: Multicenter in vitro test standardization. SETTING: Veterinary academic centers. ANIMALS: Test samples were obtained from normal, healthy dogs. Sixty identical 5 mL aliquots of canine platelet-rich plasma collected by apheresis, frozen in 6% dimethyl sulfoxide, were tested initially...
March 31, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29603795/optia%C3%A2-continuous-mononuclear-collection-cmnc-system-is-a-safe-and-efficient-system-for-hematopoietic-progenitor-cells-apheresis-hpc-a-collection-and-yields-a-lower-product-hematocrit-hct-than-the-cobe%C3%A2-spectra-system-a-retrospective-study
#9
Soumya Pandey, Michele Cottler-Fox
PURPOSE: We evaluated the Optia® continuous mononuclear collection (CMNC) system for hematopoietic progenitor cell-apheresis (HPC-A) collection (Terumo BCT, Lakewood, CO) compared to the COBE® Spectra (Terumo BCT, Lakewood, CO), including both large volume leukapheresis (LVL) and non-LVL collections. METHODS: We performed a retrospective data analysis of all autologous HPC-A collections with the Optia® CMNC system (n = 93; LVL = 59, non-LVL = 34) since implementation at our institution and compared it with a similar number of concurrent collections utilizing the COBE® Spectra (n = 96; LVL = 68, non-LVL = 28)...
March 30, 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29603238/cold-storage-of-platelets-in-platelet-additive-solution-an-in-vitro-comparison-of-two-food-and-drug-administration-approved-collection-and-storage-systems
#10
Kristin M Reddoch-Cardenas, Robbie K Montgomery, Crystal B Lafleur, Grantham C Peltier, James A Bynum, Andrew P Cap
BACKGROUND: Refrigeration of platelets (PLTs) in a PLT additive solution (PAS) reduces PLT activation compared to storage in plasma and preserves function for at least 15 days. Currently only two PASs are licensed by the Food and Drug Administration, each for use with only one apheresis platform. In this study, we compared the metabolic, functional, and activation status of PLTs collected on a Trima apheresis collection system and stored refrigerated in Isoplate (ISO) PAS to PLTs collected on an Amicus collection system and stored refrigerated in Intersol (INT) PAS...
March 30, 2018: Transfusion
https://www.readbyqxmd.com/read/29593456/robust-production-of-cytomegalovirus-pp65-specific-t-cells-using-a-fully-automated-ifn-%C3%AE-cytokine-capture-system
#11
Nayoun Kim, Young-Sun Nam, Keon-Il Im, Jung-Yeon Lim, Young-Woo Jeon, Yunejin Song, Jong Wook Lee, Seok-Goo Cho
Background: Cytomegalovirus(CMV)-related diseases are a serious cause of morbidity and mortality following hematopoietic stem cell transplantation (HSCT). CMV-specific cytotoxic T lymphocytes (CMV-CTLs) have been reported as an alternative to antiviral drugs that provide long-term CMV-specific immunity without major side effects. However, their application has been limited by the prolonged manufacturing process required. Methods: In this study, we applied the IFN-γ cytokine capture system (CCS) using the fully automated CliniMACS Prodigy device for rapid production of CMV-CTLs, which may be applicable in clinically urgent CMV-related diseases...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29589657/-extracorporeal-photopheresis
#12
Aurélie Hsieh, Begonia Cortés
During the treatment of extracorporeal photopheresis (ECP), white blood cells are collected by apheresis and exposed to ultraviolet A after incubation with 8-methoxypsoralen. Although ECP was first developed for cutaneous T cell lymphoma, it has shown promising efficacy in a number of other serious conditions, like acute and chronic graft-versus-host disease, lung and cardiac transplant rejection and other autoimmune diseases. The ECP has been used for thirty years in some specialized centers but remains unknown to most of the physicians...
March 28, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29577764/-immunoadsorption-in-a-patient-with-dilated-cardiomyopathy-the-first-case-in-hungary
#13
Pál Soltész, Melinda Vass, Ágnes Diószegi, Ivetta Mányiné Siket, Ildikó Garai, Csaba Kun, Orsolya Bene, Attila Kertész, István Édes
Dilated cardiomyopathy is the main cause of heart transplantation. The etiology is unknown in almost half of the cases. Many cardiac specific antibodies have been identified till now which can cause decreased cardiac function, ventricular tachycardia or sudden heart death. The prognosis of DCM is poor despite the development of medical treatment. Immunoadsorption is hopeful since, with the removal of antibodies, cardiac function and NYHA class can improve and LVAD/heart transplantation-free survival can be prolonged...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29576502/the-healthy-donor-profile-of-immunoregulatory-soluble-mediators-is-altered-by-stem-cell-mobilization-and-apheresis
#14
Guro Kristin Melve, Elisabeth Ersvaer, Kristin Paulsen Rye, Aymen Bushra Ahmed, Einar K Kristoffersen, Tor Hervig, Håkon Reikvam, Kimberley Joanne Hatfield, Øystein Bruserud
BACKGROUND: Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and thereafter harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. METHODS: Plasma levels of 38 soluble mediators (cytokines, soluble adhesion molecules, proteases, protease inhibitors) were analyzed in samples derived from healthy stem cell donors before G-CSF treatment and after 4 days, both immediately before and after leukapheresis...
March 22, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29575114/american-council-on-ecp-ace-why-now
#15
Richard Edelson, Yanyun Wu, Jennifer Schneiderman
Stimulated by the scientific progress in deciphering the principal elements contributing to the clinical efficacy of extracorporeal photochemotherapy (ECP), the American Council on ECP (ACE) was formed, under the auspices of the American Society for Apheresis (ASFA), to develop a field-guiding Consensus Report. ACE is composed of thirty nationally recognized ECP experts, clinically spanning cancer, transplantation, and autoimmunity and scientifically bridging immunology, bioengineering, and hematology. The two-day meeting took place in Manhattan, April 13-14, 2017, and unanimous consensus on nine pivotal points is herein reported...
March 25, 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29575062/restored-response-to-adp-downstream-of-purinergic-p2y-12-receptor-in-apheresis-platelets-after-pathogen-reducing-xenon-flash-treatment
#16
Hideki Abe, Takaaki Abe, Masayuki Shiba, Masahiro Satake
BACKGROUND: Our previous study revealed that pathogen-reducing filtered xenon flash-treated platelets (fXe-PLTs) showed sustained aggregation in response to adenosine diphosphate (ADP), but apheresis-collected PLTs (Aph-PLTs) showed reversible aggregation. STUDY DESIGN AND METHODS: Aph-PLTs, fXe-PLTs, and freshly prepared PLTs (PRP-PLTs) from whole blood were used to investigate the following responses to ADP: concentration response and effects of ADP receptor antagonists on aggregation, the cytosolic calcium (Ca2+ ) flux downstream of P2Y1 receptor signaling, and phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and signaling intermediate protein Akt downstream of the P2Y12 receptor...
March 25, 2018: Transfusion
https://www.readbyqxmd.com/read/29572917/the-effects-of-galectin-3-depletion-apheresis-on-induced-skin-inflammation-in-a-porcine-model
#17
Nalu Navarro-Alvarez, Beatriz Goncalves, Alec R Andrews, Zhaohui Wang, Zhirui Wang, Edward Harrington, Jigesh Shah, David H Sachs, Isaac Eliaz, Christene A Huang
Galectin-3 (Gal-3), a β-galactoside-binding lectin that is expressed in mammalian cells, is known to modulate several biological functions such as cell-cell adhesion, macrophage activation, angiogenesis, metastasis, and fibrosis. The goal of this study was to evaluate the ability of Gal-3 depletion apheresis using an adsorption column with immobilized anti-Gal-3-antibody to reduce inflammation induced by Complete Freund's Adjuvant injection in a skin inflammation porcine model. Here, we report that plasma perfusion by apheresis through a Gal-3 binding immuno-affinity column reduces plasma Gal-3 levels to below limits of quantitative detection, and results in significant decrease in skin inflammation, including degree and duration of inflammatory lesions...
March 23, 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29572391/infusion-of-donor-derived-cd8-memory-t-cells-for-relapse-following-allogeneic-hematopoietic-cell-transplantation
#18
Lori Muffly, Kevin Sheehan, Randall Armstrong, Kent Jensen, Keri Tate, Andrew R Rezvani, David Miklos, Sally Arai, Judith Shizuru, Laura Johnston, Everett Meyer, Wen-Kai Weng, Ginna G Laport, Robert S Negrin, Sam Strober, Robert Lowsky
Murine models showed that CD8+ CD44hi memory T (TM ) cells could eradicate malignant cells without inducing graft-versus-host disease (GVHD). We evaluated the feasibility and safety of infusing freshly isolated and purified donor-derived phenotypic CD8+ TM cells into adults with disease relapse after allogeneic hematopoietic cell transplantation (HCT). Phenotypic CD8 TM cells were isolated after unmobilized donor apheresis using a tandem immunomagnetic selection strategy of CD45RA depletion followed by CD8+ enrichment...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29570217/impact-of-apheresis-automation-on-procedure-quality-and-predictability-of-cd34-cell-yield
#19
Nelly Besson, Mie Topholm Bruun, Thomas Stauffer Larsen, Christian Nielsen
Success of peripheral blood stem cell (PBSC) collections depends on patient biological parameters and stable apheresis device performance. We investigated product quality and factors influencing main apheresis procedure outcomes including CD34+ collection efficiency (CE), product volume or platelet CE. We also assessed different CD34+ cell yield prediction algorithms. Autologous PBSC collections by Spectra Optia from myeloma and lymphoma patients were analyzed. Complete blood count (CBC) from patient preprocedure and from collected products were assessed...
March 23, 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29566772/platelet-lysate-as-a-novel-serum-free-media-supplement-for-the-culture-of-equine-bone-marrow-derived-mesenchymal-stem-cells
#20
Maria C Naskou, Scarlett M Sumner, Anna Chocallo, Hannah Kemelmakher, Merrilee Thoresen, Ian Copland, Jacques Galipeau, John F Peroni
BACKGROUND: Mesenchymal stem cells (MSCs) produced for clinical purposes rely on culture media containing fetal bovine serum (FBS) which is xenogeneic and has the potential to significantly alter the MSC phenotype, rendering these cells immunogenic. As a result of bovine-derived exogenous proteins expressed on the cell surface, MSCs may be recognized by the host immune system as non-self and be rejected. Platelet lysate (PL) may obviate some of these concerns and shows promising results in human medicine as a possible alternative to FBS...
March 22, 2018: Stem Cell Research & Therapy
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