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Apheresis

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https://www.readbyqxmd.com/read/29451308/apheresis-buffy-coat-collection-without-photoactivation-has-no-effect-on-apoptosis-cell-proliferation-and-total-viability-of-mononuclear-cells-collected-using-photopheresis-systems
#1
Zbigniew M Szczepiorkowski, Christine A Burnett, Larry J Dumont, Sunil H Abhyankar
BACKGROUND: Extracorporeal photopheresis (ECP) has been approved for the treatment of advanced cutaneous T-cell lymphoma since 1988. While the precise mechanisms resulting in clinical effects are not fully understood, the photoactivation of mononuclear cells (MNCs) using ultraviolet A (UVA) light and methoxsalen is believed to be the predominant initiating process. The effects of MNC passage through the instrument without photoactivation are unknown. The objective of this study was to evaluate the effect of cell processing through the photopheresis instruments on MNCs...
February 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29451147/perioperative-single-donor-platelet-apheresis-and-red-blood-cell-transfusion-impact-on-90-day-and-overall-survival-in-living-donor-liver-transplantation
#2
Wei Zheng, Kang-Mei Zhao, Li-Hui Luo, Yang Yu, Sheng-Mei Zhu
Background: Although many previous studies have confirmed that perioperative blood transfusion is associated with poor outcomes after liver transplantation (LT), few studies described the influence of single-donor platelet apheresis transfusion in living donor LT (LDLT). This study aimed to assess the effect of blood products on outcomes for LDLT recipients, focusing on apheresis platelets. Methods: This retrospective study included 126 recipients who underwent their first adult-to-adult LDLT...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29443413/vascular-access-for-therapeutic-plasma-exchange
#3
REVIEW
Tina S Ipe, Marisa B Marques
Therapeutic plasma exchange is an apheresis modality in which plasma is separated from the blood cellular components ex vivo, discarded, and replaced with an isosmotic fluid (most commonly 5% albumin) to maintain appropriate oncotic pressure in the patient. Therapeutic plasma exchange is used in the treatment of many diseases and indications. The recent seventh edition of the American Society for Apheresis guidelines indicates approximately 72 diseases and 116 indications for which therapeutic plasma exchange may be effective...
February 2018: Transfusion
https://www.readbyqxmd.com/read/29443410/a-tale-of-two-ports-an-in-vitro-comparison-of-flow-characteristics-for-therapeutic-plasma-exchange
#4
Nicole De Simone, Ravi Sarode
Tunneled central venous catheters with ports are increasingly used for therapeutic apheresis procedures. Vortex ports have been used as access for therapeutic apheresis procedures, but are not ideal for therapeutic plasma exchange (TPE) procedures due to lower flow rates. We performed an in vitro experiment to compare flow characteristics of the single-lumen Vortex port (AngioDynamics) with the single-lumen TidalPort (Norfolk Medical). We used expired red blood cell units and adjusted the hematocrit to 40% with normal saline in a 2-L bag...
February 2018: Transfusion
https://www.readbyqxmd.com/read/29443409/cellular-collection-by-apheresis
#5
REVIEW
Anand Padmanabhan
Cellular collection is an important and increasingly used apheresis procedure. These collections are performed by leukocytapheresis, a procedure involving the removal of a patient's or donor's white blood cells, and are used to collect hematopoietic progenitor cells, specific cell populations (such as T-lymphocytes), and granulocytes. Hematopoietic progenitor cell apheresis and T-lymphocyte collection are performed by procedures that enrich for mononuclear cells. Hematopoietic progenitor cells are used for autologous and allogeneic hematopoietic stem cell transplantation, whereas T-cell collection is being used increasingly in novel cellular therapy approaches and for donor lymphocyte infusions to induce graft-versus-leukemia effect...
February 2018: Transfusion
https://www.readbyqxmd.com/read/29440738/advantages-of-non-cryopreserved-autologous-hematopoietic-stem-cell-transplantation-against-a-cryopreserved-strategy
#6
M Sarmiento, P Ramírez, R Parody, M Q Salas, N Beffermann, V Jara, P Bertín, I Pizarro, C Lorca, E Rivera, M Galleguillos, M Ocqueteau, I Sánchez-Ortega, B Patiño, A Sureda
Autologous stem cell transplantation (auto-HSCT) is an effective treatment strategy for hematological malignancies. The standard mode of handling hematopoietic progenitors for the autologous procedure (CRYO) consists on its collection and freezing with dimethyl sulfoxide (DMSO) and its subsequent thawing and re-infusion. This process is toxic and expensive. Non-cryopreserved (non-CRYO) is a less expensive mode of auto-HSCT. We designed a comparative study between both strategies performed in two different centers to analyze the short-term complications...
February 13, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29439735/peripheral-mononuclear-blood-cell-apheresis-in-a-preclinical-ovine-model
#7
Helen Lydon, Roger Brooks, Andrew McCaskie, Frances Henson
BACKGROUND: Recent research has demonstrated that circulating peripheral blood mononuclear fractions (PBMC) containing haematopoietic stem (HSC)/progenitor cells have the potential to play a crucial role in regenerative medicine strategies. Work in our laboratory has shown that a peripheral blood mononuclear cell fraction (PBMC) enhances cartilage repair in an osteochondral defect model in sheep and has a significant effect on cells in the joint niche. In order to obtain PBMC rich blood containing HSCs for further studies, we have performed, for the first time, apheresis on adult sheep...
February 13, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29435110/transfusion-associated-adverse-reactions-taars-and-cytokine-accumulations-in-the-stored-blood-components-the-impact-of-prestorage-versus-poststorage-leukoreduction
#8
Chih-Chun Chang, Tai-Chen Lee, Ming-Jang Su, Hsiu-Chen Lin, Fang-Yi Cheng, Yi-Ting Chen, Tzung-Hai Yen, Fang-Yeh Chu
Leukoreduction in blood units could prevent patients undergoing transfusions from transfusion-associated adverse reactions (TAARs) such as febrile nonhemolytic transfusion reactions (FNHTRs). However, the effect of prestorage and poststorage leukoreduction on TAARs and its underlying mechanisms in stored blood components remains to be determined. Therefore, we investigated the impact of prestorage leukocyte-reduced (pre-LR) and poststorage leukocyte-reduced (post-LR) blood products, including red blood cells (RBCs) and apheresis platelets (PHs), on the incidence of FNHTRs and other TAARs in patients who received transfusions from 2009 to 2014 in a tertiary care center...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415907/guidance-for-pediatric-familial-hypercholesterolemia-2017
#9
Mariko Harada-Shiba, Takao Ohta, Akira Ohtake, Masatsune Ogura, Kazushige Dobashi, Atsushi Nohara, Shizuya Yamashita, Koutaro Yokote
This paper describes consensus statement by Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia (FH) in order to improve prognosis of FH.FH is a common genetic disease caused by mutations in genes related to low density lipoprotein (LDL) receptor pathway. Because patients with FH have high LDL cholesterol (LDL-C) levels from the birth, atherosclerosis begins and develops during childhood which determines the prognosis...
February 6, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29411399/twiddler-s-syndrome-in-an-adolescent-female-with-an-apheresis-port
#10
Alisa Fish, Margo R Rollins, Pam Langley, Mindy King, Cynthia Forney, Cassandra D Josephson, Ross M Fasano
No abstract text is available yet for this article.
February 2018: Transfusion
https://www.readbyqxmd.com/read/29408506/higher-donor-apheresis-blood-volumes-are-associated-with-a-reduction-in-relapse-risk-and-improved-survival-in-reduced-intensity-allogeneic-transplants-with-unrelated-donors
#11
Lisa M Crisalli, Joanne T Hinkle, Christopher C Walling, Mary Sell, Noelle V Frey, Elizabeth O Hexner, Alison W Loren, Selina M Luger, Edward A Stadtmauer, David L Porter, Ran Reshef
Allogeneic hematopoietic stem cell transplantation (HSCT) with reduced intensity conditioning (RIC) offers a curative option for patients with hematologic malignancies who are unable to undergo myeloablative conditioning, but its success is limited by high rates of relapse. Several studies have suggested a role for T-cell doses in peripheral blood stem-cell grafts in RIC HSCT. Since T-cell dose is typically not known until after the collection, and apheresis blood volume is easily modifiable, we hypothesized that higher donor apheresis blood volumes would improve transplant outcomes through an effect on graft composition...
February 2, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29407887/a-nation-wide-survey-of-patients-with-homozygous-familial-hypercholesterolemia-phenotype-undergoing-ldl-apheresis-in-turkey-a-hit-1-registry
#12
Meral Kayikcioglu, Lale Tokgozoglu, Mehmet Yilmaz, Leylagul Kaynar, Melih Aktan, Rana Berru Durmuş, Cumali Gokce, Ahmet Temizhan, Osman Ilhami Ozcebe, Tulay Karaagac Akyol, Harika Okutan, Saim Sag, Ozen Oz Gul, Zafer Salcioglu, Mustafa Yenercag, Bulent B Altunkeser, Irfan Kuku, Hamiyet Yilmaz Yasar, Erdal Kurtoglu, Melis Demir Kose, Sinan Demircioglu, Zafer Pekkolay, Osman Ilhan
BACKGROUND AND AIMS: Homozygous familial hypercholesterolemia (HoFH) is a genetic condition characterized by lethally high levels of low-density lipoprotein cholesterol (LDL-C) from birth, and requires rapid and aggressive intervention to prevent death due to coronary heart disease and/or atherosclerosis. Where available, lipoprotein apheresis (LA) is the mainstay of treatment to promote survival. METHODS: A-HIT1 registry was conducted with the aim of providing insight to the real-life management of HoFH patients undergoing LA in Turkey, where LA procedures are fully reimbursed and widely available...
January 29, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407885/high-serum-triglyceride-concentrations-in-patients-with-homozygous-familial-hypercholesterolemia-attenuate-the-efficacy-of-lipoprotein-apheresis-by-dextran-sulfate-adsorption
#13
Jean-Philippe Drouin-Chartier, André J Tremblay, Jean Bergeron, Benoît Lamarche, Patrick Couture
BACKGROUND AND AIMS: Maximizing the acute reduction of LDL-cholesterol (C) and lipoprotein (a) (Lp(a)) concentrations in patients with homozygous familial hypercholesterolemia (HoFH) is the main goal of lipoprotein apheresis (LA). The objective of this study was to examine how the pre-LA serum TG concentrations influence the efficacy of LA to acutely reduce LDL-C and Lp(a) concentrations in HoFH patients. METHODS: Data from 1761 LA treatments of HoFH patients (n = 10) and compound heterozygous patients (n = 5) collected between 2008 and 2016 were analyzed...
January 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29405622/can-lipoprotein-apheresis-offer-a-therapeutic-role-in-the-management-of-patients-with-refractory-angina-and-raised-lipoprotein-a
#14
EDITORIAL
Tina Z Khan
No abstract text is available yet for this article.
February 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29405619/upcoming-meetings-therapeutic-apheresis-and-dialysis-february-2018
#15
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29404583/differences-in-the-reponses-to-apheresis-therapy-of-patients-with-3-histopathologically-classified-immunopathological-patterns-of-multiple-sclerosis
#16
Lidia Stork, David Ellenberger, Tim Beißbarth, Tim Friede, Claudia F Lucchinetti, Wolfgang Brück, Imke Metz
Importance: Plasma exchange and immunoadsorption are second-line apheresis therapies for patients experiencing multiple sclerosis relapses. Early active multiple sclerosis lesions can be classified into different histopathological patterns of demyelination. Pattern 1 and 2 lesions show T-cell- and macrophage-associated demyelination, and pattern 2 is selectively associated with immunoglobulin and complement deposits, suggesting a humoral immune response. Pattern 3 lesions show signs of oligodendrocyte degeneration...
February 5, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29398508/lipoprotein-apheresis-affects-lipoprotein-particle-subclasses-more-efficiently-compared-to-the-pcsk9-inhibitor-evolocumab-a-pilot-study
#17
Knut Tore Lappegård, Christian Abendstein Kjellmo, Stefan Ljunggren, Karin Cederbrant, Maritha Marcusson-Ståhl, Monica Mathisen, Helen Karlsson, Anders Hovland
Lipoprotein apheresis and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are last therapeutic resorts in patients with familial hypercholesterolemia (FH). We explored changes in lipoprotein subclasses and high-density lipoprotein (HDL) function when changing treatment from lipoprotein apheresis to PCSK9 inhibition. We measured the levels of low-density lipoprotein (LDL) and HDL particle subclasses, serum amyloid A1 (SAA1), paraoxonase-1 (PON1) activity and cholesterol efflux capacity (CEC) in three heterozygous FH patients...
January 4, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29389816/lomitapide-in-homozygous-familial-hypercholesterolemia-cardiology-perspective-from-a-single-center-experience
#18
Simona Sperlongano, Felice Gragnano, Francesco Natale, Laura D'Erasmo, Claudia Concilio, Arturo Cesaro, Enrica Golia, Mario Crisci, Rossella Sperlongano, Fabio Fimiani, Mariagiovanna Russo, Marcello Arca, Giuseppe Limongelli, Paolo Calabrò
AIMS: Homozygous familial hypercholesterolemia (HoFH) is a genetic dyslipidemia characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and accelerated atherosclerosis. Frequently, traditional lipid-lowering therapy is ineffective in these patients, and lipoprotein apheresis is required. Lomitapide has been recently approved for HoFH. We reported our experience in HoFH patients treated with lomitapide, evaluating its efficacy and safety profile. METHODS: Probands suspected for familial hypercholesterolemia were extrapolated from the registry of patients admitted to our cardiology department...
March 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29388056/treatment-preferences-in-germany-differ-among-apheresis-patients-with-severe-hypercholesterolemia
#19
Axel C Mühlbacher, Andrew Sadler, Franz-Werner Dippel, Christin Juhnke
BACKGROUND: Severe hypercholesterolemia is a major risk factor of death in patients with coronary heart disease. New adjunctive drug therapies (proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitors) have gained approval in Europe and the USA. OBJECTIVE: In this empirical study, we documented preferences regarding adjuvant drug therapy in apheresis-treated patients with severe familial hypercholesterolemia. METHODS: We conducted a systematic literature search to identify patient-relevant outcomes in patients with severe hypercholesterolemia currently undergoing apheresis...
January 31, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29380726/genetic-background-and-therapeutic-response-in-generalized-pustular-psoriasis-patients-treated-with-granulocyte-and-monocyte-adsorption-apheresis
#20
Hidenori Ohnishi, Tomonori Kadowaki, Yoko Mizutani, Emi Nishida, Rie Tobita, Namiko Abe, Yukie Yamaguchi, Hikaru Eto, Masaru Honma, Takuro Kanekura, Yukari Okubo, Mariko Seishima, Toshiyuki Fukao, Shigaku Ikeda
No abstract text is available yet for this article.
January 30, 2018: European Journal of Dermatology: EJD
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