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Tae Wan Seung, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Sang Hyun Park, Bong Seok Kwon, Chang Jun Lee, Jeong Eun Kang, Dae Ok Kim, Uk Lee, Ho Jin Heo
The ameliorating effects of the ethyl acetate fraction from Hibiscus sabdariffa L. (EFHS)2 against diabetes mellitus (DM)3 and DM-induced cognitive impairment were investigated on streptozotocin (STZ)4 -induced DM mice. The EFHS groups showed improved hyperglycemia and glucose tolerance compared to the STZ group. Furthermore, their liver and kidney function and lipid metabolic imbalance in the blood serum were effectively recovered. The EFHS groups significantly ameliorated STZ-induced cognitive impairment in Y-maze, passive avoidance, and Morris water maze (MWM)5 tests...
March 2018: Food Research International
Dmitry V Kazakov, Liubov Kyrpychova, Petr Martinek, Petr Grossmann, Petr Steiner, Tomas Vanecek, Michal Pavlovsky, Vladimir Bencik, Michael Michal, Michal Michal
Previous studies showed that ALK is often positive in epithelioid fibrous histiocytoma (EFH). Two cases of EFH with ALK gene fusions have been recorded. Our objective was to study a series of EFH to present histopathological variations of EFH, identify novel ALK gene fusions, and determine whether there is a correlation between histopathological features and particular gene. We investigated 14 cases of EFH, all ALK immunopositive. The cases were assessed histopathologically as well as for ALK and TFE-3 rearrangements using FISH and ALK gene fusions using next-generation sequencing...
January 11, 2018: American Journal of Dermatopathology
Avery B Paxton, Emily A Pickering, Alyssa M Adler, J Christopher Taylor, Charles H Peterson
Structural complexity, a form of habitat heterogeneity, influences the structure and function of ecological communities, generally supporting increased species density, richness, and diversity. Recent research, however, suggests the most complex habitats may not harbor the highest density of individuals and number of species, especially in areas with elevated human influence. Understanding nuances in relationships between habitat heterogeneity and ecological communities is warranted to guide habitat-focused conservation and management efforts...
2017: PloS One
Seema Patel, Aruna Rani, Arun Goyal
Plant pollens are airborne allergens, as their inhalation causes immune activation, leading to rhinitis, conjunctivitis, sinusitis and oral allergy syndrome. A myriad of pollen proteins belonging to profilin, expansin, polygalacturonase, glucan endoglucosidase, pectin esterase, and lipid transfer protein class have been identified. In the present in silico study, the protein domains of fifteen pollen sequences were extracted from the UniProt database and submitted to the interactive web tool SMART (Simple Modular Architecture Research Tool), for finding the protein domain profiles...
October 2017: Computational Biology and Chemistry
Ying Zhang, Shuling Wang, Lingsong Li
EF hand (EFh) domain-containing proteins have been implicated in malignant progression, but their precise functional contributions are uncertain. Here, we report evidence that the EFh protein IBA2 promotes the proliferation of breast cancer cells by facilitating their transit through the G1-S cell-cycle transition. Mechanistic investigations revealed that IBA2 acted at the transcriptional level to promote the expression of the critical cell-cycle regulator cyclin D1. Clinically, we found that levels of IBA2 were significantly upregulated in breast cancer specimens, where its expression correlated positively with histologic grade...
August 1, 2016: Cancer Research
Jie Liu, Xi Ren, Xiaowei Guo, Huanbo Sun, Yong Tang, Zhenghui Luo, Qiong Zhang, Dongxia Zhang, Yuesheng Huang, Jiaping Zhang
OBJECTIVE: To explore the effects of direct current electric fields on directional migration and arrangement of dermal fibroblasts in neonatal BALB/c mice and the related mechanisms. METHODS: Twelve neonatal BALB/c mice were divided into 4 batches. The skin on the back of 3 neonatal mice in each batch was obtained to culture fibroblasts. Fibroblasts of the second passage were inoculated in 27 square cover slips with the concentration of 5 × 10(4) cells per mL. (1) Experiment 1...
April 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Hyeon-Seok Seo, Jin-Hyo Boo, Youn-Jea Kim
The characteristics of thermomagnetic convective flow in a rectangular enclosure heated from below and filled with oil-based nanofluid (EFH-1, Ferrotec.), so called ferrofluid, were numerically investigated. The enclosure contained obstacles with rectangular or triangular configurations mounted on the top and bottom walls. To generate homogeneous magnetic fields, a permanent magnet with a uniform magnetic field strength of 600 kA/m was located in the lower part of the rectangular enclosure, and specified the horizontal or vertical direction...
November 2015: Journal of Nanoscience and Nanotechnology
Hyeon-Seok Seo, Jin-Hyo Boo, Youn-Jea Kim
This study numerically investigated the flow characteristics in a rectangular enclosure filled with oil-based ferrofluid (EFH-1, Ferrotec.) under the influence of external magnetic fields. The rectangular enclosure contained obstacles with different shapes, such as a rectangle and a triangle mounted on the top and bottom wall surfaces. In order to generate external magnetic fields, a permanent magnet was located in the lower part of the rectangular enclosure, and its direction was selected to be either horizontal or vertical...
October 2015: Journal of Nanoscience and Nanotechnology
Joseph G Makin, Benjamin K Dichter, Philip N Sabes
Tracking moving objects, including one's own body, is a fundamental ability of higher organisms, playing a central role in many perceptual and motor tasks. While it is unknown how the brain learns to follow and predict the dynamics of objects, it is known that this process of state estimation can be learned purely from the statistics of noisy observations. When the dynamics are simply linear with additive Gaussian noise, the optimal solution is the well known Kalman filter (KF), the parameters of which can be learned via latent-variable density estimation (the EM algorithm)...
November 2015: PLoS Computational Biology
Shariselle M W Pool, Berend van der Lei
BACKGROUND: This study was undertaken to evaluate dermatochalasis, eyebrow position, and (a)symmetry in both sides in patients before and after bipolar coagulation-assisted orbital (BICO) septo-blepharoplasty, so as to carry out further investigation if these aforementioned aspects improve, persist, or even worsen after this procedure. METHODS: The preoperative and postoperative photographs of 365 patients were evaluated for the (asymmetry in) degree of skin surplus, eyebrow height, and eyelid fissure height (EFH)...
April 2015: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
John M Guinotte, Andrew J Davies
Regional scale habitat suitability models provide finer scale resolution and more focused predictions of where organisms may occur. Previous modelling approaches have focused primarily on local and/or global scales, while regional scale models have been relatively few. In this study, regional scale predictive habitat models are presented for deep-sea corals for the U.S. West Coast (California, Oregon and Washington). Model results are intended to aid in future research or mapping efforts and to assess potential coral habitat suitability both within and outside existing bottom trawl closures (i...
2014: PloS One
Bárbara Serra-Pereira, Karim Erzini, Catarina Maia, Ivone Figueiredo
Understanding of spatio-temporal patterns of sensitive fish species such as skates (Rajidae) is essential for implementation of conservation measures. With insufficient survey data available for these species in Portuguese Continental waters, this study shows that fishery-dependent data associated with fishers' knowledge can be used to identify potential Essential Fish Habitats (EFH) for seven skate species. Sites with similar geomorphology were associated with the occurrence of juveniles and/or adults of the same group of species...
May 2014: Environmental Management
Ning Ding, Norman F Neumann, Luke M Price, Shannon L Braithwaite, Aru Balachandran, Miodrag Belosevic, Mohamed Gamal El-Din
Disposal of tissues and organs associated with prion accumulation and infectivity in infected animals (designated as Specified Risk Materials [SRM]) is strictly regulated by the Canadian Food Inspection Agency (CFIA); however, the contamination of wastewater from slaughterhouses that handle SRM still poses public concern. In this study, we examined for the first time the partitioning of infectious prions in rendering plant wastewater and found that a large proportion of infectious prions were partitioned into the scum layer formed at the top after gravity separation, while quite a few infectious prions still remained in the wastewater...
February 1, 2014: Science of the Total Environment
Ephraim Woods, Kevin D Heylman, Amanda K Gibson, Adam P Ashwell, Sean R Rossi
The reactions of NO(y) species in the atmosphere with sea spray aerosol replace halogen anions with nitrate. These experiments show the effect of increasing the nitrate content of model sea spray aerosol particles on the morphology changes and the phase transitions driven by changes in relative humidity (RH). The components of the model particles include H2O, Na+, Mg2+, Cl-, NO3-, and SO4(2-). Tandem differential mobility analyzer (TDMA) measurements yield the water content and efflorescence relative humidity (ERH) of these particles, and probe molecule spectroscopic measurements reveal subsequent phase transitions and partially characterize the salt composition on the surface of dry particles...
May 23, 2013: Journal of Physical Chemistry. A
Caroline M Van daele, Tim De Meyer, Marc L De Buyzere, Thierry C Gillebert, Simon L I J Denil, Sofie Bekaert, Julio A Chirinos, Patrick Segers, Guy G De Backer, Dirk De Bacquer, Ernst R Rietzschel
OBJECTIVES: Whereas the importance of family history (FH) is widely recognized in cardiovascular risk assessment, its full potential could be underutilized, when applied with its current simple guidelines-based definition (cFH): presence of premature cardiovascular disease (CVD) in a first-degree relative. We tested the added value of a new, extended family history definition (eFH), also taking into account later onset of disease, second-degree relatives and number of affected relatives, on profiling cardiovascular risk and atherosclerotic burden in the general population...
2013: PloS One
Ning Ding, Norman F Neumann, Luke M Price, Shannon L Braithwaite, Aru Balachandran, Gordon Mitchell, Miodrag Belosevic, Mohamed Gamal El-Din
The kinetics of ozone inactivation of infectious prion protein (PrP(Sc), scrapie 263K) was investigated in ozone-demand-free phosphate-buffered saline (PBS). Diluted infectious brain homogenates (IBH) (0.01%) were exposed to a predetermined ozone dose (10.8 ± 2.0 mg/liter) at three pHs (pH 4.4, 6.0, and 8.0) and two temperatures (4°C and 20°C). The inactivation of PrP(Sc) was quantified by determining the in vitro destruction of PrP(Sc) templating properties using the protein misfolding cyclic amplification (PMCA) assay and bioassay, which were shown to correlate well...
April 2013: Applied and Environmental Microbiology
Chaney Widmer, Jonathan P Deshazo, Joann Bodurtha, John Quillin, Heather Creswick
Given the widespread adoption of electronic medical records and recent emergence of electronic family history tools, we examined genetic counselors' perspectives on the emerging technology of the personal health record (PHR)-based family history tool that links to an electronic medical record (EMR). Two-hundred thirty-three genetic counselors responded to an on-line survey eliciting current use of electronic family history (EFH) tools and familiarity with PHR-based family history tools. Additionally, after being shown a series of screen shots of a newly developed PHR-based family history tool based on the U...
June 2013: Journal of Genetic Counseling
Lauren Tuttle, Qingyu Meng, Jacqueline Moya, Douglas O Johns
OBJECTIVE: To explore age-related behavior differences between older and younger adults, and to review how older adult activity patterns are considered in evaluating the potential risk of exposure to environmental pollutants. METHODS: Activity pattern data and their use in risk assessments were analyzed using the U.S. EPA Exposure Factors Handbook (EFH), U.S. EPA Consolidated Human Activity Pattern Database (CHAD), and peer-reviewed literature describing human health risk assessments...
March 2013: Journal of Aging and Health
Eric Soupene, Frans A Kuypers
BACKGROUND: Unsaturated fatty acids are susceptible to oxidation and damaged chains are removed from glycerophospholipids by phospholipase A(2). De-acylated lipids are then re-acylated by lysophospholipid acyltransferase enzymes such as LPCAT1 which catalyses the formation of phosphatidylcholine (PC) from lysoPC and long-chain acyl-CoA. RESULTS: Activity of LPCAT1 is inhibited by Ca(2+), and a Ca(2+)-binding motif of the EF-hand type, EFh-1, was identified in the carboxyl-terminal domain of the protein...
2012: BMC Biochemistry
B Toth, D Nagel
N-ethyl-N-formylhydrazine (EFH) was administered as a 0.02% solution in drinking water continuously for life to randomly bred Swiss mice, from 6 weeks of age. The treatment induced tumors of the lungs, blood vessels, liver, gall bladder and preputial glands. The tumor incidences in treated females for these five tissues were 98, 94, 0, 2 and 0%, whereas in the treated males they were 78, 64, 26, 8 and 10%, respectively. Histopathologically the lesions were adenomas and adenocarcinomas of the lungs, angiomas and angiosarcomas of blood vessels, benign hepatomas, liver cell carcinomas, adenomas and adenocarcinomas of the gall bladder, and squamous cell papillomas and carcinomas of preputial glands...
January 1980: Carcinogenesis
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