Susana Rubio-Guevara, Karyn Olascuaga-Castillo, Elena Cáceres-Andonaire, Dan Altamirano-Sarmiento, Olga Caballero-Aquiño, Elena Mantilla-Rodríguez, Julio Hilario-Vargas, Maxim Berezovski, José Andrés Morgado-Díaz
Tumor radioresistance, or the lack of control of certain tumors with this treatment, can result in locoregional recurrence; therefore, there is great interest in understanding the underlying biology and developing strategies to overcome this problem. MicroRNAs (miRNAs, miRs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level and participate in cancer invasion, progression, metastasis, and therapeutic resistance. Emerging evidence indicates that miRNAs play a critical role in modulating key cellular pathways that mediate response to radiation, influencing radiosensitivity of cancer cells through interaction with other biological processes such as cell cycle checkpoints, apoptosis, autophagy, epithelialmesenchymal transition, and cancer stem cells...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology