Nasrin Ranjbar, Mohammadreza Raeisi, Mohammad Barzegar, Amir Ghorbanihaghjo, Siamak Shiva, Shahram Sadeghvand, Sohrab Negargar, Haniyeh Poursistany, Sina Raeisi
Recurrent seizures in epilepsy may lead to progressive neuronal damage, which can diminish health-related quality of life. Evaluation and control of pathological processes in the brain is valuable. It seems imperative that new markers and approaches for seizure alleviation be discovered. Klotho (Kl), an antiaging protein, has protective effects in the brain against neurological disorders. It may also have antiseizure effects by improving creatine transfer to the brain, upregulating excitatory amino acid transporters, and inhibiting insulin/insulin-like growth factor-1 (IGF-1), Wingless (Wnt), transforming growth factor-beta (TGF-β), and retinoic-acid-inducible gene-I (RIG-I)/nuclear translocation of nuclear factor-κB (NF-κB) pathways...
August 25, 2023: Brain Research