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daunorubicin 60 mrc aml15

Alan K Burnett, Robert K Hills, Donald Milligan, Lars Kjeldsen, Jonathan Kell, Nigel H Russell, John A L Yin, Ann Hunter, Anthony H Goldstone, Keith Wheatley
PURPOSE: Antibody-directed chemotherapy for acute myeloid leukemia (AML) may permit more treatment to be administered without escalating toxicity. Gemtuzumab ozogamicin (GO) is an immunoconjugate between CD33 and calicheamicin that is internalized when binding to the epitope. We previously established that it is feasible to combine GO with conventional chemotherapy. We now report a large randomized trial testing the addition of GO to induction and/or consolidation chemotherapy in untreated younger patients...
February 1, 2011: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
William J Kell, Alan K Burnett, Raj Chopra, John A L Yin, Richard E Clark, Ama Rohatiner, Dominic Culligan, Ann Hunter, Archie G Prentice, Donald W Milligan
The feasibility of combining gemtuzumab ozogamicin (GO) with intensive chemotherapy as first-line treatment of acute myeloid leukemia (AML) was assessed in 72 patients, aged 17 to 59 years, as a prelude to the United Kingdom Medical Research Council (MRC) AML15 trial. Sixty-four patients received induction chemotherapy (DAT [daunorubicin, ara-C, thioguanine], DA [daunorubicin, ara-C], or FLAG-Ida [fludarabine, ara-C, G-CSF, idarubicin]) with GO on day 1. It was possible to give GO 3 mg/m2 with course 1, but 6 mg/m2 with course 1 or GO in a dose of 3 mg/m2 with consecutive courses was not feasible because of hepatotoxicity and delayed hematopoietic recovery...
December 15, 2003: Blood
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