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https://www.readbyqxmd.com/read/29318853/-effects-of-electroacupuncture-on-adaptive-hypertrophy-of-gastrocnemius-and-proliferation-and-differentiation-of-muscle-satellite-cells-in-rats
#1
Dan-Dan Zhao, Cheng-Lin Tang, Si-Qin Huang, Ao Luo, An-Ning Zhang, Quan-Hu Guo, Jing Cao, Rui-Qi Gao
OBJECTIVE: To explore the effects and mechanism of different duration electroacupuncture (EA) on adaptive hypertrophy of gastrocnemius and the expressions of proliferation cell nuclear antigen (PCNA), paired box transcription factor 7 (Pax 7), myogenic differentiation antigen (MyoD 1), myogenin (MyoG), myosin heavy chain-Ⅰ(Myh 7), transforming growth factor-β 1 (TGF-β 1), Smad 3 in rats. METHODS: Twenty-four SD adult male rats were randomly divided into normal, two-week EA (A 2), four-week EA (A 4) and eight-week EA (A 8) groups, 6 rats in each group...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29241740/aberrant-pax-8-expression-in-well-differentiated-papillary-mesothelioma-and-malignant-mesothelioma-of-the-peritoneum-a-clinicopathologic-study
#2
Deyin Xing, Natalie Banet, Rajni Sharma, Russell Vang, Brigitte M Ronnett, Peter B Illei
Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, with common features including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is commonly used for differentiating peritoneal MM from serous carcinoma, but the diagnostic value of Pax-8 for distinguishing WDPM from borderline or low-grade serous tumors is unknown...
December 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29216879/anti-diabetic-potential-of-sapium-ellipticum-hochst-pax-leaf-extract-in-streptozotocin-stz-induced-diabetic-wistar-rats
#3
Osasenaga Macdonald Ighodaro, Oluseyi Adeboye Akinloye
BACKGOUND: Ethnobatanical survey associates Sapium ellipticum (SE) with antidiabetic usage among other medicinal functions in different parts of Africa. More importantly, previous studies on the plant extract in our laboratory showed that SE has significant effects on the activities of carbohydrate metabolizing enzymes such as glucokinase, glucose-6-phosphatase, α-amylase and α-glucosidase. In view of these, the anti-diabetic potential of the plant leaf extract in streptozotocin (STZ)-induced diabetes rat model (Wistar strain) was examined...
December 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29197096/observations-on-the-origin-of-ovarian-cortical-inclusion-cysts-in-women-undergoing-risk-reducing-salpingo-oophorectomy
#4
Kay J Park, Prusha Patel, Irina Linkov, Anjali Jotwani, Noah Kauff, Malcolm C Pike
AIMS: Evidence suggests that up to 70% of high-grade serous ovarian carcinomas (HGSCs) potentially arise from fallopian tube fimbriae, and that many of the remaining cases arise from within the ovary in cortical inclusion cysts (CICs) with a Müllerian phenotype (Müllerian-CICs). It has been proposed that Müllerian-CICs arise either from metaplasia of mesothelial ovarian surface epithelium (OSE) entrapped within the ovary after ovulation, or from normal tubal cells entrapped post-ovulation...
December 2, 2017: Histopathology
https://www.readbyqxmd.com/read/29194708/metastatic-serous-carcinoma-presenting-as-inflammatory-carcinoma-over-the-breast-report-of-two-cases-and-literature-review
#5
Gauri Panse, Veerle Bossuyt, Christine J Ko
Non-mammary metastases involving breast are rare and most commonly involve the breast parenchyma. Infrequently, metastasis from an extramammary primary site presents as inflammatory carcinoma over the breast. Diagnosis of such lesions can be challenging, especially in patients with coexisting primary breast carcinoma. Few such cases have been described in literature; however, none of the previously reported cases had a prior history of primary breast carcinoma. We present 2 patients with history of breast carcinoma and serous carcinoma of ovarian/peritoneal origin that presented with inflammatory carcinoma over the breast...
December 1, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29131558/cytologic-findings-of-an-adult-rhabdomyoma-in-the-parapharyngeal-space-a-report-of-a-case-and-review-of-the-literature
#6
Josephine Kamtai Dermawan, Erika Doxtader, Deborah J Chute, Maria Luisa Policarpio-Nicolas
Adult extracardiac rhabdomyomas are rare benign mesenchymal tumor arising from skeletal muscle. While they are often located in the larynx and pharynx, the incidence in the parapharyngeal area is extremely rare with only 1 documented cytology case report to date. We report a case of an adult extracardiac rhabdomyoma in the parapharyngeal space diagnosed cytologically with subsequent histologic confirmation. The patient is a 57-year-old man with history of weight loss, hematuria, dysphagia, and airway encroachment...
November 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28960456/primary-large-cell-neuroendocrine-carcinoma-of-the-skin-an-under-recognized-entity-and-a-mimic-of-metastatic-disease
#7
Ian Marie Lano, Daniel Rayson, Thomas Arnason, Noreen M G Walsh
Primary large cell neuroendocrine carcinomas of the skin are exceptionally rare and can be diagnosed only when a metastasis from another organ has been excluded. We report the case of a 62-year-old woman with a cutaneous papule on the mid-chest which generated a differential diagnosis of vascular lesion and basal cell carcinoma. Following excision, microscopic evaluation revealed a dermal large cell undifferentiated carcinoma, with a brisk mitotic rate and focal geographic necrosis. Mucin production was absent...
January 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28946910/primary-paranasal-sinus-hyalinizing-clear-cell-carcinoma-a-case-report
#8
Batool M AlAli, Mohammed J Alyousef, Ahmad Salah Kamel, Mohammad A Al Hamad, Mohammad H Al-Bar, Roaa M Algowiez
BACKGROUND: Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumour of salivary glands that was first described as a distinct entity in 1994 by Milchgrub et al. EWSR1-ATF1 fusion was found to be specific for this tumour. The majority of the reported cases of HCCC arise from minor salivary glands within the oral cavity. Primary HCCC of the paranasal sinus is extremely uncommon. To our knowledge, only three cases have been reported in the English literature. Herein, we present a case of HCCC of the posterior ethmoid/maxillary sinus...
September 25, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28945333/targeting-the-hemopexin-like-domain-of-latent-matrix-metalloproteinase-9-prommp-9-with-a-small-molecule-inhibitor-prevents-the-formation-of-focal-adhesion-junctions
#9
Vincent M Alford, Anushree Kamath, Xiaodong Ren, Kunal Kumar, Qianwen Gan, Monaf Awwa, Michael Tong, Markus A Seeliger, Jian Cao, Iwao Ojima, Nicole S Sampson
A lack of target specificity has greatly hindered the success of inhibitor development against matrix metalloproteinases (MMPs) for the treatment of various cancers. The MMP catalytic domains are highly conserved, whereas the hemopexin-like domains of MMPs are unique to each family member. The hemopexin-like domain of MMP-9 enhances cancer cell migration through self-interaction and heterointeractions with cell surface proteins including CD44 and α4β1 integrin. These interactions activate EGFR-MAP kinase dependent signaling that leads to cell migration...
November 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28877071/uncommon-localization-of-extrarenal-xp11-2-translocation-associated-renal-cell-carcinoma-rcc-case-report
#10
Jaudah Ahmed Al-Maghrabi, Mohamad Nidal Khabaz
The World Health Organization has recognized Xp11.2 translocation-associated renal cell carcinoma (RCC) as a distinct neoplasm that arises within the kidney. Although many reports of extrarenal carcinoma may be found in the literature, to the best of our knowledge, Xp11 translocation-associated RCC with intact kidneys has not been documented. This report describes a multilobulated right retroperitoneal soft tissue mass (7.9×5.3×12.6 cm) of a 37-year-old man complaining of abdominal pain in the right side...
September 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28877070/effects-of-hydrochloric-acid-and-formic-acid-decalcification-on-breast-tumor-biomarkers-and-her2-fluorescence-in-situ-hybridization
#11
Beth Z Clark, Jennifer M Yoest, Agnieszka Onisko, David J Dabbs
Biomarker analysis of metastatic breast carcinoma (MBC) is routinely recommended by ASCO/CAP guidelines, and establishing a diagnosis of MBC often requires immunohistochemistry (IHC). The reliability of breast tumor biomarkers and breast-specific markers on decalcified tissues has not been extensively studied. We performed IHC studies on breast tumors exposed to hydrochloric acid (HCl) and formic acid (FA) decalcification solutions, and HER2 fluorescence in situ hybridization on a subset of these tumors to establish a protocol for handling bone specimens with suspicion for MBC...
September 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28841887/a-case-of-intravascular-large-b-cell-lymphoma-presenting-as-nodular-goiter
#12
Bo Luo, Jia-Mei Chen, Jie Liu, Wen-He Li, Yu-Xiang Shi, Pan Zeng, Yong-Hui Xie, Hong-Feng Zhang
BACKGROUND: Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is rare and highly aggressive and that may progressively involve many organs. CNS (central nervous system), BM (bone marrow) and skin are the most common systems involved. To date, only 2 cases of IVLBCL involving the thyroid have been reported. CASE PRESENTATION: Here, we report a case of IVLBCL involving the thyroid and accompanied by bilateral nodular goiter...
August 25, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28777151/does-strong-and-diffuse-pax-8-positivity-occur-in-primary-lung-carcinoma-an-immunohistochemical-study-of-418-cases-and-review-of-the-literature
#13
Kelsey E McHugh, Andrea V Arrossi, Carol F Farver, Sanjay Mukhopadhyay
Although rare cases of PAX-8-positive primary lung carcinoma have been reported, details of staining distribution and intensity in such cases are limited. The aim of this study was to determine whether strong and diffuse PAX-8 staining can occur in primary lung carcinoma. Immunohistochemical staining for PAX-8 (Rabbit polyclonal, 10336-1-AP; Proteintech) was performed on whole-tissue sections from 418 resected primary lung carcinomas. PAX-8 was positive in 5/418 (1.2%) cases, all of which were large cell neuroendocrine carcinomas...
August 2, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28767609/sinonasal-renal-cell-like-adenocarcinoma-a-unique-variant-of-primary-clear-cell-carcinoma-of-the-head-and-neck-the-first-reported-case-in-korea
#14
Nah-Ihm Kim, Jung-In Yang, Sung-Sun Kim, Ji-Shin Lee, Sang-Chul Lim, Shin Jung, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee
RATIONALE: Primary sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare and unique neoplasm. PATIENT CONCERNS: A 63-year-old man presented with repeated epistaxis, nasal obstruction and hyposmia of 2-month duration. Radiological studies revealed a mass of the left ethmoid sinus involving anterior skull base. DIAGNOSIS: The patient was treated with craniofacial resection, bifrontal craniotomy combined with an endonasal endoscopic approach...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28690098/m%C3%A3-llerian-adenosarcoma-of-the-urinary-bladder-clinicopathologic-and-immunohistochemical-features-with-novel-genetic-aberrations
#15
Joseph Sanfrancesco, Sean R Williamson, Jennifer B Kum, Shaobo Zhang, Mingsheng Wang, Antonio Lopez-Beltran, Rodolfo Montironi, Thomas A Gardner, Liang Cheng
BACKGROUND: Müllerian adenosarcoma is a biphasic neoplasm most commonly occurring in the uterus and less frequently of the ovary. It has been rarely described to occur in other sites such as peritoneum and liver. PATIENTS AND METHODS: In this study, we report the clinicopathologic, immunohistochemical and molecular features of a primary Müllerian adenosarcoma of the urinary bladder in a 62-year-old woman. To our knowledge, this is the first report of detailed pathologic characterization of Müllerian adenosarcoma primary to the urinary bladder in the literature...
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28682831/liver-metastases-from-renal-oncocytoma-with-vascular-extension
#16
Giovanni Cacciamani, Luca Cima, Miriam Ficial, Giovanni Novella, Salvatore Siracusano, Umberto Tedeschi, Matteo Balzarro, Umberto Montin, Maria A Cerruto, Vincenzo De Marco, Antonio B Porcaro, Ondrej Hes, Antonia DʼErrico, Guido Martignoni, Claudio Ghimenton, Gianluigi Zaza, Walter Artibani, Matteo Brunelli, Albino Eccher
The 2016 World Health Organization Renal Tumor Classification defines renal oncocytoma (RO) as a benign epithelial tumor; however, malignant histopathologic features have been documented. Rare cases with metastases have been reported. We describe the case of a 62-year-old woman who was referred to the Urology Clinic for a routine work-up. Magnetic resonance imaging and computerized tomography showed a 7-cm mass in the middle and lower portions of the left kidney and 2 suspected liver metastases. The patient underwent surgery...
July 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28680949/sapium-ellipticum-hochst-pax-ethanol-leaf-extract-maintains-lipid-homeostasis-in-streptozotocin-induced-diabetic-rats
#17
Osasenaga Mcdonald Ighodaro, Oluseyi Adeboye Akinloye, Regina Ngozi Ugbaja, Samuel Olatunbosun Omotainse
Dyslipidemia is a common metabolic disorder especially in diabetes mellitus (DM). In this study, the ability of Sapium ellipticum (SE) leaf extract to restore lipid homeostasis in streptozotocin-induced diabetes was examined. DM was induced in experimental rats (Wistar strains) using single intraperitoneal dose (55 mg/kg body weight {BW}) of streptozotocin (STZ). Treatment of diabetic rats with SE was oral (p.o), at doses of 400 and 800 mg kg(-1) BW, twice daily at 8 h interval for 21 days. Lipid parameters were analyzed in the serum of rats using test kits...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28612664/primary-central-nervous-system-t-cell-lymphoma-with-aberrant-expression-of-cd20-and-cd79a-a-diagnostic-pitfall
#18
Neha Gupta, Mansoor Nasim, Silvia G Spitzer, Xinmin Zhang
Primary central nervous system T-cell lymphoma (PCNSTCL) is rare, accounting for 2% of CNS lymphomas. We report the first case of PCNSTCL with aberrant expression of CD20 and CD79a in an 81-year-old man with a left periventricular brain mass. A biopsy revealed dense lymphoid infiltrate consisting of medium-sized cells in a background of gliosis and many histiocytes. The lymphoid cells were positive for CD2, CD3, CD7, CD8, T-cell intracellular antigen-1, granzyme B, CD20, and CD79a and negative for CD4, CD5, PAX-5, OCT-2, BOB-1, human herpes virus-8, and Epstein-Barr virus-encoded small RNAs...
October 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28603637/t-type-voltage-gated-ca-2-channels-do-not-contribute-to-the-negative-feedback-regulation-of-myogenic-tone-in-murine-superior-epigastric-arteries
#19
Brendan Mullan, Jessica Pettis, William F Jackson
T-type voltage-gated Ca(2+) channels (CaV3.2 VGCC) have been hypothesized to control spontaneous transient outward currents (STOCs) through large-conductance Ca(2+)-activated K(+) channels (BKCa), and contribute to the negative-feedback regulation of myogenic tone. We tested this hypothesis in superior epigastric arteries (SEAs) isolated from male C57BL/6 mice. SEAs were isolated and enzymatically dissociated to obtain single smooth muscle cells (SMCs) for whole-cell recording of paxilline-sensitive (PAX, 1 μmol/L) STOCs at -30 mV, or cannulated and studied by pressure myography (80 cm H2O, 37°C)...
June 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28554748/nephrogenic-adenoma-of-the-urinary-tract-a-6-year-single-center-experience
#20
Didem Turcan, Mustafa Fuat Acikalin, Evrim Yilmaz, Funda Canaz, Deniz Arik
BACKGROUND: Nephrogenic adenoma is an uncommon benign lesion that occurs at several sites in urinary tract, from the renal pelvis to urethra, with the highest frequency in urinary bladder. Nephrogenic adenoma displays a broad spectrum of architectural and cytological features. Hence, recognition of its characteristic histopathological features is needed to distinguish this lesion from its mimickers. MATERIALS AND METHODS: A retrospective series of 21 cases of nephrogenic adenoma in 18 patients, which were diagnosed in our department between 2010 and 2016, were analyzed...
March 25, 2017: Pathology, Research and Practice
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