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https://www.readbyqxmd.com/read/27872575/the-significance-and-occurrence-of-tnf-receptor-polymorphisms-in-the-saudi-population
#1
Faris Q Alenzi
Background and objective: On the basis that the inflammatory effects of TNF (tumour necrosis factor) are predominantly mediated through interaction with the TNF receptor-1 (TNFRSF1A), the current study was designed to establish the prevalence of the mutations, R92Q and P46L TNFRSF1A polymorphisms both in the general healthy Saudi population, and in Saudi patients carrying inflammatory diseases such as atherosclerosis or rheumatoid arthritis. We felt it important to report the frequency of the mutations, R92Q and P46L TNFRSF1A polymorphisms in healthy Saudi individuals, and those with inflammatory conditions, as well as to describe the pattern of immunological factors in individuals expressing R92Q or P46L TNFRSF1A...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27870345/betwixt-and-between-intracranial-perspective-on-zygomatic-arch-plasticity-and-function-in-mammals
#2
Erin M Franks, Nathan E Holton, Jeremiah E Scott, Kevin R McAbee, Jason T Rink, Kazune C Pax, Adam C Pasquinelly, Joseph P Scollan, Meghan M Eastman, Matthew J Ravosa
The zygomatic arch is morphologically complex, providing a key interface between the viscerocranium and neurocranium. It also serves as an attachment site for masticatory muscles, thereby linking it to the feeding apparatus. Though morphological variation related to differential loading is well known for many craniomandibular elements, the adaptive osteogenic response of the zygomatic arch remains to be investigated. Here, experimental data are presented that address the naturalistic influence of masticatory loading on the postweaning development of the zygoma and other cranial elements...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27810169/conservatism-and-variability-of-gene-expression-profiles-among-homeologous-transcription-factors-in-xenopus-laevis
#3
Minoru Watanabe, Yuuri Yasuoka, Shuuji Mawaribuchi, Aya Kuretani, Michihiko Ito, Mariko Kondo, Haruki Ochi, Hajime Ogino, Akimasa Fukui, Masanori Taira, Tsutomu Kinoshita
Xenopus laevis has an allotetraploid genome of 3.1Gb, in contrast to the diploid genome of a closely related species, Xenopus tropicalis. Here, we identified 412 genes (189 homeolog pairs, one homeologous gene cluster pair, and 28 singletons) encoding transcription factors (TFs) in the X. laevis genome by comparing them with their orthologs from X. tropicalis. Those genes include the homeobox gene family (Mix/Bix, Lhx, Nkx, Paired, POU, and Vent), Sox, Fox, Pax, Dmrt, Hes, GATA, T-box, and some clock genes...
October 31, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27765277/ovarian-cancer-presenting-as-an-axillary-mass-case-series-and-literature-review
#4
B Ilhan, B Kılıç, H Karanlik
AIM: Ovarian cancer is a common cause of death in women worldwide. The purpose of this article was to report a case series and draw physicians' attention to the benefits of histpathologic techniques in determining uncommon metastatic diseases. METHODS: In this study, we report a case series of axillary involvement of ovarian cancer in 6 patients. The data were collected between 2006 and 2015 by analyzing patient's characteristics, and biochemical and immunohistochemical features...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27764127/de-novo-sequencing-and-assembly-analysis-of-the-pseudostellaria-heterophylla-transcriptome
#5
Jun Li, Wei Zhen, Dengkai Long, Ling Ding, Anhui Gong, Chenghong Xiao, Weike Jiang, Xiaoqing Liu, Tao Zhou, Luqi Huang
Pseudostellaria heterophylla (Miq.) Pax is a mild tonic herb widely cultivated in the Southern part of China. The tuberous roots of P. heterophylla accumulate high levels of secondary metabolism products of medicinal value such as saponins, flavonoids, and isoquinoline alkaloids. Despite numerous studies on the pharmacological importance and purification of these compounds in P. heterophylla, their biosynthesis is not well understood. In the present study, we used Illumina HiSeq 4000 sequencing platform to sequence the RNA from flowers, leaves, stem, root cortex and xylem tissues of P...
2016: PloS One
https://www.readbyqxmd.com/read/27631338/morphological-immunohistochemical-and-chromosomal-analysis-of-multicystic-chromophobe-renal-cell-carcinoma-an-architecturally-unusual-challenging-variant
#6
Maria Pané Foix, Ana Dunatov, Petr Martinek, Enric Condom Mundó, Saul Suster, Maris Sperga, Jose I Lopez, Monika Ulamec, Stela Bulimbasic, Delia Perez Montiel, Reza Alaghehbandan, Kvetoslava Peckova, Krystina Pivovarcikova, Daum Ondrej, Pavla Rotterova, Faruk Skenderi, Kristyna Prochazkova, Martin Dusek, Milan Hora, Michal Michal, Ondrej Hes
Chromophobe renal cell carcinoma (ChRCC) is typically composed of large leaf-like cells and smaller eosinophilic cells arranged in a solid-alveolar pattern. Eosinophilic, adenomatoid/pigmented, or neuroendocrine variants have also been described. We collected 10 cases of ChRCC with a distinct multicystic pattern out of 733 ChRCCs from our registry, and subsequently analyzed these by morphology, immunohistochemistry, and array comparative genomic hybridization. Of the 10 patients, 6 were males with an age range of 50-89 years (mean 68, median 69)...
December 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27573549/induction-of-ttf-1-or-pax-8-expression-on-proliferation-and-tumorigenicity-in-thyroid-carcinomas
#7
Célia Dupain, Hafiz M Ali, Tarik Ait Mouhoub, Giorgia Urbinati, Liliane Massaad-Massade
TTF-1 and PAX-8 are responsible for thyroid organogenesis and for maintenance of differentiation in thyrocytes. Thus, we hypothesized that the induction of these two transcription factors could affect proliferation and tumorigenicity. Moreover, the ability of various pharmacological agents to modulate expression of the TTF-1 and PAX-8 and their effects on apoptosis were also analysed. For this purpose, cell lines derived from papillary (TPC-1 and BHP 10-3) and anaplastic (ARO) thyroid carcinomas were stably transfected with expression vectors containing TTF-1 or PAX-8 genes...
September 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27550513/anaplastic-transformation-of-papillary-thyroid-carcinoma-only-seen-in-pleural-metastasis-a-case-report-with-review-of-the-literature
#8
Hyunsung Kim, Yong Wook Park, Young-Ha Oh, Jongmin Sim, Jae Y Ro, Ju Yeon Pyo
Anaplastic transformation of papillary thyroid carcinoma (PTC) at distant metastatic sites is extremely rare, and there have been fewer than 20 reported cases in the literature. A 61-year-old woman presented with 1-week history of dyspnea. Her past medical history was remarkable because, 19 years ago, she underwent nearly total thyroidectomy and radical neck dissection due to PTC. Computed tomography of the chest revealed a 1.7 cm nodule in the lung and diffuse pleural thickening. Gun biopsy of the lung nodule revealed metastatic PTC with typical histology...
August 22, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27490539/upregulation-of-human-st8sia-vi-%C3%AE-2-8-sialyltransferase-gene-expression-by-physcion-in-sk-n-be-2-c-human-neuroblastoma-cells
#9
Hyun-Kyoung Yoon, Hyun-Kyu An, Min Jung Ko, Kyoung-Sook Kim, Seo-Won Mun, Dong-Hyun Kim, Cheol Min Kim, Cheorl-Ho Kim, Young Whan Choi, Young-Choon Lee
In this research, we firstly demonstrated that physcion, an anthraquinone derivative, specifically increased the expression of the human α2,8-sialyltransferase (hST8Sia VI) gene in SK-N-BE(2)-C human neuroblastoma cells. To establish the mechanism responsible for the up-regulation of hST8Sia VI gene expression in physcion-treated SK-N-BE(2)-C cells, the putative promoter region of the hST8Sia VI gene was functionally characterized. Promoter analysis with serially truncated fragments of the 5'-flanking region showed that the region between -320 and -240 is crucial for physcion-induced transcription of hST8Sia VI in SK-N-BE(2)-C cells...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27486747/skeletal-muscle-regeneration-and-oxidative-stress-are-altered-in-chronic-kidney-disease
#10
Keith G Avin, Neal X Chen, Jason M Organ, Chad Zarse, Kalisha O'Neill, Richard G Conway, Robert J Konrad, Robert L Bacallao, Matthew R Allen, Sharon M Moe
Skeletal muscle atrophy and impaired muscle function are associated with lower health-related quality of life, and greater disability and mortality risk in those with chronic kidney disease (CKD). However, the pathogenesis of skeletal dysfunction in CKD is unknown. We used a slow progressing, naturally occurring, CKD rat model (Cy/+ rat) with hormonal abnormalities consistent with clinical presentations of CKD to study skeletal muscle signaling. The CKD rats demonstrated augmented skeletal muscle regeneration with higher activation and differentiation signals in muscle cells (i...
2016: PloS One
https://www.readbyqxmd.com/read/27446571/paired-box-gene-2-is-associated-with-estrogen-receptor-%C3%AE-in-ovarian-serous-tumors-potential-theory-basis-for-targeted-therapy
#11
Min Wang, Haifen Ma
It has been suggested that Paired box gene (PAX)2 is activated by estradiol via estrogen receptor (ER)α in breast and endometrial cancer. The expression of PAX2 was restricted to ovarian serous tumors and only one case was positive in borderline mucinous tumor in our previous study. In the present study, immunohistochemistry was performed to assess the expression of ERα in 58 cases of ovarian serous tumors, including 30 serous cystadenomas, 16 borderline serous cystadenomas, 12 serous carcinomas and 67 cases of ovarian mucinous tumors, including 29 mucinous cystadenoma, 23 borderline mucinous cystadenoma and 15 mucinous carcinoma, which were the same specimens with detection of PAX2 expression...
August 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27438608/benign-m%C3%A3-llerian-glandular-inclusions-in-men-undergoing-pelvic-lymph-node-dissection
#12
Alexander J Gallan, Tatjana Antic
Benign müllerian-type glandular inclusions in lymph nodes are commonly seen in women, but to our knowledge, there have only been 4 reported cases in men. Distinction of these glandular structures from metastatic adenocarcinoma is crucial for proper staging, prognosis, and treatment of the patient. We report 3 cases of benign müllerian-type glandular inclusions in men undergoing either prostatectomy or cystoprostatectomy with lymph node dissection for treatment of prostatic adenocarcinoma and/or urothelial carcinoma...
November 2016: Human Pathology
https://www.readbyqxmd.com/read/27432276/gfap-expression-is-regulated-by-pax3-in-brain-glioma-stem-cells
#13
Xing Su, Xiaojiang Liu, Lanchun Ni, Wei Shi, Hui Zhu, Jinlong Shi, Jian Chen, Zhikai Gu, Yilu Gao, Qing Lan, Qingfeng Huang
Glioblastomas are understood to evolve from brain glioma stem cells (BGSCs), and yet the biology underlying this model of tumorigenesis is largely unknown. Paired box 3 protein (Pax3) is a member of the paired box (Pax) family of transcription factors that is normally expressed during embryonic development, but has recently been implicated in tumorigenesis. The present study demonstrated that Pax3 is differentially expressed in U87MG human glioma cell, BGSC and normal 1800 human astrocyte lines. Herein, we identified that the glial fibrillary acidic protein (GFAP), a major intermediate filament protein of mature astrocytes, is directly downregulated during the differentiation of BGSCs via the binding of Pax3 to the promoter region of GFAP...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27416670/-testicular-malignant-leydig-cell-tumor-a-case-report
#14
Wei Lu, Meng Zhang, Shu-peng Wang, Xiang Wang, Zhi-ming Cai
OBJECTIVE: To investigate the clinicopathological features of testicular malignant Leydig cell tumor (TMLCT) and improve the non-invasive diagnosis of the disease. METHODS: We retrospectively analyzed the clinicopathological data on a case of TMLCT, detected the circulating tumor cells (CTC) in the peripheral venous blood, and reviewed the related literature. RESULTS: The patient, a 47-year-old male, underwent radical orchidoepididymectomy under general anesthesia...
May 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/27400918/mammary-analog-secretory-carcinoma-masc-involving-the-thyroid-gland-a-report-of-the-first-3-cases
#15
Jennifer Dettloff, Raja R Seethala, Todd M Stevens, Margaret Brandwein-Gensler, Barbara A Centeno, Kristen Otto, Julia A Bridge, Justin A Bishop, Marino E Leon
Salivary gland-type tumors have been rarely described in the thyroid gland. Mammary Analog Secretory Carcinoma (MASC) is a recently defined type of salivary gland carcinoma characterized by a t(12;15)(p13;q25) resulting in an ETV6-NTRK3 fusion gene. We report 3 cases of MASC involving the thyroid gland without clinical evidence of a salivary gland or breast primary; the clinico-pathologic characteristics are reviewed. Assessment for rearrangement of the ETV6 (12p13) locus was conducted by fluorescence in situ hybridization (FISH) on representative FFPE sections using an ETV6 break apart probe (Abbott Molecular, Des Plaines, IL, USA)...
July 11, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27284971/analysis-of-monofluoroacetic-acid-in-urine-by-liquid-chromatography-triple-quadrupole-mass-spectrometry-and-preparation-of-the-positive-sample-by-the-bioconversion-from-monofluoroacetamide-to-monofluoroacetic-acid-in-vitro
#16
Xiao-Min Xu, Zeng-Xuan Cai, Jing-Shun Zhang, Yiping Ren, Jian-Long Han
Whether as a rodenticide or as a natural product, monofluoroacetic acid (FAcOH) may cause poisoning to humans or animals for its high acute toxicity. Urine is one of the most typical specimens for forensic diagnosis when poisoning case about FAcOH happens. The positive sample containing FAcOH plays a key role for the development of an accurate and reliable analytical method. The bioconversion from monofluoroacetamide (FAcNH2) to FAcOH in urine in vitro was studied for the preparation of positive urine sample containing FAcOH without standard spiking or animal experiment...
August 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27279268/radiation-exposure-in-patients-treated-with-endovascular-aneurysm-repair-what-is-the-risk-of-cancer-and-can-we-justify-treating-younger-patients
#17
Thomas Nyheim, Lars E Staxrud, Jørgen J Jørgensen, Kristin Jensen, Hilde M Olerud, Gunnar Sandbæk
BACKGROUND: Endovascular aneurysm repair (EVAR) is becoming the mainstay treatment of abdominal aortic aneurisms (AAA). The postoperative follow-up regime includes a lifelong series of CT angiograms (CTAs) at different intervals in addition to EVAR, which will confer significant cumulative radiation exposure over time. PURPOSE: To examine the impact of age and follow-up regime over time on cumulative radiation exposure and attributable cancer risk after EVAR. MATERIAL AND METHODS: We calculated a mean effective dose (ED) for the EVAR procedure, CTA, and plain abdominal X-rays (PAX)...
June 8, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27121110/rhus-verniciflua-stokes-rvs-and-butein-induce-apoptosis-of-paclitaxel-resistant-skov-3-pax-ovarian-cancer-cells-through-inhibition-of-akt-phosphorylation
#18
Hyeong Sim Choi, Min Kyoung Kim, Youn Kyung Choi, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko
BACKGROUND: Rhus verniciflua Stokes (RVS) belongs to the Anacardiaceae family and traditionally used for cancer treatment. RVS and butein, a major compound of RVS, were known to induce apoptosis via AKT inhibition in cancer cells. Thus, in this study, we investigated the effect of RVS and its derivative compounds (fisetin, quercetin, butein) on cell death in SKOV-3/PAX cells. METHODS: The 80 % ethanol extract of RVS and its derivative compounds (fisetin, quercetin, butein) were prepared...
April 27, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27080979/renin-angiotensin-aldosterone-system-inhibition-increases-podocyte-derivation-from-cells-of-renin-lineage
#19
Julia Lichtnekert, Natalya V Kaverina, Diana G Eng, Kenneth W Gross, J Nathan Kutz, Jeffrey W Pippin, Stuart J Shankland
Because adult podocytes cannot proliferate and are therefore unable to self-renew, replacement of these cells depends on stem/progenitor cells. Although podocyte number is higher after renin-angiotensin-aldosterone system (RAAS) inhibition in glomerular diseases, the events explaining this increase are unclear. Cells of renin lineage (CoRL) have marked plasticity, including the ability to acquire a podocyte phenotype. To test the hypothesis that RAAS inhibition partially replenishes adult podocytes by increasing CoRL number, migration, and/or transdifferentiation, we administered tamoxifen to Ren1cCreERxRs-tdTomato-R CoRL reporter mice to induce permanent labeling of CoRL with red fluorescent protein variant tdTomato...
December 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27038421/mild-heat-stress-enhances-differentiation-and-proliferation-of-japanese-quail-myoblasts-and-enhances-slow-muscle-fiber-characteristics
#20
Y M Choi, P R Chen, S Shin, J Zhang, S Hwang, K Lee
The objective of this study was to investigate the effect of mild heat stress on muscle fiber hyperplastic and hypertrophic growth in quail primary myogenic cells to better understand the mechanisms leading to increased skeletal muscle development in avian embryos incubated at a higher temperature. Compared to control cultures maintained at 37°C, incubation at 39°C enhanced myotube length (P < 0.01) and diameter (P < 0.001) at 3 days after differentiation (D3). This enlargement of the myotubes incubated at 39°C can be explained by differences in the fusion index (56...
August 1, 2016: Poultry Science
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