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https://www.readbyqxmd.com/read/28342648/the-first-clinical-implementation-of-a-real-time-six-degree-of-freedom-target-tracking-system-during-radiation-therapy-based-on-kilovoltage-intrafraction-monitoring-kim
#1
Doan Trang Nguyen, Ricky O'Brien, Jung-Ha Kim, Chen-Yu Huang, Lee Wilton, Peter Greer, Kimberley Legge, Jeremy T Booth, Per Rugaard Poulsen, Jarad Martin, Paul J Keall
PURPOSE: We present the first clinical implementation of a real-time six-degree of freedom (6DoF) Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. The method was applied to measure and correct for target motion during stereotactic body radiotherapy (SBRT) for prostate cancer. METHODS: Patient: A patient with prostate adenocarcinoma undergoing SBRT with 36.25Gy, delivered in 5 fractions was enrolled in the study...
March 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28335794/tumor-motion-changes-in-stereotactic-body-radiotherapy-for-liver-tumors-an-evaluation-based-on-four-dimensional-cone-beam-computed-tomography-and-fiducial-markers
#2
Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Osamu Ikeda, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Yasuyuki Yamashita, Natsuo Oya, Fujio Araki
BACKGROUND: For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether liver tumor motion at the planning simulation represents liver tumor motion during SBRT, and estimated inter- and intrafractional tumor motion changes in patients undergoing liver SBRT. METHODS: Ten patients underwent four-dimensional cone-beam computed tomography (4D-CBCT) image-guided liver SBRT with abdominal compression (AC) and fiducial markers...
March 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28334695/how-the-embryonic-chick-brain-twists
#3
Zi Chen, Qiaohang Guo, Eric Dai, Nickolas Forsch, Larry A Taber
During early development, the tubular embryonic chick brain undergoes a combination of progressive ventral bending and rightward torsion, one of the earliest organ-level left-right asymmetry events in development. Existing evidence suggests that bending is caused by differential growth, but the mechanism for the predominantly rightward torsion of the embryonic brain tube remains poorly understood. Here, we show through a combination of in vitro experiments, a physical model of the embryonic morphology and mechanics analysis that the vitelline membrane (VM) exerts an external load on the brain that drives torsion...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28333175/left-right-pain-asymmetry-with-injectable-cosmetic-treatments-for-the-face
#4
Jacobus Johannes Fouché, Jani Adriaan Jochem Van Loghem, Job Thuis, Linda Marije De Heer, Martijn G H van Oijen
Background: Pain is processed and experienced differently on the left (L) and right (R) sides of the body; however, L/R pain asymmetry with cosmetic treatments of the face has not been evaluated. Objectives: The authors compared patient ratings of L/R facial pain during and immediately after injectable cosmetic treatments. Methods: In this cross-sectional multicenter pragmatic study, pain levels were evaluated for 302 patients who underwent facial treatments with botulinum toxin (BTX) and/or impermanent soft-tissue filler (STF)...
January 27, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28325619/effects-of-online-cone-beam-computed-tomography-with-active-breath-control-in-determining-planning-target-volume-during-accelerated-partial-breast-irradiation
#5
Y Li, R Zhong, X Wang, P Ai, F Henderson, N Chen, F Luo
PURPOSE: To test if active breath control during cone-beam computed tomography (CBCT) could improve planning target volume during accelerated partial breast radiotherapy for breast cancer. METHODS: Patients who were more than 40 years old, underwent breast-conserving dissection and planned for accelerated partial breast irradiation, and with postoperative staging limited to T1-2 N0 M0, or postoperative staging T2 lesion no larger than 3cm with a negative surgical margin greater than 2mm were enrolled...
March 18, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28324950/a-preliminary-evaluation-of-myoelectrical-energy-distribution-of-the-front-neck-muscles-in-pharyngeal-phase-during-normal-swallowing
#6
Mingxing Zhu, Wanzhang Yang, Oluwarotimi Williams Samuel, Yun Xiang, Jianping Huang, Haiqing Zou, Guanglin Li
Pharyngeal phase is a central hub of swallowing in which food bolus pass through from the oral cavity to the esophageal. Proper understanding of the muscular activities in the pharyngeal phase is useful for assessing swallowing function and the occurrence of dysphagia in humans. In this study, high-density (HD) surface electromyography (sEMG) was used to study the muscular activities in the pharyngeal phase during swallowing tasks involving three healthy male subjects. The root mean square (RMS) of the HD sEMG data was computed by using a series of segmented windows as myoelectrical energy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324752/vertical-ground-reaction-force-during-standing-and-walking-are-they-related-to-bone-mineral-density-left-right-asymmetries
#7
Marina Brozgol, Mira Arbiv, Anat Mirelman, Talia Herman, Jeffrey M Hausdorff, Nachum Vaisman
Osteoporosis is a systemic skeletal disease that is characterized by reduced bone mass, deterioration of bone tissue and skeletal fragility. The purpose of the current study was to determine whether asymmetrical femur bone mineral density (BMD) is associated with asymmetrical gait and standing. We compared measures of gait and standing asymmetry in subjects with (n=38) and without (n=11) significant left-right differences in BMD. Participants walked for 72m at their comfortable speed and stood quietly for 60s while outfitted with pressure-sensitive insoles...
March 7, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28320954/cerberus-nodal-lefty-pitx-signaling-cascade-controls-left-right-asymmetry-in-amphioxus
#8
Guang Li, Xian Liu, Chaofan Xing, Huayang Zhang, Sebastian M Shimeld, Yiquan Wang
Many bilaterally symmetrical animals develop genetically programmed left-right asymmetries. In vertebrates, this process is under the control of Nodal signaling, which is restricted to the left side by Nodal antagonists Cerberus and Lefty. Amphioxus, the earliest diverging chordate lineage, has profound left-right asymmetry as a larva. We show that Cerberus, Nodal, Lefty, and their target transcription factor Pitx are sequentially activated in amphioxus embryos. We then address their function by transcription activator-like effector nucleases (TALEN)-based knockout and heat-shock promoter (HSP)-driven overexpression...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28320555/a-population-based-statistical-model-for-daily-geometric-variations-in-the-thorax
#9
Yenny Z Szeto, Marnix G Witte, Marcel van Herk, Jan-Jakob Sonke
PURPOSE: To develop a population based statistical model of the systematic interfraction geometric variations between the planning CT and first treatment week of lung cancer patients for inclusion as uncertainty term in future probabilistic planning. MATERIALS AND METHODS: Deformable image registrations between the planning CT and first week CBCTs of 235 lung cancer patients were used to generate deformation vector fields (DVFs) representing the geometric variations of lung cancer patients...
March 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28320428/a-topology-based-method-to-mitigate-the-dosimetric-uncertainty-caused-by-the-positional-variation-of-the-boost-volume-in-breast-conservative-radiotherapy
#10
Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin, An-Cheng Shiau
BACKGROUND: To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the simultaneous integrated boost (SIB) modulated technique. However, the position of tumor bed kept changing during the treatment course as the treatment position was aligned to bony anatomy. This study aimed to analyze the positional uncertainties between bony anatomy and tumor bed, and a topology-based approach was derived to stratify patients with high variation in tumor bed localization...
March 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28314520/interaction-between-postural-asymmetry-and-visual-feedback-effects-in-undisturbed-upright-stance-control-in-healthy-adults
#11
Patrice R Rougier, Samir Boudrahem
OBJECTIVES: The technique of additional visual feedback has been shown to significantly decrease the center of pressure (CP) displacements of a standing subject. Body-weight asymmetry is known to increase postural instability due to difficulties in coordinating the reaction forces exerted under each foot and is often a cardinal feature of various neurological and traumatic diseases. To examine the possible interactions between additional visual feedback and body-weight asymmetry effects, healthy adults were recruited in a protocol with and without additional visual feedback, with different levels of body-weight asymmetry...
March 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28301694/bioethics-and-populism-how-should-our-field-respond
#12
Mildred Z Solomon, Bruce Jennings
Across the world, an authoritarian and exclusionary form of populism is gaining political traction. Historically, some populist movements have been democratic and based on a sense of inclusive justice and the common good. But the populism on the rise at present speaks and acts otherwise. It is challenging constitutional democracies. The polarization seen in authoritarian populism goes beyond the familiar left-right political spectrum and generates disturbing forms of extremism, including the so-called alternative right in the United States and similar ethnic and nationalistic political movements in other countries...
March 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28301441/predictors-of-linear-and-multidirectional-acceleration-in-elite-soccer-players
#13
Northeast Jonathan, M Russell, D Shearer, C Cook, L Kilduff
Linear and multidirectional acceleration underpins success in professional soccer match-play. However, the physical qualities that determine these performance indicators are poorly understood in elite players. English Premier League players (n=26) performed isometric mid-thigh pulls (IMTP), bilateral and unilateral drop jumps (DJ; from 40 and 20 cm, respectively), bilateral and unilateral countermovement jumps (CMJ) and assessments of linear (5-, 10-, 20-m) and multidirectional (left/right pre-planned and reactive) acceleration...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28301433/a-comparison-of-bilateral-muscular-imbalance-ratio-calculations-using-functional-tests
#14
Theodoros M Bampouras, Susan Dewhurst
Bilateral muscular imbalance can increase the risk of injury and negatively impact sporting performance. Bilateral muscular imbalances are typically calculated as ((side 1-side 2)/reference value) x 100, to provide a percentage value of the difference between limbs. Using different numerator (right-left or strong-weak) or reference values (left, right, strong, weak, average of the two) could mask or inflate the true difference value. The present study aimed to compare the bilateral muscular imbalance ratio calculations, using the absolute difference between limbs as the numerator and the five different options as reference values...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28297982/configurational-and-energy-landscape-in-one-dimensional-coulomb-systems
#15
Lucas Varela, Gabriel Téllez, Emmanuel Trizac
We study a one-dimensional Coulomb system, where two charged colloids are neutralized by a collection of point counterions, with global neutrality. With temperature being given, two situations are addressed: Either the colloids are kept at fixed positions (canonical ensemble) or the force acting on the colloids is fixed (isobaric-isothermal ensemble). The corresponding partition functions are worked out exactly, in view of determining which arrangement of counterions is optimal. How many counterions should be in the confined segment between the colloids? For the remaining ions outside, is there a left-right symmetry breakdown? We evidence a cascade of transitions as system size is varied in the canonical treatment or as pressure is increased in the isobaric formulation...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297922/eigenvector-statistics-of-the-product-of-ginibre-matrices
#16
Zdzisław Burda, Bartłomiej J Spisak, Pierpaolo Vivo
We develop a method to calculate left-right eigenvector correlations of the product of m independent N×N complex Ginibre matrices. For illustration, we present explicit analytical results for the vector overlap for a couple of examples for small m and N. We conjecture that the integrated overlap between left and right eigenvectors is given by the formula O=1+(m/2)(N-1) and support this conjecture by analytical and numerical calculations. We derive an analytical expression for the limiting correlation density as N→∞ for the product of Ginibre matrices as well as for the product of elliptic matrices...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297444/surface-imaging-laser-positioning-or-volumetric-imaging-for-breast-cancer-with-nodal-involvement-treated-by-helical-tomotherapy
#17
Frederik Crop, David Pasquier, Amandine Baczkiewic, Julie Doré, Lena Bequet, Emeline Steux, Anne Gadroy, Jacqueline Bouillon, Clement Florence, Laurence Muszynski, Mathilde Lacour, Eric Lartigau
A surface imaging system, Catalyst (C-Rad), was compared with laser-based positioning and daily mega voltage computed tomography (MVCT) setup for breast patients with nodal involvement treated by helical TomoTherapy. Catalyst-based positioning performed better than laser-based positioning. The respective modalities resulted in a standard deviation (SD), 68% confidence interval (CI) of positioning of left-right, craniocaudal, anterior-posterior, roll: 2.4 mm, 2.7 mm, 2.4 mm, 0.9° for Catalyst positioning, and 6...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297332/impact-of-incorporating-visual-biofeedback-in-4d-mri
#18
David T To, Joshua P Kim, Ryan G Price, Indrin J Chetty, Carri K Glide-Hurst
Precise radiation therapy (RT) for abdominal lesions is complicated by respiratory motion and suboptimal soft tissue contrast in 4D CT. 4D MRI offers improved contrast although long scan times and irregular breathing patterns can be limiting. To address this, visual biofeedback (VBF) was introduced into 4D MRI. Ten volunteers were consented to an IRB-approved protocol. Prospective respiratory-triggered, T2-weighted, coronal 4D MRIs were acquired on an open 1.0T MR-SIM. VBF was integrated using an MR-compatible interactive breath-hold control system...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297312/anatomy-based-definition-of-point-a-utilizing-three-dimensional-volumetric-imaging-approach-for-high-dose-rate-hdr-intracavitary-brachytherapy-dose-prescription-when-treating-cervical-cancer-using-limited-resources
#19
Manish K Goyal, D V Rai, Than S Kehwar, Jayanand Manjhi, Bret H Heintz, Kathleen L Shide, Jerry L Barker
This study was designed to determine whether volumetric imaging could identify consistent alternative prescription methods to Manchester/point A when prescribing radiation dose in the treatment of cervical cancer using HDR intracavitary brachytherapy (ICBT). One hundred and twenty-five treatment plans of 25 patients treated for carcinoma of the cervix were reviewed retrospectively. Each patient received 5 fractions of HDR ICBT following initial cisplatin-based pelvic chemoradiation, and radiation dose was originally prescribed to point A (ICRU-38)...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297304/evaluation-of-kidney-motion-and-target-localization-in-abdominal-sbrt-patients
#20
Marcus Sonier, William Chu, Nafisha Lalani, Darby Erler, Patrick Cheung, Renee Korol
The purpose of this study was to evaluate bilateral kidney and target translational/rotational intrafraction motion during stereotactic body radiation therapy treatment delivery of primary renal cell carcinoma and oligometastatic adrenal lesions for patients immobilized in the Elekta BodyFIX system. Bilateral kidney motion was assessed at midplane for 30 patients immobilized in a full-body dual-vacuum-cushion system with two patients immobilized via abdominal compression. Intrafraction motion was assessed for 15 patients using kilovoltage cone-beam computed tomography (kV-CBCT) datasets (n=151) correlated to the planning CT...
November 2016: Journal of Applied Clinical Medical Physics
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