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https://www.readbyqxmd.com/read/29678754/sex-and-age-dependent-effects-of-orexin-1-receptor-blockade-on-open-field-behavior-and-neuronal-activity
#1
Shannon R Blume, Hannah Nam, Sandra Luz, Debra A Bangasser, Seema Bhatnagar
Adolescence is a sensitive and critical period in brain development where psychiatric disorders such as anxiety, depression and post-traumatic stress disorder are more likely to emerge following a stressful life event. Females are two times more likely to suffer from psychiatric disorders than males. Patients with these disorders show alterations in orexins (also called hypocretins), important neuropeptides that regulate arousal, wakefulness and the hypothalamic-pituitary-adrenal axis activity. Little is known on the role of orexins in mediating arousal behaviors in male and female rats during adolescence or adulthood...
April 17, 2018: Neuroscience
https://www.readbyqxmd.com/read/29678169/omega-3-polyunsaturated-fatty-acid-attenuates-the-inflammatory-response-by-modulating-microglia-polarization-through-sirt1-mediated-deacetylation-of-the-hmgb1-nf-%C3%AE%C2%BAb-pathway-following-experimental-traumatic-brain-injury
#2
Xiangrong Chen, Chunnuan Chen, Sining Fan, Shukai Wu, Fuxing Yang, Zhongning Fang, Huangde Fu, Yasong Li
BACKGROUND: Microglial polarization and the subsequent neuroinflammatory response are contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile group box 1 (HMGB1) mediates the activation of the NF-κB pathway, and it is considered to be pivotal in the late neuroinflammatory response. Activation of the HMGB1/NF-κB pathway is closely related to HMGB1 acetylation, which is regulated by the sirtuin (SIRT) family of proteins. Omega-3 polyunsaturated fatty acids (ω-3 PUFA) are known to have antioxidative and anti-inflammatory effects...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29674970/hypothesis-the-psychedelic-ayahuasca-heals-traumatic-memories-via-a-sigma-1-receptor-mediated-epigenetic-mnemonic-process
#3
Antonio Inserra
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N -Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation. Simultaneously, monoamine oxidase inhibitors (MAOIs) also present in Ayahuasca prevent the degradation of DMT. One peculiarity of SIGMAR1 activation and MAOI activity is the reversal of mnemonic deficits in pre-clinical models...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29672441/six-month-follow-up-of-the-injured-trauma-survivor-screen-itss-clinical-implications-and-future-directions
#4
Joshua C Hunt, Samantha A Chesney, Karen Brasel, Terri A deRoon-Cassini
BACKGROUND: The Injured Trauma Survivor Screen (ITSS) has been shown to predict PTSD and depression risk at one-month after traumatic injury. This study explored the ability of the ITSS to predict chronic distress after injury, as well as the impact of combining the ITSS with an additional screening measure. METHOD: Patients were enrolled following admission to a Level 1 trauma center. Baseline measurements were collected during initial hospitalization, and follow-up measures were collected an average of 6...
April 17, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29672082/predicting-ptsd-severity-from-experiences-of-trauma-and-heterosexism-in-lesbian-and-bisexual-women-a-longitudinal-study-of-cognitive-mediators
#5
Emily R Dworkin, Amanda K Gilmore, Michele Bedard-Gilligan, Keren Lehavot, Katarína Guttmannova, Debra Kaysen
Sexual minority women (SMW) are at high risk of trauma exposure and, subsequently, the development of posttraumatic stress disorder (PTSD). The authors extended a theoretical model explaining the higher risk of mental disorders in minority populations to the maintenance and exacerbation of PTSD symptoms among young adult SMW specifically. This study used observational longitudinal data from a sample of 348 trauma-exposed 18- to 25-year-old individuals assigned female sex at birth who identified as either bisexual (60...
April 2018: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29671376/desistance-and-treatment-seeking-among-women-with-substance-use-disorders
#6
Blythe E Rhodes, Nisha C Gottfredson, Lauren M Hill
Addiction rates are rising faster among women than men. However, women with substance use disorders are less likely to enter treatment than males. This study seeks to understand how turning-point events and other maturational processes affect "life course persistent" women's motivations for seeking treatment for their disorder. We conducted semi-structured in-depth interviews with 30 women who were receiving treatment for addiction using thematic analysis. Recurring themes were as follows: experiences of rock-bottom events prior to entering treatment, feeling "sick and tired" in regard to both their physical and mental health, and shifting identities or perceptions of themselves...
April 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29671295/monitoring-the-injured-brain
#7
Anna T Mazzeo, Deepak K Gupta
Traumatic brain injury can be defined as the most complex disease in the most complex organ. When an acute brain injury occurs, several pathophysiological cascades are triggered, leading to further exacerbation of the primary damage. A number of events potentially occurring after TBI can compromise the availability or utilization of energy substrates in the brain, ultimately leading to brain energy crisis. The frequent occurrence of secondary insults in the acute phase after TBI, such as intracranial hypertension, hypotension, hypoxia, hypercapnia, hyperthermia, seizures, can then increase cerebral damage, and adversely affect outcome...
April 18, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29670562/a-non-linear-predictive-model-of-borderline-personality-disorder-based-on-multilayer-perceptron
#8
Nelson M Maldonato, Raffaele Sperandeo, Enrico Moretto, Silvia Dell'Orco
Borderline Personality Disorder is a serious mental disease, classified in Cluster B of DSM IV-TR personality disorders. People with this syndrome presents an anamnesis of traumatic experiences and shows dissociative symptoms. Since not all subjects who have been victims of trauma develop a Borderline Personality Disorder, the emergence of this serious disease seems to have the fragility of character as a predisposing condition. Infect, numerous studies show that subjects positive for diagnosis of Borderline Personality Disorder had scores extremely high or extremely low to some temperamental dimensions (harm Avoidance and reward dependence) and character dimensions (cooperativeness and self directedness)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29669363/couples-facing-the-birth-of-a-newborn-with-a-congenital-anomaly-ptsd-symptoms-in-the-first-year
#9
Francesca Bevilacqua, Francesco Morini, Antonio Zaccara, Chiara De Marchis, Annabella Braguglia, Simonetta Gentile, Pietro Bagolan, Lucia Aite
OBJECTIVE:  The objective of this study was to assess the presence of posttraumatic stress disorder (PTSD) symptoms in parental couples of newborn requiring early surgery at 6 and 12 months after birth. STUDY DESIGN:  A longitudinal study was set up from January 2014 to June 2015. As a measure of PTSD, we used the Italian version of the Impact of Event Scale-Revised (IES-R). RESULTS:  Thirty-four couples form the object of the study...
April 18, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29669185/distinct-trauma-types-in-military-service-members-seeking-treatment-for-posttraumatic-stress-disorder
#10
Brett T Litz, Ateka A Contractor, Charla Rhodes, Katherine A Dondanville, Alexander H Jordan, Patricia A Resick, Edna B Foa, Stacey Young-McCaughan, Jim Mintz, Jeffrey S Yarvis, Alan L Peterson
We examined the frequency of trauma types reported in a cohort of service members seeking treatment for posttraumatic stress disorder (PTSD) and compared symptom profiles between types. In this observational study, 999 service members (9.2% women; Mage = 32.91 years; 55.6% White) were evaluated using a standardized assessment procedure to determine eligibility for clinical trials. Participants were evaluated for DSM-IV-TR-defined PTSD using the PTSD Symptom Scale-Interview; all participants reported a Criterion A event...
April 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29666932/-complex-regional-pain-syndrome-crps-an-update
#11
V Dimova, F Birklein
The acute phase of complex regional pain syndrome (CRPS) is pathophysiologically characterized by an activation of the immune system and its associated inflammatory response. During the course of CRPS, central nervous symptoms like mechanical hyperalgesia, loss of sensation, and body perception disorders develop. Psychological factors such as pain-related anxiety and traumatic events might have a negative effect on the treatment outcome. While the visible inflammatory symptoms improve, the pain often persists...
April 17, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29666570/role-of-caspase-8-and-fas-in-cell-death-after-spinal-cord-injury
#12
REVIEW
Daniel Sobrido-Cameán, Antón Barreiro-Iglesias
Spinal cord injury (SCI) causes the death of neurons and glial cells due to the initial mechanical forces (i.e., primary injury) and through a cascade of secondary molecular events (e.g., inflammation or excitotoxicity) that exacerbate cell death. The loss of neurons and glial cells that are not replaced after the injury is one of the main causes of disability after SCI. Evidence accumulated in last decades has shown that the activation of apoptotic mechanisms is one of the factors causing the death of intrinsic spinal cord (SC) cells following SCI...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29665733/natural-history-predictors-of-outcome-and-effects-of-treatment-in-thoracic-spinal-cord-injury-a-multicenter-cohort-study-from-the-north-american-clinical-trials-network
#13
Jefferson R Wilson, Blessing Jaja, Brian K Kwon, James Guest, James Shields Harrop, Bizhan Aarabi, Christopher Shaffrey, Jetan Badhiwala, Elizabeth Toups, Robert Grossman, Michael G Fehlings
The course, treatment response and recovery potential following acute traumatic spinal cord injury (SCI) have been shown to differ depending on the neurological level of injury. However, there are limited data focused on thoracic-level injuries. A cohort of 86 patients from the prospectively maintained North American Clinical Trials Network (NACTN) SCI registry were identified and studied to characterize the patterns of neurological recovery as well as to determine rates of acute hospital mortality and pulmonary complications...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29661275/preinjury-statin-use-and-thromboembolic-events-in-trauma-a-10-year-retrospective-evaluation
#14
Ryan A McMahon, John L Fletcher, James K Aden, Seth R Holland, Scott T Trexler, Lorne H Blackbourne
BACKGROUND: Traumatic injury is well known to increase the risk of venous thromboembolic events (VTEs), occurring in up to 58% of trauma patients. Statin medications have significant anti-inflammatory properties and have been shown to reduce the risk of VTE. We hypothesized that trauma patients who received statin medication before injury would have a lower incidence of VTE after injury. METHODS: A 10-y retrospective review identified all patients admitted to our trauma service with an injury severity score >9 and an intensive care unit stay of >3 d...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29659210/toward-understanding-sex-differences-in-the-prevalence-of-posttraumatic-stress-disorder-results-from-the-national-epidemiologic-survey-on-alcohol-and-related-conditions
#15
Carlos Blanco, Nicolas Hoertel, Melanie M Wall, Silvia Franco, Hugo Peyre, Yuval Neria, Liat Helpman, Frédéric Limosin
BACKGROUND: It is unclear whether the higher prevalence of posttraumatic stress disorder (PTSD) in women than in men is due to sex differences in the prevalence of the exposure to traumatic events or to differences in vulnerability to traumatic events among those exposed to them. METHODS: We applied mediation and moderated mediation models to a large nationally representative sample of US adults (N = 34,653) drawn from Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions...
March 27, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29658057/combined-effects-of-rat-schwann-cells-and-17%C3%AE-estradiol-in-a-spinal-cord-injury-model
#16
Zeinab Namjoo, Fateme Moradi, Roya Aryanpour, Abbas Piryaei, Mohammad Taghi Joghataei, Yusef Abbasi, Amir Hosseini, Sajad Hassanzadeh, Fatemeh Ranjbar Taklimie, Cordian Beyer, Adib Zendedel
Spinal cord injury (SCI) is a devastating traumatic event which burdens the affected individuals and the health system. Schwann cell (SC) transplantation is a promising repair strategy after SCI. However, a large number of SCs do not survive following transplantation. Previous studies demonstrated that 17β-estradiol (E2) protects different cell types and reduces tissue damage in SCI experimental animal model. In the current study, we evaluated the protective potential of E2 on SCs in vitro and investigated whether the combination of hormonal and SC therapeutic strategy has a better effect on the outcome after SCI...
April 15, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29657096/mother-father-and-child-traumatic-stress-reactions-after-paediatric-burn-within-family-co-occurrence-and-parent-child-discrepancies-in-appraisals-of-child-stress
#17
Marthe R Egberts, Rens van de Schoot, Rinie Geenen, Nancy E E Van Loey
AIM: The current study examined occurrence and within-family associations of traumatic stress reactions after child burn injury, while in the same model addressing the role of parents' own symptoms in their reports of child symptoms. METHODS: One-hundred children (8-18 years old), and their mothers (n=90) and fathers (n=74) were assessed within the first month (T1) and three months (T2) after burn. Parents and children rated child traumatic stress reactions on the Children's Responses to Trauma Inventory (CRTI) and parents rated their own reactions on the Impact of Event Scale (IES)...
April 12, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29655375/association-between-traumatic-stress-load-psychopathology-and-cognition-in-the-philadelphia-neurodevelopmental-cohort
#18
Ran Barzilay, Monica E Calkins, Tyler M Moore, Daniel H Wolf, Theodore D Satterthwaite, J Cobb Scott, Jason D Jones, Tami D Benton, Ruben C Gur, Raquel E Gur
BACKGROUND: Traumatic stressors during childhood and adolescence are associated with psychopathology, mostly studied in the context of post-traumatic stress disorder (PTSD) and depression. We investigated broader associations of traumatic stress exposure with psychopathology and cognition in a youth community sample. METHODS: The Philadelphia Neurodevelopmental Cohort (N = 9498) is an investigation of clinical and neurobehavioral phenotypes in a diverse (56% Caucasian, 33% African American, 11% other) US youth community population (aged 8-21)...
April 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29652647/prevalence-and-predictors-of-ptsd-among-a-college-sample
#19
Shannon E C Usack, Terrell A Hicks, Jessica Bourdon, Christina M Sheerin, Cassie M Overstreet, Kenneth S Kendler, Danielle M Dick, Ananda B Amstadter
OBJECTIVE: This study examined the prevalence and correlates of probable posttraumatic stress disorder (PTSD) in freshman entering college and prospective associations of probable PTSD with additional outcomes. PARTICIPANTS: 2,310 students with data collected from Fall 2014 through Spring 2015. METHODS: Incoming freshman completed a survey assessing for relevant variables at the beginning of fall semester and during the spring semester. RESULTS: Seventy percent of the sample endorsed experiencing at least one potentially traumatic event (PTE)...
April 13, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29651952/special-traumatized-populations-burns-and-hypothermia
#20
Shruti Mehrotra, Amita Misir
It is important for physicians treating children to be aware of unique presentation that require expertise and knowledge. Two areas of importance when caring for traumatized children are Thermal Burn Injuries, and Hypothermia. Burns commonly result in morbidity in children; as such, the appropriate identification of the severity of the burn and appropriate management are integral to minimize the complications of burns during the acute phase. Attention to proper fluid management is paramount. Knowledge of types of solutions to use during Burn treatment is important...
April 11, 2018: Current Pediatric Reviews
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