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https://www.readbyqxmd.com/read/28823092/inhibition-of-p2x7-receptors-improves-outcomes-after-traumatic-brain-injury-in-rats
#1
Xiaofeng Liu, Zhengqing Zhao, Ruihua Ji, Jiao Zhu, Qian-Qian Sui, Gillian E Knight, Geoffrey Burnstock, Cheng He, Hongbin Yuan, Zhenghua Xiang
Traumatic brain injury (TBI) is the leading cause of death and disability for people under the age of 45 years worldwide. Neuropathology after TBI is the result of both the immediate impact injury and secondary injury mechanisms. Secondary injury is the result of cascade events, including glutamate excitotoxicity, calcium overloading, free radical generation, and neuroinflammation, ultimately leading to brain cell death. In this study, the P2X7 receptor (P2X7R) was detected predominately in microglia of the cerebral cortex and was up-regulated on microglial cells after TBI...
August 19, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28822277/the-role-of-anxiety-sensitivity-in-reactivity-to-trauma-cues-in-treatment-seeking-adults-with-substance-use-disorders
#2
R Kathryn McHugh, Kim L Gratz, Matthew T Tull
BACKGROUND: Exposure to traumatic events and posttraumatic stress disorder (PTSD) are common among individuals with substance use disorders (SUDs). Although the presence of trauma exposure and/or PTSD among those with SUDs is associated with a range of negative outcomes, much remains to be understood about the factors contributing to these outcomes. Anxiety sensitivity (the tendency to respond fearfully to the signs and symptoms of anxiety) has been linked to greater PTSD symptoms and the use of substances to cope with PTSD symptoms, and is a promising factor for understanding the negative outcomes associated with co-occurring PTSD and SUDs...
July 31, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28821837/risk-factors-for-chronic-post-traumatic-stress-disorder-development-one-year-after-vaginal-delivery-a-prospective-observational-study
#3
Loïc Sentilhes, Françoise Maillard, Stéphanie Brun, Hugo Madar, Benjamin Merlot, François Goffinet, Catherine Deneux-Tharaux
Our study aimed to assess the prevalence of post-traumatic stress disorder (PTSD) after childbirth one year after vaginal delivery and to identify characteristics of women and deliveries associated with it. Questionnaires were mailed a year after delivery to 1103 women with prospectively collected delivery and postpartum data, including a question on day 2 assessing their experience of childbirth. PTSD was assessed a year later by the Impact of Event and Traumatic Event Scales; 22 women (4.2%, 95%CI 2.7-6.3%) met the PTSD diagnostic criteria and 30 (5...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820172/timing-of-surgery-in-traumatic-globe-dislocation
#4
Md Shahid Alam, Olma Veena Noronha, Bipasha Mukherjee
Traumatic globe dislocation into the maxillary sinus is a rare event and usually associated with a poor visual outcome if not managed appropriately. We report a 45-year-old female patient who presented to the emergency after blunt injury to her face with a door. Initial evaluation revealed nil perception of light and an apparently anophthalmic socket. Neuroimaging revealed large floor and medial wall fracture with dislocation of the globe into the maxillary sinus. The patient underwent exploration with repositioning of the globe and fracture repair...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28819694/thoracic-corpectomy-for-neoplastic-vertebral-bodies-using-a-navigated-lateral-extracavitary-approach-a-single-center-consecutive-case-series-technique-and-analysis
#5
Sebastian Hartmann, Christoph Wipplinger, Anja Tschugg, Pujan Kavakebi, Alexander Örley, Pierre Pascal Girod, Claudius Thomé
Thoracic myelopathy is often caused by vertebral body fractures resulting from neoplastic conditions, traumatic events, or infectious diseases. One of the preferred procedures for treating it is the lateral extracavitary approach (LECA) with single-level or multilevel decompressive corpectomy and reconstruction. The aim of this retrospective study was to analyze the thoracic lateral extracavitary approach with corpectomy using vertebral body replacement systems (VBR-S) and dorsal reconstruction. Twenty-four patients with metastatic or primary lesions of thoracic vertebrae T2-T12 underwent spinal decompression and ventral column reconstruction with correction of spinal deformity via a LECA...
August 17, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28819611/acute-stress-fracture-of-the-pelvis-after-total-hip-arthroplasty-a-case-report
#6
Oluwaseun Akinbo, Vineet Tyagi
INTRODUCTION: Acute hip pain following total hip arthroplasty (THA) could have numerous causes to include stress fracture of the pelvis. Stress fractures of the pelvis are rare and have been reported to involve the medial wall and the pubic ramus. A unique case is presented demonstrating the clinical presentation and management of an acute stress fracture of ilium and anterior column following a THA. CASE REPORT: A 72-year-old man underwent an uncomplicated right THA...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28818733/effects-of-childhood-trauma-exposure-and-cortisol-levels-on-cognitive-functioning-among-breast-cancer-survivors
#7
Charles Kamen, Caroline Scheiber, Michelle Janelsins, Booil Jo, Hanyang Shen, Oxana Palesh
Cognitive functioning difficultiesin breast cancer patients receiving chemotherapy are common, but not all women experience these impairments. Exposure to childhood trauma may impair cognitive functioning following chemotherapy, and these impairments may be mediated by dysregulation of hypothalamic-pituitary-adrenal (HPA) axis function and cortisol slope. This study evaluated the association between childhood trauma exposure, cortisol, and cognition in a sample of breast cancer survivors. 56 women completed measures of trauma exposure (the Traumatic Events Survey), salivary cortisol, and self-reported cognitive functioning (the Functional Assessment of Cancer Therapy - Cognitive)...
August 14, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28818717/the-effect-of-post-traumatic-stress-disorder-on-the-risk-of-developing-prescription-opioid-use-disorder-results-from-the-national-epidemiologic-survey-on-alcohol-and-related-conditions-iii
#8
Ahmed N Hassan, Bernard Le Foll, Sameer Imtiaz, Jürgen Rehm
OBJECTIVE: To evaluate the effect of baseline post-traumatic stress disorder (PTSD) and each symptoms cluster on the risk of developing opioid use disorder (OUD) in those exposed to opioid painkillers and to assess the effect of comorbid PTSD and OUD on functioning, OUD severity, and treatment seeking compared with individuals with OUD only. METHODS: We obtained data from 4025 individuals exposed to opioid painkillers from the National Epidemiologic Survey on Alcohol and Related Conditions III...
August 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28818702/the-effects-of-cannabinoid-receptors-activation-and-glucocorticoid-receptors-deactivation-in-the-amygdala-and-hippocampus-on-the-consolidation-of-a-traumatic-event
#9
Noa Shoshan, Irit Akirav
Ample evidence demonstrates that fear learning contributes significantly to many anxiety pathologies including post-traumatic stress disorder (PTSD). The endocannabinoid (eCB) system may offer therapeutic benefits for PTSD and it is a modulator of the hypothalamic pituitary adrenal (HPA) axis. Here we compared the separated and combined effects of blocking glucocorticoid receptors (GRs) using the GR antagonist RU486 and enhancing CB1r signaling using the CB1/2 receptor agonist WIN55,212-2 in the CA1 and basolateral amygdala (BLA) on the consolidation of traumatic memory...
August 14, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28816545/role-of-diffusion-tensor-imaging-in-the-diagnosis-and-management-of-post-traumatic-anosmia
#10
Lilla Bonanno, Silvia Marino, Simona De Salvo, Rosella Ciurleo, Antonio Costa, Daniele Bruschetta, Demetrio Milardi, Galletti Francesco, Placido Bramanti, Fabrizia Caminiti
INTRODUCTION: Anosmia is a possible complication of Traumatic Brain Injury (TBI). Psychometric and electrophysiological methods of olfaction measure and Magnetic Resonance Imaging (MRI) are the tools to evaluate the post-traumatic olfactory loss. Diffusion Tensor Imaging (DTI) provides useful data for a better understanding of etiopathogenesis TBI-related anosmia, in particular the loss of neural connections and their eventual recovery over time. MATERIALS AND METHODS: This study describes a case of TBI-related anosmia...
August 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28813294/weathering-the-storm-the-impact-of-trauma-on-romantic-relationships
#11
REVIEW
Emma M Marshall, Roeline G Kuijer
The current paper reviews the recent literature examining the impact of trauma on romantic relationships. We introduce the Dyadic Responses to Trauma (DRT) Model as a framework for organizing existing research and guiding future research. A traumatic event affects romantic relationships for the better or for the worse depending on the diverse trauma-related experiences people can have, influencing the way partners interact with each other and ultimately the quality of the relationship. In addition, recent research demonstrates how romantic partners can demonstrate resiliency in spite of a negative trauma experience depending on how they interpret and cope with the experience individually and as a couple...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28812415/quality-of-life-after-orbito-facial-trauma
#12
Gitanjali Sharma, Apjit Kaur
In the wake of high incidence of orbito-facial trauma, there has been a growing need to assess not only the visual outcome, but also the psychological impact of the traumatic event. This is a single questionnaire based evaluation of 100 consecutive patients with orbito-facial trauma (blow-out and Le fort type II and III fractures) at six months of trauma. 84% of the patients had a NEI VFQ- 25 score of less than 50, with 49% having a score less than 25, reflecting the grim impact the trauma has on the quality of life...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28810445/enduring-somatic-threat-perceptions-and-post-traumatic-stress-disorder-symptoms-in-survivors-of-cardiac-events
#13
Laura Meli, Carmela Alcántara, Jennifer A Sumner, Brendan Swan, Bernard P Chang, Donald Edmondson
Post-traumatic stress disorder due to acute cardiovascular events may be uniquely defined by enduring perceptions of somatic threat. We tested whether post-traumatic stress disorder at 1 month post-acute coronary syndrome indeed required both high peritraumatic threat during the acute coronary syndrome and ongoing cardiac threat perceptions. We assessed peritraumatic threat during emergency department enrollment of 284 patients with a provisional acute coronary syndrome diagnosis and cardiac threat perceptions and post-traumatic stress disorder symptoms 1 month post-discharge...
April 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28806206/chronic-pain-and-associated-factors-in-india-and-nepal-a-pilot-study-of-the-vanderbilt-global-pain-survey
#14
Jenna L Walters, Kelly Baxter, Hannah Chapman, Tracy Jackson, Adinarayanan Sethuramachandran, Marcus Couldridge, Hem Raj Joshi, Pankaj Kundra, Xulei Liu, Divya Nair, Bonnie Sullivan, Matthew S Shotwell, Ryan J Jense, Nicholas J Kassebaum, K A Kelly McQueen
BACKGROUND: Evaluation and treatment of chronic pain worldwide are limited by the lack of standardized assessment tools incorporating consistent definitions of pain chronicity and specific queries of known social and psychological risk factors for chronic pain. The Vanderbilt Global Pain Survey (VGPS) was developed as a tool to address these concerns, specifically in the low- and middle-income countries where global burden is highest. METHODS: The VGPS was developed using standardized and cross-culturally validated metrics, including the Brief Pain Inventory and World Health Organization Disability Assessment Scale, as well as the Pain Catastrophizing Scale, the Fibromyalgia Survey Questionnaire along with queries about pain attitudes to assess the prevalence of chronic pain and disability along with its psychosocial and emotional associations...
August 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28805719/factors-affecting-depressive-symptoms-among-north-korean-adolescent-refugees-residing-in-south-korea
#15
Subin Park, Minji Lee, Jin Yong Jeon
We examined factors affecting the depressive symptoms and the relationship between depression and quality of life among 131 North Korean adolescent refugees aged 12-24 years. We compared sociodemographic, social, and individual characteristics and perceived the quality of life between participants with and without depression. Thirty-seven refugees (28.2%) had clinically significant depressive symptoms. The refugees with depression were younger (t = 2.67; p = 0.009), more likely to be male (χ² = 6.98; p = 0...
August 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28805168/9-11-related-ptsd-among-highly-exposed-populations-a-systematic-review-15-years-after-the-attack
#16
A Lowell, B Suarez-Jimenez, L Helpman, X Zhu, A Durosky, A Hilburn, F Schneier, R Gross, Y Neria
BACKGROUND: The 11 September 2001 (9/11) attacks were unprecedented in magnitude and mental health impact. While a large body of research has emerged since the attacks, published reviews are few, and are limited by an emphasis on cross-sectional research, short time frame, and exclusion of treatment studies. Additionally, to date, there has been no systematic review of available longitudinal information as a unique data set. Consequently, knowledge regarding long-term trajectories of 9/11-related post-traumatic stress disorder (PTSD) among highly exposed populations, and whether available treatment approaches effectively address PTSD within the context of mass, man-made disaster, remains limited...
August 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28804594/does-trauma-event-type-matter-in-the-assessment-of-traumatic-load
#17
Daniela Conrad, Sarah Wilker, Anett Pfeiffer, Birke Lingenfelder, Tracie Ebalu, Hartmut Lanzinger, Thomas Elbert, Iris-Tatjana Kolassa, Stephan Kolassa
Background: The likelihood of developing Posttraumatic Stress Disorder (PTSD) depends on the interaction of individual risk factors and cumulative traumatic experiences. Hence, the identification of individual susceptibility factors warrants precise quantification of trauma exposure. Previous research indicated that some traumatic events may have more severe influences on mental health than others; thus, the assessment of traumatic load may be improved by weighting event list items rather than calculating the simple sum score...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/28803030/neurofeedback-sham-neurofeedback-and-cognitive-behavioural-group-therapy-in-adults-with-attention-deficit-hyperactivity-disorder-a-triple-blind-randomised-controlled-trial
#18
Michael Schönenberg, Eva Wiedemann, Alexander Schneidt, Jonathan Scheeff, Alexander Logemann, Philipp M Keune, Martin Hautzinger
BACKGROUND: Many studies suggest that electroencephalographic (EEG) neurofeedback might be beneficial in the treatment of attention-deficit hyperactivity disorder (ADHD). However, numbers of well controlled studies are low and neurofeedback techniques are regarded as highly controversial. The present trial examined the efficacy (compared with sham neurofeedback) and efficiency (compared with meta-cognitive therapy) of a standard EEG neurofeedback protocol in adults with ADHD. METHODS: We did a concurrent, triple-blind, randomised, controlled trial using authorised deception in adults with ADHD from one centre (University of Tübingen) in Tübingen, Germany...
August 9, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28802537/psychosocial-reactions-to-upper-extremity-limb-salvage-a-cross-sectional-study
#19
Lindsay Sposato, Kathleen Yancosek, Josh Lospinoso, Jill Cancio
STUDY DESIGN: Descriptive cross-sectional survey study. INTRODUCTION: Limb salvage spares an extremity at risk for amputation after a major traumatic injury. Psychosocial recovery for individuals with lower extremity limb salvage has been discussed in the literature. However, to date, psychosocial reactions for individuals with upper extremity (UE) limb salvage have not been examined. PURPOSE OF THE STUDY: To determine which factors may influence psychosocial adaptation to UE limb salvage...
August 9, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28801484/predicting-outcomes-in-traumatic-out-of-hospital-cardiac-arrest-the-relevance-of-utstein-factors
#20
Ben Beck, Janet E Bray, Peter Cameron, Lahn Straney, Emily Andrew, Stephen Bernard, Karen Smith
BACKGROUND: Given low survival rates in cases of traumatic out-of-hospital cardiac arrest (OHCA), there is a need to identify factors associated with outcomes. We aimed to investigate Utstein factors associated with achieving return of spontaneous circulation (ROSC) and survival to hospital in traumatic OHCA. METHODS: The Victorian Ambulance Cardiac Arrest Registry (VACAR) was used to identify cases of traumatic OHCA that received attempted resuscitation and occurred between July 2008 and June 2014...
August 11, 2017: Emergency Medicine Journal: EMJ
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