keyword
https://read.qxmd.com/read/38530076/in-situ-phase-transformation-forming-a-bicontinuous-ni-co-ti-and-al-oxide-li-2-co-3-interpenetrating-network-electrolyte-for-solid-oxide-fuel-cells
#21
JOURNAL ARTICLE
Yanyan Liu, Xiaochun Ma, Hongjun Ye, Jitong Yan, Yongfu Tang, Shaozheng Ji
Designing heterogeneous electrolytes with superior interface charge transfer is promising for low-temperature solid oxide fuel cells (LT-SOFCs). However, a rational construction with optimal interfaces to maximize ionic conduction remains a challenge. Here an in situ phase-transformation strategy is demonstrated to prepare a highly conductive heterogeneous electrolyte. A pristine LiNiO2 -TiO2 nanocomposite precursor undergoes chemical reactions and phase-transformation upon heating and feeding H2 , destroying the original phases, and forming new species, including an amorphous Li2 CO3 scaffold within a (Ni, Co, Al, and Ti)-oxide (NCAT) matrix...
March 26, 2024: Small
https://read.qxmd.com/read/38530039/hydrogen-bonded-organic-framework-supporting-atomic-bi-n2o2%C3%A2-sites-for-high-efficiency-electrocatalytic-co2%C3%A2-reduction
#22
JOURNAL ARTICLE
Changli Wang, Zunhang Lv, Yarong Liu, Rui Liu, Caiting Sun, Jinming Wang, Liuhua Li, Xiangjian Liu, Xiao Feng, Wenxiu Yang, Bo Wang
Single atomic catalysts (SACs) offer a superior platform for studying the structure-activity relationships during electrocatalytic CO2 reduction reaction (CO2RR). Yet challenges still exist to obtain well-defined and novel site configuration owing to the uncertainty of functional framework-derived SACs through calcination. Herein, a novel Bi-N2O2 site supported on the (1 1 0) plane of hydrogen-bonded organic framework (HOF) is reported directly for CO2RR. In flow cell, the target catalyst Bi1-HOF maintains a faradaic efficiency (FE) HCOOH of over 90% at a wide potential window of 1...
March 26, 2024: Angewandte Chemie
https://read.qxmd.com/read/38529961/right-ventricular-scalloping-index-as-cmr-derived-marker-for-diagnosis-of-arrhythmogenic-right-ventricular-cardiomyopathy
#23
JOURNAL ARTICLE
Ko-Ying Huang, Fa-Po Chung, Chao-Yu Guo, Jui-Han Chiu, Ling Kuo, Ying-Chi Lee, Ching-Yao Weng, Ying-Yueh Chang, Yenn-Jiang Lin, Chun-Ku Chen
BACKGROUND: The cardiac magnetic resonance (CMR) evaluation of right ventricular (RV) morphologic abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) is subjective. Here we aimed to use a quantitative index, the right ventricular scalloping index (RVSI), to standardize the measurement of RV free wall scalloping and aid in the imaging diagnosis. METHODS: We retrospectively included 15 patients with definite ARVC and 45 age- and sex-matched patients with idiopathic right ventricular outflow tract ventricular arrhythmia (RVOT-VA) as controls...
March 26, 2024: Journal of the Chinese Medical Association: JCMA
https://read.qxmd.com/read/38529947/a-novel-machine-learning-algorithm-selects-proteome-signature-to-specifically-identify-cancer-exosomes
#24
JOURNAL ARTICLE
Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
Non-invasive early cancer diagnosis remains challenging due to the low sensitivity and specificity of current diagnostic approaches. Exosomes are membrane-bound nanovesicles secreted by all cells that contain DNA, RNA, and proteins that are representative of the parent cells. This property, along with the abundance of exosomes in biological fluids makes them compelling candidates as biomarkers. However, a rapid and flexible exosome-based diagnostic method to distinguish human cancers across cancer types in diverse biological fluids is yet to be defined...
March 26, 2024: ELife
https://read.qxmd.com/read/38529943/nir-ii-absorbing-tmb-derivative-for-1064-nm-excited-photothermal-immunoassay
#25
JOURNAL ARTICLE
Henglin Liu, Xiao Zhang, Xianming Li, Peng Wu
Materials exhibiting strong absorption in the NIR-II region are appealing for photothermal conversion-based imaging, diagnosis, and therapy, due to better thermal effect and decreased absorption of water in such a region. 3,3',5,5'-Tetramethylbenzidine (TMB), the typical substrate in ELISA, has been explored in photothermal immunoassay, since its oxidation product (oxTMB) is photothermally active in the NIR region. However, its absorption at 1064 nm (the most often used laser wavelength in photothermal studies) is not appreciable, thus limiting the assay sensitivity...
March 26, 2024: Analytical Chemistry
https://read.qxmd.com/read/38529920/phenylboronic-acid-modification-based-novel-dumbbell-shaped-au-ag-nanorod-sers-substrates-for-ultrasensitive-detection-of-so-4-2
#26
JOURNAL ARTICLE
Kang Shen, Caili Bi, Haifan Yang, Miaowen Xu, Lili Huang, Youwei Wang
Based on the coordination principle of Lewis acids, a 4-mercaptophenylboronic acid (4-MPBA)-modified novel dumbbell-shaped Au-Ag nanorod (4-MPBA@DS Au-AgNR) substrate was developed, which could be combined with the surface-enhanced Raman scattering (SERS) technique to detect SO4 2- with high sensitivity and specificity. DS Au-AgNRs synthesized in this study with a dumbbell-shaped structure were verified by finite-difference time domain (FDTD) simulation to be capable of stimulating strong localized electromagnetic enhancement (EM) at nano-edge and gap, generating a large number of "hot spots" exhibiting excellent SERS performance...
March 26, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38529913/evaluation-of-open-source-large-language-models-for-metal-organic-frameworks-research
#27
JOURNAL ARTICLE
Xuefeng Bai, Yabo Xie, Xin Zhang, Honggui Han, Jian-Rong Li
Along with the development of machine learning, deep learning, and large language models (LLMs) such as GPT-4 (GPT: Generative Pre-Trained Transformer), artificial intelligence (AI) tools have been playing an increasingly important role in chemical and material research to facilitate the material screening and design. Despite the exciting progress of GPT-4 based AI research assistance, open-source LLMs have not gained much attention from the scientific community. This work primarily focused on metal-organic frameworks (MOFs) as a subdomain of chemistry and evaluated six top-rated open-source LLMs with a comprehensive set of tasks including MOFs knowledge, basic chemistry knowledge, in-depth chemistry knowledge, knowledge extraction, database reading, predicting material property, experiment design, computational scripts generation, guiding experiment, data analysis, and paper polishing, which covers the basic units of MOFs research...
March 26, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38529877/from-nmr-to-ai-designing-a-novel-chemical-representation-to-enhance-machine-learning-predictions-of-physicochemical-properties
#28
JOURNAL ARTICLE
Arkadiusz Leniak, Wojciech Pietruś, Rafał Kurczab
A novel approach to the utilization of nuclear magnetic resonance (NMR) spectroscopy data in the prediction of logD through machine learning algorithms is shown. In the analysis, a data set of 754 chemical compounds, organized into 30 clusters, was evaluated using advanced machine learning models, such as Support Vector Regression (SVR), Gradient Boosting, and AdaBoost, and comprehensive validation and testing methods were employed, including 10-fold cross-validation, bootstrapping, and leave-one-out. The study revealed the superior performance of the Bucket Integration method for dimensionality reduction, consistently yielding the lowest root mean square error (RMSE) across all data sets and normalization schemes...
March 26, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38529845/predicting-anti-covid-19-potential-in-silico-analysis-of-mauritine-compound-from-ziziphus-spina-christi-as-a-promising-papain-like-protease-plpro-inhibitor
#29
JOURNAL ARTICLE
Taufik Muhammad Fakih, Fitrianti Darusman, Riry Apriliani, Syifa Prahayati, Dwi Syah Fitra Ramadhan, Aulia Fikri Hidayat, Aden Dhana Rizkita, Tegar Achsendo Yuniarta
The COVID-19 pandemic caused by the SARS-CoV-2 virus, recognized by the World Health Organization (WHO), has led to 164,523,894 confirmed cases and 3,412,032 deaths globally as of May 20, 2021. SARS-CoV-2 encodes crucial proteases for its replication cycle, including the papain-like protease (PLpro), presenting a potential target for developing COVID-19 treatments. Mauritine, a cyclopeptide alkaloid found in the Ziziphus-spina christi plant, exhibits antiviral properties and was investigated for its affinity and toxicity towards PLpro using molecular docking through MGLTools 1...
March 26, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38529785/not-exclusively-the-activity-but-the-sweet-spot-a-dehydrogenase-point-mutation-synergistically-boosts-activity-substrate-tolerance-thermal-stability-and-yield
#30
JOURNAL ARTICLE
Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
Catalytic activity is undoubtedly a key focus in enzyme engineering. The complicated reaction conditions hinder some enzymes from industrialization even though they have relatively promising activity. This has occurred to some dehydrogenases. Hydroxysteroid dehydrogenases (HSDHs) specifically catalyze the conversion between hydroxyl and keto groups, and hold immense potential in the synthesis of steroid medicines. We underscored the importance of 7α-HSDH activity, and analyzed the overall robustness and underlying mechanisms...
March 26, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38529737/straightforward-creation-of-multishell-hollow-hybrids-for-an-integrated-metabolic-monitoring-system-in-disease-management
#31
JOURNAL ARTICLE
Man Zhang, Fangying Shi, Yijie Chen, Chenyu Yang, Xiangmin Zhang, Chunhui Deng, Nianrong Sun
Multidimensional metabolic analysis has become a new trend in establishing efficient disease monitoring systems, as the constraints associated with relying solely on a single dimension in refined monitoring are increasingly pronounced. Here, coordination polymers are employed as derivative precursors to create multishell hollow hybrids, developing an integrated metabolic monitoring system. Briefly, metabolic fingerprints are extracted from hundreds of serum samples and urine samples, encompassing not only membranous nephropathy but also related diseases, using high-throughput mass spectrometry...
March 26, 2024: Small
https://read.qxmd.com/read/38529715/ultrathin-free-standing-porous-aromatic-framework%C3%A2-membranes-for-efficient-anion-transport
#32
JOURNAL ARTICLE
Wenguang Du, Lin Liu, Liying Yin, Bo Li, Yu Ma, Xiaoyu Guo, Hong-Ying Zang, Ning Zhang, Guangshan Zhu
Porous aromatic frameworks (PAFs) show promising potential in anionic conduction due to their high stability and customizable functionality. However, the insolubility of most PAFs presents a significant challenge in their processing into membranes and subsequent applications. In this study, continuous PAF membranes with adjustable thickness were successfully created using liquid-solid interfacial polymerization. The rigid backbone and the stable C-C coupling endow PAF membrane with superior chemical and dimensional stabilities over most conventional polymer membranes...
March 26, 2024: Angewandte Chemie
https://read.qxmd.com/read/38529688/combination-of-egfr-tki-and-chemotherapy-versus-egfr-tki-monotherapy-as-neoadjuvant-treatment-of-stage-iii-n2-egfr-mutant-non-small-cell-lung-cancer
#33
JOURNAL ARTICLE
Yingqi Xu, Hao Ji, Yidan Zhang, Liwen Xiong, Baohui Han, Hua Zhong, Jianlin Xu, Runbo Zhong
BACKGROUND: The efficacy of neoadjuvant treatment with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) monotherapy in patients with stage III-N2 EGFR-mutant remains unsatisfactory. This study explored the potential benefits of combining first-generation EGFR-TKI with chemotherapy as a neoadjuvant treatment for patients with stage III-N2 EGFR-mutant non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: The medical records of patients with III-N2 EGFR-mutant NSCLC who received neoadjuvant therapy with EGFR-TKI at Shanghai Chest Hospital from October 2011 to October 2022 were retrospectively reviewed...
March 25, 2024: Oncologist
https://read.qxmd.com/read/38529603/carbon-based-nanomaterials-in-photothermal-therapy-guided-by-photoacoustic-imaging-state-of-knowledge-and-recent-advances
#34
JOURNAL ARTICLE
Yan Xing, Rui Jing, Jun Kang, Yuwen Li, Hui Zhang, Xiaoying Tang, Zhenqi Jiang
Carbon-based nanomaterials (CBNM)have been widely used in various fields due to their excellent physicochemical properties. In particular, in the area of tumor diagnosis and treatment, researchers have frequently reported them for their potential fluorescence, photoacoustic (PA), and ultrasound imaging performance, as well as their photothermal, photodynamic, sonodynamic, and other therapeutic properties. As the functions of CBNM are increasingly developed, their excellent imaging properties and superior tumor treatment effects make them extremely promising theranostic agents...
March 25, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38529473/spectrum-and-antibiotic-sensitivity-of-bacterial-keratitis-a-retrospective-analysis-of-eight-years-in-a-tertiary-referral-hospital-in-southwest-china
#35
JOURNAL ARTICLE
Rui-Qin Guo, Ji Yang, Ya-Bin Yang, Ya-Nan Chen, Yu-Yuan Xiao, Ping Xiang, Meng-Jie Dong, Min-Fang He, Yin-Ting Wang, Yun-Ling Xiao, Hong-Qin Ke, Hai Liu
PURPOSE: The objective of this study was to investigate the epidemiological characteristics, distribution of isolates, prevailing patterns, and antibiotic susceptibility of bacterial keratitis (BK) in a Tertiary Referral Hospital located in Southwest China. METHODS: A retrospective analysis was conducted on 660 cases of bacterial keratitis occurring between January 2015 and December 2022. The demographic data, predisposing factors, microbial findings, and antibiotic sensitivity profiles were examined...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38529444/percutaneous-continuous-radiofrequency-versus-pulsed-radiofrequency-thermorhizotomy-for-the-treatment-of-neuralgia-of-the-trigeminal-nerve-a-retrospective-observational-study
#36
JOURNAL ARTICLE
Juan Acevedo-Gonzalez, Juan Jose Perez-Ocampo, Maria Alejandra Bautista-Piñeros, Sofia de Los Angeles Acosta-Rivas
OBJECTIVES: Trigeminal neuralgia (TN) represents one of the most powerful manifestations of neuropathic pain. The diagnostic criteria, as well as its therapeutic modalities, stand firmly established. The percutaneous radiofrequency thermorhizotomy of the gasserian ganglion and posterior root of the trigeminal nerve stands as a widely employed procedure in this context. In this retrospective observational investigation, we undertake a comparative analysis of patients subjected to treatment employing continuous radiofrequency (C-rF) versus pulsed radiofrequency (P-rF)...
February 2024: Curēus
https://read.qxmd.com/read/38529417/investigating-the-potential-of-acacia-nilotica-enriched-glass-ionomer-cement-an-analysis-of-antimicrobial-activity-and-compressive-strength
#37
JOURNAL ARTICLE
Jessy Paulraj, Jeyashree T, Yuvashree C S, Rajeshkumar Shanmugam, Subhabrata Maiti
Background According to existing literature, introducing natural antibacterial agents into glass ionomer cement (GIC) has been associated with potential negative impacts on their strength properties. Hence, this study aims to explore the antibacterial effectiveness of glass ionomer cement enriched with Acacia nilotica and subsequently assess its compressive strength characteristics. Aim The objective of the study is to assess the antimicrobial effectiveness and compressive strength of glass ionomer cement modified with Acacia nilotica ...
February 2024: Curēus
https://read.qxmd.com/read/38529405/superior-migration-ability-of-umbilical-cord-derived-mesenchymal-stromal-cells-mscs-toward-activated-lymphocytes-in-comparison-with-those-of-bone-marrow-and-adipose-derived-mscs
#38
JOURNAL ARTICLE
Akiko Hori, Atsuko Takahashi, Yuta Miharu, Satoru Yamaguchi, Masatoshi Sugita, Takeo Mukai, Fumitaka Nagamura, Tokiko Nagamura-Inoue
Introduction: Mesenchymal stromal cells (MSCs) are activated upon inflammation and/or tissue damage and migrate to suppress inflammation and repair tissues. Migration is the first important step for MSCs to become functional; however, the migration potency of umbilical cord-derived MSCs (UC-MSCs) remains poorly understood. Thus, we aimed to assess the migration potency of UC-MSCs in comparison with those of bone marrow-derived MSCs (BM-MSCs) and adipose tissue-derived MSCs (AD-MSCs) and investigate the influence of chemotactic factors on the migration of these cells...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38529403/superior-performance-of-biocomposite-nanoparticles-plga-res-in-protecting-oocytes-against-vitrification-stimuli
#39
JOURNAL ARTICLE
Guiping Hai, Jiachen Bai, Yucheng Liu, Jun Li, Aiju Liu, Jingjing Wang, Qian Liu, Weijun Liu, Pengcheng Wan, Xiangwei Fu
Irreversible cryogenic damage caused by oocyte vitrification limits its widespread use in female fertility preservation. In recent years, nanoparticles (NPs) have gained great attention as potential alternatives in protecting oocytes against cryoinjuries. In this paper, a novel composite nanoparticle, poly (lactic-co-glycolic acid)-resveratrol (PLGA-RES) was designed to improve the biocompatibility and sustained release properties by encapsulating natural antioxidant RES into PLGA NPs. Firstly, biotoxicity and oxidation resistance of PLGA-RES were determined, and the results showed that PLGA-RES had nontoxic effect on oocyte survival during in vitro maturation (IVM) (97...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38529367/democratizing-pathological-image-segmentation-with-lay-annotators-via-molecular-empowered-learning
#40
JOURNAL ARTICLE
Ruining Deng, Yanwei Li, Peize Li, Jiacheng Wang, Lucas W Remedios, Saydolimkhon Agzamkhodjaev, Zuhayr Asad, Quan Liu, Can Cui, Yaohong Wang, Yihan Wang, Yucheng Tang, Haichun Yang, Yuankai Huo
Multi-class cell segmentation in high-resolution Giga-pixel whole slide images (WSI) is critical for various clinical applications. Training such an AI model typically requires labor-intensive pixel-wise manual annotation from experienced domain experts (e.g., pathologists). Moreover, such annotation is error-prone when differentiating fine-grained cell types (e.g., podocyte and mesangial cells) via the naked human eye. In this study, we assess the feasibility of democratizing pathological AI deployment by only using lay annotators (annotators without medical domain knowledge)...
October 2023: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
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