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https://www.readbyqxmd.com/read/27923206/delayed-intestinal-stenosis-of-nonocclusive-mesenteric-ischemia-after-autologous-blood-collection-a-case-report
#1
Takahiro Arima, Takashi Omura, Koji Hattori, Ken Kawamoto, Yuji Koba
INTRODUCTION: Nonocclusive mesenteric ischemia (NOMI) has been reported to be associated with high mortality. Early diagnosis of NOMI and prompt restoration of the intestinal blood flow is necessary in order to achieve a favorable outcome. PRESENTATION OF CASE: We present the case of a patient who developed NOMI after autologous blood collection and was treated by selective infusion of the superior mesenteric artery with papaverine, intestinal decompression using a long intestinal tube, the administration of antibiotics, and fluid replacement...
October 18, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27923201/synthesis-and-biological-evaluation-of-a-new-class-of-benzothiazines-as-neuroprotective-agents
#2
Alessandra Mancini, Alessia Chelini, Angela Di Capua, Loretta Castelli, Simone Brogi, Marco Paolino, Germano Giuliani, Andrea Cappelli, Maria Frosini, Lorenzo Ricci, Erminia Leonelli, Gianluca Giorgi, Antonio Giordani, Jacopo Magistretti, Maurizio Anzini
Neurodegenerative diseases are disorders related to the degeneration of central neurons that gradually lead to various, severe alterations of cognitive and/or motor functions. Currently, for no such diseases does any pharmacological treatment exist able to arrest its progression. Riluzole (1) is a small molecule able to interfere with multiple cellular and molecular mechanisms of neurodegeneration, and is the only approved treatment of amyotrophic lateral sclerosis (ALS), the progression of which proved to significantly slow, thus increasing somewhat average survival...
November 27, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27923168/improved-exponential-convergence-result-for-generalized-neural-networks-including-interval-time-varying-delayed-signals
#3
G Rajchakit, R Saravanakumar, Choon Ki Ahn, Hamid Reza Karimi
This article examines the exponential stability analysis problem of generalized neural networks (GNNs) including interval time-varying delayed states. A new improved exponential stability criterion is presented by establishing a proper Lyapunov-Krasovskii functional (LKF) and employing new analysis theory. The improved reciprocally convex combination (RCC) and weighted integral inequality (WII) techniques are utilized to obtain new sufficient conditions to ascertain the exponential stability result of such delayed GNNs...
November 9, 2016: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/27923166/a-comparative-systematic-review-of-yasmin-drospirenone-pill-versus-standard-treatment-options-for-symptoms-of-polycystic-ovary-syndrome
#4
REVIEW
Jing Li, Jing Ren, Wenxia Sun
OBJECTIVES: To systematically review the impact of Yasmin (drospirenone pill) compares with other standard treatments for symptoms of Polycystic Ovary Syndrome (PCOS). STUDY DESIGN: The relevant studies of the randomized controlled trials in women with PCOS treated with drospirenone were retrieved and the systematic evaluation was conducted. RESULTS: Eighteen articles were included. Compared with drospirenone (DRSP) monotherapy, DRSP plus metformin was better in reducing body mass index (BMI), luteinizing hormone (LH) and low-density lipoprotein cholesterol (LDL-C)...
November 16, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27922967/cervical-spine-deformity-in-long-standing-untreated-congenital-muscular-torticollis
#5
Mohammed Ahmed Hussein, In Sik Yun, Hanna Park, Yong Oock Kim
BACKGROUND: Congenital muscular torticollis (CMT) is a benign condition. With early diagnosis and appropriate management, it can be cured completely, leaving no residual deformity. However, long-standing, untreated CMT can lead to permanent craniofacial deformities and asymmetry. METHODS: Four adult patients presented to the author with long-standing, untreated CMT. Initial clinical assessment demonstrated tightness of the sternocleidomastoid muscle on the affected side...
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27922944/oocyte-vitrification-for-elective-fertility-preservation-the-past-present-and-future
#6
Vinay Gunnala, Glenn Schattman
PURPOSE OF REVIEW: Oocyte cryopreservation is no longer experimental and one of its rapidly growing indications is elective fertility preservation. Currently there is no sufficient evidence to support its practice and therefore its place in IVF remains uncertain. RECENT FINDINGS: Vitrification has superior post-thaw survival and fertilization outcomes compared with oocytes that were frozen with the slow-freeze technique. Oocyte vitrification produces similar IVF outcomes compared with fresh oocytes and is not associated with further obstetrical or perinatal morbidity...
December 5, 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27922879/the-changes-in-pulse-pressure-variation-or-stroke-volume-variation-after-a-tidal-volume-challenge-reliably-predict-fluid-responsiveness-during-low-tidal-volume-ventilation
#7
Sheila Nainan Myatra, Natesh R Prabu, Jigeeshu Vasishtha Divatia, Xavier Monnet, Atul Prabhakar Kulkarni, Jean-Louis Teboul
OBJECTIVES: Stroke volume variation and pulse pressure variation do not reliably predict fluid responsiveness during low tidal volume ventilation. We hypothesized that with transient increase in tidal volume from 6 to 8 mL/kg predicted body weight, that is, "tidal volume challenge," the changes in pulse pressure variation and stroke volume variation will predict fluid responsiveness. DESIGN: Prospective, single-arm study. SETTING: Medical-surgical ICU in a university hospital...
December 5, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27922861/pet-mr-outperforms-pet-ct-in-suspected-occult-tumors
#8
Tetsuro Sekine, Felipe de Galiza Barbosa, Bert-Ram Sah, Cäcilia E Mader, Gaspar Delso, Irene A Burger, Paul Stolzmann, Edwin E Ter Voert, Gustav K von Schulthess, Patrick Veit-Haibach, Martin W Huellner
BACKGROUND: To compare the diagnostic accuracy of PET/MR and PET/CT in patients with suspected occult primary tumors. METHODS: This prospective study was approved by the institutional review board. Sequential PET/CT-MR was performed in 43 patients (22 male subjects; median age, 58 years; range, 20-86 years) referred for suspected occult primary tumors. Patients were assessed with PET/CT and PET/MR for the presence of a primary tumor, lymph node metastases, and distant metastases...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27922463/the-dangers-of-estimating-v%C3%AB-o2max-using-linear-nonexercise-prediction-models
#9
Alan M Nevill, Carlton B Cooke
PURPOSE: To compare the accuracy and goodness-of-fit of two competing models (linear versus allometric) when estimating V˙O2max (ml.kg.min) using non-exercise prediction models. METHODS: The two competing models were fitted to the V˙O2max (ml.kg.min) data taken from two previously published studies. Study 1 (the Allied Dunbar National Fitness Survey, ADNFS), recruited 1732 randomly selected healthy participants, aged 16 years and over, from thirty English parliamentary constituencies...
December 1, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27922340/ratio-of-means-vs-difference-of-means-as-measures-of-superiority-non-inferiority-and-average-bioequivalence
#10
Wanjie Sun, Stella Grosser, Yi Tsong
Ratio of means (ROM) and difference of means (DOM) are often used in a superiority, non-inferiority (NI), or average bioequivalence (ABE) test to evaluate whether the test mean is superior, NI, or equivalent to the reference (placebo or active control) mean. Literature provided recommendations regarding how to choose between ROM and DOM, mainly for superiority testing. In this paper, we evaluated these two measures from other perspectives and cautioned the potential impact of different scoring systems/transformation for the same outcome (which is not rarely seen in practice) on power of a ROM or DOM test for superiority, NI or ABE: 1) For superiority, with the same margin, power remains the same for a location, scale, or combined shift (no other transformations) to scoring systems for both measures; however, for NI and ABE, different shifts can change the power of the test significantly; 2) Direction of scores (larger or smaller value indicating desirable effects) does not change power for a DOM superiority, NI, or ABE test, but it does change power tremendously for a ROM NI or ABE test...
December 6, 2016: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/27922204/encapsulation-of-bimetallic-metal-nanoparticles-into-robust-zr-based-metal-organic-frameworks-evaluation-of-the-catalytic-potential-for-size-selective-hydrogenation
#11
Christoph Rösler, Stefano Dissegna, Victor Lopez Rechac, Max Kauer, Penghu Guo, Stuart Turner, Kevin Ollegott, Hirokazu Kobayashi, Tomokazu Yamamoto, Daniel Peeters, Yuemin Wang, Syo Matsumura, Gustaaf Van Tendeloo, Hiroshi Kitagawa, Martin Muhler, Francesc X Llabrés I Xamena, Roland A Fischer
The realization of metal NPs with bimetallic character and distinct composition for specific catalytic applications is an intensively studied field. Due to the synergy between metals, most of the bimetallic particles exhibit unique properties, only hardly provided by the individual monometallic counterparts. However, as small sized NPs possess high surface energy, agglomeration during catalytic reactions is favored. Sufficient stabilization can be achieved by confinement of NPs in porous support materials. In this sense, especially MOFs gained a lot of attention during the last years, however, encapsulation of bimetallic species remains challenging...
December 6, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27922124/convex-analysis-of-mixtures-for-separating-non-negative-well-grounded-sources
#12
Yitan Zhu, Niya Wang, David J Miller, Yue Wang
Blind Source Separation (BSS) is a powerful tool for analyzing composite data patterns in many areas, such as computational biology. We introduce a novel BSS method, Convex Analysis of Mixtures (CAM), for separating non-negative well-grounded sources, which learns the mixing matrix by identifying the lateral edges of the convex data scatter plot. We propose and prove a sufficient and necessary condition for identifying the mixing matrix through edge detection in the noise-free case, which enables CAM to identify the mixing matrix not only in the exact-determined and over-determined scenarios, but also in the under-determined scenario...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922099/ultra-sustainable-fe78si9b13-metallic-glass-as-a-catalyst-for-activation-of-persulfate-on-methylene-blue-degradation-under-uv-vis-light
#13
Zhe Jia, Xiaoguang Duan, Wenchang Zhang, Weimin Wang, Hongqi Sun, Shaobin Wang, Lai-Chang Zhang
Stability and reusability are important characteristics of advanced catalysts for wastewater treatment. In this work, for the first time, sulfate radicals (SO4∙(-)) with a high oxidative potential (E(o) = 2.5-3.1 V) were successfully activated from persulfate by a Fe78Si9B13 metallic glass. This alloy exhibited a superior surface stability and reusability while activating persulfate as indicated by it being used for 30 times while maintaining an acceptable methylene blue (MB) degradation rate. The produced SiO2 layer on the ribbon surface expanded strongly from the fresh use to the 20(th) use, providing stable protection of the buried Fe...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922025/water-exchange-method-significantly-improves-adenoma-detection-rate-a-multicenter-randomized-controlled-trial
#14
Hui Jia, Yanglin Pan, Xuegang Guo, Lina Zhao, Xiangping Wang, Linhui Zhang, Tao Dong, Hui Luo, Zhizheng Ge, Jun Liu, Jianyu Hao, Ping Yao, Yao Zhang, Hongyu Ren, Weizhen Zhou, Yujie Guo, Wei Zhang, Xiaolin Chen, Dayong Sun, Xiaoqiang Yang, Xiaoyu Kang, Na Liu, Zhiguo Liu, Felix Leung, Kaichun Wu, Daiming Fan
OBJECTIVES: Adenoma detection rate (ADR) is a key colonoscopy quality indicator in Western clinical literature. Our low ADR prompted us to assess novel methods to improve performance. Western retrospective reports suggested that water exchange (WE) could increase ADR. However, most of these studies used pain score or intubation rate as the primary outcome. Here we test the hypothesis that WE significantly increases ADR among Chinese colonoscopists and design a prospective randomized controlled trial using ADR as our primary outcome...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27921389/superiority-of-sds-lysis-over-saponin-lysis-for-direct-bacterial-identification-from-positive-blood-culture-bottle-by-maldi-tof-ms
#15
Yvan Caspar, Cécile Garnaud, Mariya Raykova, Sébastien Bailly, Marie Bidart, Danièle Maubon
PURPOSE: Fast species diagnosis has an important health care impact, as rapid and specific antibacterial therapy is of clear benefit for patient's outcome. Here we propose a new protocol for species identification directly from positive blood cultures. EXPERIMENTAL DESIGN: We compared four in-house protocols for bacterial identification by mass spectrometry directly from clinical positive blood cultures evaluating 2 lytic agents, SDS and saponin, and 2 protein extraction schemes, fast (FP) and long (LP)...
December 6, 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/27921386/cytotoxicity-of-a-series-of-norcantharidin-inspired-tetrahydroepoxyisoindole-carboxamides
#16
Christopher Peter Gordon, Lawson K Spare, Pasquale Falsetta, Jayne Gilbert, David G Harman, Mark A Baker, Feng Li, Adam McCluskey, Jack K Clegg, Jennette A Sakoff, Janice R Aldrich-Wright
A series of 28 norcantharidin (NorC) inspired analogues were accessed via a robust two-step Ugi intramolecular Diels-Alder (IMDA) sequence. Four analogues displayed equipotent whole cell cytotoxicity to NorC and cisplatin against a number of cancer cell lines and a normal breast cell line (MCF10A). Notably (3S,3aS,6R)-2-benzyl-7-methyl-N-(naphthalen-2-yl)-1-oxo-1,2,3,6-tetrahydro-3a,6-epoxyisoindole-3-carboxamide (trans-27) displayed superior whole cell activity against breast (MCF-7, GI50 = 2.9 µM) and colon (HT29, GI50 = 6...
December 6, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27921382/core-shell-silk-hydrogels-with-spatially-tuned-conformations-as-drug-delivery-system
#17
Le-Ping Yan, Joaquim M Oliveira, Ana L Oliveira, Rui L Reis
Hydrogels of spatially controlled physicochemical properties are appealing platforms for tissue engineering and drug delivery. In this study, core-shell silk fibroin (SF) hydrogels of spatially controlled conformation were developed. The core-shell structure in the hydrogels was formed by means of soaking the preformed (enzymatically crosslinked) random coil SF hydrogels in methanol. When increasing the methanol treatment time from 1 to 10 min, the thickness of the shell layer can be tuned from about 200 to about 850 μm as measured in wet status...
December 5, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27921299/one-dose-per-day-compared-to-multiple-doses-per-day-of-gentamicin-for-treatment-of-suspected-or-proven-sepsis-in-neonates
#18
REVIEW
Shripada C Rao, Ravisha Srinivasjois, Kwi Moon
BACKGROUND: Animal studies and trials in older children and adults suggest that a 'one dose per day' regimen of gentamicin is superior to a 'multiple doses per day' regimen. OBJECTIVES: To compare the efficacy and safety of one dose per day compared to multiple doses per day of gentamicin in suspected or proven sepsis in neonates. SEARCH METHODS: Eligible studies were identified by searching the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 3) in the Cochrane Library (searched 8 April 2016), MEDLINE (1966 to 8 April 2016), Embase (1980 to 8 April 2016), and CINAHL (December 1982 to 8 April 2016)...
December 6, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27921277/surgery-for-acute-exacerbation-of-chronic-mesenteric-ischemia-a-case-report
#19
Shinji Abe, Tomoji Yamakawa, Hideaki Kawashima, Makoto Yoshida, Setsuji Takanashi, Motoya Kashiyama, Masahiro Ishigooka, Yasushige Shingu, Yoshiro Matsui
BACKGROUND: Chronic mesenteric ischemia (CMI) is a rare disease; however, symptomatic CMI has a risk of acute exacerbation without timely revascularization. CASE PRESENTATION: A 54-year-old man who had had postprandial pain for 6 months was admitted to our hospital because of vomiting and diarrhea. Although the celiac and superior mesenteric arteries were occluded at the proximal portion, contrast enhancement of the bowel wall was good in contrast-enhanced computed tomography (CECT)...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27921207/pattern-of-venous-collateral-development-after-splenic-vein-occlusion-in-an-extended-whipple-procedure-whipple-at-the-splenic-artery-and-long-term-results
#20
Ismael Dominguez Rosado, Sanjeev Bhalla, Luis A Sanchez, Ryan C Fields, William G Hawkins, Steven M Strasberg
BACKGROUND: Extended Whipple procedures may require division of the splenic vein (SV). Controversy exists regarding the risk of sequelae of sinistral portal hypertension when the SV is ligated without reimplantation. The aim of this study was to identify postoperative venous collateral patterns and sequelae of SV ligation, as well as long-term results in an extended Whipple procedure. STUDY DESIGN: Patients who had an extended Whipple procedure (Whipple at the Splenic Artery or WATSA) were entered in an institutional database...
December 5, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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