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Attachment oxytocine pregnanc

Monali Wakle-Prabagaran, Ramón A Lorca, Xiaofeng Ma, Susan J Stamnes, Chinwendu Amazu, Jordy J Hsiao, Celeste M Karch, Krzysztof L Hyrc, Michael E Wright, Sarah K England
The large-conductance, voltage-gated, calcium (Ca(2+))-activated potassium channel (BKCa) plays an important role in regulating Ca(2+)signaling and is implicated in the maintenance of uterine quiescence during pregnancy. We used immunopurification and mass spectrometry to identify proteins that interact with BKCain myometrium samples from term pregnant (≥37 wk gestation) women. From this screen, we identified alpha-2-macroglobulin (α2M). We then used immunoprecipitation followed by immunoblot and the proximity ligation assay to confirm the interaction between BKCaand both α2M and its receptor, low-density lipoprotein receptor-related protein 1 (LRP1), in cultured primary human myometrial smooth muscle cells (hMSMCs)...
April 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
Claudia Klein
Few, if any, biological processes are as diverse among domestic species as establishment of early pregnancy, in particular maternal recognition of pregnancy. Following fertilization and initial development in the mare oviduct, selective transport of the embryo through the uterotubal junction driven by embryo-derived PGE2 occurs. Upon arrival in the uterus, an acellular glycoprotein capsule is formed that covers the embryo, blastocyst, and conceptus (embryo and associated extraembryonic membranes) between the second and third weeks of pregnancy...
2015: Advances in Anatomy, Embryology, and Cell Biology
Lizhu Luo, Xiaole Ma, Xiaoxiao Zheng, Weihua Zhao, Lei Xu, Benjamin Becker, Keith M Kendrick
We find infant faces highly attractive as a result of specific features which Konrad Lorenz termed "Kindchenschema" or "baby schema," and this is considered to be an important adaptive trait for promoting protective and caregiving behaviors in adults, thereby increasing the chances of infant survival. This review first examines the behavioral support for this effect and physical and behavioral factors which can influence it. It then provides details of the increasing number of neuroimaging and electrophysiological studies investigating the neural circuitry underlying this baby schema effect in parents and non-parents of both sexes...
2015: Frontiers in Psychology
Rebecca Gregory, Hu Cheng, Heather A Rupp, Dale R Sengelaub, Julia R Heiman
After giving birth, women typically experience decreased sexual desire and increased responsiveness to infant stimuli. These postpartum changes may be viewed as a trade-off in reproductive interests, which could be due to alterations in brain activity including areas associated with reward. The goal of this study was to describe the roles of oxytocin and parity on reward area activation in response to reproductive stimuli, specifically infant and sexual images. Because they have been shown to be associated with reward, the ventral tegmental area (VTA) and nucleus accumbens (NAc) were targeted as areas of expected alterations in activity...
March 2015: Hormones and Behavior
David Tipene-Leach, Sally Baddock, Sheila Williams, Raymond Jones, Angeline Tangiora, Sally Abel, Barry Taylor
BACKGROUND: Sudden Unexpected Death in Infancy (SUDI) has persistent high rates in deprived indigenous communities and much of this mortality is attributable to unsafe sleep environments. Whilst health promotion worldwide has concentrated on avoidance of bedsharing, the indigenous Māori community in New Zealand has reproduced a traditional flax bassinet (wahakura) designed to be used in ways that include bedsharing. To date there has been no assessment of the safety of this traditional sleeping device...
2014: BMC Pediatrics
Valsamma Eapen, Mark Dadds, Bryanne Barnett, Jane Kohlhoff, Feroza Khan, Naomi Radom, Derrick M Silove
In this paper, we aimed to assess cross-sectionally and longitudinally associations between disturbances in maternal early attachment experiences, symptoms of separation anxiety and depression and oxytocin plasma levels. We examined a mediational model that tested the hypothesis that anxious attachment style arising from the mothers' early bonding experiences with her own parents was associated with high levels of separation anxiety which, via its impact on depression, was associated with reduced levels of oxytocin in the postnatal period...
2014: PloS One
Sven Budik, Franziska Palm, Ingrid Walter, Magdalena Helmreich, Christine Aurich
Oxytocin (OT) and arginine vasopressin (AVP) have been detected in the yolk sac of the pre-attachment equine conceptus. Therefore, we have assessed the presence of OT and AVP receptors in equine conceptuses between Days 10 and 16 of pregnancy by qualitative PCR, quantitative PCR and immunohistochemistry. Expression of OT receptor and of the AVP receptors V1aR and V2R could be verified after sequencing the RT-PCR products of the expected length. The size of conceptuses used for quantitative PCR significantly increased with day of pregnancy (P<0...
2012: Reproduction, Fertility, and Development
Amanda P Borrow, Nicole M Cameron
The hormone oxytocin (OT) is released both centrally and peripherally during and after mating. Although research in humans suggests a central role in sexuality, the most reliable findings to date involve peripheral activation. This review will discuss these results and will particularly focus on understanding the most recent findings from fMRI data and the effects of exogenous peripheral OT administration. We will then consider hypotheses of the roles played by central and systemic OT release as well as their control and modulation in the female, summarizing recent findings from animal research...
March 2012: Hormones and Behavior
Megan Galbally, Andrew James Lewis, Marinus van Ijzendoorn, Michael Permezel
BACKGROUND: Oxytocin is associated with the establishment and quality of maternal behavior in animal models. Parallel investigations in humans are now under way. This article reviews the current research examining the role of oxytocin in mother-infant relations, attachment, and bonding in humans. METHODS: A systematic search was made of three electronic databases and other bibliographic sources for published research studies that examined oxytocin and mother-infant relations in humans, including attachment, maternal behavior, parenting, and mother-infant relations...
January 2011: Harvard Review of Psychiatry
Wendy Saltzman, Dario Maestripieri
In nonhuman primates and humans, similar to other mammals, hormones are not strictly necessary for the expression of maternal behavior, but nevertheless influence variation in maternal responsiveness and parental behavior both within and between individuals. A growing number of correlational and experimental studies have indicated that high circulating estrogen concentrations during pregnancy increase maternal motivation and responsiveness to infant stimuli, while effects of prepartum or postpartum estrogens and progestogens on maternal behavior are less clear...
July 1, 2011: Progress in Neuro-psychopharmacology & Biological Psychiatry
Lane Strathearn, Linda C Mayes
Maternal cocaine addiction is a significant public health issue particularly affecting children, with high rates of reported abuse, neglect, and foster care placement. This review examines both preclinical and clinical evidence for how cocaine abuse may affect maternal care and infant development, exploring brain, behavioral, and neuroendocrine mechanisms. There is evidence that cocaine affects infant development both directly, via in utero exposure, and indirectly via alterations in maternal care. Two neural systems known to play an important role in both maternal care and cocaine addiction are the oxytocin and dopamine systems, mediating social and reward-related behaviors and stress reactivity...
February 2010: Annals of the New York Academy of Sciences
José Manuel Giménez Amaya
Functional neuroimage techniques show how certain brain areas are activated, while others become silent, when a mother sees her child or hears his/her voice. This is the neural correlate of the emotion, which the presence of her child generates, under diverse circumstances, in the mother. Brain is organised to mediate the complex maternal behaviour. For that, gene expression is orchestrated by different hormonal and neurochemicals factors of pregnancy. Maternal behaviors might be reasonably well characterized in terms of cognitive-emotional interactions and brain amygdala function is their cognitive-emotional connector hub...
September 2009: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
Paula J Laws, Carylyn Lim, Sally Tracy, Elizabeth A Sullivan
BACKGROUND: Around 2% of women who give birth in Australia each year give birth in a birth centre. There is currently no standard definition of a birth centre in Australia. AIMS: This study aimed to locate all birth centres nationally, describe their characteristics and procedures, and develop a definition. METHODS: Surveys were sent to 23 birth centres. Questions included: types of procedures, equipment and pain relief available, staffing, funding, philosophies, physical characteristics and transfer procedures...
June 2009: Australian & New Zealand Journal of Obstetrics & Gynaecology
Hein O Sigling, Inge G Wolterink-Donselaar, Berry M Spruijt
We are interested in the rat as an animal model for infant-mother attachment. In the first experiment we tried to distinguish between a preference for familiar animals (attachment theory) and a preference for genetically related animals (kin selection theory) with the use of an early cross-fostering procedure. Genetic relationships did not influence preferences in cross-fostered pups on postnatal day 17, only familiarity did. Subsequently we investigated if peptides known to influence affiliative behaviors were also effective in the present paradigm...
June 10, 2009: European Journal of Pharmacology
E Sibolboro Mezzacappa, J Endicott
Maternal depression is the most common complication of the postpartum, having devastating and long lasting effects on mother and infant. Lactation is associated with attenuated stress responses, especially that of cortisol, and the lactogenic hormones, oxytocin and prolactin, are associated with anti-depressant and anxiolytic effects. These associations suggest that breast-feeding may decrease maternal depressive symptoms, yet empirical results have been conflicting. Recent findings have indicated that parity may mediate the association between breast-feeding and stress response...
2007: Archives of Women's Mental Health
Ruth Feldman, Aron Weller, Orna Zagoory-Sharon, Ari Levine
Although research on the neurobiological foundation of social affiliation has implicated the neuropeptide oxytocin in processes of maternal bonding in mammals, there is little evidence to support such links in humans. Plasma oxytocin and cortisol of 62 pregnant women were sampled during the first trimester, last trimester, and first postpartum month. Oxytocin was assayed using enzyme immunoassay, and free cortisol was calculated. After the infants were born, their interactions with their mothers were observed, and the mothers were interviewed regarding their infant-related thoughts and behaviors...
November 2007: Psychological Science
Torsten M Reinheimer
BACKGROUND: Preterm labour (PTL) is a major cause of neonatal mortality and morbidity, and oxytocin (OT) antagonists are potential tocolytics. Atosiban (TRACTOCILE) is a mixed vasopressin V1A/OT antagonist registered for acute treatment of PTL in Europe. Other off-label drugs have serious side effects. Barusiban is a selective OT antagonist which has reached clinical development. A monkey model with OT-induced PTL was developed to compare barusiban and atosiban. In addition, the feasibility for long-term treatment of PTL with barusiban was explored...
2007: BMC Pregnancy and Childbirth
Ari Levine, Orna Zagoory-Sharon, Ruth Feldman, Aron Weller
Oxytocin (OT), a nanopeptide hormone, plays a role in the emergence of maternal behavior, yet few studies examined OT in humans across pregnancy and the postpartum. We followed healthy women at three points: first trimester of pregnancy, third trimester, and first postpartum month. Plasma OT levels showed high individual stability. A third of the sample showed consistent OT levels, whereas others showed increasing or decreasing trends or peak in late pregnancy. The increase in OT from early to late pregnancy correlated with higher maternal-fetal bonding...
June 2007: Peptides
Ruth Feldman
Synchrony, a construct used across multiple fields to denote the temporal relationship between events, is applied to the study of parent-infant interactions and suggested as a model for intersubjectivity. Three types of timed relationships between the parent and child's affective behavior are assessed: concurrent, sequential, and organized in an ongoing patterned format, and the development of each is charted across the first year. Viewed as a formative experience for the maturation of the social brain, synchrony impacts the development of self-regulation, symbol use, and empathy across childhood and adolescence...
March 2007: Journal of Child Psychology and Psychiatry, and Allied Disciplines
W Jonas, I Wiklund, E Nissen, A-B Ransjö-Arvidson, K Uvnäs-Moberg
AIM: To investigate (1) the skin temperature pattern in newborns two days after birth in connection to breastfeeding and to examine (2) if the administration of epidural analgesia (EDA) and oxytocin (OT) infusion during labour influences this parameter at this point of time. METHOD: Forty-seven mother-infant pairs were included in the study: nine mothers had received OT stimulation during labour (OT group), 20 mothers had received an EDA and OT during labour (EDA group), while 18 mothers had received neither EDA nor OT stimulation during labour (control group)...
January 2007: Early Human Development
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