keyword
MENU ▼
Read by QxMD icon Read
search

Oxytocine attachement

keyword
https://www.readbyqxmd.com/read/29443077/contractility-measurements-of-human-uterine-smooth-muscle-to-aid-drug-development
#1
Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W Gruber
Discovery and characterization of novel pharmaceutical compounds or biochemical probes rely on robust and physiologically relevant assay systems. We describe methods to measure ex vivo myometrium contractility. This assay can be used to investigate factors and molecules involved in the modulation of myometrial contraction and to determine their excitatory or inhibitory actions, and hence their therapeutic potential in vivo. Biopsies are obtained from women undergoing cesarean section delivery with informed consent...
January 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29436774/oxytocin-structure-and-function-in-new-world-monkeys-from-pharmacology-to-behavior
#2
Aaryn Mustoe, Jack H Taylor, Jeffrey A French
Oxytocin (OT) is a hypothalamic nonapeptide that mediates a host of physiological and behavioral processes including reproductive physiology and social attachments. While the OT sequence structure is highly conserved among mammals, New World monkeys (NWMs) represent an unusual 'hot spot' in OT structure variability among mammals. At least six distinct OT ligand variants among NWMs exist, yet it is currently unclear whether these evolved structural changes result in meaningful functional consequences. NWMs offer a new area to explore how these modifications to OT and its canonical G-protein coupled OT receptor (OTR) may mediate specific cellular, physiological, and behavioral outcomes...
February 13, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29412506/no-evidence-of-association-of-oxytocin-polymorphisms-with-breastfeeding-in-two-independent-samples
#3
Lucía Colodro-Conde, Juan F Sanchez-Romera, Penelope A Lind, Gu Zhu, Nicholas G Martin, Sarah E Medland, Juan R Ordoñana
Oxytocin has an important function in breastfeeding via its role in the milk ejection reflex and in attachment and bonding processes. Genetic factors account for a significant part of the individual differences in breastfeeding behaviour. OXT and OXTR have been proposed as gene candidates for breastfeeding. Previous studies have focused on certain single nucleotide polymorphisms (SNPs) within these genes, finding null or inconsistent results. The present study analyses the associations between a wide coverage of polymorphisms in OXT and OXTR and breastfeeding duration from two large and independent unselected samples comprising a total of 580 and 2,112 female twin mothers from the Murcia Twin Registry (MTR; Spain) and QIMR (Australia), respectively...
February 7, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29410310/associations-between-oxytocin-receptor-gene-oxtr-methylation-plasma-oxytocin-and-attachment-across-adulthood
#4
Natalie C Ebner, Tian Lin, Melis Muradoglu, Devon H Weir, Gabriela M Plasencia, Travis S Lillard, Hossein Pournajafi-Nazarloo, Ronald A Cohen, C Sue Carter, Jessica J Connelly
The neuropeptide oxytocin (OT) has been implicated in a wide range of affiliative processes. OT exerts its functions via OT receptors, which are encoded by the oxytocin receptor gene (OXTR). Epigenetic modification of OXTR through the process of DNA methylation has been associated with individual differences in behavioral phenotypes. Specifically, lower levels of OXTR methylation have been linked to better social and affective functioning. However, research on epigenetic mechanisms of OXTR is scarce in non-clinical populations, and even less is known about epigenetic variability across adulthood...
February 2, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29353531/oxytocin-receptor-gene-variation-behavioural-inhibition-and-adult-separation-anxiety-role-in-complicated-grief
#5
Miriam A Schiele, Barbara Costa, Marianna Abelli, Claudia Martini, David S Baldwin, Katharina Domschke, Stefano Pini
OBJECTIVES: Complicated grief (CG) following bereavement significantly increases the risk for mood and anxiety disorders. The severity of grief reactions may be interactively influenced by temperamental and psychological factors such as behavioural inhibition (BI) and separation anxiety (SA) as well as biological factors. Given its central role in attachment and stress processing, a genetic variant in the oxytocin receptor (OXTR) gene was thus investigated in order to elucidate the direction of association as well as its interaction with BI and SA in the moderation of CG severity...
January 22, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29302631/oxytocin-monolayer-based-impedimetric-biosensor-for-zinc-and-copper-ions
#6
Kiran Kumar Tadi, Israel Alshanski, Evgeniy Mervinetsky, Gerard Marx, Panayiota Petrou, Karussis M Dimitrios, Chaim Gilon, Mattan Hurevich, Shlomo Yitzchaik
Zinc and copper are essential metal ions for numerous biological processes. Their levels are tightly maintained in all body organs. Impairment of the Zn2+ to Cu2+ ratio in serum was found to correlate with many disease states, including immunological and inflammatory disorders. Oxytocin (OT) is a neuropeptide, and its activity is modulated by zinc and copper ion binding. Harnessing the intrinsic properties of OT is one of the attractive ways to develop valuable metal ion sensors. Here, we report for the first time an OT-based metal ion sensor prepared by immobilizing the neuropeptide onto a glassy carbon electrode...
December 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/29244625/the-role-of-oxytocin-and-vasopressin-in-attachment
#7
C Sue Carter
Selective relationships and attachments are central to human health and well-being, both in current societies and during the course of evolution. The presence or absence of social bonds has consequences across the lifespan. The neurobiology of attachment is grounded in neuroendocrine substrates that are shared with reproduction and survival. Experimental studies of species, such as sheep or prairie voles, capable of showing selective social behaviors toward offspring or partners, have provided empirical evidence for the role of oxytocin and vasopressin in the formation of selective attachments...
2017: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/29244620/calming-cycle-theory-and-the-co-regulation-of-oxytocin
#8
Martha G Welch, Robert J Ludwig
The biological functions of oxytocin in attachment and bonding between mother and infant in parturition and breastfeeding and between adults have been studied extensively. However, most current authors have proposed that infant attachment to the mother is learned through operant conditioning mechanisms via the infant's brain and central nervous system. We propose that oxytocin levels in the mother and infant are co-regulated by emotional connection or disconnection, and that the autonomic co-conditioning learning mechanism can be exploited to change a negative physiological and behavioral response between mother and infant into a positive one...
2017: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/29236527/paradoxical-effects-of-intranasal-oxytocin-on-trust-in-inpatient-and-community-adolescents
#9
Amanda Venta, Carolyn Ha, Salome Vanwoerden, Elizabeth Newlin, Lane Strathearn, Carla Sharp
Research suggests that oxytocin, a neuropeptide implicated in attachment, is a promising clinical tool because it increases affiliation and attachment behaviors, which are reduced in a range of psychiatric disorders. Oxytocin has been recommended as a psychiatric treatment for adolescents, but this remains largely unstudied. Skepticism is warranted, based on mixed findings in adults and absence of data across development. The objective of this study was to examine the effect of intranasal oxytocin on attachment-related and non-attachment-related trust in an interactive game, determining how this effect differs among inpatient adolescents and healthy controls and whether this effect is moderated by attachment security...
December 13, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29204125/alcohol-s-effects-on-pair-bond-maintenance-in-male-prairie-voles
#10
Andre T Walcott, Andrey E Ryabinin
Alcohol abuse can have devastating effects on social relationships. In particular, discrepant patterns of heavy alcohol consumption are associated with increased rates of separation and divorce. Previous studies have attempted to model these effects of alcohol using socially monogamous prairie voles. These studies showed that alcohol consumption can inhibit the formation of pair bonds in this species. While these findings indicated that alcohol's effects on social attachments can involve biological mechanisms, the formation of pair bonds does not properly model long-term human attachments...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29157488/l%C3%A2-hypophyse-et-ses-traitements-comment-peuvent-ils-influer-sur-le-comportement-the-pituitary-and-its-treatments-how-can-they-influence-behaviour
#11
C Mouly, F Borson-Chazot, P Caron
Behaviour may be influenced by pituitary hormones or treatments. Dopamine agonist (DA) indicated in prolactinomas treatment can cause side effects, and especially impulse control disorders. In the context of prolactinomas treatment, impulse control disorders (ICD) have been reported like gambling, compulsive shopping, but mostly hypersexuality. These ICD can occur with low AD doses, and seem to be independent of type of molecule and psychiatric medical history. The main pathophysiologic hypothesis is a dysregulation of dopaminergic pathway involved in reward system...
October 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29104011/oxytocin-inhibits-ox-ldl-induced-adhesion-of-monocytic-thp-1-cells-to-human-brain-microvascular-endothelial-cells
#12
Shuyan Liu, Shengying Pan, Jing Tan, Weina Zhao, Fengguo Liu
The attachment of monocytes to human brain microvascular endothelial cells (HBMVEs) caused by oxidized low-density lipoprotein (ox-LDL) is associated with an early event and the pathological progression of cerebrovascular diseases. Oxytocin (OT) is a human peptide hormone that is traditionally used as a medication to facilitate childbirth. However, little information is available regarding the physiological function of OT in brain endothelial dysfunction. In the present study, our results indicate that the oxytocin receptor (OTR) was expressed in human brain microvascular endothelial cells (HBMVEs) and was upregulated in response to ox-LDL in a concentration-dependent manner...
December 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29072476/oxytocin-modulates-charismatic-influence-in-groups
#13
Ilanit Gordon, Yair Berson
Charismatic leaders have had tremendous effects on the fortunes and fates of individuals and societies across the world. Via verbal and nonverbal signaling, such leaders form profound emotional bonds with followers. Despite evidence for its powerful effects, we know very little about what facilitates the charismatic relationship. Here, we argue that the neuropeptide oxytocin (OT), known to be implicated in parent-child attachment, also enhances the effects of charismatic leaders in groups. In a double-blind placebo-controlled study, we administered intranasal OT to participants, led by a confederate trained to exhibit charisma, and monitored participants' responses to the confederate's signaling while leading a group task...
October 26, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/29059645/-prevention-postpartum-hemorrhage
#14
Валерий Г Волков, Елена М Гусева
INTRODUCTION: Postpartum hemorrhage remains a leading cause of maternal morbidity and mortality. THE AIM: To evaluate the effectiveness of oxytocin into the umbilical vein for the prevention of postpartum hemorrhage. MATERIALS AND METHODS: A total of 105 women were included. Formed two groups. In group, I (n = 51) - as prevention of bleeding was administered oxytocin in the umbilical cord vein. In group, II (n = 54) 10 IU oxytocin was carried out by intramuscular injection in the thigh during the first minute after birth...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29044580/low-oxytocin-levels-are-related-to-alexithymia-in-anorexia-nervosa
#15
Cindy Schmelkin, Franziska Plessow, Jennifer J Thomas, Emily K Gray, Dean A Marengi, Reitumetse Pulumo, Lisseth Silva, Karen K Miller, Nouchine Hadjikhani, Debra L Franko, Kamryn T Eddy, Elizabeth A Lawson
OBJECTIVE: Anorexia nervosa is associated with social-emotional functioning deficits and low levels of the social neurohormone oxytocin, even after weight gain. The relationship between low oxytocin levels and social-emotional functioning impairment has not been studied. METHOD: We performed a cross-sectional study of 79 women (19 who were less than 85% of ideal body weight [IBW] with anorexia nervosa [AN], 26 who were 90-120% IBW with a history of AN [AN-WR], and 34 who were 90-120% IBW with no eating disorder history [H])...
October 16, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29033879/nasally-administered-oxytocin-has-limited-effects-on-owner-directed-attachment-behavior-in-pet-dogs-canis-lupus-familiaris
#16
Lauren E Thielke, Giovanna Rosenlicht, Sarina R Saturn, Monique A R Udell
The present study explored the effects of intranasal oxytocin, a naturally occurring hormone, on the behavior of pet dogs during an attachment test. Each dog participated in two testing sessions. On one visit saline was administered nasally, and on another, oxytocin was administered nasally. For half of the dogs (n = 20), solutions were administered with a Mucosal Atomization Device (MAD) and for half of the dogs (n = 20), solutions were administered using a nasal spray bottle. Condition order was counterbalanced and a double-blind methodology was employed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28983270/intranasal-oxytocin-treatment-increases-eye-gaze-behavior-toward-the-owner-in-ancient-japanese-dog-breeds
#17
Miho Nagasawa, Misato Ogawa, Kazutaka Mogi, Takefumi Kikusui
Dogs acquired unique cognitive abilities during domestication, which is thought to have contributed to the formation of the human-dog bond. In European breeds, but not in wolves, a dog's gazing behavior plays an important role in affiliative interactions with humans and stimulates oxytocin secretion in both humans and dogs, which suggests that this interspecies oxytocin and gaze-mediated bonding was also acquired during domestication. In this study, we investigated whether Japanese breeds, which are classified as ancient breeds and are relatively close to wolves genetically, establish a bond with their owners through gazing behavior...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28949306/adult-attachment-style-and-suicidality
#18
Mario Miniati, Antonio Callari, Stefano Pini
BACKGROUND: There is evidence in the literature that adverse early attachment experiences and subsequent attachment insecurities during adulthood would lead to pessimism, low self-esteem, hopelessness and, ultimately, to suicide risk. SUBJECTS AND METHODS: This paper aims to review finding on the link between attachment style and suicidality. We searched the literature using the database of the U.S. National Center for Biotechnology Information (NCBI)-MedLine/Pubmed system from January 1992 until December 2016...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28929993/reduced-claw-vacuum-and-b-phase-during-low-milk-flow-does-not-impact-oxytocin-release-and-milking-performance
#19
Anna-Lena Neuheuser, Ann-Catherine Schwinn, Olga Wellnitz, Lorenzo E Hernández-Castellano, Rupert M Bruckmaier
Oxytocin release, milking characteristics, and teat condition were investigated with reduced claw vacuum and pulsation settings compared to milking at regular settings with or without pre-stimulation. The reduced vacuum and pulsation settings during low milk flow are expected to protect the teat tissue before the occurrence of milk ejection at the start of milking, and at the end of milking during a potential overmilking period, i.e. at a milk flow <200 g/min. Seven cows were machine-milked either after a 60 s manual pre-stimulation, or without pre-stimulation and reduced vacuum and pulsation settings, or at full vacuum and normal pulsation during the start of milking...
September 20, 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28822550/technical-note-reduced-pulsation-chamber-vacuum-at-normal-pulsation-rate-and-ratio-provides-adequate-prestimulation-to-induce-oxytocin-release-and-milk-ejection-while-simultaneous-milk-flow-is-prevented
#20
Anna-Lena Neuheuser, Claire Belo, Rupert M Bruckmaier
In the present study we investigated the milking characteristics and the oxytocin release in dairy cows milked after either manual prestimulation or a premilking period with pulsating liners at normal pulsation rate (60) and ratio (60:40) while the pulsation chamber vacuum (PCV) was reduced to 20 kPa to prevent the opening of the liners. During the milking trial with 8 cows the PCV reduction was started either before attachment (PCV-1) or immediately after attachment (PCV-2) of the teat cups. Milk yields, total milking times, average milk flows, peak flow rates, the duration of milk flow plateaus, and the duration of milk flow declines did not differ among the 3 treatments...
August 16, 2017: Journal of Dairy Science
keyword
keyword
98775
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"