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Zhang Feng

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https://www.readbyqxmd.com/read/28938658/comparison-of-direct-sequencing-and-amplification-refractory-mutation-system-for-detecting-epidermal-growth-factor-receptor-mutation-in-non-small-cell-lung-cancer-patients-a-systematic-review-and-meta-analysis
#1
Qi Feng, Zu-Yao Yang, Jia-Tong Zhang, Jin-Ling Tang
BACKGROUND: Direct sequencing and amplification refractory mutation system (ARMS) are commonly used to detect epidermal growth factor receptor (EGFR) mutation status in patients with non-small-cell lung cancer to inform the decision-making on tyrosine kinase inhibitors treatment. This study aimed to systematically compare the two methods in terms of the rate of detected mutations and the association of detected mutations with clinical outcomes. MATERIAL AND METHODS: PubMed, EMBASE, China National Knowledge Infrastructure (in Chinese) and Wanfang database (in Chinese) were searched to identify relevant studies...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938644/intravascular-ultrasound-guidance-in-drug-eluting-stents-implantation-a-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials
#2
Cheng Qian, Hong Feng, Jianlei Cao, Guangyu Zhang, Yanggan Wang
OBJECTIVE: Previous evidence suggested that intravascular ultrasound (IVUS) guidance could improve outcomes after drug-eluting stents (DES) placement, largely driven by data from observational studies. We, therefore, performed a meta-analysis and trial sequential analysis of randomized controlled trials to overcome this limitation. RESULTS: The retrieval process yielded 7 RCTs with 3,192 patients. Compared to the angiography guidance, IVUS-guided DES implantation was associated with a significant reduction in the major adverse cardiac events (MACE) (OR 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938639/spondin2-is-a-new-prognostic-biomarker-for-lung-adenocarcinoma
#3
Xiaopeng Yuan, Tingting Bian, Jian Liu, Honggang Ke, Jia Feng, Qing Zhang, Li Qian, Xiaoli Li, Yifei Liu, Jianguo Zhang
Spondin 2 (SPON2) is a member of the F-spondin superfamily of genes that encode an extracellular matrix protein. SPON2 has been identified by mRNA differential display screening of cancerous and noncancerous lung cell lines in vitro [1], however, its role in pulmonary adenocarcinoma (ADC) patients remains unclear. In our study, we evaluated whether SPON2 can be used as a biomarker for the diagnosis of pulmonary ADC and any association between SPON2 protein levels and clinicopathological characteristics. Firstly, the mRNA levels of SPON2 in pulmonary ADCs and normal adjacent tissue samples were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) (n = 60) assay and the expression of SPON2 protein were detected by tissue microarray immunohistochemistry analysis (TMA-IHC) (n = 280)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938567/gemcitabine-induced-heparanase-promotes-aggressiveness-of-pancreatic-cancer-cells-via-activating-egfr-signaling
#4
Jin-Wen Song, Ying-Xia Tan, Su-Bo Li, Shi-Kun Zhang, Lu-Ming Wan, Shou-Ping Ji, Hong Zhou, Zhi-Hang Zhou, Feng Gong
Pancreatic cancer (PC), characterized by aggressive local invasion and metastasis, is one of the most malignant cancers. Gemcitabine is currently used as the standard drug for the treatment of advanced and metastatic PC, but with limited efficacy. In this study, we demonstrated that gemcitabine increased the expression of heparanase (HPA1), the only known mammalian endoglycosidase capable of cleaving heparan sulfate, both in vitro and in vivo. Furthermore, overexpression of HPA1 in PC cell lines enhanced proliferation and invasion, accompanied with elevated phosphorylation of EGFR...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938565/lncrna-afap1-as1-promotes-growth-and-metastasis-of-cholangiocarcinoma-cells
#5
Xiuhui Shi, Hang Zhang, Min Wang, Xiaodong Xu, Yan Zhao, Ruizhi He, Min Zhang, Min Zhou, Xu Li, Feng Peng, Chengjian Shi, Ming Shen, Xin Wang, Xingjun Guo, Renyi Qin
We investigated the role of actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) lncRNA in promoting cholangiocarcinoma (CCA). qRT-PCR analysis of patient samples showed that AFAP1-AS1 expression was higher in CCA tumors than matched adjacent non-tumor tissue. AFAP1-AS1 levels were also higher in CCA cell lines (HuCCT1 and TFK-1) than a normal biliary epithelium cell line (HIBEpic). AFAP1-AS1 knockdown in CCA cell lines using shAFAP1-AS1 reduced cell proliferation and colony formation in CCK-8 and colony formation assays, respectively...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938538/mir-23a-targets-runx2-and-suppresses-ginsenoside-rg1-induced-angiogenesis-in-endothelial-cells
#6
Xiao-Dong Wu, Ting Guo, Li Liu, Chao Wang, Kun Zhang, Han-Qiang Liu, Feng Wang, Wen-Dong Bai, Meng-Yao Zhang
Rg1 is a predominant protopanaxatriol-type of ginsenoside found in Panax ginseng, and it has been shown to have anti-cancer effects in multiple types of cancer cells. However, Rg1 also induces the expression of proangiogenic factors, such as vascular endothelial growth factor (VEGF-A), in endothelial cells. Unfortunately, angiogenesis positively correlates with cancer development. In this study, we identified RUNX2 as a regulator of ginsenoside Rg1-induced angiogenesis for the first time. We found that RUNX2 was directly targeted and regulated by miR-23a...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938524/microrna-384-represses-the-growth-and-invasion-of-non-small-cell-lung-cancer-by-targeting-astrocyte-elevated-gene-1-wnt-signaling
#7
Na Fan, Jin Zhang, Chuantao Cheng, Xinwu Zhang, Jie Feng, Ranran Kong
Dysregulation of microRNA (miRNA) expression is a critical event in the development and progression of non-small-cell lung cancer (NSCLC). miR-384 has been identified as a novel cancer-related miRNA in numerous cancers, but little is known about its role and functional mechanism in NSCLC. In this study, we found that miR-384 was significantly downregulated in NSCLC tissues and cell lines. The overexpression of miR-384 repressed the growth and invasion of NSCLC cells, whereas its suppression showed the opposite effect...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938513/increased-anterior-default-mode-network-homogeneity-in-first-episode-drug-naive-major-depressive-disorder-a-replication-study
#8
Wenbin Guo, Xilong Cui, Feng Liu, Jindong Chen, Guangrong Xie, Renrong Wu, Zhikun Zhang, Huafu Chen, Jingping Zhao
BACKGROUND: Abnormal default-mode network (DMN) homogeneity has been involved in the neurophysiology of major depressive disorder (MDD) with inconsistent findings. The inconsistency may be due to clinical and methodological variability, and the reproducibility of the findings is limited. The present study aimed to examine alterations of the DMN homogeneity in two independent samples of patients with first-episode, drug-naive MDD. METHODS: The samples included 59 patients with MDD and 31 comparison subjects from Sample 1 and 29 patients with MDD and 24 comparison subjects from Sample 2...
September 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28938178/fabrication-of-mesoporous-magnesium-oxide-nanosheets-using-magnesium-powder-and-their-excellent-adsorption-of-ni-ii
#9
Jing Feng, Mingming Gao, Zhiqiang Zhang, Shengna Liu, Xinyu Zhao, Yueming Ren, Yanzhuo Lv, Zhuangjun Fan
Mesoporous MgO nanosheets with a high adsorption rate and excellent adsorption capacity for removing Ni (II) were successfully synthesized by a hydrothermal and annealing method. The Mg(OH)2 was first synthesized by a hydrothermal process using magnesium powder as the starting material. MgO was then obtained by annealing the as-prepared Mg(OH)2 at 450°C. The advantage of the magnesium powder as the starting material is it slowly generated Mg(2+). Thus, the low centration of Mg(2+) guaranteed a slow rate of forming Mg(OH)2, which benefited with a mesoporous structure...
September 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28937752/inverse-association-between-ambient-sulfur-dioxide-exposure-and-semen-quality-in-wuhan-china
#10
Yuewei Liu, Yun Zhou, Jixuan Ma, Wei Bao, Jingjing Li, Ting Zhou, Xiuqing Cui, Zhe Peng, Hai Zhang, Min Feng, Yuan Yuan, Yuanqi Chen, Xiji Huang, Yonggang Li, Yonggang Duan, Tingming Shi, Lei Jin, Li Wu
Evidence concerning the association between ambient gaseous air pollutant exposures and semen quality is sparse, and findings in previous studies remain largely inconsistent. We enrolled 1759 men with 2184 semen examinations at a large reproductive medical center in Wuhan, China between 2013 and 2015. Inverse distance weighting interpolation was performed to estimate individual exposures to SO2, NO2, CO and O3 during the entire period (lag 0-90 days) and key periods (lag 0-9, 10-14, 70-90 days) of sperm development...
September 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28937648/separation-and-enrichment-of-lectin-from-zihua-snap-bean-phaseolus-vulgaris-seeds-by-peg-600-ammonium-sulfate-aqueous-two-phase-system
#11
Bin Jiang, Yongqiang Yuan, Xiaoqing Zhang, Zhibiao Feng, Chunhong Liu
A fast and efficient method based on a polyethylene glycol (PEG) 600/(NH₄)₂SO₄ aqueous two-phase system for extracting lectin from Zihua snap-bean (Phaseolus vulgaris) seeds was established. According to a Box-Behnken design (BBD), involving four factors at three levels each subjected to analysis of variance (ANOVA) and response surface analysis, the protein recovery and the purification factor of lectin in the top phase were used as the response values of the variance analysis to acquire the multivariate quadratic regression model...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937640/solvent-free-synthesis-and-safener-activity-of-sulfonylurea-benzothiazolines
#12
Ying Fu, Jing-Yi Wang, Dong Zhang, Yu-Feng Chen, Shuang Gao, Li-Xia Zhao, Fei Ye
A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, ¹H-NMR, (13)C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937494/high-pitch-coronary-computed-tomographic-angiography-using-the-third-generation-dual-source-computed-tomography-initial-experience-in-patients-with-high-heart-rate
#13
Ruiqi Feng, Jingsong Mao, Xiaofei Liu, Yu Zhao, Jiajie Tong, Liang Zhang
OBJECTIVE: This study aimed to evaluate the feasibility, image quality, and radiation dose of prospectively high-pitch coronary computed tomographic (CT) angiography in patients with high heart rates (HRs) using the third-generation dual-source CT. METHODS: One hundred consecutive patients with sinus rhythm and HR between 70 and 100 beats per minute were enrolled into this study. All patients were divided into 2 groups. Patients in group A (n = 46) were examined with prospectively high-pitch scan mode in which image acquisition was triggered at 30% of the R-R interval...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937360/strain-engineering-on-transmission-carriers-of-monolayer-phosphorene
#14
Wei Zhang, Feng Li, Junsong Hu, Ping Zhang, Jiuren Yin, Xianqiong Tang, Yong Jiang, Bozhao Wu, Yanhuai Ding
The effects of uniaxial strain on the structure, band gap and transmission carriers of monolayer phosphorene were investigated by first-principles calculations. The strain induced semiconductor-metal as well as direct-indirect transitions is studied in monolayer phosphorene. The position of CBM which belonged to indirect gap shifts along the direction of the applied strain. We have concluded the change rules of the carrier effective mass when plane strains are applied. In band structure, the sudden decrease of band gap or the new formation of CBM (VBM) causes the unexpected change in carrier effective mass...
September 22, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28937033/transcranial-sonographic-alterations-of-substantia-nigra-and-third-ventricle-in-parkinson-s-disease-with-or-without-dementia
#15
Zhi-Fen Dong, Cai-Shan Wang, Ying-Chun Zhang, Ying Zhang, Yu-Jing Sheng, Hua Hu, Wei-Feng Luo, Chun-Feng Liu
BACKGROUND: Numerous studies have demonstrated that patients with Parkinson's disease (PD) have a higher prevalence of substantia nigra (SN) hyperechogenicity compared with controls. Our aim was to explore the neuroimaging characteristics of transcranial sonography (TCS) of patients with PD and those with PD with dementia (PDD). The correlation between the echogenicity of the SN and clinical symptoms in Chinese patients with PDD was also assessed. METHODS: The ratios of SN hyperechogenicity (SN+), maximum sizes of SN+, and widths of third ventricle (TV) were measured using TCS for all the recruited patients...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936980/mir-101a-targeting-ezh2-promotes-the-differentiation-of-goat-skeletal-muscle-satellite-cells
#16
Jun-Tao Li, Wei Zhao, Dan-Dan Li, Jing Feng, Gui Ba, Tian-Zeng Song, Hong-Ping Zhang
miR-101a promotes the differentiation of goat skeletal muscle satellite cells (SMSCs), as we previously reported, but the underpinning mechanism remains to be illuminated. In this study, we predicted the target gene of miR-101a by employing online softwares PicTar, TargetScan and miRanda, and found that enhancer of zeste homologue 2 (EZH2) was targeted by miR-101a. Further we identified that EZH2 contained miR-101a binding sites at its 3'UTR by using the dual-luciferase reporter assay system. In addition, we showed that during SMSC differentiation, the downregulated levels of EZH2 mRNA and protein were accompanied by increasing miR-101a expression via qRT-PCR and Western blot...
September 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28936220/de-novo-assembly-of-the-camellia-nitidissima-transcriptome-reveals-key-genes-of-flower-pigment-biosynthesis
#17
Xingwen Zhou, Jiyuan Li, Yulin Zhu, Sui Ni, Jinling Chen, Xiaojuan Feng, Yunfeng Zhang, Shuangquan Li, Hongguang Zhu, Yuanguang Wen
The golden camellia, Camellia nitidissima Chi., is a well-known ornamental plant that is known as "the queen of camellias" because of its golden yellow flowers. The principal pigments in the flowers are carotenoids and flavonol glycosides. Understanding the biosynthesis of the golden color and its regulation is important in camellia breeding. To obtain a comprehensive understanding of flower development in C. nitidissima, a number of cDNA libraries were independently constructed during flower development. Using the Illumina Hiseq2500 platform, approximately 71...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28936194/the-siesta-habit-is-associated-with-a-decreased-risk-of-rupture-of-intracranial-aneurysms
#18
Huibin Kang, Xin Feng, Baorui Zhang, Erkang Guo, Luyao Wang, Zenghui Qian, Peng Liu, Xiaolong Wen, Wenjuan Xu, Youxiang Li, Chuhan Jiang, Zhongxue Wu, Hongbing Zhang, Aihua Liu
BACKGROUND: Previous studies have examined an association between the siesta habit and hypertension, as well as coronary heart disease. However, the relationship between a siesta and the risk of rupture of an intracranial aneurysm (IA) has not yet been established. We aimed to investigate the effects of a siesta on the risk of rupture of IAs. METHODS: We prospectively enrolled consecutive patients diagnosed with IAs at our hospital between January 2016 and December 2016...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28936163/quercetin-declines-apoptosis-ameliorates-mitochondrial-function-and-improves-retinal-ganglion-cell-survival-and-function-in-in-vivo-model-of-glaucoma-in-rat-and-retinal-ganglion-cell-culture-in-vitro
#19
Feng-Juan Gao, Sheng-Hai Zhang, Ping Xu, Bo-Qi Yang, Rong Zhang, Yun Cheng, Xu-Jiao Zhou, Wan-Jing Huang, Min Wang, Jun-Yi Chen, Xing-Huai Sun, Ji-Hong Wu
Glaucoma is a progressive neuropathy characterized by the loss of retinal ganglion cells (RGCs). Strategies that delay or halt RGC loss have been recognized as potentially beneficial for rescuing vision in glaucoma patients. Quercetin (Qcn) is a natural and important dietary flavonoid compound, widely distributed in fruits and vegetables. Mounting evidence suggests that Qcn has numerous neuroprotective effects. However, whether Qcn exerts neuroprotective effects on RGC in glaucoma is poorly understood. In this study, we investigated the protective effect of Qcn against RGC damage in a rat chronic ocular hypertension (COHT) model invivo and hypoxia-induced primary cultured RGC damage in vitro, and we further explored the underlying neuroprotective mechanisms...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28935762/effect-of-different-anesthetic-methods-on-cellular-immune-functioning-and-the-prognosis-of-patients-with-ovarian-cancer-undergoing-oophorectomy
#20
Xin-Rui Han, Xin Wen, Yan-Yi Li, Shao-Hua Fan, Zi-Feng Zhang, Hong Li, Xing-Feng Sun, Gui-Qi Geng, Shen Sun, Shao-Qiang Huang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study aimed to explore the effects of different anesthetic methods on cellular immune function and prognosis of patients with ovarian cancer (OC) undergoing oophorectomy. A total of 167 patients who received general anesthesia (GA) treatment (GA group) and 154 patients who received combined general/epidural anesthesia (GEA) treatment (GEA group) were collected retrospectively. Each group selected 124 patients that met the inclusion and exclusion criteria for further study. ELISA and radioimmunoassay were employed to detect levels of IL-2, TNF-α and CA-125...
September 21, 2017: Bioscience Reports
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