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Zhang Feng

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https://www.readbyqxmd.com/read/28817810/tgf-%C3%AE-1-is-involved-in-vitamin-d-induced-chondrogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-by-regulating-the-erk-jnk-pathway
#1
Xiaorui Jiang, Botao Huang, Huiying Yang, Guishi Li, Chunlei Zhang, Guangshi Yang, Feng Lin, Guodong Lin
BACKGROUND/AIMS: Osteoarthritis (OA) is characterized by degradation of cartilage, sole cell type of which is chondrocytes. Bone marrow-derived mesenchymal stem cells (BMSCs) possess multipotency and can be directionally differentiated into chondrocytes under stimulation. This study was aimed to explore the possible roles of vitamin D and transforming growth factor-β1 (TGF-β1) in the chondrogenic differentiation of BMSCs. METHODS: BMSCs were isolated from femurs and tibias of rats and characterized by flow cytometry...
August 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28817600/development-and-evaluation-of-height-diameter-at-breast-models-for-native-chinese-metasequoia
#2
Mu Liu, Zhongke Feng, Zhixiang Zhang, Chenghui Ma, Mingming Wang, Bo-Ling Lian, Renjie Sun, Li Zhang
Accurate tree height and diameter at breast height (dbh) are important input variables for growth and yield models. A total of 5503 Chinese Metasequoia trees were used in this study. We studied 53 fitted models, of which 7 were linear models and 46 were non-linear models. These models were divided into two groups of single models and multivariate models according to the number of independent variables. The results show that the allometry equation of tree height which has diameter at breast height as independent variable can better reflect the change of tree height; in addition the prediction accuracy of the multivariate composite models is higher than that of the single variable models...
2017: PloS One
https://www.readbyqxmd.com/read/28817487/inhibiting-protein-tyrosine-phosphatase-1b-to-improve-regenerative-functions-of-endothelial-cells
#3
Yuan Wang, Feng Yan, Wenjing Zhang, Shu Pang, Fan Jiang
Protein tyrosine phosphatase-1B (PTP1B) is an important negative regulator of insulin receptor- and vascular endothelial growth factor receptor-dependent signalings in endothelial cells. Genetic or pharmacological inhibition of PTP1B has been shown to enhance endothelial cell proliferation and migration, and increase nitric oxide production. In vivo, inhibiting PTP1B can reverse endothelial dysfunction, promote angiogenesis, and accelerate wound healing. Intense research is currently continuing in an effort to discover novel selective PTP1B inhibitors, primarily for treating insulin resistance...
August 4, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28817457/a-comparison-by-meta-analysis-of-papillary-early-gastric-carcinoma-to-its-tubular-counterpart-for-the-risk-of-lymph-node-metastasis-and-submucosal-invasion
#4
Xiao-Yong Wang, Jin Yan, Jia Wu, Yi-Feng Zhang, Guo-Xin Zhang
BACKGROUND AND AIM: At present, the decision to perform endoscopic resection for treating either papillary early gastric cancer (EGC) or tubular EGC is made according to identical criteria. However, there is controversy in the literature whether the risk of lymph node metastasis (LNM) and submucosal invasion for both disease modalities is equal, and this prompts investigation to clarify this issue. METHODS: The PubMed and Web of Science databases were searched for relevant studies published up to January 2017...
August 16, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28817203/the-combination-of-digoxin-and-gsk2606414-exerts-synergistic-anticancer-activity-against-leukemia-in-vitro-and-in-vivo
#5
Xue-Hong Zhang, Xin-Yu Wang, Zhi-Wei Zhou, Hua Bai, Lin Shi, Yin-Xue Yang, Shu-Feng Zhou, Xiao-Chun Zhang
Digoxin is a member of cardiac glycosides and recent studies show that digoxin plays anticancer role in several types of cancer. However, the anticancer effects and mechanism of digoxin in leukemia is largely unknown. Her, our data show that digoxin treatment significantly inhibits leukemia cell viability. In addition, digoxin treatment significantly induced apoptosis and G2/M cell cycle arrest in leukemia cells. Furthermore, we demonstrated that digoxin treatment inactivate that oncogenic pathway Akt/mTOR signaling in leukemia cells...
August 17, 2017: BioFactors
https://www.readbyqxmd.com/read/28817075/discrimination-of-transgenic-maize-kernel-using-nir-hyperspectral-imaging-and-multivariate-data-analysis
#6
Xuping Feng, Yiying Zhao, Chu Zhang, Peng Cheng, Yong He
There are possible environmental risks related to gene flow from genetically engineered organisms. It is important to find accurate, fast, and inexpensive methods to detect and monitor the presence of genetically modified (GM) organisms in crops and derived crop products. In the present study, GM maize kernels containing both cry1Ab/cry2Aj-G10evo proteins and their non-GM parents were examined by using hyperspectral imaging in the near-infrared (NIR) range (874.41-1733.91 nm) combined with chemometric data analysis...
August 17, 2017: Sensors
https://www.readbyqxmd.com/read/28816962/relationships-of-capsule-endoscopy-lewis-score-with-clinical-disease-activity-indices-c-reactive-protein-and-small-bowel-transit-time-in-pediatric-and-adult-patients-with-small-bowel-crohn-s-disease
#7
Chengcheng He, Jie Zhang, Zhenyu Chen, Xicheng Feng, Zibin Luo, Tianmo Wan, Aimin Li, Side Liu, Yuexin Ren
Relationships between the capsule endoscopy Lewis score (LS) and clinical disease activity indices and C-reactive protein (CRP) are controversial in adult patients with Crohn's disease (CD). Also, data on pediatric patients are relatively less. However, correlation between LS and small bowel transit time (SBTT) remains investigational. The aim of the present study was to explore the correlations between LS and clinical disease activity indices, CRP, SBTT in pediatric, and adult patients with small bowel CD...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816951/effect-of-therapeutic-care-for-treating-fatigue-in-patients-with-breast-cancer-receiving-chemotherapy
#8
Bing Zhang, Jia-Nan Dong, Ping Sun, Chong Feng, Yan-Cui Liu
BACKGROUND: This study aimed to evaluate the effect of therapeutic care (TC) for fatigue in breast cancer patients receiving chemotherapy. METHODS: A total of 48 breast cancer patients receiving chemotherapy were randomly divided into the intervention group and the control group, with 24 patients in each group. The patients in the intervention group were treated with TC, while the participants in the control group received the sham intervention. The interventions in both groups were for 30 min/d, 3 days weekly for 12 weeks...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816658/discriminative-feature-representation-to-improve-projection-data-inconsistency-for-low-dose-ct-imaging
#9
Jin Liu, Jianhua Ma, Yi Zhang, Yang Chen, Jian Yang, Huazhong Shu, Limin Luo, Gouenou Coatrieux, Wei Yang, Qianjin Feng, Wufan Chen
In low dose computed tomography (LDCT) imaging, the data inconsistency of measured noisy projections can significantly deteriorate reconstruction images. To deal with this problem, we propose here a new sinogram restoration approach, the Sinogram- Discriminative Feature Representation (S-DFR) method. Different from other sinogram restoration methods, the proposed method works through a 3-D representation based feature decomposition of the projected attenuation component and the noise component using a well-designed composite dictionary containing atoms with discriminative features...
August 14, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28816378/correlation-of-the-expressions-of-igf1r-rack1-stat3-and-bcl-xl-in-nasopharyngeal-carcinoma-with-the-clinicopathological-features-and-prognosis-of-nasopharyngeal-carcinoma
#10
Shan Wang, Min Shen, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Xia Ge, Qiu-Mei Lei, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
The aim of this study was to investigate the correlation of expression of IGF1R-RACK1-STAT3 and Bcl-xl in nasopharyngeal carcinoma (NPC) with the clinicopathological features and the prognosis of NPC. Our study selected 215 NPC tissues and 178 chronic nasopharyngitis tissues (control group). Positive expression rates of IGF1R, RACK1, STAT3 and Bcl-xl were tested by immunohistochemical method, and expression of IGF1R, RACK1, STAT3, Bcl-xl, Bcl-2 and Bax by western blotting. Correlation of IGF1R, RACK1, STAT3 and Bcl-xl with the clinicopathological features of NPC was analyzed...
August 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28816041/contact-engineering-of-molybdenum-ditelluride-field-effect-transistors-through-rapid-thermal-annealing
#11
Jiancui Chen, Zhihong Feng, Shuangqing Fan, Sigang Shi, Yuchen Yue, Wanfu Shen, Yuan Xie, Enxiu Wu, Chongling Sun, Jing Liu, Hao Zhang, Wei Pang, Dong Sun, Wei Feng, Yiyu Feng, Sen Wu, Daihua Zhang
Understanding and engineering the interface between metal and two-dimensional materials are of great importance to the research and development of Nano-electronics. In many cases the interface of meal and 2D materials can dominate the transport behavior of the devices. In this study, we focus on the metal contacts of MoTe2 (molybdenum ditelluride) FETs (field effect transistors) and demonstrate how to use post annealing treatment to modulate their transport behaviors in a controlled manner. We have also carried out low temperature and transmission electron microscopy studies to understand the mechanisms behind the prominent effect of the annealing process...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28816019/itraq-based-quantitative-proteomic-analyses-of-high-grade-esophageal-squamous-intraepithelial-neoplasia
#12
Jingjing Zhang, Chunchun Zhi, Fuxi Zhen, Xiaoqin Yuan, Chunhua Jiao, Hong Zhu, Hui Zhu, Yadong Feng
PURPOSE: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and is the fourth most lethal cancer in China. Little is known about the proteome of high grade esophageal squamous intraepithelial neoplasia (HGN), which is a premalignant lesion of ESCC. EXPERIMENTAL DESIGN: A quantitative proteomic analysis using an Isobaric Tags for Relative and Absolute Quantification (iTRAQ) approach was used to characterize the protein expression profiles in HGN...
August 16, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28815898/synthesis-of-bicyclo-n-1-0-alkanes-via-cobalt-catalyzed-multiple-c-sp3-h-activation-strategy
#13
Zhuo-Zhuo Zhang, Ye-Qiang Han, Bei-Bei Zhan, Sai Wang, Bing-Feng Shi
A cobalt-catalyzed dual C(sp3)-H activation strategy has been developed, providing a novel strategy for the synthesis of bicyclo[4.1.0]heptanes and bicyclo[3.1.0]hexanes. A key to the success of this reaction is the conformation-induced methylene C(sp3)-H activation of the resulting cobaltabicyclo[4.n.1] intermediate. In addition, the synthesis of bicyclo[3.1.0]hexane from pivalamide via triple C(sp3)-H activation has also been demonstrated.
August 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28814985/activation-of-endocannabinoid-receptor-2-as-a-mechanism-of-propofol-pretreatment-induced-cardioprotection-against-ischemia-reperfusion-injury-in-rats
#14
Hai-Jing Sun, Yan Lu, Hao-Wei Wang, Hao Zhang, Shuang-Ran Wang, Wen-Yun Xu, Hai-Long Fu, Xue-Ya Yao, Feng Yang, Hong-Bin Yuan
Propofol pretreatment before reperfusion, or propofol conditioning, has been shown to be cardioprotective, while its mechanism is unclear. The current study investigated the roles of endocannabinoid signaling in propofol cardioprotection in an in vivo model of myocardial ischemia/reperfusion (I/R) injury and in in vitro primary cardiomyocyte hypoxia/reoxygenation (H/R) injury. The results showed that propofol conditioning increased both serum and cell culture media concentrations of endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) detected by LC-MS/MS...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28814885/igf2bp3-as-a-potential-tissue-marker-for-the-diagnosis-of-esophageal-high-grade-intraepithelial-neoplasia
#15
Jingjing Zhang, Qing Ji, Chunhua Jiao, Lihua Ren, Ye Zhao, Yanfang Chen, Ruihua Shi, Yadong Feng
BACKGROUND: The clinical significance of insulin-like growth factor-II mRNA-binding protein-3 (IGF2BP3) in esophageal high-grade intraepithelial neoplasia (HGIN) is not clear. This study was designed to characterize the expression of IGF2BP3 in HGIN. PATIENTS AND METHODS: IGF2BP3 expression was evaluated by Western blot analyses in 12 cases and by immunohistochemistry (IHC) in 112 cases. The associations between IGF2BP3 expression in HGIN and the clinicopathological parameters were examined...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28814873/safety-and-efficacy-of-paliperidone-palmitate-1-month-formulation-in-chinese-patients-with-schizophrenia-a-25-week-open-label-multicenter-phase-iv-study
#16
Jingping Zhao, Lehua Li, Jianguo Shi, Yi Li, Xiufeng Xu, Keqing Li, Lili Zhang, Shangli Cai, Yu Feng, Jianmin Zhuo, Weihong Liu, Huafei Lu
RATIONALE: Long-acting injectable (LAI) paliperidone palmitate 1-month formulation (PP1M) has demonstrated acceptable tolerability and favorable clinical outcomes in Western and Asian patients with schizophrenia. Hence, analysis of the outcomes of long-term PP1M treatment specifically in Chinese patients is of interest. OBJECTIVE: The aim of this study is to evaluate the long-term safety and efficacy of PP1M treatment in Chinese patients with schizophrenia. METHODS: In this 25-week, open-label, Phase IV study, patients (18-65 years) diagnosed with schizophrenia and having a baseline Positive and Negative Syndrome Scale (PANSS) total score of 60-120 (inclusive) were enrolled...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28814756/giant-pandas-can-discriminate-the-emotions-of-human-facial-pictures
#17
Youxu Li, Qiang Dai, Rong Hou, Zhihe Zhang, Peng Chen, Rui Xue, Feifei Feng, Chao Chen, Jiabin Liu, Xiaodong Gu, Zejun Zhang, Dunwu Qi
Previous studies have shown that giant pandas (Ailuropoda melanoleuca) can discriminate face-like shapes, but little is known about their cognitive ability with respect to the emotional expressions of humans. We tested whether adult giant pandas can discriminate expressions from pictures of half of a face and found that pandas can learn to discriminate between angry and happy expressions based on global information from the whole face. Young adult pandas (5-7 years old) learned to discriminate expressions more quickly than older individuals (8-16 years old), but no significant differences were found between females and males...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814642/an-indel-in-the-promoter-of-al-activated-malate-transporter-9-selected-during-tomato-domestication-determines-fruit-malate-contents-and-aluminum-tolerance
#18
Jie Ye, Xin Wang, Ti Xu Hu, Feng Xia Zhang, Bing Wang, Chang Xin Li, Tian Xia Yang, Han Xia Li, Yong En Lu, James J Giovannoni, Yuyang Zhang, Zhibiao Ye
Deciphering the mechanism of malate accumulation in plants would contribute to a greater understanding of plant chemistry, which has implications for improving flavor quality in crop species and enhancing human health benefits. However, the regulation of malate metabolism is poorly understood in crops such as tomato (Solanum lycopersicum). Here, we integrated a metabolite-based genome-wide association study (mGWAS) with linkage mapping and gene functional studies to characterize the genetics of malate accumulation in a global collection of tomato accessions with broad genetic diversity...
August 16, 2017: Plant Cell
https://www.readbyqxmd.com/read/28814522/characterization-of-cis-acting-rna-elements-of-zika-virus-by-using-a-self-splicing-ribozyme-dependent-infectious-clone
#19
Zhong-Yu Liu, Jiu-Yang Yu, Xing-Yao Huang, Hang Fan, Xiao-Feng Li, Yong-Qiang Deng, Xue Ji, Meng-Li Cheng, Qing Ye, Hui Zhao, Jian-Feng Han, Xiao-Ping An, Tao Jiang, Bo Zhang, Yi-Gang Tong, Cheng-Feng Qin
Zika virus (ZIKV) has caused significant outbreaks and epidemics in the Americas recently, raising global concern due to its ability to cause microcephaly and other neurological complications. A stable and efficient infectious clone of ZIKV is urgently needed. However, the instability and toxicity of flavivirus cDNA clones in E. coli hosts has hindered the development of ZIKV infectious clones. Herein, using a novel self-splicing ribozyme-based strategy, we have generated a stable infectious cDNA clone of a contemporary ZIKV strain imported from Venezuela to China in 2016...
August 16, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28814300/increasing-on-target-cleavage-efficiency-for-crispr-cas9-induced-large-fragment-deletion-in-myxococcus-xanthus
#20
Ying-Jie Yang, Ye Wang, Zhi-Feng Li, Ya Gong, Peng Zhang, Wen-Chao Hu, Duo-Hong Sheng, Yue-Zhong Li
BACKGROUND: The CRISPR/Cas9 system is a powerful tool for genome editing, in which the sgRNA binds and guides the Cas9 protein for the sequence-specific cleavage. The protocol is employable in different organisms, but is often limited by cell damage due to the endonuclease activity of the introduced Cas9 and the potential off-target DNA cleavage from incorrect guide by the 20 nt spacer. RESULTS: In this study, after resolving some critical limits, we have established an efficient CRISPR/Cas9 system for the deletion of large genome fragments related to the biosynthesis of secondary metabolites in Myxococcus xanthus cells...
August 16, 2017: Microbial Cell Factories
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