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https://www.readbyqxmd.com/read/28449478/protective-effect-of-propofol-preconditioning-on-ischemia-reperfusion-injury-in-human-hepatocyte
#1
Yuzhu Zhang, Zhenzhen Chen, Nianhai Feng, Junxia Tang, Xingbo Zhao, Chengxiao Liu, Hongyu Xu, Mengyuan Zhang
BACKGROUND: Blood reperfusion after ischemia is the main measure to restore cell function. This study was aimed to explore the effect of propofol on rat and cell models of liver ischemia-reperfusion (I/R) injury, and to investigate its possible mechanism. METHODS: Wistar rats were divided into four groups: control group, sham group, I/R group, and propofol group. Human hepatocyte HL7702 was divided into six groups: control group, I/R group and propofol (5, 10, 20 and 40 µmol/L) groups...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449035/identification-and-expression-profiling-of-odorant-binding-proteins-and-chemosensory-proteins-of-daktulosphaira-vitifoliae-hemiptera-phylloxeridae
#2
Jing-Jing Zhao, Yue Zhang, Dong-Sheng Fan, Ji-Nian Feng
In insects, odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) are primary peripheral olfactory proteins playing critical roles in odorant detection. In this study, we present the first identification of OBPs and CSPs from the transcriptome of grape phylloxera Daktulosphaira vitifoliae Fitch, an important pest that damages both roots and leaves of grapes. The OBPs contained six conserved cysteine residues and the CSPs contained four conserved cysteine residues in this insect. Phylogenetic analysis showed that most of the olfactory proteins were closely related to OBPs and CSPs from other aphids...
April 25, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28448974/the-feasibility-and-safety-of-interventional-occlusion-treatment-of-intracristal-ventricular-septal-defects-clinical-report-of-56-cases
#3
Ting Cui, Wanfeng Sun, Yanhong He, Guopei Zhang, Dajie Wang, Yudong Xia, Feng Wang, Mingxing Zhu
BACKGROUND: To investigate the feasibility and safety of the O eccentric shape occluder in the interventional occlusion treatment of intracristal ventricular septal defect (IVSD). METHODS: A retrospective analysis of the clinical data of 56 IVSD patients treated by interventional occlusion at our center, as well as recording of their intraoperative and postoperative status, was performed. RESULTS: Of the 56 patients, a total of 48 patients underwent successful occlusion during the first surgical attempt...
April 28, 2017: Cardiology
https://www.readbyqxmd.com/read/28448908/biological-impacts-of-glyphosate-on-morphology-embryo-biomechanics-and-larval-behavior-in-zebrafish-danio-rerio
#4
Shuhui Zhang, Jia Xu, Xiangyu Kuang, Shibao Li, Xiang Li, Dongyan Chen, Xin Zhao, Xizeng Feng
All of these days, residues of herbicides such as glyphosate are widely distributed in the environment. The ubiquitous use of glyphosate has drawn extensive attention to its toxicity as an organic pollutant. In this study, we employed larval zebrafish as an animal model to evaluate the effect of different concentrations of glyphosate on early development via morphological, biomechanics, behavioral and physiological analyses. Morphological results showed that an obvious delay occurred in the epiboly process and body length, eye and head area were reduced at concentrations higher than 10 mg/L...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448787/relationship-between-her2-and-jak-stat-socs3-signaling-pathway-and-clinicopathological-features-and-prognosis-of-ovarian-cancer
#5
An-Quan Shang, Jian Wu, Feng Bi, Yu-Jie Zhang, Lei-Rong Xu, Ling-Ling Li, Fei-Fei Chen, Wei-Wei Wang, Jian-Jun Zhu, You-Yi Liu
OBJECTIVE: The study aims to explore the relationship between expressions of HER2 and JAK/STAT3-SOCS3 signaling pathway and clinicopathological features and prognosis of ovarian cancer (OC). METHODS: A total of 136 OC patients were collected. Immunohistochemistry was applied to measure the expressions of STAT3, p-STAT3, SOCS3, HER2 and p-HER2 in the tumor tissues and adjacent normal tissues. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the mRNA expressions of HER2, SOCS3 and STAT3 and western blotting was applied for protein expressions of HER2, p-HER2, SOCS3, STAT3 and p-STAT3 in the tumor tissues and adjacent normal tissues...
April 27, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28447793/hydrogen-peroxide-induced-change-in-meat-quality-of-breast-muscle-of-broilers-is-mediated-by-ros-generation-apoptosis-and-autophagy-in-nf-%C3%AE%C2%BAb-signal-pathway
#6
Xiangxing Chen, Lin Zhang, Jiaolong Li, Feng Gao, Guanghong Zhou
We investigated the relationship between meat quality and oxidative damage caused by hydrogen peroxide (H2O2) in the breast muscle of broilers. Moreover, we explored the occurrence of apoptosis and autophagy, as well as the expression of NF-κB in these signaling pathways, to provide evidence of possible oxidative damage mechanisms. The broilers received a basal diet and were randomly divided into five treatments (non-injected control, 0.75% saline-injected, and 2.5%, 5.0%, or 10.0% H2O2-injected treatments; 1...
April 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28447790/improvement-of-photovoltaic-performance-of-colloidal-quantum-dot-solar-cells-using-organic-small-molecule-as-hole-selective-layer
#7
Yaohong Zhang, Guohua Wu, Ivan Mora-Sero, Chao Ding, Feng Liu, Qingxun Huang, Yuhei Ogomi, Shuzi Hayase, Taro Toyoda, Ruixiang Wang, Joe Otsuki, Qing Shen
A novel organic small molecule bis-triphenylamine with spiro(fluorene-9,9'-xanthene) as the conjugated system, named BTPA-4, is successfully synthesized and employed as the hole-selective layer (HSL) in colloidal quantum dots solar cells (CQDSCs). The introduction of BTPA-4 layer can significantly prolong effective carrier lifetime (τeff), increase charge recombination resistance (Rrec), and thus diminish the interfacial charge recombination at the PbS-QDs/Au electrode interface. The effect of BTPA-4 as HSL in the device performance is especially significant for the open-circuit voltage (Voc) and power conversion efficiency (PCE), with a ~ 10% and 15% enhancement respectively, comparing with those of device without the HSL...
April 27, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28447774/nitrogen-and-phosphorus-codoped-mesoporous-carbon-derived-from-polypyrrole-as-superior-metal-free-electrocatalyst-towards-the-oxygen-reduction-reaction
#8
Zhengping Zhang, Junting Sun, Meiling Dou, Jing Ji, Feng Wang
To replace high-cost platinum group metal (PGM) electrocatalysts for oxygen reduction reaction (ORR) that is the crucial cathode reaction in fuel cell technology and metal-air battery, the development of low-cost and high-efficiency non-PGM catalysts for ORR has attracted much attention during the past decades. As one of the promising candidates, the N-doped carbon is highly desirable for its strong designability and outstanding catalytic activity and stability. In this work, a facile and rational strategy is demonstrated for preparation of N, P-codoped mesoporous carbon (N,P-MC) for ORR by the direct pyrolysis treatment of polypyrrole with phytic acid as P-dopant and polystyrene sphere as template...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28447756/matrine-reduces-the-proliferation-of-a549%C3%A2-cells-via-the-p53-p21-pcna-eif4e-signaling-pathway
#9
Zhiyan Lu, Youzhang Xiao, Xing Liu, Zaipeng Zhang, Feng Xiao, Yongyi Bi
The aim of the present study was to investigate how matrine affects the proliferation of A549 human lung adenocarcinoma cells via the p53/p21/proliferating cell nuclear antigen (PCNA)/eukaryotic translation initiation factor 4E (eIF4E) signaling pathway. The effect of different concentrations of matrine on the proliferation of A549 cells was investigated using a 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide (MTT) assay. The migration of A549 cells following exposure to varied concentrations of matrine was detected using a Transwell cell migration assay...
March 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447460/effects-of-histidine-supplementation-on-global-serum-and-urine-1h-nmr-based-metabolomics-and-serum-amino-acid-profiles-in-obese-women-from-a-randomized-controlled-study
#10
Shanshan Du, Shuhong Sun, Liyan Liu, Qiao Zhang, Fuchuan Guo, Chunlong Li, Rennan Feng, Changhao Sun
The aim of current study was to investigate the metabolic changes associated with histidine supplementation in serum and urine metabolic signatures and serum amino acid (AA) profiles. Serum and urine 1H NMR-based metabolomics and serum AAs profiles were employed in thirty two and thirty seven obese women with metabolic syndrome (MetS) intervened with placebo or histidine for 12 weeks. Multivariable statistical analysis were conducted to define characteristic metabolites. In serum 1H NMR metabolic profiles, increases in histidine, glutamine, aspartate, glycine, choline, and trimethylamine-N-oxide (TMAO) were observed, meanwhile, decreases in cholesterol, triglycerides, fatty acids and unsaturated lipids, acetone, and α/β-Glucose were exhibited after histidine supplement...
April 27, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28447457/co3o4-%C3%AE-quantum-dots-as-a-highly-efficient-oxygen-evolution-reaction-catalyst-for-water-splitting
#11
Guangxing Zhang, Jie Yang, Han Wang, Haibiao Chen, Jinlong Yang, Feng Pan
Co3O4-δ quantum dots (Co3O4-δ-QDs) with a crystallite size of approximately 2 nm and oxygen vacancies were fabricated through multicycle lithiation/delithiation of mesoporous Co3O4 nanosheets. Used as an oxygen evolution reaction (OER) electrocatalyst for water splitting, the catalytic performance (an overpotential of 270 mV@10 mA cm-2 and no decay within 30 h) of Co3O4-δ-QDs is superior to that of previously reported Co-based catalysts and the state-of-the-art IrO2. Compared with the Co3O4 nanosheets, the enhanced OER activity of Co3O4-δ-QDs is attributed to two factors: one is the increased quantity of the Faradaic active sites, including the total active sites (q*Total), the most accessible active sites (q*Outer) and their ratio (q*Outer/q*Total); the other is the enhanced intrinsic electroactivity per active site evaluated by the turnover frequency (TOF) and the current density normalized by the most accessible active sites (j/q*Outer) related to OER...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28447291/investigation-of-contact-characteristics-and-frictional-properties-of-natural-articular-cartilage-at-two-different-surface-configurations
#12
Shanhua Qian, Liyong Zhang, Zi Feng Ni, Chuanhui Huang, Dekun Zhang
Natural cartilage surfaces were macroscopically curved with multi-porous viscoelastic biologic materials with extremely high water, but whether curved surface configuration could play an important role on the contact and frictional properties of natural cartilages fails to be completely understood up to now. In this current study, cartilage samples came from the 18-24 month-old bovine femora. Contact characteristic and frictional properties at two cartilage configurations were investigated using the UMT-2 testing rig and the five-point sliding average method would be adopted to analyze these tested data...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28446882/modified-low-dose-triiodo-l-thyronine-therapy-safely-improves-function-following-myocardial-ischemia-reperfusion-injury
#13
Viswanathan Rajagopalan, Youhua Zhang, Christine Pol, Clifford Costello, Samantha Seitter, Ann Lehto, Olga V Savinova, Yue-Feng Chen, A Martin Gerdes
Background: We have shown that thyroid hormones (THs) are cardioprotective and can be potentially used as safe therapeutic agents for diabetic cardiomyopathy and permanent infarction. However, no reliable, clinically translatable protocol exists for TH treatment of myocardial ischemia-reperfusion (IR) injury. We hypothesized that modified low-dose triiodo-L-thyronine (T3) therapy would confer safe therapeutic benefits against IR injury. Methods: Adult female rats underwent left coronary artery ligation for 60 min or sham surgeries...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28446717/gemcitabine-induced-heparanase-promotes-aggressiveness-of-pancreatic-cancer-cells-via-activating-egfr-signaling
#14
Jin-Wen Song, Ying-Xia Tan, Su-Bo Li, Shi-Kun Zhang, Lu-Ming Wan, Shou-Ping Ji, Hong Zhou, Zhi-Hang Zhou, Feng Gong
Pancreatic cancer (PC), characterized by aggressive local invasion and metastasis, is one of the most malignant cancers. Gemcitabine is currently used as the standard drug for the treatment of advanced and metastatic PC, but with limited efficacy. In this study, we demonstrated that gemcitabine increased the expression of heparanase (HPA1), the only known mammalian endoglycosidase capable of cleaving heparan sulfate, both in vitro and in vivo. Furthermore, overexpression of HPA1 in PC cell lines enhanced proliferation and invasion, accompanied with elevated phosphorylation of EGFR...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28446676/grass-carp-reovirus-vp41-targets-fish-mita-to-abrogate-the-ifn-response
#15
Long-Feng Lu, Shun Li, Zhao-Xi Wang, Si-Qi Du, Dan-Dan Chen, Pin Nie, Yong-An Zhang
Although fish possess an efficient interferon (IFN) system to defend against aquatic virus infection, the grass carp reovirus (GCRV) still causes hemorrhagic disease in grass carp. To date, GCRV's strategy for evading the fish IFN response is still unknown. Here, we report that the GCRV VP41 inhibits fish IFN production by suppressing the phosphorylation of the mediator of IRF3 activation (MITA). First, the activation of the IFN promoter (IFNpro) stimulated by the mitochondrial antiviral signaling protein (MAVS) and MITA was decreased by the overexpression of VP41, whereas such activation induced by TANK-binding kinase 1 (TBK1) was not affected...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28446313/-effect-of-agkistrodon-acutus-venom-pca-on-huvec-activity
#16
Jin-Feng Sang, Gen-Bao Zhang, Shu-Yan Zhou, Na Ji
OBJECTIVE: To investigate the effects of Agkistrodon acutus venom protein C activator(PCA) on ultrastructure of human umbilical vein endothelial cells(HUVEC), and the levels of tissue factor(TF), vascular von Willebrand factor (vWF) and endothelin-1 secreted by HUVEC and to clarify the anti-thrombotic mechanism of PCA. METHODS: The experiments were divided into control group(DMEM), LPS group (LPS 0.1 µg/ml), PCA group(PCA 1 µg/ml) and PCA+LPS group (1 µg/ml PCA+ 0...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28446183/effect-of-different-artificial-shrinkage-methods-when-applied-before-blastocyst-vitrification-on-perinatal-outcomes
#17
Caizhu Wang, Guixue Feng, Bo Zhang, Hong Zhou, Jinhui Shu, Ruoyun Lin, Huanhua Chen, Zhulian Wu
BACKGROUND: In recent years, single blastocyst transfer combined with vitrification has been applied widely, which can maximize the cumulative pregnancy rate in per oocyte retrieval cycles and minimize the multiple pregnancy rate. Thus, the guarantee for these is the effectiveness of vitrified blastocyst. Studies has shown that AS of the blastocoel cavity prior to vitrification can reduce injuries, increase the thawed blastocyst survival rate and implantation rate. Several AS methods have been established...
April 26, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28446149/effect-of-genetic-variants-and-traits-related-to-glucose-metabolism-and-their-interaction-with-obesity-on-breast-and-colorectal-cancer-risk-among-postmenopausal-women
#18
Su Yon Jung, Eric M Sobel, Jeanette C Papp, Zuo-Feng Zhang
BACKGROUND: Impaired glucose metabolism-related genetic variants and traits likely interact with obesity and related lifestyle factors, influencing postmenopausal breast and colorectal cancer (CRC), but their interconnected pathways are not fully understood. By stratifying via obesity and lifestyles, we partitioned the total effect of glucose metabolism genetic variants on cancer risk into two putative mechanisms: 1) indirect (risk-associated glucose metabolism genetic variants mediated by glucose metabolism traits) and 2) direct (risk-associated glucose metabolism genetic variants through pathways other than glucose metabolism traits) effects...
April 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28446129/novel-predictors-of-neurosyphilis-among-hiv-negative-syphilis-patients-with-neurological-symptoms-an-observational-study
#19
Yao Xiao, Man-Li Tong, Li-Li Liu, Li-Rong Lin, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Hui-Qin Xing, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteristics, particularly those with neurological symptoms. This study aimed to identify novel predictors of HIV-negative symptomatic neurosyphilis (S-NS). METHODS: From June 2005 to June 2015, 370 HIV-negative syphilis patients with neurological symptoms were recruited, consisting of 191 S-NS patients (including 123 confirmed neurosyphilis and 68 probable neurosyphilis patients) and 179 syphilis/non-neurosyphilis (N-NS) patients...
April 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28445983/transport-stress-induces-weight-loss-and-heart-injury-in-chicks-disruption-of-ionic-homeostasis-via-modulating-ion-transporting-atpases
#20
Zhao-Yang Li, Jia Lin, Feng Sun, Hui Li, Jun Xia, Xue-Nan Li, Jing Ge, Cong Zhang, Jin-Long Li
Transportation is inevitable in the poultry industry, and it can induce stress to chicks in varying degrees, such as mild discomfort, sometimes even death. However, the research about the effects of transport stress on the weight loss and heart injury of chicks is lacking. To elucidate the underlying mechanism of transport stress-induced effects, chicks were transported for 2h, 4h and 8h. The creatinine kinase (CK) activities, the ionic contents, the ATPases activities and the transcription of the ATPase associated subunits in chick heart were detected...
April 11, 2017: Oncotarget
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