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https://www.readbyqxmd.com/read/28169076/metabolites-as-biomarkers-of-adverse-reactions-following-vaccination-a-pilot-study-using-nuclear-magnetic-resonance-metabolomics
#1
Bruce M McClenathan, Delisha A Stewart, Christina E Spooner, Wimal W Pathmasiri, Jason P Burgess, Susan L McRitchie, Y Sammy Choi, Susan C J Sumner
An Adverse Event Following Immunization (AEFI) is an adverse reaction to a vaccination that goes above and beyond the usual side effects associated with vaccinations. One serious AEFI related to the smallpox vaccine is myopericarditis. Metabolomics involves the study of the low molecular weight metabolite profile of cells, tissues, and biological fluids, and provides a functional readout of the phenotype. Metabolomics may help identify a particular metabolic signature in serum of subjects who are predisposed to developing AEFIs...
March 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28123193/5-aminosalicylic-acid-associated-myocarditis-and-pericarditis-a-narrative-review
#2
REVIEW
Glen Brown
BACKGROUND: Use of medications containing the 5-aminosalicylic acid (5-ASA) moiety may cause a rare but potentially lethal side effect involving inflammation of the heart (myocarditis) or pericardium (pericarditis) or both (myopericarditis). Early recognition of 5-ASA as the cause is important to prevent progression of the inflammation. OBJECTIVE: To provide clinicians with information to assist in recognizing the signs and symptoms of 5-ASA-induced cardiac inflammation and the characteristics of the suspected therapy, and in determining the appropriate approach to treatment...
November 2016: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28068282/serological-and-molecular-biological-studies-of-parvovirus-b19-coxsackie-b-viruses-and-adenoviruses-as-potential-cardiotropic-viruses-in-bulgaria
#3
Stefka Kr Ivanova, Svetla G Angelova, Asya P Stoyanova, Irina L Georgieva, Lubomira K Nikolaeva-Glomb, Zafira G Mihneva, Neli St Korsun
BACKGROUND: Inflammatory diseases of the heart (myocarditis, pericarditis) are commonly caused by viruses. Among the human cardiotropic viruses, parvovirus B19, Coxsackie B viruses, and adenoviruses play a leading role. AIM: The aim of the present study was to determine the presumptive causative role of parvovirus B19, Coxsackie B viruses, and adenoviruses in the development of myocarditis, pericarditis and dilated cardiomyopathy by demonstrating the presence of specific antiviral antibodies or viral DNA in patients' serum samples...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28056838/first-case-report-of-myopericarditis-linked-to-campylobacter-coli-enterocolitis
#4
Cameron R M Moffatt, Soniah B Moloi, Karina J Kennedy
BACKGROUND: Campylobacter spp. are a common cause of mostly self-limiting enterocolitis. Although rare, pericarditis and myopericarditis have been increasingly documented as complications following campylobacteriosis. Such cases have occurred predominantly in younger males, and involved a single causative species, namely Campylobacter jejuni. We report the first case of myopericarditis following Campylobacter coli enterocolitis, with illness occurring in an immunocompetent middle-aged female...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28003913/a-rare-case-of-primary-meningococcal-myopericarditis-in-a-71-year-old-male
#5
Odilia I Woudstra, Gerard J J Boink, Jacobus A Winkelman, Ron van Stralen
We describe a case of primary meningococcal C pericarditis with myocardial involvement in a 71-year-old male that is thus far the oldest patient with isolated meningococcal pericardial disease and only the third patient with primary meningococcal myopericarditis described in English literature. Our patient was successfully treated by full sternotomy and surgical drainage combined with intravenous ceftriaxone. Mild symptoms unresponsive to anti-inflammatory treatment and leukocytosis may guide clinicians towards the correct diagnosis...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27939516/nonrheumatic-myopericarditis-post-acute-streptococcal-pharyngitis-an-uncommon-cause-of-sore-throat-with-st-segment-elevation
#6
Ali Pourmand, Daniel Gelman, Steven Davis, Hamid Shokoohi
Nonrheumatic myopericarditis is an uncommon complication of acute pharyngitis caused by Group A Streptococcal infection (GAS). While the natural history of carditis complicating acute rheumatic fever is well established, the incidence, pathophysiology and clinical course of nonrheumatic myopericarditis are ill defined. Advances in rapid bedside testing for both myocardial injury and GAS pharyngitis have allowed for increasing recognition of this uncommon complication in patients presenting with a sore throat with associated chest discomfort...
December 8, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27919176/recurrent-acute-myopericarditis-without-effusion-during-atra-induction-and-ato-salvage-of-apl-a-variant-form-of-the-differentiation-syndrome
#7
Theodoros P Vassilakopoulos, John V Asimakopoulos, Eleni Plata, Glafcos Kelepesis, Kyriaki Petevi, Catherine Koutsi, Loula Papageorgiou, Panayiotis Tsaftaridis, Maria K Angelopoulou, Konstantinos Konstantopoulos, John Meletis
No abstract text is available yet for this article.
December 6, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27909484/lyme-arrhythmia-in-an-avid-golfer-a-diagnostic-challenge-and-a-therapeutic-dilemma
#8
Ujjwal Rastogi, Dr Nidhi Kumars
Lyme disease is a multisystem disorder affecting dermatologic, cardiac, nervous and musculoskeletal systems. Cardiac manifestations occur in about 5% of Lyme infections and stem from the involvement of the cardiac conduction system, resulting in varying degrees of sino-atrioventricular block. Occasionally, Lyme infection may also present with myopericarditis. Unlike isolated conduction node disease, myocardial involvement presents a great diagnostic and therapeutic dilemma for the physician. We report the case of a 68 year-old male cardiologist who presented with new onset exertional dyspnea and palpitations...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27890880/myopericarditis-in-a-case-of-anti-signal-recognition-particle-anti-srp-antibody-positive-myopathy
#9
Mariko Tanaka, Naoki Gamou, Hirohiko Shizukawa, Emiko Tsuda, Shun Shimohama
A 79 year-old female was admitted to our hospital because of high serum creatine kinase level together with proximal muscle weakness and pain on grasping. MRI revealed inflammatory changes in femoral muscles on both sides. Muscle biopsy showed size irregularity of muscle cells, and necrosis and regeneration of fibers. Study of antibodies was also consistent with the diagnostic criteria of anti-signal recognition particle (anti-SRP) antibody-positive myopathy. On admission, the patient required pericardiocentesis for the management of exudative pericarditis...
November 25, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27836311/sex-based-differences-in-prevalence-and-clinical-presentation-among-pericarditis-and-myopericarditis-patients
#10
Michal Laufer-Perl, Ofer Havakuk, Yacov Shacham, Arie Steinvil, Sivan Letourneau-Shesaf, Ehud Chorin, Gad Keren, Yaron Arbel
BACKGROUND: Sex differences in heart diseases, including acute coronary syndrome, congestive heart failure, and atrial fibrillation, have been studied extensively. However, data are lacking regarding sex differences in pericarditis and myopericarditis patients. OBJECTIVES: The purpose of the study was to evaluate whether there are sex differences in pericarditis and myopericarditis patients as well. METHODS: We performed a retrospective, single-center observational study that included 200 consecutive patients hospitalized with idiopathic pericarditis or myopericarditis from January 2012 to April 2014...
October 18, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27751313/varicella-myopericarditis-mimicking-acute-myocardial-infarction-with-ards-a-rare-association-in-an-immunocompetent-young-adult
#11
Mayuresh Chaudhari, Sonu Sharma, Rajesh Kumar Jha, Ramandeep Singh Ahuja, Sandeep Bansal
Primary varicella infection in an immunocompetent young adult is very rare, but it has a high mortality rate due to serious complications. We report a rare association of varicella pneumonia presenting in acute respiratory distress with mild chest pain, however with electrocardiographic and biochemical markers suggestive of acute ST elevation myocardial infarction. Coronary angiography was done to exclude infarction, serum antibody titers confirmed varicella, acyclovir was started, and ARDS was successfully treated with steroid pulse therapy and mechanical ventilator support...
September 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27490723/subacute-myopericarditis-without-myocardial-infarction-treated-with-intravenous-immunoglobulin-in-a-child-with-marked-elevation-of-plasma-cardiac-troponin-i
#12
Gabriella De Rosa, Antonio Gatto, Silvia Triarico, Marco Piastra, Piero Valentini, Valentina Giorgio, Ilaria Lazzareschi, Donato Rigante
No abstract text is available yet for this article.
August 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27368743/imaging-diagnoses-and-outcome-in-patients-presenting-for-primary-angioplasty-but-no-obstructive-coronary-artery-disease
#13
Tarun K Mittal, Luise Reichmuth, Ben Ariff, Praveen P G Rao, Aigul Baltabaeva, Shelley Rahman-Haley, Tito Kabir, Joyce Wong, Miles Dalby
OBJECTIVE: A proportion of patients with suspected ST-elevation myocardial infarction (STEMI) presenting for primary percutaneous coronary intervention (PPCI) do not have obstructive coronary disease and other conditions may be responsible for their symptoms and ECG changes. In this study, we set out to determine the prevalence and aetiology of alternative diagnoses in a large PPCI cohort as determined with multimodality imaging and their outcome. METHODS: From 2009 to 2012, 5238 patients with suspected STEMI were referred for consideration of PPCI...
November 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27358529/cardiovascular-complications-among-individuals-with-amphetamine-positive-urine-drug-screening-admitted-to-a-tertiary-care-hospital-in-riyadh
#14
Mohammad Alghamdi, Bader Alqahtani, Sultan Alhowti
BACKGROUND: Amphetamine-type stimulants (ATS) are the most commonly used illicit drugs in Saudi Arabia. Frequency and outcome of ATS-related cardiovascular (CV) complications in the Saudi community have not been previously studied. AIM: We aimed to determine the incidence and the clinical outcomes of CV complications among individuals with amphetamine-positive urine drug screening (APUDS) tests admitted to a tertiary care facility in Riyadh, Saudi Arabia. METHODS: Retrospective review of consecutive cases with APUDS and concurrently positive cardiac biomarkers admitted to King Abdul-Aziz Medical City in Riyadh, Saudi Arabia, between January 2006 and December 2013...
July 2016: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/27327616/a-randomized-double-blind-placebo-controlled-phase-ii-trial-investigating-the-safety-and-immunogenicity-of-modified-vaccinia-ankara-smallpox-vaccine-mva-bn%C3%A2-in-56-80-year-old-subjects
#15
Richard N Greenberg, Christine M Hay, Jack T Stapleton, Thomas C Marbury, Eva Wagner, Eva Kreitmeir, Siegfried Röesch, Alfred von Krempelhuber, Philip Young, Richard Nichols, Thomas P Meyer, Darja Schmidt, Josef Weigl, Garth Virgin, Nathaly Arndtz-Wiedemann, Paul Chaplin
BACKGROUND: Modified Vaccinia Ankara MVA-BN® is a live, highly attenuated, viral vaccine under advanced development as a non-replicating smallpox vaccine. In this Phase II trial, the safety and immunogenicity of Modified Vaccinia Ankara MVA-BN® (MVA) was assessed in a 56-80 years old population. METHODS: MVA with a virus titer of 1 x 108 TCID50/dose was administered via subcutaneous injection to 56-80 year old vaccinia-experienced subjects (N = 120). Subjects received either two injections of MVA (MM group) or one injection of Placebo and one injection of MVA (PM group) four weeks apart...
2016: PloS One
https://www.readbyqxmd.com/read/27299147/focal-myopericarditis-as-a-rare-but-important-differential-diagnosis-of-myocardial-infarction-a-case-series
#16
Younes Nozari, Masih Tajdini, Mehdi Mehrani, Rosa Ghaderpanah
Distinguishing ST-elevation myocardial infarction (STEMI) differential diagnoses is more challenging. Myopericarditis is one of these differentials that results from viral involvement of myocardium and pericardium of the heart. Myopericarditis in focal form can mimic acute STEMI in its electrocardiogram (ECG) features and elevated cardiac enzymes. Myocarditis patients may face thrombolytic related complications such as intracranial bleeding, myocardial rupture, and hemorrhagic cardiac tamponade. Furthermore, re-administration of streptokinase (a common thrombolytic agent in our country) is banned for at least six months of previous administration; however, it can save patients' lives in emergency conditions such as massive pulmonary embolism...
2016: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/27284323/acute-tuberculous-myopericarditis-mimicking-acute-myocardial-infarction-a-case-report-and-literature-review
#17
Manyi Ren, Chunsheng Zhang, Xiaojuan Zhang, Jingquan Zhong
A number of cases of acute myopericarditis mimicking acute myocardial infarction (AMI) have previously been reported in the literature. However, to the best of our knowledge, such a case resulting from Mycobacterium tuberculosis infection has not previously been described. The present study reports the case of a 21-year-old male patient presenting with acute chest pain, in whom focal ST-segment elevation and elevated cardiac enzymes mimicked a diagnosis of AMI. However, acute tuberculous myopericarditis was diagnosed on the basis of a variety of imaging examinations, laboratory tests, as well as the changes observed in electrocardiograms (ECGs) and in the cardiac enzyme levels...
June 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27270692/acute-onset-myopericarditis-as-unusual-presentation-of-primary-hiv-infection
#18
Giacomo Vandi, Leonardo Calza, Nicolò Girometti, Roberto Manfredi, Giuseppina Musumeci, Isabella Bon, Maria Carla Re
A 30-year-old man was admitted to hospital after complaining of a retrosternal burning pain, radiating to the jugular region, and to both upper limbs. An electrocardiography examination showed a ST segment elevation involving the lower-lateral leads. A trans-thoracic ultrasonography showed findings compatible with an acute myopericarditis. All performed serological testings excluded other recent infections with cardiac tropism. Among screening tests, a peripheral lymphocyte subset analysis was performed and an inversion of the CD4/CD8 ratio was found...
June 6, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27174190/utility-of-multimodality-imaging-in-myopericarditis-with-aortitis
#19
Arman Qamar, Vikas Veeranna, Amber Fatima, Kevin M Alexander, Marcelo F Di Carli, Marc P Bonaca, Michael Steigner, Sharmila Dorbala
No abstract text is available yet for this article.
May 12, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27104014/acute-myopericarditis-caused-by-human-metapneumovirus
#20
Min Joo Choi, Joon Young Song, Tae Un Yang, Ji Ho Jeon, Ji Yun Noh, Kyung Wook Hong, Hee Jin Cheong, Woo Joo Kim
Human metapneumovirus is known to be similar to respiratory syncytial virus. Because of an incomplete protective immune response to new genotypes, re-infection occurs frequently, especially in the elderly. However, the clinical manifestations of human metapneumovirus need to be further characterized in adults. A 73-year-old woman presented to the emergency room with acute dyspnea, chest discomfort and influenza-like illness. The patient was diagnosed with human metapneumovirus infection, complicated by pneumonia and myopericarditis...
March 2016: Infection & Chemotherapy
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