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Laryngotracheal

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https://www.readbyqxmd.com/read/29767614/differential-attenuation-of-marek-s-disease-virus-induced-tumours-and-late-marek-s-disease-virus-induced-immunosuppression
#1
Nik M Faiz, Aneg L Cortes, James S Guy, Sanjay M Reddy, Isabel M Gimeno
Marek's disease virus (MDV) is a herpesvirus that induces lymphoma and a variety of non-neoplastic syndromes in chickens. Furthermore, very virulent plus (vv+) MDVs induce a form of immunosuppression (late-MDV-IS) that might involve both neoplastic and non-neoplastic mechanisms. The objective of this study was to evaluate whether the attenuation of MDV-induced tumours and late-MDV-IS occurs simultaneously or can be dissociated. The immunosuppressive ability of three viruses derived from vv+ MDV strain 686 (wild-type 686, the somewhat attenuated molecular clone 686-BAC, and the nononcogenic molecular clone lacking the two copies of the oncogene meq 686-BACΔMEQ) was evaluated...
May 16, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29764014/-comprehensive-treatment-of-335-patients-with-pyriform-sinus-carcinoma-by-surgery-via-the-paraglottic-space-approach
#2
W M Li, D M Wei, Y Qian, S D Cao, Y Xu, D Y Liu, D P Lei, X L Pan
Objective: To report the experience in comprehensive surgical treatment of pyriform sinus carcinoma via the paraglottic space approach. Methods: Three hundred and thirty-five cases with pyriform sinus carcinoma (according to UICC 2012 criteria, stage Ⅰ, 12 cases; Ⅱ, 36; Ⅲ, 79; Ⅳ, 208; T1, 26; T2, 139; T3, 121; T4, 49; cN0, 83; cN1, 61; cN2a-b, 118; cN2c, 71; cN3, 2) treated between 2006 and 2013 were retrospectively reviewed. There were 323 males and 12 females. Age aged from 36 to 80 years old with a median of 60 years old...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29743805/outcomes-after-endoscopic-dilation-of-laryngotracheal-stenosis-an-analysis-of-acs-nsqip
#3
Avni Bavishi, Emily Boss, Rahul K Shah, Jennifer Lavin
Importance: Endoscopic management of pediatric subglottic stenosis (SGS) is common, however no multi-institutional studies have assessed its perioperative outcomes. The American College of Surgeon's National Surgical Quality Improvement Program - Pediatric (ACS-NSQIP-P) represents a source of such data. Design: Current procedural terminology (CPT) codes were queried for endoscopic or open airway reconstruction in the ACS-NSQIP-P Public Use File (PUF). Demographics and 30-day events were abstracted to compare open to endoscopic techniques and to assess for risk factors for varied outcomes after endoscopic dilation...
March 2018: Journal of Clinical Outcomes Management: JCOM
https://www.readbyqxmd.com/read/29707509/idiopathic-subglottic-stenosis-techniques-and-results
#4
REVIEW
Andrea L Axtell, Douglas J Mathisen
Idiopathic subglottic stenosis is a rare condition of unknown etiology characterized by circumferential stenosis in the subglottic larynx and upper trachea. Historically, patients were treated with dilation or ablation, however this approach has proven to be largely palliative and often leads to recurrence and the need for tracheostomy. A single-staged laryngotracheal resection and reconstruction is now the preferred definitive treatment for idiopathic subglottic stenosis and can be performed with excellent patient outcomes and rare subsequent progression of the disease...
March 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29707500/functional-outcome-after-laryngo-tracheal-resection-and-reconstruction-for-acquired-benign-laryngo-tracheal-stenosis
#5
Simone T Timman, Christiana Schoemaker, Wilson W L Li, Henri A M Marres, Jimmie Honings, Wim J Morshuis, Erik H F M van der Heijden, Ad F T M Verhagen
Background: In this study we focus on functional outcomes after (laryngo)tracheal resection and reconstruction for acquired benign (laryngo)tracheal stenosis, with a specific interest in the impact of laryngeal involvement on postoperative outcome. Methods: All patients who underwent (laryngo)tracheal surgery for benign pathology between 1996 and 2017 in our centre were included in this retrospective study. Surgical outcomes were procedural success rate, and airway- and voice-related complications...
March 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29707498/management-of-laryngotracheal-trauma
#6
REVIEW
Philicia Moonsamy, Uma M Sachdeva, Christopher R Morse
Laryngotracheal trauma is a rare but potentially life-threatening injury. It is usually seen in multiple-trauma patients and can go unrecognized and undertreated due to its scarcity. The presenting symptoms often do not correlate with the severity of the injury and injuries may range from an endolaryngeal hematoma to a complete tracheal transection. Accurate diagnosis of the extent of the injury can be achieved with a combination of high resolution computed tomography, flexible fiber optic laryngoscopy and flexible bronchoscopy...
March 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29706817/the-phaces-syndrome-multiple-episodes-of-reproliferation-of-subglottic-hemangioma
#7
Randall W Holdgraf, Melissa Kress
Subglottic hemangioma is a potentially life-threatening manifestation of the PHACES syndrome. The disease process has been treated with corticosteroids, oral chemotherapeutic agents, endoscopic airway interventions, tracheostomy, and even laryngotracheal reconstruction. Oral propranolol has emerged as an effective therapy and in many cases has led to complete regression of hemangioma during the proliferative phase. There have been several reports of patients showing signs of reproliferation after discontinuing propranolol therapy...
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29664213/a-patient-centred-multi-domain-instrument-for-improving-the-clarity-of-outcomes-reporting-and-documentation-in-complex-airway-surgery
#8
S A R Nouraei, K J Heathcote
Laryngotracheal stenosis refers to abnormal narrowing of the central airways from larynx to carina. It is caused by an eclectic group of conditions that include intubation-related airway stenosis, granulomatosis with polyangiitis, tracheal compression or malignancy, and congenital laryngotracheal malformations. A significant proportion of patients with this condition can be satisfactorily treated using a combination of endoscopic and open surgical techniques and when definitive treatment is not possible, most of the remaining patients can be managed with a combination of endoscopic airway maintenance, stents, T-tubes, and/or tracheostomies...
April 17, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29627052/partial-cricotracheal-resection-and-extended-cricotracheal-resection-for-pediatric-laryngotracheal-stenosis
#9
REVIEW
Philippe Monnier
The management of pediatric laryngotracheal stenosis remains a challenging problem for the surgeon. The complexity of the various preoperative situations implies that no single treatment modality can solve the problem. This article focuses on the yield of partial cricotracheal resection and extended cricotracheal resection for the most severe grades of stenosis. Overall decannulation rates of 95% and 100% can be expected for isolated subglottic stenosis in patients with and without comorbidities but only 68% and 90% for patients with glotto-subglottic stenosis, respectively...
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29627051/contemporary-management-of-idiopathic-laryngotracheal-stenosis
#10
REVIEW
Laura Donahoe, Shaf Keshavjee
Idiopathic laryngotracheal stenosis is a rare but well-described indication for subglottic tracheal resection. Initially described by Pearson in 1975, the 1-stage subglottic tracheal resection with reconstruction of the airway ensures preservation of the recurrent laryngeal nerves while resulting in an effective and durable repair of the stenosis.
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29621756/experience-with-transcordal-silicone-stents-in-adult-laryngotracheal-stenosis-a-bicentric-retrospective-study
#11
Valerian Bourinet, Thibaut Raguin, Marc Fortin, Elsa Chetrit, Julien Guinde, Sophie Laroumagne, Nicolas Fakhry, Philippe Astoul, Christian Debry, Hervé Dutau
BACKGROUND: Benign stenosis involving laryngeal and upper tracheal structures represents a therapeutic challenge. Open surgery and endoscopic management have to be discussed by a multidisciplinary board in order to evaluate the risk and benefit for each patient. OBJECTIVE: The objective of this retrospective study was to report the experience of two French centers with transcordal silicone stents (TSS) in the endoscopic management of benign laryngotracheal stenosis (BLTS) in adults, with focus on efficacy, safety, and tolerability...
April 5, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29620463/biosecurity-assessment-and-seroprevalence-of-respiratory-diseases-in-backyard-poultry-flocks-located-close-to-and-far-from-commercial-premises
#12
T Derksen, R Lampron, R Hauck, M Pitesky, R A Gallardo
Raising backyard chickens is an ever-growing hobby in the United States. These flocks can be a substrate for respiratory disease amplification and transmission to commercial facilities. Five hundred fifty-four chickens from 41 backyard flocks were sampled in this study. ELISA kits were used to detect antibodies against avian influenza (AI), infectious laryngotracheitis (ILT), Newcastle disease (ND), infectious bronchitis (IB), Ornithobacterium rhinotracheale (ORT), Mycoplasma gallisepticum (MG), and Mycoplasma synoviae (MS)...
March 2018: Avian Diseases
https://www.readbyqxmd.com/read/29605364/management-of-complex-pediatric-laryngotracheal-stenosis-with-skin-graft-reconstruction
#13
Sarah N Bowe, Carissa J Wentland, G S Sandhu, Christopher J Hartnick
OBJECTIVES: For pediatric patients with laryngotracheal stenosis, the ultimate goal is creation of a safe, functional airway. Unfortunately, wound healing in a hollow structure can complicate repair attempts, leading to restenosis. Herein, we present our experience using skin-grafting techniques in two complex pediatric laryngotracheal stenosis cases, leading to successful decannulation or speech production. METHODS: A chart review was performed examining the evaluation and management of two pediatric patients with laryngotracheal stenosis despite prior reconstructive attempts...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29605352/open-resection-and-laryngotracheal-reconstruction-in-a-case-of-subglottic-hemangioma-in-phace-syndrome
#14
Laura A Petrauskas, Vilija J Vaitaitis, Gerhard Mundinger, Claudie Sheahan, Jeffrey Poole, Sohit Paul Kanotra
We describe a 1 month old infant with PHACE syndrome who underwent successful management of subglottic hemangioma by open resection and laryngotracheal reconstruction using a thyroid ala graft. Propranolol is typically the treatment of choice for subglottic hemangiomas however, recent reports have suggested adverse complications with the use of propranolol in children with PHACE syndrome. The child had cerebral and cervical vascular anomalies associated with her PHACE syndrome making her at an increased risk of stroke with the use of propranolol...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29605348/systematic-review-meta-analysis-comparing-successful-outcomes-after-single-vs-double-stage-laryngotracheal-reconstruction
#15
REVIEW
Reema Padia, Phayvanh Sjogren, Marshall Smith, Harlan Muntz, Gregory Stoddard, Jeremy Meier
OBJECTIVE: To compare operation-specific decannulation rates between single-stage (SSLTR) and double-stage laryngotracheal reconstruction (DSLTR) when controlling for grade of airway stenosis. METHODS: A systematic review and meta-analysis were performed using PubMed, EMBASE and Cochrane databases from 1970 to 2015 to examine primary SSLTR and DSLTR for subglottic stenosis in patients 18 years or younger. Primary outcome was decannulation or extubation after LTR...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29582748/airway-management-changes-associated-with-rising-radiologic-incidence-of-external-laryngotracheal-injury
#16
Derrick R Randall, Luke Rudmik, Chad G Ball, J Douglas Bosch
BACKGROUND: Traumatic laryngeal injuries are uncommon life-threatening injuries that require prompt, rational management of a potentially precarious airway. It is unclear whether the current incidence of laryngotracheal injury is due to enhanced injury detection or increased occurrence. The objective of this study was to evaluate the relations between diagnostic imaging with both initial airway management and surgical treatment in patients with external laryngotracheal injuries (ELTIs) in Alberta...
April 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29580592/benchmarking-the-applicability-of-four-methods-of-endotracheal-tube-cuff-inflation-for-optimal-sealing-a-randomized-trial
#17
Georgia G Tsaousi, Chryssa Pourzitaki, Dimitra Chlorou, Konstantinos Papapostolou, Dimitrios G Vasilakos
PURPOSE: To assess the comparable applicability of four methods of endotracheal tube cuff (ETTc) inflation on the basis of optimal level of intracuff pressure and presence of intubation-related complications. DESIGN: Double-blind, randomized trial. METHODS: A total of 139 adult surgical patients scheduled to undergo nitrous oxide-free general anesthesia were assigned into one of four groups according to the method used for ETTc inflation. The cuff pressure and air volume applied in each method, and laryngotracheal complications were recorded...
April 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29580173/reinforced-electrospun-polycaprolactone-nanofibers-for-tracheal-repair-in-an-in-vivo-ovine-model
#18
Jakob M Townsend, Lindsey M Ott, Jean R Salash, Kar-Ming Fung, Jeremiah T Easley, Howard B Seim, Jed Johnson, Robert A Weatherly, Michael Scott Detamore
Tracheal stenosis caused by congenital anomalies, tumors, trauma, or intubation-related damage can cause severe breathing issues, diminishing the quality of life, and potentially becoming fatal. Current treatment methods include laryngotracheal reconstruction or slide tracheoplasty. Laryngotracheal reconstruction utilizes rib cartilage harvested from the patient, requiring a second surgical site. Slide tracheoplasty involves a complex surgical procedure to splay open the trachea and reconnect both segments to widen the lumen...
March 27, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29519822/full-genome-sequence-of-infectious-laryngotracheitis-virus-gallid-alphaherpesvirus-1-strain-vfar-043-isolated-in-peru
#19
Sandra Morales Ruiz, Jorge Bendezu Eguis, Ricardo Montesinos, Luis Tataje-Lavanda, Manolo Fernández-Díaz
We report here the first genome sequence of infectious laryngotracheitis virus isolated in Peru from tracheal tissues of layer chickens. The genome showed 99.98% identity to the J2 strain genome sequence. Single nucleotide polymorphisms were detected in five gene-coding sequences related to vaccine development, virus attachment, and viral immune evasion.
March 8, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29513871/correlation-between-bulbar-functionality-and-laryngeal-penetration-and-or-laryngotracheal-aspiration-on-motor-neuron-disease
#20
Bárbara Carolina Brandão, Alline de Sousa Galdino, Luciano Garcia Lourenção, Glaucia Santana Trindade, Magali Aparecida Orate Menezes da Silva, Roberta Gonçalves da Silva
OBJECTIVE: Describe and correlate bulbar functionality with laryngeal penetration and/or laryngotracheal aspiration for different food consistencies in Motor Neuron Disease (MND). METHODS: Study participants were 18 individuals diagnosed with MND regardless of the type and time of onset of disease. The Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised/BR (ALSFRS-R/BR) was applied, and only the bulbar parameter, which includes speech, salivation and swallowing, was analyzed, with scores raging from 0 (disability) to 12 (normal functionality)...
March 5, 2018: CoDAS
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