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premature ejaculation

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https://www.readbyqxmd.com/read/29453817/endocrine-and-psychological-aspects-of-sexual-dysfunction-in-klinefelter-patients
#1
A Ferlin, R Selice, S Angelini, M Di Grazia, N Caretta, F Cavalieri, A Di Mambro, C Foresta
Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29432875/title-of-the-manuscript-new-tools-to-measure-ejaculatory-latency-arousal-to-ejaculation-time-interval-aeti-and-erection-to-ejaculation-time-interval-eeti-a-pilot-study
#2
Gajanan S Bhat, S Anuradha
OBJECTIVE: To evaluate the proposed novel tools, namely, Arousal to Ejaculation Time Interval (AETI) and Erection to Ejaculation Time Interval (EETI), to measure ejaculatory latency during different types of sexual encounters, in a pilot study. METHODS: The study period was from September 2016 to December 2016. After obtaining informed consent and institutional review board approval, the medical practitioners without any co-morbidity, who volunteered to participate, were asked to report the self assessed time taken to ejaculate following sexual arousal (AETI) and also following a sustained erection (EETI) during a sexual activity...
February 9, 2018: Urology
https://www.readbyqxmd.com/read/29430157/pregnancy-outcome-of-home-intravaginal-insemination-in-couples-with-unconsummated-marriage
#3
Kaberi Banerjee, Bhavana Singla
Unconsummated marriage are mainly due to vaginismus or erectile dysfunction. They contribute to about 5% of couples in an infertility clinic. Their incidence is increasing in the metropolitan cities because of stressful lifestyles. Many of couples are advised intrauterine insemination as fertility treatment. However, home insemination is a simple, inexpensive and effective way of achieving pregnancy in such couples. We present the first study to document pregnancy rates of artificial home intravaginal insemination in couples with unconsummated marriage...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29405168/penile-sensory-thresholds-in-subtypes-of-premature-ejaculation-implications-of-comorbid-erectile-dysfunction
#4
Xiang Chen, Fei-Xiang Wang, Chao Hu, Nian-Qin Yang, Ji-Can Dai
Penile hypersensitivity plays an important role in premature ejaculation (PE), but differences in penile sensitivity among subtypes of PE are unknown. Therefore, we compared penile sensory thresholds in PE subtypes of lifelong and acquired PE, PE with and without erectile dysfunction (ED), PE with an intravaginal ejaculation latency time ≤1 min and >1 min, and PE with and without orgasmic pleasure perceptual dysfunction. During August 2014 to January 2016, 136 patients with PE were included. Penile warm, cold, and vibratory thresholds were measured...
February 6, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29370617/re-validity-of-premature-ejaculation-diagnostic-tool-and-its-association-with-international-index-of-erectile-function-15-in-chinese-men-with-evidence-based-defined-premature-ejaculation
#5
https://www.readbyqxmd.com/read/29369372/effects-of-the-dopamine-d3-receptor-agonist-7-hydroxy-2-di-n-propylamino-tetralin-in-hyperthyroidism-induced-premature-ejaculation-rat-model
#6
O Cinar, N Durmus, G Aslan, O Demir, A S Evcim, S Gidener, A A Esen
Various factors are involved in the aetiology of premature ejaculation (PE). Hyperthyroidism is one of the causes of acquired PE, but the exact mechanism by which it causes the disorder is not yet understood. The aim of this study was to evaluate the role of the dopaminergic system in hyperthyroidism-induced PE by the intracerebroventricular microinjection of the preferentially active dopamine receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in a rat model of this disorder. Wistar rats were randomly divided into hyperthyroid and control groups, and ejaculation was induced by the ICV administration of 7-OH-DPAT...
January 25, 2018: Andrologia
https://www.readbyqxmd.com/read/29338524/visceral-adiposity-index-is-associated-with-premature-ejaculation-inversely-a-cross-sectional-study
#7
Suleyman Sami Cakir, Levent Ozcan, Huseyin Besiroglu, Murat Dursun, Emre Can Polat, Alper Otunctemur, Emin Ozbek
OBJECTIVE: Visceral adiposity index (VAI) is a novel indicator for the assessment of visceral obesity. In this study, we aimed to evaluate the relationship between VAI and premature ejaculation (PE). MATERIALS AND METHOD: A total of 300 men were included in the study. Hundred and fifty men with PE and 150 men without PE (control). All men were evaluated for PE by premature ejaculation diagnostic tool (PEDT). VAI levels were calculated using body mass index (BMI), high density lipoprotein and triglyceride (TG) levels...
January 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29325456/dual-purpose-vardenafil-hydrochloride-dapoxetine-hydrochloride-orodispersible-tablets-in-vitro-formulation-evaluation-stability-study-and-in-vivo-comparative-pharmacokinetic-study-in-healthy-human-subjects
#8
Khaled El-Refaie, Mahmoud H Teaima, Mohamed A El-Nabarawi
Erectile Dysfunction (ED) is the most important disorder after premature ejaculation for sexual activity in men. Vardenafil Hydrochloride (VH) is an oral therapy for the treatment of erectile dysfunction. VH oral disintegrating tablets (ODTs) have been prepared by freeze drying technique to improve its dissolution profile and the overall clinical performance. Dapoxetine Hydrochloride (DH) was added to the best three formulae of the prepared VH ODTs to treat premature ejaculation. All the ODTs formulae were evaluated for weight variation, friability, drug content, in-vitro disintegration time, wetting time, and the dissolution study...
January 11, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29307732/promescent%C3%A2-has-a-cytotoxic-impact-on-fresh-human-sperm-in-vitro
#9
Melissa Sutton, Caitlin Hunn, Roxanne B Summers-Colquitt, Shu-Hung Chen, Shahryar K Kavoussi, Keikhosrow M Kavoussi, Parviz K Kavoussi
OBJECTIVES: To assess the impact of Promescent®, a commonly used topical medication for premature ejaculation (PE), on human sperm motility, forward progression (FP), viability, and sperm DNA fragmentation (SDF) in vitro. METHODS: Aliquots from specimens for diagnostic semen analyses from patients (n=20) presenting to a couple's fertility center andrology laboratory for fertility testing were included after the full diagnostic semen analyses were performed. Samples which met the World Health Organization (WHO) 5th edition criteria as "normal" had Promescent® applied to an aliquot of the sample and motility, FP, viability, and SDF were compared to an aliquot which was not treated with Promescent®...
January 4, 2018: Urology
https://www.readbyqxmd.com/read/29259775/premature-ejaculation-challenging-new-and-the-old-concepts
#10
REVIEW
Odunayo Kalejaiye, Khaled Almekaty, Gideon Blecher, Suks Minhas
Premature ejaculation remains a difficult condition to manage for patients, their partners, and the clinician. Whilst prevalence rates are estimated to be 20-40%, determining a diagnosis of premature ejaculation is difficult, as the definition remains both subjective and ill-defined in the clinical context. As our understanding of the ejaculatory pathway has improved, new opportunities to treat the condition have evolved with mixed results. In this review, we explore some of these controversies surrounding the aetiology, diagnosis, and treatment of this condition and discuss potential novel therapeutic options...
2017: F1000Research
https://www.readbyqxmd.com/read/29203842/tolerability-and-adequate-therapeutic-dosage-of-oral-clomipramine-for-the-treatment-of-premature-ejaculation-a-randomized-double-blind-placebo-controlled-fixed-dose-parallel-grouped-clinical-study
#11
Sae Woong Kim, Jin Bong Choi, Su Jin Kim, Kyung Soo Kim, Churl Min Kim, Dong Hyeon Lee, Whan Seok Choi
To evaluate the adequate therapeutic dosage of clomipramine 15 mg/day and clomipramine 30 mg/day in male patients with premature ejaculation (PE), this study enrolled men aged 20-65 years who met diagnostic criteria for PE including Intravaginal Ejaculation Latency Time (IELT) less than 2 min for at least 75% of their sexual intercourses. Subjects received placebo, clomipramine 15 mg, or clomipramine 30 mg prn (2~6 h before intercourse) for 4 weeks. Efficacy was assessed using fold change, percentile change, and mean change of IELT, as well as Drug Coitus Interval Time (DCIT)...
December 4, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29198511/preliminary-evidence-for-an-association-between-variants-of-the-catechol-o-methyltransferase-comt-gene-and-premature-ejaculation
#12
Patrick Jern, Ada Johansson, Jana Strohmaier, Jens Treutlein, Juhana Piha, Marcella Rietschel
BACKGROUND: Studies have suggested that dopamine plays a role in the neurobiological mechanism that triggers ejaculation, leading scientists to hypothesize that dopamine-related genetic polymorphisms could contribute to symptoms of premature ejaculation (PE). AIM: To investigate associations between dopamine receptor and catechol-O-methyltransferase (COMT; an enzyme involved in the catabolism of dopamine) gene-linked polymorphisms and PE. METHODS: PE status in patient groups was determined by clinical diagnosis performed by a physician specializing in sexual medicine...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29161211/sexual-cognitions-trait-anxiety-sexual-anxiety-and-distress-in-men-with-different-subtypes-of-premature-ejaculation-and-in-their-partners
#13
Philippe Kempeneers, Robert Andrianne, Marion Cuddy, Sylvie Blairy
This study examined trait anxiety and sexual cognitions in 610 men with premature ejaculation (PE) (DSM-IV-TR criteria) and in 107 partners of these men, and compared their scores to normative data. Sexual anxiety, intra-vaginal ejaculatory latency time, feeling of control over ejaculation, and PE-related distress were also assessed. The scores of 343 participants (56.23%) with clearly identifiable subtypes of PE according to Waldinger's classification system (lifelong, acquired, variable and subjective subtypes) were compared in these domains...
November 21, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29150283/transcutaneous-neuromuscular-electrical-stimulation-may-be-beneficial-in-the-treatment-of-premature-ejaculation
#14
Ilan Gruenwald, Ege Can Serefoglu, Tal Gollan, Shmuel Springer, Gideon Meiry, Boaz Appel, Arik Shechter
Approximately 20-30% of sexually active men suffer from Premature Ejaculation (PE), but the pathophysiology still remains unclear and the current available treatments for PE are unsatisfying. Considering the role of rhythmic bulbospongiosus and ischiocavernosus Muscles contractions on the ejaculatory reflex, we hypothesize that weakening this muscles via inhibiting it's contractions by Application of Neuromuscular Electrical Stimulation prior to the planned sexual activity, may have a beneficial effect in the treatment of PE...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29144913/re-silodosin-versus-naftopidil-in-the-treatment-of-premature-ejaculation-a%C3%A2-prospective-multicenter-trial
#15
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29135153/-the-evidence-for-the-efficiency-and-safety-of-dapoxetine-in-treating-premature-ejaculation
#16
N D Akhvlediani, I P Matyukhov
The aim of the study is to assess the evidence on the efficacy and safety of dapoxetine in premature ejaculation (PE). The analysis includes results of randomized placebo-controlled trials, integrative reviews and one meta-analysis on the clinical efficacy and safety of dapoxetine. All studies have shown higher efficacy of dapoxetine in patients with PE compared with placebo. Its administration at a dosage of 30 and 60 mg results in an increase in the coitus duration up to approximately 3 and 3.5 minutes, respectively...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29124247/chlamydia-trachomatis-versus-common-uropathogens-as-a-cause-of-chronic-bacterial-prostatitis-is-there-any-difference-results-of-a-prospective-parallel-cohort-study
#17
Tommaso Cai, Francesca Pisano, Gabriella Nesi, Vittorio Magri, Paolo Verze, Gianpaolo Perletti, Paolo Gontero, Vincenzo Mirone, Riccardo Bartoletti
Purpose: The role of Chlamydia trachomatis (CT) infection in chronic bacterial prostatitis (CBP) is well known. What is unclear is whether there are any differences in the course or clinical outcome of the disease when the cause is CT or other uropathogens. Materials and Methods: A series of 311 patients affected by CBP due to CT (cohort A) was compared with a group of 524 patients affected by CBP caused by common uropathogen bacteria (cohort B). All participants completed the following questionnaires: National Institutes of Health Chronic Prostatitis Symptom Index, International Prostate Symptom Score, International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD), Premature Ejaculation Diagnostic Tool (PEDT), and the Short Form 36 (SF-36) Health Survey...
November 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29104138/serotonergic-polymorphisms-in-the-control-of-ejaculation
#18
REVIEW
Patrick Jern, Daniel Ventus
Serotonin has long been implicated in the regulation of the processes that trigger the ejaculatory reflex. Most evidence of serotonergic involvement is, however, indirect, stemming either from studies on rodents or clinical trials investigating effects of serotonergic drugs. In the past decade, emerging evidence for heritability (i.e., genetic effects) of premature ejaculation (PE) symptoms has spawned a number of scholarly attempts to identify genes that regulate ejaculation, most of which have focused on candidate genes related to the serotonergic system...
November 2, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29102483/the-digital-environment-in-men-s-sexual-disorders-a-systematic-review
#19
E García-Cruz, J Romero-Otero, M Fode, A Alcaraz
CONTEXT: The revolution of digital technologies constitutes a new setting for the patient-physician relationship and provides patients with a scenario of privacy and universal access to a vast amount of information. However, there is little information on how digital resources are used and what their advantages and disadvantages are. OBJECTIVES: To explore the scope of the scientific research on the use of digital technology related to men's sexual disorders and to analyze the primary sources of digital information related to this field...
November 1, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29071143/the-prevalence-of-an-excessive-prepuce-and-the-effects-of-distal-circumcision-on-premature-ejaculation
#20
Luigi Gallo
OBJECTIVE: To investigate the prevalence of an excessive prepuce in patients with premature ejaculation (PE) and to evaluate the effectiveness of distal circumcision in reducing the penile hypersensitivity, which is thought to be a cause of PE. PATIENTS AND METHODS: Men were considered to have an excessive prepuce if the foreskin exceeded the external urethral meatus by ≥1 cm in the flaccid state. The diagnosis of PE was based on the Premature Ejaculation Diagnostic Tool (PEDT) questionnaire score and on the intravaginal ejaculatory latency time (IELT)...
June 2017: Arab Journal of Urology
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