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premature ejaculation

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https://www.readbyqxmd.com/read/27908635/from-the-definition-to-the-social-impact-of-premature-ejaculation-expert-consensus
#1
EDITORIAL
N Cruz-Navarro, R Prieto-Castro, F Cabello-Santamaría, F García-José, A Fernández-Lozano, M Larrazábal-Murillo, A Martín-Morales, F Sánchez-Sánchez, C San Martín-Blanco, J Viladoms-Fuster
No abstract text is available yet for this article.
November 28, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27890601/tramadol-effects-on-sexual-behavior-in-male-rats-are-mainly-caused-by-its-5-ht-reuptake-blocking-effects
#2
Jocelien D A Olivier, Diana C Esquivel Franco, Ronald Oosting, Marcel Waldinger, Zoltan Sarnyai, Berend Olivier
Tramadol is a well-known and effective analgesic. Recently it was shown that tramadol is also effective in human premature ejaculation. The inhibitory effect of tramadol on the ejaculation latency is probably due to its mechanism of action as a μ-opioid receptor agonist and noradrenaline/serotonin (5-HT) reuptake inhibitor. In order to test this speculation, we tested several doses of tramadol in a rat model of male sexual behavior and investigated two types of drugs interfering with the μ-opioid and the 5-HT system...
November 24, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27871957/tramadol-abuse-and-sexual-function
#3
REVIEW
Ibrahim A Abdel-Hamid, Karl-Erik Andersson, Marcel D Waldinger, Tarek H Anis
INTRODUCTION: Tramadol exhibits an effect profile similar to that of opioid agonists, and tramadol abuse seems to be a problem for a number of countries. The relationship between tramadol and sexual function appears to be controversial. Men with premature ejaculation (PE) may benefit from taking tramadol off label; however, these patients live "on a knife's edge" and are exquisitely sensitive to develop other sexual dysfunctions. AIM: To review the literature regarding the problem of tramadol abuse and its relationship with sexual function...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27860425/centrally-mediated-ejaculatory-response-via-sympathetic-outflow-in-rats-role-of-n-methyl-d-aspartic-acid-receptors-in-paraventricular-nucleus
#4
J-D Xia, J Chen, H-J Sun, L-H Zhou, G-Q Zhu, Y Chen, Y-T Dai
Ejaculation is mediated by a spinal generator, which integrates inputs related to the sexual activity and coordinates sympathetic, parasympathetic, and motor outflow. Previous clinical studies indicate that primary premature ejaculation is related to the hyperactivity of the sympathetic nervous system. In this study, we explored the roles of N-methyl-D-aspartic acid (NMDA) receptors in paraventricular nucleus of the hypothalamus (PVN) on ejaculatory responses and its potential mechanism in the rats. We found that microinjection of 0...
November 16, 2016: Andrology
https://www.readbyqxmd.com/read/27803891/a-qualitative-study-of-the-relationship-between-methamphetamine-abuse-and-sexual-dysfunction-in-male-substance-abusers
#5
Behrouz Dolatshahi, Ali Farhoudian, Mozhgan Falahatdoost, Mahmoud Tavakoli, Ebrahim Rezaie Dogahe
BACKGROUND: Increased prevalent use of methamphetamine is a global public challenge. Information on drug use can be helpful in preventing high-risk behavior related to drug abuse. OBJECTIVES: This study aims to investigate the sexual function changes related to methamphetamine use in the male clients of public and private addiction treatment centers. PATIENTS AND METHODS: In this qualitative study, 45 men (35 methamphetamine users, 5 family members of the users, and 5 psychiatrists or physicians who were famous for treating or researching addiction) are involved...
September 2016: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/27790295/psychological-and-sexual-effects-of-circumcision-in-adult-males
#6
Yasin Aydogmus, Murat Semiz, Okan Er, Okan Bas, Irfan Atay, Muhammet Fatih Kilinc
INTRODUCTION: Our aim was to investigate the psychological and sexual effects of circumcision in adult men, and analyze these changes following circumcision. METHODS: We included 37 adults who applied to our clinic for circumcision and who did not have any psychiatric or urologic disorders and age-matched 30 controls in our study. Body Cathexis Scale (BCS), Liebowitz Social Anxiety Scale (LSAS), and Premature Ejaculation Diagnostic Tool (PEDT) were applied to the study group twice, once before and once three months after circumcision, and only once in the control group...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27784887/ejaculatory-training-lengthens-the-ejaculation-latency-and-facilitates-the-functioning-of-the-spinal-generator-for-ejaculation-of-rats-with-rapid-ejaculation
#7
M de L Rodríguez-Peña, G Rodríguez-Manzo, M Carro-Juárez
A spinal pattern generator controls the ejaculatory response. Central pattern generators (CPGs) may be entrained to improve the motor patterns under their control. In the present study we tested the hypothesis that training of the spinal generator for ejaculation (SGE) by daily copulation until ejaculation, could promote substantive changes in its functioning permitting a better SGE control of the genital motor pattern of ejaculation (GMPE) and, as a consequence, a normalization of the ejaculation latency of rats with rapid ejaculation...
October 27, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27733531/semen-quality-impairment-is-associated-with-sexual-dysfunction-according-to-its-severity
#8
F Lotti, G Corona, G Castellini, E Maseroli, M G Fino, M Cozzolino, M Maggi
STUDY QUESTION: Is sexual dysfunction associated with severity of semen quality impairment in men with couple infertility? SUMMARY ANSWER: In males of infertile couples the prevalence of erectile dysfunction (ED) increases as a function of semen quality impairment severity. WHAT IS KNOWN ALREADY: Infertile men are at a higher risk for sexual dysfunction, psychopathological and general health disorders. However, it has never been systematically investigated if these problems are associated with severity of semen quality impairment...
October 12, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27729995/effectiveness-of-on-demand-silodosin-in-the-treatment-of-premature-ejaculation-in-patients-dissatisfied-with-dapoxetine-a-randomized-control-study
#9
Gajanan S Bhat, Anuradha Shastry
INTRODUCTION: Premature ejaculation is a common sexual disorder, which is usually underreported. Multiple treatment methodologies are in use due to the absence of an effective, universally acceptable treatment modality. The most common drug used is dapoxetine, which has adverse effects limiting its long-term use. Hence, we decided to evaluate the effectiveness of 'on demand' silidosin 4 mg in patients with premature ejaculation, who were dissatisfied with dapoxetine 30 mg. MATERIAL AND METHODS: The study included 64 patients who reported premature ejaculation who were unhappy with the treatment with 'on demand' dapoxetine 30 mg, either due to its adverse effects or because of its overall inefficacy...
2016: Central European Journal of Urology
https://www.readbyqxmd.com/read/27713390/association-of-stin2-vntr-polymorphism-of-serotonin-transporter-gene-with-lifelong-premature-ejaculation-a-case-control-study-in-han-chinese-subjects
#10
Yuanyuan Huang, Xiansheng Zhang, Jingjing Gao, Dongdong Tang, Pan Gao, Dangwei Peng, Chaozhao Liang
BACKGROUND The STin2 VNTR polymorphism has a variable number of tandem repeats in intron 2 of the serotonin transporter gene. We aimed to explore the relationship between STin2 VNTR polymorphism and lifelong premature ejaculation (LPE). MATERIAL AND METHODS We recruited a total of 115 outpatients who complained of ejaculating prematurely and who were diagnosed as LPE, and 101 controls without PE complaint. Allelic variations of STin2 VNTR were genotyped using PCR-based technology. We evaluated the associations between STin2 VNTR allelic and genotypic frequencies and LPE, as well as the intravaginal ejaculation latency time (IELT) of different STin2 VNTR genotypes among LPE patients...
October 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27711091/testicular-prosthesis-patient-satisfaction-and-sexual-dysfunctions-in-testis-cancer-survivors
#11
Francesco Catanzariti, Benedetta Polito, Massimo Polito
PURPOSE: We studied patient satisfaction about sexual activity after prosthesis implantation using validated questionnaires with the aim to discover if testicular prosthesis could be responsible of sexual dysfunctions (erectile dysfunction or premature ejaculation). MATERIALS AND METHODS: We evaluated a total of 67 men who underwent radical orchiectomy for testicular cancer and a silicon testicular prosthesis implantation from January 2008 to June 2014 at our Hospital...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27711088/a-combination-of-tryptophan-satureja-montana-tribulus-terrestris-phyllanthus-emblica-extracts-is-able-to-improve-sexual-quality-of-life-in-patient-with-premature-ejaculation
#12
Salvatore Sansalone, Giorgio Ivan Russo, Nicola Mondaini, Francesco Cantiello, Gabriele Antonini, Tommaso Cai
OBJECTIVE: The management of patient affected by premature ejaculation (PE) is nowadays not highly satisfactory. Here, we aimed to evaluate the tolerability and efficacy of a combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts in order to improve sexual quality of life in patients with premature ejaculation. MATERIALS AND METHODS: All patients attending to 5 urological centers from January 2015 to March 2015, due to premature ejaculation were enrolled in this study...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27704632/current-and-emerging-therapies-in-premature-ejaculation-where-we-are-coming-from-where-we-are-going
#13
Christopher Martin, Hunter Nolen, Jason Podolnick, Run Wang
Premature ejaculation is the most common form of sexual dysfunction among men. The pathophysiology of premature ejaculation appears to be multifactorial, implicating the need for multimodal therapeutic regimens to successfully treat premature ejaculation. Multiple treatment regimens have been shown to be effective in extending the time between penetration and ejaculation. These treatment modalities include everything from behavioral modifications and medications to diet alterations and major surgery. The goal of the present article was to review the commonly used treatment regimens used in the treatment of premature ejaculation, as well as to introduce and discuss the newest treatment routines under study for the treatment of premature ejaculation...
October 5, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27698696/rhodiola-rosea-folic-acid-zinc-and-biotin-endep-%C3%A2-is-able-to-improve-ejaculatory-control-in-patients-affected-by-lifelong-premature-ejaculation-results-from-a-phase-i-ii-study
#14
Tommaso Cai, Paolo Verze, Paolo Massenio, Daniele Tiscione, Gianni Malossini, Luigi Cormio, Giuseppe Carrieri, Vincenzo Mirone
The therapeutic armamentarium currently available for the treatment of premature ejaculation (PE) is not highly satisfactory. However, phytotherapeutics appear to be an interesting option for PE management. The present study aimed to evaluate the tolerability and efficacy of a phytotherapeutic combination of Rhodiola rosea, folic acid, biotin and zinc (EndEP(®)) in the treatment of patients affected by lifelong PE. All patients affected by lifelong PE who were attending three Urological Institutions from July to December 2014 were enrolled in this prospective, multicentre, phase I-II study...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27681841/relation-between-blood-vitamin-b12-levels-with-premature-ejaculation-case-control-study
#15
M Kadihasanoglu, M Kilciler, G Kilciler, U Yucetas, E Erkan, E Karabay, M G Toktas, M Kendirci
The aim of this study was to investigate whether vitamin B12 levels are associated with premature ejaculation (PE). A total of 109 subjects (56 PE and 53 controls) were included in this study. PE was defined as self-reported intravaginal ejaculatory latency time (IELT) based on the Diagnostic and Statistical Manual of Mental Disorders IV criteria and those who had had an IELT of <2 min was considered as PE. All participants were evaluated using premature ejaculation diagnostic tool (PEDT), International Index of Erectile Function (IIEF) and Beck Depression Inventory (BDI)...
September 29, 2016: Andrologia
https://www.readbyqxmd.com/read/27679962/effects-of-paroxetine-on-intravaginal-ejaculatory-latency-time-in-egyptian-patients-with-lifelong-premature-ejaculation-as-a-function-of-serotonin-transporter-polymorphism
#16
A M Salem, I I Kamel, L A Rashed, S F GamalEl Din
Premature ejaculation (PE) is a common ejaculatory complaint. The estimated rates among Turkish men reached 20%, although the severest type of PE (lifelong PE) usually does not exceed 2.3%. This could be seen in line with two survey studies involving five nations. They revealed that 2.5% of men had an intravaginal ejaculation latency time of <1 min and 6% of <2 min. Rapid ejaculation may be treated pharmacologically with a variety of different medications that act either centrally or locally to delay ejaculation and subsequent orgasm...
September 29, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27676982/sexual-disorders-in-stroke-patients-compared-with-control-subjects-in-benin-a-prospective-study
#17
Herman Azanmasso, Étienne Alagnidé, Joycia G Hounmenou, Didier Niama Natta, Toussaint G Kpadonou
OBJECTIVE: The genito-sexual disorders can be caused by stroke. These disorders often are silent even if they are at the heart of patient concerns. The objective was to study the sexual dysfunction in patients with stroke compared to control subjects. MATERIAL/PATIENTS AND METHODS: We did a prospective descriptive analytical cross-sectional study in the department of functional rehabilitation of National university hospital center of Cotonou CNHU HKM. This study involved 134 subjects including 67 stroke patients dating back at least 6 months and 67 controls matched to cases by age and sex...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27659917/sexual-dysfunction-in-klinefelter-s-syndrome-patients
#18
H El Bardisi, A Majzoub, S Al Said, H Alnawasra, Z Dabbous, M Arafa
Klinefelter's syndrome (KS) is the most common chromosomal abnormality in men with infertility and hypogonadism. Although its influence on fertility has been extensively investigated, very few studies assessed the sexual function of patients with KS. Our aim was to assess the prevalence of sexual dysfunction in patients with KS and investigate possible aetiological factors for reported findings. Medical records of 53 patients with KS were retrospectively reviewed and compared to 75 age-matched control subjects who were prospectively recruited...
September 23, 2016: Andrologia
https://www.readbyqxmd.com/read/27652232/surgery-is-not-indicated-for-the-treatment-of-premature-ejaculation
#19
James Anaissie, Faysal A Yafi, Wayne J G Hellstrom
Premature ejaculation (PE) is considered the most common male sexual disorder, affecting up to 75% of men at some point in their lives. While medical management is the mainstay of therapy, surgical options such as dorsal nerve neurectomy (DNN), hyaluronic acid (HA) gel glans penis augmentation, and circumcision have been studied as alternative forms of treatment. Preliminary studies have suggested that DNN and HA gel glans penis augmentation are relatively safe and effective, but due to a lack of large, multicenter, randomized-control trials with long-term follow-up, the International Society of Sexual Medicine (ISSM) has been unable to endorse DNN or HA gel glans penis augmentation as options in the treatment of PE...
August 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27652230/retrograde-ejaculation-painful-ejaculation-and-hematospermia
#20
REVIEW
Arie Parnham, Ege Can Serefoglu
Although there has been an increased interest on premature ejaculation in the recent years, our understanding regarding the disorders of retrograde ejaculation, painful ejaculation and hematospermia remain limited. All three of these conditions require a keen clinical acumen and willingness to engage in thinking outside of the standard established treatment paradigm. The development of novel investigational techniques and treatments has led to progress in the management of these conditions symptoms; however, the literature almost uniformly is limited to small series and rare randomised trials...
August 2016: Translational Andrology and Urology
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