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premature ejaculation

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https://www.readbyqxmd.com/read/28331291/pharmacokinetics-and-tolerability-of-da-8031-a-novel-selective-serotonin-reuptake-inhibitor-for-premature-ejaculation-in-healthy-male-subjects
#1
Dongseong Shin, SeungHwan Lee, Sojeong Yi, Seo Hyun Yoon, Joo-Youn Cho, Mi Young Bahng, In-Jin Jang, Kyung-Sang Yu
OBJECTIVE: DA-8031 is a selective serotonin reuptake inhibitor under development for the treatment of premature ejaculation. This is the first-in-human study aimed at evaluating the pharmacokinetics and tolerability of DA-8031 and its metabolites (M1, M2, M4, and M5) in the plasma and urine after administration of a single oral dose in healthy male subjects. METHODS: A dose block-randomized, double-blind, placebo-controlled, single ascending dose study was conducted...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28261848/impact-of-physical-activity-on-patient-self-reported-outcomes-of-lifelong-premature-ejaculation-patients-results-of-a-prospective-randomised-sham-controlled-trial
#2
M F Kilinc, Y Aydogmus, Y Yildiz, O G Doluoglu
Previous studies have investigated whether physical activity increases serotonin hormone levels. Serotonin receptor dysfunction is one of the frequently accused factors of premature ejaculation (PE). Nevertheless, no studies up to date have demonstrated that the association between physical activity and premature ejaculation. We aimed to investigate the relationship between physical activity and PE and determine whether moderate physical activity might delay ejaculation time or be an alternative treatment for PE...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28248021/-new-data-on-the-effectiveness-of-tadalafil-alone-and-in-combination-with-neyrodoz-in-treating-erectile-dysfunction-associated-with-secondary-premature-ejaculation
#3
N D Akhvlediani, I P Matyukhov
AIM: To compare the effectiveness of the phosphodiesterase type 5 inhibitor (PDE-5i) tadalafil alone and in combination with a biologically active dietary supplement (BADS) NeyroDoz, containing the precursors of serotonin in patients with erectile dysfunction (ED) associated with secondary premature ejaculation (SPE). MATERIAL AND METHODS: 105 patients (mean age 36.2+/-9.1 years) with concomitant ED and SPE were included in a prospective study and divided into 2 groups...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28217932/the-relationship-between-the-second-to-fourth-digit-ratios-and-lifelong-premature-ejaculation-a-prospective-comparative-study
#4
D Bolat, G U Kocabas, T Kose, T Degirmenci, M E Aydin, C Dincel
To investigate the relationship between the fetal androgen exposure and lifelong premature ejaculation by using the ratio of the second (index)-to-fourth (ring) digits (2D : 4D) which is the marker for higher prenatal androgen exposure. Totally 65 patients with lifelong premature ejaculation and 65 control cases without any ejaculatory complaints were enrolled in the study. A detailed medical history was obtained and self-estimated intravaginal ejaculatory latency times were recorded. Ejaculation function was evaluated by Premature Ejaculation Diagnostic Tool...
February 19, 2017: Andrology
https://www.readbyqxmd.com/read/28215172/the-phosphodiesterase-5-inhibitors-pde-5i-for-erectile-dysfunction-ed-a-therapeutic-challenge-for-psychiatrists
#5
Chong Siew Koon, Hatta Sidi, Jaya Kumar, Srijit Das, Ong Wan Xi, Muhammad Hizri Hatta, Cesar Alfonso
Erectile function (EF) is a prerequisite for satisfactory sexual intercourse (SI) and central to male sexual functioning. Satisfactory SI eventually leads to orgasm - a biopsychophysiological state of euphoria - leading to a sense of bliss, enjoyment and positive mental well being. For a psychiatrist, treating ED is self-propelled to harmonize these pleasurable experiences alongside with encouragement of physical wellness and sensuality. Hence, the role of PDE-5i is pivotal in the context of treating ED constitutes a therapeutic challenge...
February 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28179637/the-relationship-between-acquired-premature-ejaculation-and-metabolic-syndrome-a-prospective-comparative-study
#6
D Bolat, G U Kocabas, B Gunlusoy, O Aydogdu, M E Aydin
The aim of this study was to investigate the relationship between metabolic syndrome (MetS) and acquired premature ejaculation (PE). A total of 100 patients with acquired PE and 100 control cases were enrolled in the study. After obtaining a detailed medical history, anthropometric (weight, height and waist circumference) and blood pressure measurements were performed. Ejaculation and erection functions were evaluated by Premature Ejaculation Diagnostic Tool (PEDT) and International Index of Erectile Function-5 (IIEF-5), respectively...
February 9, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28147446/response-to-re-resiniferatoxin-for-treatment-of-lifelong-premature-ejaculation-a-preliminary-study
#7
Bentao Shi
No abstract text is available yet for this article.
February 1, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28093172/re-lifestyle-factors-and-premature-ejaculation-are-physical-exercise-alcohol-consumption-and-body-mass-index-associated-with-premature-ejaculation-and-comorbid-erectile-problems
#8
https://www.readbyqxmd.com/read/28065363/relationship-between-amyloid-precursor-protein-in-seminal-plasma-and-abnormal-penile-sympathetic-skin-response-in-lifelong-premature-ejaculation
#9
Zhiwei Hong, Yuming Feng, Hualong Ding, Xuechun Hu, Jin-Chun Lu, Xie Ge, Yifeng Ge, Bing Yao
INTRODUCTION: Hyperactivity of the sympathetic nervous system can play an important role in lifelong premature ejaculation (PE). Our previous study found that amyloid precursor protein (APP) levels in seminal plasma of patients with PE were clearly increased. Amyloid-β (Aβ) is derived from APP. Excessive Aβ, especially Aβ42, can cause neuronal dysfunction. AIM: To determine whether APP and Aβ42 are associated with an abnormal penile sympathetic skin response (PSSR)...
January 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28053952/diagnosis-and-treatment-of-premature-ejaculation-by-urologists-in-south-korea
#10
Deok Ha Seo, Seong Uk Jeh, See Min Choi, Sung Chul Kam, Sae Woong Kim, Dae Yul Yang, Du Geon Moon, Sang Kuk Yang, Ki Ha Moon, Jae Seog Hyun
PURPOSE: This study discusses the treatment of premature ejaculation (PE) using various approaches with the goal of evaluating the methods of diagnosis and treatment of PE in clinical practice in 2014 in South Korea. MATERIALS AND METHODS: We surveyed 200 urologists and andrologists who treated patients with PE from July 1, 2014 to July 29, 2014 using an online questionnaire. The questionnaire was composed of 4 parts: disease, comorbidities, diagnosis, and treatment...
December 2016: World Journal of Men's Health
https://www.readbyqxmd.com/read/28053946/ancient-chinese-fangzhongshu-sexual-skills-and-methods-therapy-for-premature-ejaculation
#11
REVIEW
Yong Zhu, Qiang Chen, Yuexing Gu, Jin Yue, Qingqi Zeng
Premature ejaculation (PE) is a common male sexual dysfunction that can have significant effects on a couple's relationship. Behavioral therapy and psychotherapy are both safe and effective methods of treating PE. Ancient Chinese fangzhongshu (sexual skills and methods), which reflects a summary of expert experiences in sexology, contains many therapies for sexual dysfunction that are similar to those used in behavioral therapy or psychotherapy. A brief introduction dealing with the latest definitions of PE and treatment strategies drawn from behavioral therapy and psychotherapy is provided...
December 2016: World Journal of Men's Health
https://www.readbyqxmd.com/read/28041925/complementary-and-alternative-medicine-for-management-of-premature-ejaculation-a-systematic-review
#12
REVIEW
Katy Cooper, Marrissa Martyn-St James, Eva Kaltenthaler, Kath Dickinson, Anna Cantrell, Shijie Ren, Kevan Wylie, Leila Frodsham, Catherine Hood
INTRODUCTION: Premature ejaculation (PE) is defined as ejaculation within 1 minute (lifelong PE) or 3 minutes (acquired PE), inability to delay ejaculation, and negative personal consequences. Management includes behavioral and pharmacologic approaches. AIM: To systematically review effectiveness, safety, and robustness of evidence for complementary and alternative medicine in managing PE. METHODS: Nine databases including Medline were searched through September 2015...
March 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28041923/prevalence-and-associated-factors-of-premature-ejaculation-in-the-anhui-male-population-in-china-evidence-based-unified-definition-of-lifelong-and-acquired-premature-ejaculation
#13
Jingjing Gao, Dangwei Peng, Xiansheng Zhang, Zongyao Hao, Jun Zhou, Song Fan, Yao Zhang, Jun Mao, Xianming Dou, Chaozhao Liang
INTRODUCTION: In 2014, new evidence-based definitions of lifelong premature ejaculation (LPE) and acquired premature ejaculation (APE) were proposed by the International Society for Sexual Medicine. Based on the new PE definitions, the prevalence of and factors associated with LPE and APE have not been investigated in China. AIM: To evaluate the prevalence of and factors associated with LPE and APE in men with the complaint of PE in China. METHODS: From December 2011 to December 2015, a cross-sectional field survey was conducted in five cities in the Anhui province of China...
March 2017: Sexual Medicine
https://www.readbyqxmd.com/read/27993112/understanding-the-pathophysiology-of-premature-ejaculation-bridging-the-link-between-pharmacological-and-psychological-interventions
#14
Hatta Sidi, Farid Yusof, Srijit Das, Marhani Midin, Jaya Kumar, Muhammd Hizri Hatta
Premature ejaculation (PE) is one of the commonest male sexual dysfunctions. It is characterized by ejaculation which occurs before or soon after vaginal penetration, which causes significant psychological distress to the individual, and his partner. The exact cause of PE is still unknown but several mechanisms are proposed, and these involve complex interactions of neurophysiological, psychosocial, and cognitive factors. We discuss the role of serotonin, nitric oxide, phosphodiesterase enzymes and other neurotransmitters...
December 15, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27982691/no-evidence-for-long-term-causal-associations-between-symptoms-of-premature-ejaculation-and-symptoms-of-anxiety-depression-and-sexual-distress-in-a-large-population-based-longitudinal-sample
#15
Daniel Ventus, Annika Gunst, Antti Kärnä, Patrick Jern
Premature ejaculation (PE) is one of the most common male sexual complaints, but its etiology is unclear. Psychological problems, such as symptoms of anxiety and depression, have traditionally been seen as causal or maintaining etiological components of PE, and previous cross-sectional studies have found weak positive associations between them. The aim of the present study was to test possible causal pathways over time between PE and symptoms of the psychological problems anxiety, depression, and sexual distress...
February 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/27938992/sexual-sensation-seeking-sexual-compulsivity-and-gender-identity-and-its-relationship-with-sexual-functioning-in-a-population-sample-of-men-and-women
#16
Andrea Burri
INTRODUCTION: Despite awareness of the importance of psycho-affective factors in the development of sexual problems, there is a lack of studies exploring the relation of sexual sensation seeking (SSS) and sexual compulsivity (SC) to sexual functioning. Because sex differences in SSS and SC have been reported, gender identity (GI; an individual's own experience of his or her gender that is unrelated to the actual biological sex) might act as a moderator in this relation. AIM: To understand the role of SSS and SC for men and women's sexual functioning and to explore whether these potential associations are moderated by GI...
January 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27908635/from-the-definition-to-the-social-impact-of-premature-ejaculation-expert-consensus
#17
EDITORIAL
N Cruz-Navarro, R Prieto-Castro, F Cabello-Santamaría, F García-José, A Fernández-Lozano, M Larrazábal-Murillo, A Martín-Morales, F Sánchez-Sánchez, C San Martín-Blanco, J Viladoms-Fuster
No abstract text is available yet for this article.
November 28, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27890601/tramadol-effects-on-sexual-behavior-in-male-rats-are-mainly-caused-by-its-5-ht-reuptake-blocking-effects
#18
Jocelien D A Olivier, Diana C Esquivel Franco, Ronald Oosting, Marcel Waldinger, Zoltan Sarnyai, Berend Olivier
Tramadol is a well-known and effective analgesic. Recently it was shown that tramadol is also effective in human premature ejaculation. The inhibitory effect of tramadol on the ejaculation latency is probably due to its mechanism of action as a μ-opioid receptor agonist and noradrenaline/serotonin (5-HT) reuptake inhibitor. In order to test this speculation, we tested several doses of tramadol in a rat model of male sexual behavior and investigated two types of drugs interfering with the μ-opioid and the 5-HT system...
November 24, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27871957/tramadol-abuse-and-sexual-function
#19
REVIEW
Ibrahim A Abdel-Hamid, Karl-Erik Andersson, Marcel D Waldinger, Tarek H Anis
INTRODUCTION: Tramadol exhibits an effect profile similar to that of opioid agonists, and tramadol abuse seems to be a problem for a number of countries. The relationship between tramadol and sexual function appears to be controversial. Men with premature ejaculation (PE) may benefit from taking tramadol off label; however, these patients live "on a knife's edge" and are exquisitely sensitive to develop other sexual dysfunctions. AIM: To review the literature regarding the problem of tramadol abuse and its relationship with sexual function...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27860425/centrally-mediated-ejaculatory-response-via-sympathetic-outflow-in-rats-role-of-n-methyl-d-aspartic-acid-receptors-in-paraventricular-nucleus
#20
J-D Xia, J Chen, H-J Sun, L-H Zhou, G-Q Zhu, Y Chen, Y-T Dai
Ejaculation is mediated by a spinal generator, which integrates inputs related to the sexual activity and coordinates sympathetic, parasympathetic, and motor outflow. Previous clinical studies indicate that primary premature ejaculation is related to the hyperactivity of the sympathetic nervous system. In this study, we explored the roles of N-methyl-D-aspartic acid (NMDA) receptors in paraventricular nucleus of the hypothalamus (PVN) on ejaculatory responses and its potential mechanism in the rats. We found that microinjection of 0...
January 2017: Andrology
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