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https://www.readbyqxmd.com/read/29608897/uses-of-fluoxetine-in-nociceptive-pain-management-a-literature-overview
#1
REVIEW
Ahmed Barakat, Mostafa M Hamdy, Mohamed M Elbadr
Fluoxetine is one of the top ten prescribed antidepressants. Other therapeutic applications were approved for fluoxetine including, anxiety disorders, bulimia nervosa, and premature ejaculation. However, the role of fluoxetine in nociceptive pain management is still unclear. In this review, we discuss an overview of five possible roles of fluoxetine in pain management: intrinsic antinociceptive effect, enhancement of acute opioid analgesia, attenuation of tolerance development to opioid analgesia, attenuation of dependence development and abstinence syndrome, and attenuation of opioid induced hyperalgesia...
March 30, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29600795/no-effect-of-abstinence-time-on-nerve-electrophysiological-test-in-premature-ejaculation-patients
#2
Bai-Bing Yang, Jia-Dong Xia, Zhi-Wei Hong, Zheng Zhang, You-Feng Han, Yun Chen, Yu-Tian Dai
The nerve electrophysiological tests may differentiate the treatment of primary premature ejaculation (PPE) in our previous studies. However, no study verifies if the results will be affected by abstinence time. From January to December in 2016, fifty PPE patients ejaculated within 2 min and 28 control subjects were enrolled. The nerve electrophysiological tests, including dorsal nerve somatosensory evoked potential (DNSEP), glans penis somatosensory evoked potential (GPSEP), and penile sympathetic skin response (PSSR), were recorded before and immediately after ejaculation...
March 30, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29564281/a-case-report-of-over-the-counter-codeine-dependence-as-consequence-of-self-medication-for-premature-ejaculation
#3
Sethulakshmi Sreevalsam Anil, Badr Ratnakaran, Nisha Suresh
Over-the-counter (OTC) opioid abuse, including codeine, has been a growing problem around the world. Although the majority of the abusers use it for recreational purposes, many become dependent on it after having used it a medication for pain or cough. We present a case of codeine dependence where the initial prescribed use had been as a cough medication, but the subsequent abuse of it occurred the following self-medication for premature ejaculation. There is growing need for awareness among doctors and pharmacists of OTC abuse of opioids and for preventive interventions such as restricting supply, audit of pharmacies, training pharmacists, and counter staff and dispensing knowledge about proper use of opioid-containing medications to patients...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29556396/longer-trinucleotide-repeats-of-androgen-receptor-are-associated-with-higher-testosterone-and-low-oxytocin-levels-in-diabetic-premature-ejaculatory-dysfunction-patients
#4
Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Yousaf Latif Khan, Rosa Maria Marquez Gonzalez, Muhammad Aslamkhan, Gerardo Rodriguez Gonzalez, Hikmet Hakan Aydin
Background: Despite its worldwide high occurrence, the obscurity regarding the description, epidemiology and management of premature ejaculation remains provocative. It is well established that male premature ejaculatory dysfunction is an increasing problem due to spontaneous ejaculation across a variety of general and clinical subjects. The main goal of this study was to determine the relationships between trinucleotide repeats of the androgen receptor (AR), sex steroids, and pituitary hormones with sexual function in men with type 2 diabetes mellitus (DM) and reported with acquired premature ejaculation (PE)...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29532805/sexual-dysfunction-and-male-infertility
#5
REVIEW
Francesco Lotti, Mario Maggi
Infertility affects up to 12% of all men, and sexual dysfunction occurs frequently in men of reproductive age, causing infertility in some instances. In infertile men, hypoactive sexual desire and lack of sexual satisfaction are the most prevalent types of sexual dysfunction, ranging from 8.9% to 68.7%. Erectile dysfunction and/or premature ejaculation, evaluated with validated tools, have a prevalence of one in six infertile men, and orgasmic dysfunction has a prevalence of one in ten infertile men. In addition, infertile men can experience a heavy psychological burden...
March 13, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29527702/efficacy-and-safety-of-daily-use-of-tadalafil-in-treatment-of-patients-with-premature-ejaculation-a-randomised-placebo-controlled-clinical-trial
#6
M Abu El-Hamd
The study aimed to evaluate the efficacy and safety of the once-daily use of 5 mg tadalafil in the treatment of patients with premature ejaculation (PE). In a single-blind placebo-controlled clinical study, it was carried out on 100 patients with PE. All patients were randomised equally divided into two groups (50 patients each). Group 1 was given placebo in the form of oral multivitamin tablet once a day for 6 weeks. Group 2 was given 5 mg tadalafil once a day for 6 weeks. All patients were asked to complete Arabic Index of Premature Ejaculation (AIPE) before and after the treatment...
March 12, 2018: Andrologia
https://www.readbyqxmd.com/read/29523489/male-sexual-quality-of-life-is-maintained-satisfactorily-throughout-life-in-the-amazon-rainforest
#7
Thiago Teixeira, Maira Nazima, Jorge Hallak
INTRODUCTION: The Amazon Rainforest is a cradle of biodiversity, where different ethnic groups have specific sexual habits. AIMS: To define the average sexual quality of life of Amazonian men 18 to 69 years old, evaluate the influence of aging on their sexual function, and calculate the prevalence of premature ejaculation, delayed ejaculation, and hypoactive sexual desire disorder. METHODS: A cross-sectional quantitative probability sample study was performed with a demographically representative population (N = 385), with data collected privately at participants' houses, including men who had been sexually active for a minimum of 6 months...
March 6, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29523476/health-related-lifestyle-factors-and-sexual-dysfunction-a-meta-analysis-of-population-based-research
#8
REVIEW
Mark S Allen, Emma E Walter
BACKGROUND: Sexual dysfunction is a common problem among men and women and is associated with negative individual functioning, relationship difficulties, and lower quality of life. AIM: To determine the magnitude of associations between 6 health-related lifestyle factors (cigarette smoking, alcohol intake, physical activity, diet, caffeine, and cannabis use) and 3 common sexual dysfunctions (erectile dysfunction, premature ejaculation, and female sexual dysfunction)...
March 6, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29520842/mapping-the-landscape-of-urology-a-new-media-based-cross-sectional-analysis-of-public-versus-academic-interest
#9
Hendrik Borgmann, Johannes Salem, Martin Baunacke, Katharina Boehm, Christer Groeben, Marianne Schmid, Fabian P Siegel, Johannes Huber
OBJECTIVES: To quantify public and academic interest in the urological field using a novel new media-based methodology. METHODS: We systematically measured public and academic interest in 56 urological keywords and combined in nine subspecialties. Public interest was quantified as video views on YouTube. Academic interest was quantified as article citations using Microsoft Academic Search. The public-to-academic interest ratio was calculated for a comparison of subspecialties as well as for diseases and treatments...
March 8, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29497891/the-relationship-between-female-sexual-function-index-domains-and-premature-ejaculation
#10
Lütfi Canat, Recep Burak Değirmentepe, Hasan Anıl Atalay, İlter Alkan, Sait Özbir, Mehmet Gökhan Çulha, Alper Ötünçtemur
PURPOSE: The aim of this prospective, observational study was to investigate the relationship between premature ejaculation (PE) and female sexual response cycle, using the female sexual function index (FSFI). The FSFI evaluates female sexual function in six domains: desire, arousal, lubrication, orgasm, satisfaction, and pain. METHODS: All men were considered to have PE if they fulfilled the criteria of the second Ad Hoc International Society for Sexual Medicine (ISSM) Committee...
March 1, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29493183/sexual-complications-of-penile-frature-in-men-who-have-sex-with-men
#11
Rodrigo Barros, Gabriel Lacerda, Alex Schul, Paulo Ornellas, Leandro Koifman, Luciano A Favorito
OBJECTIVES: Evaluate the demographic data, etiology, operative findings and results of surgical treatment of penile fracture (PF) in men who have sex with men(MSM) with emphasis on sexual complications. MATERIALS AND METHODS: We studied 216 patients underwent surgical correction of PF at our hospital. Patients self-identified as MSM were followed for at least 6 months. Demographic data, presentation, operative findings, International Index of Erection Function - 5 (IIEF-5) and the Premature Ejaculation Diagnostic Tool...
March 1, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29463441/perineal-ultrasound-a-review-in-the-context-of-ejaculatory-dysfunction
#12
REVIEW
Connor M Forbes, Ryan Flannigan, Darius A Paduch
BACKGROUND: Ejaculation consists of the emission of semen from seminal vesicles and prostate, followed by expulsion. Ejaculatory dysfunction may take several forms including premature ejaculation, delayed or anejaculation, retrograde ejaculation, and painful ejaculation. Ejaculation is what we can see whereas orgasm is what we feel. The presence of ejaculate does not indicate the ability to experience orgasm. Hence, for the purpose of this work we consider orgasm and ejaculation as 2 separate neurobiological phenomena...
February 17, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29453817/endocrine-and-psychological-aspects-of-sexual-dysfunction-in-klinefelter-patients
#13
A Ferlin, R Selice, S Angelini, M Di Grazia, N Caretta, F Cavalieri, A Di Mambro, C Foresta
Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29432875/title-of-the-manuscript-new-tools-to-measure-ejaculatory-latency-arousal-to-ejaculation-time-interval-aeti-and-erection-to-ejaculation-time-interval-eeti-a-pilot-study
#14
Gajanan S Bhat, S Anuradha
OBJECTIVE: To evaluate the proposed novel tools, namely, Arousal to Ejaculation Time Interval (AETI) and Erection to Ejaculation Time Interval (EETI), to measure ejaculatory latency during different types of sexual encounters, in a pilot study. METHODS: The study period was from September 2016 to December 2016. After obtaining informed consent and institutional review board approval, the medical practitioners without any co-morbidity, who volunteered to participate, were asked to report the self assessed time taken to ejaculate following sexual arousal (AETI) and also following a sustained erection (EETI) during a sexual activity...
February 9, 2018: Urology
https://www.readbyqxmd.com/read/29430157/pregnancy-outcome-of-home-intravaginal-insemination-in-couples-with-unconsummated-marriage
#15
Kaberi Banerjee, Bhavana Singla
Unconsummated marriage are mainly due to vaginismus or erectile dysfunction. They contribute to about 5% of couples in an infertility clinic. Their incidence is increasing in the metropolitan cities because of stressful lifestyles. Many of couples are advised intrauterine insemination as fertility treatment. However, home insemination is a simple, inexpensive and effective way of achieving pregnancy in such couples. We present the first study to document pregnancy rates of artificial home intravaginal insemination in couples with unconsummated marriage...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29405168/penile-sensory-thresholds-in-subtypes-of-premature-ejaculation-implications-of-comorbid-erectile-dysfunction
#16
Xiang Chen, Fei-Xiang Wang, Chao Hu, Nian-Qin Yang, Ji-Can Dai
Penile hypersensitivity plays an important role in premature ejaculation (PE), but differences in penile sensitivity among subtypes of PE are unknown. Therefore, we compared penile sensory thresholds in PE subtypes of lifelong and acquired PE, PE with and without erectile dysfunction (ED), PE with an intravaginal ejaculation latency time ≤1 min and >1 min, and PE with and without orgasmic pleasure perceptual dysfunction. During August 2014 to January 2016, 136 patients with PE were included. Penile warm, cold, and vibratory thresholds were measured...
February 6, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29370617/re-validity-of-premature-ejaculation-diagnostic-tool-and-its-association-with-international-index-of-erectile-function-15-in-chinese-men-with-evidence-based-defined-premature-ejaculation
#17
https://www.readbyqxmd.com/read/29369372/effects-of-the-dopamine-d3-receptor-agonist-7-hydroxy-2-di-n-propylamino-tetralin-in-hyperthyroidism-induced-premature-ejaculation-rat-model
#18
O Cinar, N Durmus, G Aslan, O Demir, A S Evcim, S Gidener, A A Esen
Various factors are involved in the aetiology of premature ejaculation (PE). Hyperthyroidism is one of the causes of acquired PE, but the exact mechanism by which it causes the disorder is not yet understood. The aim of this study was to evaluate the role of the dopaminergic system in hyperthyroidism-induced PE by the intracerebroventricular microinjection of the preferentially active dopamine receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in a rat model of this disorder. Wistar rats were randomly divided into hyperthyroid and control groups, and ejaculation was induced by the ICV administration of 7-OH-DPAT...
January 25, 2018: Andrologia
https://www.readbyqxmd.com/read/29338524/visceral-adiposity-index-is-associated-with-premature-ejaculation-inversely-a-cross-sectional-study
#19
Suleyman Sami Cakir, Levent Ozcan, Huseyin Besiroglu, Murat Dursun, Emre Can Polat, Alper Otunctemur, Emin Ozbek
OBJECTIVE: Visceral adiposity index (VAI) is a novel indicator for the assessment of visceral obesity. In this study, we aimed to evaluate the relationship between VAI and premature ejaculation (PE). MATERIALS AND METHOD: A total of 300 men were included in the study. Hundred and fifty men with PE and 150 men without PE (control). All men were evaluated for PE by premature ejaculation diagnostic tool (PEDT). VAI levels were calculated using body mass index (BMI), high density lipoprotein and triglyceride (TG) levels...
January 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29325456/dual-purpose-vardenafil-hydrochloride-dapoxetine-hydrochloride-orodispersible-tablets-in-vitro-formulation-evaluation-stability-study-and-in-vivo-comparative-pharmacokinetic-study-in-healthy-human-subjects
#20
Khaled El-Refai, Mahmoud H Teaima, Mohamed A El-Nabarawi
Erectile dysfunction (ED) is the most important disorder after premature ejaculation for sexual activity in men. Vardenafil hydrochloride (VH) is an oral therapy for the treatment of erectile dysfunction. VH oral disintegrating tablets (ODTs) have been prepared by freeze drying technique to improve its dissolution profile and the overall clinical performance. Dapoxetine hydrochloride (DH) was added to the best three formulae of the prepared VH ODTs to treat premature ejaculation. All the ODTs formulae were evaluated for weight variation, friability, drug content, in vitro disintegration time, wetting time, and the dissolution study...
June 2018: Drug Development and Industrial Pharmacy
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