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Cassidy Clarity, Gato Gourley, Courtney Lyles, Sara Ackerman, Margaret A Handley, Dean Schillinger, Urmimala Sarkar, Joseph Conigliaro
No abstract text is available yet for this article.
February 10, 2017: Journal of General Internal Medicine
Worlanyo E Gato, Daniel A Hunter, Ian C Byrd, Christopher A Mays, Wilson Yau, Ji Wu
Synthetic nanomaterials have many unique chemical and physical properties, mainly due to their high specific surface area and quantum confinement effect. Specifically, titanium dioxide (TiO2 ) nanomaterial has high stability, anticorrosive, and photocatalytic properties. However, there are concerns over adverse biological effects resulting from bioeffects. This study was to investigate adverse effects associated with acute ingestion of TiO2 nanofiber (TDNF). TDNF was fabricated via electrospinning method, followed by dissolution in water...
February 9, 2017: Environmental Toxicology
Christopher A Mays, Daniel A Hunter, Wilson Yau, Worlanyo E Gato
BACKGROUND: A recent diabetes report revealed an increased incidence in diabetes including type 1-diabetes (T1D). The increase in the numbers of T1D incidences are thought to be related to environmental reasons such as the exposure to environmental chemicals including arylamine 2-aminoanthracene (2AA). T1D is an autoimmune disease of the pancreatic islet in which insulin-producing beta cells are destroyed by auto-reactive T-cells and monocytic cells. METHODS: The purpose of this study is to examine the extent to which 2AA exposure contributes to T1D...
2017: Journal of Diabetes and Metabolic Disorders
I Gatos, S Tsantis, G C Kagadis
PURPOSE: To assess the role of an automated Computer Aided Diagnosis (CAD) system in differentiation of Healthy Subjects to Chronic Liver Disease (CLD) Patients in terms of liver fibrosis (F0-F4), using Ultrasound Shear Wave Elastography (SWE). METHODS: Clinical Dataset consisted of 125 subjects, 55 Healthy (F0) whom condition was validated with Normal Biochemical Markers and clear Clinical History, and 70 with CLD (F1-F4) whom condition was validated with Liver Biopsy...
June 2016: Medical Physics
Beathriz G V Barbosa, Laura Fernandez-García, Eva Gato, Maria López, Lucia Blasco, Robson Souza Leão, Rodolpho M Albano, Begoña Fernández, Felipe-Fernández Cuenca, Álvaro Pascual, German Bou, Elizabeth A Marques, María Tomás
Acinetobacter spp. are found in 53% of air colonization samples from the hospital environment. In this work, we sequenced all the genome of airborne Acinetobacter sp. strain 5-2Ac02. We found important features at the genomic level in regards to the rhizome. By phylogenetic analysis, A. towneri was the species most closely related to Acinetobacter sp. 5-2Ac02.
December 8, 2016: Genome Announcements
Jayant V Rajan, Juliana Moura, Gato Gourley, Karina Kiso, Alexandre Sizilio, Ana Maria Cortez, Lee W Riley, Maria Amelia Veras, Urmimala Sarkar
BACKGROUND: Mobile technology to support community health has surged in popularity, yet few studies have systematically examined usability of mobile platforms for this setting. METHODS: We conducted a mixed-methods study of 14 community healthcare workers at a public healthcare clinic in São Paulo, Brazil. We held focus groups with community healthcare workers to elicit their ideas about a mobile health application and used this input to build a prototype app. A pre-use test survey was administered to all participants, who subsequently use-tested the app on three different devices (iPhone, iPad mini, iPad Air)...
November 17, 2016: BMC Medical Informatics and Decision Making
M López, A Rueda, J P Florido, L Blasco, E Gato, L Fernández-García, L Martínez-Martínez, F Fernández-Cuenca, J Pachón, J M Cisneros, J Garnacho-Montero, J Vila, J Rodríguez-Baño, A Pascual, G Bou, M Tomás
Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by acquiring mobile elements such as transposons, plasmids, and phages. In this study, we compared two genomes of A. baumannii clinical strains isolated in 2000 (ST-2_clon_2000) and 2010 (ST-2_clon_2010) from GenBank project PRJNA308422.
October 20, 2016: Genome Announcements
Jorge Gato, Anne Marie Fontaine
The present study seeks to ascertain the attitudes of Portuguese psychology students (future psychologists) toward the development of children adopted by lesbian and gay parents. Each participant (N = 182) read a vignette describing an adoption of a child by lesbian and gay persons. After reading the vignette, participants rated four different aspects of the future development of the adopted child (psychosocial adjustment, victimization, psychological disturbance, and normative sexuality). Furthermore, participants were asked about their gender, interpersonal contact with lesbians and gay men, gender role attitudes, and attitudes toward lesbians and gay men...
November 2016: Journal of Homosexuality
M López, L Álvarez-Fraga, E Gato, L Blasco, M Poza, L Fernández-García, G Bou, M Tomás
Increased expression of chromosomal genes for resistance-nodulation-cell division-type efflux systems plays a major role in the multidrug resistance of Acinetobacter baumannii Little is known about the genetic characteristics of clinical strains of Acinetobacter baumannii lacking the AdeABC pump. In this study, we sequenced the genome of clinical strain Ab421 GEIH-2010 (belonging to clone ST79/PFGE-HUI-1 from the GEIH-REIPI Ab. 2010 project) which lacks this efflux pump.
2016: Genome Announcements
Worlanyo E Gato, Daniel A Hunter, Shamaya L Whitby, Christopher A Mays, Wilson Yau
BACKGROUND: In recent times, there has been an increase in the incidence of type 2 diabetes mellitus (T2DM) particularly in children. Adipocyte dysfunction provide a critical link between obesity and insulin resistance resulting in diabetes outcome. Further, environmental chemical exposure during early years of life might be a significant contributing factor to the increase in the incidence of T2DM. This study tests the idea that exposure to environmental contaminants (2-aminoanthracene [2AA]) in utero will show effects in the adipose tissue (AT) that signify T2DM vulnerability...
December 2016: Diabetes & Metabolism Journal
Urmimala Sarkar, Gato I Gourley, Courtney R Lyles, Lina Tieu, Cassidy Clarity, Lisa Newmark, Karandeep Singh, David W Bates
BACKGROUND: Mobile applications or 'apps' intended to help people manage their health and chronic conditions are widespread and gaining in popularity. However, little is known about their acceptability and usability for low-income, racially/ethnically diverse populations who experience a disproportionate burden of chronic disease and its complications. OBJECTIVE: The objective of this study was to investigate the usability of existing mobile health applications ("apps") for diabetes, depression, and caregiving, in order to facilitate development and tailoring of patient-facing apps for diverse populations...
December 2016: Journal of General Internal Medicine
Traber Davis Giardina, Urmimala Sarkar, Gato Gourley, Varsha Modi, Ashley N D Meyer, Hardeep Singh
BACKGROUND: Diagnostic errors pose a significant threat to patient safety but little is known about public perceptions of diagnostic errors. A study published in BMJ Quality & Safety in 2014 estimated that diagnostic errors affect at least 5% of US adults (or 12 million) per year. We sought to explore online public reactions to media reports on the reported frequency of diagnostic errors in the US adult population. METHODS: We searched the World Wide Web for any news article reporting findings from the study...
March 2016: Diagnosis
Olga Lock, Eleucy Perez, Martha Villar, Diana Flores, Rosario Rojas
It is estimated that there are as many as 1400 plant species currently used in traditional Peruvian medicine; however, only a few have undergone scientific investigation. In this paper, we make a review of the botanical, chemical, pharmacological and clinical propierties of the most investigated Peruvian medicinal plants. The plant species selected for this review are: Smallanthus sonchifolius (yacon), Croton lechleri (sangre de grado), Uncaria tomentosa/U. guianensis (uña de gato), Lepidium meyenii (maca), Physalis peruviana (aguaymanto), Minthostachys mollis (muña), Notholaena nivea (cuti-cuti), Maytenus macrocarpa (chuchuhuasi), Dracontium loretense (jergon sacha), Gentianella nitida (hercampuri), Plukenetia volubilis (sacha inchi) and Zea mays (maiz morado)...
March 2016: Natural Product Communications
Maria Gato-Cañas, Hugo Arasanz, Idoia Blanco-Luquin, Estíbaliz Glaría, Virginia Arteta-Sanchez, Grazyna Kochan, David Escors
Immunotherapies are achieving clinical success for the treatment of many cancers. However, it has taken a long time to exploit the potential of the immune system for the treatment of human cancers. We cannot forget that this has been the consequence of very extensive work in basic research in preclinical models and in human patients. Thus, it is rather hard to compile all of it while giving a comprehensive view on this subject. Here we have attempted to give an overall perspective in immunotherapy of melanoma...
May 2016: Immunotherapy
Ilias Gatos, Stavros Tsantis, Stavros Spiliopoulos, Dimitris Karnabatidis, Ioannis Theotokas, Pavlos Zoumpoulis, Thanasis Loupas, John D Hazle, George C Kagadis
PURPOSE: Classify chronic liver disease (CLD) from ultrasound shear-wave elastography (SWE) imaging by means of a computer aided diagnosis (CAD) system. METHODS: The proposed algorithm employs an inverse mapping technique (red-green-blue to stiffness) to quantify 85 SWE images (54 healthy and 31 with CLD). Texture analysis is then applied involving the automatic calculation of 330 first and second order textural features from every transformed stiffness value map to determine functional features that characterize liver elasticity and describe liver condition for all available stages...
March 2016: Medical Physics
Sachin K Garg, Courtney R Lyles, Sara Ackerman, Margaret A Handley, Dean Schillinger, Gato Gourley, Veenu Aulakh, Urmimala Sarkar
BACKGROUND: Text messaging is an affordable, ubiquitous, and expanding mobile communication technology. However, safety net health systems in the United States that provide more care to uninsured and low-income patients may face additional financial and infrastructural challenges in utilizing this technology. Formative evaluations of texting implementation experiences are limited. We interviewed safety net health systems piloting texting initiatives to study facilitators and barriers to real-world implementation...
February 6, 2016: BMC Medical Informatics and Decision Making
José Garnacho-Montero, Antonio Gutiérrez-Pizarraya, Ana Díaz-Martín, José Miguel Cisneros-Herreros, María Eugenia Cano, Eva Gato, Carlos Ruiz de Alegría, Felipe Fernández-Cuenca, Jordi Vila, Luis Martínez-Martínez, M Del Mar Tomás-Carmona, Álvaro Pascual, Germán Bou, Jerónimo Pachón-Diaz, Jesús Rodríguez-Baño
INTRODUCTION: The main aim of this study was to assess changes in the epidemiology and clinical presentation of Acinetobacter baumannii over a 10-year period, as well as risk factors of mortality in infected patients. METHOD: Prospective, multicentre, hospital-based cohort studies including critically ill patients with A. baumannii isolated from any clinical sample were included. These were divided into a first period ("2000 study") (one month), and a second period ("2010 study") (two months)...
November 2016: Enfermedades Infecciosas y Microbiología Clínica
Diego Iglesias-Gato, Pernilla Wikström, Stefka Tyanova, Charlotte Lavallee, Elin Thysell, Jessica Carlsson, Christina Hägglöf, Jürgen Cox, Ove Andrén, Pär Stattin, Lars Egevad, Anders Widmark, Anders Bjartell, Colin C Collins, Anders Bergh, Tamar Geiger, Matthias Mann, Amilcar Flores-Morales
BACKGROUND: Clinical management of the prostate needs improved prognostic tests and treatment strategies. Because proteins are the ultimate effectors of most cellular reactions, are targets for drug actions and constitute potential biomarkers; a quantitative systemic overview of the proteome changes occurring during prostate cancer (PCa) initiation and progression can result in clinically relevant discoveries. OBJECTIVES: To study cellular processes altered in PCa using system-wide quantitative analysis of changes in protein expression in clinical samples and to identify prognostic biomarkers for disease aggressiveness...
May 2016: European Urology
M Gato, T Liechtenstein, I Blanco-Luquín, M I Zudaire, G Kochan, D Escors
Since the beginning of the 20th century, biomedical scientists have tried to take advantage of the natural anti-cancer activities of the immune system. However, all the scientific and medical efforts dedicated to this have not resulted in the expected success. In fact, classical antineoplastic treatments such as surgery, radio and chemotherapy are still first line treatments. Even so, there is a quantity of experimental evidence demonstrating that cancer cells are immunogenic. However, the effective activation of anti-cancer T cell responses closely depends on an efficient antigen presentation carried out by professional antigen presenting cells such as DC...
May 2015: Anales del Sistema Sanitario de Navarra
María Gato, Idoia Blanco-Luquin, Maribel Zudaire, Xabier Martínez de Morentin, Estela Perez-Valderrama, Aintzane Zabaleta, Grazyna Kochan, David Escors, Joaquín Fernandez-Irigoyen, Enrique Santamaría
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that are defined by their myeloid origin, immature state, and ability to potently suppress T-cell responses. They regulate immune responses and the population significantly increases in the tumor microenvironment of patients with glioma and other malignant tumors. For their study, MDSCs are usually isolated from the spleen or directly of tumors from a large number of tumor-bearing mice although promising ex vivo differentiated MDSC production systems have been recently developed...
January 2016: Proteomics
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