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Jorge Gato, Anne Marie Fontaine
The present study seeks to ascertain the attitudes of Portuguese psychology students (future psychologists) toward the development of children adopted by lesbian and gay parents. Each participant (N = 182) read a vignette describing an adoption of a child by lesbian and gay persons. After reading the vignette, participants rated four different aspects of the future development of the adopted child (psychosocial adjustment, victimization, psychological disturbance, and normative sexuality). Furthermore, participants were asked about their gender, interpersonal contact with lesbians and gay men, gender role attitudes, and attitudes toward lesbians and gay men...
November 2016: Journal of Homosexuality
M López, L Álvarez-Fraga, E Gato, L Blasco, M Poza, L Fernández-García, G Bou, M Tomás
Increased expression of chromosomal genes for resistance-nodulation-cell division-type efflux systems plays a major role in the multidrug resistance of Acinetobacter baumannii Little is known about the genetic characteristics of clinical strains of Acinetobacter baumannii lacking the AdeABC pump. In this study, we sequenced the genome of clinical strain Ab421 GEIH-2010 (belonging to clone ST79/PFGE-HUI-1 from the GEIH-REIPI Ab. 2010 project) which lacks this efflux pump.
2016: Genome Announcements
Worlanyo E Gato, Daniel A Hunter, Shamaya L Whitby, Christopher A Mays, Wilson Yau
BACKGROUND: In recent times, there has been an increase in the incidence of type 2 diabetes mellitus (T2DM) particularly in children. Adipocyte dysfunction provide a critical link between obesity and insulin resistance resulting in diabetes outcome. Further, environmental chemical exposure during early years of life might be a significant contributing factor to the increase in the incidence of T2DM. This study tests the idea that exposure to environmental contaminants (2-aminoanthracene [2AA]) in utero will show effects in the adipose tissue (AT) that signify T2DM vulnerability...
August 12, 2016: Diabetes & Metabolism Journal
Urmimala Sarkar, Gato I Gourley, Courtney R Lyles, Lina Tieu, Cassidy Clarity, Lisa Newmark, Karandeep Singh, David W Bates
BACKGROUND: Mobile applications or 'apps' intended to help people manage their health and chronic conditions are widespread and gaining in popularity. However, little is known about their acceptability and usability for low-income, racially/ethnically diverse populations who experience a disproportionate burden of chronic disease and its complications. OBJECTIVE: The objective of this study was to investigate the usability of existing mobile health applications ("apps") for diabetes, depression, and caregiving, in order to facilitate development and tailoring of patient-facing apps for diverse populations...
July 14, 2016: Journal of General Internal Medicine
Traber Davis Giardina, Urmimala Sarkar, Gato Gourley, Varsha Modi, Ashley N D Meyer, Hardeep Singh
BACKGROUND: Diagnostic errors pose a significant threat to patient safety but little is known about public perceptions of diagnostic errors. A study published in BMJ Quality & Safety in 2014 estimated that diagnostic errors affect at least 5% of US adults (or 12 million) per year. We sought to explore online public reactions to media reports on the reported frequency of diagnostic errors in the US adult population. METHODS: We searched the World Wide Web for any news article reporting findings from the study...
March 2016: Diagnosis
Olga Lock, Eleucy Perez, Martha Villar, Diana Flores, Rosario Rojas
It is estimated that there are as many as 1400 plant species currently used in traditional Peruvian medicine; however, only a few have undergone scientific investigation. In this paper, we make a review of the botanical, chemical, pharmacological and clinical propierties of the most investigated Peruvian medicinal plants. The plant species selected for this review are: Smallanthus sonchifolius (yacon), Croton lechleri (sangre de grado), Uncaria tomentosa/U. guianensis (uña de gato), Lepidium meyenii (maca), Physalis peruviana (aguaymanto), Minthostachys mollis (muña), Notholaena nivea (cuti-cuti), Maytenus macrocarpa (chuchuhuasi), Dracontium loretense (jergon sacha), Gentianella nitida (hercampuri), Plukenetia volubilis (sacha inchi) and Zea mays (maiz morado)...
March 2016: Natural Product Communications
Maria Gato-Cañas, Hugo Arasanz, Idoia Blanco-Luquin, Estíbaliz Glaría, Virginia Arteta-Sanchez, Grazyna Kochan, David Escors
Immunotherapies are achieving clinical success for the treatment of many cancers. However, it has taken a long time to exploit the potential of the immune system for the treatment of human cancers. We cannot forget that this has been the consequence of very extensive work in basic research in preclinical models and in human patients. Thus, it is rather hard to compile all of it while giving a comprehensive view on this subject. Here we have attempted to give an overall perspective in immunotherapy of melanoma...
May 2016: Immunotherapy
Ilias Gatos, Stavros Tsantis, Stavros Spiliopoulos, Dimitris Karnabatidis, Ioannis Theotokas, Pavlos Zoumpoulis, Thanasis Loupas, John D Hazle, George C Kagadis
PURPOSE: Classify chronic liver disease (CLD) from ultrasound shear-wave elastography (SWE) imaging by means of a computer aided diagnosis (CAD) system. METHODS: The proposed algorithm employs an inverse mapping technique (red-green-blue to stiffness) to quantify 85 SWE images (54 healthy and 31 with CLD). Texture analysis is then applied involving the automatic calculation of 330 first and second order textural features from every transformed stiffness value map to determine functional features that characterize liver elasticity and describe liver condition for all available stages...
March 2016: Medical Physics
Sachin K Garg, Courtney R Lyles, Sara Ackerman, Margaret A Handley, Dean Schillinger, Gato Gourley, Veenu Aulakh, Urmimala Sarkar
BACKGROUND: Text messaging is an affordable, ubiquitous, and expanding mobile communication technology. However, safety net health systems in the United States that provide more care to uninsured and low-income patients may face additional financial and infrastructural challenges in utilizing this technology. Formative evaluations of texting implementation experiences are limited. We interviewed safety net health systems piloting texting initiatives to study facilitators and barriers to real-world implementation...
2016: BMC Medical Informatics and Decision Making
José Garnacho-Montero, Antonio Gutiérrez-Pizarraya, Ana Díaz-Martín, José Miguel Cisneros-Herreros, María Eugenia Cano, Eva Gato, Carlos Ruiz de Alegría, Felipe Fernández-Cuenca, Jordi Vila, Luis Martínez-Martínez, M Del Mar Tomás-Carmona, Álvaro Pascual, Germán Bou, Jerónimo Pachón-Diaz, Jesús Rodríguez-Baño
INTRODUCTION: The main aim of this study was to assess changes in the epidemiology and clinical presentation of Acinetobacter baumannii over a 10-year period, as well as risk factors of mortality in infected patients. METHOD: Prospective, multicentre, hospital-based cohort studies including critically ill patients with A. baumannii isolated from any clinical sample were included. These were divided into a first period ("2000 study") (one month), and a second period ("2010 study") (two months)...
January 25, 2016: Enfermedades Infecciosas y Microbiología Clínica
Diego Iglesias-Gato, Pernilla Wikström, Stefka Tyanova, Charlotte Lavallee, Elin Thysell, Jessica Carlsson, Christina Hägglöf, Jürgen Cox, Ove Andrén, Pär Stattin, Lars Egevad, Anders Widmark, Anders Bjartell, Colin C Collins, Anders Bergh, Tamar Geiger, Matthias Mann, Amilcar Flores-Morales
BACKGROUND: Clinical management of the prostate needs improved prognostic tests and treatment strategies. Because proteins are the ultimate effectors of most cellular reactions, are targets for drug actions and constitute potential biomarkers; a quantitative systemic overview of the proteome changes occurring during prostate cancer (PCa) initiation and progression can result in clinically relevant discoveries. OBJECTIVES: To study cellular processes altered in PCa using system-wide quantitative analysis of changes in protein expression in clinical samples and to identify prognostic biomarkers for disease aggressiveness...
May 2016: European Urology
M Gato, T Liechtenstein, I Blanco-Luquín, M I Zudaire, G Kochan, D Escors
Since the beginning of the 20th century, biomedical scientists have tried to take advantage of the natural anti-cancer activities of the immune system. However, all the scientific and medical efforts dedicated to this have not resulted in the expected success. In fact, classical antineoplastic treatments such as surgery, radio and chemotherapy are still first line treatments. Even so, there is a quantity of experimental evidence demonstrating that cancer cells are immunogenic. However, the effective activation of anti-cancer T cell responses closely depends on an efficient antigen presentation carried out by professional antigen presenting cells such as DC...
May 2015: Anales del Sistema Sanitario de Navarra
María Gato, Idoia Blanco-Luquin, Maribel Zudaire, Xabier Martínez de Morentin, Estela Perez-Valderrama, Aintzane Zabaleta, Grazyna Kochan, David Escors, Joaquín Fernandez-Irigoyen, Enrique Santamaría
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that are defined by their myeloid origin, immature state, and ability to potently suppress T-cell responses. They regulate immune responses and the population significantly increases in the tumor microenvironment of patients with glioma and other malignant tumors. For their study, MDSCs are usually isolated from the spleen or directly of tumors from a large number of tumor-bearing mice although promising ex vivo differentiated MDSC production systems have been recently developed...
January 2016: Proteomics
Maria Gato-Cañas, Xabier Martinez de Morentin, Idoia Blanco-Luquin, Joaquin Fernandez-Irigoyen, Isabel Zudaire, Therese Liechtenstein, Hugo Arasanz, Teresa Lozano, Noelia Casares, Apirat Chaikuad, Stefan Knapp, David Guerrero-Setas, David Escors, Grazyna Kochan, Enrique Santamaría
Myeloid-derived suppressor cells (MDSCs) differentiate from bone marrow precursors, expand in cancer-bearing hosts and accelerate tumor progression. MDSCs have become attractive therapeutic targets, as their elimination strongly enhances anti-neoplastic treatments. Here, immature myeloid dendritic cells (DCs), MDSCs modeling tumor-infiltrating subsets or modeling non-cancerous (NC)-MDSCs were compared by in-depth quantitative proteomics. We found that neoplastic MDSCs differentially expressed a core of kinases which controlled lineage-specific (PI3K-AKT and SRC kinases) and cancer-induced (ERK and PKC kinases) protein interaction networks (interactomes)...
September 29, 2015: Oncotarget
Matthaia Ieronymaki, Maria Eleni Androutsou, Anna Pantelia, Irene Friligou, Molly Crisp, Kirsty High, Kirsty Penkman, Dimitrios Gatos, Theodore Tselios
A fast and efficient microwave (MW)-assisted solid-phase peptide synthesis protocol using the 2-chlorotrityl chloride resin and the Fmoc/tBu methodology, has been developed. The established protocol combines the advantages of MW irradiation and the acid labile 2-chlorotrityl chloride resin. The effect of temperature during the MW irradiation, the degree of resin substitution during the coupling of the first amino acids and the rate of racemization for each amino acid were evaluated. The suggested solid phase methodology is applicable for orthogonal peptide synthesis and for the synthesis of cyclic peptides...
September 2015: Biopolymers
Taryn Kratz Harreld, Sara Fowler, Melissa Drum, Al Reader, John Nusstein, Mike Beck
INTRODUCTION: Incision and drainage of symptomatic emergency patients with facial swelling is painful even after local anesthetics are administered. The purpose of this prospective, randomized, double-blind study was to compare the pain of infiltration and the pain of an incision and drainage procedure of a buffered versus a nonbuffered 4% lidocaine formulation in symptomatic emergency patients presenting with a diagnosis of pulpal necrosis, associated periapical area, and an acute clinical swelling...
October 2015: Journal of Endodontics
Pedro Carrilho-Ferreira, Doroteia Silva, Maria de Jesus Silva, Rui André, Manuel Gato Varela, António Nunes Diogo
Adult-onset Still's disease is a rare disorder with potentially severe clinical features, including cardiac involvement. This systemic inflammatory disease of unknown origin should be considered in the differential diagnosis of pericarditis, with or without pericardial effusion. Cardiac tamponade is a very rare sequela that requires an invasive approach, such as percutaneous or surgical pericardial drainage, in addition to the usual conservative therapy. The authors describe a case of adult-onset Still's disease rendered more difficult by pericarditis and cardiac tamponade, and they briefly review the literature on this entity...
June 2015: Texas Heart Institute Journal
Ilias Gatos, Stavros Tsantis, Stavros Spiliopoulos, Aikaterini Skouroliakou, Ioannis Theotokas, Pavlos Zoumpoulis, John D Hazle, George C Kagadis
PURPOSE: Detect and classify focal liver lesions (FLLs) from contrast-enhanced ultrasound (CEUS) imaging by means of an automated quantification algorithm. METHODS: The proposed algorithm employs a sophisticated segmentation method to detect and contour focal lesions from 52 CEUS video sequences (30 benign and 22 malignant). Lesion detection involves wavelet transform zero crossings utilization as an initialization step to the Markov random field model toward the lesion contour extraction...
July 2015: Medical Physics
George Deraos, Maria Rodi, Hubert Kalbacher, Kokona Chatzantoni, Fotios Karagiannis, Loukas Synodinos, Panayiotis Plotas, Apostolos Papalois, Nikolaos Dimisianos, Panagiotis Papathanasopoulos, Dimitrios Gatos, Theodore Tselios, Vasso Apostolopoulos, Athanasia Mouzaki, John Matsoukas
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system, and it has been established that autoreactive T helper (Th) cells play a crucial role in its pathogenesis. Myelin basic protein (MBP) epitopes are major autoantigens in MS, and the sequence MBP87-99 is an immunodominant epitope. We have previously reported that MBP87-99 peptides with modifications at principal T-cell receptor (TCR) contact sites suppressed the induction of EAE symptoms in rats and SJL/J mice, diverted the immune response from Th1 to Th2 and generated antibodies that did not cross react with the native MBP protein...
August 28, 2015: European Journal of Medicinal Chemistry
C S Taylor, R Garcia Gato, J Learmount, N A Aziz, C Montgomery, H Rose, C L Coulthwaite, J W McGarry, D W Forman, S Allen, R Wall, E R Morgan
The nematode Angiostrongylus vasorum is becoming more widely recorded globally, and is of increasing concern as a cause of disease in dogs. Apparent geographic spread is difficult to confirm due to a lack of standardized disease recording systems, increasing awareness among veterinary clinicians, and recent improvements in diagnostic technologies. This study examines the hypothesis that A. vasorum has spread in recent years by repeating the methods of a previous survey of the fox population. The hearts and lungs of 442 foxes from across Great Britain were collected and examined by dissection and flushing of the pulmonary circulation and microscopic inspection of tracheal scrapes...
August 2015: Parasitology
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