keyword
MENU ▼
Read by QxMD icon Read
search

Perro

keyword
https://www.readbyqxmd.com/read/28176220/does-early-response-to-intravenous-glucocorticoids-predict-the-final-outcome-in-patients-with-moderate-to-severe-and-active-graves-orbitopathy
#1
L Bartalena, G Veronesi, G E Krassas, W M Wiersinga, C Marcocci, M Marinò, M Salvi, C Daumerie, C Bournaud, M Stahl, L Sassi, C Azzolini, K G Boboridis, M P Mourits, M R Soeters, L Baldeschi, M Nardi, N Currò, A Boschi, M Bernard, G von Arx, P Perros, G J Kahaly
PURPOSE: Intravenous glucocorticoids (ivGCs) given as 12-weekly infusions are the first-line treatment for moderate-to-severe and active Graves' orbitopathy (GO), but they are not always effective. In this study, we evaluated whether response at 6 weeks correlated with outcomes at 12 (end of intervention) and 24 (follow-up) weeks, particularly in patients initially unresponsive. METHODS: Our database (Bartalena et al. J Clin Endocrinol Metab 97:4454-4463, 10), comprising 159 patients given three different cumulative doses of methylprednisolone (2...
February 7, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28162460/-230-steps-a-novel-tool-to-phenotype-and-rate-the-severity-of-painful-polyneuropathy
#2
J Scholz, J Rathmell, W David, D Chad, A Broderick, S Perros, N Shin, J Wells, J Davis, C DiMaggio, S Wang, S Tate
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28126608/oil-in-microgel-strategy-for-enzymatic-triggered-release-of-hydrophobic-drugs
#3
C A Busatto, H Labie, V Lapeyre, R Auzely-Velty, A Perro, N Casis, J Luna, D A Estenoz, V Ravaine
Polymer microgels have received considerable attention due to their great potential in the biomedical field as drug delivery systems. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan composed of N-acetyl-d-glucosamine and d-glucuronic acid. This polymer is biodegradable, nontoxic, and can be chemically modified. In this work, a co-flow microfluidic strategy for the preparation of biodegradable HA microgels encapsulating hydrophobic drugs is presented. The approach relies on: (i) generation of a primary oil-in-water (O/W) nanoemulsion by the ultrasonication method, (ii) formation of a double oil-in-water-in-oil emulsion (O/W/O) using microfluidics, and (iii) cross-linking of microgels by photopolymerization of HA precursors modified with methacrylate groups (HA-MA) present in the aqueous phase of the droplets...
January 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28090287/transcription-factors-transcriptional-coregulators-and-epigenetic-modulation-in-the-control-of-pulmonary-vascular-cell-phenotype-therapeutic-implications-for-pulmonary-hypertension-2015-grover-conference-series
#4
REVIEW
Soni S Pullamsetti, Frédéric Perros, Prakash Chelladurai, Jason Yuan, Kurt Stenmark
Pulmonary hypertension (PH) is a complex and multifactorial disease involving genetic, epigenetic, and environmental factors. Numerous stimuli and pathological conditions facilitate severe vascular remodeling in PH by activation of a complex cascade of signaling pathways involving vascular cell proliferation, differentiation, and inflammation. Multiple signaling cascades modulate the activity of certain sequence-specific DNA-binding transcription factors (TFs) and coregulators that are critical for the transcriptional regulation of gene expression that facilitates PH-associated vascular cell phenotypes, as demonstrated by several studies summarized in this review...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28000444/diagnosis-and-classification-of-17-diseases-from-1404-subjects-via-pattern-analysis-of-exhaled-molecules
#5
Morad K Nakhleh, Haitham Amal, Raneen Jeries, Yoav Y Broza, Manal Aboud, Alaa Gharra, Hodaya Ivgi, Salam Khatib, Shifaa Badarneh, Lior Har-Shai, Lea Glass-Marmor, Izabella Lejbkowicz, Ariel Miller, Samih Badarny, Raz Winer, John Finberg, Sylvia Cohen-Kaminsky, Frédéric Perros, David Montani, Barbara Girerd, Gilles Garcia, Gérald Simonneau, Farid Nakhoul, Shira Baram, Raed Salim, Marwan Hakim, Maayan Gruber, Ohad Ronen, Tal Marshak, Ilana Doweck, Ofer Nativ, Zaher Bahouth, Da-You Shi, Wei Zhang, Qing-Ling Hua, Yue-Yin Pan, Li Tao, Hu Liu, Amir Karban, Eduard Koifman, Tova Rainis, Roberts Skapars, Armands Sivins, Guntis Ancans, Inta Liepniece-Karele, Ilze Kikuste, Ieva Lasina, Ivars Tolmanis, Douglas Johnson, Stuart Z Millstone, Jennifer Fulton, John W Wells, Larry H Wilf, Marc Humbert, Marcis Leja, Nir Peled, Hossam Haick
We report on an artificially intelligent nanoarray based on molecularly modified gold nanoparticles and a random network of single-walled carbon nanotubes for noninvasive diagnosis and classification of a number of diseases from exhaled breath. The performance of this artificially intelligent nanoarray was clinically assessed on breath samples collected from 1404 subjects having one of 17 different disease conditions included in the study or having no evidence of any disease (healthy controls). Blind experiments showed that 86% accuracy could be achieved with the artificially intelligent nanoarray, allowing both detection and discrimination between the different disease conditions examined...
January 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/27857647/nutrition-chez-le-br%C3%A3-l%C3%A3
#6
G Perro
Nutrition is a challenge for burn patients. Emphasized points are early enteral amounts by means of a naso-gastric tube, semi-recumbent position > 30°, gastro-intestinal survey improved by kinetics, weight evolution, nutritional amounts assessment to prevent proteino-energetic deficiency. Feeding is difficult with children, as with seniors often associating a preexisting starvation. Nutritional supplements are useful in medium severity patients. For overweight patients, hypo caloric and hyperprotidic diet is the better choice...
March 31, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27816994/bmprii-influences-the-response-of-pulmonary-microvascular-endothelial-cells-to-inflammatory-mediators
#7
Leanda Vengethasamy, Aurélie Hautefort, Birger Tielemans, Catharina Belge, Frédéric Perros, Stijn Verleden, Elie Fadel, Dirk Van Raemdonck, Marion Delcroix, Rozenn Quarck
Mutations in the bone morphogenetic protein receptor (BMPR2) gene have been observed in 70 % of patients with heritable pulmonary arterial hypertension (HPAH) and in 11-40 % with idiopathic PAH (IPAH). However, carriers of a BMPR2 mutation have only 20 % risk of developing PAH. Since inflammatory mediators are increased and predict survival in PAH, they could act as a second hit inducing the development of pulmonary hypertension in BMPR2 mutation carriers. Our specific aim was to determine whether inflammatory mediators could contribute to pulmonary vascular cell dysfunction in PAH patients with and without a BMPR2 mutation...
November 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27698437/intravital-imaging-reveals-improved-kupffer-cell-mediated-phagocytosis-as-a-mode-of-action-of-glycoengineered-anti-cd20-antibodies
#8
Capucine L Grandjean, Fabricio Montalvao, Susanna Celli, David Michonneau, Beatrice Breart, Zacarias Garcia, Mario Perro, Olivier Freytag, Christian A Gerdes, Philippe Bousso
Anti-CD20 monoclonal antibodies (mAbs) represent an effective treatment for a number of B cell malignancies and autoimmune disorders. Glycoengineering of anti-CD20mAb may contribute to increased anti-tumor efficacy through enhanced antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADP) as reported by in vitro studies. However, where and how glycoengineered Ab may potentiate therapeutic responses in vivo is yet to be elucidated. Here, we have performed mouse liver transplants to demonstrate that the liver is sufficient to mediate systemic B cells depletion after anti-CD20 treatment...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27649290/translating-research-into-improved-patient-care-in-pulmonary-arterial-hypertension
#9
Sebastien Bonnet, Steeve Provencher, Christophe Guignabert, Frédéric Perros, Olivier Boucherat, Ralph Theo Schermuly, Paul M Hassoun, Marlene Rabinovitch, Mark R Nicolls, Marc Humbert
Despite important advances in its therapeutic management, pulmonary arterial hypertension (PAH) remains an incurable disease. Although numerous drugs exhibited beneficial effects in preclinical settings, only few have reached clinical trial phases, highlighting the challenges of translating preclinical investigations into clinical trials. Potential reasons for delayed PAH drug development may include the inherent limitations of the currently available animal and in vitro models, potential lack of appropriate standardization of the experimental design, regulatory agencies requirements, competing clinical trials and insufficient funding...
September 20, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27542000/serum-thyroglobulin-in-the-monitoring-of-differentiated-thyroid-cancer
#10
Carol Evans, Sarah Tennant, Petros Perros
Patients with differentiated thyroid cancer (DTC) usually have an excellent prognosis. Following surgical and radioiodine treatment to remove the cancer cells and suppressive doses of levothyroxine, long-term follow-up, including measurement of serum thyroglobulin (Tg) using a sensitive assay is required to detect recurrence. To interpret Tg results clinicians need to know the corresponding serum TSH concentration, have an appreciation of the clearance of Tg from patient serum following various interventions and the limitations of its measurement...
2016: Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
https://www.readbyqxmd.com/read/27539364/bromodomain-and-extra-terminal-protein-mimic-jq1-decreases-inflammation-in-human-vascular-endothelial-cells-implications-for-pulmonary-arterial-hypertension
#11
Sharon Mumby, Natalia Gambaryan, Chao Meng, Frederic Perros, Marc Humbert, S John Wort, Ian M Adcock
BACKGROUND AND OBJECTIVE: Nuclear factor kappa B (NF-kB)-mediated inflammatory gene expression and vascular endothelial cell proliferation/remodelling are implicated in the pathophysiology of the fatal disease, pulmonary arterial hypertension (PAH). Bromodomain and extra-terminal (BET) proteins are essential for the expression of a subset of NF-kB-induced inflammatory genes. BET mimics including JQ1+ prevent binding of BETs to acetylated histones and down-regulate the expression of selected genes...
January 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27458111/proteomic-analysis-of-vascular-smooth-muscle-cells-in-physiological-condition-and-in-pulmonary-arterial-hypertension-toward-contractile-versus-synthetic-phenotypes
#12
Alexis Régent, Kim Heang Ly, Sébastien Lofek, Guilhem Clary, Mathieu Tamby, Nicolas Tamas, Christian Federici, Cédric Broussard, Philippe Chafey, Emmanuelle Liaudet-Coopman, Marc Humbert, Frédéric Perros, Luc Mouthon
Vascular smooth muscle cells (VSMCs) are highly specialized cells that regulate vascular tone and participate in vessel remodeling in physiological and pathological conditions. It is unclear why certain vascular pathologies involve one type of vessel and spare others. Our objective was to compare the proteomes of normal human VSMC from aorta (human aortic smooth muscle cells, HAoSMC), umbilical artery (human umbilical artery smooth muscle cells, HUASMC), pulmonary artery (HPASMC), or pulmonary artery VSMC from patients with pulmonary arterial hypertension (PAH-SMC)...
October 2016: Proteomics
https://www.readbyqxmd.com/read/27412078/templated-growth-of-gold-satellites-on-dimpled-silica-cores
#13
C Chomette, E Duguet, S Mornet, E Yammine, V N Manoharan, N B Schade, C Hubert, S Ravaine, A Perro, M Tréguer-Delapierre
We synthesize robust clusters of gold satellites positioned with tetrahedral symmetry on the surface of a patchy silica core by adsorption and growth of gold on the patches. First we conduct emulsion polymerization of styrene in the presence of 52 nm silica seeds whose surface has been modified with methacryloxymethyltriethoxysilane (MMS). We derive four-dimple particles from the resulting silica/polystyrene tetrapods. Polystyrene chains are covalently bound to the silica surface within the dimples due to the MMS grafts and they may be thiolated to induce adsorption of 12 nm gold particles...
July 14, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27322439/a-standardized-clinical-evaluation-of-phenotypic-diversity-in-diabetic-polyneuropathy
#14
Joachim Scholz, James P Rathmell, William S David, David A Chad, Alithia C Broderick, Stephen G Perros, Naomi S Shin, Jenna L Wells, John B Davis, Charles J DiMaggio, Shuang Wang, Simon N Tate
Diabetic polyneuropathy (DPN) is a major cause of neuropathic pain and a frequent target condition in analgesic treatment trials. Differences in the clinical symptoms and signs associated with DPN suggest distinct pathophysiological mechanisms underlying nerve damage and dysfunction that are likely to have therapeutic relevance. The aim of this study was to develop a tool for the bedside assessment of painful neuropathies such as DPN that captures the diversity of phenotypes. Sixty-one patients with type 2 diabetes and painful neuropathy, 19 patients with painless DPN, 25 patients with type 2 diabetes but no clinical evidence of neuropathy, and 20 healthy control subjects completed a structured interview (47 items) and a standardized physical examination (39 items)...
October 2016: Pain
https://www.readbyqxmd.com/read/27242347/lithography-free-shell-substrate-isolation-for-core-shell-gaas-nanowires
#15
Tuomas Haggren, Alexander Pyymaki Perros, Hua Jiang, Teppo Huhtio, Joona-Pekko Kakko, Veer Dhaka, Esko Kauppinen, Harri Lipsanen
A facile and scalable lithography-free technique(5) for the rapid construction of GaAs core-shell nanowires incorporating shell isolation from the substrate is reported. The process is based on interrupting NW growth and applying a thin spin-on-glass (SOG) layer to the base of the NWs and resuming core-shell NW growth. NW growth occurred in an atmospheric pressure metalorganic vapour phase epitaxy (MOVPE) system with gold nanoparticles used as catalysts for the vapour-liquid-solid growth. It is shown that NW axial core growth and radial shell growth can be resumed after interruption and even exposure to air...
July 8, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27149112/role-for-runx2-in-proliferative-and-calcified-vascular-lesions-in-pulmonary-arterial-hypertension
#16
Grégoire Ruffenach, Sophie Chabot, Virginie F Tanguay, Audrey Courboulin, Olivier Boucherat, Francois Potus, Jolyane Meloche, Aude Pflieger, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Eve Tremblay, Barbara Girerd, Aurélie Hautefort, David Montani, Elie Fadel, Peter Dorfmuller, Marc Humbert, Frédéric Perros, Roxane Paulin, Steeve Provencher, Sébastien Bonnet
RATIONALE: Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). This is sustained in time by the down-regulation of miR-204. In systemic vascular diseases, reduced miR-204 expression promotes vascular biomineralization by augmenting the expression of the transcription factor RUNX2. Implication of RUNX2 in PAH-related vascular remodeling and presence of calcified lesions in PAH remains unexplored. OBJECTIVES: We hypothesized that RUNX2 is up-regulated in lungs of PAH patients, contributing to vascular remodeling and calcium-related biomineralization...
May 5, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27136995/near-field-to-far-field-characterization-of-speckle-patterns-generated-by-disordered-nanomaterials
#17
Valentina Parigi, Elodie Perros, Guillaume Binard, Céline Bourdillon, Agnès Maître, Rémi Carminati, Valentina Krachmalnicoff, Yannick De Wilde
We study the intensity spatial correlation function of optical speckle patterns above a disordered dielectric medium in the multiple scattering regime. The intensity distributions are recorded by scanning near-field optical microscopy (SNOM) with sub-wavelength spatial resolution at variable distances from the surface in a range which spans continuously from the near-field (distance ≪ λ) to the far-field regime (distance ≫ λ). The non-universal behavior at sub-wavelength distances reveals the connection between the near-field speckle pattern and the internal structure of the medium...
April 4, 2016: Optics Express
https://www.readbyqxmd.com/read/27113485/phosphodiesterase-type-5-inhibition-reduces-albuminuria-in-subjects-with-overt-diabetic-nephropathy
#18
Wim Scheele, Susan Diamond, Jeremy Gale, Valerie Clerin, Nihad Tamimi, Vu Le, Rosalind Walley, Fernando Grover-Páez, Christelle Perros-Huguet, Timothy Rolph, Meguid El Nahas
Diabetic nephropathy (DN) is the leading cause of ESRD worldwide. Reduced bioavailability or uncoupling of nitric oxide in the kidney, leading to decreased intracellular levels of the nitric oxide pathway effector molecule cyclic guanosine monophosphate (cGMP), has been implicated in the progression of DN. Preclinical studies suggest that elevating the cGMP intracellular pool through inhibition of the cGMP-hydrolyzing enzyme phosphodiesterase type 5 (PDE5) might exert renoprotective effects in DN. To test this hypothesis, the novel, highly specific, and long-acting PDE5 inhibitor, PF-00489791, was assessed in a multinational, multicenter, randomized, double-blind, placebo-controlled, parallel group trial of subjects with type 2 diabetes mellitus and overt nephropathy receiving angiotensin converting enzyme inhibitor or angiotensin receptor blocker background therapy...
November 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27099835/the-2016-european-thyroid-association-european-group-on-graves-orbitopathy-guidelines-for-the-management-of-graves-orbitopathy
#19
Luigi Bartalena, Lelio Baldeschi, Kostas Boboridis, Anja Eckstein, George J Kahaly, Claudio Marcocci, Petros Perros, Mario Salvi, Wilmar M Wiersinga
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease, though severe forms are rare. Management of GO is often suboptimal, largely because available treatments do not target pathogenic mechanisms of the disease. Treatment should rely on a thorough assessment of the activity and severity of GO and its impact on the patient's quality of life. Local measures (artificial tears, ointments and dark glasses) and control of risk factors for progression (smoking and thyroid dysfunction) are recommended for all patients...
March 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27045137/endothelial-to-mesenchymal-transition-an-evolving-paradigm-and-a-promising-therapeutic-target-in-pah
#20
EDITORIAL
Kurt R Stenmark, Maria Frid, Frédéric Perros
No abstract text is available yet for this article.
May 3, 2016: Circulation
keyword
keyword
98758
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"