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https://www.readbyqxmd.com/read/29677194/combined-intervention-of-swimming-plus-metformin-ameliorates-the-insulin-resistance-and-impaired-lipid-metabolism-in-murine-gestational-diabetes-mellitus
#1
Liping Huang, Pingping Yue, Xuefei Wu, Ting Yu, Yang Wang, Ji Zhou, Derun Kong, Keyang Chen
Gestational diabetes mellitus (GDM) has short- and long- term influence on pregnant women and fetus. Swimming, as an aerobic exercise, can effectively improve the blood glucose level in GDM, but the effect of mild swimming alone was not very substantial. Metformin, as an oral antidiabetic drug, has obvious hypoglycemic effect, and is economic also, but the long-term effect on pregnant women and fetus has not been completely clear. We hypothesize that combined intervention of mild swimming and low dose of metformin, may effectively reduce blood glucose, improve the pregnancy outcomes in GDM dams, but simultaneously avoiding the adverse effects caused by overdose of drug and impotence of mild swimming...
2018: PloS One
https://www.readbyqxmd.com/read/29670384/screening-and-management-of-gestational-diabetes-in-mexico-results-from-a-survey-of-multilocation-multi-health-care-institution-practitioners
#2
Livia Dainelli, Alberto Prieto-Patron, Irma Silva-Zolezzi, Sandra G Sosa-Rubi, Salvador Espino Y Sosa, Enrique Reyes-Muñoz, Ruy Lopez-Ridaura, Patrick Detzel
Purpose: To identify the most common practices implemented for the screening and treatment of gestational diabetes mellitus (GDM) and to estimate the GDM clinician-reported proportion as a proxy of the incidence in Mexico. Materials and methods: Three hundred fifty-seven physicians in four major cities were asked about their practices regarding GDM screening, treatment, clinical exams, and health care staff involved in case of GDM diagnosis, as well as the percentage of women with GDM they care for...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29668814/sexual-behavior-and-associated-factors-in-rural-adolescents
#3
Bárbara Cabral de Sousa, Rebeca Silva Dos Santos, Katiuscy Carneiro Santana, Raquel Souzas, Álvaro Jorge Madeiro Leite, Danielle Souto de Medeiros
OBJECTIVE: To describe the sexual behavior and to identify associated factors in adolescents from rural communities in Bahia, Brazil. METHODS: This is a cross-sectional, population-based, and household-based study, carried out in 2015 with adolescents aged 10 to 19 years. We described the variables of sexual intercourse in life and in the last 12 months, age at first intercourse, condom use and number of partners, guidance on pregnancy, AIDS, or other sexually transmitted infections, and guidance on how to get condoms...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29668027/heart-transplant-in-children-what-a-primary-care-provider-needs-to-know
#4
Swati Sehgal, Emily Shea, Lauren Kelm, Deepak Kamat
Heart transplantation is offered to children with heart failure that is not amenable to medical or surgical therapy. Indications for heart transplant include unrepairable congenital heart disease, failed palliation of congenital heart disease, and cardiomyopathies. There has been tremendous progress in this field since the first heart transplant was performed in 1967. Each year, approximately 500 pediatric heart transplants take place worldwide. Pediatric heart transplant survivors are living longer with their initial transplant...
April 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29642862/effectiveness-and-safety-of-moderate-intensity-aerobic-water-exercise-during-pregnancy-for-reducing-use-of-epidural-analgesia-during-labor-protocol-for-a-randomized-clinical-trial
#5
Araceli Navas, Catalina Artigues, Alfonso Leiva, Elena Portells, Aina Soler, Antonia Cladera, Silvia Ortas, Margarita Alomar, Marina Gual, Concepción Manzanares, Marina Brunet, Magdalena Julià, Lidia López, Lorena Granda, Miquel Bennasar-Veny, Mari Carmen Carrascosa
BACKGROUND: Epidural analgesia during labor can provide effective pain relief, but can also lead to adverse effects. The practice of moderate exercise during pregnancy is associated with an increased level of endorphins in the blood, and this could also provide pain relief during labor. Aerobic water exercises, rather than other forms of exercise, do not negatively impact articulations, reduce edema, blood pressure, and back pain, and increase diuresis. We propose a randomized controlled trial (RCT) to evaluate the effectiveness and safety of a moderate water exercise program during pregnancy on the need for epidural analgesia during labor...
April 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29630009/pregnancy-exercise-and-nutrition-with-smartphone-application-support-a-randomized-controlled-trial
#6
Maria A Kennelly, Kate Ainscough, Karen L Lindsay, Elizabeth OʼSullivan, Eileen R Gibney, Mary McCarthy, Ricardo Segurado, Giuseppe DeVito, Orla Maguire, Thomas Smith, Mensud Hatunic, Fionnuala M McAuliffe
OBJECTIVE: To evaluate the effect of a healthy lifestyle package (an antenatal behavior change intervention supported by smartphone application technology) on the incidence of gestational diabetes mellitus (GDM) in overweight and obese women. METHODS: Women with body mass indexes (BMIs) 25-39.9 were enrolled into this randomized controlled trial. The intervention consisted of specific dietary and exercise advice that addressed behavior change supported by a tailor-designed smartphone application...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29628054/women-s-self-reported-factors-that-influence-their-postpartum-exercise-levels
#7
REVIEW
Susan Liipfert Shelton, Shih-Yu Sylvia Lee
The birth of a child is a life transition that can signal an opportunity to promote wellness and self-care. Nurses and other health care providers can encourage women to engage in exercise for physical and mental health and to enhance weight loss after birth. However, incorporating an exercise routine into life with an infant can be challenging. Sixty-two women provided feedback about their exercise patterns before and during pregnancy, and 18 of these women gave additional insight into barriers to and facilitators of exercise engagement after childbirth...
April 2018: Nursing for Women's Health
https://www.readbyqxmd.com/read/29627447/gestational-diabetes-mellitus-multi-disciplinary-treatment-approaches
#8
Evangelia Kintiraki, Dimitrios G Goulis
Gestational Diabetes Mellitus (GDM) is the most common metabolic disease of pregnancy, associated with several perinatal complications. Adequate glycemic control has been proved to decrease risk of GDM-related complications. Several studies have shown the beneficial effect of exercise and medical nutrition treatment on glycemic and weight control in GDM-affected women. Moreover, pharmacological agents, such as insulin and specific oral anti-diabetic agents can be prescribed safely during pregnancy, decreasing maternal blood glucose and, thus, perinatal adverse outcomes...
April 5, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29622455/-how-long-will-i-continue-to-be-normal-adults-with-a-fontan-circulation-s-greatest-concerns
#9
Karin du Plessis, Rebecca Peters, Ingrid King, Kirsty Robertson, Jonathan Mackley, Rachel Maree, Tracy Stanley, Louise Pickford, Brian Rose, Matthew Orchard, Helen Stewart, Yves d'Udekem
BACKGROUND: Little is known about adults living with a Fontan circulation's concerns outside the scope of their clinical outcomes. We examined adults with a Fontan circulations' greatest concerns, as well as their concerns around anti-coagulation, pregnancy and finances. METHODS: Adults with a Fontan circulation in the Australian and New Zealand Fontan Registry were invited to complete an anonymous online survey, of which 57 participated. A qualitative method approach using thematic analyses was used...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29610328/ectopic-neurogenesis-induced-by-prenatal-antiepileptic-drug-exposure-augments-seizure-susceptibility-in-adult-mice
#10
Atsuhiko Sakai, Taito Matsuda, Hiroyoshi Doi, Yukiko Nagaishi, Kiyoko Kato, Kinichi Nakashima
Epilepsy is a neurological disorder often associated with seizure that affects ∼0.7% of pregnant women. During pregnancy, most epileptic patients are prescribed antiepileptic drugs (AEDs) such as valproic acid (VPA) to control seizure activity. Here, we show that prenatal exposure to VPA in mice increases seizure susceptibility in adult offspring through mislocalization of newborn neurons in the hippocampus. We confirmed that neurons newly generated from neural stem/progenitor cells (NS/PCs) are integrated into the granular cell layer in the adult hippocampus; however, prenatal VPA treatment altered the expression in NS/PCs of genes associated with cell migration, including CXC motif chemokine receptor 4 ( Cxcr4 ), consequently increasing the ectopic localization of newborn neurons in the hilus...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29607854/risk-factors-for-breast-cancer-among-indian-women-a-case-control-study
#11
M P Antony, B Surakutty, T A Vasu, M Chisthi
Background: Breast cancer is the most common malignancy among females all over the world. The incidence of breast cancer is persistently on the rise due to urbanization and lifestyle changes. Although various risk factors have been suggested for estimating the risk of developing breast cancer, most of these have been studied in the Western population. A better understanding of local characteristics of risk factors may help in devising locally effective prevention strategies for breast cancer...
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29602890/childhood-obesity-in-mexico-social-determinants-of-health-and-other-risk-factors
#12
David Avelar Rodriguez, Erick Manuel Toro Monjaraz, Karen Rubi Ignorosa Arellano, Jaime Ramirez Mayans
Approximately 50 million children and adolescents in Latin America are affected by the childhood obesity pandemic. We present the case of a 5-year-old Mexican girl with obesity and gastro-oesophageal reflux disease (GORD), in whom prenatal, lifestyle and environmental risk factors were identified. Here, we demonstrate how childhood obesity is rooted since pregnancy and the perinatal stage, and how the social determinants of health like unsafe outdoor conditions, lack of infrastructure to exercise and a suboptimal physical activity curriculum in government schools strongly influence the development and maintenance of childhood obesity and complicate management...
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29601268/influence-of-a-concurrent-exercise-training-program-during-pregnancy-on-colostrum-and-mature-human-milk-inflammatory-markers-findings-from-the-gestafit-project
#13
Virginia A Aparicio, Olga Ocón, Javier Diaz-Castro, Pedro Acosta-Manzano, Irene Coll-Risco, Milkana Borges-Cósic, Lidia Romero-Gallardo, Jorge Moreno-Fernández, Julio J Ochoa-Herrera
BACKGROUND: Although exercise reduces systemic inflammation, information regarding its influence on human milk is scarce or inexistent. Research Aim: The aim of this study was to investigate the influence of an exercise intervention during pregnancy on colostrum and mature human milk inflammatory markers. METHODS: The authors conducted a pseudorandomized controlled trial. The exercise group followed a concurrent aerobic and strength training, three 60-minutes sessions per week, from the 17th gestational week until delivery...
March 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29581094/prenatal-remote-monitoring-of-women-with-gestational-hypertensive-diseases-cost-analysis
#14
Dorien Lanssens, Thijs Vandenberk, Christophe Jp Smeets, Hélène De Cannière, Sharona Vonck, Jade Claessens, Yenthel Heyrman, Dominique Vandijck, Valerie Storms, Inge M Thijs, Lars Grieten, Wilfried Gyselaers
BACKGROUND: Remote monitoring in obstetrics is relatively new; some studies have shown its effectiveness for both mother and child. However, few studies have evaluated the economic impact compared to conventional care, and no cost analysis of a remote monitoring prenatal follow-up program for women diagnosed with gestational hypertensive diseases (GHD) has been published. OBJECTIVE: The aim of this study was to assess the costs of remote monitoring versus conventional care relative to reported benefits...
March 26, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29562760/maternal-interventions-to-improve-offspring-outcomes-in-rodent-models-of-diet-induced-obesity-a-review
#15
Daniela Menichini, Monica Longo, Fabio Facchinetti
Maternal obesity is an adverse factor that affects the intrauterine environment during critical periods of fetal developmental causing adverse lifelong effects on offspring health. Several different interventions have been performed in animal models of obesity to ameliorate maternal conditions and consequently reduce the adverse effects on offspring. Our aim was to critically review studies involving murine models of obesity induced by high fat diet (HFD), assessing maternal outcomes during pregnancy and the related offspring conditions...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29561188/short-term-sitagliptin-metformin-therapy-is-more-effective-than-metformin-or-placebo-in-prior-gestational-diabetic-women-with-impaired-glucose-regulation
#16
Karen E Elkind-Hirsch, Martha S Paterson, Donna Shaler, Hanh C Gutowski
OBJECTIVE: Our pilot study examined the effectiveness of sitagliptin-metformin (SITA-MET), metformin (MET), and placebo (P) therapy on fasting and post-glucose challenge glucose levels in postpartum women with prior gestational diabetes mellitus (GDM) and impaired glucose regulation. METHODS: Prediabetic women (N = 36, age 18 to 42 years) with recent GDM were randomized to P (one pill twice a day), MET (1,000 mg twice a day), or SITA-MET (50 mg SITA, 1,000 mg MET twice a day) for 16 weeks in a single-blind fashion...
March 21, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29560763/pre-and-peripartal-management-of-a-woman-with-mcardle-disease-a-case-report
#17
Tina Stopp, Michael Feichtinger, Wolfgang Eppel, Thomas M Stulnig, Peter Husslein, Christian Göbl
McArdle disease or glycogen storage disease (GSD) type V is a rare autosomal recessive inherited disorder in skeletal muscle metabolism leading to exercise intolerance, muscle cramps and in some cases to rhabdomyolysis and acute renal failure due to elevated serum myoglobin levels. Albeit the uterine smooth muscle is not affected, pregnancy and delivery can be physically strenuous and may require specific anesthesiologic care. However, data on pregnancy progress and outcome and on special implications linked to anesthesia in women with McArdle's disease is scarce, thus posing a challenge to pre- and peripartal management...
March 21, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29551732/physical-exercise-improves-cognitive-function-by-enhancing-hippocampal-neurogenesis-and-inhibiting-apoptosis-in-male-offspring-born-to-obese-mother
#18
Tae-Woon Kim, Hye-Sang Park
Maternal obesity induces hippocampal functional changes and leads to deficits in cognitive functions, such as learning and memory in offspring. We investigated the protective effects of physical exercise against cognitive function deficit in offspring born to obese mothers. Neurotrophic factors, neurogenesis, and apoptosis were analyzed in the hippocampus and dentate gyrus of offspring. Four-week-old female rats were fed a high-fat diet (HFD) for 20 weeks: 12 weeks prior to mating, and 8 weeks during pregnancy and breast-feeding...
March 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29543356/vital-change-for-mums-a-feasibility-study-investigating-tailored-nutrition-and-exercise-care-delivered-by-video-consultations-for-women-3-12-months-postpartum
#19
L Vincze, M E Rollo, M J Hutchesson, R Callister, C E Collins
BACKGROUND: A tailored approach to nutrition and physical activity advice can support women following childbirth in managing barriers (i.e. time and childcare) to making healthy lifestyle changes. The aim of the present study was to evaluate the implementation, acceptability and preliminary efficacy of a personally tailored nutrition and exercise programme for postpartum women delivered via video-consultations by an accredited practising dietitian (APD) and accredited exercise physiologist (AEP)...
March 15, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29542188/correlates-of-accelerometer-assessed-physical-activity-in-pregnancy-the-2015-pelotas-brazil-birth-cohort-study
#20
Shana Ginar da Silva, Kelly R Evenson, Inácio Crochemore M Silva, Márcio A Mendes, Marlos R Domingues, Mariângela F Silveira, Fernando C Wehrmeister, Ulf Ekelund, Pedro C Hallal
Objective methods to measure physical activity (PA) have become available and widely used given the high degree of precision to evaluate PA. However, few studies have used accelerometers to measure PA during pregnancy, especially in low-and-middle income countries. We assessed overall PA, moderate, vigorous and moderate-to-vigorous physical activity (MVPA) objectively-measured among pregnant women and their correlates in a population-based study. PA was assessed for seven consecutive days using a raw triaxial wrist-worn accelerometer in women interviewed around 16 and 24 weeks of gestation in the 2015 Pelotas (Brazil) Birth Cohort Study...
March 14, 2018: Scandinavian Journal of Medicine & Science in Sports
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