keyword
https://read.qxmd.com/read/31908689/gonadotropin-versus-follicle-stimulating-hormone-for-ovarian-response-in-patients-undergoing-in-vitro-fertilization-a-retrospective-cohort-comparison
#21
JOURNAL ARTICLE
Zhisong Ji, Xiaozhen Quan, Yanli Lan, Meng Zhao, Xiaolong Tian, Xuezhou Yang
Background: Poor ovarian responders generally refer to patients who respond poorly to ovarian stimulation for assisted reproductive techniques (ART) such as in-vitro fertilization (IVF) and hence experience low live birth rate. Various controlled ovarian stimulation (COS) protocols have been developed during the past 3 decades for IVF/ICSI to improve oocyte quality and ultimately live birth rate, to increase ovarian response in POR patients, and to reduce the risk of ovarian hyperstimulation syndrome...
2020: Current Therapeutic Research, Clinical and Experimental
https://read.qxmd.com/read/31398248/dna-methylation-and-mrna-expression-of-imprinted-genes-in-blastocysts-derived-from-an-improved-in-vitro-maturation-method-for-oocytes-from-small-antral-follicles-in-polycystic-ovary-syndrome-patients
#22
JOURNAL ARTICLE
M D Saenz-de-Juano, E Ivanova, S Romero, F Lolicato, F Sánchez, H Van Ranst, F Krueger, A Segonds-Pichon, M De Vos, S Andrews, J Smitz, G Kelsey, E Anckaert
STUDY QUESTION: Does imprinted DNA methylation or imprinted gene expression differ between human blastocysts from conventional ovarian stimulation (COS) and an optimized two-step IVM method (CAPA-IVM) in age-matched polycystic ovary syndrome (PCOS) patients? SUMMARY ANSWER: No significant differences in imprinted DNA methylation and gene expression were detected between COS and CAPA-IVM blastocysts. WHAT IS KNOWN ALREADY: Animal models have revealed alterations in DNA methylation maintenance at imprinted germline differentially methylated regions (gDMRs) after use of ARTs...
September 29, 2019: Human Reproduction
https://read.qxmd.com/read/31385725/contribution-of-recruitable-follicles-to-circulating-anti-m%C3%A3-llerian-hormone-levels-following-maximal-gonadotrophin-stimulation-in-patients-with-limited-ovarian-reserve
#23
JOURNAL ARTICLE
Anna García-Alix Grynnerup, Kristine Løssl, Fie Pilsgaard, Jeanette Wulff Bogstad, Lisbeth Prætorius, Anne Zedeler, Stine Aagaard Lunding, Leif Bungum, Anders Nyboe Andersen, Anja Pinborg
In women, the majority of anti-Müllerian hormone (AMH) measured in serum originate from small antral follicles measuring 2-10 mm. In gonadotrophin-stimulated cycles prior to assisted reproductive technology (ART), most of the recruitable follicles develop beyond 10 mm in size and thus lose their AMH secretion capacity causing declining serum AMH levels. The aim of this study was to define the residual serum AMH level after elimination of the AMH producing recruitable follicles following maximal gonadotrophin stimulation...
August 6, 2019: Gynecological Endocrinology
https://read.qxmd.com/read/31262644/aberrant-endometrial-steroid-receptor-expression-in-in-vitro-maturation-cycles-despite-hormonal-luteal-support-a-pilot-study
#24
JOURNAL ARTICLE
Carolina Ortega-Hrepich, Panagiotis Drakopoulos, Claire Bourgain, Inge Van Vaerenbergh, Luis Guzman, Herman Tournaye, Johan Smitz, Michel De Vos
Clinical outcomes of fresh embryo transfer in non-hCG triggered in vitro maturation (IVM) cycles are inferior compared to vitrified-warmed embryo transfer. This is a prospective observational pilot study in a consecutive cohort of 31 polycystic ovary syndrome (PCOS) patients and 37 normo-ovulatory egg donors who underwent IVM without fresh embryo transfer between July 2009 and June 2014. All subjects received 150 IU of highly purified menotropin (HP-hMG) daily for three days. On cycle day 6, all patients started transdermal oestradiol (E2) at a daily dose of 9 mg...
June 2019: Reproductive Biology
https://read.qxmd.com/read/31206036/required-amount-of-rfsh-hp-hmg-and-hp-fsh-to-reach-a-live-birth-a-systematic-review-and-meta-analysis
#25
REVIEW
E M Bordewijk, F Mol, F van der Veen, M Van Wely
STUDY QUESTION: In women undergoing IVF or ICSI cycles, do recombinant gonadotrophins differ from urinary-derived highly purified human menopausal gonadotropin (HP-hMG) or highly purified follicle-stimulating hormone (HP-FSH) in the total amount of gonadotrophins required to reach a live birth? SUMMARY ANSWER: The difference between recombinant and urinary-derived HP-hMG or HP-FSH in the required amount to reach a live birth in IVF/ICSI cycles appears small. WHAT IS KNOWN ALREADY: At present, gynecologists can choose between recombinant FSH (rFSH), urinary-derived HP-hMG and HP-FSH...
2019: Human Reproduction Open
https://read.qxmd.com/read/30973022/the-impact-of-adding-hp-hmg-in-r-fsh-started-gnrh-antagonist-cycles-on-art-outcome
#26
JOURNAL ARTICLE
Ozgur Kan, Coskun Simsir, Cem Somer Atabekoglu, Murat Sonmezer
While luteinizing hormone (LH) activity is believed to play a role in follicle maturation, human chorionic gonadotropin (hCG) might play an important role in implantation process. We aimed to investigate whether addition of human menopausal gonadotropin (hMG) in recombinant-follicle-stimulating hormone (r-FSH) started GnRH antagonist controlled ovarian hyperstimulation (COH) cycles might enhance implantation rate and improve in vitro fertilization (IVF) success. A total of 246 patients undergoing GnRH antagonist IVF cycles were analyzed...
April 11, 2019: Gynecological Endocrinology
https://read.qxmd.com/read/30967840/cumulative-live-birth-rates-following-stimulation-with-corifollitropin-alfa-compared-with-hp-hmg-in-a-gnrh-antagonist-protocol-in-poor-ovarian-responders
#27
JOURNAL ARTICLE
Joaquín Errázuriz, Alessia Romito, Panagiotis Drakopoulos, Billie Frederix, Analissa Racca, Neelke De Munck, Herman Tournaye, Michel De Vos, Christophe Blockeel
Background: Bologna criteria poor ovarian responders have a very low prognosis. Although, it has been proposed that LH supplementation could be beneficial in women with previous hypo-response to FSH. There are no studies comparing the cumulative live birth rates (LBRs) between corifollitropin alfa (CFA) and highly purified human menopausal gonadotrophin (hp-hMG). Objective: To compare cumulative LBRs in Bologna poor ovarian responders undergoing ovarian stimulation with CFA followed by hp-hMG vs. hp-hMG alone in a GnRH antagonist protocol...
2019: Frontiers in Endocrinology
https://read.qxmd.com/read/30648738/gonadotrophins-for-ovulation-induction-in-women-with-polycystic-ovary-syndrome
#28
JOURNAL ARTICLE
Nienke S Weiss, Elena Kostova, Marleen Nahuis, Ben Willem J Mol, Fulco van der Veen, Madelon van Wely
BACKGROUND: Ovulation induction with follicle stimulating hormone (FSH) is a second-line treatment in women with polycystic ovary syndrome (PCOS) who do not ovulate or conceive on clomiphene citrate. OBJECTIVES: To compare the effectiveness and safety of gonadotrophins as a second-line treatment for ovulation induction in women with clomiphene citrate-resistant polycystic ovary syndrome (PCOS), and women who do not ovulate or conceive after clomiphene citrate. SEARCH METHODS: In January 2018, we searched the Cochrane Gynaecology and Fertility Group Specialised Register of Controlled Trials, CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL, the World Health Organisation clinical trials register, Clinicaltrials...
January 16, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30634990/prediction-of-the-lower-serum-anti-m%C3%A3-llerian-hormone-threshold-for-ovarian-stimulation-prior-to-in-vitro-fertilization-using-the-elecsys%C3%A2-amh-assay-a-prospective-observational-study
#29
JOURNAL ARTICLE
A G Grynnerup, K Løssl, F Pilsgaard, S A Lunding, M Storgaard, J W Bogstad, L Prætorius, A Zedeler, L Bungum, A Nyboe Andersen, A Pinborg
BACKGROUND: In assisted reproductive technology, prediction of treatment failure remains a great challenge. The development of more sensitive assays for measuring anti-Müllerian hormone (AMH) has allowed for the possibility to investigate if a lower threshold of AMH can be established predicting very limited or no response to maximal ovarian stimulation. METHODS: A prospective observational multicenter study of 107 women, < 40 years of age with regular menstrual cycle and serum AMH levels ≤ 12 pmol/L, treated with 300 IU/day of HP-hMG in a GnRH-antagonist protocol...
January 11, 2019: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/30428403/ovarian-stimulation-with-corifollitropin-alfa-followed-by-hp-hmg-compared-to-hp-hmg-in-patients-at-risk-of-poor-ovarian-response-undergoing-icsi-a-randomized-controlled-trial
#30
COMPARATIVE STUDY
Roser Taronger, Susana Martínez-Cuenca, Inmaculada Ferreros, José M Rubio, Pedro J Fernández-Colom, M Luisa Martínez-Triguero, Antonio Pellicer
OBJECTIVE: To compare the results of two ovarian stimulation protocols for IVF in patients at risk of poor ovarian response: corifollitropin alfa followed by hp-hMG versus daily administration of hp-hMG. We intended to demonstrate the non-inferiority of the protocol with corifollitropin alfa. STUDY DESIGN: This is a prospective, randomized, non-inferiority, controlled study. We compared two ovarian stimulation protocols for IVF in 234 patients, under 40 years of age and at risk of poor ovarian response...
December 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/30219283/conventional-versus-minimal-ovarian-stimulation-an-intra-patient-comparison-of-ovarian-response-in-poor-responder-women-according-to-bologna-criteria
#31
JOURNAL ARTICLE
Elena Labarta, Diego Marin, José Remohí, Ernesto Bosch
RESEARCH QUESTION: Is minimal ovarian stimulation (MOS) as effective as conventional ovarian stimulation (COS) in ovarian response and embryo quality in the same 46 poor-responder patients according to the Bologna criteria? DESIGN: An intra-patient comparison of patients undergoing both protocols. Ovaries were stimulated with either a gonadotrophin-releasing hormone antagonist protocol and a combination of recombinant FSH and highly purified human menotrophin (HP-HMG) daily (COS), or with the use of clomiphene citrate 50 mg daily and 150 IU of HP-HMG or recombinant FSH every other day from simulation day 4 (MOS)...
October 2018: Reproductive Biomedicine Online
https://read.qxmd.com/read/30129813/a-pilot-study-comparing-corifollitropin-alfa-associated-with-hp-hmg-versus-high-dose-rfsh-antagonist-protocols-for-ovarian-stimulation-in-poor-responders
#32
JOURNAL ARTICLE
Stéphanie Mendret-Pellerin, Florence Leperlier, Arnaud Reignier, Tiphaine Lefebvre, Paul Barrière, Thomas Fréour
Does corifollitropin alfa associated with hp-HMG protocol from the beginning of ovarian stimulation perform better than high dose rFSH alone for ovarian stimulation with GnRH antagonist in poor responders? This retrospective, monocentric, case-control pilot study was conducted in 65 poor responders (Bologna criteria) undergoing 2 consecutive IVF cycles. All patients underwent a first ovarian stimulation cycle with high dose rFSH (≥300 IU/day) alone in antagonist protocol, unfortunately leading to poor ovarian response and no pregnancy...
June 2020: Human Fertility: Journal of the British Fertility Society
https://read.qxmd.com/read/30021630/probabilistic-cost-effectiveness-analysis-of-controlled-ovarian-stimulation-with-recombinant-fsh-plus-recombinant-lh-vs-human-menopausal-gonadotropin-for-women-undergoing-ivf
#33
JOURNAL ARTICLE
F S Mennini, A Marcellusi, R Viti, C Bini, A Carosso, A Revelli, C Benedetto
BACKGROUND: The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular developments in human IVF. The aim of this analysis was to estimate the cost-effectiveness of Controlled Ovarian Stimulation (COS) with recombinant FSH (rFSH) plus recombinant LH (rLH) in comparison with highly purified human menopausal gonadotropin (HP-hMG) in the woman undergoing in vitro fertilization (IVF) in Italy...
July 18, 2018: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/29345163/low-dose-hp-hmg-in-an-antagonist-protocol-for-ivf-in-ovulatory-and-anovulatory-patients-with-high-amh
#34
JOURNAL ARTICLE
Negjyp Sopa, Elisabeth Clare Larsen, Anders Nyboe Andersen
Women with high-AMH levels have an increased risk of ovarian hyperstimulation syndrome (OHSS). Studies have suggested that highly purified menotropin (HP-hMG) Menopur® reduces the risk. We, therefore, studied use of low-dose (112.5 IU/day) HP-hMG in ovulatory and anovulatory patients with high AMH (>32 pmol/L). The primary endpoint was the distribution of patients with appropriate, excessive, and inadequate response (5-14, ≥15, and ≤4 oocytes). Another endpoint was frequency of OHSS. Totally 115 women were included and 78 (67...
July 2018: Gynecological Endocrinology
https://read.qxmd.com/read/29233501/does-ovarian-stimulation-regimen-affect-ivf-outcome-a-two-centre-real-world-retrospective-study-using-predominantly-cleavage-stage-single-embryo-transfer
#35
MULTICENTER STUDY
Per-Olof Karlström, Jan Holte, Nermin Hadziosmanovic, Kenny A Rodriguez-Wallberg, Jan I Olofsson
In this study, ovarian stimulation using highly purified human menopausal gonadotrophin (HP-HMG) and recombinant FSH (rFSH) for IVF were compared in two large assisted reproduction technique centres in Sweden. A total of 5902 women underwent 9631 oocyte retrievals leading to 8818 embryo transfers (7720 on day 2): single embryo transfers (74.2%); birth rate per embryo transfer (27.7%); multiple birth rate (5.0%); incidence of severe ovarian hyperstimulation syndrome (0.71%). Compared with ovarian stimulation with rFSH, women who received HP-HMG were older, had higher dosages of gonadotrophins administered, fewer oocytes retrieved and more embryos transferred...
January 2018: Reproductive Biomedicine Online
https://read.qxmd.com/read/29124676/cost-effectiveness-analysis-of-the-gonadotropin-treatments-hp-hmg-and-rfsh-for-assisted-reproductive-technology-in-france-a-markov-model-analysis
#36
JOURNAL ARTICLE
Paul Barriere, Géraldine Porcu-Buisson, Samir Hamamah
OBJECTIVES: The objectives of this study were to assess (1) the expected cost of a live birth (LB) after in vitro fertilization with two different gonadotropin treatments [high purified human menopausal gonadotropin (HP-hMG) and recombinant follicle-stimulating hormone (rFSH)] as the single cost variable, and (2) the cost effectiveness of HP-hMG relative to rFSH in the context of the routine practice of assisted reproductive technology (ART) in France. METHODS: A Markov model was developed to simulate the therapeutic management, the in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) courses, and the effects of complications in hypothetical cohorts of 30,000 patients undergoing IVF/ICSI with fresh embryo transfer (up to four attempts) using data from the MERIT and MEGASET clinical trials or from French routine ART practice...
February 2018: Applied Health Economics and Health Policy
https://read.qxmd.com/read/29040589/corifollitropin-alfa-followed-by-highly-purified-hmg-versus-recombinant-fsh-in-young-poor-ovarian-responders-a-multicentre-randomized-controlled-clinical-trial
#37
RANDOMIZED CONTROLLED TRIAL
Panagiotis Drakopoulos, Thi Ngoc Lan Vuong, Ngoc Anh Vu Ho, Alberto Vaiarelli, Manh Tuong Ho, Christophe Blockeel, Michel Camus, Anh Tuan Lam, Arne van de Vijver, Peter Humaidan, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: Does administration of corifollitropin alfa followed by highly purified (hp) HMG result in higher ongoing pregnancy rates compared with daily recombinant FSH (rFSH) in young poor responders? SUMMARY ANSWER: Corifollitropin alfa followed by hp-HMG does not increase ongoing pregnancy rates compared with rFSH in young poor responders, although more supernumerary cryopreserved embryos were obtained with corifollitropin alfa and hp-HMG. WHAT IS KNOWN ALREADY: Poor ovarian response remains one of the main therapeutic challenges in women undergoing ovarian stimulation, given that very low live birth rates of 6% have been reported in this particular group of infertile patients...
November 1, 2017: Human Reproduction
https://read.qxmd.com/read/28938744/an-improved-ivm-method-for-cumulus-oocyte-complexes-from-small-follicles-in-polycystic-ovary-syndrome-patients-enhances-oocyte-competence-and-embryo-yield
#38
JOURNAL ARTICLE
F Sánchez, F Lolicato, S Romero, M De Vos, H Van Ranst, G Verheyen, E Anckaert, J E J Smitz
STUDY QUESTION: Are meiotic and developmental competence of human oocytes from small (2-8 mm) antral follicles improved by applying an optimized IVM method involving a prematuration step in presence of C-Type Natriuretic Peptide (CNP) followed by a maturation step in presence of FSH and Amphiregulin (AREG)? SUMMARY ANSWER: A strategy involving prematuration culture (PMC) in the presence of CNP followed by IVM using FSH + AREG increases oocyte maturation potential leading to a higher availability of Day 3 embryos and good-quality blastocysts for single embryo transfer...
October 1, 2017: Human Reproduction
https://read.qxmd.com/read/28609269/corifollitropin-alfa-compared-to-daily-rfsh-or-hp-hmg-in-gnrh-antagonist-controlled-ovarian-stimulation-protocol-for-patients-undergoing-assisted-reproduction
#39
JOURNAL ARTICLE
Priscila Morais Galvão Souza, Bruno Ramalho de Carvalho, Hitomi Miura Nakagawa, Thalita Reis Esselin Rassi, Antônio César Paes Barbosa, Adelino Amaral Silva
OBJECTIVE: This study aimed to compare the outcomes of controlled ovarian stimulation (COS) with corifollitropin alfa versus daily recombinant follicle-stimulating hormone (rRFSH) or highly purified human menopausal gonadotropin (HP-HMG) in patients undergoing in vitro fertilization (IVF) cycles based on gonadotropin-releasing hormone (GnRH) antagonist protocols. The primary endpoints were total number of oocytes and mature oocytes. METHODS: This retrospective study looked into 132 controlled ovarian stimulation cycles from IVF or oocyte cryopreservation performed in a private human reproduction center between January 1 and December 31, 2014...
June 1, 2017: JBRA Assisted Reproduction
https://read.qxmd.com/read/28461237/-ovarian-hyperstimulation-syndrome-after-stimulation-with-highly-purified-hmgfor-in-vitro-fertilization-observational-study-shoview
#40
MULTICENTER STUDY
P Barrière, D Dewailly, A Duhamel, V Gayet
OBJECTIVE: Data on the incidence and severity of ovarian hyperstimulation syndrome (OHSS) in France are limited. METHODS: Prospective observational multicentric study (23 French centers of IVF) in a cohort of 421 women treated with highly purified hMG (HP-hMG) for the first or second cycle of IVF with or without ICSI. The primary objective was to assess the incidence of moderate to severe OHSS in this cohort. RESULTS: At inclusion, 172 patients (40...
May 2017: Gynecologie, Obstetrique, Fertilite & Senologie
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