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tibia fractures

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https://www.readbyqxmd.com/read/29770583/angle-stable-interlocking-intramedullary-nails-for-tibial-plateau-fractures
#1
Peng Jia, Feng-Cheng Lu, Kifayat Ullah, Man Zhang, Yan-Sheng Dong, Chao Xiong, Zhi-Hui Zhao, Jin-Feng Wang, Ju-Wen Chen, Yong-Qing Wang
OBJECTIVE: Angle stable interlocking intramedullary nail (ASIN), a novel technique, has rarely been used for treatment of tibial plateau fractures (TPF). This retrospective study was designed to introduce this novel technique, ASIN, as well as to describe the initial experience and verify the effectiveness when ASIN was used for the management for TPF. METHODS: A cohort of 19 cases with closed TPF aged from 18-70 years with at least 23 months follow-up from November 2008 to September 2013 was analyzed retrospectively...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29769819/structural-and-biomechanical-adaptations-to-free-fall-landing-in-hindlimb-cortical-bone-of-growing-female-rats
#2
Hsin-Shih Lin, Ho-Seng Wang, Hung-Ta Chiu, Kuang-You B Cheng, Ar-Tyan Hsu, Tsang-Hai Huang
The purpose of the study was to investigate the adaptation process of hindlimb cortical bone subjected to free-fall landing training. Female Wistar rats (7 weeks old) were randomly assigned to four landing (L) groups and four age-matched control (C) groups (n = 12 per group): L1, L2, L4 L8, C1, C2, C4 and C8. Animals in the L1, L2, L4 and L8 groups were respectively subjected to 1, 2, 4 and 8 weeks of free-fall-landing training (40 cm height, 30 times/day and 5 days/week) while the C1, C2, C4 and C8 groups served as age-matched control groups...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29762846/neurotrophin-3-improves-fracture-healing-in-rats
#3
X Li, D-C Sun, Y Li, X-Y Wu
OBJECTIVE: This study aimed at investigating the role of Neurotrophin-3 (NT-3) in the bone fracture healing of rats and to provide a reference for clinical treatment. MATERIALS AND METHODS: 40 Sprague-Dawley (SD) rats were randomly divided into control group and NT-3 group. The tibia fracture model was made in NT-3 group, and the tibia bone mineral density (BMD) was measured before and after the surgery. The biomechanics indexes were inspected after the surgery, including elasticity modulus, max load, and bending rigidity...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29762823/h19-promotes-the-proliferation-of-osteocytes-by-inhibiting-p53-during-fracture-healing
#4
Q-P Zhou, F Zhang, J Zhang, D Ma
OBJECTIVE: We explored the possible mechanism underlying the expression change of H19 during fracture healing. MATERIALS AND METHODS: A total of 18 male SD mice aged from 6-8 weeks old (18.5-24.6 g) were selected to establish tibial fracture models. The left tibia undergoing sham surgery was considered as the control group, and the right tibia undergoing sawing treatment was considered as the experimental group. The control tibia and fracture tibia from three mice were harvested at six time points after operation, respectively...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29758361/bone-accrual-in-oligo-amenorrheic-athletes-eumenorrheic-athletes-and-non-athletes
#5
Vibha Singhal, Karen Campoverde Reyes, Brooke Pfister, Kathryn Ackerman, Meghan Slattery, Katherine Cooper, Alexander Toth, Nupur Gupta, Mark Goldstein, Kamryn Eddy, Madhusmita Misra
BACKGROUND: Mechanical loading improves bone mineral density (BMD) and strength while decreasing fracture risk. Cross-sectional studies show that exercise advantage is lost in oligo-amenorrheic athletes (OA). Longitudinal studies examining the opposing effects of exercise and hypogonadism on bone are lacking in adolescents/young adults. OBJECTIVE: Evaluate differences in bone accrual over 12 months in OA, eumenorrheic athletes (EA) and non-athletes (NA). We hypothesized that bone accrual would be lower in OA than EA and NA, with differences most pronounced at non-weight bearing trabecular sites...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29751130/association-of-high-resolution-peripheral-quantitative-computed-tomography-hr-pqct-bone-microarchitectural-parameters-with-previous-clinical-fracture-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#6
Howard A Fink, Lisa Langsetmo, Tien N Vo, Eric S Orwoll, John T Schousboe, Kristine E Ensrud
High-resolution peripheral quantitative computed tomography (HR-pQCT) assesses both volumetric bone mineral density (vBMD) and trabecular and cortical microarchitecture. However, studies of the association of HR-pQCT parameters with fracture history have been small, predominantly limited to postmenopausal women, often performed limited adjustment for potential confounders including for BMD, and infrequently assessed strength or failure measures. We used data from the Osteoporotic Fractures in Men (MrOS) study, a prospective cohort study of community-dwelling men aged ≥65 years, to evaluate the association of distal radius, proximal (diaphyseal) tibia and distal tibia HR-pQCT parameters measured at the Year 14 (Y14) study visit with prior clinical fracture...
May 8, 2018: Bone
https://www.readbyqxmd.com/read/29750848/accelerated-bone-loss-in-older-men-effects-on-bone-microarchitecture-and-strength
#7
J A Cauley, A J Burghardt, S L Harrison, P M Cawthon, A V Schwartz, E Barrett Connor, Kristine E Ensrud, Lisa Langsetmo, S Majumdar, E Orwoll
Accelerated bone loss (ABL) shown on routine dual-energy X-ray absorptiometry (DXA) may be accompanied by microarchitectural changes, increased cortical porosity and lower bone strength. To test this hypothesis, we performed a cross-sectional study and used high resolution peripheral quantitative computed tomography (HR-pQCT) scans (SCANCO, Inc., Switzerland) to measure estimated bone strength and microarchitecture in the distal radius and distal and diaphyseal tibia. We studied 1628 men who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750829/robust-trabecular-microstructure-in-type-2-diabetes-revealed-by-individual-trabecula-segmentation-analysis-of-hr-pqct-images
#8
Jessica F Starr, Leonardo C Bandeira, Sanchita Agarwal, Ankit M Shah, Kyle K Nishiyama, Yizhong Hu, Donald J McMahon, X Edward Guo, Shonni J Silverberg, Mishaela R Rubin
Type 2 diabetes (T2D) patients have an increased fracture risk, which may be partly explained by compromised bone microarchitecture within the cortical bone compartment. Data on trabecular bone parameters in T2D are contradictory. By high resolution peripheral quantitative computed tomography (HR-pQCT) trabecular microarchitecture is preserved, yet larger trabecular holes are detected in T2D by MRI and DXA-based trabecular bone scores (TBS) are abnormal. To determine if there are differences in trabecular microstructure, connectivity and alignment in postmenopausal women with T2D as compared to controls, we performed individual trabecula segmentation (ITS) analysis on high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and tibia in 92 women with (n = 42) and without (n = 50) T2D...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29748140/bone-microarchitecture-of-the-tibial-plateau-in-skeletal-health-and-osteoporosis
#9
Matthias Krause, Jan Hubert, Simon Deymann, Alexander Hapfelmeier, Birgit Wulff, Andreas Petersik, Klaus Püschel, Michael Amling, Thelonius Hawellek, Karl-Heinz Frosch
BACKGROUND: Impaired bone structure poses a challenge for the treatment of osteoporotic tibial plateau fractures. As knowledge of region-specific structural bone alterations is a prerequisite to achieving successful long-term fixation, the aim of the current study was to characterize tibial plateau bone structure in patients with osteoporosis and the elderly. METHODS: Histomorphometric parameters were assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in 21 proximal tibiae from females with postmenopausal osteoporosis (mean age: 84...
May 7, 2018: Knee
https://www.readbyqxmd.com/read/29746363/lower-extremity-fractures-in-hospitalized-pediatric-patients-following-road-traffic-accidents
#10
Shay Tenenbaum, Jason T Bariteau, Ofir Chechik, Adi Givon, Kobi Peleg, Ran Thein
Lower extremity fractures (LEFs) caused by road traffic accidents (RTAs) can result in significant morbidity and account for a substantial part of nonfatal injuries requiring hospitalization. This study investigated the epidemiology of RTA-associated LEFs in the pediatric population. Based on the National Trauma Registry, data of 28,924 RTA hospitalized pediatric patients were reviewed. Data were analyzed according to LEF mechanism of injury, age distribution, fracture types, associated injuries, surgical treatment, and their interrelations...
May 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29737558/risk-of-injury-to-the-sural-nerve-during-posterolateral-approach-to-the-distal-tibia-an-ultrasound-simulation-study
#11
Ewa Mizia, Przemysław A Pękala, Piotr Chomicki-Bindas, Wojciech Marchewka, Marios Loukas, Alexander G Zayachkowski, Krzysztof A Tomaszewski
Introduction When surgeons operate on the foot and ankle, the most common complication that may arise is injury of the cutaneous nerves. The sural nerve (SN) is potentially at risk of being injured when treating fractures involving the distal tibia using the posterolateral approach. The aim of this study was to evaluate how differences in length and position of the surgical treatment of fractures involving the distal tibia can affect the risk of SN injury. Materials and Methods The study involved 40 healthy volunteers (n=80 lower limbs)...
May 8, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29737414/bone-geometry-in-young-male-and-female-football-players-a-peripheral-quantitative-computed-tomography-pqct-study
#12
Gabriel Lozano-Berges, Ángel Matute-Llorente, Alejandro Gómez-Bruton, Alex González-Agüero, Germán Vicente-Rodríguez, José A Casajús
The present study shows that football practice during growth may improve bone geometry in male and female football players. However, only females had better bone strength in comparison with controls. PURPOSE: The aim of this study was to compare bone geometry in adolescent football players and controls. METHODS: A total of 107 football players (71 males/36 females; mean age 12.7 ± 0.6/12.7 ± 0.6 years) and 42 controls (20 males/22 females; mean age 13...
May 8, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29737002/lower-limb-reconstruction-with-chimeric-flaps-the-quad-flap
#13
Solomon M Azouz, Nikki A Castel, Aparna Vijayasekaran, Alanna M Rebecca, Salvatore C Lettieri
Early soft-tissue coverage is critical for treating traumatic open lower-extremity wounds. As free-flap reconstruction evolves, injuries once thought to be nonreconstructable are being salvaged. Free-tissue transfer is imperative when there is extensive dead space or exposure of vital structures such as bone, tendon, nerves, or blood vessels. We describe 2 cases of lower-extremity crush injuries salvaged with the quad flap. This novel flap consists of parascapular, scapular, serratus, and latissimus dorsi free flaps in combination on one pedicle...
May 7, 2018: Microsurgery
https://www.readbyqxmd.com/read/29736882/a-challenging-case-of-tumor-induced-osteomalacia-pathophysiological-and-clinical-implications
#14
Luciano Colangelo, Cristiana Cipriani, Jessica Pepe, Alessandro Corsi, Chiara Sonato, Giulia Follacchio, Mirella Cilli, Walter Gianni, Federica Ferrone, Oreste Moreschini, Lorraine A Fitzpatrick, Salvatore Minisola
We investigated the usefulness of fibroblast growth factor 23 (FGF23) intraoperative assay to monitor tumor resection in patients with oncogenic osteomalacia. A 33-year-old man with 5 years' history of lumbar and pelvis pain together with multiple vertebral fractures was admitted to our hospital. He was diagnosed with ankylosing spondylitis 1 year before. Laboratory investigation showed low tubular reabsorption of phosphate (0.41 mmol/L) despite chronic hypophosphatemia (0.39/L). Increased plasma values of FGF23 (673 pg/mL; n...
May 7, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29735339/distal-medial-tibial-locking-plate-for-fixation-of-extraarticular-distal-humeral-fractures-an-alternative-choice-for-fixation
#15
Ali Cagdas Yorukoglu, Ahmet Fahir Demirkan, Nihal Buker
OBJECTIVE: The aim of this study was to describe an alternative fixation method for distal humeral extra-articular fractures through posterior approach using distal tibia anatomic locking plate; and to evaluate the patient's functional outcome and union condition. METHODS: Eighteen patients (11 men and 7 women; average age of 37.0 ± 17.3 years (range: 18-73 years)) with a distal humeral extra-articular fracture who were treated with distal tibial medial locking plate were included into the study...
May 4, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29730704/normal-bone-microstructure-and-density-but-worse-physical-function-in-older-women-treated-with-selective-serotonin-reuptake-inhibitors-a-cross-sectional-population-based-study
#16
Berit Larsson, Dan Mellström, Lisa Johansson, Anna G Nilsson, Mattias Lorentzon, Daniel Sundh
Depression in the elderly is today often treated with selective serotonin reuptake inhibitors (SSRIs) because of their favorable adverse effect profile. However, treatment with SSRIs is associated with increased risk of fractures. Whether this increased risk depends on reduced bone strength or increased fall risk due to reduced physical function is not certain. The aim was therefore to investigate if treatment with SSRIs is associated with impaired bone microstructure, bone density, or physical function in older women...
May 5, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29730277/regional-variation-of-bone-density-microarchitectural-parameters-and-elastic-moduli-in-the-ultradistal-tibia-of-young-black-and-white-men-and-women
#17
Ginu Unnikrishnan, Chun Xu, Kristin L Popp, Julie M Hughes, Amy Yuan, Katelyn I Guerriere, Signe Caksa, Kathryn E Ackerman, Mary L Bouxsein, Jaques Reifman
Whole-bone analyses can obscure regional heterogeneities in bone characteristics. Quantifying these heterogeneities might improve our understanding of the etiology of injuries, such as lower-extremity stress fractures. Here, we performed regional analyses of high-resolution peripheral quantitative computed tomography images of the ultradistal tibia in young, healthy subjects (age range, 18 to 30 years). We quantified bone characteristics across four regional sectors of the tibia for the following datasets: white women (n = 50), black women (n = 51), white men (n = 50), black men (n = 34), and all subjects (n = 185)...
May 3, 2018: Bone
https://www.readbyqxmd.com/read/29721763/optimization-of-a-closed-rat-tibial-fracture-model
#18
Kareem Obayes Handool, Sahar Mohammed Ibrahim, Ubedullah Kaka, Muhammad Aarif Omar, Jalila Abu, Md Sabri Mohd Yusoff, Loqman Mohamad Yusof
BACKGROUND: The use of a closed fracture model has become the preferred model to study the fracture healing process, given that the periosteum and the soft tissue surrounding the fracture site play an important role in the fracture healing process. Some techniques like osteotomy, drilling the long bones and the use of the guillotine-like apparatus to induce fracture are characterized by some undesirable effects and complications. The aim of this study is to optimize and evaluate an in vivo fracture model using three-point bending pliers that can be used to study secondary bone fracture healing in rats...
May 2, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29720540/porcupine-inhibitors-impair-trabecular-and-cortical-bone-mass-and-strength-in-mice
#19
Thomas Funck-Brentano, Karin H Nilsson, Robert Brommage, Petra Henning, Ulf H Lerner, Antti Koskela, Juha Tuukkanen, Martine Cohen-Solal, Sofia Movérare-Skrtic, Claes Ohlsson
WNT signalling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health are unknown, we determined their effects on bone mass and strength. Twelve-week-old C57BL/6N female mice were treated by the Porcupine inhibitors LGK974 (Low dose = 3 mg/kg/day; High dose = 6 mg/kg/day) or Wnt-C59 (10 mg/kg/day) or vehicle for three weeks...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29715519/oxidative-stress-contributes-to-fracture-cast-induced-inflammation-and-pain-in-a-rat-model-of-complex-regional-pain-syndrome
#20
Tian-Zhi Guo, Tzuping Wei, Ting-Ting Huang, Wade S Kingery, John David Clark
Clinical evidence suggests vitamin C (Vit C) may protect against the development of complex regional pain syndrome (CRPS) after fracture and/or surgery. Tibia fracture followed by 4 weeks cast immobilization (fracture/cast) in rats results in nociceptive, vascular, and bone changes resembling clinical CRPS. In the present study, fracture/cast rats were treated with the oxidative stress inhibitors Vit C, N-acetyl cysteine (NAC) or 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) to examine their effects on CRPS-related nociceptive and vascular changes...
April 28, 2018: Journal of Pain: Official Journal of the American Pain Society
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