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1q21 multiple myeloma

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https://www.readbyqxmd.com/read/27694925/hyperhaploidy-is-a-novel-high-risk-cytogenetic-subgroup-in-multiple-myeloma
#1
J R Sawyer, E Tian, J D Shaughnessy, J Epstein, C M Swanson, C Stangeby, C L Hale, L Parr, M Lynn, G Sammartino, J L Lukacs, C Stein, C Bailey, M Zangari, F E Davies, F Van Rhee, B Barlogie, G J Morgan
Hyperhaploid clones (24-34 chromosomes) were identified in 33 patients with multiple myeloma (MM), identifying a novel numerical cytogenetic subgroup. Strikingly, all hyperhaploid karyotypes were found to harbor monosomy 17p, the single most important risk stratification lesion in MM. A catastrophic loss of nearly a haploid set of chromosomes results in disomies of chromosomes 3,5,7,9,11,15,18,19, and 21, the same basic set of odd-numbered chromosomes found in trisomy in hyperdiploid myeloma. All other autosomes are found in monosomy, resulting in additional clinically relevant monosomies of 1p, 6q, 13q, and 16q...
October 3, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27662018/autotransplant-with-and-without-induction-chemotherapy-in-older-multiple-myeloma-patients-long-term-outcome-of-a-randomized-trial
#2
Christian Straka, Peter Liebisch, Hans Salwender, Burkhard Hennemann, Bernd Metzner, Stefan Knop, Sigrid Adler-Reichel, Christian Gerecke, Hannes Wandt, Martin Bentz, Tim Hendrik Bruemmendorf, Marcus Hentrich, Michael Pfreundschuh, Hans-Heinrich Wolf, Orhan Sezer, Ralf Bargou, Wolfram Jung, Lorenz Trümper, Bernd Hertenstein, Else Heidemann, Helga Bernhard, Nicola Lang, Norbert Frickhofen, Holger Hebart, Ralf Schmidmaier, Andreas Sandermann, Tobias Dechow, Albrecht Reichle, Brigitte Schnabel, Kerstin Schäfer-Eckart, Christian Langer, Martin Gramatzki, Axel Hinke, Bertold Emmerich, Hermann Einsele
Autologous transplantation is controversial for older patients with multiple myeloma. The role of age-adjusted high-dose melphalan and the impact of induction chemotherapy cycles is still unclear. A total of 434 patients aged 60-70 years were randomly assigned to 4 cycles of standard anthracycline-based induction chemotherapy or no induction. For all patients, double autologous transplantation after melphalan 140 mg/m(2) (MEL140) was planned. The primary end point was progression-free survival. Of 420 eligible patients, 85% received a first transplant and 69% completed double transplantation...
November 2016: Haematologica
https://www.readbyqxmd.com/read/27638366/outcome-of-patients-with-multiple-myeloma-and-cks1b-gene-amplification-after-autologous-hematopoietic-stem-cell-transplantation
#3
Fabian Bock, Gary Lu, Samer A Srour, Sameh Gaballa, Heather Y Lin, Veerabhadran Baladandayuthapani, Medhavi Honhar, Maximilian Stich, Nina Das Shah, Qaiser Bashir, Krina Patel, Uday Popat, Chitra Hosing, Martin Korbling, Ruby Delgado, Gabriela Rondon, Jatin J Shah, Sheeba K Thomas, Elisabet E Manasanch, Berend Isermann, Robert Z Orlowski, Richard E Champlin, Muzaffar H Qazilbash
The gain/amplification of the CKS1B gene on chromosome 1q21 region is associated with a poor outcome in patients with multiple myeloma (MM). However, there are limited data on the outcome of patients with CKS1B amplification after a single high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HCT). We retrospectively evaluated the outcome of patients with CKS1B amplification who received an auto-HCT between June 2012 and July 2014 at our institution. We identified 58 patients with MM and CKS1B gene amplification detected by fluorescent in situ hybridization (FISH)...
September 13, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27592569/-genetic-abnormality-in-101-cases-of-plasma-cell-dyscrasias-by-fish-technology-and-cytogenetic-examination
#4
Pengfei Cao, Guiyuan Li, Qian Tan, Ying Zhang, Guoping Zhang, Xiaolin Li, Yuxiang He
OBJECTIVE: To investigate several abnormal genes by the fluorescence in situ hybridization (FISH) in multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS) and reactive plasmacytosis (RP), and to increase the diagnosis and differential diagnosis levels for these common plasma diseases. 
 METHODS: The clinical manifestations, image and laboratory tests and the FISH detection were retrospectively analyzed in 61 cases of newly diagnosed MM, 20 cases of MGUS and 20 cases of RP from August, 2012 to February, 2015 in the Xiangya Hospital of Central South University...
July 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27590108/allogeneic-hematopoietic-cell-transplantation-in-multiple-myeloma-focus-on-longitudinal-assessment-of-donor-chimerism-extramedullary-disease-and-high-risk-cytogenetic-features
#5
Leo Rasche, Christoph Röllig, Gernot Stuhler, Sophia Danhof, Stephan Mielke, Goetz Ulrich Grigoleit, Lea Dissen, Lea Schemmel, Jan Moritz Middeke, Viktoria Rücker, Martin Schreder, Johannes Schetelig, Martin Bornhäuser, Hermann Einsele, Christian Thiede, Stefan Knop
Although generally not applied as first-line treatment of multiple myeloma, allogeneic hematopoietic cell transplantation (allo-SCT) can still be chosen as ultimate escalation approach in high-risk patients, preferentially within the framework of clinical trials. In this study, we investigated whether decreasing donor chimerism (DC) is predictive for relapse. In addition, we comprehensively determined the impact of several other disease- and treatment-related factors on outcome. One hundred fifty-five multiple myeloma patients whose DC status was followed serially by the short tandem repeat-based techniques at a single lab were included in this retrospective study...
November 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27531777/-expression-of-cd56-and-cd19-in-patients-with-newly-diagnosed-multiple-myeloma-and-their-relationship-with-karyotypes-and-prognosis
#6
Quan Qiu, Ping Zhu, Mang-Ju Wang, Xu-Zhen Lu, Yu-Jun Dong, Yu-Hua Sun, Li-Hong Wang, Ying Zhang, Ding-Fang Bu, Wen-Sheng Wang, Ze-Yin Liang, Wei Liu, Zhi-Xiang Qiu, Jin-Ping Ou, Xi-Nan Cen
OBJECTIVE: To study the relationship between surface markers of CD56 and CD19 and karyotypes and prognosis in multiple myeloma. METHODS: A total of 126 cases of newly diagnosed multiple myeloma in the first hospital of Peking university from 2011 to 2015 were enrolled in this study. Cytogenetic abnormalities and immunophenotypes were detected by using fluorescence in situ hybridization and flow cytometry respectively before chemotherapy. Bone marrow smear was used for detection of abnormal plasma cell infiltration...
August 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27257181/prognostic-impact-of-cytogenetic-aberrations-in-al-amyloidosis-patients-after-high-dose-melphalan-a-long-term-follow-up-study
#7
Tilmann Bochtler, Ute Hegenbart, Christina Kunz, Axel Benner, Christoph Kimmich, Anja Seckinger, Dirk Hose, Hartmut Goldschmidt, Martin Granzow, Peter Dreger, Anthony D Ho, Anna Jauch, Stefan O Schönland
Cytogenetic aberrations detected by interphase fluorescence in situ hybridization (iFISH) of plasma cells are routinely evaluated as prognostic markers in multiple myeloma. This long-term follow-up study aimed to assess the prognosis of systemic light chain amyloidosis (AL) patients treated with high-dose melphalan (HDM) chemotherapy and autologous stem cell transplantation, depending on iFISH results. Therefore, we analyzed a consecutive cohort of 123 AL patients recruited from 2003 to 2014. HDM was safe, with only 1 of 123 patients dying as a result of treatment-related mortality, and effective, with a complete remission (CR) rate of 34%...
July 28, 2016: Blood
https://www.readbyqxmd.com/read/27175647/prognostic-impact-of-cytogenetic-abnormalities-in-multiple-myeloma-a-retrospective-analysis-of-229-patients
#8
Yuan Jian, Xiaolei Chen, Huixing Zhou, Wanqiu Zhu, Nian Liu, Chuanying Geng, Wenming Chen
The identification of specific cytogenetic abnormalities by interphase fluorescence in situ hybridization (i-FISH) has become a routine procedure for prognostic stratification of multiple myeloma (MM) patients. In this study, the prognostic significance of cytogenetic abnormalities detected by interphase fluorescence in situ hybridization (iFISH) in 229 newly diagnosed multiple myeloma patients was retrospectively analyzed. Results showed that del (17p), t(4;14), and 1q21 gain were adverse predictors of progression-free survival (PFS)...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27129167/potential-role-of-exosome-associated-microrna-panels-and-in-vivo-environment-to-predict-drug-resistance-for-patients-with-multiple-myeloma
#9
Li Zhang, Ling Pan, Bing Xiang, Huanling Zhu, Yu Wu, Meng Chen, Pujun Guan, Xingli Zou, C Alexander Valencia, Biao Dong, Jianjun Li, Liping Xie, Hongbing Ma, Fangfang Wang, Tian Dong, Xiao Shuai, Ting Niu, Ting Liu
Multiple myeloma (MM) is the second most common hematologic neoplasms and an appropriate in vivo environment for myeloma cells has potential implications for initiation, progression, and metastasis of MM. Exosomes, entities carrying microRNAs (miRNAs) to target locations, participate in the cross-talk between myeloma cells and nonmalignant components of the in vivo environment. This study disclosed the emerging roles of circulating exosome-associated miRNAs in drug resistance (DR) of MM. To this end, the medical records of consecutively hospitalized MM patients, who received novel agents-based therapies, were analyzed...
May 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27101987/cytogenetics-and-survival-of-multiple-myeloma-isolated-and-combined-effects
#10
Theodoros N Sergentanis, Efstathios Kastritis, Evangelos Terpos, Meletios A Dimopoulos, Theodora Psaltopoulou
BACKGROUND: A variety of clinical and laboratory prognostic factors for multiple myeloma (MM) have been addressed in published studies. The prognostic significance of cytogenetic abnormalities is also under investigation. PATIENTS AND METHODS: The present study evaluated the potential prognostic role of cytogenetic events and their combinations in terms of overall survival in a large cohort of unselected patients with MM (n = 432). Multivariate Cox regression analysis was performed, adjusting for age, gender, Chronic Kidney Disease Epidemiology Collaboration Kidney Disease: Improving Global Outcomes classification, International Staging System score, Eastern Cooperative Oncology Group performance status, serum lactate dehydrogenase, serum calcium, platelet count, and blood hemoglobin...
June 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27042105/cytogenetic-abnormality-in-patients-with-multiple-myeloma-analyzed-by-fluorescent-in-situ-hybridization
#11
Ying Hu, Wenming Chen, Shilun Chen, Zhongxia Huang
OBJECTIVE: To analyze the fluorescent in situ hybridization (FISH) data and the association with clinical characteristics, therapy response, and survival time in patients with multiple myeloma. METHOD: We performed a retrospective review of patients with multiple myeloma from November 2010 to April 2014. RESULTS: Cytogenetic abnormalities by FISH were detectable in 66% of patients. One cytogenetic abnormality, two cytogenetic abnormalities, and complex abnormalities were detectable in 21...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26932854/-clinical-and-biological-characteristics-multiple-myeloma-with-1q21-amplification
#12
Shizhen Zhong, Chengwen Li, Shihua Yi, Lugui Qiu
OBJECTIVE: To study the clinical features of multiple myeloma (MM) patients with 1q21 amplification and the detection and biological characteristics of 1q21 copy number variation among different stages of plasma cell dyscrasias. METHODS: We analyzed the amplification and copy number variation of 1q21 in a cohort of 397 MM patients (290 newly diagnosed patients and 107 relapsed/refractory patients) in Institute of Hematology and Blood Diseases Hospital in the period between January 2009 and December 2012, using fluorescence in situ hybridization (FISH)...
March 1, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26913408/-cytogenetic-abnormalities-and-outcomes-of-117-patients-with-multiple-myeloma-detected-by-fish
#13
Bing Zhai, Dan-Dan Zou, Jian-Jun Yan, Nan Wang, Li-Li Wang, Hong-Li Zhu, Wen-Rong Huang, Li Yu
OBJECTIVE: To analyze the cytogenetic abnormalities and prognostic outcomes of patients with multiple myeloma (MM) detected by fluorescence in situ hybridization (FISH). METHODS: The clinical record of 117 newly-diagnosed patients with MM treated in department of hematology and geriatric hematology of our hospital for 7 years were collected, and their molecular cytogenetic abnormalities detected by FISH and the clinical outcome were analyzed retrospectively. RESULTS: The detected rate of cytogenetic abnormality was 76...
February 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26834489/the-amplification-of-1q21-is-an-adverse-prognostic-factor-in-patients-with-multiple-myeloma-in-a-chinese-population
#14
Wenjun Yu, Rui Guo, Xiaoyan Qu, Hairong Qiu, Jianyong Li, Run Zhang, Lijuan Chen
The prognostic heterogeneity of multiple myeloma (MM) is largely due to different genetic abnormalities. Cytogenetic analysis has revealed that most of MM harbor chromosome aberrations. Amplification of 1q21 is one of the most common chromosomal aberrations. Interphase fluorescence in situ hybridization was applied to detect the 1q21 amplification in 86 Chinese patients with newly diagnosed MM. Amp(1q21) was found in totally 40 of 86 (46.5%) cases, among which 29 with three copies of 1q21 and eleven with at least four copies of 1q21...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26611471/concomitant-gain-of-1q21-and-myc-translocation-define-a-poor-prognostic-subgroup-of-hyperdiploid-multiple-myeloma
#15
LETTER
Niels Weinhold, Desiree Kirn, Anja Seckinger, Thomas Hielscher, Martin Granzow, Uta Bertsch, Gerlinde Egerer, Hans Salwender, Igor W Blau, Katja Weisel, Jens Hillengass, Marc S Raab, Dirk Hose, Hartmut Goldschmidt, Anna Jauch
No abstract text is available yet for this article.
March 2016: Haematologica
https://www.readbyqxmd.com/read/26524071/-abnormal-karyotypes-involving-1q21-and-12p13-and-their-clinical-significance
#16
REVIEW
Ru Jia, Wan-Ling Sun
Many hematological malignances involve recurrent chromosomal abnormalities, and the reciprocal translocation is one of them. However, there are a lot of chromosomal abnormalities with lower incidence and unclear clinical significance. Among them, the one abnormal karyotype translocation, t (1;12) (q21; p13) is a rare karyotype change. Only 6 patients had been reported to have this karyotype and all of them suffered from hematologic diseases, including one case of acute myeloid leukemia, one case of high-risk myelodysplastic syndrome, two children with acute lymphoblastic leukemia, one case of chronic myeloid leukemia at accelerated phase and one case of multiple myeloma...
October 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26524036/-detection-of-molecular-cytogenetic-aberrations-by-fluorescence-in-situ-hybridization-in-different-bone-marrow-samples-of-multiple-myeloma
#17
Yan-Fang Wang, Hua Wang, Lian-Yong Xi, Yan Liu, Fei Dong, Ji-Jun Wang, Xiao-Yan Ke
OBJECTIVE: To detect the molecular cytogenetic abnormalities in different bone marrow samples of multiple myeloma by using fluorescence in situ hybridization (FISH) technology. The bone marrow cells from 48 cases of MM were taken for sorting the plasma cells using CD138 magnetic beads, and the biopsy tissue from 10 cases of MM was taken and embedded in parafin, then the 2 kinds of samples were detected by using FISH. D13s319/RB1, 1q21/P53, IgH, IgH/FGFR3, IgH/MAF probes were detected in 58 patients with new diagnosed multiple myeloma (MM) by FISH technology...
October 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26524035/-influence-of-cd117-expression-on-response-of-multiple-myeloma-patients-to-chemotherapy
#18
Hai-Long Tang, Mi-Mi Shu, Bao-Xia Dong, Hong-Tao Gu, Rong Liang, Qing-Xian Bai, Lan Yang, Tao Zhang, Guang-Xun Gao, Xie-Qun Chen
OBJECTIVE: To investigate the influence of CD117 expression on response of multiple myeloma patients to chemo-therapy. METHODS: A total of 65 cases of newly diagnosed multiple myeloma in our hospital from 2011 to 2013 were enrolled in this study. Cytogenetic abnormalities and immunophenotype were detected by using fluorescence in situ hybridization and flow cytometry before chemotherapy. The therapeutic efficacy of patients was evaluated after 4 cycles of PAD or TAD regimen...
October 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26516702/microrna-15a-16-1-cluster-located-at-chromosome-13q14-is-down-regulated-but-displays-different-expression-pattern-and-prognostic-significance-in-multiple-myeloma
#19
Fei Li, Yan Xu, Shuhui Deng, Zengjun Li, Dehui Zou, Shuhua Yi, Weiwei Sui, Mu Hao, Lugui Qiu
MiRNA-15a/16-1 cluster located at chromosome 13q14 has been confirmed to regulate critical genes associated with cell proliferation, apoptosis and drug resistance in multiple myeloma (MM). However, little is known about their expression pattern and prognostic value in MM patients. In this study, we have analyzed the expression levels of miR-15a/16-1 in 117 MM patients (90 newly diagnosed, 11 relapsed and 16 remission patients) and 19 health donors (HDs) by quantitative real-time PCR. Our results indicated that the expression levels of miR-15a and 16-1 were down-regulated in newly diagnosed MM patients as compared to HDs (P = 0...
November 10, 2015: Oncotarget
https://www.readbyqxmd.com/read/26513019/uchl1-is-a-biomarker-of-aggressive-multiple-myeloma-required-for-disease-progression
#20
Sajjad Hussain, Tibor Bedekovics, Marta Chesi, P Leif Bergsagel, Paul J Galardy
The success of proteasome inhibition in multiple myeloma highlights the critical role for the ubiquitin-proteasome system (UPS) in this disease. However, there has been little progress in finding more specific targets within the UPS involved in myeloma pathogenesis. We previously found the ubiquitin hydrolase UCH-L1 to be frequently over-expressed in B-cell malignancies, including myeloma, and showed it to be a potent oncogene in mice. Here we show that UCH-L1 is a poor prognostic factor that is essential for the progression of myeloma...
December 1, 2015: Oncotarget
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