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https://www.readbyqxmd.com/read/29665832/volumetric-and-dosimetric-comparison-of-organs-at-risk-between-the-prone-and-supine-positions-in-postoperative-radiotherapy-for-prostate-cancer
#1
Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe, Keiichi Nakagawa
BACKGROUND: The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radiotherapy for prostate cancer after prostatectomy. METHODS: Seventeen patients who received intensity-modulated radiation therapy (66 Gy in 33 fractions) as adjuvant or salvage therapy after prostatectomy were evaluated. All patients underwent CT scans in both the prone (on a belly board) and supine positions...
April 17, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29664243/new-technologies-and-techniques-for-prostate-cancer-focal-therapy-a-review-of-the-current-literature
#2
Estefanía Linares-Espinós, Arie Carneiro, Juan I Martínez-Salamanca, Fernando Bianco, Adalberto Castro-Alfaro, Xavier Cathelineau, Massimo Valerio, Rafael Sanchez-Salas
BACKGROUND: The aim of this study was to review the oncological and functional outcomes of new and established primary focal treatments (FT) for localized prostate cancer (PCa). METHODS: We performed a systematic search of published studies on FT for localized PCa using electronic databases (Medline and Embase). These studies included reports on hemiablation, focal ablation and target-ablation. We excluded salvage focal therapy studies and limited the search to those with a minimum of 12 months of follow-up...
April 16, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29642326/re-robotic-salvage-retroperitoneal-and-pelvic-lymph-node-dissection-for-node-only-recurrent-prostate-cancer-technique-and-initial-series
#3
Jeffrey A Cadeddu
No abstract text is available yet for this article.
April 2018: Journal of Urology
https://www.readbyqxmd.com/read/29625782/lymph-node-yield-during-radical-prostatectomy-does-not-impact-rate-of-biochemical-recurrence-in-patients-with-seminal-vesicle-invasion-and-node-negative-disease
#4
Ketan K Badani, Balaji N Reddy, Eric J Moskowitz, David J Paulucci, Alp Tuna Beksac, Alberto Martini, Michael J Whalen, Douglas W Skarecky, Linda My Huynh, Thomas E Ahlering
OBJECTIVES: Seminal vesicle invasion (SVI) is a risk factor for poor oncologic outcome in patients with prostate cancer. Modifications to the pelvic lymph node dissection (PLND) during radical prostatectomy (RP) have been reported to have a therapeutic benefit. The present study is the first to determine if lymph node yield (LNY) is associated with a lower risk of biochemical recurrence (BCR) for men with SVI. METHODS: A total of 220 patients from 2 high-volume institutions who underwent RP without adjuvant treatment between 1990 and 2015 and had prostate cancer with SVI (i...
April 3, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29625755/-99m-technetium-based-prostate-specific-membrane-antigen-radioguided-surgery-in-recurrent-prostate-cancer
#5
Tobias Maurer, Stephanie Robu, Margret Schottelius, Kristina Schwamborn, Isabel Rauscher, Nynke S van den Berg, Fijs W B van Leeuwen, Bernhard Haller, Thomas Horn, Matthias M Heck, Jürgen E Gschwend, Markus Schwaiger, Hans-Jürgen Wester, Matthias Eiber
BACKGROUND: Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) can visualize metastatic lesions in recurrent prostate cancer (PC). However, reliable identification of small and/or atypically localized lesions during salvage surgery procedures is challenging. OBJECTIVE: To describe the technique, feasibility, and short-term outcomes of99m Technetium (99m Tc)-based PSMA-radioguided surgery (99m Tc-PSMA-RGS) for removal of recurrent PC lesions...
April 3, 2018: European Urology
https://www.readbyqxmd.com/read/29616296/psma-pet-guided-hook-wire-localization-of-nodal-metastases-in-prostate-cancer-a-targeted-approach
#6
REVIEW
Emma Clarebrough, Catriona Duncan, Daniel Christidis, Alain Lavoipierre, Nathan Lawrentschuk
Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (PSMA-PET/CT) has increased the sensitivity and specificity of imaging to identify metastatic prostate cancer in the group of patients with early biochemical recurrence when compared to conventional imaging. In patients who develop biochemical recurrence of prostate cancer following surgical resection, salvage lymph node dissection may reduce prostate specific antigen (PSA) levels and delay the time for commencement of systemic therapies...
April 3, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29603326/the-impact-of-intraductal-carcinoma-of-the-prostate-on-the-site-and-timing-of-recurrence-and-cancer-specific-survival
#7
Vincent Q Trinh, Jennifer Sirois, Nazim Benzerdjeb, Babak K Mansoori, Andrée-Anne Grosset, Roula Albadine, Mathieu Latour, Anne-Marie Mes-Masson, Hélène Hovington, Alain Bergeron, Martin Ladouceur, Yves Fradet, Fred Saad, Dominique Trudel
BACKGROUND: To investigate the effect of intraductal carcinoma of the prostate (IDC-P) in radical prostatectomy (RP) specimens in the context of the site of recurrence, time to recurrence, and cancer-specific survival in two academic cohorts of locally, regionally, or distantly recurrent prostate cancer. METHODS: Our cohort included men enrolled into two academic tissue repositories from 1993 to 2011, who were treated with first-line RP who later experienced local recurrence, regional recurrence, or distant metastasis (together termed clinical recurrence, CR)...
March 30, 2018: Prostate
https://www.readbyqxmd.com/read/29588854/experimental-study-of-beam-distortion-due-to-fiducial-markers-during-salvage-hifu-in-the-prostate
#8
Marina Bakaric, Eleanor Martin, Panayiotis S Georgiou, Benjamin T Cox, Heather Payne, Bradley E Treeby
Background: Prostate cancer is frequently treated using external beam radiation therapy (EBRT). Prior to therapy, the prostate is commonly implanted with a small number of permanent fiducial markers used to monitor the position of the prostate during therapy. In the case of local cancer recurrence, high-intensity focused ultrasound (HIFU) provides a non-invasive salvage treatment option. However, the impact of the fiducial markers on HIFU treatment has not been thoroughly studied to date...
2018: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29588072/dose-escalation-for-prostate-stereotactic-ablative-radiotherapy-sabr-late-outcomes-from-two-prospective-clinical-trials
#9
Yasir Alayed, Patrick Cheung, Geordi Pang, Alexandre Mamedov, Laura D'Alimonte, Andrea Deabreu, Kristina Commisso, Angela Commisso, Liang Zhang, Harvey C Quon, Hima Bindu Musunuru, Joelle Helou, D Andrew Loblaw
PURPOSE: Optimal prostate SABR dose-fractionation is unknown. This study compares long-term outcomes from two prospective trials. METHODS: Study1 patients had low-risk PCa and received 35 Gy/5. Study2 patients had low/intermediate-risk PCa and received 40 Gy/5. Biochemical failure (BF) was defined as nadir + 2. RESULTS: 114 patients were included (study1, n = 84; study2, n = 30). Median follow-up was 9.6 years and 6.9 years...
March 24, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29577651/prostate-specific-antigen-nadir-within-12-months-as-an-early-surrogate-marker-of-biochemical-failure-and-distant-metastasis-after-low-dose-rate-brachytherapy-or-external-beam-radiotherapy-for-localized-prostate-cancer
#10
Shuichi Nishimura, Toshio Ohashi, Tetsuo Momma, Masanori Sakayori, Takahisa Eriguchi, Tomoki Tanaka, Shoji Yamashita, Takeo Kosaka, Mototsugu Oya, Naoyuki Shigematsu
Prostate-specific antigen nadir (nPSA) after radiotherapy for localized prostate cancer has been investigated as a predictor. However, nPSA usually requires several years, limiting its clinical utility. We investigated the significance of nPSA within 12 months (nPSA12) after low-dose-rate prostate brachytherapy (LDR-PB) or external beam radiotherapy (EBRT) on treatment outcomes. Between 2006 and 2014, 663 patients with prostate cancer were treated with LDR-PB or EBRT at two institutions. Four hundred and seventy-four men received LDR-PB and 189 men received EBRT, without androgen deprivation therapy...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29573193/importance-of-the-site-of-positive-surgical-margin-in-salvage-external-beam-radiation-therapy-for-biochemical-recurrence-of-prostate-cancer-after-radical-prostatectomy
#11
Tairo Kashihara, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Koji Inaba, Rei Umezawa, Satoshi Shima, Keisuke Tsuchida, Kazuma Kobayashi, Kana Takahashi, Naoya Murakami, Yoshinori Ito, Hiroshi Igaki, Hiroyuki Fujimoto, Takashi Uno, Jun Itami
The aim of this study was to examine long-term outcomes in patients who received salvage radiotherapy (SRT) for biochemical recurrence (BRec) of prostate cancer after radical prostatectomy (RP). One hundred and twenty patients with prostate cancer who underwent SRT for BRec after RP without evidence of clinical disease were identified in our institution from 2002 to 2014. Prescription doses to prostate beds were 64.8 Gy with a fractional dose of 1.8 Gy in 96.7% of the patients. In three-dimensional conformal radiation therapy (3D-CRT), the seminal vesicle bed (SVB) was not included in the radiation fields...
March 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29559810/moderate-hypofractionated-radiotherapy-after-prostatectomy-for-cancer-patients-toxicity-and-clinical-outcome
#12
Salvina Barra, Liliana Belgioia, Michela Marcenaro, Serena Callegari, Alice Pastorino, Luca Trapani, Francesca Cavagnetto, Stefania Garelli, Renzo Corvò
Background: After radical prostatectomy (RP) radiotherapy (RT) plays a role, both as adjuvant or salvage treatment. If negative features are present such as extracapsular extension, seminal vesicle invasion, lymph invasion, and positive surgical margins, RT after RP reduces the risk of recurrence, although it is associated with an increased risk of acute and late toxicities. An intensified RT delivered in a shortened time could improve clinical outcome and be safely combined with hormonal therapy (HT)...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29556580/salvage-image-guided-radiation-therapy-to-the-prostate-after-cryotherapy-failure
#13
Austin B Hopper, Ajay P S Sandhu, J Kellogg Parsons, Brent Rose, John P Einck
Purpose: Cryotherapy is an option for the primary treatment of localized prostate cancer, along with radical prostatectomy, external beam radiation therapy, and brachytherapy. Although it is known that local recurrence can occur in >20% of patients treated with primary cryotherapy, unfortunately there is a paucity of data on later salvage treatments. The use of external beam radiation therapy is an attractive option after cryotherapy failure, but there is little data on its efficacy and toxicity...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29551263/-salvage-cryotherapy-of-prostate-cancer-after-failed-external-radiotherapy-and-brachytherapy-morbidity-and-mid-term-oncological-results
#14
A Gevorgyan, J-F Hétet, M Robert, V Duchattelle-Dussaule, L Corno, I Boulay, H Baumert
OBJECTIVE: To study the oncologic and functional results of salvage cryotherapy after failure of external radiotherapy and brachytherapy. MATERIALS AND METHODS: Patients treated by total salvage cryotherapy (3rd generation) in 2 centers (Groupe Hospitalier Saint-Joseph in Paris and Clinique Jule-Verne Nantes) in between January 2008 and April 2016 were included. The biochemical recurrence-free survival (BRFS) was calculated using the Phoenix criteria (PSA>nadir+2ng/mL)...
March 15, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29544737/more-extensive-lymph-node-dissection-at-radical-prostatectomy-is-associated-with-improved-outcomes-with-salvage-radiotherapy-for-rising-prostate-specific-antigen-after-surgery-a-long-term-multi-institutional-analysis
#15
Nicola Fossati, William P Parker, R Jeffrey Karnes, Michele Colicchia, Alberto Bossi, Thomas Seisen, Nadia Di Muzio, Cesare Cozzarini, Barbara Noris Chiorda, Claudio Fiorino, Giorgio Gandaglia, Detlef Bartkowiak, Thomas Wiegel, Shahrokh Shariat, Gregor Goldner, Antonino Battaglia, Steven Joniau, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hein Van Poppel, Francesco Montorsi, Alberto Briganti, Stephen A Boorjian
Up to 50% of patients recur after salvage radiation therapy (sRT) for prostate-specific antigen (PSA) rise following radical prostatectomy (RP). Notably, the importance of lymph node dissection (LND) at the time of RP with regard to recurrence risk following sRT has not been previously determined. Therefore, we evaluated the association between nodal yield at RP and recurrence after sRT. We performed a multi-institutional review of men with a rising PSA after RP treated with sRT. Clinicopathologic variables were abstracted, and the associations between lymph node yield and biochemical (BCR) as well as clinical recurrence (CR) after sRT were assessed using multivariable Cox proportional hazards regression models...
March 12, 2018: European Urology
https://www.readbyqxmd.com/read/29543933/effect-of-standard-vs-dose-escalated-radiation-therapy-for-patients-with-intermediate-risk-prostate-cancer-the-nrg-oncology-rtog-0126-randomized-clinical-trial
#16
Jeff M Michalski, Jennifer Moughan, James Purdy, Walter Bosch, Deborah W Bruner, Jean-Paul Bahary, Harold Lau, Marie Duclos, Matthew Parliament, Gerard Morton, Daniel Hamstra, Michael Seider, Michael I Lock, Malti Patel, Hiram Gay, Eric Vigneault, Kathryn Winter, Howard Sandler
Importance: Optimizing radiation therapy techniques for localized prostate cancer can affect patient outcomes. Dose escalation improves biochemical control, but no prior trials were powered to detect overall survival (OS) differences. Objective: To determine whether radiation dose escalation to 79.2 Gy compared with 70.2 Gy would improve OS and other outcomes in prostate cancer. Design, Setting, and Participants: The NRG Oncology/RTOG 0126 randomized clinical trial randomized 1532 patients from 104 North American Radiation Therapy Oncology Group institutions March 2002 through August 2008...
March 15, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29530632/standard-of-care-versus-metastases-directed-therapy-for-pet-detected-nodal-oligorecurrent-prostate-cancer-following-multimodality-treatment-a-multi-institutional-case-control-study
#17
T Steuber, C Jilg, P Tennstedt, A De Bruycker, D Tilki, K Decaestecker, T Zilli, B A Jereczek-Fossa, U Wetterauer, A L Grosu, W Schultze-Seemann, H Heinzer, M Graefen, A Morlacco, R J Karnes, P Ost
BACKGROUND: Most prostate cancer (PCa) patients with a biochemical failure following primary multimodality treatment (surgery and postoperative radiotherapy) relapse in the nodes. OBJECTIVE: To perform a matched-case analysis in men with lymph node recurrent PCa comparing standard of care (SOC) with metastasis-directed therapy (MDT). DESIGN, SETTING, AND PARTICIPANTS: PCa patients with a prostate-specific antigen (PSA) progression following multimodality treatment were included in this retrospective multi-institutional analysis...
March 10, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29526801/bcl2-overexpressing-prostate-cancer-cells-rely-on-parp1-dependent-end-joining-and-are-sensitive-to-combined-parp-inhibitor-and-radiation-therapy
#18
Christoph Oing, Pierre Tennstedt, Ronald Simon, Jennifer Volquardsen, Kerstin Borgmann, Carsten Bokemeyer, Cordula Petersen, Ekkehard Dikomey, Kai Rothkamm, Wael Y Mansour
Here we report that BCL2 blocks DNA double strand break (DSB) repair via nonhomologous end-joining (NHEJ), through sequestration of KU80 protein outside the nucleus. We find that this effect is associated with a repair switch to the error-prone PARP1-dependent end-joining (PARP1-EJ). We present in-vitro proof-of-concept for therapeutic targeting of this switch using PARP inhibitor to specifically enhance the radiosensitivity of BCL2-overexpressing cells. Given its erroneous behavior, PARP1-EJ might allow for the accumulation of genetic alterations and tumor progression...
March 8, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29523103/androgen-deprivation-therapy-during-and-after-post-prostatectomy-radiotherapy-in-patients-with-prostate-cancer-a-case-control-study
#19
Myong Kim, Cheryn Song, In Gab Jeong, Seung-Kwon Choi, Myungchan Park, Myungsun Shim, Young Seok Kim, Dalsan You, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn
BACKGROUND: Here we assessed the influence of androgen deprivation therapy (ADT) during and/or after post-prostatectomy radiotherapy (RT) on biochemical recurrence (BCR) and radiographic progression in patients with prostate cancer. METHODS: Patients with prostate cancer who underwent post-prostatectomy RT were analyzed. BCR and radiographic progression after RT were compared according to the concurrent or salvage ADT. Cox regression analyses were used to identify risk factors for BCR and radiographic progression...
March 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29520383/can-pelvic-node-dissection-at-radical-prostatectomy-influence-the-nodal-recurrence-at-salvage-lymphadenectomy-for-prostate-cancer
#20
Arjun Sivaraman, Nicole Benfante, Karim Touijer, Jonathan Coleman, Peter Scardino, Vincent Laudone, James Eastham
Purpose: To verify the quality of pelvic lymph node dissection (PLND) performed at radical prostatectomy (RP) and its impact on nodal recurrence in patients undergoing salvage lymph node dissection (sLND). Materials and Methods: Retrospective review of 48 patients who underwent sLND for presumed nodal recurrence, to describe the PLND characteristics at RP and correlate the anatomical sites and number of suspicious nodes reported in radiological imaging and final pathology of sLND...
March 2018: Investigative and Clinical Urology
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