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https://www.readbyqxmd.com/read/29052761/does-surgical-delay-for-radical-prostatectomy-affect-biochemical-recurrence-a-retrospective-analysis-from-a-canadian-cohort
#1
Marc Zanaty, Mansour Alnazari, Khaled Ajib, Kelsey Lawson, Mounsif Azizi, Emad Rajih, Abdullah Alenizi, Pierre-Alain Hueber, Côme Tolmier, Malek Meskawi, Fred Saad, Raisa S Pompe, Pierre I Karakiewicz, Assaad El-Hakim, Kevin C Zorn
AIM: We sought to explore the impact of surgical wait time (SWT) to robot-assisted radical prostatectomy (RARP) on biochemical recurrence (BCR). METHOD: Retrospective review of a prospectively collected database between 2006 and 2015 was conducted on all RARP cases. SWT was defined as period from prostate biopsy to surgery. Primary outcome was the impact on BCR, which was defined as two consecutive PSA ≥ 0.2 ng/dl, or salvage external beam radiation therapy and/or salvage androgen deprivation therapy...
October 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29049492/association-of-hsd3b1-genotype-with-response-to-androgen-deprivation-therapy-for-biochemical-recurrence-after-radiotherapy-for-localized-prostate-cancer
#2
Jason W D Hearn, Wanling Xie, Mari Nakabayashi, Nima Almassi, Chad A Reichard, Mark Pomerantz, Philip W Kantoff, Nima Sharifi
Importance: The variant HSD3B1 (1245C) allele enhances dihydrotestosterone synthesis and predicts resistance to androgen-deprivation therapy (ADT) for biochemically recurrent prostate cancer after prostatectomy and for metastatic disease. Whether this is true after radiotherapy is unknown. Objective: To determine whether the HSD3B1 (1245C) allele predicts worse clinical outcomes from ADT for biochemical recurrence after radiotherapy. Design, Setting, and Participants: The Prostate Clinical Research Information System at Dana-Farber Cancer Institute was used to identify the study cohort, which included men treated with ADT for biochemical recurrence after primary radiotherapy between 1996 and 2013...
October 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29033101/re-salvage-high-intensity-focused-ultrasound-hifu-for-locally-recurrent-prostate-cancer-after-failed-radiation-therapy-multi-institutional-analysis-of-418-patients
#3
https://www.readbyqxmd.com/read/29029496/-177-lu-psma-617-radioligand-therapy-for-a-patient-with-lymph-node-metastatic-prostate-cancer
#4
Finn E von Eyben, Timo Kiljunen, Timo Joensuu, Kalevi Kairemo, Christian Uprimny, Irene Virgolini
Prostate specific membrane antigen (PSMA) is expressed in unfavorable prostate cancer. PSMA is basis for new diagnostics and theranostics. PET/CT using PSMA is more sensitive than choline PET/CT. (177)Lu-PSMA radioligand therapy is mainly used for patients with end-stage prostate cancer. This report describes a patient with a third recurrence in lymph nodes. The recurrence was treated with (177)Lu-PSMA radioligand therapy instead of chemotherapy with docetaxel. The effect was in part evaluated relative to that of two established salvage treatments...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028767/prostate-specific-membrane-antigen-guided-salvage-lymph-node-dissection-in-recurrent-prostate-cancer-a-novel-technology-to-detect-lymph-node-metastases
#5
Tobias Maurer, Jürgen E Gschwend, Matthias Eiber
PURPOSE OF REVIEW: With Gallium (Ga)-prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) as emerging imaging technique offering superior detection rates in biochemical recurrent prostate cancer, salvage lymph node dissection has gained increasing interest in localized oligometastatic prostate cancer. Currently, PSMA-targeting small molecules cannot only be linked to positron-emitting isotopes for imaging but also be labelled with γ-radiation emitting isotopes. These modified PSMA agents are evaluated for intraoperative guidance for resection of metastatic lymph nodes...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29020683/combination-of-androgen-deprivation-therapy-and-salvage-radiotherapy-versus-salvage-radiotherapy-alone-for-recurrent-prostate-cancer-after-radical-prostatectomy
#6
Sangjun Yoo, Dalsan You, Young Seok Kim, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
INTRODUCTION: To assess the value of androgen deprivation therapy (ADT) on salvage radiotherapy (RT) in post-prostatectomy recurrent prostate cancer patients, we compared the oncologic outcomes between patients receiving RT + ADT and those receiving RT alone. MATERIALS AND METHODS: We reviewed the records of patients diagnosed with prostate cancer between 1995 and 2011, including 93 patients who underwent salvage RT and 69 patients who underwent salvage RT + ADT...
October 12, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28984165/target-definition-in-salvage-postoperative-radiotherapy-for-prostate-cancer-18f-fluorocholine-pet-ct-assessment-of-local-recurrence
#7
Osman El Kabbaj, Philippe Robin, David Bourhis, Gurvan Dissaux, Nicola Rosenfelder, Antoine Valeri, Georges Fournier, Pierre-Yves Salaun, Olivier Pradier, Jean-Pierre Malhaire, Ronan Abgral, Ulrike Schick
PURPOSE: Inadequate clinical target volume (CTV) definition is likely to be a major contributing factor to local recurrence (LR) rate after radiotherapy. Our aims were to identify sites of prostate cancer LR in biochemical recurrence post-prostatectomy using (18)F-Fluorocholine (18F-FCH) positron emission tomography/computed tomography (PET/CT) and to compare different CTV-delineation guidelines in a cohort of postoperative patients. MATERIAL AND METHODS: Thirty-six patients presenting with LR within the prostatic bed on 18F-FCH PET/CT between 10/2011 and 06/2016 were included in this retrospective study...
October 6, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28983643/-radical-prostatectomy-in-locally-advanced-prostate-cancer
#8
REVIEW
P Mandel, D Tilki, M Graefen
BACKGROUND: Due to an inverse stage migration, the proportion of patients with more aggressive and locally advanced prostate cancer (PCa) has increased over the last few years. The natural history in these patients shows a higher risk of local complications and worse oncologic outcome. OBJECTIVES: To analyze the impact of radical prostatectomy (RP) in patients with locally advanced PCa. MATERIALS AND METHODS: A review of the literature was performed using PubMed and MEDLINE databases focusing on articles addressing locally advanced PCa...
October 5, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28982880/differential-risk-of-castration-resistance-after-initial-radical-prostatectomy-or-radiotherapy-for-prostate-cancer
#9
COMPARATIVE STUDY
Hirofumi Obata, Masaki Shiota, Naoko Akitake, Ario Takeuchi, Eiji Kashiwagi, Takashi Dejima, Keijiro Kiyoshima, Junichi Inokuchi, Katsunori Tatsugami, Masatoshi Eto
BACKGROUND/AIM: Salvage androgen-deprivation therapy (ADT) is standard treatment for recurrent prostate cancer after curative therapy. However, the prognostic impact of different treatment modalities on the time to castration resistance remains unclear. In this study, we investigated the prognosis of men treated with salvage ADT after initial radical prostatectomy or radiotherapy for prostate cancer. PATIENTS AND METHODS: Between 2000 and 2013, 149 Japanese men with recurrent prostate cancer who were initially treated with radical prostatectomy (n=95) or radiotherapy (n=54) and were subsequently treated with salvage ADT after disease recurrence were enrolled in this study...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28980045/-the-role-of-psma-pet-ct-in-patients-with-metastatic-prostate-cancer
#10
REVIEW
J von Hardenberg, K-A Büsing, P Nuhn, M Ritter
Prostate-specific membrane antigen (PSMA) positron emission tomography-computed tomography (PET-CT) imaging for the localization of prostate cancer is increasingly available in Germany. The advances and limitations in different disease stages are reviewed. As the clinical relevance of oligometastatic disease in primary cancer detected by PSMA PET-CT imaging is not yet completely understood, it should only be used in clinical trials. In recurrent prostate cancer after therapy with curative intent, PSMA PET-CT shows encouraging potential for the planning of salvage therapy...
October 4, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28959145/the-use-of-intraoperative-cell-salvage-in-urologic-oncology
#11
Matthew C Ferroni, Andres F Correa, Timothy D Lyon, Benjamin J Davies, Michael C Ost
Intraoperative cell salvage (IOCS) has been used in urologic surgery for over 20 years to manage intraoperative blood loss and effectively minimize the need for allogenic blood transfusion. Concerns about viability of transfused erythrocytes and potential dissemination of malignant cells have been addressed in the urologic literature. We present a comprehensive review of the use of IOCS in urologic oncologic surgery. IOCS has been shown to preserve the integrity of erythrocytes during processing and effectively provides cell filtration to mitigate the risk of tumor dissemination...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28958827/re-robot-assisted-salvage-lymph-node-dissection-for-clinically-recurrent-prostate-cancer
#12
Vito Pansadoro, Aldo Brassetti
No abstract text is available yet for this article.
September 25, 2017: European Urology
https://www.readbyqxmd.com/read/28951757/oncological-outcome-complications-lower-urinary-tract-symptoms-and-health-related-quality-of-life-after-low-dose-rate-salvage-brachytherapy-for-recurrent-prostate-cancer-following-primary-radiotherapy-a-report-of-8-cases
#13
Makito Miyake, Nobumichi Tanaka, Isao Asakawa, Shunta Hori, Yosuke Morizawa, Yasushi Nakai, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nagaaki Marugami, Masatoshi Hasegawa, Tomomi Fujii, Noboru Konishi, Kiyohide Fujimoto
PURPOSE: We evaluated our experience with low-dose-rate salvage brachytherapy for local recurrence after primary prostate radiotherapy, and described the changes in lower urinary tract symptoms and health-related quality of life. MATERIAL AND METHODS: Between 2011 and 2016, eight men with local recurrence after primary prostate radiotherapy underwent iodine-125 salvage brachytherapy with a prescribed dose of 110 or 145 Gy. Recurrence-free survival was evaluated with a post-treatment prostate-specific antigen profile...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28948333/phase-i-ii-trial-of-dendritic-cell-based-active-cellular-immunotherapy-with-dcvac-pca-in-patients-with-rising-psa-after-primary-prostatectomy-or-salvage-radiotherapy-for-the-treatment-of-prostate-cancer
#14
Jitka Fucikova, Michal Podrazil, Ladislav Jarolim, Pavla Bilkova, Michal Hensler, Etienne Becht, Zdenka Gasova, Jana Klouckova, Jana Kayserova, Rudolf Horvath, Anna Fialova, Katerina Vavrova, Klara Sochorova, Daniela Rozkova, Radek Spisek, Jirina Bartunkova
OBJECTIVE: Immunotherapy of cancer has the potential to be effective mostly in patients with a low tumour burden. Rising PSA (prostate-specific antigen) levels in patients with prostate cancer represents such a situation. We performed the present clinical study with dendritic cell (DC)-based immunotherapy in this patient population. MATERIALS AND METHODS: The single-arm phase I/II trial registered as EudraCT 2009-017259-91 involved 27 patients with rising PSA levels...
September 25, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28931292/-salvage-lymph-node-dissection-in-radical-prostatectomy-failure-a-case-study
#15
N Marečková, M Staník, D Macík, J Doležel
Salvage lymph node dissection is a therapeutic option in patients with nodal-only recurrence after radical prostatectomy. Although this operation does not achieve a complete cure in the majority of cases, it can prolong survival and help postpone hormonal therapy in selected patients while being a relatively safe procedure. The authors describe a case study of a radical prostatectomy patient with radiologically proven recurrence of prostate cancer limited to an internal iliac node. He underwent salvage lymph node dissection with a complete biochemical response...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28927782/development-and-internal-validation-of-prediction-models-for-biochemical-failure-and-composite-failure-after-focal-salvage-high-intensity-focused-ultrasound-for-local-radiorecurrent-prostate-cancer-presentation-of-risk-scores-for-individual-patient-prognoses
#16
Max Peters, Abi Kanthabalan, Taimur T Shah, Neil McCartan, Caroline M Moore, Manit Arya, Jochem R van der Voort van Zyp, Marinus A Moerland, Richard G Hindley, Mark Emberton, Hashim U Ahmed
PURPOSE: Patient selection for focal salvage remains difficult. Therefore, we developed and internally validated prediction models for biochemical failure (BF) and a composite endpoint (CE) following focal salvage high intensity focused ultrasound (HIFU) for radiorecurrent prostate cancer. MATERIALS AND METHODS: A prospective HIFU registry identified 150 cases (November 2006-August 2015). Recurrence was assessed with multiparametric magnetic resonance imaging (MRI) combined with template prostate mapping biopsies, targeted biopsies, or systematic transrectal ultrasound-guided biopsies...
September 15, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28924967/postoperative-radiotherapy-for-prostate-cancer-the-sooner-the-better-and-potential-to-reduce-toxicity-even-further
#17
Paolo Borghetti, Luigi Spiazzi, Claudia Cozzaglio, Sara Pedretti, Bruno Caraffini, Luca Triggiani, Diana Greco, Lilia Bardoscia, Fernando Barbera, Michela Buglione, Stefano Maria Magrini
PURPOSE: To evaluate biochemical relapse-free survival (bRFS), overall survival (OS), late rectal and bladder toxicities in a retrospective single institution series, also applying an in-house software for biological dose calculation. METHODS: 258 patients submitted to radiotherapy after prostatectomy were considered. Differences between groups were calculated using the log-rank test and the relevant clinical and therapeutic variables were considered for multivariate analysis...
September 18, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28922958/post-prostatectomy-radiation-therapy-for-locally-recurrent-prostate-cancer
#18
Sudhir Isharwal, Andrew J Stephenson
Approximately 15-30% of men with localized prostate cancer will experience biochemical recurrence (BCR) after radical prostatectomy. Postoperative radiation therapy is used in men with adverse pathological features to reduce the risk of BCR or with curative intent in men with known BCR. In this study, we review the evidence for the adjuvant and salvage radiation therapy after radical prostatectomy. Areas covered: A literature review of the Medline and Embase databases was performed. The search strategy included the following terms: prostate cancer, adjuvant radiotherapy, salvage radiotherapy, radical prostatectomy, biochemical recurrence, and prostate cancer recurrence...
November 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28919352/salvage-brachytherapy-for-radiorecurrent-prostate-cancer-searching-for-safety-and-success
#19
EDITORIAL
Max Peters, Marinus A Moerland, Jochem R N van der Voort van Zyp
No abstract text is available yet for this article.
September 14, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28916253/the-place-of-transanal-endoscopic-surgery-in-the-treatment-of-recto-urethral-fistula
#20
X Serra-Aracil, M Labro-Ciurans, L Mora-Lopez, J Muñoz-Rodriguez, R Martos-Calvo, J Prats-López, S Navarro-Soto
OBJECTIVES: To assess the role of TEO/TEM in recto-urethral fistulas (RUF). RUF may appear after radical prostatectomy. Their treatment represents a challenge; many therapies have been proposed, from conservative to aggressive surgical approaches. Transanal endoscopic surgery (TEO/TEM) is a minimally invasive technique to access the site of the RUF to perform repair. METHODS: Observational study with prospective data collection, conducted between September 2006 and December 2015...
September 12, 2017: Urology
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