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https://www.readbyqxmd.com/read/29230008/positive-margin-length-and-highest-gleason-grade-of-tumor-at-the-margin-predict-for-biochemical-recurrence-after-radical-prostatectomy-in-patients-with-organ-confined-prostate-cancer
#1
Brian F Chapin, Jenny N Nguyen, Mary F Achim, Neema Navai, Stephen B Williams, Ina N Prokhorova, Xuemei Wang, Elsa M Li Ning Tapia, John W Davis, Patricia Troncoso
BACKGROUND: To evaluate the pathologic features after radical prostatectomy to determine if the length of positive surgical margin (PSM) and the highest Gleason grade within the tumor at the PSM could risk stratify patients for biochemical recurrence (BCR). METHODS: We performed a retrospective, matched, cohort study to identify patients with pathologically organ-confined (pT2) tumors and negative nodes (pN0/Nx), receiving no adjuvant therapy. Specimens underwent single pathologist review...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29229176/use-of-concomitant-androgen-deprivation-therapy-in-patients-treated-with-early-salvage-radiotherapy-for-biochemical-recurrence-after-radical-prostatectomy-long-term-results-from-a-large-multi-institutional-series
#2
Giorgio Gandaglia, Nicola Fossati, R Jeffrey Karnes, Stephen A Boorjian, Michele Colicchia, Alberto Bossi, Thomas Seisen, Cesare Cozzarini, Nadia Di Muzio, Barbara Noris Chiorda, Emanuele Zaffuto, Thomas Wiegel, Shahrokh F Shariat, Gregor Goldner, Steven Joniau, Antonino Battaglia, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hendrick Van Poppel, Francesco Montorsi, Alberto Briganti
BACKGROUND: Hormonal manipulation concomitant to salvage radiotherapy (SRT) given for biochemical recurrence (BCR) after radical prostatectomy (RP) improved outcomes in two randomized trials. However, neither of these studies focused on men treated at low prostate-specific antigen (PSA) levels. OBJECTIVE: To test if the impact of androgen deprivation therapy (ADT) on metastasis in patients undergoing early SRT varies according to prostate cancer (PCa) features. DESIGN, SETTING, AND PARTICIPANTS: A total of 525 patients received SRT at PSA levels ≤2ng/ml...
December 8, 2017: European Urology
https://www.readbyqxmd.com/read/29223469/oncological-and-functional-outcomes-of-elderly-men-treated-with-hifu-vs-minimally-invasive-radical-prostatectomy-a-propensity-score-analysis
#3
Paolo Capogrosso, Eric Barret, Rafael Sanchez-Salas, Igor Nunes-Silva, François Rozet, Marc Galiano, Eugenio Ventimiglia, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Xavier Cathelineau
AIM: To assess outcomes of whole gland high-intensity focused ultrasound (HIFU) as compared with minimally-invasive radical prostatectomy (MIRP) in elderly patients. MATERIALS & METHODS: Patients aged ≥70 years with, cT1-cT2 disease, biopsy Gleason score (GS) 3 + 3 or 3 + 4 and preoperative PSA ≤10 ng/mL were submitted to either whole-gland HIFU or MIRP. Propensity-score matching analysis was performed to ensure the baseline equivalence of groups. Follow-up visits were routinely performed assessing PSA and urinary function according to the International Continence Score (ICS) and the International Prostatic Symptoms Score (IPSS) questionnaires...
December 1, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29211405/high-intensity-focused-ultrasound-hifu-as-salvage-therapy-for-radio-recurrent-prostate-cancer-predictors-of-disease-response
#4
Shawn Dason, Nathan C Wong, Christopher B Allard, Jen Hoogenes, William Orovan, Bobby Shayegan
BACKGROUND: Some men with localized radio-recurrent prostate cancer may benefit from salvage high-intensity focused ultrasound (HIFU). Herein, we describe oncologic outcomes and predictors of disease response after salvage whole gland HIFU from our prospective cohort. MATERIALS AND METHODS: Patients with localized radio-recurrent prostate cancer were prospectively enrolled from January 2005 to December 2014. Participants had to meet both biochemical and histological definitions of recurrence...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29207866/interobserver-variation-in-target-volume-for-salvage-radiotherapy-in-recurrent-prostate-cancer-patients-after-radical-prostatectomy-using-ct-versus-combined-ct-and-mri-a-multicenter-study-krog-13-11
#5
Eonju Lee, Won Park, Sung Hwan Ahn, Jae Ho Cho, Jin Hee Kim, Kwan Ho Cho, Young Min Choi, Jae-Sung Kim, Jin Ho Kim, Hong-Seok Jang, Young-Seok Kim, Taek-Keun Nam
Purpose: To investigate interobserver variation in target volume delineations for prostate cancer salvage radiotherapy using planning computed tomography (CT) versus combined planning CT and magnetic resonance imaging (MRI). Materials and Methods: Ten radiation oncologists independently delineated a target volume on the planning CT scans of five cases with different pathological status after radical prostatectomy. Two weeks later, this was repeated with the addition of planning MRI...
December 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29204527/outcomes-and-toxicity-of-313-prostate-cancer-patients-receiving-helical-tomotherapy-after-radical-prostatectomy
#6
Lindsay Jensen, Bertram Yuh, Jeffrey Y C Wong, Timothy Schultheiss, Jonathan Cheng, Nora Ruel, Przemyslaw Twardowski, Sagus Sampath
Purpose: There are limited long-term data on patients treated with image guided intensity modulated radiation therapy (IG-IMRT) for prostate cancer recurrence or high-risk disease features after radical prostatectomy. We report single-institution results for patients treated with IG-IMRT and identify variables associated with outcome. Methods and materials: This is a retrospective chart review consisting of 313 consecutive patients who were treated with adjuvant or salvage IG-IMRT from 2004 to 2013...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29195777/multiparametric-magnetic-resonance-imaging-is-an-independent-predictor-of-salvage-radiotherapy-outcomes-after-radical-prostatectomy
#7
REVIEW
Vidit Sharma, Avinash Nehra, Michele Colicchia, Mary E Westerman, Akira Kawashima, Adam T Froemming, Eugene D Kwon, Lance A Mynderse, R Jeffrey Karnes
BACKGROUND: The Stephenson nomogram is widely used to estimate the success of salvage radiotherapy (sXRT) for prostate cancer (PCa) recurrence after radical prostatectomy (RP). OBJECTIVE: To determine whether multiparametric pelvic magnetic resonance imaging (mpMRI) performed for biochemical recurrence after RP improves prognostication of sXRT relative to the Stephenson nomogram. DESIGN, SETTING, AND PARTICIPANTS: Men undergoing RP at our institution from 2003 to 2012 who had biochemical recurrence evaluated by mpMRI within 12 mo of sXRT were retrospectively reviewed...
November 28, 2017: European Urology
https://www.readbyqxmd.com/read/29188197/68ga-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-in-advanced-prostate-cancer-current-state-and-future-trends
#8
REVIEW
Cristian Udovicich, Marlon Perera, Michael S Hofman, Shankar Siva, Andres Del Rio, Declan G Murphy, Nathan Lawrentschuk
The early and accurate detection of prostate cancer is important to ensure timely management and appropriate individualized treatment. Currently, conventional imaging has limitations particularly in the early detection of metastases and at prostate-specific antigen (PSA) levels < 2.0 ng/mL. Furthermore, disease management such as salvage radiotherapy is best at low PSA levels. Thus, it is critical to capture the disease in the oligometastatic stage as disease progression and commencement of systemic therapies can be delayed by metastasis-directed therapy...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29186937/how-to-use-pet-ct-in-the-evaluation-of-response-to-radiotherapy
#9
Pierre Decazes, Sébastien Thureau, Bernard Dubray, Pierre Vera
INTRODUCTION: Radiotherapy is a major treatment modality for many cancers. Tumor response after radiotherapy determines the subsequent steps of the patient's management (surveillance, adjuvant or salvage treatment and palliative care). Tumor response assessed during radiotherapy offers a promising opportunity to adapt the treatment plan to reduced / increased target volume, to specifically target sub-volumes with relevant biological characteristics (metabolism, hypoxia, proliferation ...
November 28, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29178983/hypofractionated-radiotherapy-for-prostate-cancer-in-the-postoperative-setting-what-is-the-evidence-so-far
#10
REVIEW
Cristina Picardi, Ioan Perret, Raymond Miralbell, Thomas Zilli
Postoperative external beam radiation therapy (EBRT) is a validated treatment option in the adjuvant setting for prostate cancer patients with aggressive pathological features following radical prostatectomy (RP) or as salvage modality in patients with biochemical recurrence after RP. Contemporary randomized phase III trials have provided evidence for using hypofractionation in the definitive treatment setting as an alternative to standard fractionated regimens. Biomathematical modeling for prostate cancer fractionated EBRT associated with widely available refined treatment delivery techniques such as volumetric modulated-arc therapy with image-guided RT may improve the therapeutic ratio...
November 14, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29169704/cumulative-incidence-and-predictive-factors-of-radiation-cystitis-in-patients-with-localized-prostate-cancer
#11
D Afonso-João, L Pacheco-Figueiredo, T Antunes-Lopes, L A Morgado, V Azevedo, L Vendeira, J Silva, C Martins-Silva
PURPOSE: To determine the cumulative incidence of overall and severe radiation cystitis in a high volume cohort of patients and to investigate its potential predictive factors. METHODS: We have performed a retrospective analysis of clinical data from patients diagnosed with localized prostate cancer and treated with radiotherapy at our institution (June 2005-January 2013), and quantified the cumulative incidence of radiation cystitis. Cox regression analysis and Kaplan-Meier curves were computed to evaluate the determinants of radiation cystitis...
November 20, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29169666/erratum-to-postoperative-adjuvant-and-salvage-radiotherapy-for-prostate-cancer-impact-on-freedom-from-biochemical-relapse-and-survival
#12
(no author information available yet)
No abstract text is available yet for this article.
November 20, 2017: Urology
https://www.readbyqxmd.com/read/29162647/a-unifying-biology-of-sex-steroid-induced-apoptosis-in-prostate-and-breast-cancers
#13
Philipp Y Maximov, Balkees Abderrahman, Ramona F Curpan, Yousef A Hawsawi, Ping Fan, V Craig Jordan
Prostate and breast cancer are the two cancers with the highest incidence in men and women, respectively. Here we focus on the known biology of acquired resistance to antihormone therapy of prostate and breast cancer and compare laboratory and clinical similarities in the evolution of the disease. Laboratory studies and clinical observations in prostate and breast cancer demonstrate that cell selection pathways occur during acquired resistance to antihormonal therapy. Following sex steroid deprivation, both prostate and breast cancer models show an initial increased acquired sensitivity to the growth potential of sex steroids...
November 21, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29161715/management-of-biochemical-recurrence-after-primary-curative-treatment-for-prostate-cancer-a-review
#14
Walter Artibani, Antonio Benito Porcaro, Vincenzo De Marco, Maria A Cerruto, Salvatore Siracusano
How to manage patients with prostate cancer (PCa) with biochemical recurrence (BCR) following primary curative treatment is a controversial issue. Importantly, this prostate-specific antigen (PSA)-only recurrence is a surrogate neither of PCa-specific survival nor of overall survival. Physicians are therefore challenged with preventing or delaying the onset of clinical progression in those deemed at risk, while avoiding over-treating patients whose disease may never progress beyond PSA-only recurrence. Adjuvant therapy for radical prostatectomy (RP) or local radiotherapy (RT) has a role in certain at-risk patients, although it is not recommended in low-risk PCa owing to the significant side-effects associated with RT and androgen deprivation therapy (ADT)...
November 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29151782/salvage-low-dose-rate-brachytherapy-for-recurrent-prostate-cancer-after-external-beam-radiotherapy-results-from-a-single-institution-with-focus-on-toxicity-and-functional-outcomes
#15
F Barbera, L Triggiani, M Buglione, P Ghirardelli, P Vitali, B Caraffini, P Borghetti, D Greco, L Bardoscia, N Pasinetti, L Costa, M Maddalo, B Ghedi, B La Face, S M Magrini
Background/aim: Low dose rate brachytherapy has been used as salvage therapy for locally recurrent prostate cancer (PC) after primary external beam radiation therapy (EBRT), along with surgery and cryotherapy. All these techniques, in particular, when applied to the whole gland, involve a relatively high risk of toxicity and may worsen the patient's quality of life. Our aim is to evaluate the results of whole-gland salvage brachytherapy (SBT) after primary EBRT in terms of toxicity, functional outcomes, and efficacy...
2017: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/29139652/liposarcoma-of-the-spermatic-cord-%C3%A2-a-rare-pathological-entity
#16
Nikola Radović, Arianna Bizatzki, Rajka Turner
Liposarcoma of the spermatic cord is a very rare neoplasm with fewer than 200 cases recorded in world literature. This report describes a case of liposarcoma of the spermatic cord which developed after radical prostatectomy and salvage radiotherapy for prostate cancer treatment. Four years following surgical treatment of the primary neoplasm and one year following radiotherapy, the 67 –year –old patient was referred to the urology clinic for the emergence of a mass in the right hemiscrotum region. Ultrasonography revealed a homogenous isodense mass measuring 4...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29137414/salvage-lymph-node-dissection-after-68-ga-psma-or-18-f-fec-pet-ct-for-nodal-recurrence-in-prostate-cancer-patients
#17
Annika Herlemann, Alexander Kretschmer, Alexander Buchner, Alexander Karl, Stefan Tritschler, Lina El-Malazi, Wolfgang P Fendler, Vera Wenter, Harun Ilhan, Peter Bartenstein, Christian G Stief, Christian Gratzke
The management of patients with biochemical recurrence (BCR) after definitive treatment for prostate cancer remains controversial. Our aim was to determine survival rates and complications of salvage lymph node dissection (sLND) in patients with recurrent prostate cancer after radical prostatectomy, while evaluating biochemical response (BR) with two different positron emission tomography/computed tomography (PET/CT) tracers used for preoperative imaging. sLND was performed in 104 patients diagnosed with isolated nodal recurrence on either (18)F-fluoroethylcholine ((18)F-FEC) or (68)Ga-PSMA-HBED-CC ((68)Ga-PSMA) PET/CT...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134280/delayed-response-after-repeated-177-lu-psma-617-radioligand-therapy-in-patients-with-metastatic-castration-resistant-prostate-cancer
#18
Kambiz Rahbar, Martin Bögeman, Anna Yordanova, Maria Eveslage, Michael Schäfers, Markus Essler, Hojjat Ahmadzadehfar
PURPOSE: Radioligand therapy (RLT) using Lutetium-177 labeled PSMA-617 (Lu-PSMA) ligand is a new therapeutic option for salvage therapy in heavily pretreated patients with metastatic castration resistant prostate cancer. The aim of this retrospective study was to analyze response in patients receiving 3 cycles of Lu-PSMA. METHODS: Seventy-one patients (median age: 72 years; range 44-87) received 3 cycles of RLT with Lu-PSMA (mean administered activity: 6.016 ± 0...
November 13, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29134231/patterns-of-relapse-as-determined-by-68-ga-psma-ligand-pet-ct-after-radical-prostatectomy-importance-for-tailoring-and-individualizing-treatment
#19
Christoph Henkenberens, Thorsten Derlin, Frank M Bengel, Tobias L Ross, Hans-Jürgen Wester, Katja Hueper, Markus A Kuczyk, Hans Christiansen, Christoph A von Klot
PURPOSE: To evaluate the patterns of relapse and impact on the intended treatment when using (68)Ga-prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) imaging for restaging of disease in patients with biochemical relapse after radical prostatectomy (RP) before salvage radiotherapy (sRT). METHODS: In all, 39 patients with biochemical recurrence after RP who had no primary indication for adjuvant RT due to the absence of biologically unfavorable disease (e...
November 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29133278/imaging-for-the-detection-of-locoregional-recurrences-in-biochemical-progression-after-radical-prostatectomy-a-systematic-review
#20
REVIEW
Kristina Sandgren, Philippe Westerlinck, Joakim H Jonsson, Lennart Blomqvist, Camilla Thellenberg Karlsson, Tufve Nyholm, Piet Dirix
CONTEXT: Local and regional recurrence after radical prostatectomy (RP) can be treated using salvage radiotherapy (SRT). If the recurrence can be delineated on diagnostic imaging, this could allow for increasingly individualized SRT. OBJECTIVE: This systematic review aimed at evaluating the evidence regarding the usefulness of positron emission tomography (PET) and magnetic resonance imaging (MRI) in identifying local and regional recurrences, with the aim to further individualize the SRT treatment...
November 10, 2017: European Urology Focus
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