Jerry Tsai, Sadakatali Gori, Jesse Alt, Sandhya Tiwari, Jitesh Iyer, Rashmi Talwar, Denish Hinsu, Kailash Ahirwar, Swayam Mohanty, Chintan Khunt, Brijesh Sutariya, Kaushal Jani, Venkatesha Venkatasubbaiah, Ashok Patel, Jasmin Meghapara, Kaushal Joshi, Rajanikanta Sahu, Vijay Rana, Prashant Nigade, Ravi S Talluri, Kadiyala V S N Murty, Kiritkumar Joshi, Vikram Ramanathan, Ang Li, Nasif Islam, Ivan Snajdr, Pavel Majer, Rana Rais, Barbara S Slusher, Luis A Garza
Alopecia areata is a chronic hair loss disorder that involves autoimmune disruption of hair follicles by CD8+ T cells. Most patients present with patchy hair loss on the scalp that improves spontaneously or with topical and intralesional steroids, topical minoxidil, or topical immunotherapy. However, recurrence of hair loss is common, and patients with extensive disease may require treatment with oral corticosteroids or oral Janus kinase (JAK) inhibitors, both of which may cause systemic toxicities with long-term use...
January 2023: PNAS Nexus