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cutaneous leishmaniasis

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https://www.readbyqxmd.com/read/28076470/first-description-of-leishmania-viannia-infection-in-evandromyia-saulensis-pressatia-sp-and-trichophoromyia-auraensis-psychodidae-phlebotominae-in-a-transmission-area-of-cutaneous-leishmaniasis-in-acre-state-amazon-basin-brazil
#1
Thais de Araujo-Pereira, Daniela de Pita-Pereira, Mariana Côrtes Boité, Myllena Melo, Taiana Amancio da Costa-Rego, Andressa Alencastre Fuzari, Reginaldo Peçanha Brazil, Constança Britto
Studies on the sandfly fauna to evaluate natural infection indexes are still limited in the Brazilian Amazon, a region with an increasing incidence of cutaneous leishmaniasis. Here, by using a multiplex polymerase chain reaction directed to Leishmania kDNA and hybridisation, we were able to identify L. (Viannia) subgenus in 12 out of 173 sandflies captured in the municipality of Rio Branco, Acre state, revealing a positivity of 6.94%. By sequencing the Leishmania 234 bp-hsp70 amplified products from positive samples, infection by L...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28076468/phenotypic-diversity-and-selection-maintain-leishmania-amazonensis-infectivity-in-balb-c-mouse-model
#2
Benoît Espiau, Virginia Vilhena, Armelle Cuvillier, Aldina Barral, Gilles Merlin
Leishmania are protozoan parasites that show remarkable diversity, as revealed by the various clinical forms of leishmaniasis, which can range from mild skin lesions to severe metastatic cutaneous/mucosal lesions. The exact nature and extent of Leishmania phenotypic diversity in establishing infection is not fully understood. In order to try to understand some aspects of this diversity, we subcutaneously infected BALB/c mice with first and second generation subclones of a L. amazonensis strain isolated from a patient (BA125) and examined in vivo lesion growth rate and antimony susceptibility...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28076241/phenotypic-and-functional-characteristics-of-hla-dr-neutrophils-in-brazilians-with-cutaneous-leishmaniasis
#3
Richard E Davis, Smriti Sharma, Jacilara Conceição, Pedro Carneiro, Fernanda Novais, Phillip Scott, Shyam Sundar, Olivia Bacellar, Edgar M Carvalho, Mary E Wilson
The protozoan Leishmania braziliensis causes cutaneous leishmaniasis (CL) in endemic regions. In murine models, neutrophils (PMNs) are recruited to the site of infection soon after parasite inoculation. However, the roles of neutrophils during chronic infection and in human disease remain undefined. We hypothesized that neutrophils help maintain a systemic inflammatory state in subjects with CL. Lesion biopsies from all patients with CL tested contained neutrophils expressing HLA-DR, a molecule thought to be restricted to professional antigen-presenting cells...
October 17, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28071592/development-and-evaluation-of-zinc-phthalocyanine-nanoemulsions-for-use-in-photodynamic-therapy-for-leishmania-spp
#4
Luciana Betzler de Oliveira de Siqueira, Verônica da Silva Cardoso, Igor Almeida Rodrigues, Ana Lúcia Vazquez-Villa, Elisabete Pereira Dos Santos, Bruno da Costa Leal Ribeiro Guimarães, Cristal Dos Santos Cerqueira Coutinho, Alane Beatriz Vermelho, Eduardo Ricci Junior
Photodynamic therapy (PDT) combines light with photosensitizers (PS) for production of reactive oxygen species (ROS) that can kill infectious microorganisms such as bacteria, fungi and protozoa. The application of nanotechnology has enabled the advancement of PDT because many PS are insoluble in water, necessitating a nanocarrier as a physiologically acceptable carrier. Nanoemulsions are efficient nanocarriers for solubilizing liposoluble drugs, like the PS, in water. Cutaneous (CL) and mucocutaneous leishmaniasis (ML) are caused by different species of the genus Leishmania, transmitted to humans by sandfly bites...
February 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28061874/slc11a1-polymorphisms-and-host-susceptibility-to-cutaneous-leishmaniasis-in-pakistan
#5
Mariam Sophie, Abdul Hameed, Akhtar Muneer, Azam J Samdani, Saima Saleem, Abid Azhar
BACKGROUND: The vector-borne cutaneous leishmaniasis (CL) is endemic in several regions of Pakistan mainly affecting poor populations. Host genetic factors, particularly SLC11A1 (solute carrier transmembrane protein) within macrophages, play a crucial role in disease pathology and susceptibility. Association of SLC11A1 with cutaneous leishmaniasis, a neglected tropical disease, is not well established. Inconsistencies have been observed within different populations worldwide with respect to genetic susceptibility...
January 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28052994/local-delivery-of-the-tlr9-ligand-cpg-down-regulates-host-immune-and-inflammatory-responses-ameliorating-established-leishmania-viannia-panamensis-chronic-infection
#6
Allison K Ehrlich, Olga L Fernández, Daniel Rodriguez-Pinto, Tiago M Castilho, Maria J Corral Caridad, Karen Goldsmith-Pestana, Nancy Gore Saravia, Diane McMahon-Pratt
Infection by Leishmania (Viannia) panamensis, the predominant etiologic agent for cutaneous leishmaniasis in Colombia, is characterized by a chronic mixed-inflammatory response. Current treatment options are plagued by toxicity, lengthy treatment regimens and growing evidence of drug resistance. Immunotherapy, modulating the immune system to mount a protective response, may provide an alternate therapeutic approach. We investigated the ability of the TLR9 ligand, CpG, to modulate established disease in the L...
January 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28043177/the-pulsed-dye-laser-is-more-effective-and-rapidly-acting-than-intralesional-meglumine-antimoniate-therapy-for-cutaneous-leishmaniasis
#7
Mohammad Radmanesh, Ehsan Omidian
BACKGROUND AND OBJECTIVE: The Pulsed dye laser (PDL) is not tested yet for the treatment of cutaneous leishmaniasis (CL). We compared the efficacy of 585nm PDL with intralesional meglumine antimoniate (MA) on 17 patients with 81 lesions of cutaneous leishmaniasis. PATIENTS AND METHOD: Out of the 81 lesions, 42 lesions were treated with one or two passes of PDL fortnightly and 39 lesions in the same patients were treated with intralesional MA weekly. The fluence chosen for the laser was 7 Joules/cm2 with 5mm spot size...
January 3, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28035115/aquaglyceroporin1-gene-expression-in-antimony-resistance-and-susceptible-leishmania-major-isolates
#8
Gilda Eslami, Morteza Vakil Zarchi, Alireza Moradi, Seyed Hossein Hejazi, Seyed Mojtaba Sohrevardi, Mahmoud Vakili, Ali Khamesipour
BACKGROUND & OBJECTIVES: The mechanism of antimony resistance in Leishmania has been studied extensively, in connection with decreased influx and/or increased eflux of the drug. Aquaporin 1 (AQP1) protein has been shown to mediate the uptake of trivalent antimony. This study was aimed to find the expression level of AQP1 gene in resistant versus non-resistant clinical isolates of Leishmania major in Iranian patients. METHODS: Clinical isolates were obtained from 16 considered patients referred to Navab Safavi Clinical Center, Isfahan, Iran from October 2014 to December 2015...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28035110/bioassay-evaluation-of-residual-activity-of-attractive-toxic-sugar-treated-barrier-fence-in-the-control-of-phlebotomus-papatasi-diptera-psychodidae
#9
Abedin Saghafipour, Hassan Vatandoost, Ali Reza Zahraei-Ramazani, Mohammad Reza Yaghoobi-Ershadi, Yavar Rassi, Mohammad Reza Shirzadi, Amir Ahmad Akhavan
BACKGROUND & OBJECTIVES: Phlebotomus papatasi is the main vector of the zoonotic cutaneous leishmaniasis (ZCL) in Qom Province and many other provinces of Iran. Attractive toxic sugar baits (ATSB) treated barrier fence is one of the new methods for controlling the vectors such as sandflies. The present study was designed to evaluate the residual activity of ATSB-treated barrier fence that was used in control of P. papatasi. METHODS: Following the selection of villages in Markazi district of Qom Province, central Iran during 2015 for ATSB and ASB (bait containing no active ingredient) methods; barrier fences on the ground in front of the rodent's colony were installed...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28032109/spatial-analyses-of-the-relation-between-rodent-s-active-burrows-and-incidence-of-zoonotic-cutaneous-leishmaniasis-in-golestan-province-northeastern-of-iran
#10
Aioub Sofizadeh, Hassan Vatandoost, Yavar Rassi, Ahmad Ali Hanafi-Bojd, Sayena Rafizadeh
BACKGROUND: Zoonotic cutaneous leishmaniasis (ZCL) is one of the most important vector-borne diseases in Iran. Wild Rodents play as a reservoir. The main aim of this study was to determine spatial analyses of the relationship between rodent's active burrows and Incidence of ZCL in Golestan Province, north east of Iran. METHODS: The cross-sectional study was conducted in 59 rural districts in Golestan Province. Spatial distribution of rodent's active burrows, human cases of ZCL and Incidence of disease were collected, using Geographical Information Systems (GIS)...
December 2016: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28032108/faunal-distribution-and-seasonal-bio-ecology-of-naturally-infected-sand-flies-in-a-new-endemic-zoonotic-cutaneous-leishmaniasis-focus-of-southern-iran
#11
Kourosh Azizi, Hayedeh Parvinjahromi, Mohammad Djaefar Moemenbellah-Fard, Bahador Sarkari, Mohammad Reza Fakoorziba
BACKGROUND: Cutaneous leishmaniasis is a major health problem in Iran in spite of implementation of control program. This infectious disease caused morbidity in less than 27000 people in 2010. This study was set to determine some ecological aspects of sand flies in Fasa district, Fars Province, southern Iran during 2011-2012. METHODS: A total of 4792 sand flies were captured by means of sticky paper and CDC miniature light traps in 10 selected villages from the beginning to the end of the active season, from which 1115 specimens were captured for abundance study and 3677 specimens captured for monitoring monthly activities in Fasa...
December 2016: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28032095/control-of-phlebotomine-sand-flies-in-iran-a-review-article
#12
REVIEW
Mohammad Reza Yaghoobi-Ershadi
Leishmaniasis has long been known as a significant public health challenge in many parts of Iran. Phlebotomus papatasi and P. sergenti are the vectors of Zoonotic Cutaneous Leishmaniasis and Anthroponotic Cutaneous Leishmaniasis respectively, and 5 species of sand flies including P. kandelakii, P. neglectus, P. perfiliewi, P. keshishiani and P. alexandri are considered as probable vectors of Zoonotic visceral leishmaniasis. A literature search was performed of the relevant multiple databases from 1966 to 2013 to include studies on sand flies, vector control, leishmaniasis, Phlebotomus...
December 2016: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28025245/predicting-the-distribution-of-phlebotomus-papatasi-diptera-psychodidae-the-primary-vector-of-zoonotic-cutaneous-leishmaniasis-in-golestan-province-of-iran-using-ecological-niche-modeling-comparison-of-maxent-and-garp-models
#13
Aioub Sofizadeh, Yavar Rassi, Hassan Vatandoost, Ahmad Ali Hanafi-Bojd, Abolfazl Mollalo, Sayena Rafizadeh, Amir Ahmad Akhavan
Zoonotic cutaneous leishmaniasis (ZCL) is a prevalent vector-borne disease in the Golestan province of Iran, with Phlebotomus papatasi (Scopoli, 1786) serving as the main vector. The aim of this study was to model the probability of presence of this species in the study area, and to determine the underlying factors affecting its distribution. Three villages were selected from each county of the province and visited monthly for investigating ZCL. Sticky paper traps were used for collecting the sand flies to determine the species present...
December 24, 2016: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28012931/disseminated-cutaneous-leishmaniasis-ulcerovegetative-and-ulcero-crusted-lesions
#14
Isabela Martins Sgarbi, Flávia da Silva Domingos Santos, Veridiana Elisa Monteiro, Silvia Nunes Szente Fonseca, Fred Bernardes Filho
No abstract text is available yet for this article.
December 21, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28011169/leishmanicidal-activity-of-the-alkaloid-rich-fraction-from-guatteria-latifolia
#15
C Ferreira, C L A Passos, D C Soares, K P Costa, M J C Rezende, A Q Lobão, A C Pinto, L Hamerski, E M Saraiva
Leishmaniasis is caused by protozoan parasites belonging to the genus Leishmania and includes cutaneous, mucocutaneous and visceral clinical forms. The drugs currently available for leishmaniasis treatment are pentavalent antimonials, amphotericin B and miltefosine, which present high toxicity, elevated cost and development of parasite resistance. The natural products constitute an important source of substances with leishmanicidal potential. Here we evaluated in vitro the anti-Leishmania amazonensis activity of crude extracts of branches, leaves and fruits of Guatteria latifolia...
December 21, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/28008252/nanoscaled-hydrated-antimony-v-oxide-as-a-new-approach-to-first-line-antileishmanial-drugs
#16
Antonia Mr Franco, Iryna Grafova, Fabiane V Soares, Gennaro Gentile, Claudia Dc Wyrepkowski, Marcos A Bolson, Ézio Sargentini, Cosimo Carfagna, Markku Leskelä, Andriy Grafov
BACKGROUND: Coordination compounds of pentavalent antimony have been, and remain, the first-line drugs in leishmaniasis treatment for >70 years. Molecular forms of Sb (V) complexes are commercialized as sodium stibogluconate (Pentostam(®)) and meglumine antimoniate (MA) (Glucantime(®)). Ever-increasing drug resistance in the parasites limits the use of antimonials, due to the low drug concentrations being administered against high parasitic counts. Sb(5+) toxicity provokes severe side effects during treatment...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28001228/standardization-of-intralesional-meglumine-antimoniate-treatment-for-cutaneous-leishmaniasis
#17
Maria Cristina de Oliveira Duque, Érica de Camargo Ferreira E Vasconcellos, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Sandro Javier Bedoya Pacheco, Mauro Celio de Almeida Marzochi, Cláudia Maria Valete Rosalino, Armando de Oliveira Schubach
INTRODUCTION: Intralesional treatment for cutaneous leishmaniasis has been applied for over 30 years at the Oswaldo Cruz Foundation, Rio de Janeiro, with good therapeutic results and without relevant systemic toxicity. METHODS: Meglumine antimoniate was injected subcutaneously, using a long medium-caliber needle (for example, 30mm × 0.8mm); patients received 1-3 injections, with 15-day intervals. RESULTS: The technique is described in detail sufficient to enable replication...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27999013/pharmacological-inhibition-of-p110%C3%AE-subunit-of-pi3k-confers-protection-against-experimental-leishmaniasis
#18
Forough Khadem, Ping Jia, Zhirong Mou, Aida Feiz Barazandeh, Dong Liu, Yoav Keynan, Jude E Uzonna
OBJECTIVES: This study aimed to evaluate the immuno-prophylactic and -therapeutic effect of p110δ-specific pharmacological inhibitors (CAL-101 and IC87114), either alone or in combination with amphotericin B, against experimental cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). METHODS: Female BALB/c mice were infected intravenously with Leishmania donovani or subcutaneously with Leishmania major Prophylactic treatment was initiated 24 h prior to infection, whereas therapeutic treatments with or without amphotericin B were initiated either 1 week or 2 weeks post-infection...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27990396/clinical-study-of-cutaneous-leishmaniasis-in-the-kashmir-valley
#19
Mahmood Dhahir Al-Mendalawi
No abstract text is available yet for this article.
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27988178/a-novel-protein-coding-potential-of-long-intergenic-non-coding-rnas-lincrnas-in-the-kinetoplastid-protozoan-parasite-leishmania-major
#20
Harsh Pawar, Kalpana Pai, Milind S Patole
Cutaneous leishmaniasis (CL) is caused by a kinetoplastid protozoan parasite Leishmania major, as a skin ulcer at the site of the sandfly bite. CL is curable and in most cases ulcers heal spontaneously within three to six months leaving a scar and disfiguration. Complete genome of L. major was reported in 2005 at the very initial phase of kinetoplastid parasite genome sequencing project. Presently, L. major genome is most studied and comprehensively annotated genome and therefore, it is being used as a reference genome for annotating recently sequenced Leishmanial genomes...
December 14, 2016: Acta Tropica
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