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cutaneous leishmaniasis

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https://www.readbyqxmd.com/read/29689488/solution-combustion-synthesis-of-doped-tio-2-compounds-and-its-potential-antileishmanial-activity-mediated-by-photodynamic-therapy
#1
A A Lopera, A M A Velásquez, L C Clementino, S Robledo, A Montoya, L M de Freitas, V D N Bezzon, C R Fontana, C Garcia, M A S Graminha
Photodynamic therapy has emerged as an alternative treatment for cutaneous leishmaniasis, and compounds with photocatalytic behavior are promising candidates to develop new therapeutic strategies for the treatment of this parasitic disease. Titanium dioxide TiO2 is a semiconductor ceramic material that shows excellent photocatalytic and antimicrobial activity under Ultraviolet irradiation. Due to the harmful effects of UV radiation, many efforts have been made in order to enhance both photocatalytic and antimicrobial properties of TiO2 in the visible region of the spectrum by doping or through modifications in the route of synthesis...
April 13, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29688342/why-funding-for-neglected-tropical-diseases-should-be-a-global-priority
#2
Sharon L Reed, James H McKerrow
Neglected Tropical Diseases affect more than 1 billion of the world's poorest people. Control programs range from near elimination (dracunculiasis) to increasing prevalence (dengue and cutaneous leishmaniasis). These are some of the most cost-effective public health interventions in the world and should be a global priority.
April 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29683289/antimicrobial-effects-of-photodynamic-therapy-an-overview
#3
Vanesa Pérez-Laguna, Ana J García-Malinis, Carmen Aspiroz, Antonio Rezusta, Yolanda Gilaberte
The microorganisms that cause infections are increasing their resistance to antibiotics. In this context, alternative treatments are necessary. The antimicrobial photodynamic therapy (aPDT) is a therapeutic modality based on photosensitizing molecules that end up generating reactive oxygen species that induce the destruction of the target cells when are irradiated with light of a suitable wavelength and at a proper dose. The cells targeted by aPDT are all types of microorganisms (bacteria, fungi and parasites) including viruses and has been proven effective against representative members of all of them...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29680937/intralesional-uridine-5-triphosphate-utp-treatment-induced-resistance-to-leishmania-amazonensis-infection-by-boosting-th-1-immune-responses-and-reactive-oxygen-species-production
#4
Camila Marques-da-Silva, Mariana M Chaves, Maria Luiza Thorstenberg, Vanessa R Figliuolo, Flávia S Vieira, Suzana P Chaves, José Roberto Meyer-Fernandes, Bartira Rossi-Bergmann, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva
Leishmania amazonensis is the etiologic agent of cutaneous leishmaniasis, an immune-driven disease causing a range of clinical symptoms. Infections caused by L. amazonensis suppress the activation and function of immune cells, including macrophages, dendritic cells, and CD4+ T cells. In this study, we analyzed the course of infection as well as the leishmanicidal effect of intralesional UTP treatment in L. amazonensis-infected BALB/c mice. We found that UTP treatment reduced the parasitic load in both footpad and lymph node sites of infection...
April 21, 2018: Purinergic Signalling
https://www.readbyqxmd.com/read/29675681/characterization-of-leishmania-species-from-central-west-region-of-brazil
#5
Ludiele Souza Castro, Adriana de Oliveira França, Eduardo de Castro Ferreira, Manoel Sebastião da Costa Lima Júnior, Célia Maria Ferreira Gontijo, Agnes Antônia Sampaio Pereira, Maria Elizabeth Cavalheiros Dorval
Leishmaniasis represents a complex of diseases with a broad clinical spectrum and epidemiological diversity. Involving a variety of agents, reservoirs, and vectors, cutaneous leishmaniasis (CL) presents different transmission patterns, which makes its control especially difficult. Epidemiological characterization with identification of existing Leishmania species in a particular region is essential for understanding this parasitosis epidemiology. Because similar results may be observed in places with overlapping transmission of visceral and cutaneous leishmaniasis, contributing to knowledge about the epidemiological cycle of cutaneous leishmaniasis is of global interest...
April 20, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29673889/comparative-efficacy-toxicity-and-biodistribution-of-the-liposomal-amphotericin-b-formulations-fungisome-%C3%A2-and-ambisome-%C3%A2-in-murine-cutaneous-leishmaniasis
#6
Gert-Jan Wijnant, Katrien Van Bocxlaer, Vanessa Yardley, Andy Harris, Mo Alavijeh, Rita Silva-Pedrosa, Sandra Antunes, Isabel Mauricio, Sudaxshina Murdan, Simon L Croft
Fungisome® (F), a liposomal amphotericin B (AmB) product, is marketed in India as a safe and effective therapeutic for the parasitic infection visceral leishmaniasis. Its potential in the treatment of cutaneous leishmaniasis (CL), a disfiguring form of the disease affecting the skin, is currently unknown. Here, we report the evaluation of the efficacy of F in the Leishmania major BALB/c murine model of CL, including a head-to-head comparison with the standard liposomal AmB formulation AmBisome® (A). Upon intravenous administration at dose levels of 5, 10 and 15 mg/kg of body weight (on days 0, 2, 4, 6 and 8), F showed clear signs of toxicity (at 15 mg/kg), while A did not...
April 12, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29670621/integrated-analysis-reveals-that-mir-193b-mir-671-and-trem-1-correlate-with-a-good-response-to-treatment-of-human-localized-cutaneous-leishmaniasis-caused-by-leishmania-braziliensis
#7
Sara Nunes, Icaro Bonyek Silva, Mariana Rosa Ampuero, Almério Libório Lopes de Noronha, Lígia Correia Lima de Souza, Thaizza Cavalcante Correia, Ricardo Khouri, Viviane Sampaio Boaventura, Aldina Barral, Pablo Ivan Pereira Ramos, Cláudia Brodskyn, Pablo Rafael Silveira Oliveira, Natalia Machado Tavares
Localized cutaneous leishmaniasis (LCL) is a chronic disease characterized by ulcerated skin lesion(s) and uncontrolled inflammation. The mechanisms underlying the pathogenesis of LCL are not completely understood, and little is known about posttranscriptional regulation during LCL. MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and can be implicated in the pathogenesis of LCL. We investigated the involvement of miRNAs and their targets genes in human LCL using publicly available transcriptome data sets followed by ex vivo validation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29668138/-molecular-typing-of-leishmania-leishmania-amazonensis-and-species-of-the-subgenus-viannia-associated-with-cutaneous-and-mucosal-leishmaniasis-in-colombia-a-concordance-study
#8
Clemencia Ovalle-Bracho, Carolina Camargo, Yira Díaz-Toro, Marcela Parra-Muñoz
INTRODUCTION: Multilocus enzyme electrophoresis (MLEE) is the reference standard for the characterization of Leishmania species. The test is restricted to specialized laboratories due to its technical complexity, cost, and time required to obtain results. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is used to identify Leishmania species. OBJECTIVE: To establish the concordance between the two tests as identifying methods for circulating species in Colombia...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29665825/evaluation-of-fluorimetry-and-direct-visualization-to-interpret-results-of-a-loop-mediated-isothermal-amplification-kit-to-detect-leishmania-dna
#9
Ana V Ibarra-Meneses, Israel Cruz, Carmen Chicharro, Carmen Sánchez, Sylvain Biéler, Tobias Broger, Javier Moreno, Eugenia Carrillo
BACKGROUND: Nucleic acid amplification tests (NAATs) have proven to be advantageous in the diagnosis of leishmaniases, allowing sensitive diagnosis of: (i) cutaneous leishmaniasis in long duration lesions and (ii) visceral leishmaniasis using a less-invasive sample like peripheral blood, in opposition to tissue aspiration required for parasite demonstration by microscopy. Despite their benefits, the implementation of NAATs for leishmaniasis diagnosis at the point-of-care has not been achieved yet, mostly due to the complexity and logistical issues associated with PCR-based methods...
April 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29663351/clinical-practice-guidelines-for-the-diagnosis-and-treatment-of-cutaneous-leishmaniasis-in-turkey
#10
Soner Uzun, Mehmet S Gürel, Murat Durdu, Melih Akyol, Bilge Fettahlıoğlu Karaman, Mustafa Aksoy, Sema Aytekin, Murat Borlu, Esra İnan Doğan, Çiğdem Asena Doğramacı, Yelda Kapıcıoğlu, Ayşe Akman-Karakaş, Tamer I Kaya, Mehmet K Mülayim, Yusuf Özbel, Seray Özensoy Töz, Orhan Özgöztaşı, Yavuz Yeşilova, Mehmet Harman
BACKGROUND: Cutaneous leishmaniasis (CL) is a vector-born parasitic disease characterized by various skin lesions that cause disfiguration if healed spontaneously. Although CL has been endemic for many years in the southern regions of Turkey, an increasing incidence in nonendemic regions is being observed due to returning travelers and, more recently, due to Syrian refugees. Thus far, a limited number of national guidelines have been proposed, but no common Turkish consensus has emerged...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29655887/engineering-riboswitch-in-l-major-from-prediction-to-conceptualization
#11
Pruthvi Raj Bejugam, Shailza Singh
Post-transcriptional gene regulation is a vital process to regulate expression of the key genes in the eukaryotic cell. Such processes are essential for pathogens which reside inside the host cell. One such pathogen is Leishmania major, which causes cutaneous leishmaniasis. The parasite lives inside the macrophages of mammalian host (mostly human). Inside the macrophage, Leishmania genes show complex host-pathogen interaction regulating a plethora of gene expression. Till date, most of the studies have shown this kind of regulation with respect to the host macrophages...
April 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29655615/locked-nucleic-acid-anti-let-7a-induces-apoptosis-and-necrosis-in-macrophages-infected-with-leishmania-major
#12
Nooshin Hashemi, Mohammadreza Sharifi, Mohsen Masjedi, Sepideh Tolouei, Mitra Hashemi, Nahid Mortazavidehkordi, Mohammad Ali Mohaghegh, Cyrus Hashemi, Seyed Hossein Hejazi
BACKGROUND: Protozoan parasites of the genus Leishmania are etiologic agents which are intracellular pathogens of vertebrates and replicate inside infected macrophages. Leishmania have developed complex strategies to reverse host immune responses in favor of it. One of the major species causing cutaneous involvements is Leishmania major. MicroRNAs (miRNA) are non-coding small RNAs encoding 22-nucleotide (nt) long RNAs. miRNAs affect diverse biological processes, including cell cycle, proliferation, differentiation, growth and development, metabolism, aging, apoptosis, gene expression and immune regulation...
April 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29649772/enhancement-of-th1-immune-response-against-leishmania-cysteine-peptidase-a-b-by-plga-nanoparticle
#13
H Noormehr, A Zavaran Hosseini, S Soudi, F Beyzay
Recombinant cysteine peptidase vaccine can induce protective immunity against cutaneous leishmaniasis. However, the antigenic diversity and variable immunogenicity prevents them from being approved for general vaccination. Different approaches like adjuvant application and antigen delivery systems are studied to increase their efficacy. Nanoparticles can both stimulated antigen uptakes and affect direction of immune response. In this study the effect of PLGA nanoparticles were considered to enhance the immune response against recombinant CPA (CPA) and CPB (CPB)...
April 9, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29645094/leishmania-amazonensis-downregulates-macrophage-inos-expression-via-histone-deacetylase-1-hdac1-a-novel-parasite-evasion-mechanism
#14
Teresa C Calegari-Silva, Áislan C Vivarini, Renata de M S Pereira, Karina L Dias-Teixeira, Carolina T Rath, Amanda S S Pacheco, Gabrielle B L Silva, Charlene A S Pinto, José V Dos Santos, Alessandra M Saliba, Carlos E P Corbett, Claudia M de Castro Gomes, Nicolas Fasel, Ulisses G Lopes
The induced expression of nitric oxide synthase (iNOS) controls the intracellular growth of Leishmania in infected macrophages. Histones deacetylases (HDACs) negatively regulate gene expression through the formation of complexes containing transcription factors such as NF-κB p50/50. Herein, we demonstrated the occupancy of p50/p50_HDAC1 to iNOS promoter associated with reduced levels of H3K9Ac. Remarkably, we found increased levels of HDAC1 in L. amazonensis-infected macrophages. HDAC1 upregulation was not found in L...
April 12, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29642944/concomitant-visceral-and-localized-cutaneous-leishmaniasis-in-two-moroccan-infants
#15
Tarik Mouttaki, Hasnaa Maksouri, Jilali El Mabrouki, Gema Merino-Espinosa, Hassan Fellah, Mohamed Itri, Joaquina Martin-Sanchez, Maha Soussi-Abdallaoui, Soumiya Chiheb, Myriam Riyad
BACKGROUND: Leishmaniases are vector-borne diseases caused by the protozoa of the Leishmania genus. The clinical spectrum of these diseases extends from benign dermal lesions to visceral forms. In the Mediterranean region, zoonotic visceral leishmaniasis (ZVL) is caused by L. infantum. If untreated within two years, the disease usually leads to death. In Morocco, ZVL is endemic in the north, with a hundred cases notified each year, mostly in children aged below five years. Here, we report on two clinical observations in infants presenting unusual concomitant VL and cutaneous leishmaniasis (CL) in Morocco...
April 12, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29642829/-infecting-glial-cells-with-antimony-resistant-leishmania-tropica-a-new-ex-vivo-model
#16
Orçun Zorbozan, Mehmet Harman, Vedat Evren, Mümin Alper Erdoğan, Aslı Kılavuz, Varol Tunalı, İbrahim Çavuş, Özlem Yılmaz, Ahmet Özbilgin, Nevin Turgay
Leishmaniasis is a vector-borne zoonotic disease that shows different clinical features like cutaneous, mucocutaneous, visceral and viscerotropic forms. The protocols used in the treatment of leishmaniasis are toxic and have many limitations during administration. One of the limitations of treatment is the resistance against the protocols in practice. There is also a need to define new treatment options especially for resistant patients. Ex-vivo models using primary cell cultures may be a good source for evaluating new drug options in patients with antimony resistance, in addition to in-vitro and in-vivo studies...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29624912/antichagasic-leishmanicidal-and-trichomonacidal-activity-of-2-benzyl-5-nitroindazole-derived-amines
#17
Vicente J Aran, Cristina Fonseca-Berzal, Alexandra Ibáñez-Escribano, Nerea Vela, José Cumella, Juan José Nogal-Ruiz, José Antonio Escario, Patrícia Bernardino da Silva, Marcos Meuser Batista, Maria de Nazaré C Soeiro, Sergio Sifontes-Rodriguez, Alfredo Meneses-Marcel, Alicia Gómez-Barrio
Three different series of new 5-nitroindazole derivatives, 1-(ω-aminoalkyl)-2-benzylindazolin-3-ones (series A; 10 compounds), 3-(ω-aminoalkoxy)-2-benzylindazoles (series B; 4 compounds) and 3-alkylamino-2-benzylindazoles (series C; 5 compounds), have been synthesized and evaluated against the protozoan parasites Trypanosoma cruzi, Leishmania amazonensis and Trichomonas vaginalis, etiological agents of Chagas disease, cutaneous leishmaniasis and trichomoniasis, respectively. Many indazoles of series A, B and C were efficient against T...
April 6, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29624586/hidden-danger-unexpected-scenario-in-the-vector-parasite-dynamics-of-leishmaniases-in-the-brazil-side-of-triple-border-argentina-brazil-and-paraguay
#18
Vanete Thomaz-Soccol, André Luiz Gonçalves, Claudio Adriano Piechnik, Rafael Antunes Baggio, Walter Antônio Boeger, Themis Leão Buchman, Mario Sergio Michaliszyn, Demilson Rodrigues Dos Santos, Adão Celestino, José Aquino, André de Souza Leandro, Otacílio Lopes de Souza da Paz, Marcelo Limont, Alceu Bisetto, Jeffrey Jon Shaw, Zaida Estela Yadon, Oscar Daniel Salomon
Every year about 3 million tourists from around the world visit Brazil, Argentina and Paraguay´s triple border region where the Iguaçu Falls are located. Unfortunately, in recent years an increasing number of autochthonous canine and human visceral leishmaniosis (VL) cases have been reported. The parasite is Leishmania (Leishmania) infantum and it is transmitted by sand flies (Phlebotominae). To assess the risk factors favorable for the establishment and spread of potential vectors the Centers for Disease Control and Prevention light trap (CDC-light trap) collections were made in the Foz do Iguaçu (FI) and Santa Terezinha de Itaipu (STI) townships and along two transects between them...
April 6, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29618227/improved-drug-loading-via-spray-drying-of-a-chalcone-implant-for-local-treatment-of-cutaneous-leishmaniasis
#19
Ariane J Sousa-Batista, Natalia Arruda-Costa, Bartira Rossi-Bergmann, Maria Inês Ré
Current chemotherapy of cutaneous leishmaniasis (CL), even the mildest forms, encompasses multiple and painful injections with toxic drugs that cause systemic adverse effects. Recently, we showed the promising use of PLGA microparticles loaded with an antileishmanial nitrosylated chalcone (CH8) for effective, safe, local and single-dose treatment of CL. Here, we proposed to optimize the delivery system by increasing the CH8 loading in PLGA-microparticles using spray drying instead of emulsification-solvent evaporation...
April 5, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29608175/quantification-of-intracellular-growth-inside-macrophages-is-a-fast-and-reliable-method-for-assessing-the-virulence-of-leishmania-parasites
#20
Amrita Sarkar, Yousuf A Khan, Maria Fernanda Laranjeira-Silva, Norma W Andrews, Bidyottam Mittra
The lifecycle of Leishmania, the causative agent of leishmaniasis, alternates between promastigote and amastigote stages inside the insect and vertebrate hosts, respectively. While pathogenic symptoms of leishmaniasis can vary widely, from benign cutaneous lesions to highly fatal visceral disease forms depending on the infective species, all Leishmania species reside inside host macrophages during the vertebrate stage of their lifecycle. Leishmania infectivity is therefore directly related to its ability to invade, survive and replicate within parasitophorous vacuoles (PVs) inside macrophages...
March 16, 2018: Journal of Visualized Experiments: JoVE
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