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cutaneous leishmaniasis

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https://www.readbyqxmd.com/read/29451599/first-case-report-of-atypical-disseminated-cutaneous-leishmaniasis-in-an-opium-abuser-in-iran
#1
Seyed Ahmad Hashemi, Alireza Badirzadeh, Sadaf Sabzevari, Ali Nouri, Mohammad Seyyedin
Leishmaniasis is a worldwide tropical infectious disease caused by different species of intracellular protozoa parasites of the genus Leishmania . Herein, we report a 78-year-old man with unusual diffuse cutaneous leishmaniasis (DCL) who had a history of opium abuse and chronic obstructive pulmonary disease (COPD). He had multiple papular, crusted and severely ulcerated lesions extended to his arm and chest. Direct smears and skin punch biopsy of the lesions were suggestive of leishmaniasis. Parasite DNA was amplified from ulcers, and identified as Leishmania major by PCR-RFLP, confirmed by sequencing analyses...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29451596/histopathological-characteristics-of-cutaneous-lesions-caused-by-leishmania-viannia-panamensis-in-panama
#2
Kadir González, Rosendo Diaz, Aurea F Ferreira, Víctor García, Héctor Paz, José E Calzada, Michelle Ruíz, Márcia Laurenti, Azael Saldaña
Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V.) panamensis in Panama...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29449723/an-outbreak-of-cutaneous-leishmaniasis-in-modena-province-northern-italy-report-of-35-cases
#3
A M Cesinaro, S Nosseir, E Mataca, M C Mengoli, C Cavatorta, W Gennari
Canine Leishmaniasis is a disease endemic in many parts of Europe, carried by insects of phlebotomous species. Humans are occasional hosts of the parasites. Cases of human leishmaniasis have been registered in Italy, particularly in the southern and coastal regions. In the period 1997-2016, we collected a series of 35 patients affected by cutaneous leishmaniasis, uncovered by skin biopsy and histological examination, 21 of them found in last 3 years. The patients, 28 males and 7 female, aged between 19 and 91, resided in a restricted area of Northern Italy, and none, but two, had travelled abroad...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29446852/isolation-of-crithidia-spp-from-lesions-of-immunocompetent-patients-with-suspected-cutaneous-leishmaniasis-in-iran
#4
Nafiseh Ghobakhloo, Mohammad Hossei Motazedian, S Naderi, Ebrahimi Sepideh
OBJECTIVE: Leishmania major has been considered as the main etiological agent of cutaneous leishmaniasis in Iran. However, there are recent reports about existence of Crithidia spp in cutaneous lesions in southern Iran. Therefore, this study was designed to decipher some morphological, biological, and molecular aspects of this phenomenon. METHODS: Clinical isolates were obtained from 167 patients with cutaneous ulcers. A set of specific primers based on GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) gene were used to distinguish between Crithidia and Leishmania genera...
February 15, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29444705/health-economic-evaluation-of-moist-wound-care-in-chronic-cutaneous-leishmaniasis-ulcers-in-afghanistan
#5
Hans-Christian Stahl, Faridullah Ahmadi, Sami Mohammad Nahzat, Heng-Jin Dong, Kurt-Wilhelm Stahl, Rainer Sauerborn
BACKGROUND: The present health economic evaluation in Afghanistan aims to support public health decision makers and health care managers to allocate resources efficiently to appropriate treatments for cutaneous leishmaniasis (CL) elicited by Leishmania tropica or Leishmania major. METHODS: A decision tree was used to analyse the cost and the effectiveness of two wound care regimens versus intra-lesional antimony in CL patients in Afghanistan. Costs were collected from a societal perspective...
February 14, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29440688/unbalanced-inflammatory-reaction-could-increase-tissue-destruction-and-worsen-skin-infectious-diseases-a-comparative-study-of-leishmaniasis-and-sporotrichosis
#6
F N Morgado, L M V de Carvalho, J Leite-Silva, A J Seba, M I F Pimentel, A Fagundes, M F Madeira, M R Lyra, M M Oliveira, A O Schubach, F Conceição-Silva
The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438445/crispr-cas9-in-leishmania-mexicana-a-case-study-of-lmxbtn1
#7
Aygul Ishemgulova, Jana Hlaváčová, Karolina Majerová, Anzhelika Butenko, Julius Lukeš, Jan Votýpka, Petr Volf, Vyacheslav Yurchenko
Leishmania parasites cause human cutaneous, mucocutaneous and visceral leishmaniasis. Several studies proposed involvement of certain genes in infectivity of these parasites based on differential mRNA expression data. Due to unusual gene expression mechanism, functions of such genes must be further validated experimentally. Here, we investigated a role of one of the putative virulence factors, LmxM.22.0010-encoded BTN1 (a protein involved in Batten disease in humans), in L. mexicana infectivity. Due to the incredible plasticity of the L...
2018: PloS One
https://www.readbyqxmd.com/read/29427273/climate-and-environmental-factors-affecting-the-incidence-of-cutaneous-leishmaniasis-in-isfahan-iran
#8
Roghieh Ramezankhani, Nooshin Sajjadi, Roya Nezakati Esmaeilzadeh, Seyed Ali Jozi, Mohammad Reza Shirzadi
Cutaneous leishmaniasis (CL) is a vector-borne human disease caused by Leishmania, a parasite transmitted by sand flies. CL is endemic in the Isfahan Province, Iran. This study was designed to identify the climate and environmental factors associated with CL incidence in Isfahan Province. Data included incident cases of CL, climate, and environmental factors, which were collected across 23 districts of province from 2007 to 2015. Analyses were performed with generalized linear models (GLMs) to fit a function to the relationships between the response and predictors...
February 9, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29425540/-when-to-ask-for-a-skin-biopsy-in-a-patient-with-leg-ulcer-retrospective-study-of-143-consecutive-biopsies
#9
A Stansal, K Khayat, V Duchatelle, E Tella, V Gautier, D Sfeir, R Attal, I Lazareth, P Priollet
OBJECTIVE: A vascular cause is found in around 85% of leg ulcer patients, but non-vascular causes are also observed. Their diagnosis is based on a set of clinical arguments and skin biopsy with histological analysis. The aim of this study was to analyze the results of these biopsies and to find common criteria for ulcers whose skin biopsies had led to the diagnosis of a non-vascular ulcer. MATERIAL AND METHOD: A retrospective study was carried out on the analysis of 143 skin biopsies of leg ulcers...
February 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29424815/successful-treatment-of-disseminated-cutaneous-leishmaniasis-with-liposomal-amphotericin-b-and-miltefosine-in-an-eight-year-old-girl
#10
Seyedeh Sedigheh Hamzavi, Anahita Sanaei Dashti, Mohammad Rahim Kadivar, Gholamreza Pouladfar, Bahman Pourabbas
This case report presents an 8-year-old girl, from Fars province in Iran, diagnosed with cutaneous leishmaniasis in the form of multiple nodular, ulcerative and crusted lesions disseminated on the face, trunk and extremities. The result of direct smear of ulcers was positive for Leishmania parasite. The patient had no immunodeficiency or relevant family history making her susceptible for disseminated cutaneous leishmaniasis. The skin lesions failed to respond to multiple treatment courses of meglumine antimoniate or amphotericin B but were successfully treated with simultaneous miltefosine and liposomal amphotericin B...
March 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29415246/cutaneous-leishmaniasis-in-the-metropolitan-city-of-multan-pakistan-a-neglected-tropical-disease
#11
Muhammad Mazhar Ayaz, Muhammad Mudasser Nazir, Najeeb Ullah, Aqil Zaman, Atif Akbar, Muhammad Zeeshan, Zahid Hussain, Saima Naz, Yadong Zheng, Asghar Javed, David S Lindsay
Cutaneous leishmaniasis is a vector-borne infection caused by flagellated parasitic protozoans in the genus Leishmania. Promastigotes are the infective stage, which are transmitted by the bite of female sand flies of the genera Phlebotomus or Lutzomyia. Three clinical forms of Leishmania infection are recognized in humans, and they are caused by different Leishmania species. They are cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (ML), and visceral leishmaniasis (VL). Up to 2 million cases of leishmaniasis are reported annually worldwide...
February 5, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29415078/risk-factors-for-anthroponotic-cutaneous-leishmaniasis-in-unresponsive-and-responsive-patients-in-a-major-focus-southeast-of-iran
#12
Mehdi Bamorovat, Iraj Sharifi, Mohammad Reza Aflatoonian, Hamid Sharifi, Ali Karamoozian, Fatemeh Sharifi, Ahmad Khosravi, Saeid Hassanzadeh
Cutaneous leishmaniasis (CL) is a serious health challenge at the global level due to Leishmania tropica. This study was conducted to evaluate the risk factors associated with anthroponotic CL (ACL) in unresponsive (patient who does not heal and remains with an active lesion, despite receiving two courses of intra-lesional Glucantime along with cryotherapy and one cycle of systemic Glucantime) and responsive patients in a major focus in southeastern Iran. A case-control study was conducted from April 2015 to October 2016 in the southeast of Iran...
2018: PloS One
https://www.readbyqxmd.com/read/29413886/first-detection-of-leishmania-dna-in-psammomys-obesus-and-psammomys-vexillaris-their-potential-involvement-in-the-epidemiology-of-leishmaniasis-in-tunisia
#13
Souad Ben Othman, Wissem Ghawar, Melek Chaouch, Chiraz Ayari, Jomaa Chemkhi, Beatriz Cancino-Faure, Miriam Tomás-Pérez, Maria Magdalena Alcover, Cristina Riera, Afif Ben Salah, Roser Fisa, Riadh Ben Ismail, Souha Ben Abderrazak
Leishmaniasis, a public health problem in Tunisia, are diseases caused by different Leishmania species. Cutaneous leishmaniasis is present from the North to the South under different forms, due to Leishmania (L.) major, L. infantum or L. tropica. Whereas, Psammomys (P.) obesus is the confirmed reservoir host of L. major, those of L. tropica and dermotropic L. infantum wait to be identified. Importantly, P. vexillaris species have been recently highlighted; however, no studies have been carried out to explore its potential role in leishmaniasis epidemiology...
January 29, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29412360/lutzomyia-umbratilis-from-an-area-south-of-the-negro-river-is-refractory-to-in-vitro-interaction-with-leishmania-guyanensis
#14
Rodrigo Pedro Soares, Paula Monalisa Nogueira, Nágila Francinete Secundino, Eric Fabrício Marialva, Cláudia Maria Ríos-Velásquez, Felipe Arley Costa Pessoa
BACKGROUND: Lutzomyia umbratilis, the vector for Leishmania guyanensis in northern South America, has been found naturally infected with L. guyanensis only in areas north of the Negro and Amazon rivers. While populations of this sand fly species are also found in areas south of these rivers, these populations have never been reported to be infected and/or transmitting L. guyanensis. However, no studies on the corresponding host-parasite interactions are available. OBJECTIVES: This study evaluated the interaction between Lu...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412341/leishmania-viannia-braziliensis-isolated-from-the-saliva-of-patients-in-a-cutaneous-leishmaniasis-endemic-area-of-northeastern-brazil
#15
Maria Edileuza Felinto de Brito, Ericka Lima Almeida, Angela Cristina Rapela Medeiros, Roberto Pereira Werkhäuser, Joanna Lucia de Almeida Alexandre, Bruna Santos Lima Figueiredo Sá, Eduardo Henrique Gomes Rodrigues, Sinval Pinto Brandão-Filho
Several studies have described the use of non-invasive collection methods, mostly based on the detection of parasite DNA, for diagnosis. However, no Leishmania specimens have been isolated from saliva. Here, we report the first isolation of Leishmania braziliensis from the saliva of humans with cutaneous leishmaniasis but without lesions on their mucosa. The isolates were obtained from salivary fluid inoculated in hamsters and were tested by multilocus enzyme electrophoresis. Seven samples from 43 patients suspected of having the disease were identified for in vivo culture...
February 5, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29405108/regulatory-t-cell-dynamics-in-cutaneous-and-mucocutaneous-leishmaniasis-due-to-leishmania-braziliensis
#16
Nicolas Barros, Nestor Vasquez, Fernando Woll, Cesar Sanchez, Braulio Valencia, Alejandro Llanos-Cuentas, A Clinton White, Martin Montes
To evaluate the dynamics of regulatory T cells (Tregs) during tegumentary leishmaniasis, we assessed peripheral blood and biopsies from 54 patients. Patients with cutaneous leishmaniasis (CL) had a decreased proportion of Tregs in the peripheral blood, but the proportion was higher in the biopsies of lesions. During treatment of CL, circulating Tregs increased reaching normal proportions, whereas antigen-specific interferon-γ responses diminished. By contrast, circulating Tregs from mucosal leishmaniasis patients failed to normalize during treatment...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29403630/an-overview-of-skin-lesions-adapted-to-cutaneous-leishmaniasis-in-persian-medicine
#17
REVIEW
Masoud Maleki, Mahdi Yousefi, Sayyed Mojtaba Mousavi Bazzaz, Sayyed Abolghasem Sajadi Tabassi, Hasan Rakhshandeh, Shokouh Sadat Hamedi, Gholamreza Haghighi
Background: Cutaneous Leishmaniasis (CL) which is prevalent in all continents and is classified by the WHO as one of the neglected tropical diseases, existed in the past also, and discovered ancient works confirm this issue. The lack of adaptation of diseases between Persian Medicine (PM) and Modern medicine, led to no usage of effective therapeutic experiences of prior physicians. Objective: The purpose of this study is finding skin lesions adapted to CL in PM for usage of same disease treatment in the next clinical trials, and the use of approved therapies in CL...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29392995/leishmania-major-cutaneous-leishmaniasis-outbreak-in-the-jordanian-side-of-the-northern-jordan-valley
#18
Ibrahim M Mosleh, Gabrielle Schönian, Khalil Kanani, Bassam Shadfan
Cutaneous leishmaniasis (CL) is endemic in many foci of Jordan and the Jordanian Mid Jordan Valley (JMJV) is the most affected and the incidence is quite high. The situation in the northern part of the Jordanian side of the Jordan Valley (NJJV) was different; before 2008, CL has rarely been reported from this area. From April 2008 to May 2009, passive detection followed by active detection was used to trace cases of CL from the NJJV. DNA was extracted from seven clinical isolates of Leishmania promastigotes and lesion scrapings spotted on filter papers obtained from 51 suspected CL patients living in the NJJV...
February 2, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29385497/geospatial-and-climatic-patterns-associated-with-the-distribution-of-sand-fly-diptera-psychodidae-vectors-of-leishmaniasis-in-pakistan
#19
Khurshaid Khan, Sobia Wahid, Nazma Habib Khan, Safeer Ullah Shah, Bakht Sarwar, Naheed Ali
We provide a comprehensive and updated review on the effects of elevation and climatic factors on distribution of sand fly (Diptera: Psychodidae) vectors of cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) across Pakistan. Our study was undertaken in view of the increasing risk of leishmaniasis, particularly resulting from climatic deviations and political instability in the region. Literature (published and unpublished) on suspected vectors of CL (Phlebotomus sergenti Parrot and Phlebotomus papatasi Scopoli) and VL (Phlebotomus major Yakimoff and Schokhor and Phlebotomus hindustanicus Theodor) was collected, sorted, and utilized in geospatial analysis...
January 27, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29381573/visceral-and-cutaneous-leishmaniasis-recommendations-for-solid-organ-transplant-recipients-and-donors
#20
Wanessa Trindade Clemente, Paulo Henrique Orlandi Mourão, Francisco Lopez-Medrano, Brian S Schwartz, Carmen García-Donoso, Julian Torre-Cisneros
No abstract text is available yet for this article.
February 2018: Transplantation
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