keyword
MENU ▼
Read by QxMD icon Read
search

cutaneous leishmaniasis

keyword
https://www.readbyqxmd.com/read/28820714/epidemiology-of-cutaneous-leishmaniasis-in-a-colombian-municipality
#1
Diego Alejandro Medina-Morales, Manuel E Machado-Duque, Jorge Enrique Machado-Alba
This study describes the epidemiological and clinical characteristics of leishmaniasis and the pharmacological treatment of this disease in the municipality of Pueblo Rico, Risaralda, between January 2010 and December 2014. An observational study was conducted using information from the clinical records and epidemiological reports of patients diagnosed and confirmed with leishmaniasis of any age and sex, including sociodemographic, clinical, and pharmacological variables of the therapy received. Univariate and bivariate analyses were performed...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820681/efficacy-safety-and-cost-effectiveness-of-thermotherapy-in-the-treatment-of-leishmania-donovani-induced-cutaneous-leishmaniasis-a-randomized-controlled-clinical-trial
#2
Wardha F Refai, Nayani P Madarasingha, Buthsiri Sumanasena, Sudath Weerasingha, Amala De Silva, Rohini Fernandopulle, Abhay R Satoskar, Nadira D Karunaweera
Leishmania donovani causes cutaneous leishmaniasis (CL) in Sri Lanka. Standard treatment is multiple, painful doses of intralesional sodium stibogluconate (IL-SSG). Treatment failures are increasingly reported, hence the need to investigate alternatives. Efficacy, safety, and cost-effectiveness of thermotherapy were assessed for the first time for L. donovani CL. A single blinded noninferiority randomized controlled trial was conducted on new laboratory-confirmed CL patients with single lesions (N = 213). Selected patients were randomly assigned to 1) test group (N = 98; single session of radiofrequency-induced heat therapy (RFHT) given at 50°C for 30 seconds) and 2) control group (N = 115; 1-3 mL IL-SSG given weekly, until cure/10 doses)...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820339/emergence-of-visceral-leishmaniasis-in-sri-lanka-a-newly-established-health-threat
#3
H V Y D Siriwardana, P Karunanayake, L Goonerathne, N D Karunaweera
BACKGROUND: Sri Lanka is a new focus of human cutaneous leishmaniasis caused by a genetic variant of usually visceralizing parasite Leishmania donovani. Over 3000 cases have been reported to our institution alone, during the past two decades. Recent emergence of visceral leishmaniasis is of concern. METHODS: Patients suspected of having visceral leishmaniasis (n = 120) fulfilling at least two of six criteria (fever > 2 weeks, weight loss, tiredness affecting daily functions, splenomegaly, hepatomegaly and anemia) were studied using clinic-epidemiological, immunological and haematological parameters...
August 18, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28811000/a-case-of-cutaneous-leishmaniasis-guyanensis-mimicking-otitis-externa
#4
Eric S Goodrich, Stephen C Sears, Timothy Sorrells, James K Radike, Anis Miladi, Jonathan S Glass
Cutaneous leishmaniasis typically presents as a painless papule progressing to an ulcer or plaque. In this case study of the ear, the disease manifested as a small painful bump progressing into redness and swelling about the ear with purulent drainage. After multiple oral/intravenous antipseudomonal, antistaphylococcal, and antifungal treatments, there was no improvement. The skin progressed to an erythematous plaque and hemorrhagic ulcer; punch biopsy and speciation revealed Leishmaniasis guyanensis. The patient was switched to a seven-dose course of intravenous L-amphotericin B (visceral leishmaniasis protocol)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810997/cutaneous-leishmaniasis-in-a-saudi-arabian-soldier-stationed-in-the-united-states
#5
Kelly Laurent, Jason Susong, Eric Fillman, Simon Ritchie
BACKGROUND: Leishmaniasis is a common parasitic disease seen in many parts of the world, especially in areas where current U.S. and international forces are deployed. Approximately 350 million people are thought to be at risk of cutaneous leishmaniasis (CL) with an annual incidence of 1.5 million cases. Over 90% of cutaneous infections with Leishmania occur in the Middle East, Brazil, and Peru. Outbreaks of CL may occur in military personnel deployed to endemic areas. Since the incubation period for symptomatic CL ranges from weeks to months, symptoms may not appear until well after returning to the United States...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28806141/cutaneous-leishmaniasis-in-saudi-arabia-a-comprehensive-overview
#6
Abuzaid A Abuzaid, Abdalmohsin M Abdoon, Mohamed A Aldahan, Abdullah G Alzahrani, Raaft F Alhakeem, Abdullah M Asiri, Mohamed H Alzahrani, Ziad A Memish
Despite the great efforts by health authorities in Kingdom of Saudi Arabia (KSA), Cutaneous Leishmaniasis (CL) continues to be a major public health problem in the country. Many risk factors make KSA prone to outbreaks and epidemics; among these, rapid urbanization and the huge population movement are the most important. The disease is endemic in many parts of KSA, with the majority of cases concentrated in six regions, including Al-Qaseem, Riyadh, Al-Hassa, Aseer, Ha'il, and Al-Madinah. Leishmania major (L...
August 14, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28798144/frontline-science-leishmania-mexicana-amastigotes-can-replicate-within-neutrophils
#7
Benjamin P Hurrell, Manon Beaumann, Sandrina Heyde, Ivo B Regli, Andreas J Müller, Fabienne Tacchini-Cottier
Cutaneous leishmaniasis is a neglected tropical disease, causing a spectrum of clinical manifestations varying from self-healing to unhealing lesions that may be very difficult to treat. Emerging evidence points to a detrimental role for neutrophils during the first hours following infection with many distinct Leishmania species (spp.) at a time when the parasite is in its nonreplicative promastigote form. Neutrophils have also been detected at later stages of infection in unhealing chronic cutaneous lesions...
August 10, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28796786/phlebotomine-sand-fly-borne-pathogens-in-the-mediterranean-basin-human-leishmaniasis-and-phlebovirus-infections
#8
REVIEW
Martina Moriconi, Gianluca Rugna, Mattia Calzolari, Romeo Bellini, Alessandro Albieri, Paola Angelini, Roberto Cagarelli, Maria P Landini, Remi N Charrel, Stefania Varani
Pathogens transmitted to humans by phlebotomine sand flies are neglected, as they cause infectious diseases that are not on the priority list of national and international public health systems. However, the infections caused by protozoa of the Leishmania genus and viruses belonging to the Phlebovirus genus (family Phenuiviridae)-the most significant group of viruses transmitted by sand flies-have a relevant role for human pathology. These infections are emerging in the Mediterranean region and will likely spread in forthcoming decades, posing a complex threat to human health...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28796782/a-new-perspective-on-cutaneous-leishmaniasis-implications-for-global-prevalence-and-burden-of-disease-estimates
#9
Freddie Bailey, Karina Mondragon-Shem, Peter Hotez, José Antonio Ruiz-Postigo, Waleed Al-Salem, Álvaro Acosta-Serrano, David H Molyneux
No abstract text is available yet for this article.
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28795077/sensitive-molecular-diagnostics-for-cutaneous-leishmaniasis
#10
Orli Sagi, Anat Berkowitz, Shlomi Codish, Victor Novack, Aviv Rashti, Fouad Akad, Yonat Shemer-Avni
BACKGROUND: Rapid diagnosis of cutaneous leishmaniasis (CL) and identification of Leishmania species is highly important for the disease management. In Israel, CL is caused mainly by Leishmania major and Leishmania tropica species. METHODS: We established an easy to handle point of care lesion-swabbing, combined with a highly sensitive multiplex real time PCR (multiplex qPCR) for accurate and rapid diagnosis of Leishmania species. RESULTS: Using three probes: one general for: Leishmania species, and two specific for L major, and L tropica, we screened 1783 clinical samples collected during two years...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28794624/nanostructured-delivery-systems-with-improved-leishmanicidal-activity-a-critical-review
#11
REVIEW
Natascia Bruni, Barbara Stella, Leonardo Giraudo, Carlo Della Pepa, Daniela Gastaldi, Franco Dosio
Leishmaniasis is a vector-borne zoonotic disease caused by protozoan parasites of the genus Leishmania, which are responsible for numerous clinical manifestations, such as cutaneous, visceral, and mucocutaneous leishmaniasis, depending on the site of infection for particular species. These complexities threaten 350 million people in 98 countries worldwide. Amastigotes living within macrophage phagolysosomes are the principal target of antileishmanial treatment, but these are not an easy target as drugs must overcome major structural barriers...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28793868/clinical-and-laboratory-profiles-of-patients-with-early-spontaneous-healing-in-cutaneous-localized-leishmaniasis-a-historical-cohort-study
#12
Carla Oliveira-Ribeiro, Maria Inês Fernandes Pimentel, Raquel de Vasconcellos Carvalhaes Oliveira, Aline Fagundes, Maria de Fatima Madeira, Cintia Xavier Mello, Eliame Mouta-Confort, Claudia Maria Valete-Rosalino, Erica de Camargo Ferreira Vasconcellos, Marcelo Rosandiski Lyra, Leonardo Pereira Quintella, Liliane de Fatima Antonio, Armando Schubach, Fatima Conceição-Silva
BACKGROUND: Skin ulcers in American cutaneous leishmaniasis (ACL) may heal spontaneously after months/years. However, few cases may present quick heal even during diagnosis procedure (early spontaneous healing- ESH). The main objective of this study was to compare ESH patients with cases requiring specific treatment [non-ESH (NESH)]. METHODS: A historical cohort study of ACL patients (n = 445) were divided into 2 groups: ESH - spontaneously healed patients (n = 13; 2...
August 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28792090/distinct-activation-mechanisms-trigger-the-trypanocidal-activity-of-dna-damaging-prodrugs
#13
Emma Louise Meredith, Ambika Kumar, Aya Konno, Joanna Szular, Sam Alsford, Karin Seifert, David Horn, Shane R Wilkinson
Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl-1,4-benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutaneous leishmaniasis, identifying several potent structures that exhibited EC50 values of <100 nM. However, these compounds also displayed significant toxicity towards mammalian cells indicating that they are not suitable therapies for systemic infections...
August 9, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28783468/evaluation-of-experimental-infection-with-l-l-amazonensis-in-x-linked-immunodeficient-mice
#14
Patricia Xander, Wagner Francisco Kennerly Marcondes Gonzaga, Mariana Marques Geraldo, Bruno Camolese Vivanco, Ana Flavia Popi, Mario Mariano, Wagner Luiz Batista
B-1 cells are a subtype of B cells with peculiar characteristics. These cells are distinct from B-2 lymphocytes in their morphology, ontogeny, tissue distribution and phenotypic functional features. B-1 cells can participate in the immune response in several ways, for example, by being recruited to inflammatory foci, producing large amounts of IL-10 cytokine, and differentiating into IgM-secreting cells or phagocytes. Nevertheless, the role of B-1 cells in the pathogenesis of experimental leishmaniasis has not been fully elucidated...
August 7, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28783195/murine-cutaneous-leishmaniasis-investigated-by-maldi-mass-spectrometry-imaging
#15
Fernanda Negrão, Daniele F de O Rocha, Caroline F Jaeeger, Francisca J S Rocha, Marcos N Eberlin, Selma Giorgio
Imaging mass spectrometry (IMS) is recognized as a powerful tool to investigate the spatial distribution of untargeted or targeted molecules of a wide variety of samples including tissue sections. Leishmania is a protozoan parasite that causes different clinical manifestations in mammalian hosts. Leishmaniasis is a major public health risk in different continents and represents one of the most important neglected diseases. Cutaneous lesions from mice experimentally infected with Leishmania spp. were investigated by matrix-assisted laser desorption ionization MS using the SCiLS Lab software for statistical analysis...
August 7, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28776770/cutaneous-leishmaniasis-by-leishmania-infantum-behind-granulomatous-lesions-of-unknown-etiology
#16
G Merino-Espinosa, V Corpas-López, V Díaz-Sáez, F Morillas-Márquez, J Tercedor-Sánchez, J M Azaña-Defez, J López-Hidalgo, J Aneiros-Fernández, J Martín-Sánchez
BACKGROUND: Cutaneous leishmaniasis (CL) is underestimated in Spain as in other European countries due to the polymorphism of its clinical manifestations and histopathological features discouraging doctors from suspecting leishmaniasis. Mucosal manifestations (ML) are misdiagnosed due to the fact that they often mimic cancer. OBJECTIVES: Given that leishmaniasis may be masked as different granulomatous diseases in Leishmania infantum endemic areas, the aim of this study is to verify this misdiagnosing and contribute to the improvement of CL/ML diagnosis...
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28771771/studies-on-the-behaviour-and-control-of-phlebotomine-sandflies-using-experimental-houses
#17
O D Kirstein, R Faiman, A Knigin, H Gueta, A Stone, A Warburg
Programmes for the control of phlebotomine sandflies (Diptera: Psychodidae), the vectors of leishmaniases, mainly target adults because larval breeding sites are generally unknown or inaccessible. To determine how blood-questing sandfly females enter homes and to develop means for their control, an experimental house (EH) was constructed in a village endemic for cutaneous leishmaniasis. Initially, carbon dioxide (CO2 )-baited suction traps were installed inside the EH to attract and capture sandflies. For other experiments, the windows of the EH were fitted with CO2 -baited window entrance traps (WETs) that allow each window to be considered as a separate unit...
August 3, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28764662/a-case-report-of-co-infection-of-melioidosis-and-cutaneous-leishmaniasis
#18
Isuru Chamika Indeewara Kahandawaarachchi, Gayani Samadara Premawansa, Wipula Warnasuriya, Malka Dassanayake, Enoka Corea
BACKGROUND: Leishmaniasis and melioidosis are frequently reported from the North Central Province of Sri Lanka. However, only one case of co-infection of the two diseases has been reported to date over the world. This is a case report of a patient who had co-infection with cutaneous leishmaniasis and melioidosis and was successfully treated and recovered from the illness. CASE PRESENTATION: A 61 year old female patient with diabetes mellitus presented with fever for one month's duration and was found to have hepatosplenomegaly and an ulcer over the left arm...
August 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28761481/comparison-of-three-pcr-based-methods-for-simplicity-and-cost-effectiveness-identification-of-cutaneous-leishmaniasis-due-to-leishmania-tropica
#19
Mohammad Ali Mohammadi, Mehdi Bamorovat, Majid Fasihi Harandi, Tayyebeh Karimi, Iraj Sharifi, Mohammad Reza Aflatoonian
BACKGROUND: To compare three molecular methods, PCR-RFLP for internal transcribed spacer, PCR sequencing and high resolution melting analysis shown reliable sensitivity and specificity for detecting Leishmania tropica as a model for cutaneous leishmaniasis (CL) as the perspective overview for scientific and economic approaches. METHODS: This study was carried out between 2015 and 2016 in Leishmaniasis Research Center in Kerman University of Medical Sciences, Kerman, Iran...
April 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28761480/detection-of-potentially-diagnostic-leishmania-antigens-with-western-blot-analysis-of-sera-from-patients-with-cutaneous-and-visceral-leishmaniases
#20
Seyyed Javad Seyyedtabaei, Ali Rostami, Ali Haghighi, Mehdi Mohebali, Bahram Kazemi, Shirzad Fallahi, Adel Spotin
BACKGROUND: Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are important public health problems in Iran. We aimed to evaluate the diagnostic potential of Western blot (WB) compared with indirect immunofluorescence test (IFAT) to serodiagnosis of leishmaniasis. METHODS: This study was performed from 2010-2014 and participants were different parts of Iran. Serum samples were obtained from 43 patients with proven CL, 33 patients with proven VL, 39 patients with other parasitic diseases and 23 healthy individuals...
April 2017: Iranian Journal of Parasitology
keyword
keyword
98721
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"