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cutaneous leishmaniasis

Roghieh Ramezankhani, Nooshin Sajjadi, Roya Nezakati Esmaeilzadeh, Seyed Ali Jozi, Mohammad Reza Shirzadi
Leishmaniasis is a parasitic disease caused by different species of protozoan parasites. Cutaneous leishmaniasis (CL) is still a great public health problem in Iran, especially in Isfahan Province. Distribution and abundance of vectors and reservoirs of this disease is affected by different factors such as climatic, socioeconomic and cultural. This study aimed to identify the hotspot areas for CL in Isfahan and assess the relations between the climatic and topographic factors with CL incidence using spatial analysis...
November 8, 2017: Geospatial Health
Rosiana Estéfane da Silva, Janaína de Pina Carvalho, Dario Brock Ramalho, Maria Camilo Ribeiro De Senna, Hugo Silva Assis Moreira, Ana Rabello, Erika Cota, Gláucia Cota
BACKGROUND Despite its recognised toxicity, antimonial therapy continues to be the first-line drug for cutaneous leishmaniasis (CL) treatment. Intralesional administration of meglumine antimoniate (MA) represents an alternative that could reduce the systemic absorption of the drug and its side effects. OBJECTIVES This study aims to validate the standard operational procedure (SOP) for the intralesional infiltration of MA for CL therapy as the first step before the assessment of efficacy and safety related to the procedure...
February 2018: Memórias do Instituto Oswaldo Cruz
Farhad Handjani, Saeed Reza Yousef, Nasrin Saki, Nasrin Hamidizadeh
Pentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cryotherapy besides its local effects in the treatment of CL. Twenty patients with CL were selected. The disease was confirmed via a direct smear. A venous blood sample was collected to determine IL-10 and IFN-γ levels before starting cryotherapy...
September 2017: Iranian Journal of Medical Sciences
Vanete Thomaz Soccol, Aline Kuhn Sbruzzi Pasquali, Eliane Maria Pozzolo, André de Souza Leandro, Luciana Chiyo, Rafael Antunes Baggio, Mario Sergio Michaliszyn, Carlos Silva, Patrícia Hoerner Cubas, Ricardo Peterlle, Otacilio Lopes de Souza Paz, Ivana Lucia Belmonte, Alceu Bisetto-Junior
A cross-sectional epidemiological study in the extreme-west of the state of Paraná was carried out to access the prevalence, distribution, and risk variables of canine Visceral Leishmaniases (cVL). This study was conducted in three areas, two cities of far west of Parana state: Foz do Iguaçu (FI) and Santa Terezinha de Itaipu (STI), and along two transects between these two municipalities. To sample the entire urban area, the cities (FI and STI) were divided into a grid of squares of 400 m2 (patch). Among the 526 patches, 123 in FI, 40 in the transects and 33 in STI were selected according to the 'worst scenario' criterion...
2017: PloS One
Maritza Fernandez, Javier Murillo, Luz Amalia Ríos-Vásquez, Rogelio Ocampo-Cardona, David L Cedeño, Marjorie A Jones, Iván D Velez, Sara M Robledo
The physicochemical properties of four N-halomethylated and one non-halomethylated ammonium salts, with proven in vitro antileishmanial activity, were determined according to pharmaceutical standard procedures. The effectiveness and toxicity of these compounds were assessed in hamsters infected with Leishmania (Viannia) braziliensis and compared to that showed by meglumine antimoniate. Animals were followed during 90 days after the completion of treatment. Therapeutic response was determined according to the reduction of size of skin lesions...
December 11, 2017: Parasitology Research
S Diadie, B A Diatta, M Ndiaye, N B Seck, S Diallo, S O Niang, M T Dieng
Our aims were to study the epidemiological, clinical, and parasitological aspects of cutaneous leishmaniasis in the dermatology department of the Aristide Le Dantec hospital. This retrospective study reviewed records of cases treated over a 4-year period (from April 2010 through April 2014) at the HALD Dermatology department. The study included all patients with cutaneous leishmaniasis during the study period. The diagnostic criteria were clinical, parasitological, and histological. The study included 38 patients, corresponding to 9...
December 11, 2017: Médecine et Santé Tropicales
Yoshihisa Hashiguchi, Eduardo A Gomez L, Abraham G Cáceres, Lenin N Velez, Nancy V Villegas, Kazue Hashiguchi, Tatsuyuki Mimori, Hiroshi Uezato, Hirotomo Kato
The vector Lutzomyia sand flies and reservoir host mammals of the Leishmania parasites, causing the Andean cutaneous leishmaniasis (Andean-CL, uta) in Peru and Ecuador were thoroughly reviewed, performing a survey of literatures including our unpublished data. The Peruvian L. (V.) peruviana, a principal Leishmania species causing Andean-CL in Peru, possessed three Lutzomyia species, Lu. peruensis, Lu. verrucarum and Lu. ayacuchensis as vectors, while the Ecuadorian L. (L.) mexicana parasite possessed only one species Lu...
December 7, 2017: Acta Tropica
Larissa F Paranaiba, Lucélia J Pinheiro, Diego H Macedo, Armando Menezes-Neto, Ana C Torrecilhas, Wagner L Tafuri, Rodrigo P Soares
One of the Leishmania species known to be non-infective to humans is Leishmania (Mundinia) enriettii whose vertebrate host is the guinea pig Cavia porcellus. It is a good model for cutaneous leishmaniasis, chemotherapeutic and molecular studies. In the last years, an increased interest has emerged concerning the L. (Mundinia) subgenus after the finding of Leishmania (M.) macropodum in Australia and with the description of other new/putative species such as L. (M.) martiniquensis and 'L. (M.) siamensis'. This review focused on histopathology, glycoconjugates and innate immunity...
December 10, 2017: Parasitology
J Herrerias-Moreno, V Expósito-Serrano, E Agut-Busquet, M Corbacho, E Sáez, J Luelmo
No abstract text is available yet for this article.
December 8, 2017: Clinical and Experimental Dermatology
Rúbia S Costa, Lucas P Carvalho, Taís M Campos, Andréa S Magalhães, Sara T Passos, Albert Schriefer, Juliana A Silva, Ednaldo Lago, Camilla S Paixão, Paulo Machado, Phillip Scott, Edgar M Carvalho
Background: Early cutaneous leishmaniasis (ECL) is characterized by a non-ulcerated papular lesion and illness duration less than 30 days. About 4 weeks later the cutaneous leishmaniasis (CL) ulcers appear. Surprisingly, failure following antimony therapy (Sb5) is higher in ECL than CL. We hypothesize that the inflammatory response in ECL patients may increase during Sb5 therapy leading to treatment failure. Methods: A cohort of 44 ECL patients infected by Leishmaniabraziliensis was established to evaluate the response to Sb5, and to compare immunologic responses in ECL patients with CL and healthy subjects (HS)...
December 6, 2017: Journal of Infectious Diseases
Gulcan Gurses, Mehmet Ozaslan, Fadile Yıldız Zeyrek, Ibrahim H Kılıç, Nebiye Yentür Doni, I Didem Karagöz, Nermin Uluca
Cutaneous leishmaniasis (CL) is an important public health problem in Turkey. CL has been most frequently seen in Sanliurfa. There is an expectation of increase in the population of leishmaniasis cases with the influence of Syrian refugees arriving in Turkey. In this study we aimed to diagnosis of CL and identifying of parasite from Leishmania isolates by using ITS 1 PCR RFLP. Samples were collected from 135 CL patients in Sanliurfa. After the specimens were inoculated in medium NNN, the ones which were cultures positive were cultivated in RPMI 1640 followed by PCR-RFLP...
December 7, 2017: Folia Microbiologica
Karina Luiza Dias-Teixeira, Teresa C Calegari-Silva, Jorge M Medina, Áislan C Vivarini, Átila Cavalcanti, Nataly Teteo, Alynne Karen M Santana, Fernando Real, Ciro M Gomes, Renata Meirelles Santos Pereira, Nicolas Fasel, João S Silva, Bertal H Aktas, Ulisses G Lopes
Leishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is activated by Leishmania and this pathway is important for Leishmania amazonensis infection. Knocking down PERK or ATF4 expression or inhibiting PERK kinase activity diminished L. amazonensis infection. Knocking down ATF4 decreased NRF2 expression and its nuclear translocation, reduced HO-1 expression and increased nitric oxide production...
December 6, 2017: Scientific Reports
Lucia Regina Brahim, Cláudia Maria Valete-Rosalino, Liliane de Fátima Antônio, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Luiz Eduardo de Carvalho Paes, Ananda Dutra da Costa, Iracema Forni Vieira, Cristina Maria Giordano Dias, Maria Cristina de Oliveira Duque, Mauro Celio de Almeida Marzochi, Armando de Oliveira Schubach
BACKGROUND: American tegumentary leishmaniasis (ATL) is a non-lethal parasitic disease that presents with cutaneous (CL) and mucosal (ML) clinical forms. ATL treatment aims at healing the lesions and preventing the development of the late mucosal form. Systemic meglumine antimoniate (MA) therapy with 10-20 mg Sb5+/kg/day is the first choice of treatment. However, alternative therapies using 5 mg Sb5+/kg/day or intralesional (IL) MA are the usual regimens at the National Institute of Infectious Diseases (NIID), Rio de Janeiro, Brazil...
December 2017: Memórias do Instituto Oswaldo Cruz
Nafiseh Sadat Nabavi, Fakhrozzaman Pezeshkpoor, Narges Valizadeh, Sanaz Ahmadi Ghezeldasht, Seyyed Abdolrahim Rezaee
The immunopathogenesis of lupoid leishmaniasis is challenging. Although, an appropriate immune response is critical for controlling these parasites, inappropriate inflammatory reactions can also promote increased pathology. The role of immune-modulatory effect of the main transcription factors and cytokines of Tregulatory and Th-17 cells in pathogenesis of leishmaniasis chronicity was investigated in the present study. The gene expression of interleukin-10 (IL-10), transforming growth factor-β (TGF-β1), forkhead box P3 (Foxp3), interleukin-17(IL-17A), and retinoic acid-related orphan receptor gamma t (ROrC) was assessed in PBMCs of eighty blood samples from cutaneous leishmaniasis (CL) patients with usual lesions (n = 31), lupoid lesions (n = 29), and healthy volunteers (n = 20)...
December 4, 2017: Parasite Immunology
Krina B Patel
No abstract text is available yet for this article.
November 2017: Indian Dermatology Online Journal
Natália S Vellozo, Sâmara T Pereira-Marques, Mariela P Cabral-Piccin, Alessandra A Filardy, Flávia L Ribeiro-Gomes, Thaís S Rigoni, George A DosReis, Marcela F Lopes
As key cells, able to host and kill Leishmania parasites, inflammatory monocytes/macrophages are potential vaccine and therapeutic targets to improve immune responses in Leishmaniasis. Macrophage phenotypes range from M1, which express NO-mediated microbial killing, to M2 macrophages that might help infection. Resistance to Leishmaniasis depends on Leishmania species, mouse strain, and both innate and adaptive immunity. C57BL/6 (B6) mice are resistant and control infection, whereas Leishmania parasites thrive in BALB/c mice, which are susceptible to develop cutaneous lesions in the course of infection with Leishmania major, but not upon infection with Leishmania braziliensis...
2017: Frontiers in Immunology
Diego Espinoza-Morales, Aldo Lucchetti Rodríguez, Wilmer Silva-Caso, Luis Suarez-Ognio, María J Pons, Juana Del Valle Mendoza
We present an atypical case of disseminated cutaneous leishmaniasis in the Sihuas district, located in the Andean valleys of Ancash-Peru. A 62-year-old man with no particular medical history presented multiple lesions located on the inferior abdomen, lumbar region and the right anterior thigh. Histological analysis found leishmanial amastigotes in the lesion sample, the Montenegro reaction was positive for Leishmania spp, and the polymerase chain reaction was positive for Leishmania peruviana. In conclusion, the atypical presentation of this disease may be related to the presence of an uncommon parasite strain or host immune deficiencies...
November 2017: Asian Pacific Journal of Tropical Medicine
Hakan Kavur, Hüseyin Arikan, Yusuf Ozbel
Leishmaniasis is a one of the vector-borne diseases and has two clinical forms in Turkey: cutaneous and visceral. The aim of this study was to determine the sand fly fauna in Afyon and Nigde provinces where endemic foci of cutaneous leishmaniasis (CL) in Turkey. In Afyon, 2,259 sand flies were collected in 73 locations in August 2009 and August 2010, using CDC light traps. In total, eight Phlebotomus species were identified; Phlebotomus halepensis (47.41%), Phlebotomus papatasi (31.42%), Phlebotomus neglectus/syriacus (9...
November 30, 2017: Journal of Medical Entomology
Anis Askarizadeh, Mahmoud Reza Jaafari, Ali Khamesipour, Ali Badiee
Leishmaniasis is a parasitic disease that ranges in severity from skin lesions to fatality. Since long-lasting protection is induced upon recovery from cutaneous leishmaniasis, development of an effective vaccine is promising. However, there is no vaccine for use in humans yet. It seems limited efficacy in leishmaniasis vaccines is due to lack of an appropriate adjuvant or delivery system. Hence, the use of particulate adjuvants such as liposomes for effective delivery to the antigen presenting cells (APCs) is a valuable strategy to enhance leishmaniasis vaccine efficacy...
August 2017: Therapeutic Advances in Vaccines
Ines Sifaoui, Atteneri López-Arencibia, Carmen M Martín-Navarro, María Reyes-Batlle, Mondher Mejri, Basilio Valladares, Jacob Lorenzo-Morales, Manef Abderabba, José Enrique Piñero
Leishmaniasis represents a serious threat to the health as one of the most important neglected tropical diseases as designated by the World Health Organization. The disease is endemic in 82 countries, among them Tunisia is an indigenous area for cutaneous Leishmaniasis. In a previous work, two tritepenic acids namely oleanolic and maslinic acids have been isolated from olive leaf extract. In the present paper, the in vitro activity against amastigotes stage of Leishmania (L.) infantum and Leishmania (L.) amazonensis was investigated...
2017: Iranian Journal of Pharmaceutical Research: IJPR
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