keyword
MENU ▼
Read by QxMD icon Read
search

cutaneous leishmaniasis

keyword
https://www.readbyqxmd.com/read/29042262/molecular-epidemiology-and-in-vitro-evidence-suggest-that-leishmania-braziliensis-strain-helps-determine-antimony-response-among-american-tegumenary-leishmaniasis-patients
#1
Silvana C Silva, Luiz Henrique Guimarães, Juliana A Silva, Viviane Magalhães, Lilian Medina, Adriano Queiroz, Paulo Roberto L Machado, Albert Schriefer
Antimony is the first line drug for treating American tegumentary leishmaniasis (ATL) in Brazil. In this country, Leishmania braziliensis causes at least three distinct forms of disease: localized cutaneous (CL), mucosal (ML) and disseminated leishmaniasis (DL). All forms can be found in Corte de Pedra, Northeast Brazil. ML and DL respond poorly to antimony, in contrast to CL. The L. braziliensis population causing ATL in Corte de Pedra is genetically very diverse, with strains of the parasite associating with the clinical form of leishmaniasis...
October 14, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29038500/role-of-mast-cells-in-clearance-of-leishmania-through-extracellular-trap-formation
#2
Nilofer Naqvi, Kavita Ahuja, Angamuthu Selvapandiyan, Ranadhir Dey, Hira Nakhasi, Niti Puri
Mast Cells (MCs) are one of the first immune cells encountered by invading pathogens. Their presence in large numbers in the superficial dermis, where Leishmania is encountered, suggests that they may play a critical role in immune responses to Leishmania. In this study the interactions of Leishmania donovani, the causative agent of visceral Leishmaniasis, and Leishmania tropica, the causative agent of cutaneous Leishmaniasis with MCs were studied. Co-culture of Leishmania with Peritoneal Mast Cells (PMCs) from BALB/c mice and Rat Basophilic Leukaemia (RBL-2H3) MCs led to significant killing of L...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29032112/dermal-pharmacokinetics-of-pyrazinamide-determined-by-microdialysis-sampling-in-rats
#3
Nivea M F Voelkner, Alexander Voelkner, Juliana Costa, Sherwin K B Sy, Juliane Hermes, Johanna Weitzel, Sebastian Morales, Hartmut Derendorf
Studies have demonstrated pyrazinamide's efficacy against stages of the parasite which causes cutaneous leishmaniasis. Although pyrazinamide is widely distributed to most fluids and tissues, the drug distribution that reaches the skin is unknown. The aim of this study was to investigate pyrazinamide pharmacokinetics in rat dermal tissue by dermal microdialysis. Skin pharmacokinetics were assessed by implanting a linear microdialysis probe in the dermis of ten rats. Additionally, blood samples were collected for assessing plasma pharmacokinetics...
October 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29031288/case-report-old-world-mucosal-leishmaniasis-report-of-five-imported-cases-to-the-hospital-for-tropical-diseases-london-united-kingdom
#4
Trupti A Patel, Glenis K Scadding, David E Phillips, Diana N Lockwood
Old World species of Leishmania typically cause visceral and cutaneous leishmaniasis. Mucosal involvement is typically seen with infection by Leishmania species found in South America, usually after the healing of cutaneous leishmaniasis. We present five imported cases of mucosal leishmaniasis caused by Old World Mediterranean Leishmania infantum exclusively affecting the nasal mucosa or vocal cord. In only one case was there a recollection of a preceding cutaneous lesion compatible with cutaneous Leishmaniasis...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29031287/leprosy-associated-with-atypical-cutaneous-leishmaniasis-in-nicaragua-and-honduras
#5
Lucrecia Acosta Soto, Nelson Caballero, Lesny Ruth Fuentes, Pedro Torres Muñoz, Jose Ramón Gómez Echevarría, Montserrat Pérez López, Fernando Jorge Bornay Llinares, John L Stanford, Cynthia A Stanford, Helen D Donoghue
In Central America, few cases of leprosy have been reported, but the disease may be unrecognized. Diagnosis is based on clinical criteria and histology. Preliminary field work in Nicaragua and Honduras found patients, including many children, with skin lesions clinically suggestive of atypical cutaneous leishmaniasis or indeterminate leprosy. Histology could not distinguish these diseases although acid-fast organisms were visible in a few biopsies. Lesions healed after standard antimicrobial therapy for leprosy...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29028841/efficacies-of-prevention-and-control-measures-applied-during-an-outbreak-in-southwest-madrid-spain
#6
Anaiá da Paixão Sevá, Maia Martcheva, Necibe Tuncer, Isabella Fontana, Eugenia Carrillo, Javier Moreno, James Keesling
Leishmaniasis is a vector-borne disease of worldwide distribution, currently present in 98 countries. Since late 2010, an unusual increase of human visceral and cutaneous leishmaniasis cases has been observed in the south-western Madrid region, totaling more than 600 cases until 2015. Some hosts, such as human, domestic dog and cat, rabbit (Oryctolagus cuniculus), and hare (Lepus granatensis), were found infected by the parasite of this disease in the area. Hares were described as the most important reservoir due to their higher prevalence, capacity to infect the vector, and presence of the same strains as in humans...
2017: PloS One
https://www.readbyqxmd.com/read/29026863/assessing-the-ovarian-accessory-glands-to-determine-the-parity-of-phlebotomus-papatasi-vector-of-zoonotic-cutaneous-leishmaniasis-under-laboratory-condition
#7
Mahboubeh Fatemi, Mohammad Reza Yaghoobi-Ershadi, Mehdi Mohebali, Zahra Saeidi, Arshad Veysi, Ali Khamesipour, Amir Ahmad Akhavan
BACKGROUND: Zoonotic cutaneous leishmaniasis (ZCL) is a neglected tropical disease prevailed in many rural areas of 17 out of 31 provinces in Iran. The main vector of the disease is Phlebotomus papatasi and the causative agent is Leishmania major in ZCL foci of Iran. In the current study we investigated the validity of accessory glands secretions as an indicator to recognize parous from nulliparous Ph. papatasi females under laboratory conditions. METHODS: Over 235 laboratory-reared females of Ph...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29026860/evaluation-of-correlation-between-the-in-vitro-susceptibility-of-field-isolates-of-leishmania-major-and-clinical-outcomes-of-meglumine-antimoniate-therapy-in-fars-province-iran
#8
Nafiseh Ghobakhloo, Mohammad Hossein Motazedian, Behrad Pourmohammadi, Zahra Yousefi
BACKGROUND: This study was designed to detect whether there is a correlation between in vitro susceptibility of field isolates of Leishmania major and the clinical outcomes of meglumine antimoniate (Glucantime®) therapy, the mainstay of cutaneous leishmaniasis treatment in Iran. METHODS: Forty-three patients infected with L. major were enrolled in this study from October 2009 to March 2010 and categorized as responsive or unresponsive to Glucantime® treatment after receiving the appropriate therapy...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29026859/molecular-identification-of-leishmania-species-in-a-re-emerged-focus-of-cutaneous-leishmaniasis-in-varamin-district-iran
#9
Mahmoodreza Behravan, Vahideh Moin-Vaziri, Ali Haghighi, Nourina Rahbarian, Niloofar Taghipour, Alireza Abadi, Homa Hajjaran
BACKGROUND: Cutaneous leishmaniasis (CL) is one of the most important neglected tropical diseases and a major public health challenge in Iran caused by Leishmania spp and transmitted by phlebotomine sand flies. The number of CL cases has shown an increasing pattern all over the country, including the district of Varamin, southeast of Tehran, Iran. This study aimed to identify the Leishmania spp isolated from CL patients using molecular methods in Varamin during 2012-2013. METHODS: Exudate materials collected from the swollen edge of the skin lesions of 44 parasitological positive CL patients by disposable lancet...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29026856/synthesis-and-comparison-of-in-vitro-leishmanicidal-activity-of-5-nitroheteroaryl-1-3-4-thiadiazols-containing-cyclic-amine-of-piperidin-4-ol-at-c-2-with-acyclic-amine-analogues-against-iranian-strain-of-leishmania-major-mrho-ir-75-er
#10
Azar Tahghighi, Alireza Foroumadi, Susan Kabudanian-Ardestani, Seyed Mohammad Amin Mahdian
BACKGROUND: Cutaneous Leishmaniasis (CL) is endemic in many tropical and subtropical regions of the world. Due to the prolonged duration of therapy, adverse effect and resistance to current drugs in the treatment of CL, the discovery of novel, efficient, and safe leishmanicidal drugs is required. The aims of the present study was to synthesis of new compounds based on the active compounds of 5-(5-nitrofuran-2-yl)- and 5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazole bearing the linear amino alcohol of 3-aminopropan-1-ol in the C-2 position of thiadiazole ring and evaluation of their activity against the promastigote and amastigote forms of Leishmania major...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29023574/human-cellular-and-humoral-immune-responses-to-phlebotomus-papatasi-salivary-gland-antigens-in-endemic-areas-differing-in-prevalence-of-leishmania-major-infection
#11
Wafa Kammoun-Rebai, Narges Bahi-Jaber, Ikbel Naouar, Amine Toumi, Afif Ben Salah, Hechmi Louzir, Amel Meddeb-Garnaoui
BACKGROUND: Sand fly saliva compounds are able to elicit specific immune responses that have a significant role in Leishmania parasite establishment and disease outcome. Characterizing anti-saliva immune responses in individuals living in well defined leishmaniasis endemic areas would provide valuable insights regarding their effect on parasite transmission and establishment in humans. METHODOLOGY/PRINCIPAL FINDINGS: We explored the cellular and humoral immune responses to Phlebotomus (P...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29020041/how-will-climate-change-pathways-and-mitigation-options-alter-incidence-of-vector-borne-diseases-a-framework-for-leishmaniasis-in-south-and-meso-america
#12
Bethan V Purse, Dario Masante, Nicholas Golding, David Pigott, John C Day, Sergio Ibañez-Bernal, Melanie Kolb, Laurence Jones
The enormous global burden of vector-borne diseases disproportionately affects poor people in tropical, developing countries. Changes in vector-borne disease impacts are often linked to human modification of ecosystems as well as climate change. For tropical ecosystems, the health impacts of future environmental and developmental policy depend on how vector-borne disease risks trade off against other ecosystem services across heterogeneous landscapes. By linking future socio-economic and climate change pathways to dynamic land use models, this study is amongst the first to analyse and project impacts of both land use and climate change on continental-scale patterns in vector-borne diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29017878/andean-cutaneous-leishmaniasis-andean-cl-uta-in-peru-and-ecuador-the-causative-leishmania-parasites-and-clinico-epidemiological-features
#13
REVIEW
Yoshihisa Hashiguchi, Eduardo A L Gomez, Abraham G Cáceres, Lenin N Velez, Nancy V Villegas, Kazue Hashiguchi, Tatsuyuki Mimori, Hiroshi Uezato, Hirotomo Kato
This study provides comprehensive information on the past and current status of the Andean cutaneous leishmaniasis (Andean-CL, uta) in Peru and Ecuador, mainly focusing on the causative Leishmania parasites and clinico-epidemiological features. Available information and data including our unpublished works were analyzed thoroughly. Endemic regions of the Andean-CL (uta) in Peru run from the north Piura/Cajamarca to the south Ayacucho at a wide range of the Pacific watersheds of the Andes through several departments, while in Ecuador those exist at limited and spotted areas in the country's mid-southwestern two provinces, Azuay and Chimborazo...
October 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29016694/efficacy-of-azole-therapy-for-tegumentary-leishmaniasis-a-systematic-review-and-meta-analysis
#14
Endi Lanza Galvão, Ana Rabello, Gláucia Fernandes Cota
BACKGROUND: Several controlled and uncontrolled studies addressing azole antifungal drugs for cutaneous and mucosal leishmaniasis have been published with inconclusive results. We conducted a systematic literature review of studies evaluating the efficacy and toxicity associated with azole therapy for tegumentary leishmaniasis. METHODOLOGY: PRISMA guidelines for systematic reviews and the Cochrane manual were followed, and the review methodology was registered (PROSPERO; CRD42016048668)...
2017: PloS One
https://www.readbyqxmd.com/read/29016328/intralesional-infiltration-with-meglumine-antimoniate-for-the-treatment-of-leishmaniasis-recidiva-cutis-in-ecuador
#15
Manuel Calvopiña, William Cevallos, Yolanda Paredes, Edison Puebla, Jessica Flores, Richard Loor, José Padilla
Meglumine Antimoniate (MA), administered intramuscularly for 21 continuous days is the recommended treatment of leishmaniases in Ecuador. However, because of its toxicity and requirement for intramuscular injections, treatment is frequently abandoned before completion. In addition, therapeutic failure and reactivation are not uncommon. Here we evaluate the efficacy and safety of MA administered intralesionally (IL) in leishmaniasis recidiva cutis (LRC). LRC is a special clinical variant of cutaneous leishmaniasis, characterized by reactivation at the edges of a primary cured lesion, presenting with active papules around the scar...
September 5, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016290/variability-of-cutaneous-leishmaniasis-lesions-is-not-associated-with-genetic-diversity-of-leishmania-tropica-in-khyber-pakhtunkhwa-province-of-pakistan
#16
Nazma Habib Khan, Martin S Llewellyn, Gabriele Schönian, Colin J Sutherland
Leishmania tropica is the causative agent of cutaneous leishmaniasis in Pakistan. Here, intraspecific diversity of L. tropica from northern Pakistan was investigated using multilocus microsatellite typing. Fourteen polymorphic microsatellite markers were typed in 34 recently collected L. tropica isolates from Pakistan along with 158 archival strains of diverse Afro-Eurasian origins. Previously published profiles for 145 strains of L. tropica originating from different regions of Africa, Central Asia, Iran, and Middle East were included for comparison...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28990684/a-new-scenario-in-the-immunohistochemical-diagnosis-of-cutaneous-leishmaniasis
#17
Angel Fernandez-Flores
No abstract text is available yet for this article.
October 9, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28988279/caffeic-acid-combined-with-autoclaved-leishmania-major-boosted-the-protection-of-infected-balb-c-mice-by-enhancing-igg2-production-ifn-%C3%AE-tgf-%C3%AE-and-ino-synthase-arginase1-ratios-and-the-death-of-infected-phagocytes
#18
Radia Belkhelfa-Slimani, Bahia Djerdjouri
BACKGROUND: Immunization with killed Leishmania promastigotes without adjuvant was considered as safe, but gave variable rates of protection. Taking advantage of the immuno-modulatory effect of caffeic acid (CA), a natural polyphenolic antioxidant, we investigated its potentiating effect in autoclaved Leishmania major (ALM)-induced protection of Leishmania major-infected BALB/c. METHODS: First, BALB/c mice were sensitized for 6 weeks either with CA, or ALM alone or combined with caffeic acid (ALM-CA) or Freund's adjuvant (ALM-FA), and subsequently infected with L...
October 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28984989/treating-murine-kala-azar-with-a-mayan-plant-induces-immunochemical-changes
#19
C M Lezama-Dávila, A P Isaac-Márquez
AIMS: Pentalinon andrieuxii-Muell-Arg is a Mexican-Central American plant anciently used by local people to treat cutaneous leishmaniasis. We evaluated a hexane extract of the root we called PAE for its chemical content and for its immunochemical and in vitro activity against Leishmania donovani and healing of experimental Kala Azar. METHODS AND RESULTS: Chemical analysis using gas chromatography coupled to mass spectrometry (GC-MS) identified hexadecanoic acid, hexadecanoic acid ethyl ester, 9, 12-octadecadienoic acid ethyl ester, octadecanoic acid ethyl ester, 9-octadecenoic acid ethyl ester and diethyl phthalate as the main compounds present in PAE...
October 6, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28982577/evaluating-the-anti-leishmania-activity-of-lucilia-sericata-and-sarconesiopsis-magellanica-blowfly-larval-excretions-secretions-in-an-in-vitro-model
#20
Mayra Juliana Laverde-Paz, María Clara Echeverry, Manuel Alfonso Patarroyo, Felio Jesús Bello
Leishmaniasis is a vector-borne disease caused by infection by parasites from the genus Leishmania. Clinical manifestations can be visceral or cutaneous, the latter mainly being chronic ulcers. This work was aimed at evaluating Calliphoridae Lucilia sericata- and Sarconesiopsis magellanica-derived larval excretions and secretions' (ES) in vitro anti-leishmanial activity against Leishmania panamensis. Different larval-ES concentrations from both blowfly species were tested against either L. panamensis promastigotes or intracellular amastigotes using U937-macrophages as host cells...
October 2, 2017: Acta Tropica
keyword
keyword
98721
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"