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C Ginja, L T Gama, A Martínez, N Sevane, I Martin-Burriel, M R Lanari, M A Revidatti, J A Aranguren-Méndez, D O Bedotti, M N Ribeiro, P Sponenberg, E L Aguirre, L A Alvarez-Franco, M P C Menezes, E Chacón, A Galarza, N Gómez-Urviola, O R Martínez-López, E C Pimenta-Filho, L L da Rocha, A Stemmer, V Landi, J V Delgado-Bermejo
Biodiversity studies are more efficient when large numbers of breeds belonging to several countries are involved, as they allow for an in-depth analysis of the within- and between-breed components of genetic diversity. A set of 21 microsatellites was used to investigate the genetic composition of 24 Creole goat breeds (910 animals) from 10 countries to estimate levels of genetic variability, infer population structure and understand genetic relationships among populations across the American continent. Three commercial transboundary breeds were included in the analyses to investigate admixture with Creole goats...
January 17, 2017: Animal Genetics
M G Ferreira-García, A R Hernandez-Martinez, R Esparza, G A Molina, F Rodriguez-Melgarejo, S Jiménez, M Estevez
Currently, nanomaterials had been used for several applications; one of them is as bio-markers. These nanomaterials contain fluorescent compounds as effective indicators for imaging and other applications in Biotechnology. In previous studies, we proposed a functionalized nanomaterial-based biomarker from silica and Eysenhardtia Polystachia, a medicinal tree known in Mexico as "palo azul" (Kidneywood). Our previous results showed the feasibility of the nanomaterial obtained as bio-marker. In this article, our purpose is to evaluate the effects of extraction solvents on fluorescence of that biomarker...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
N C Aquino, E F Queiroz, L Marcourt, Fvcs Azul, Jac Sousa, Hhs Amaral, Lkam Leal, J L Wolfender, E R Silveira
No abstract text is available yet for this article.
December 2016: Planta Medica
Inmaculada Palanca-Maresca, Belén Ruiz-Antorán, Gustavo Adolfo Centeno-Soto, Maria Azul Forti-Buratti, Ana Siles, Ana Usano, Cristina Avendaño-Solá
PURPOSE: This study aimed to describe the prevalence of corrected QT (QTc) interval disorders and the possible predisposing factors in children and adolescents treated with antipsychotic (AP) medications in a real-world population with a long-term follow-up. METHODS: Data were obtained from the SafEty of NeurolepTics in Infancy and Adolescence (SENTIA) registry ( The SENTIA includes patients younger than 18 years who are currently taking or initiating treatment with AP medications and have agreed to participate in the registry...
February 2017: Journal of Clinical Psychopharmacology
Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes, Marcus Felipe Bezerra da Costa, Gdayllon Cavalcante Meneses, Mauren Cristina Villalta Arrieta, Adriano José Maia Chaves Filho, Glayciane Bezerra de Morais, Alexandre Braga Libório, Renata Sousa Alves, Janaína Serra Azul Monteiro Evangelista, Alice Maria Costa Martins
BACKGROUND: Ischemia/reperfusion (I/R) in kidney is commonly related to acute kidney injury (AKI), essentially through oxidative stress. (-)-α-Bisabolol is a sesquiterpene isolated from the essential oil of a variety of plants, including chamomile, which has important antioxidant activity. STUDY DESIGN: This study intends to evaluate the nephroprotective activity of (-)-α-bisabolol (Bis) in both in vivo and in vitro models of kidney I/R. METHODS: Male Wistar rats were submitted to right nephrectomy, followed by ischemia by clamping of the renal artery in the left kidney for 60min...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Roberta Jeane Bezerra Jorge, Antônio Rafael Coelho Jorge, Ramon Róseo Paula Pessoa Bezerra de Menezes, Clarissa Perdigão Mello, Danya Bandeira Lima, João Alison de Moraes Silveira, Natacha Teresa Queiroz Alves, Aline Diogo Marinho, Rafael Matos Ximenes, Carlos Corrêa-Netto, Larissa Gonçalves Machado, Russolina Benedeta Zingali, Alice Maria Costa Martins, Helena Serra Azul Monteiro
Components from animal venoms may vary according to the snake's age, gender and region of origin. Recently, we performed a proteomic analysis of Bothrops jararaca venom from southern (BjSv) and southeastern (BjSEv) Brazil, showing differences in the venom composition, as well as its biological activity. To continue the study, we report in this short communication the different effects induced by the BjSEv and BjSv on isolated kidney and MDCK renal cells. BjSEv decreased perfusion pressure (PP) and renal vascular resistance (RVR) and increased urinary flow (UF) and glomerular filtration rate (GFR), while BjSv did not alter PP and RVR and reduced UF and GFR...
January 2017: Toxicon: Official Journal of the International Society on Toxinology
Juan Ramón de la Fuente
Cuando la Secretaría de Salud todavía tenía el logotipo azul que decía SSA, corrían tiempos difíciles porque no había dinero y la idea de crear nuevas instituciones era recibida con reservas, no sólo por el Presidente Zedillo, siempre generoso y atento a las necesidades de salud de la población, sino también, como ya es costumbre, por el secretario de Hacienda, responsable de cuidar el erario público. Y es que la idea de hacer crecer el gasto corriente del gobierno se percibía, no sin razón, como un acto que podía infligir el riesgo de fomentar estructuras administrativas ineficaces y obesas...
November 2016: Gaceta Médica de México
Silvia Echeverría-Sáenz, Freylan Mena, María Arias-Andrés, Seiling Vargas, Clemens Ruepert, Paul J Van den Brink, Luisa E Castillo, Jonas S Gunnarsson
The River Madre de Dios (RMD) and its lagoon is a biodiversity rich watershed formed by a system of streams, rivers, channels, and a coastal lagoon communicating with the Caribbean Sea. This basin sustains a large area of agricultural activity (mostly banana, rice, and pineapple) with intensive use of pesticides, continually detected in water samples. We investigated in situ the toxicological effects caused by pesticide runoff from agriculture and the relation of pesticide concentrations with different biological organization levels: early responses in fish biomarkers (sub-organismal), acute toxicity to Daphnia magna (organismal), and aquatic macroinvertebrate community structure...
October 18, 2016: Environmental Science and Pollution Research International
Xiaojuan Huang, Jung-Ho Shin, Azul Pinochet-Barros, Tina T Su, John D Helmann
The Bacillus subtilis MntR metalloregulatory protein senses manganese, an essential element required for central metabolism, oxidative stress resistance and replication. An mntR null mutant is highly sensitive to Mn(II) intoxication, which is attributed in part to the constitutive expression of two importers: the proton-dependent NRAMP family transporter MntH and the ABC transporter MntABCD. Here, we show that an mntR null mutant is still sensitive to Mn(II) intoxication even if both of the import systems are absent...
January 2017: Molecular Microbiology
Azul Zorzoli, James P Grayczyk, Francis Alonzo
To thrive in diverse environments, bacteria must shift their metabolic output in response to nutrient bioavailability. In many bacterial species, such changes in metabolic flux depend upon lipoic acid, a cofactor required for the activity of enzyme complexes involved in glycolysis, the citric acid cycle, glycine catabolism, and branched chain fatty acid biosynthesis. The requirement of lipoic acid for metabolic enzyme activity necessitates that bacteria synthesize the cofactor and/or scavenge it from environmental sources...
October 2016: PLoS Pathogens
Mariano Palermo, Edgardo Serra
Background: Gastric bypass is a restrictive and malabsorptive surgery. The restrictive part consists in the creation of a small gastric pouch. The gastrointestinal bypass serves as the malabsorptive element. Aim: To describe a simplified gastric bypass approach for morbid obese patients, showing our results, and also remarking the importance of this technique for reducing the learning curve. Method: The patient is positioned in a split legs position and carefully strapped to the operating room table, with the surgeon between the patient's legs...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Daniela Soto, María Gomez-Serrano, Azul Pieralisi, Juan C Calvo, Belén Peral, Liliana N Guerra
OBJECTIVES: Reports investigating the effects of antioxidants on obesity have provided contradictory results. We have previously demonstrated that treatment with the antioxidant N-acetylcysteine (NAC) inhibits cellular triglyceride (Tg) accumulation as well as total cellular monoamine oxidase A (MAOA) expression in 3T3-L1 mature adipocytes (Calzadilla et al., Redox Rep. 2013;210-218). Here we analyzed the role of NAC on adipogenic differentiation pathway. METHODS: Assays were conducted using 3T3-L1 preadipocytes (undifferentiated cells: CC), which are capable of differentiating into mature adipocytes (differentiated cells: DC)...
September 27, 2016: Redox Report: Communications in Free Radical Research
Humberto Ferreira de Oliveira Quites, Mery Natali Silva Abreu, Leonardo Ferreira Matoso, Andrea Gazzinelli
Observational study that examined the quality of the preventive actions for schistosomiasis control in the Brazilian Family Health Strategy (FHS) in an endemic area. Structured questionnaires were used to interview 97 health professionals of the FHS and the Secretary of Health of 25 municipalities belonging to the State Health Department of Pedra Azul, Minas Gerais, Brazil. Models of latent variables were used to define a score to evaluate the quality of the process. The results showed that 57.8% of the FHS teams' actions were unsatisfactory or critical...
April 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Guillermo Hernández-Cortés, Juan Octavio Valle-Rodríguez, Enrique J Herrera-López, Dulce María Díaz-Montaño, Yolanda González-García, Héctor B Escalona-Buendía, Jesús Córdova
Agave (Agave tequilana Weber var. azul) fermentations are traditionally carried out employing batch systems in the process of tequila manufacturing; nevertheless, continuous cultures could be an attractive technological alternative to increase productivity and efficiency of sugar to ethanol conversion. However, agave juice (used as a culture medium) has nutritional deficiencies that limit the implementation of yeast continuous fermentations, resulting in high residual sugars and low fermentative rates. In this work, fermentations of agave juice using Saccharomyces cerevisiae were put into operation to prove the necessity of supplementing yeast extract, in order to alleviate nutritional deficiencies of agave juice...
December 2016: AMB Express
David Azul, Ulrika Nygren, Maria Södersten, Christiane Neuschaefer-Rube
OBJECTIVES: This study aims to evaluate the currently available discursive and empirical data relating to those aspects of transmasculine people's vocal situations that are not primarily gender-related, to identify restrictions to voice function that have been observed in this population, and to make suggestions for future voice research and clinical practice. METHODS: We conducted a comprehensive review of the voice literature. Publications were identified by searching six electronic databases and bibliographies of relevant articles...
June 16, 2016: Journal of Voice: Official Journal of the Voice Foundation
Hiromi Sato, Asami Funaki, Yuki Kimura, Mai Sumitomo, Hiroya Yoshida, Hideki Fukata, Koichi Ueno
In this study, we examined the cell differentiation effect of an ethanol extract of Cyclolepis genistoides D. Don, a herbaceous perennial belonging to the family Asteraceae (vernacular name: palo azul). Palo azul has numerous physiological effects that contribute to the prevention of metabolic syndromes, although the mechanism remains unclear. We previously suggested that palo azul has antidiabetic activity via an adipose differentiation effect. Here, we focused on whether palo azul promoted the differentiation of myoblasts...
July 2016: Nutrition Research
Luiz André C Brizeno, Ana Maria S Assreuy, Ana Paula N N Alves, Fabrício B Sousa, Paulo Goberlânio de B Silva, Suzana Cantanhede O Machado de Sousa, Nelise A S Lascane, Janaína Serra-Azul M Evangelista, Mário Rogério L Mota
No abstract text is available yet for this article.
June 15, 2016: Life Sciences
Allan P M Santos, Daniela M Takiya, Jorge L Nessimian
Metrichia is assigned to the Ochrotrichiinae, a group of almost exclusively Neotropical microcaddisflies. Metrichia comprises over 100 described species and, despite its diversity, only one species has been described from Brazil so far. In this paper, we provide descriptions for 20 new species from 8 Brazilian states: M. acuminata sp. nov., M. azul sp. nov., M. bonita sp. nov., M. bracui sp. nov., M. caraca sp. nov., M. circuliforme sp. nov., M. curta sp. nov., M. farofa sp. nov., M. forceps sp. nov., M. formosinha sp...
2016: PeerJ
Fabíola Carine Monteiro de Sousa, Antônio Rafael Coelho Jorge, Ramon Róseo Paula Pessoa Bezerra de Menezes, Alba Fabíola Costa Torres, Clarissa Perdigão Mello, Danya Bandeira Lima, Diva Maria Borges Nojosa, Alexandre Havt, Renata Sousa Alves, Alice Maria Costa Martins, Helena Serra Azul Monteiro
Bothrops erythromelas is responsible for a large number of snakebite incidents in Northeastern Brazil. Previously, we showed the effects of whole B. erythromelas venom in an isolated kidney model. To continue the study with B. erythromelas venom, the present work aims to study the effects of this venom on MDCK tubular epithelial cells and assess gene expression involved in kidney injury, aiming at elucidating the mechanisms responsible for renal toxicity. Cytotoxicity in MDCK cells showed an IC50 of 93 μg/mL and predominant apoptotic involvement demonstrated by flow cytometry assays and expression of caspase-3 and caspase-8...
August 2016: Toxicon: Official Journal of the International Society on Toxinology
Ticiana Monteiro Abreu, Natássia Albuquerque Ribeiro, Hellíada Vasconcelos Chaves, Roberta Jeane Bezerra Jorge, Mirna Marques Bezerra, Helena Serra Azul Monteiro, Ilka Maria Vasconcelos, Érika Freitas Mota, Norma Maria Barros Benevides
Lectins are proteins that bind to specific mono- or oligosaccharides. This study aimed to evaluate the antinociceptive and anti-inflammatory effects of the lectin from the red marine alga Solieria filiformis. The animals (n = 6) were pretreated with S. filiformis lectin 30 min before they were given the nociceptive or inflammatory stimulus. The antinociceptive activity was evaluated in Swiss mice using the abdominal writhing, formalin, and hot plate tests. The anti-inflammatory properties were evaluated in Wistar rats using carrageenan-induced peritonitis and paw edema induced by different phlogistic agents...
May 2016: Planta Medica
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