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https://www.readbyqxmd.com/read/28837825/renal-effects-of-bunodosoma-caissarum-crude-extract-prostaglandin-and-endothelin-involvement
#1
René Duarte Martins, Roberta Jeane Bezerra Jorge, Renata de Sousa Alves, Antônio Gomes da Silva Neto, Paulo Sergio F Barbosa, Alice Maria Costa Martins, Marcos H Toyama, Helena Serra Azul Monteiro
Sea anemones contain a variety of interesting biologically active compounds, including some potent toxins. PLA2 from Bunodosoma caissarum, a sea anemone endemic in the Brazilian southern coast, has shown renal alterations on isolated kidney. The aim of this study was to evaluate the renal and vascular effects of B. caissarum crude extract (BcE) on isolated perfused kidney and arteriolar mesenteric bed, as well the involvement of prostaglandins and endothelin. BcE did not show any effect on arteriolar mesenteric bed, but increased perfusion pressure, renal vascular resistance, urinary flow, glomerular filtration rate and decreased the percentage of sodium tubular transport on isolated perfused kidney...
August 23, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28769671/a-new-species-of-semiarboreal-toad-of-the-rhinella-festae-group-anura-bufonidae-from-the-cordillera-azul-national-park-peru
#2
Juan C Cusi, Jiří Moravec, Edgar Lehr, Václav Gvoždík
A new semiarboreal species of the Rhinella festae group is described from montane forests of the Cordillera Azul National Park between 1245 and 1280 m a.s.l. in the Cordillera Oriental, San Martín region, northern Peru. The new species is morphologically and genetically compared with members of the Rhinella acrolopha group (former genus Rhamphophryne) and members of the R. festae group. The new species is characterized by its large size (female SVL 47.1-58.3 mm, n = 4), eight presacral vertebrae, fusion of the sacrum and coccyx, long protuberant snout, snout directed slightly anteroventral in lateral view, cranial crests moderately developed, absence of occipital crest, presence of tympanic membrane, dorsolateral rows of small conical tubercles extending from parotoid gland to groin, hands and feet with long digits, fingers basally webbed and toes moderately webbed...
2017: ZooKeys
https://www.readbyqxmd.com/read/28760509/pulmonary-mechanic-and-lung-histology-induced-by-crotalus-durissus-cascavella-snake-venom
#3
Joselito de Oliveira Neto, João Alison de Moraes Silveira, Daniel Silveira Serra, Daniel de Araújo Viana, Diva Maria Borges-Nojosa, Célia Maria Souza Sampaio, Helena Serra Azul Monteiro, Francisco Sales Ávila Cavalcante, Janaina Serra Azul Monteiro Evangelista
This study have analyzed the pulmonary function in an experimental model of acute lung injury, induced by the Crotalus durissus cascavella venom (C. d. cascavella) (3.0 μg/kg - i.p), in pulmonary mechanic and histology at 1 h, 3 h, 6 h, 12 h and 24 h after inoculation. The C. d. cascavella venom led to an increase in Newtonian Resistance (RN), Tissue Resistance (G) and Tissue Elastance (H) in all groups when compared to the control, particularly at 12 h and 24 h. The Histeresivity (η) increased 6 h, 12 h and 24 h after inoculation...
July 28, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28693020/propiedades-biomec%C3%A3-nicas-de-la-membrana-limitante-interna-tras-recibir-tratamiento-intrav%C3%A3-treo-con-ocriplasmina
#4
Franziska Vielmuth, Ricarda G Schumann, Volker Spindler, Armin Wolf, Renate Scheler, Wolfgang J Mayer, Paul B Henrich, Christos Haritoglou
Objetivo: Evaluar la rigidez de la membrana limitante interna (MLI) humana y evaluar los posibles cambios de las propiedades mecánicas tras administrar una inyección intravítrea de ocriplasmina para tratar la tracción vitreomacular. Métodos: Este estudio se compone de una serie de casos intervencionales y comparativos de 12 muestras de MLI extraídas mediante cirugía y obtenidas de forma consecutiva de 9 ojos de 9 pacientes después de someterse sin éxito a vitreólisis farmacológica con ocriplasmina...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28682268/assessment-of-homomorphic-analysis-for-human-activity-recognition-from-acceleration-signals
#5
Sebastian Rodrigo Vanrell, Diego Humberto Milone, Hugo Leonardo Rufiner
Unobtrusive activity monitoring can provide valuable information for medical and sports applications. In recent years, human activity recognition has moved to wearable sensors to deal with unconstrained scenarios. Accelerometers are the preferred sensors due to their simplicity and availability. Previous studies have examined several \azul{classic} techniques for extracting features from acceleration signals, including time-domain, time-frequency, frequency-domain, and other heuristic features. Spectral and temporal features are the preferred ones and they are generally computed from acceleration components, leaving the acceleration magnitude potential unexplored...
July 3, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28481025/sorption-and-desorption-of-glyphosate-in-mollisols-and-ultisols-soils-of-argentina
#6
Ana Maria Gómez Ortiz, Elena Okada, Francisco Bedmar, José Luis Costa
In Argentina, glyphosate use has increased exponentially in recent years as a result of the widespread adoption of no-till management combined with genetically modified glyphosate-resistant crops. This massive use of glyphosate has created concern about its potential environmental impact. Sorption-desorption of glyphosate was studied in 3 Argentinean soils with contrasting characteristics. Glyphosate sorption isotherms were modeled using the Freundlich equation to estimate the sorption coefficient (Kf ). Glyphosate sorption was high, and the Kf varied from 115...
May 8, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28412287/changes-in-rat-respiratory-system-produced-by-exposure-to-exhaust-gases-of-combustion-of-glycerol
#7
Daniel Silveira Serra, Janaína Serra Azul Monteiro Evangelista, Walter Araujo Zin, José Henrique Leal-Cardoso, Francisco Sales Ávila Cavalcante
The combustion of residual glycerol to generate heat in industrial processes has been suggested as a cost-effective solution for disposal of this environmental liability. Thus, we investigated the effects of exposure to the exhaust gases of glycerol combustion in the rat respiratory system. We used 2 rats groups, one exposed to the exhaust gases from glycerol combustion (Glycerol), and the other exposed to ambient air (Control). Exposure occurred 5h a day, 5days a week for 13 weeks. We observed statistically changes in all parameters of respiratory system mechanics in vivo...
April 12, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28384059/potential-sympatric-vectors-and-mammalian-hosts-of-venezuelan-equine-encephalitis-virus-in-southern-mexico
#8
Jesús Sotomayor-Bonilla, Carlos Antonio Abella-Medrano, Andrea Chaves, Paulina Álvarez-Mendizábal, Óscar Rico-Chávez, Sergio Ibáñez-Bernal, Melinda K Rostal, Rafael Ojeda-Flores, Arturo Barbachano-Guerrero, Gustavo Gutiérrez-Espeleta, A Alonso Aguirre, Peter Daszak, Gerardo Suzán
Arboviruses are important zoonotic agents with complex transmission cycles and are not well understood because they may involve many vectors and hosts. We studied sympatric wild mammals and hematophagous mosquitoes having the potential to act as hosts and vectors in two areas of southern Mexico. Mosquitoes, bats, and rodents were captured in Calakmul (Campeche) and Montes Azules (Chiapas), between November 2010 and August 2011. Spleen samples from 146 bats and 14 rodents were tested for molecular evidence of Venezuelan equine encephalitis virus (VEEV), eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV), and West Nile virus (WNV) using PCR protocols...
July 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28348051/iron-efflux-by-pmta-is-critical-for-oxidative-stress-resistance-and-contributes-significantly-to-group-a-streptococcus-virulence
#9
Arica R VanderWal, Nishanth Makthal, Azul Pinochet-Barros, John D Helmann, Randall J Olsen, Muthiah Kumaraswami
Group A Streptococcus (GAS) is a human-only pathogen that causes a spectrum of disease conditions. Given its survival in inflamed lesions, the ability to sense and overcome oxidative stress is critical for GAS pathogenesis. PerR senses oxidative stress and coordinates the regulation of genes involved in GAS antioxidant defenses. In this study, we investigated the role of PerR-controlled metal transporter A (PmtA) in GAS pathogenesis. Previously, PmtA was implicated in GAS antioxidant defenses and suggested to protect against zinc toxicity...
June 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28094449/genetic-diversity-and-patterns-of-population-structure-in-creole-goats-from-the-americas
#10
C Ginja, L T Gama, A Martínez, N Sevane, I Martin-Burriel, M R Lanari, M A Revidatti, J A Aranguren-Méndez, D O Bedotti, M N Ribeiro, P Sponenberg, E L Aguirre, L A Alvarez-Franco, M P C Menezes, E Chacón, A Galarza, N Gómez-Urviola, O R Martínez-López, E C Pimenta-Filho, L L da Rocha, A Stemmer, V Landi, J V Delgado-Bermejo
Biodiversity studies are more efficient when large numbers of breeds belonging to several countries are involved, as they allow for an in-depth analysis of the within- and between-breed components of genetic diversity. A set of 21 microsatellites was used to investigate the genetic composition of 24 Creole goat breeds (910 animals) from 10 countries to estimate levels of genetic variability, infer population structure and understand genetic relationships among populations across the American continent. Three commercial transboundary breeds were included in the analyses to investigate admixture with Creole goats...
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28024605/effects-of-extraction-solvents-on-photoluminescent-properties-of-eysenhardtia-polystachia-and-their-potential-usage-as-biomarker
#11
M G Ferreira-García, A R Hernandez-Martinez, R Esparza, G A Molina, F Rodriguez-Melgarejo, S Jiménez, M Estevez
Currently, nanomaterials had been used for several applications; one of them is as bio-markers. These nanomaterials contain fluorescent compounds as effective indicators for imaging and other applications in Biotechnology. In previous studies, we proposed a functionalized nanomaterial-based biomarker from silica and Eysenhardtia Polystachia, a medicinal tree known in Mexico as "palo azul" (Kidneywood). Our previous results showed the feasibility of the nanomaterial obtained as bio-marker. In this article, our purpose is to evaluate the effects of extraction solvents on fluorescence of that biomarker...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27975582/phytochemical-analysis-of-the-decoction-from-leaves-of-cultivated-specimens-of-myracrodruon-urundeuva-aroeira-do-sert%C3%A3-o
#12
N C Aquino, E F Queiroz, L Marcourt, Fvcs Azul, Jac Sousa, Hhs Amaral, Lkam Leal, J L Wolfender, E R Silveira
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27930499/prevalence-and-risk-factors-of-prolonged-corrected-qt-interval-among-children-and-adolescents-treated-with-antipsychotic-medications-a-long-term-follow-up-in-a-real-world-population
#13
Inmaculada Palanca-Maresca, Belén Ruiz-Antorán, Gustavo Adolfo Centeno-Soto, Maria Azul Forti-Buratti, Ana Siles, Ana Usano, Cristina Avendaño-Solá
PURPOSE: This study aimed to describe the prevalence of corrected QT (QTc) interval disorders and the possible predisposing factors in children and adolescents treated with antipsychotic (AP) medications in a real-world population with a long-term follow-up. METHODS: Data were obtained from the SafEty of NeurolepTics in Infancy and Adolescence (SENTIA) registry (https://sentia.es). The SENTIA includes patients younger than 18 years who are currently taking or initiating treatment with AP medications and have agreed to participate in the registry...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27912887/nephroprotective-effects-of-%C3%AE-bisabolol-against-ischemic-reperfusion-acute-kidney-injury
#14
Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes, Marcus Felipe Bezerra da Costa, Gdayllon Cavalcante Meneses, Mauren Cristina Villalta Arrieta, Adriano José Maia Chaves Filho, Glayciane Bezerra de Morais, Alexandre Braga Libório, Renata Sousa Alves, Janaína Serra Azul Monteiro Evangelista, Alice Maria Costa Martins
BACKGROUND: Ischemia/reperfusion (I/R) in kidney is commonly related to acute kidney injury (AKI), essentially through oxidative stress. (-)-α-Bisabolol is a sesquiterpene isolated from the essential oil of a variety of plants, including chamomile, which has important antioxidant activity. STUDY DESIGN: This study intends to evaluate the nephroprotective activity of (-)-α-bisabolol (Bis) in both in vivo and in vitro models of kidney I/R. METHODS: Male Wistar rats were submitted to right nephrectomy, followed by ischemia by clamping of the renal artery in the left kidney for 60min...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27867094/differences-between-renal-effects-of-venom-from-two-bothrops-jararaca-populations-from-southeastern-and-southern-brazil
#15
COMPARATIVE STUDY
Roberta Jeane Bezerra Jorge, Antônio Rafael Coelho Jorge, Ramon Róseo Paula Pessoa Bezerra de Menezes, Clarissa Perdigão Mello, Danya Bandeira Lima, João Alison de Moraes Silveira, Natacha Teresa Queiroz Alves, Aline Diogo Marinho, Rafael Matos Ximenes, Carlos Corrêa-Netto, Larissa Gonçalves Machado, Russolina Benedeta Zingali, Alice Maria Costa Martins, Helena Serra Azul Monteiro
Components from animal venoms may vary according to the snake's age, gender and region of origin. Recently, we performed a proteomic analysis of Bothrops jararaca venom from southern (BjSv) and southeastern (BjSEv) Brazil, showing differences in the venom composition, as well as its biological activity. To continue the study, we report in this short communication the different effects induced by the BjSEv and BjSv on isolated kidney and MDCK renal cells. BjSEv decreased perfusion pressure (PP) and renal vascular resistance (RVR) and increased urinary flow (UF) and glomerular filtration rate (GFR), while BjSv did not alter PP and RVR and reduced UF and GFR...
January 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27861469/-the-national-medical-arbitration-commission-20-years
#16
Juan Ramón de la Fuente
Cuando la Secretaría de Salud todavía tenía el logotipo azul que decía SSA, corrían tiempos difíciles porque no había dinero y la idea de crear nuevas instituciones era recibida con reservas, no sólo por el Presidente Zedillo, siempre generoso y atento a las necesidades de salud de la población, sino también, como ya es costumbre, por el secretario de Hacienda, responsable de cuidar el erario público. Y es que la idea de hacer crecer el gasto corriente del gobierno se percibía, no sin razón, como un acto que podía infligir el riesgo de fomentar estructuras administrativas ineficaces y obesas...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27757743/in-situ-toxicity-and-ecological-risk-assessment-of-agro-pesticide-runoff-in-the-madre-de-dios-river-in-costa-rica
#17
Silvia Echeverría-Sáenz, Freylan Mena, María Arias-Andrés, Seiling Vargas, Clemens Ruepert, Paul J Van den Brink, Luisa E Castillo, Jonas S Gunnarsson
The River Madre de Dios (RMD) and its lagoon is a biodiversity rich watershed formed by a system of streams, rivers, channels, and a coastal lagoon communicating with the Caribbean Sea. This basin sustains a large area of agricultural activity (mostly banana, rice, and pineapple) with intensive use of pesticides, continually detected in water samples. We investigated in situ the toxicological effects caused by pesticide runoff from agriculture and the relation of pesticide concentrations with different biological organization levels: early responses in fish biomarkers (sub-organismal), acute toxicity to Daphnia magna (organismal), and aquatic macroinvertebrate community structure...
October 18, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27748968/bacillus-subtilis-mntr-coordinates-the-transcriptional-regulation-of-manganese-uptake-and-efflux-systems
#18
Xiaojuan Huang, Jung-Ho Shin, Azul Pinochet-Barros, Tina T Su, John D Helmann
The Bacillus subtilis MntR metalloregulatory protein senses manganese, an essential element required for central metabolism, oxidative stress resistance and replication. An mntR null mutant is highly sensitive to Mn(II) intoxication, which is attributed in part to the constitutive expression of two importers: the proton-dependent NRAMP family transporter MntH and the ABC transporter MntABCD. Here, we show that an mntR null mutant is still sensitive to Mn(II) intoxication even if both of the import systems are absent...
January 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/27701474/staphylococcus-aureus-tissue-infection-during-sepsis-is-supported-by-differential-use-of-bacterial-or-host-derived-lipoic-acid
#19
Azul Zorzoli, James P Grayczyk, Francis Alonzo
To thrive in diverse environments, bacteria must shift their metabolic output in response to nutrient bioavailability. In many bacterial species, such changes in metabolic flux depend upon lipoic acid, a cofactor required for the activity of enzyme complexes involved in glycolysis, the citric acid cycle, glycine catabolism, and branched chain fatty acid biosynthesis. The requirement of lipoic acid for metabolic enzyme activity necessitates that bacteria synthesize the cofactor and/or scavenge it from environmental sources...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27683785/simplified-laparoscopic-gastric-bypass-with-gastrojejunal-linear-mechanical-anastomosis-technical-aspects
#20
Mariano Palermo, Edgardo Serra
Background: Gastric bypass is a restrictive and malabsorptive surgery. The restrictive part consists in the creation of a small gastric pouch. The gastrointestinal bypass serves as the malabsorptive element. Aim: To describe a simplified gastric bypass approach for morbid obese patients, showing our results, and also remarking the importance of this technique for reducing the learning curve. Method: The patient is positioned in a split legs position and carefully strapped to the operating room table, with the surgeon between the patient's legs...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
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