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https://www.readbyqxmd.com/read/28078564/mri-measurements-of-brainstem-structures-in-patients-with-vascular-parkinsonism-progressive-supranuclear-palsy-and-parkinson-s-disease
#1
Byeong C Kim, Seong-Min Choi, Kang-Ho Choi, Tai-Seung Nam, Joon-Tae Kim, Seung-Han Lee, Man-Seok Park, Woong Yoon
Magnetic resonance (MR) measurements of brainstem structures have been reported to be useful in differentiating patients with progressive supranuclear palsy (PSP) from those with Parkinson's disease (PD). The aim of this study was to determine whether quantitative measurements of brainstem structures on MR images can help differentiate vascular parkinsonism (VaP) from degenerative parkinsonism (PD and PSP). Areas of the midbrain and pons, and widths of the superior cerebellar peduncle (SCP) and middle cerebellar peduncle (MCP) were measured in 62 patients with PD, 25 patients with PSP (11 probable and 14 possible), and 24 patients with VaP on T 1-weighted MR images...
January 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28077646/adenovirus-modulates-toll-like-receptor-4-signaling-by-reprogramming-orp1l-vap-protein-contacts-for-cholesterol-transport-from-endosomes-to-the-endoplasmic-reticulum
#2
Nicholas L Cianciola, Stacey Chung, Danny Manor, Cathleen R Carlin
: Human adenoviruses generally cause mild self-limiting infections but can lead to serious disease and even be fatal in high-risk individuals, underscoring the importance of understanding how the virus counteracts host defense mechanisms. This study had two goals. First, determine the molecular basis of cholesterol homeostatic responses induced by the early region 3 membrane protein RIDα via its direct interaction with the sterol-binding protein ORP1L. Second, determine how this interaction regulates innate immunity to adenovirus...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28073994/vibrating-mesh-nebulizer-compared-with-metered-dose-inhaler-in-mechanically-ventilated-subjects
#3
Meagan N Dubosky, Yi-Fan Chen, Mary E Henriksen, David L Vines
BACKGROUND: The impact of various aerosol delivery devices on patient outcomes during mechanical ventilation is unknown. If one method of delivery results in a higher ventilator-associated pneumonia (VAP) rate than another, multiple patient outcomes may be affected. This study aimed to determine whether there was a difference in VAP occurrence and patient outcomes (days receiving ventilation and in-hospital mortality) between the vibrating mesh nebulizer (AeroNeb Solo) and the metered-dose inhaler (MDI)...
January 10, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28070786/training-parents-of-youth-with-autism-spectrum-disorder-to-advocate-for-adult-disability-services-results-from-a-pilot-randomized-controlled-trial
#4
Julie Lounds Taylor, Robert M Hodapp, Meghan M Burke, Sydney N Waitz-Kudla, Carol Rabideau
This study presents findings from a pilot randomized controlled trial, testing a 12-week intervention to train parents of youth with autism spectrum disorder (ASD) to advocate for adult disability services-the Volunteer Advocacy Program-Transition (VAP-T). Participants included 41 parents of youth with ASD within 2 years of high school exit, randomly assigned to a treatment (N = 20) or wait-list control (N = 21) group. Outcomes, collected before and after the intervention, included parental knowledge about adult services, advocacy skills-comfort, and empowerment...
January 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28069649/antimicrobial-activity-of-ceftazidime-avibactam-when-tested-against-gram-negative-bacteria-isolated-from-patients-hospitalized-with-pneumonia-in-united-states-medical-centers-2011-2015
#5
Helio S Sader, Mariana Castanheira, Robert K Flamm
Bacterial isolates were collected from patients hospitalized with pneumonia (PHP), including ventilator-associated (VAP), from 76 USA medical centers in 2011-2015. The Gram-negative organisms (n=11,185; including 1,097 from VAP) were tested for susceptibility against ceftazidime-avibactam and comparators by broth microdilution method. β-lactamase-encoding genes were screened using a microarray based assay on selected isolates. Pseudomonas aeruginosa and Klebsiella spp. were the most common Gram-negatives isolated from PHP and VAP...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28067677/the-microbiome-in-mechanically-ventilated-patients
#6
Yudong Yin, Peter Hountras, Richard G Wunderink
PURPOSE OF REVIEW: Discovery of a normal lung microbiome requires reassessment of our concepts of HAP/VAP pathogenesis and has important implications for clinical diagnosis and management. RECENT FINDINGS: Changes in the microbiome of dental plaque are associated with increased risk of HAP/VAP. A transition to a lung microbiome enriched with gut flora is found in ARDS with an increased inflammatory response in patients with this change in microbial flora. A characteristic microbiome pattern of higher amounts of bacterial DNA, lower community diversity, and greater relative abundance of a single species characterize pneumonia and occasionally identify bacteria not found in culture...
January 6, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28063626/effect-of-chamber-characteristics-loading-and-analysis-time-on-motility-and-kinetic-variables-analysed-with-the-casa-mot-system-in-goat-sperm
#7
R Del Gallego, S Sadeghi, E Blasco, C Soler, J L Yániz, M A Silvestre
Several factors unrelated to the semen samples could be influencing in the sperm motility analysis. The aim of the present research was to study the effect of four chambers with different characteristics, namely; slide-coverslip, Spermtrack, ISAS D4C10, and ISAS D4C20 on the sperm motility. The filling procedure (drop or capillarity) and analysis time (0, 120 and 240s), depth of chamber (10 or 20μm) and field on motility variables were analysed by use of the CASA-mot system in goat sperm. Use of the drop-filling chambers resulted in greater values than capillarity-filling chambers for all sperm motility and kinetic variables, except for LIN (64...
December 26, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/28060857/pseudomonas-aeruginosa-ventilator-associated-pneumonia-induces-lung-injury-through-tnf-%C3%AE-c-jun-nh2-terminal-kinase-pathways
#8
Ying-Wei Yang, Yu-Zhen Jiang, Ching-Mei Hsu, Lee-Wei Chen
Ventilator-associated pneumonia (VAP) is a common nosocomial infection among intensive care unit (ICU) patients. Pseudomonas aeruginosa (PA) is the most common multidrug-resistant Gram-negative pathogen and VAP caused by PA carries a high rate of morbidity and mortality. This study examined the molecular mechanism of PA VAP-induced lung injury. C57BL/6 wild-type (WT) mice and JNK1 knockout (JNK1-/-) mice received mechanical ventilation (MV) for 3 h at 2 days after receiving nasal instillation of PA. The WT and JNK1-/- mice also received MV after the induction of lung injury by instillation of supernatants from PA-stimulated alveolar macrophages (AMs)...
2017: PloS One
https://www.readbyqxmd.com/read/28051826/-vap-and-oral-hygiene-a-systematic-review
#9
F Guerra, F De Martino, M Capocci, F Rinaldo, A Mannocci, A De Biase, L Ottolenghi, G La Torre
Ventilator associated pneumonia (VAP) is a common nosocomial infection in intensive care units. International literature showed how the use of professional oral hygiene protocols provide an essential support in VAP prevention. The aim of this study is to provide a systematic and narrative updated review, to further demonstrate that a proper protocol of oral hygiene, in special needs patients, can reduce risk of developing VAP. In this study were analyzed 10 narrative and 3 systematic reviews. Systematic reviews were evaluated with AMSTAR checklist, INSA tool was used to analyze narrative reviews...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28049457/breathdx-molecular-analysis-of-exhaled-breath-as-a-diagnostic-test-for-ventilator-associated-pneumonia-protocol-for-a-european-multicentre-observational-study
#10
Pouline M P van Oort, Tamara Nijsen, Hans Weda, Hugo Knobel, Paul Dark, Timothy Felton, Nicholas J W Rattray, Oluwasola Lawal, Waqar Ahmed, Craig Portsmouth, Peter J Sterk, Marcus J Schultz, Tetyana Zakharkina, Antonio Artigas, Pedro Povoa, Ignacio Martin-Loeches, Stephen J Fowler, Lieuwe D J Bos
BACKGROUND: The diagnosis of ventilator-associated pneumonia (VAP) remains time-consuming and costly, the clinical tools lack specificity and a bedside test to exclude infection in suspected patients is unavailable. Breath contains hundreds to thousands of volatile organic compounds (VOCs) that result from host and microbial metabolism as well as the environment. The present study aims to use breath VOC analysis to develop a model that can discriminate between patients who have positive cultures and who have negative cultures with a high sensitivity...
January 3, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28044236/vascular-adhesion-protein-1-in-hemodialysis-and-hemodiafiltration-patients-effect-of-single-hemodialysis-session-on-its-level-in-regard-to-type-of-anticoagulant
#11
Jolanta Malyszko, Ewa Koc-Zorawska, Piotr Kozminski, Jacek S Malyszko
PURPOSE: Traditional anticoagulants used in intermittent hemodialysis (HD) are unfractionated heparin (UFH) and increasingly low molecular weight heparins (LMWHs). Repeated and prolonged exposure to UFH and/or LMWHs may further disturb hemostasis in uremic patients. Vascular adhesion protein-1 (VAP-1) is secreted by vascular smooth muscle cells, adipocytes and endothelial cells with functional monoamine oxidase activity and is elevated in atherosclerosis, diabetes mellitus and obesity...
January 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28043748/subpectoral-biceps-tenodesis-for-tenosynovitis-of-the-long-head-of-the-biceps-in-active-patients-younger-than-45%C3%A2-years-old
#12
Dimitri S Tahal, J Christoph Katthagen, Alexander R Vap, Marilee P Horan, Peter J Millett
PURPOSE: The objective of this study was to assess the outcomes after subpectoral biceps tenodesis (BT) for long head of the biceps (LHB) tenosynovitis in active patients <45 years old. METHODS: This was an Institutional Review Board-approved, retrospective outcomes study with prospectively collected data. Patients treated with subpectoral BT were included if they met the following criteria: age <45 years, anterior shoulder pain with arthroscopically confirmed LHB tenosynovitis, no concomitant procedures other than debridement and decompression procedures, and minimum 2 years out from surgery...
December 30, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28034888/ultra-short-course-antibiotics-for-patients-with-suspected-ventilator-associated-pneumonia-but-minimal-and-stable-ventilator-settings
#13
Michael Klompas, Lingling Li, John T Menchaca, Susan Gruber
PURPOSE: Many patients started on antibiotics for possible ventilator-associated pneumonia (VAP) do not have pneumonia. Patients with minimal and stable ventilator settings may be suitable candidates for early antibiotic discontinuation. We compared outcomes amongst patients with suspected VAP but minimal and stable ventilator settings treated with 1-3 versus >3 days of antibiotics. METHODS: We identified consecutive adult patients started on antibiotics for possible VAP with daily minimum PEEPs ≤5cm H2O and FiO2s ≤40% for at least 3 days within a large tertiary care hospital between 2006-2014...
December 29, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28012719/cysteamine-supplementation-revealed-detrimental-effect-on-cryosurvival-of-buffalo-sperm-based-on-computer-assisted-semen-analysis-and-oxidative-parameters
#14
Dheer Singh Swami, Pradeep Kumar, R K Malik, Monika Saini, Dharmendra Kumar, M H Jan
The aim of this study was to investigate the effect of addition of cysteamine to the semen extender on post-thaw semen quality. A total of 30 ejaculates were collected from six bulls. Each ejaculate was divided into five equal parts and diluted to final concentration of 80 million sperms/mL using Optixcell(®)(IMV, France) semen extender supplemented with different concentrations of cysteamine (0, 0.75, 1.25, 2.5 and 5mM) and cryopreserved. In the frozen-thawed samples, the VAP, VSL, VCL ALH and sperm motility of control samples was greater (P<0...
December 13, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27992528/colistin-dosage-without-loading-dose-is-efficacious-when-treating-carbapenem-resistant-acinetobacter-baumannii-ventilator-associated-pneumonia-caused-by-strains-with-high-susceptibility-to-colistin
#15
Rocío Álvarez-Marín, Rafael López-Rojas, Juan Antonio Márquez, María José Gómez, José Molina, José Miguel Cisneros, Carlos Ortiz-Leyba, Javier Aznar, José Garnacho-Montero, Jerónimo Pachón
OBJECTIVES: This study aims to analyze the mortality and the length of ICU stay (LOS) of A. baumannii VAP compared to respiratory colonization in patients with mechanical ventilation (MV). METHODS: A prospective cohort study was performed in an ICU of adult patients (February 2010-June 2011). One hundred patients on MV with A. baumannii in lower respiratory airways were recruited, and classified as VAP or airways colonization according to CPIS criteria, with a punctuation ≥6...
2016: PloS One
https://www.readbyqxmd.com/read/27992521/evaluation-of-the-xpert-carba-r-cepheid-assay-using-contrived-bronchial-specimens-from-patients-with-suspicion-of-ventilator-associated-pneumonia-for-the-detection-of-prevalent-carbapenemases
#16
Almudena Burillo, Mercedes Marín, Emilia Cercenado, Guillermo Ruiz-Carrascoso, María Jesús Pérez-Granda, Jesús Oteo, Emilio Bouza
There is a critical need for rapid diagnostic methods for multidrug-resistant (MDR) pathogens in patients with a suspicion of ventilator-associated pneumonia (VAP). The Xpert Carba-R detects 5 targets for carbapenemase-producing organisms (blaKPC, blaNDM, blaVIM, blaOXA-48, and blaIMP-1). Our objective was to evaluate the performance of this assay directly on bronchial aspirates and to correlate the cycle number for a positive result (Ct) with the bacterial count. Bronchial aspirates from patients with a suspicion of VAP were spiked with a dilution of 1 of 4 MDR organisms carrying the resistance genes detected by the test prepared to a final concentration of 102-105 cfu/mL...
2016: PloS One
https://www.readbyqxmd.com/read/27991885/origins-of-pandemic-vibrio-cholerae-from-environmental-gene-pools
#17
B Jesse Shapiro, Inès Levade, Gabriela Kovacikova, Ronald K Taylor, Salvador Almagro-Moreno
Some microorganisms can transition from an environmental lifestyle to a pathogenic one(1-3). This ecological switch typically occurs through the acquisition of horizontally acquired virulence genes(4,5). However, the genomic features that must be present in a population before the acquisition of virulence genes and emergence of pathogenic clones remain unknown. We hypothesized that virulence adaptive polymorphisms (VAPs) circulate in environmental populations and are required for this transition. We developed a comparative genomic framework for identifying VAPs, using Vibrio cholerae as a model...
December 19, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27974112/-effect-of-early-caffeine-treatment-on-the-need-for-respirator-therapy-in-preterm-infants-with-respiratory-distress-syndrome
#18
Qiao-Zhen Wei, Ping Su, Jin-Tian Han, Xia Zhang, Yu-Hui Duan
OBJECTIVE: To study the efficacy of early caffeine treatment in preterm infants with respiratory distress syndrome (RDS). METHODS: A prospective controlled clinical trial was performed. A total of 59 preterm infants with RDS were enrolled and divided into a caffeine group (30 infants) and a control group (29 infants). Caffeine was administered in the caffeine group and control group at the same dosage at 12-24 hours after birth and before extubation respectively...
December 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27942786/-ventilator-associated-pneumonia-vap-a%C3%A2-risk-already-at-the-time-of-anesthetic-induction
#19
L Vetter, C Konrad, G Schüpfer, M Rossi
BACKGROUND: Ventilator-associated pneumonia (VAP) is one of the most common and preventable infections in mechanically ventilated patients. It is associated with a high mortality rate. To prevent VAP, various strategies address this issue using "VAP-bundles", which are implemented in many intensive care units. The risk of acquiring VAP starts with the induction of anesthesia, strictly speaking at the time of intubation. This article considers measures to prevent VAP during general anesthesia in adult patients (>18 years)...
December 9, 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27941626/the-protective-effect-of-selenium-on-chronic-zearalenone-induced-reproductive-system-damage-in-male-mice
#20
Miao Long, Shuhua Yang, Yuan Wang, Peng Li, Yi Zhang, Shuang Dong, Xinliang Chen, Jiayi Guo, Jianbin He, Zenggui Gao, Jun Wang
This study aims to explore the protective effect of selenium (Se) on chronic zearalenone (ZEN)-induced reproductive system damage in male mice and the possible protective molecular mechanism against this. The chronic ZEN-induced injury mouse model was established with the continuous intragastric administration of 40 mg/kg body mass (B.M.) ZEN for 28 days. Then, interventions with different doses (0.1, 0.2, and 0.4 mg/kg B.M.) of Se were conducted on mice to analyse the changes in organ indexes of epididymis and testis, antioxidant capability of testis, serum level of testosterone, sperm concentration and motility parameters, and the expression levels of apoptosis-associated genes and blood testis barrier- (BTB) related genes...
December 7, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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