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Fine needle aspiration cytology

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https://www.readbyqxmd.com/read/29676378/extranodal-histiocytic-sarcoma-in-a-child-with-acute-lymphoblastic-leukemia-cytomorphological-features-of-a-rare-entity-with-brief-review-of-literature
#1
Krushna Chandra Pani, Mahima Yadav, Shaleen Kumar, Vinita Agrawal
Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphologic and immunophenotypic evidence of histiocytic differentiation. We describe a rare case of synchronous HS in a patient of B-cell acute lymphoblastic leukemia (ALL). A 16-year-old boy diagnosed as ALL also presented with a swelling over the right Achilles tendon. The cytological features of the swelling suggested a histiocytic lesion. Histological and immunohistochemical examination clinched the diagnosis of HS. The available 5-year follow-up showed no recurrence...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29673124/liquid-based-cytology-in-the-diagnosis-of-langerhans-cell-sarcoma-a-case-report
#2
Kazumi Iwasaki, Yasuhiro Sakai, Masaki Mori, Yoshiaki Imamura
Langerhans cell sarcoma (LCS) is an extremely rare malignant dendritic cell neoplasm with Langerhans cell differentiation. Conventional cytology, based on cell morphology alone, cannot render a cytological diagnosis of LCS because immunochemical analysis is essential to identify the Langerhans cell immunophenotype. We present a case illustrating the value of liquid-based cytology with immunocytochemistry as compared with conventional cytology, along with histological and immunohistochemical findings. A 92-year-old woman presented with a 1-month history of progressive right cervical lymphadenopathy...
April 19, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29673102/cytodiagnosis-of-inflammatory-myofibroblastic-tumor-a-report-of-three-cases-in-infants
#3
Moupali Ghosh, Nelofar Islam, Hinglaj Saha, Madhumita Mukhopadhyay, Chhanda Datta, Koushik Saha, Uttara Chatterjee
Inflammatory myofibroblastic tumor is a tumor of intermediate grade with a low rate of metastasis. The tumor often mimics malignancy. There is sparse literature available describing the cytological findings of this rare condition. It often presents in infancy and childhood as an intra-abdominal mass. Here, we describe the cytological findings of three cases of inflammatory myofibroblastic tumor in infants aged 10 months, 4 months, and 15 months, respectively. While the first two cases are fine needle aspiration cytology (FNAC) smears, the third case is that of an intraoperative imprint cytology...
April 19, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29669480/tert-hras-and-eif1ax-mutations-in-a-patient-with-follicular-adenoma
#4
Michael C Topf, Zi-Xuan Wang, Madalina Tuluc, Edmund A Pribitkin
BACKGROUND: Molecular markers are increasingly used as diagnostic tools in the management of thyroid nodules. There is a paucity of studies evaluating the prevalence of molecular markers in benign lesions. PATIENT FINDINGS: A 68-year-old woman with hypothyroidism presented with a right thyroid nodule which was atypia of undetermined significance on cytology. The fine needle aspirate of the nodule was examined with next-generation sequencing and found to harbor a C228T mutation in the TERT gene, a Q61R mutation in the HRAS gene, and an A113_splice mutation in the EIF1AX gene...
April 19, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29668629/asymptomatic-intrathyroidal-pyriform-sinus-fistula-mimicking-thyroid-cancer-a-case-report-and-literature-review
#5
Soo Chin Kim, Ji-Hoon Kim, Jae-Kyung Won, Eun Jae Chung
RATIONALE: There have been many reports of non-thyroidal lesions which can be mistaken for thyroidal lesions on ultrasound (US) examination. However, it is not known that pyriform sinus fistula (PSF) can manifest as an incidental thyroid nodule and cause serious complication on fine-needle aspiration (FNA). PATIENT CONCERNS: We present a 34-year-old man with PSF incidentally detected on US. US examination showed hypoechoic nodule with several bright echogenic spots at the uppermost part of left thyroid gland...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667282/cardiac-gated-phase-contrast-magnetic-resonance-angiography-is-a-reliable-and-reproducible-technique-for-quantifying-blood-flow-in-canine-major-cranial-abdominal-vessels
#6
Francesca Del Chicca, Andrea Schwarz, Paula Grest, Florian Willmitzer, Matthias Dennler, Patrick R Kircher
Blood flow changes in cranial abdominal vessels are important contributing factors for canine hepatic disease. This prospective, experimental, pilot study aimed to evaluate cardiac-gated, phase contrast magnetic resonance angiography (PCMRA) as a method for characterizing blood flow in canine major cranial abdominal vessels. Eleven, healthy, adult beagle dogs were sampled. Cardiac-gated, phase contrast magnetic resonance angiography of the cranial abdomen was performed in each dog and blood flow was independently measured in each of the major cranial abdominal vessels by three observers, with two observers recording blood flow values once and one observer recording blood flow values three times...
April 17, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29661735/fine-needle-aspiration-of-alveolar-soft-part-sarcoma-in-a-child-cytomorphological-clues-for-the-surgical-pathologist
#7
Mohamed Mostafa, Daniel Abbott, Lauren N Parsons
Alveolar soft part sarcoma (ASPS) is a rare soft tissue neoplasm generally affecting adolescents and young adults. Its unique histologic and ultrastructural features have been well-described; however, the cytopathological features of ASPS are less well-characterized, and recognition of this entity's features on cytologic preparations can ensure that the specimen adequacy and appropriate/rapid tissue allocation for additional testing. Herein we report a FNA case of ASPS with emphasis on cytomorphologic characteristics...
February 23, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661546/strategy-for-the-accurate-preoperative-evaluation-of-the-number-of-metastatic-axillary-lymph-nodes-in-breast-cancer
#8
Nao Imai, Mika Kitayama, Akiko Shibahara, Yuri Bessho, Mai Shibusawa, Aya Noro, Keiko Inakami, Noriko Hanamura, Hiroshi Imai, Tomoko Ogawa
BACKGROUND: After the ACOSOG Z0011 trial, it became important to evaluate the number of metastatic axillary lymph nodes (LNs) preoperatively. The purpose of this paper is to confirm whether the number of metastases can be accurately diagnosed by preoperative computed tomography (CT), ultrasound sonography (US), and US-guided fine-needle aspiration cytology (FNAC). METHODS: We retrospectively analyzed the axillary LNs finding of preoperative CT/US of 470 breast cancer patients...
April 13, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29643676/discordant-primary-resistance-to-imatinib-mesylate-in-the-same-individual-and-splenic-involvement-in-recurring-gastric-gastrointestinal-stromal-tumors-assessment-by-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#9
Preeti Fargose, Sandip Basu
Discordant primary resistance and response of the metastatic lesions in the same individual coupled with splenic involvement in gastrointestinal stromal tumors (GISTs) are relatively uncommon. We herein report such a case of recurring GIST of the stomach that presented with the involvement of spleen with 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) imaging documentation. Ultrasonography-guided fine needle aspiration cytology from the splenic and paravesical lesions demonstrated metastatic spindle cell tumor consistent with diagnosis of metastasis from GIST of the stomach...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29643662/retinoblastoma-in-an-adult
#10
Vasudha Garg, Ashumi Gupta, Sonam K Pruthi, Pratima Khare
Retinoblastoma is a rare malignant tumor of the retina usually seen in children before 5 years of age. The tumor is extremely rare in adults. We report here an unusual case of retinoblastoma in a 55-year-old adult female who presented to us with an orbital mass at a late stage of the disease. Detailed laboratory investigations and imaging studies could not make a precise diagnosis. The treating ophthalmologist suspected primary intraocular tumor, metastatic carcinoma, malignant melanoma, or lymphoma and referred the patient for fine needle aspiration cytology (FNAC)...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643660/primary-splenic-angiosarcoma-with-liver-metastasis-a-rare-neoplasm-diagnosed-on-fine-needle-aspiration-cytology-and-cell-block-immunocytochemistry
#11
Saniya Sharma, Priya Singh, Pankaj Gupta, Anupam Lal, Radhika Srinivasan
Primary splenic angiosarcoma is a rare malignant vascular neoplasm of mesenchymal origin. The tumor is highly aggressive and has a high metastatic potential. It is usually diagnosed on histopathological examination of splenectomy specimen. Only few cases of angiosarcoma diagnosed by fine-needle aspiration (FNA) cytology alone have been reported in the literature. The cytologic features of angiosarcoma are heterogeneous, however, diagnosis can be suggested by FNA when vasoformative features are present. A 55-year-old female presented with abdominal pain and hepatosplenomegaly...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643657/analysis-of-morphological-features-of-benign-and-malignant-breast-cell-extracted-from-fnac-microscopic-image-using-the-pearsonian-system-of-curves
#12
Nijara Rajbongshi, Kangkana Bora, Dilip C Nath, Anup K Das, Lipi B Mahanta
Context: Cytological changes in terms of shape and size of nuclei are some of the common morphometric features to study breast cancer, which can be observed by careful screening of fine needle aspiration cytology (FNAC) images. Aims: This study attempts to categorize a collection of FNAC microscopic images into benign and malignant classes based on family of probability distribution using some morphometric features of cell nuclei. Materials and Methods: For this study, features namely area, perimeter, eccentricity, compactness, and circularity of cell nuclei were extracted from FNAC images of both benign and malignant samples using an image processing technique...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643655/gata3-immunohistochemical-staining-is-a-useful-marker-for-metastatic-breast-carcinoma-in-fine-needle-aspiration-specimens
#13
Paul W Shield, Stephen J Crouch, David J Papadimos, Michael D Walsh
Aims: The utility of GATA3 immunohistochemistry (IHC) as an aid to the cytological diagnosis of metastatic breast carcinoma in fine needle aspiration (FNA) specimens was investigated. Materials and Methods: Cell block sections from 111 FNA cases of metastatic malignancy were stained for GATA3, including metastases from 43 breast and 44 nonmammary adenocarcinomas, 19 melanomas, 4 urothelial carcinomas, and 1 thyroid medullary carcinoma. Sites sampled included lymph nodes (87), bone (8), liver (5), lung (6), superficial masses (4), and pelvic mass (1)...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643654/role-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-adrenal-lesions-analysis-of-32-patients
#14
Rakesh K Gupta, Kaushik Majumdar, Ravindra K Saran, Siddharth Srivastava, Puja Sakhuja, Vineeta V Batra
Objective: Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) is a precise and safe technique that provides both radiological and pathological diagnosis with a better diagnostic yield and minimal adverse events. EUS-FNAC led to the remarkable increase in the detection rate of incidentaloma found during radiologic staging or follow-up in various malignancy or unrelated conditions. Aims: We did this preliminary study with an aim to evaluate the role of EUS-FNA in diagnosing and classifying adrenal lesions, clinical impact, and compare the outcome with the previously published literature...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643652/utility-of-cytokeratin7-immunocytochemistry-in-the-cytopathological-diagnosis-of-fibrolamellar-hepatocellular-carcinoma
#15
Rashi Garg, Radhika Srinivasan, Pranab Dey, Priya Singh, Nalini Gupta, Arvind Rajwanshi
Objective: To distinguish fibrolamellar hepatocellular carcinoma (FL-HCC) variant from the conventional hepatocellular carcinoma (HCC) by cytology, immunocytochemistry, and morphometry. Study Design: Retrospective detailed cytomorphological, immunocytochemical, and morphometric analysis was performed in 6 cases of FL-HCC reported on fine needle aspiration. Cell block immunocytochemistry (CB-ICC) for CK7 and CD68 was performed in four cases. Morphometry was carried out with Cell A software...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29630086/isolated-epitrochlear-filarial-lymphadenopathy-cytomorphological-diagnosis-of-an-unusual-presentation
#16
Priya Sahu, Prajwala Gupta, Minakshi Bhardwaj, C K Durga
Filariasis is a major public health problem in tropical countries like India. Despite the large number of people at risk, detection of eggs with or without larva (microfilaria) on fine-needle aspiration cytology is very unusual, especially in an uncommon site or incidentally detected in clinically unsuspected cases of filariasis with the absence of microfilariae in the peripheral blood. A 19-year-old male presented with swelling over medial aspect of left arm (just above the elbow), with no other specific signs and symptoms...
April 9, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29628731/myofibroblastoma-of-the-breast-a-rare-cause-of-breast-lump-in-a-postmenopausal-woman
#17
Yasmeen Khatib, Vinita Pandey, Archana L Khade, Rahul Pandey
A breast mass in a postmenopausal age woman is treated with a high index of clinical suspicion for malignancy. Myofibroblastoma (MFB) of the breast is a very rare benign stromal tumor, predominantly occurring in menopausal women and older men. Owing to its rarity, nonspecific radiology, cytomorphology, and many variants, it can be confused with other malignant and benign breast lesions and hence can be a source of diagnostic pitfall. We present a case of an MFB of the breast in a 55-year-old female, which was detected on a routine screening mammography...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29628728/breast-abscess-mimicking-breast-carcinoma-in-male
#18
Debasis Gochhait, Priyadarshini Dehuri, Sandyya Umamahesweran, Rohan Kamat
Male breast can show almost all pathological entities described in female breast. Inflammatory conditions of the breast in male are not common; however, occasionally, it can be encountered in the form of an abscess. Clinically, gynecomastia always presents as a symmetric unilateral or bilateral lump in the retroareolar region, and any irregular asymmetric lump raises a possibility of malignancy. Radiology should be used as a part of the triple assessment protocol for breast lump along with fine-needle aspiration cytology for definite diagnosis and proper management...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29626008/differences-between-ata-aace-ace-ame-and-acr-ti-rads-ultrasound-classifications-performance-in-identifying-cytological-high-risk-thyroid-nodules
#19
Angelo Lauria, Ernesto Maddaloni, Silvia Irina Briganti, Giuseppina Beretta Anguissola, Eleonora Perrella, Chiara Taffon, Andrea Palermo, Paolo Pozzilli, Silvia Manfrini, Anna Crescenzi
OBJECTIVE: Thyroid ultrasound is crucial for clinical decision in the management of thyroid nodules. In this study we aimed to estimate and compare the performance of ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications in discriminating nodules with high-risk cytology. DESIGN: Cross sectional study Methods 1077 thyroid nodules undergoing fine needle aspiration were classified according to ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications by an automated algorithm...
April 6, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29624918/fine-needle-aspiration-of-tubulocystic-renal-cell-carcinoma
#20
Andrew A Renshaw, Edwin W Gould
We report two cases of tubulocystic renal cell carcinoma, a rare renal tumor the cytology of which has not been previously reported. Both aspirates were cellular and contained large sheets of cells with abundant granular cytoplasm, distinct cell borders and intracellular windows, distinct to prominent nucleoli, rare intracytoplasmic vacuoles, and rare nuclear grooves. Cells with variable amounts of cytoplasm were also arranged in small groups, some of which resembled spherules. The large sheets of cells with windows appeared specific for tubulocystic carcinoma; the spherules could easily be confused with a papillary renal cell carcinoma...
April 6, 2018: Diagnostic Cytopathology
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