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Fine needle aspiration cytology

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https://www.readbyqxmd.com/read/29451738/well-differentiated-grade-3-pancreatic-neuroendocrine-tumors-compared-with-related-neoplasms-a-morphologic-study
#1
Carlie S Sigel, Vitor Werneck Krauss Silva, Michelle D Reid, David Chhieng, Olca Basturk, Keith M Sigel, Tanisha D Daniel, David S Klimstra, Laura H Tang
BACKGROUND: Pancreatic neuroendocrine neoplasms with a Ki-67 labeling index greater than 20% were reclassified in 2017 by the World Health Organization into well differentiated (WD) and poorly differentiated grade 3 neuroendocrine carcinoma (NEC). The authors describe the cytologic features of grade 3 WD pancreatic neuroendocrine neoplasms compared with grade 2 neoplasms and NEC. METHODS: Fine-needle aspirates from 65 pancreatic neuroendocrine neoplasms were reviewed, and their cytomorphologic features were compared across grade 2, WD grade 3, and PD small cell type (PD-S), large cell type (PD-L), and type not otherwise specified (PD-NOS) neoplasms...
February 16, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29449722/current-usefulness-of-aspiration-cytology-fnac-in-the-head-and-neck-diagnosis
#2
S Dallari, P M Gusella, P Campanella, M Ciommi, P Pantanetti, E Tortato, A Castriotta
Background: Fine Needle Aspiration Cytology (FNAC) is a well established and widely used method for both a preliminary and sometime final non-invasive pathologic diagnosis. FNAC is a simple and inexpensive diagnostic tool and should represent the standard of care in developing and resource-poor countries while maintaining its diagnostic usefulness in developed and advanced ones. Methods: The concordance between preoperative FNAC and final histology was evaluated in 168 patients operated on at the Otorhinolaryngology Unit, "A...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29446257/utilization-of-direct-smears-of-thyroid-fine-needle-aspirates-for-ancillary-molecular-testing-a-comparison-of-two-proprietary-testing-platforms
#3
Kristen L Partyka, Melissa L Randolph, Karen A Lawrence, Harvey Cramer, Howard H Wu
BACKGROUND: Ancillary molecular testing has been recommended for thyroid fine-needle aspirates (FNA) with indeterminate cytologic diagnoses. Rosetta Genomics and Interpace Diagnostics have developed assays that can utilize direct smears as the testing substrate. METHODS: A retrospective study of indeterminate thyroid FNAs with known histologic follow-up was performed. One Diff-Quik-stained smear and one Papanicolaou-stained smear with similar cellularity (at least 60-100 lesional cells) from each case were sent to Rosetta and Interpace, respectively, for analysis...
February 15, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29445071/a-case-report-of-thyroid-metastasis-from-p16-positive-oropharyngeal-squamous-cell-carcinoma
#4
Masao Takenobu, Sueyoshi Moritani, Kana Yoshioka, Tsuyoshi Morisaki, Hiroya Kitano
Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy...
February 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29443775/primary-undifferentiated-pleomorphic-sarcoma-of-the-thyroid-a-case-report-and-review-of-the-literature
#5
REVIEW
Qiang Chen, Qing Huang, Jia-Xin Yan, Chao Li, Jin-Yi Lang
RATIONALE: Primary undifferentiated pleomorphic sarcoma is extremely rare in the thyroid, and can be easily misdiagnosed as anaplastic thyroid cancer. PATIENT CONCERNS: We present a case of a 71-year-old woman who presented with a rapidly growing painless mass in the neck. DIAGNOSES-INTERVENTIONS-OUTCOMES: Computed tomography showed a large hypointense mass with hyperdense areas involving whole of the right lobe of thyroid gland and fine-needle aspiration cytology found a few atypical cells...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443748/ultrasound-combined-with-fine-needle-aspiration-cytology-for-the-assessment-of-axillary-lymph-nodes-in-patients-with-early-stage-breast-cancer
#6
Fan Zhang, Jing Zhang, Qing-Xin Meng, Xin Zhang
This study aimed to explore the clinical usefulness of ultrasound-guided fine needle aspiration cytology (USG-FNAC) for the evaluation of axillary lymph nodes in patients with early stage breast cancer (BC) among the Chinese Han female population.Around 124 patients with early stage BC were included in this retrospective study. All patients underwent USG-FNAC (group A). Patients with proven metastasis also underwent axillary lymph node dissection (ALND) (group B). In addition, sentinel lymph node biopsy (SLNB) was performed 2 to 5 hours prior to the surgery...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442093/a-review-of-research-on-cytological-approach-in-salivary-gland-masses
#7
Arvind Babu Rajendra Santosh, Shobha Rani Bakki, Suvarna Manthapuri
To evaluate the diagnostic accuracy of fine-needle aspirations (FNAs) in salivary gland pathologies. A comprehensive literature search was conducted in the PubMed database using related Medical Subject Heading terms "sensitivity and specificity of FNA in salivary gland" and "diagnostic accuracy of FNA in salivary gland" for the period 1980-2016, and we found that 414 research studies had been published. PRISMA technology was utilized to prepare flow chart for displaying data search strategy...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29439461/early-diagnosis-to-improve-the-poor-prognosis-of-pancreatic-cancer
#8
REVIEW
Masataka Kikuyama, Terumi Kamisawa, Sawako Kuruma, Kazuro Chiba, Shinya Kawaguchi, Shuzo Terada, Tatsunori Satoh
Pancreatic cancer (PC) has a poor prognosis due to delayed diagnosis. Early diagnosis is the most important factor for improving prognosis. For early diagnosis of PC, patients with clinical manifestations suggestive of PC and high risk for developing PC need to be selected for examinations for PC. Signs suggestive of PC (e.g., symptoms, diabetes mellitus, acute pancreatitis, or abnormal results of blood examinations) should not be missed, and the details of risks for PC (e.g., familial history of PC, intraductal mucin producing neoplasm, chronic pancreatitis, hereditary pancreatitis, or life habit) should be understood...
February 11, 2018: Cancers
https://www.readbyqxmd.com/read/29436307/cancers-of-the-major-salivary-gland
#9
Eugene Son, Aru Panwar, Charles H Mosher, Daniel Lydiatt
Salivary gland malignancies are rare tumors that comprise multiple histologic entities with diverse clinical behavior. Mucoepidermoid carcinoma is the most frequent primary salivary malignancy, followed by adenoid cystic and acinic cell carcinoma. Although most salivary malignancies are asymptomatic, presentation with a rapidly enlarging mass may be accompanied by pain, functional neurologic deficits, soft-tissue invasion, or nodal enlargement. Assessment of clinical behavior and physical exam greatly contributes to diagnostic workup...
February 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29429327/preoperative-cytologic-diagnosis-of-warthin-like-tumor-variant-of-papillary-thyroid-carcinoma
#10
Jisup Kim, Beom Jin Lim, Soon Won Hong, Ju Yeon Pyo
Background: Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution...
February 12, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29428095/effects-of-pre-analytical-variables-on-flow-cytometric-diagnosis-of-canine-lymphoma-a-retrospective-study-2009-2015
#11
S Comazzi, M Cozzi, S Bernardi, D R Zanella, L Aresu, D Stefanello, L Marconato, V Martini
Flow cytometry (FC) is increasingly being used for immunophenotyping and staging of canine lymphoma. The aim of this retrospective study was to assess pre-analytical variables that might influence the diagnostic utility of FC of lymph node (LN) fine needle aspirate (FNA) specimens from dogs with lymphoproliferative diseases. The study included 987 cases with LN FNA specimens sent for immunophenotyping that were submitted to a diagnostic laboratory in Italy from 2009 to 2015. Cases were grouped into 'diagnostic' and 'non-diagnostic'...
February 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29424960/the-impact-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-on-the-rate-of-malignancy-for-atypia-of-undetermined-significance-subcategories
#12
Jen-Fan Hang, William H Westra, Amy G Zhou, David S Cooper, Syed Z Ali
BACKGROUND: The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate the impact of this change on the rate of malignancy (ROM) for subcategories of an atypia of undetermined significance (AUS) diagnosis on fine-needle aspiration (FNA) cytology...
February 9, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29424371/incidental-thyroid-carcinoma-in-patients-with-tir1-tir2-and-tir3-fna
#13
Angela Pezzolla, Serafina Lattarulo, Graziana Barile, Daniele Paradies, Giuseppe Pentassuglia, Francesco Prete, Rinaldo Marzaioli
AIM: The aim of our study was to evaluate the presence of incidental differentiated thyroid carcinomas, at final histological examination, in patients undergoing thyroidectomy or lobectomy for presumed benign pathology or in those with cytological diagnosis of indeterminate nodules (TIR3). MATERIAL OF STUDY: 457 patients who underwent surgery for benign disease and 179 patients with indeterminate FNA were included in our study. RESULTS: 77 out of 457 patients had the diagnosis of differentiated thyroid carcinoma...
February 9, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29424100/-ease-of-interpretation-of-cytological-smears-stained-with-modified-ultrafast-papanicolaou-stain-interobserver-agreement-and-reproducibility
#14
Preithy Uthamalingam, Thabasum Sathish Kumar, Albina Venus, Preethi Sekar, Rajeshwari K Muthusamy, Sangita Mehta
BACKGROUND: Since its inception in 1995, the Ultrafast Papanicoloau (UFPAP) cytological stain has undergone a number of modifications to suit the local availability of reagents and cost in different set ups. However, the reported results have been uniformly encouraging. We designed a study to investigate the inter-observer agreement in 'perceived ease of interpretation' of cytological smears stained with Modified Ultrafast Papanicoloau stain (MUFPAP). METHODS: After a small pilot study, we prospectively stained air-dried fine needle aspirate smears (FNACs) and Body Fluid smears with the standardized MUFPAP stain...
February 9, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29420837/carcinosarcoma-mimicking-a-feline-injection-site-sarcoma-in-a-cat
#15
Rafał Sapierzyński
A 15-year-old spayed female domestic short-haired cat with cutaneous/subcutaneous well-circumscribed, alopecic mass approximately 25 × 30 mm in diameter, localized to the left shoulder region was brought to the veterinary surgery department. Despite the suggestive location and macroscopic appearance, feline injection-site sarcoma was not suspected based on the cytologic examination of fine-needle aspirates. The tumor was surgically resected, and tissue sections were evaluated microscopically. The tumor was found to be nonencapsulated with a distinct border between the neoplastic parenchyma and surrounding connective tissue...
February 8, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29420114/role-of-ct-chest-and-cytology-in-differentiating-tuberculosis-from-presumed-sarcoidosis-in-uveitis
#16
Reema Bansal, Amod Gupta, Ritesh Agarwal, Mohit Dogra, Garvit Bhutani, Vishali Gupta, M R Dogra, Deeksha Katoch, Ashutosh Nath Aggarwal, Aman Sharma, Raje Nijhawan, Ritambara Nada, Uma Nahar Saikia, Pranab Dey, Digambar Behera
PURPOSE: To report the role of CT chest and cytology in suspected tubercular and sarcoid uveitis. METHODS: This is a retrospective, interventional case series of 376 uveitis patients with suspected ocular tuberculosis (TB)/sarcoidosis seen between January 2010 and April 2015 at the Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. All underwent CT chest, and had following inclusion criteria: (1) Presence of active granulomatous anterior/intermediate/posterior uveitis or panuveitis; (2) a documented tuberculin skin test/QuantiFERON-TB Gold test; (3) all other causes of infectious/non-infectious uveitis ruled out...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29412881/cytopathology-in-low-medical-infrastructure-countries-why-and-how-to-integrate-to-capacitate-health-care
#17
REVIEW
Andrew S Field
Fine-needle aspiration cytology is a rapid, accurate, minimally invasive, inexpensive biopsy technique requiring minimal laboratory infrastructure and proceduralist costs. It provides infectious and noncommunicable disease diagnoses and will play an essential role in the establishment of cancer services in low-income and middle-income countries (LMICs). The use of molecular and other ancillary tests on cytology material is rapidly expanding in high-income countries and will spread to LMICs. Establishing cytology services requires increased training of cytopathologists and cytotechnologists, increased education of clinicians in the use of diagnostic cytopathology, and commitment and funding from governments and specialist training groups...
March 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29408952/predictive-value-of-malignancy-of-thyroid-nodule-ultrasound-classification-systems-a-prospective-study
#18
Agnese Persichetti, Enrico Di Stasio, Rinaldo Guglielmi, Giancarlo Bizzarri, Silvia Taccogna, Irene Misischi, Filomena Graziano, Lucilla Petrucci, Antonio Bianchini, Enrico Papini
Background: British Thyroid Association (BTA), American Thyroid Association (ATA) and American Association of Clinical Endocrinologists (AACE/ACE/AME) recommend for thyroid nodules an ultrasound (US)-based stratification of risk of malignancy. Aim of our study was to assess the diagnostic accuracy of US classification systems and their reliability for indication to fine-needle aspiration (FNA). Methods: Prospective study on 987 thyroid nodules consecutively referred for FNA...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29406562/synovial-cell-sarcoma-in-a-dog-a-misnomer-cytologic-and-histologic-findings-and-review-of-the-literature
#19
REVIEW
Paola Monti, Darren Barnes, Anna M Adrian, Roberta Rasotto
A 4-year-old Irish Setter was presented with a history of progressive left pelvic limb lameness. Orthopedic examination revealed pain on manipulation of the left stifle. Radiographs showed an osteolytic lesion in the subchondral bone of the medial tibial condyle. Fine-needle aspirates were taken, and cytology revealed numerous cohesive clusters of plump, oval to spindloid cells often with perivascular distribution and moderate cellular atypia. A diagnosis of sarcoma was made with synovial cell sarcoma (SCS) and histiocytic sarcoma being the 2 main differentials...
February 6, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29406334/hmga2-gene-expression-in-fine-needle-aspiration-samples-of-thyroid-nodules-as-a-marker-for-preoperative-diagnosis-of-thyroid-cancer
#20
Ivan Šamija, Neven Mateša, Sanja Kožaj, Ivana Majstorović, Ante Bolanča, Zvonko Kusić
There is a great interest in molecular markers that would help in the preoperative diagnosis of malignant thyroid nodules in cases of indeterminate fine-needle aspiration cytology. The aim of this study was to determine the diagnostic accuracy of HMGA2 gene expression in discriminating benign from malignant thyroid nodules. In this study, 237 preoperative thyroid fine-needle aspiration samples were analyzed prospectively for the expression of the HMGA2 gene by real-time reverse transcription polymerase chain reaction...
February 5, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
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